Aliases & Classifications for Cecum Adenocarcinoma

MalaCards integrated aliases for Cecum Adenocarcinoma:

Name: Cecum Adenocarcinoma 12 14
Adenocarcinoma of Cecum 12 69
Cecal Adenocarcinoma 12

Classifications:



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Disease Ontology 12 DOID:3039
NCIt 46 C5543
SNOMED-CT 64 413446001
UMLS 69 C1332866

Summaries for Cecum Adenocarcinoma

Disease Ontology : 12 A cecum carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Cecum Adenocarcinoma, also known as adenocarcinoma of cecum, is related to adenocarcinoma and mucinous adenofibroma, and has symptoms including fever and abdominal pain. An important gene associated with Cecum Adenocarcinoma is HMX2 (H6 Family Homeobox 2), and among its related pathways/superpathways are Endometrial cancer and TCR Signaling (Qiagen). Related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cellular

Related Diseases for Cecum Adenocarcinoma

Diseases related to Cecum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.5 HRAS KRAS MLH1 MSH2
2 mucinous adenofibroma 10.6 CDX2 KRT7
3 cervical adenoma malignum 10.6 KRT7 PMS1
4 cystic basal cell carcinoma 10.6 KRT20 KRT7
5 lung acinar adenocarcinoma 10.6 KRT20 KRT7
6 seminal vesicle adenocarcinoma 10.5 KRT20 KRT7
7 transverse colon cancer 10.5 KRT20 KRT7
8 eyelid neoplasm 10.5 KRT20 KRT7
9 malignant syringoma 10.5 KRT20 KRT7
10 krukenberg carcinoma 10.5 KRT20 KRT7
11 large intestine adenocarcinoma 10.5 KRT20 KRT7
12 linitis plastica 10.5 KRT20 KRT7
13 adenoid squamous cell carcinoma 10.5 KRT20 KRT7
14 cervical mucinous adenocarcinoma 10.5 KRT7 PMS1
15 eccrine sweat gland neoplasm 10.5 KRT20 KRT7
16 malignant spiradenoma 10.5 KRT7 SMUG1
17 adenoma of the pancreas 10.5 CHGA KRT20
18 epithelial predominant wilms' tumor 10.5 CDX2 KRT7
19 vulval paget's disease 10.4 KRT20 KRT7
20 glandular cystitis 10.4 CDX2 KRT20 KRT7
21 mucinous bronchioloalveolar adenocarcinoma 10.4 CDX2 KRT20 KRT7
22 bladder adenocarcinoma 10.4 CDX2 KRT20 KRT7
23 ovarian mucinous adenocarcinoma 10.4 CDX2 KRT20 KRT7
24 thymus adenocarcinoma 10.4 CDX2 KRT20 KRT7
25 gastric diffuse adenocarcinoma 10.4 CDX2 KRT20 KRT7
26 vulva adenocarcinoma 10.4 CDX2 KRT20 KRT7
27 chronic cystitis 10.4 CDX2 KRT20 KRT7
28 rectum adenocarcinoma 10.4 CDX2 KRT20 KRT7
29 ampulla of vater adenocarcinoma 10.4 CDX2 KRT20 KRT7
30 endocervical adenocarcinoma 10.4 CDX2 KRT20 KRT7
31 ovarian mucinous neoplasm 10.4 CDX2 KRT20 KRT7
32 cystic teratoma 10.4 CDX2 KRT20 KRT7
33 sigmoid neoplasm 10.4 HRAS KRAS
34 extraosseous osteosarcoma 10.4 KRT7 SMUG1
35 cystitis cystica 10.4 CDX2 KRT20 KRT7
36 bile duct cystadenocarcinoma 10.4 KRT20 KRT7
37 secretory meningioma 10.4 CDX2 KRT20 KRT7
38 anal canal adenocarcinoma 10.4 CDX2 KRAS KRT7
39 bronchiolo-alveolar adenocarcinoma 10.4 CDX2 KRAS KRT7
40 apocrine adenoma 10.4 HRAS KRAS
41 intestinal obstruction 10.4 CDX2 KRT20 KRT7
42 cervical adenocarcinoma 10.4 CDX2 KRT20 KRT7
43 periampullary adenoma 10.4 HRAS KRAS
44 bile duct carcinoma 10.4 CDX2 KRT20 KRT7
45 teratoma 10.4 CDX2 KRT20 KRT7
46 cellular ependymoma 10.4 CHGA SMUG1
47 schimmelpenning-feuerstein-mims syndrome 10.4 HRAS KRAS
48 gallbladder small cell carcinoma 10.4 CHGA SMUG1
49 goblet cell carcinoid 10.4 CHGA KRT20
50 pancreatic serous cystadenoma 10.4 CHGA KRT7

Graphical network of the top 20 diseases related to Cecum Adenocarcinoma:



Diseases related to Cecum Adenocarcinoma

Symptoms & Phenotypes for Cecum Adenocarcinoma

UMLS symptoms related to Cecum Adenocarcinoma:


fever, abdominal pain

GenomeRNAi Phenotypes related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 MSH6 RNGTT CDX2 KRAS MLH1

MGI Mouse Phenotypes related to Cecum Adenocarcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 NODAL SMUG1 KRAS KRT7 B2M MLH1
2 homeostasis/metabolism MP:0005376 9.97 HMX2 HRAS SMUG1 KRAS KRT7 B2M
3 digestive/alimentary MP:0005381 9.8 NODAL HRAS KRAS B2M MLH1 CDX2
4 mortality/aging MP:0010768 9.73 HMX2 HRAS SMUG1 KRAS B2M MLH1
5 neoplasm MP:0002006 9.32 HRAS PMS1 SMUG1 KRAS B2M MLH1

Drugs & Therapeutics for Cecum Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cecum Adenocarcinoma

Genetic Tests for Cecum Adenocarcinoma

Anatomical Context for Cecum Adenocarcinoma

Publications for Cecum Adenocarcinoma

Articles related to Cecum Adenocarcinoma:

# Title Authors Year
1
Cecum adenocarcinoma as the first manifestation of Crohn's disease in a 24-year-old woman: dilemmas in differential diagnosis and management. ( 21457632 )
2010
2
Inferior vena cava obstruction due to cecum adenocarcinoma. ( 17189847 )
2007
3
Minimal change nephrotic syndrome with cecum adenocarcinoma. ( 8861804 )
1996

Variations for Cecum Adenocarcinoma

Expression for Cecum Adenocarcinoma

Search GEO for disease gene expression data for Cecum Adenocarcinoma.

Pathways for Cecum Adenocarcinoma

Pathways related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 FGF2 HRAS KRAS MLH1 MSH2 MSH6
2
Show member pathways
12.69 HRAS KRAS MLH1 MSH2 MSH6
3
Show member pathways
12.5 CDX2 FGF2 HRAS KRAS MLH1
4
Show member pathways
12.36 FGF2 HRAS KRAS MSH2
5 12.16 FGF2 HRAS KRAS MLH1 MSH2 MSH6
6 11.89 KRAS MLH1 MSH2 MSH6
7 11.7 FGF2 HRAS KRAS NODAL
8
Show member pathways
11.61 FGF2 HRAS KRAS
9 11.5 MLH1 MSH2 MSH6
10 11.12 FGF2 HRAS KRAS
11
Show member pathways
10.92 MLH1 MSH2 MSH6 PMS1
12 10.79 MLH1 MSH2 MSH6
13 10.61 HRAS KRAS

GO Terms for Cecum Adenocarcinoma

Cellular components related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 MLH1 PMS1
2 mismatch repair complex GO:0032300 8.96 MLH1 MSH2
3 MutSalpha complex GO:0032301 8.62 MSH2 MSH6

Biological processes related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.93 MLH1 MSH2 MSH6 PMS1 SMUG1
2 DNA repair GO:0006281 9.8 MLH1 MSH2 MSH6 PMS1 SMUG1
3 positive regulation of cell proliferation GO:0008284 9.8 CDX2 FGF2 HMX2 HRAS KRAS NODAL
4 animal organ morphogenesis GO:0009887 9.77 CDX2 FGF2 HRAS
5 Ras protein signal transduction GO:0007265 9.72 FGF2 HRAS KRAS
6 positive regulation of MAP kinase activity GO:0043406 9.7 FGF2 HRAS KRAS
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.65 MLH1 MSH2 MSH6
8 anterior/posterior axis specification GO:0009948 9.6 CDX2 NODAL
9 trophectodermal cell differentiation GO:0001829 9.58 CDX2 NODAL
10 determination of adult lifespan GO:0008340 9.58 MSH2 MSH6
11 positive regulation of isotype switching to IgG isotypes GO:0048304 9.57 MLH1 MSH2
12 response to isolation stress GO:0035900 9.56 HRAS KRAS
13 positive regulation of helicase activity GO:0051096 9.51 MSH2 MSH6
14 negative regulation of DNA recombination GO:0045910 9.49 MSH2 MSH6
15 maintenance of DNA repeat elements GO:0043570 9.46 MSH2 MSH6
16 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MLH1 MSH2
17 somatic hypermutation of immunoglobulin genes GO:0016446 9.43 MLH1 MSH2 MSH6
18 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MLH1 MSH2
19 isotype switching GO:0045190 9.33 MLH1 MSH2 MSH6
20 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS1
21 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MLH1 MSH2 MSH6

Molecular functions related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.71 MLH1 MSH2 MSH6 PMS1
2 double-stranded DNA binding GO:0003690 9.65 CDX2 MSH2 MSH6
3 single-stranded DNA binding GO:0003697 9.61 MLH1 MSH2 PMS1
4 four-way junction DNA binding GO:0000400 9.46 MSH2 MSH6
5 oxidized purine DNA binding GO:0032357 9.37 MSH2 MSH6
6 MutLalpha complex binding GO:0032405 9.32 MSH2 MSH6
7 single guanine insertion binding GO:0032142 9.26 MSH2 MSH6
8 single thymine insertion binding GO:0032143 9.16 MSH2 MSH6
9 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
10 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS1

Sources for Cecum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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