CBLE
MCID: CBL005
MIFTS: 19

Cble (CBLE) malady

Summaries for Cble

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32MalaCards
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MalaCards: Cble is related to homocystinuria and homocystinuria-megaloblastic anemia, cblg complementation type. An important gene associated with Cble is MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase), and among its related pathways are Metabolism of vitamins and cofactors and Metabolism of amino acids and derivatives. The compounds cob(ii)alamin and b vitamins have been mentioned in the context of this disorder.

Aliases & Classifications for Cble

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20GeneTests
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Aliases & Descriptions:

cble 20


Related Diseases for Cble

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Cble:



Diseases related to cble

Clinical Features for Cble

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Drugs & Therapeutics for Cble

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cble

Drug clinical trials:

Search ClinicalTrials for Cble

Search NIH Clinical Center for Cble

Search CenterWatch for Cble

Genetic Tests for Cble

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20GeneTests
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Genetic tests related to Cble:

id Genetic test Affiliating Genes
1 Cble20 MTRR

Anatomical Context for Cble

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Animal Models for Cble or affiliated genes

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Publications for Cble

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Genetic Variations for Cble

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Expression for genes affiliated with Cble

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cble

Search GEO for disease gene expression data for Cble.

Pathways for genes affiliated with Cble

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Cble

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Cble according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1cob(ii)alamin44 2410.4MTR, MTRR
2b vitamins449.4MTRR, MTR
3methylcobalamin44 2410.4MTRR, MTR
4hydroxocobalamin44 1110.4MTR, MTRR
5cyanocobalamin49 11 2411.4MTR, MTRR
65-methyltetrahydrofolate44 1110.3MTRR, MTR
7tetrahydrofolate449.3MTR, MTRR
8L-Methionine11 2410.3MTRR, MTR
9betaine44 2410.3MTRR, MTR
10cystathionine449.3MTR, MTRR
11methylmalonic acid44 2410.3MTR, MTRR
12cobalamin44 2410.3MTRR, MTR
13isoleucine449.3MTR, MTRR
14s-adenosylhomocysteine44 2410.2MTR, MTRR
15vitamin b12449.2MTRR, MTR
16thymidylate449.2MTR, MTRR
17homocysteine44 2410.1MTR, MTRR
18s-adenosylmethionine44 11 2411.1MTRR, MTR
19folate449.0MTR, MTRR
20methionine449.0MTR, MTRR
21methotrexate44 49 1110.9MTR, MTRR
22serine448.2MTRR, MTR, SRSF1

GO Terms for genes affiliated with Cble

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16Gene Ontology
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Biological processes related to Cble according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1methylationGO:0322599.2MTR, MTRR
2cobalamin metabolic processGO:0092359.1MTR, MTRR
3sulfur amino acid metabolic processGO:0000969.1MTR, MTRR
4water-soluble vitamin metabolic processGO:0067679.0MTRR, MTR
5cellular nitrogen compound metabolic processGO:0346419.0MTR, MTRR
6vitamin metabolic processGO:0067668.9MTR, MTRR
7xenobiotic metabolic processGO:0068058.7MTR, MTRR

Products for genes affiliated with Cble

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cble

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet