MCID: CCM001
MIFTS: 38

Cecum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cecum Adenocarcinoma

MalaCards integrated aliases for Cecum Adenocarcinoma:

Name: Cecum Adenocarcinoma 12 14
Adenocarcinoma of Cecum 12 69
Cecal Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3039
NCIt 47 C5543
SNOMED-CT 64 413446001
UMLS 69 C1332866

Summaries for Cecum Adenocarcinoma

Disease Ontology : 12 A cecum carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Cecum Adenocarcinoma, also known as adenocarcinoma of cecum, is related to rhinosporidiosis and gastric adenocarcinoma, and has symptoms including abdominal pain and fever. An important gene associated with Cecum Adenocarcinoma is HMX2 (H6 Family Homeobox 2), and among its related pathways/superpathways are Pathways in cancer and Colorectal Cancer Metastasis. The drugs Fluorouracil and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and liver, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Related Diseases for Cecum Adenocarcinoma

Diseases related to Cecum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
id Related Disease Score Top Affiliating Genes
1 rhinosporidiosis 10.8 CDX2 KRT20
2 gastric adenocarcinoma 10.8 CDX2 KRT20
3 breast mucinous cystadenocarcinoma 10.7 CDX2 KRT20
4 childhood teratoma of the ovary 10.7 CDX2 KRT20
5 giant cell tumor 10.7 CDX2 KRT20
6 neuroendocrine tumor 10.7 CDX2 KRT20
7 pineal region meningioma 10.7 CDX2 SMUG1
8 tabes dorsalis 10.6 CDX2 KRT20
9 spinal cord ependymoma 10.6 CHGA SMUG1
10 stricture or kinking of ureter 10.6 CDX2 KRT20
11 gorlin bushkell jensen syndrome 10.6 CHGA KRT20
12 cystitis cystica 10.6 CHGA SMUG1
13 fibroma 10.6 CDX2 KRT20
14 aicardi-goutieres syndrome 10.6 CHGA SMUG1
15 factor xiii deficiency 10.6 MSH2 SMUG1
16 synovitis 10.6 CDX2 KRT7
17 auditory neuropathy 10.6 MSH2 MSH6
18 pediatric cns choriocarcinoma 10.6 KRT7 PMS1
19 bone giant cell tumor 10.5 KRT20 KRT7
20 rectum adenoma 10.5 KRT20 KRT7
21 bile duct mucinous adenocarcinoma 10.5 CDX2 KRT7
22 periosteal osteogenic sarcoma 10.5 KRT20 KRT7
23 steroid-induced glaucoma - borderline 10.5 KRT20 KRT7
24 stromal predominant kidney wilms' tumor 10.5 CDX2 KRT7
25 fallopian tube mucinous adenocarcinoma 10.5 KRT7 PMS1
26 clear cell squamous cell skin carcinoma 10.5 KRT20 KRT7
27 spastic ataxia 3 10.5 CDX2 KRT20
28 vulva squamous cell carcinoma 10.5 KRT20 KRT7
29 adenocarcinoma in situ 10.5 CDX2 KRT7
30 pyloric antrum cancer 10.5 CDX2 MLH1
31 lipid-cell variant infiltrating bladder urothelial carcinoma 10.5 KRT7 SMUG1
32 psoriasis 10.5 MLH1 MSH2
33 nodular nonsuppurative panniculitis 10.5 CHGA NODAL
34 testicular trophoblastic tumor 10.5 KRT20 KRT7
35 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 MLH1 MSH2
36 mesenchymoma 10.5 CDX2 CHGA KRT20
37 proliferative type fibrocystic change of breast 10.4 CDX2 KRT7
38 coronary aneurysm 10.4 KRT7 SMUG1
39 hordeolum 10.4 KRT20 KRT7
40 degenerative myopia 10.4 KRT20 KRT7
41 thyroid gland disease 10.4 MLH1 MSH2
42 breast secretory carcinoma 10.4 KRT20 KRT7
43 bronchiolo-alveolar adenocarcinoma 10.4 KRT7 SMUG1
44 retinal detachment 10.4 KRT20 KRT7
45 diffuse lipomatosis 10.4 CHGA KRT7
46 epidermolytic acanthoma 10.4 B2M MSH6
47 pemphigus vulgaris, familial 10.3 KRT20 KRT7
48 melanocytic nevus syndrome, congenital, somatic 10.3 MLH1 MSH2
49 ovarian mucinous adenocarcinoma 10.3 KRT20 KRT7
50 chronic neutrophilic leukemia 10.3 CDX2 KRT20 KRT7

Graphical network of the top 20 diseases related to Cecum Adenocarcinoma:



Diseases related to Cecum Adenocarcinoma

Symptoms & Phenotypes for Cecum Adenocarcinoma

UMLS symptoms related to Cecum Adenocarcinoma:


abdominal pain, fever

GenomeRNAi Phenotypes related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 MLH1 MSH2 MSH6 PMS1 SMUG1

MGI Mouse Phenotypes related to Cecum Adenocarcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 B2M CDX2 FGF2 KRT7 MLH1 MSH2
2 homeostasis/metabolism MP:0005376 9.9 KRT7 MLH1 MSH2 MSH6 NODAL SMUG1
3 mortality/aging MP:0010768 9.65 B2M CDX2 CHGA FGF2 HMX2 MLH1
4 neoplasm MP:0002006 9.23 B2M CDX2 FGF2 MLH1 MSH2 MSH6

Drugs & Therapeutics for Cecum Adenocarcinoma

Drugs for Cecum Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2,Phase 1 51-21-8 3385
2
Levoleucovorin Approved Phase 2,Phase 1 68538-85-2
3
leucovorin Approved, Nutraceutical Phase 2,Phase 1 58-05-9 143 6006
4 Alkylating Agents Phase 2
5 Anti-Bacterial Agents Phase 2
6 Antibiotics, Antitubercular Phase 2
7 Antidotes Phase 2,Phase 1
8 Antimetabolites Phase 2,Phase 1
9 Antimetabolites, Antineoplastic Phase 2,Phase 1
10 Calcium, Dietary Phase 2,Phase 1
11 Immunosuppressive Agents Phase 2,Phase 1
12 Mitomycins Phase 2
13 Nucleic Acid Synthesis Inhibitors Phase 2
14 Protective Agents Phase 2,Phase 1
15 Cola Nutraceutical Phase 2,Phase 1
16
Cetuximab Approved Phase 1 205923-56-4 56842117 2333
17
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
18
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
19
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
20
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
21
7-hydroxystaurosporine Experimental Phase 1 112953-11-4 72271
22
Camptothecin Experimental Phase 1 7689-03-4
23 Staurosporine Experimental Phase 1 62996-74-1
24 Antibodies Phase 1
25 Antibodies, Monoclonal Phase 1
26
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
27 Immunoglobulins Phase 1
28 Protein Kinase Inhibitors Phase 1
29 Adjuvants, Immunologic Phase 1
30 Albumin-Bound Paclitaxel Phase 1
31 Angiogenesis Inhibitors Phase 1
32 Angiogenesis Modulating Agents Phase 1
33 Antimitotic Agents Phase 1
34 Antineoplastic Agents, Phytogenic Phase 1
35 Interleukin-12 Phase 1
36 topoisomerase I inhibitors Phase 1
37 Topoisomerase Inhibitors Phase 1
38 Liver Extracts Phase 1
39 Etanidazole Investigational 22668-01-5
40 Motexafin lutetium Investigational 156436-90-7
41 Dermatologic Agents
42 Photosensitizing Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Fluorouracil With or Without Mitomycin in Treating Patients With Peritoneal Cancer Unknown status NCT00006112 Phase 2 chemotherapy;fluorouracil;leucovorin calcium;mitomycin C
2 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
3 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
4 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
5 Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
6 Comparison of Adenoma Detection Miss Rates at Colonoscopy Associated With Different Withdrawal Times Completed NCT01802008
7 Water-aided Colonoscopy vs Air Insufflation Colonoscopy in Colorectal Cancer Screening Completed NCT02041507
8 PillCam Colon Capsule and CT-colonography in the Evaluation of Patients With Incomplete Conventional Colonoscopy Completed NCT01525940
9 Knowledge, Attitudes, and Practice of Surgeons Toward Nutrition Support in HIPEC Patients Completed NCT02374411
10 EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer Terminated NCT00087191 EF5;motexafin lutetium

Search NIH Clinical Center for Cecum Adenocarcinoma

Genetic Tests for Cecum Adenocarcinoma

Anatomical Context for Cecum Adenocarcinoma

MalaCards organs/tissues related to Cecum Adenocarcinoma:

39
Lung, Breast, Liver, Colon

Publications for Cecum Adenocarcinoma

Articles related to Cecum Adenocarcinoma:

id Title Authors Year
1
Cecum adenocarcinoma as the first manifestation of Crohn's disease in a 24-year-old woman: dilemmas in differential diagnosis and management. ( 21457632 )
2010
2
Inferior vena cava obstruction due to cecum adenocarcinoma. ( 17189847 )
2007
3
Minimal change nephrotic syndrome with cecum adenocarcinoma. ( 8861804 )
1996

Variations for Cecum Adenocarcinoma

Expression for Cecum Adenocarcinoma

Search GEO for disease gene expression data for Cecum Adenocarcinoma.

Pathways for Cecum Adenocarcinoma

GO Terms for Cecum Adenocarcinoma

Cellular components related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 8.96 MLH1 PMS1
2 MutSalpha complex GO:0032301 8.62 MSH2 MSH6

Biological processes related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.88 MLH1 MSH2 MSH6 PMS1 SMUG1
2 DNA repair GO:0006281 9.77 MLH1 MSH2 MSH6 PMS1 SMUG1
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 MLH1 MSH2 MSH6
4 anterior/posterior axis specification GO:0009948 9.56 CDX2 NODAL
5 trophectodermal cell differentiation GO:0001829 9.55 CDX2 NODAL
6 determination of adult lifespan GO:0008340 9.54 MSH2 MSH6
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.52 MLH1 MSH2
8 negative regulation of DNA recombination GO:0045910 9.51 MSH2 MSH6
9 positive regulation of helicase activity GO:0051096 9.49 MSH2 MSH6
10 maintenance of DNA repeat elements GO:0043570 9.46 MSH2 MSH6
11 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MLH1 MSH2
12 somatic hypermutation of immunoglobulin genes GO:0016446 9.43 MLH1 MSH2 MSH6
13 isotype switching GO:0045190 9.33 MLH1 MSH2 MSH6
14 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
15 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS1
16 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MLH1 MSH2 MSH6

Molecular functions related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.71 MLH1 MSH2 MSH6 PMS1
2 double-stranded DNA binding GO:0003690 9.63 CDX2 MSH2 MSH6
3 single-stranded DNA binding GO:0003697 9.61 MLH1 MSH2 PMS1
4 four-way junction DNA binding GO:0000400 9.48 MSH2 MSH6
5 MutLalpha complex binding GO:0032405 9.37 MSH2 MSH6
6 oxidized purine DNA binding GO:0032357 9.32 MSH2 MSH6
7 single guanine insertion binding GO:0032142 9.26 MSH2 MSH6
8 single thymine insertion binding GO:0032143 9.16 MSH2 MSH6
9 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
10 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS1

Sources for Cecum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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