Aliases & Classifications for Cd40 Ligand Deficiency

MalaCards integrated aliases for Cd40 Ligand Deficiency:

Name: Cd40 Ligand Deficiency 12 14 69
X-Linked Hyper Igm Syndrome 12 23 24 14
Hyperimmunoglobulin M Syndrome 12 28 69
Hyper-Igm Syndrome 1 23 24
Higm1 23 24
Hyper-Igm Immunodeficiency Syndrome, Type 1 69
Immunodeficiency with Hyper-Igm, Type 1 24
X-Linked Hyper-Igm Immunodeficiency 23
Hyper-Igm Immunodeficiency Syndrome 41
X-Linked Hyper-Igm Syndrome 12
Higmx-1 12
Xhim 23

Characteristics:

GeneReviews:

23
Penetrance Penetrance is complete in males with a cd40lg pathogenic variant...

Classifications:



External Ids:

Disease Ontology 12 DOID:0060022 DOID:6620
MeSH 41 D053306
NCIt 46 C3990 C84783
SNOMED-CT 64 82286005

Summaries for Cd40 Ligand Deficiency

Genetics Home Reference : 24 X-linked hyper IgM syndrome is a condition that affects the immune system and occurs almost exclusively in males. People with this disorder have abnormal levels of proteins called antibodies or immunoglobulins. Antibodies help protect the body against infection by attaching to specific foreign particles and germs, marking them for destruction. There are several classes of antibodies, and each one has a different function in the immune system. Although the name of this condition implies that affected individuals always have high levels of immunoglobulin M (IgM), some people have normal levels of this antibody. People with X-linked hyper IgM syndrome have low levels of three other classes of antibodies: immunoglobulin G (IgG), immunoglobulin A (IgA), and immunoglobulin E (IgE). The lack of certain antibody classes makes it difficult for people with this disorder to fight off infections.

MalaCards based summary : Cd40 Ligand Deficiency, also known as x-linked hyper igm syndrome, is related to immunodeficiency with hyper-igm, type 1 and cryptosporidiosis, and has symptoms including diarrhea An important gene associated with Cd40 Ligand Deficiency is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Immune response NFAT in immune response and NF-kappaB Signaling. The drugs Antibodies and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and liver.

Disease Ontology : 12 A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE.

GeneReviews: NBK1402

Related Diseases for Cd40 Ligand Deficiency

Diseases related to Cd40 Ligand Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 immunodeficiency with hyper-igm, type 1 31.8 AICDA CD40 CD40LG CD79A
2 cryptosporidiosis 30.1 CD40LG CD79A
3 light fixation seizure syndrome 10.4 CD40 CD40LG
4 selective igg deficiency disease 10.4 CD40LG CD79A
5 c1q nephropathy 10.4 CD40LG CD79A
6 meningovascular neurosyphilis 10.4 CD40LG CD79A
7 alpha chain disease 10.4 CD40LG CD79A
8 brill-zinsser disease 10.4 CD40LG CD79A
9 exudative glomerulonephritis 10.4 CD40LG CD79A
10 cork-handlers' disease 10.4 CD40LG CD79A
11 salpingo-oophoritis 10.4 CD40LG CD79A
12 early yaws 10.4 CD40LG CD79A
13 ventilation pneumonitis 10.4 CD40LG CD79A
14 chronic interstitial cystitis 10.4 CD40LG CD79A
15 axillary adenitis 10.4 CD40LG CD79A
16 cryofibrinogenemia 10.4 CD40LG CD79A
17 trichostrongyloidiasis 10.4 CD40LG CD79A
18 subacute bacterial endocarditis 10.4 CD40LG CD79A
19 heterophyiasis 10.4 CD40LG CD79A
20 immunoglobulin g deficiency 10.4 CD40LG CD79A
21 orbital granuloma 10.4 CD40LG CD79A
22 transient hypogammaglobulinemia of infancy 10.4 CD40LG CD79A
23 hyperglobulinemic purpura 10.4 CD40LG CD79A
24 gastroduodenitis 10.4 CD40LG CD79A
25 bacterial conjunctivitis 10.4 CD40LG CD79A
26 heavy chain disease 10.4 CD40LG CD79A
27 ophthalmia neonatorum 10.4 CD40LG CD79A
28 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
29 parotid disease 10.4 CD40LG CD79A
30 cerebral arteritis 10.4 CD40LG CD79A
31 selective immunoglobulin deficiency disease 10.4 CD40LG CD79A
32 geniculate herpes zoster 10.4 CD40LG CD79A
33 erythema elevatum diutinum 10.4 CD40LG CD79A
34 sporotrichosis 10.4 CD40LG CD79A
35 fallopian tube disease 10.4 CD40LG CD79A
36 congenital syphilis 10.4 CD40LG CD79A
37 polyclonal hypergammaglobulinemia 10.4 CD40LG CD79A
38 monoclonal paraproteinemia 10.4 CD40LG CD79A
39 salpingitis 10.4 CD40LG CD79A
40 ocular toxoplasmosis 10.4 CD40LG CD79A
41 parasitic ichthyosporea infectious disease 10.4 CD40LG CD79A
42 dysgammaglobulinemia 10.4 CD40LG CD79A
43 congenital hypogammaglobulinemia 10.4 CD40LG CD79A
44 acute maxillary sinusitis 10.4 CD40LG CD79A
45 rhinosporidiosis 10.4 CD40LG CD79A
46 chronic polyneuropathy 10.4 CD40LG CD79A
47 spinocerebellar ataxia, autosomal recessive 10 10.4 CD40LG CD79A
48 secondary syphilis 10.4 CD40LG CD79A
49 yellow nail syndrome 10.4 CD40LG CD79A
50 congenital toxoplasmosis 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Cd40 Ligand Deficiency:



Diseases related to Cd40 Ligand Deficiency

Symptoms & Phenotypes for Cd40 Ligand Deficiency

UMLS symptoms related to Cd40 Ligand Deficiency:


diarrhea

Drugs & Therapeutics for Cd40 Ligand Deficiency

Drugs for Cd40 Ligand Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 4,Phase 3
2 gamma-Globulins Phase 4,Phase 3,Phase 2
3 Immunoglobulins Phase 4,Phase 3
4 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
5 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
6
Cyclophosphamide Approved, Investigational Phase 2,Not Applicable 50-18-0, 6055-19-2 2907
7
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
8
Vidarabine Approved, Investigational Phase 2 24356-66-9 21704 32326
9
alemtuzumab Approved, Investigational Phase 2 216503-57-0
10
Melphalan Approved Phase 2 148-82-3 460612 4053
11
Methylprednisolone Approved, Vet_approved Phase 2,Not Applicable 83-43-2 6741
12
Prednisolone Approved, Vet_approved Phase 2,Not Applicable 50-24-8 5755
13
Prednisone Approved, Vet_approved Phase 2,Not Applicable 53-03-2 5865
14 Vaccines Phase 2
15 Alkylating Agents Phase 2,Not Applicable
16 Anti-Infective Agents Phase 2,Not Applicable
17 Antimetabolites Phase 2,Not Applicable
18 Antimetabolites, Antineoplastic Phase 2,Not Applicable
19 Antirheumatic Agents Phase 2,Not Applicable
20 Antiviral Agents Phase 2
21 Immunosuppressive Agents Phase 2,Not Applicable
22 Vidarabine Phosphate Phase 2
23 Cyclosporins Phase 2,Not Applicable
24 Methylprednisolone acetate Phase 2,Not Applicable
25 Methylprednisolone Hemisuccinate Phase 2,Not Applicable
26 Prednisolone acetate Phase 2,Not Applicable
27 Prednisolone hemisuccinate Phase 2,Not Applicable
28 Prednisolone phosphate Phase 2,Not Applicable
29
Busulfan Approved, Investigational ,Not Applicable 55-98-1 2478
30
Mesna Approved, Investigational 3375-50-6 598
31
Etoposide Approved Not Applicable 33419-42-0 36462
32
Methotrexate Approved Not Applicable 1959-05-2, 59-05-2 126941
33
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
34
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
35
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
36 Protective Agents ,Not Applicable
37 Antiemetics Not Applicable
38 Antifungal Agents Not Applicable
39 Anti-Inflammatory Agents Not Applicable
40 Antilymphocyte Serum Not Applicable
41 Antineoplastic Agents, Hormonal Not Applicable
42 Antineoplastic Agents, Phytogenic Not Applicable
43 Autonomic Agents Not Applicable
44 Calcineurin Inhibitors Not Applicable
45 Complement System Proteins Not Applicable
46 Dermatologic Agents Not Applicable
47 Etoposide phosphate Not Applicable
48 Folic Acid Antagonists Not Applicable
49 Gastrointestinal Agents Not Applicable
50 glucocorticoids Not Applicable

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
2 A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Completed NCT01289847 Phase 4
3 Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency Diseases Completed NCT01963143 Phase 3
4 A Clinical Study of Intravenous Immunoglobulin Completed NCT00468273 Phase 3 Immune Globulin Intravenous (Human) Omr-IgG-am IGIV
5 Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases Completed NCT01884311 Phase 3
6 Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Completed NCT00730314 Phase 1, Phase 2
7 Study of Immune Responses and Safety of Recombinant Human CD40 Ligand in Patients With X-Linked Hyper-IgM Syndrome Completed NCT00001145 Phase 2 Bacteriophage;rhuCD40L;KLH
8 Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer Recruiting NCT03333486 Phase 2 Cyclophosphamide;Fludarabine Phosphate
9 Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) Active, not recruiting NCT01998633 Phase 2
10 Study of Genetic and Molecular Defects in Primary Immunodeficiency Disorders Unknown status NCT00004341 Not Applicable
11 Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies Recruiting NCT01652092 Alemtuzumab 0.3 mg;Cyclophosphamide;Busulfan;Fludarabine phosphate 40 mg;Melphalan;Alemtuzumab 0.2 mg;Busulfan;Fludarabine phosphate 30 mg;MESNA
12 Immune Regulation in Patients With Common Variable Immunodeficiency and Related Syndromes Recruiting NCT00001244
13 Molecular and Clinical Studies of Primary Immunodeficiency Diseases Enrolling by invitation NCT00006319
14 Studies of Disorders in Antibody Production and Related Primary Immunodeficiency States Terminated NCT00266513
15 Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies Terminated NCT00006054 Not Applicable anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;methotrexate;methylprednisolone;prednisone

Search NIH Clinical Center for Cd40 Ligand Deficiency

Cochrane evidence based reviews: hyper-igm immunodeficiency syndrome

Genetic Tests for Cd40 Ligand Deficiency

Genetic tests related to Cd40 Ligand Deficiency:

# Genetic test Affiliating Genes
1 Hyperimmunoglobulin M Syndrome 28

Anatomical Context for Cd40 Ligand Deficiency

MalaCards organs/tissues related to Cd40 Ligand Deficiency:

38
T Cells, B Cells, Liver, Bone, Bone Marrow

Publications for Cd40 Ligand Deficiency

Articles related to Cd40 Ligand Deficiency:

(show top 50) (show all 109)
# Title Authors Year
1
Successful sequential liver and haematopoietic stem cell transplantation in a child with CD40 ligand deficiency and Cryptosporidium-induced liver cirrhosis. ( 29377874 )
2018
2
Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome. ( 26903548 )
2016
3
Liver Transplantation in a Patient With CD40 Ligand Deficiency and Hyper-IgM Syndrome: Clinical and Immunological Assessments. ( 26762604 )
2016
4
X-linked Hyper IgM Syndrome Presenting as Pulmonary Alveolar Proteinosis. ( 27324886 )
2016
5
Human CD40 ligand deficiency dysregulates the macrophage transcriptome causing functional defects that are improved by exogenous IFN-I^. ( 27554817 )
2016
6
Hematopoietic Stem Cell Transplantation for CD40 Ligand Deficiency: Single Institution Experience. ( 26291959 )
2015
7
Clinical features and hematopoietic stem cell transplantations for CD40 ligand deficiency in Japan. ( 25840720 )
2015
8
X-linked hyper-IgM syndrome with eosinophilia in a male child: A case report. ( 25780430 )
2015
9
X-linked Hyper-IgM Syndrome with Bronchiectasis. ( 25328337 )
2014
10
A novel mutation in the CD40 ligand gene in a Chinese boy with X-linked hyper-IgM syndrome. ( 25268346 )
2014
11
X-linked hyper IgM syndrome: clinical, immunological and molecular features in patients from India. ( 24929972 )
2014
12
Clinical features and genetic analysis of 20 Chinese patients with X-linked hyper-IgM syndrome. ( 25215306 )
2014
13
Immunoglobulin class switch recombination deficiency type 1 or CD40 ligand deficiency: from bedside to bench and back again. ( 24308834 )
2014
14
Clinical and genetic analysis of patients with X-linked hyper-IgM syndrome. ( 22963373 )
2013
15
The polymorphism p.G219R of CD40L does not cause immunological alterations in vivo: conclusions from a X-linked hyper IgM syndrome kindred. ( 22750225 )
2012
16
CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome. ( 22459705 )
2012
17
X-linked hyper IgM syndrome: a novel sequence variant associated with an atypical mild phenotype. ( 22322937 )
2012
18
X-linked hyper-IgM syndrome with CD40LG mutation: Two case reports and literature review in Taiwanese patients. ( 23010537 )
2012
19
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. ( 22678466 )
2012
20
Pneumocystis jiroveci pneumonia revealing de novo mutation causing X-linked hyper-IgM syndrome in an infant male. The first case reported from French Guiana. ( 22983414 )
2012
21
Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand. ( 21841160 )
2011
22
CD40 ligand deficiency with grade III liver fibrosis, transplanted by a treosulphan-based conditioning regimen. ( 21967264 )
2011
23
Molecular diagnostic challenges and complex management of consecutive twin pregnancies in a family with CD40 ligand deficiency. ( 21958324 )
2011
24
Clinical and molecular characterization of X-linked hyper-IgM syndrome patients in China. ( 20591076 )
2010
25
Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting. ( 19023113 )
2009
26
Molecular characterization of patients with X-linked Hyper-IgM syndrome: description of two novel CD40L mutations. ( 19170966 )
2009
27
CD40 ligand deficiency: neurologic sequelae with radiographic correlation. ( 19931163 )
2009
28
Osteopenia in X-linked hyper-IgM syndrome reveals a regulatory role for CD40 ligand in osteoclastogenesis. ( 17360404 )
2007
29
X-linked hyper-IgM syndrome associated with a rapid course of multifocal leukoencephalopathy. ( 17296845 )
2007
30
Retrospective diagnosis of X-linked hyper-IgM syndrome in a family with multiple deaths of affected males. ( 17296592 )
2007
31
Successful management of neutropenia in a patient with CD40 ligand deficiency by immunoglobulin replacement therapy. ( 17303928 )
2007
32
X-linked hyper-IgM syndrome associated with poorly differentiated neuroendocrine tumor presenting as obstructive jaundice secondary to extensive adenopathy. ( 17436099 )
2007
33
Successful unrelated cord blood transplantation for a patient with CD40 ligand deficiency. ( 18056008 )
2007
34
JC virus granule cell neuronopathy in a child with CD40 ligand deficiency. ( 17352955 )
2007
35
Progressive multifocal leukoencephalopathy complicating X-linked hyper-IgM syndrome in an adult. ( 17106168 )
2006
36
De novo mutation causing X-linked hyper-IgM syndrome: a family study in Taiwan. ( 15997875 )
2005
37
Autoimmune retinopathy with RPE hypersensitivity and 'negative ERG' in X-linked hyper-IgM syndrome. ( 16019685 )
2005
38
Mutational screening of the CD40 ligand (CD40L) gene in patients with X linked hyper-IgM syndrome (XHIM) and determination of carrier status in female relatives. ( 15623492 )
2005
39
Successful Bone Marrow Transplantation in a Child with X-Linked Hyper-IgM Syndrome. ( 17642786 )
2004
40
Cutaneous sarcoid-like granulomas in a patient with X-linked hyper-IgM syndrome. ( 14871324 )
2004
41
Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993-2002. ( 14525761 )
2004
42
Coagulopathy in a patient with X-linked hyper-IgM syndrome who developed Kaposi's sarcoma. ( 14755382 )
2004
43
Flow cytometric diagnosis of X-linked hyper-IgM syndrome: application of an accurate and convenient procedure. ( 15167349 )
2004
44
Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency. ( 15273748 )
2004
45
Allogeneic hematopoietic stem cell transplantation for seven children with X-linked hyper-IgM syndrome: a single center experience. ( 15114594 )
2004
46
Pneumocystis carinii pneumonia as a presenting feature of X-linked hyper-IgM syndrome. ( 14629505 )
2003
47
[X-linked hyper-IGM syndrome associated to sclerosing cholangitis and gallbladder neoplasm: clinical case]. ( 12790080 )
2003
48
Three novel mutations reflect the variety of defects causing phenotypically diverse X-linked hyper-IgM syndrome. ( 12823286 )
2003
49
Complete recovery from Cryptosporidium parvum infection with gastroenteritis and sclerosing cholangitis after successful bone marrow transplantation in two brothers with X-linked hyper-IgM syndrome. ( 13130323 )
2003
50
The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. ( 14663287 )
2003

Variations for Cd40 Ligand Deficiency

ClinVar genetic disease variations for Cd40 Ligand Deficiency:

6 (show all 15)
# Gene Variation Type Significance SNP ID Assembly Location
1 CD40LG NM_000074.2(CD40LG): c.703G> C (p.Ala235Pro) single nucleotide variant Pathogenic rs104894771 GRCh37 Chromosome X, 135741491: 135741491
2 CD40LG NM_000074.2(CD40LG): c.680G> T (p.Gly227Val) single nucleotide variant Pathogenic rs104894768 GRCh37 Chromosome X, 135741468: 135741468
3 CD40LG NM_000074.2(CD40LG): c.464T> C (p.Leu155Pro) single nucleotide variant Pathogenic rs104894769 GRCh37 Chromosome X, 135741252: 135741252
4 CD40LG CD40LG, THR211ASP undetermined variant Pathogenic
5 CD40LG NM_000074.2(CD40LG): c.107T> G (p.Met36Arg) single nucleotide variant Pathogenic rs104894774 GRCh37 Chromosome X, 135730514: 135730514
6 CD40LG NM_000074.2(CD40LG): c.419G> A (p.Trp140Ter) single nucleotide variant Pathogenic rs104894775 GRCh37 Chromosome X, 135741207: 135741207
7 CD40LG NM_000074.2(CD40LG): c.418T> G (p.Trp140Gly) single nucleotide variant Pathogenic/Likely pathogenic rs104894777 GRCh37 Chromosome X, 135741206: 135741206
8 CD40LG CD40LG, 63-BP DEL deletion Pathogenic
9 CD40LG CD40LG, 8-BP DEL deletion Pathogenic
10 CD40LG CD40LG, 10-BP DEL deletion Pathogenic
11 CD40LG NM_000074.2(CD40LG): c.368C> A (p.Ala123Glu) single nucleotide variant Pathogenic rs104894778 GRCh37 Chromosome X, 135738536: 135738536
12 CD40LG CD40LG, 1-BP INS, TTT-TTTT, FS84TER insertion Pathogenic
13 CD40LG CD40LG, ALU INS, EX1 insertion Pathogenic
14 CD40LG NM_000074.2(CD40LG): c.31C> T (p.Arg11Ter) single nucleotide variant Pathogenic rs193922135 GRCh37 Chromosome X, 135730438: 135730438
15 CD40LG NM_000074.2(CD40LG): c.761C> T (p.Thr254Met) single nucleotide variant Pathogenic rs193922136 GRCh37 Chromosome X, 135741549: 135741549

Expression for Cd40 Ligand Deficiency

Search GEO for disease gene expression data for Cd40 Ligand Deficiency.

Pathways for Cd40 Ligand Deficiency

GO Terms for Cd40 Ligand Deficiency

Cellular components related to Cd40 Ligand Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD40 CD40LG CD79A

Biological processes related to Cd40 Ligand Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell activation GO:0042113 9.4 CD40 CD79A
2 positive regulation of interleukin-12 production GO:0032735 9.37 CD40 CD40LG
3 positive regulation of endothelial cell apoptotic process GO:2000353 9.32 CD40 CD40LG
4 isotype switching GO:0045190 9.26 AICDA CD40LG
5 regulation of immunoglobulin secretion GO:0051023 9.16 CD40 CD40LG
6 B cell differentiation GO:0030183 9.13 AICDA CD40LG CD79A
7 B cell proliferation GO:0042100 8.8 CD40 CD40LG CD79A

Sources for Cd40 Ligand Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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