Summaries for Celiac Disease

Sources:
6Disease Ontology, 23MedlinePlus, 17Genetics Home Reference, 15GeneReviews, 33OMIM, 22MalaCards
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Export this MalaCard
MedlinePlus: If you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. gluten is a protein in wheat, rye and barley. it is found mainly in foods but may also be in other products like medicines, vitamins and even the glue on stamps and envelopes. celiac disease affects each person differently. symptoms may occur in the digestive system, or in other parts of the body. one person might have diarrhea and abdominal pain, while another person may be irritable or depressed. irritability is one of the most common symptoms in children. some people have no symptoms. celiac disease is genetic. blood tests can help your doctor diagnose the disease. your doctor may also need to examine a small piece of tissue from your small intestine. treatment is a diet free of gluten. nih: national institute of diabetes and digestive and kidney diseases23

MalaCards: Celiac Disease, also known as coeliac disease, is related to type 1 diabetes mellitus and autoimmune thyroiditis, and has symptoms including nausea, loss of appetite and abdominal pain. An important gene associated with Celiac Disease is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Immune System and Antigen processing and presentation. The drug mct and the compounds carbohydrates and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include small intestine to gliadin, liver and kidney, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology: A food allergy that is caused by a reaction located in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe triticeae. the disease is associated with hla-dq gene. it has symptom abdominal pain, has symptom constipation, has symptom diarrhea, has symptom nausea and vomiting, and has symptom loss of appetite.6

Genetics Home Reference: Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.17

Wikipedia: Coeliac disease (pron.: /ˈsiːli.æk/; spelled celiac disease in North America and often celiac sprue)...44 more...

OMIM: 212750

GeneReviews summary for celiac

Aliases & Descriptions for Celiac Disease

Sources:
43UMLS, 6Disease Ontology, 7diseasecard, 44Wikipedia, 15GeneReviews, 17Genetics Home Reference, 8DISEASES, 33OMIM, 32Novoseek , 23MedlinePlus, 16GeneTests, 40SNOMED-CT, 24MeSH, 19ICD9CM, 27NCIt
See all sources

Aliases & Descriptions:

celiac disease 6 7 44 15 17 8 33 32 23 43
coeliac disease 6 15 16
celiac sprue 6 15 16
gluten-sensitive enteropathy 15 16
celiac disease (disorder) 6 16
nontropical sprue 15 16
celiac disease nos (disorder) 6
steatorrhoea - idiopathic 6
idiopathic steatorrhea 6
gluten enteropathy 17
steatorrhea 43
sprue 17

Related Diseases for Celiac Disease

Sources:
13GeneCards, 14GeneDecks
See all sources

Disease types for celiac disease family:

celiac disease 4 celiac disease 10
celiac disease 13 celiac disease 6
celiac disease 7 celiac disease 9
celiac disease 11 celiac disease 12
celiac disease 2 celiac disease 5
celiac disease 8 celiac disease 3

Diseases related to celiac disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1002)
idRelated DiseaseScoreTop Affiliating Genes
1type 1 diabetes mellitus33.7KIR3DL1, VDR, BGLAP, SCT, LEP, CIITA
2autoimmune thyroiditis32.8CIITA, CHKB, CD80, IL12B, IL2RA, IL4
3hemochromatosis32.2MT-CYB, CALR, HP, HLA-B, HEPH, HFE
4dermatitis herpetiformis31.4SELE, MYO9B, CD79A, CD40LG, MMP12, MMP3
5primary biliary cirrhosis31.2SELL, VDR, BGLAP, SCT, CIITA, CD79A
6giardiasis30.7SCT, LCT, CD79A, GZMB, ENO1, TGFB1
7eosinophilic esophagitis30.5MUC5AC, IL10, IL5, CCR3, IFNG, HLA-DQA1
8crohn's disease30.2MUC2, CD80, FOXP3, MLN, IRF1, MIF
9turner syndrome30.1BGLAP, IGF1, TPO, DMD, CYP21A2, TG
10hodgkin's lymphoma30.0REL, CD28, CD80, CD247, ITGA4, GZMB
11collagenous colitis29.7CD79A, CD40LG, NOD2, NOS2, RNASE3, TG
12psoriatic arthritis29.6IL10, IL1B, IL1RN, IL6, TNF, NOD2
13non-hodgkin lymphoma29.6SELL, VDR, BACH2, CD28, CD14, CD80
14immunodeficiency29.5KIR3DL1, SELL, CIITA, CD209, CD28, CD79A
15hepatitis29.5GZMB, GSR, FASLG, FAS, GPT, IFNA2
16multiple sclerosis29.4ZMIZ1, CLEC16A, UBD, CD14, CD226, MICB
17ulcerative colitis29.2SELE, SELL, BGLAP, CHKB, MUC2, CD28
18addison's disease29.2VDR, CLEC16A, BGLAP, CD79A, CD226, FOXP3
19arthritis29.2SELL, MMP3, IL17A, IL1A, IL1B, IL6
20eosinophilic gastroenteritis29.2IL5, ALB, RNASE3, PRG2, CSN1S1
21iron deficiency anemia29.1GSR, ALB, GHRL, TNF, HEPH, HFE
22pure red-cell aplasia29.1CD79A, CD40LG, GZMB, IL2, IL2RA, F2
23rheumatoid arthritis29.0IL1RN, MBL2, HLA-DRB1, CRP, LTA
24inflammatory bowel disease28.8SELE, SELL, VDR, MYO9B, BGLAP, SCT
25short stature28.6VDR, BGLAP, PARK7, LEP, CD36, FLNB
26diabetes mellitus28.5SH2B3, REG1A, KIR3DL1, SELE, SELL, VDR
27gastroenteritis28.4LCT, CD79A, MLN, IL10, IL1B, IL1RN
28diarrhea28.4KCNJ11, SCT, LCT, CD79A, CD14, CD40LG
29schizophrenia28.2MTHFR, MICB, IL1B, IL1RN, IL2, IL4
30rickets28.1VDR, BGLAP, CD36, IGF1, ALB, CALCA
31short bowel syndrome27.8LEP, CD79A, IL1B, CCK, IGF1, F3
32hyperhomocysteinemia27.8SELE, MTHFR, INS, GSR, IL18, IL1B
33systemic lupus erythematosus27.8SELE, CIITA, CD28, CD79A, CD40LG, CD80
34alopecia areata27.6VDR, CIITA, CD79A, GZMB, MICA, MIF
35duodenitis27.5VDR, SCG5, SCT, LEP, MUC2, MUC5AC
36thyroiditis27.2SELE, SEPP1, VDR, CLEC16A, BGLAP, PARK7
37cholangitis27.2REL, KIR3DL1, SCT, MUC2, ATG16L1, CD28
38thrombocytosis27.1MTHFR, CD79A, CD40LG, IL1A, IL1B, IL4
39irritable bowel syndrome27.0LEP, LCT, CD79A, CD40LG, MLN, IL10
40hepatitis c27.0CIITA, CD28, CD40LG, IRF1, GSR, IL10
41common variable immunodeficiency26.9SELL, BGLAP, CD28, CD79A, CD36, CD40LG
42spontaneous abortion26.4KIR3DL1, KIR2DL5A, MTHFR, CD40LG, FOXP3, GSR
43alopecia26.4LPP, VDR, CIITA, CD79A, GZMB, MICA
44down syndrome25.7REG1A, LEP, MTHFR, S100B, CD79A, CD36
45dermatitis25.4REL, SELE, SELL, MYO9B, BGLAP, LEP
46twinning25.1VDR, BGLAP, LEP, MTHFR, MT-CYB, CD79A
47psoriasis24.7KIR3DL1, KIR2DL5A, SELE, VDR, BGLAP, LEP
48infertility24.6SEPP1, PARK7, LEP, MTHFR, CD79A, FOXP3
49anemia24.2SELE, SELL, VDR, SCT, LEP, CHKB
50lupus erythematosus24.0SH2B3, REL, KIR3DL1, KIR2DL5A, SELE, SELL

Graphical network of the top 20 diseases related to celiac disease:



Graphical network of diseases related to celiac disease

Clinical Features for Celiac Disease

Sources:
33OMIM, 6Disease Ontology
See all sources
Clinical features from OMIM: 212750
Symptoms: nausea, loss of appetite, abdominal pain, constipation, diarrhea.6

Drugs & Therapeutics for Celiac Disease

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for celiac disease

Drug clinical trials:

Search ClinicalTrials for celiac disease

Search NIH Clinical Center for celiac disease

Search CenterWatch for celiac disease

Inferred drug relations via UMLS/NDF-RT:

43 28 mct

Genetic Tests for Celiac Disease

Sources:
16GeneTests
See all sources

Genetic tests related to celiac disease:

id Genetic test Affiliating Genes
1 Celiac Disease
clinical/research
HLA-DQA1, HLA-DQB1

Anatomical Context for Celiac Disease

Sources:
22MalaCards, 11FMA
See all sources

MalaCards organs/tissues related to celiac disease:

22
Liver, Kidney, Heart, Small intestine, Thyroid, Monocytes, T cells, B cells, Pancreatic islet

FMA organs/tissues related to celiac disease:

11
Small intestine to gliadin

Phenotypes for genes affiliated with Celiac Disease

Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to celiac disease:

25 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:000539712.4SH2B3, MYO9B, ZMIZ1, ZFP36L1, UBASH3A, BACH2
2immune system phenotypeMP:000538711.1REL, SELL, SERPINE2, VDR, MYO9B, ZFP36L1
3respiratory system phenotypeMP:000538810.3REL, SELL, PBX3, SCG5, CD14, IL12A
4renal/urinary system phenotypeMP:000536710.2SCHIP1, INS, CCR1, TNFAIP3, DMD, PLA2G4A
5endocrine/exocrine gland phenotypeMP:000537910.2REG1A, SELL, SERPINE2, KCNJ11, SCG5, SCHIP1
6no phenotypic analysisMP:00030129.6SERPINE2, KCNJ11, MTHFR, CD209, CD79A, FOXP3
7mortality/agingMP:00107689.5REL, SELE, SEPP1, NAGS, LPP, VDR
8liver/biliary system phenotypeMP:00053709.4REL, SEPP1, SCG5, ATXN2, CD36, INS
9nervous system phenotypeMP:00036319.4REL, SERPINE2, ZFP36L1, PBX3, KCNJ11, SCG5
10integument phenotypeMP:00107719.3REL, NAGS, ZMIZ1, PBX3, KCNJ11, SCG5
11growth/size phenotypeMP:00053789.2REL, SELE, SEPP1, NAGS, VDR, ZMIZ1
12digestive/alimentary phenotypeMP:00053818.7REL, VDR, PBX3, SCHIP1, LEP, MUC2
13skeleton phenotypeMP:00053908.1REL, VDR, PBX3, SCHIP1, LEP, MTHFR
14reproductive system phenotypeMP:00053898.0REG1A, SERPINE2, SEPP1, VDR, SCHIP1, LEP
15adipose tissue phenotypeMP:00053757.8KCNJ11, SCG5, LEP, ATXN2, CD36, CD14
16behavior/neurological phenotypeMP:00053867.7SELE, SERPINE2, SEPP1, NAGS, PBX3, PARK7
17normal phenotypeMP:00028737.6SELE, MYO9B, CIITA, UBASH3A, LALBA, S100B
18tumorigenesisMP:00020067.4SELL, ZFP36L1, LEP, MUC2, CD226, GZMB
19homeostasis/metabolism phenotypeMP:00053766.8REG1A, REL, SELE, SELL, SERPINE2, SEPP1
20cellular phenotypeMP:00053846.8SH2B3, REL, SELE, SELL, SERPINE2, SEPP1
21muscle phenotypeMP:00053696.5ZFP36L1, KCNJ11, SCHIP1, LEP, CHKB, CD36
22vision/eye phenotypeMP:00053915.6SELE, LEP, MTHFR, CD36, FOXP3, INS
23cardiovascular system phenotypeMP:00053855.5REL, SELE, SELL, VDR, ZMIZ1, ZFP36L1

Publications for genes affiliated with Celiac Disease

Sources:
35PubMed
See all sources

Articles related to celiac disease:

(show top 50)    (show all 397)
idTitleAuthorsYearAffiliating Genes
1Docosahexaenoic acid modulates in vitro the inflammat ion of celiac disease in intestinal epithelial cells via the inhibition of cPLA 2. (21421277)Vincentini O.... Silano M.2011PTGS2
2DNAM-1 mediates epithelial cell-specific cytotoxicity of aberrant intraepithelial lymphocyte lines from refractory celiac disease ty pe II patients. (21525383)Tjon J.M.... Koning F.2011CD226
3Multiple independent variants in 6q21-22 associated w ith susceptibility to celiac disease in the Dutch, Finnish and Hungarian popula tions. (21326284)Einarsdottir E.... Saavalainen P.2011HACE1
4IgA-class autoantibodies against neuronal transglutam inase, TG6 in celiac disease: no evidence for gluten dependency. (21453693)Lindfors K.... Kaukinen K.2011TGM6
5Altered expression of the lymphocyte activation antig en CD30 in active celiac disease. (20166880)Periolo N.... CherA+avsky A.C.2010TNFRSF8, IL15
6Diagnostic testing for celiac disease among patients with abdominal symptoms: a systematic review. (20442390)van der Windt D.A.... van der Horst H.E.2010CD79A
7Enzymatic detoxification of gluten by germinating wheat proteases: implications for new treatment of celiac disease. (19353359)Stenman S.M.... MAoki M.2009TJP1
8Performance of serology assays for diagnosing celiac disease in a clinical setting. (19776198)Parizade M.... Shainberg B.2009CD79A
9In vitro differentiation of human monocytes into dendritic cells by peptic-tryptic digest of gliadin is independent of genetic predisposition and the presence of celiac disease. (18696220)Rakhimova M.... Dieterich W.2009CD83
10Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic ba ckground for ulcerative colitis and celiac disease. (19455118)Glas J.... Brand S.2009KIAA1109
11Involvement of interleukin-15 and interleukin-21, two gamma-chain-related cytokines, in celiac disease. (19787822)De Nitto D.... Monteleone G.2009IL15
12Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease. (19248194)Hadithi M.... Smulders Y.M.2009MTHFR
13Clinical presentation of celiac disease and the diagnostic accuracy of serologic markers in children. (18923841)Lurz E.... Schibli S.2009CD79A
14Linkage and association study of FcgammaR polymorphisms in celiac disease. (19140833)Sareneva I.... Einarsdottir E.2009FCGR3A, FCGR2A
15Diverse foxp3 expression in children with type 1 diabetes and celiac disease. (19120312)Kivling A.... FaresjAP M.2008FOXP3
16An autosomal genome-wide screen for celiac disease in Bedouin families. (17943142)Ding Y.C.... Neuhausen S.L.2008CELIAC2
17Autoantibodies in celiac disease. (18176861)Alaedini A.... Green P.H.2008TGM2, CALR, TGM3
18A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. (17558408)van Heel D.A.... Wijmenga C.2007IL2, HLA-DQA1, IL21
19New aspects in celiac disease. (17451193)Torres M.I.... RA-os A.2007HLA-G
20Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation. (17570212)Olaussen R.W.... Farstad I.N.2007CCR9
21Protein expression profile of celiac disease patient with aberrant T cell by two-dimensional difference gel electrophoresis. (17785332)De Re V.... Cannizzaro R.2007CD40LG
22Prevalence of celiac disease in patients with autoimmune thyroiditis. (18091661)Iuorio R.... Picarelli A.2007TPO
23Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4. (17215859)Santin I.... Bilbao J.R.2007KIR2DL5A, KIR2DL5B
24Celiac disease screening by immunochromatographic visual assays: results of a multicenter study. (18030231)Baviera L.C.... Koninckx C.R.2007CD79A
25Celiac disease. (18217518)Presutti R.J.... Hill D.A.2007CD79A
26Enteric glial-derived S100B protein stimulates nitric oxide production in celiac disease. (17678654)Esposito G.... Cuomo R.2007S100B, NOS2
27The SPINK gene family and celiac disease susceptibility. (17333166)Wapenaar M.C.... Wijmenga C.2007SPINK5, SPINK1, SPINK2
28HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. (16878175)Tollefsen S.... Sollid L.M.2006TGM2, HLA-DQA1, HLA-DQB1
29Insights in the laboratory diagnosis of celiac disease. (16898183)Basso D.... Plebani M.2006TGM2
30Celiac disease in North Italian patients with autoimmune Addison's disease. (16452541)Betterle C.... Albergoni M.2006CD79A
31Nutritional status in adolescents and young adults wi th screen-detected celiac disease. (15861017)Haapalahti M.... Kokkonen J.2005TFRC
32Adaptive and innate immune responses in celiac disease. (15876458)Gianfrani C.... Troncone R.2005IL15
33Immunochromatographic sticks for tissue transglutaminase and antigliadin antibody screening in celiac disease. (15181616)Ferre-LA^pez S.... MAcndez E.2004TGM2, CD79A
34No association of CTLA4 gene with celiac disease in the Basque population. (12883299)MartA-n-Pagola A.... CastaA+o L.2003CTLA4
35HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. (12651074)Karell K.... Partanen J.2003HLA-DQA1, HLA-DQB1, HLA-DRB1
36Plasma motilin in untreated celiac disease. (12732349)Sjolund K.... Ekman R.2003MLN
37On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. (12675238)Koch S.... Sjostrom H.2003DPP4
38HLA-DQA1 and HLA-DQB1 genetic markers and clinical presentation in celiac disease. (12050583)Zubillaga P.... Vitoria J.C.2002HLA-DQA1, HLA-DQB1
39The role of hemochromatosis susceptibility gene mutations in protecting against iron deficiency in celiac disease. (12145797)Butterworth J.R.... Iqbal T.H.2002HLA-A, HLA-DRB1, HFE
40Pediatric celiac disease in India is associated with multiple DR3-DQ2 haplotypes. (12121676)Kaur G.... Mehra N.K.2002HLA-DQA1, HLA-DQB1, HLA-DRB1
41Splenic thrombosis and celiac disease: a fortuitous association? (11244621)AndrA"s E.... Geisler F.2000MTHFR
42Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation. (10029615)Halttunen T.... MAoki M.1999CD79A
43Improved method for serological testing in celiac disease--IgA anti-endomysium antibody test: a comparison between monkey oesophagus and human umbilical cord as substrate in indirect immunofluorescence test. (9890337)Amara W.... Husebekk A.1998CD79A
44Sucrosemia in untreated celiac disease: a potential s creening test. (9590427)Cox M.A.... Cooper B.T.1998SI
45Presence of inducible nitric oxide synthase, nitrotyrosine, CD68, and CD14 in the small intestine in celiac disease. (9251676)er Steege J.... Forget P.1997NOS2
46Synergistic effect of two HLA heterodimers in the sus ceptibility to celiac disease in Tunisia. (9271713)Bouguerra F.... Clerget-Darpoux F.1997HLA-DRB4
47Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis. (8623906)Oberhuber G.... Radaszkiewicz T.1996GZMB
48Is small bowel biopsy necessary in adults with suspected celiac disease and IgA anti-endomysium antibodies? 100% positive predictive value for celiac disease in adults. (8565771)Valdimarsson T.... StrAPm M.1996CD79A
49Association of celiac disease with microsatellite polymorphisms close to the tumor necrosis factor genes. (8655356)McManus R.... Kelleher D.1996TNF
50A family study confirms that the HLA-DP associations with celiac disease are the result of an extended HLA-DR3 haplotype. (1676703)Bolsover W.J.... Ciclitira P.J.1991HLA-DPA1

Expression for genes affiliated with Celiac Disease

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Celiac Disease

Pathways for genes affiliated with Celiac Disease

Sources:
38Reactome, 20KEGG, 36QIAGEN, 41Thomson Reuters, 10EMD Millipore, 37R&D Systems
See all sources

Pathways related to celiac disease according to GeneDecks:

(show top 50)    (show all 140)
idPathwayScoreTop Affiliating Genes
1Immune System3811.8REL, KIR3DL1, CIITA, S100B, CD79A, CD226
2Antigen processing and presentation2011.8KIR3DL1, KIR2DL5A, CIITA, CD8A, HSPA1B, HLA-C
3Phagosome2011.6CD209, CD36, CD14, FCGR2A, FCGR3A, MBL2
4CTL Mediated Apoptosis3611.4GZMB, HLA-A, HLA-B, HLA-C, HLA-DMB, HLA-DPA1
5Cell adhesion molecules (CAMs)2011.3SELL, CD28, CD8A, CD80, CD226, ITGA4
6Immune response_IL-22 signaling pathway4111.3CD28, IL12A, IL12B, IL2, IL22, IL2RA
7Immune response IL-22 signaling pathway1011.3CD28, IL12A, IL12B, IL2, IL22, IL2RA
8Immune response_ICOS pathway in T-helper cell4111.2REL, ICOSLG, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA2
9RAR-Gamma-RXR-Alpha Degradation3611.2UBD, CD80, GTF2A1, IL12A, IL15, IL2
10MHC class II antigen presentation3811.2ENSG00000233209, ENSG00000232062, ENSG00000206305, HLA-DPA1, HLA-DPB1, HLA-DQA1
11Graft-versus-host disease2011.0KIR3DL1, KIR2DL5A, CD28, CD80, IL1A, IL2
12Viral myocarditis2010.9CD28, CD40LG, CD80, ICAM1, HLA-A, HLA-B
13Intestinal immune network for IgA production2010.7CD28, CD40LG, CD80, ITGA4, IL10, IL15
14Asthma2010.5CD40LG, IL10, IL4, IL5, HLA-DMB, HLA-DPA1
15Molecular Mechanisms of Cancer3610.5CD80, ITGA4, ITGAE, IL12B, IL15, IL2
16Akt Signaling3610.4CD28, CD80, ITGAE, IL10, IL12B, IL15
17STAT3 Pathway3610.4CD28, CD80, IL10, IL12A, IL12B, IL15
18Type I diabetes mellitus2010.3CD28, CD80, GZMB, INS, IL12A, IL12B
19Th17 Differentiation3710.3CD28, CD80, IL12B, IL17A, IL1B, IL21
20Autoimmune thyroid disease2010.3CD28, CD40LG, CD80, GZMB, IL10, IL2
21Th1 Differentiation3710.2CD28, CD80, IL10, IL12A, IL12B, IL18
22IL-6 Pathway3610.2CD80, IL10, IL12A, IL12B, IL18, IL22
23THC Differentiation Pathway3610.2CD28, IL10, IL12A, IL12B, IL18, IL18R1
24Hematopoietic cell lineage2010.1CD36, CD8A, CD14, ITGA4, IL1A, IL1B
25Rheumatoid arthritis2010.0CD28, CD80, MMP3, IL15, IL17A, IL18
26Toxoplasmosis2010.0CIITA, CD40LG, IRGM, IL10, IL12A, IL12B
27PGC1Alpha Pathway3610.0CD80, IL12A, IL12B, IL15, IL18, IL1A
28Allograft rejection2010.0CD28, CD40LG, CD80, GZMB, IL10, IL12A
29Endothelin-1 Signaling Pathway3610.0CD80, IL10, IL12A, IL12B, IL18, IL1A
30Influenza A209.9CIITA, IL12A, IL12B, IL18, IL1A, IL1B
31PEDF Induced Signaling369.8CD80, IL10, IL12A, IL12B, IL15, IL18
32Jak-STAT signaling pathway209.5LEP, IL10, IL12A, IL12B, IL15, IL2
33Tuberculosis209.4VDR, CIITA, CD209, CD14, FCGR2A, FCGR3A
34IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types379.4GZMB, IL12B, IL17A, IL1B, IL21, IL22
35all-trans-Retinoic Acid Signaling in Brain369.4CD80, IL10, IL12A, IL12B, IL15, IL18
36Malaria209.3SELE, CD36, CD40LG, IL10, IL12A, IL18
37Cytokine Network369.2IL10, IL12A, IL12B, IL15, IL18, IL1A
38MIF Mediated Glucocorticoid Regulation369.2CD14, CD80, MIF, IL10, IL12A, IL12B
39MIF Regulation of Innate Immune Cells369.2CD14, CD80, MIF, IL10, IL12A, IL12B
40Measles209.0CD209, CD28, IL12A, IL12B, IL1A, IL1B
41Antioxidant Action of Vitamin-C368.9MYO9B, CD28, CD80, FLNB, IL10, IL12A
42Chagas disease (American trypanosomiasis)208.9CD247, IL10, IL12A, IL12B, IL1B, IL2
43Glucocorticoid Receptor Signaling368.9CD80, GTF2A1, IL10, IL12A, IL12B, IL15
44p38 Signaling368.8CD28, CD80, IL10, IL12A, IL12B, IL15
45Leishmaniasis208.7ITGA4, FCGR2A, FCGR3A, IL10, IL12A, IL12B
46Tec Kinases Signaling368.6CD28, CD80, ITGA4, ITGAE, IL10, IL12A
47TGF-Beta Pathway368.5CD80, IL10, IL12A, IL12B, IL15, IL18
48SOCS Pathway368.4CD80, INS, IL10, IL12A, IL12B, IL15
49Cytokine-cytokine receptor interaction208.2LEP, CD40LG, IL10, IL12A, IL12B, IL15
50JAK-STAT Pathway367.1UBD, CD80, IL10, IL12A, IL12B, IL15

Compounds for genes affiliated with Celiac Disease

Sources:
32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
See all sources

Compounds related to celiac disease according to GeneDecks:

(show top 50)    (show all 421)
idCompoundScoreTop Affiliating Genes
1carbohydrates32 11.0SELE, SELL, CIITA, MUC2, MUC5AC, LCT
2c-peptide32 10.9KCNJ11, SCT, LEP, IL7, CCK, GHRL
3mannose32 10.9CLC, CIITA, CD209, CD79A, CD14, CD80
4cyclophosphamide32 34 9 9 13.9ITGA4, MBL2, TRB@
5h2o232 10.8SELL, SEPP1, BGLAP, PARK7, LEP, MT-CYB
6polyethylene glycol32 10.7SELE, CHKB, LALBA, IFNA2, HP, TSHR
7glutamate32 10.7NAGS, VDR, KCNJ11, SCG5, LEP, MTHFR
8zinc32 18 11.7REL, KIR3DL1, ZFP36L1, SCG5, SCT, CIITA
9ivig32 10.3FCGR3A, IL18R1, FASLG, CCR5, CRP, LTA
10ascorbic acid32 18 11.2VDR, BGLAP, CHKB, MT-CYB, S100B, CD36
11peptidoglycan32 10.2LPP, CIITA, CD14, IL10, IL12B, IL15
12endotoxin32 10.2SELL, CIITA, CHKB, CD14, MIF, IL12B
13acth32 10.1SCG5, SCT, LEP, MLN, MIF, INS
14tuberculin32 10.0CD79A, CD14, CD40LG, MIF, IL10, IL15
15n acetylcysteine32 10.0SELE, MUC5AC, CD79A, MMP12, MMP3, IL18
16cysteine32 9.9REL, SEPP1, VDR, BGLAP, PARK7, SCG5
17con a32 9.8CD28, CD79A, IL10, IL18, IL2, IL21
18poly(i-c)32 9.8IRF1, IL12B, IL15, IL18, IL1B, IL4
19tyrosine32 9.7SH2B3, REG1A, REL, KIR3DL1, KIR2DL5A, SELL
20okt332 9.7SELE, CD79A, CD40LG, IL10, IL15, IL18R1
21rapamycin32 42 10.7SELL, CD80, FOXP3, GZMB, INS, IL18R1
22tgf beta132 9.6CD36, MMP3, FOXP3, IL10, IL15, IL18
23pge232 9.6SELE, SCT, CIITA, MUC5AC, CD14, CD83
24testosterone32 9 18 9 12.6SELE, SEPP1, VDR, BGLAP, PARK7, SCG5
25phosphatidylinositol32 9.5SH2B3, LEP, CIITA, MUC5AC, CD28, CD14
26arginine32 9.4NAGS, VDR, BGLAP, KCNJ11, SCG5, SCT
27epinephrine32 9 18 9 12.4SELE, SELL, SCT, LEP, CHKB, CD79A
28sulfasalazine32 9 9 11.4SELE, MTHFR, CD79A, CD40LG, MMP3, IL12B
29ifn-alpha32 9.4IRF1, IL10, IL17A, IL18, IL2, IL2RA
30fibrinogen32 9.3SELE, SCG5, LEP, CHKB, LALBA, CD79A
31mycophenolate mofetil32 9 9 11.2SELE, CD79A, CD36, CD40LG, IL10, IL18
32alanine32 9.2SELE, SELL, VDR, BGLAP, SCG5, CIITA
33cholesterol32 9 18 9 12.0SELE, SCG5, LEP, CIITA, CHKB, MUC2
34polymyxin b32 8.9SELE, CD14, IL10, IL1A, IL1B, IL1RN
35etanercept32 9 9 10.9LEP, MMP12, MMP3, FCGR2A, FCGR3A, IL10
36neopterin32 8.9CHKB, CD79A, CD14, CD40LG, GZMB, IL10
37infliximab32 9 9 10.7SELE, BGLAP, ITGA4, MMP3, IL10, IL15
38thalidomide32 42 9 9 11.6SELL, CD36, CD40LG, IL10, IL18, IL18R1
39il 1032 8.5VDR, CD8A, IL10, IL12B, IL15, IL18
40thymidine32 18 9.3REG1A, VDR, SCG5, SCT, CIITA, CHKB
41pdtc32 8.1SELE, IRF1, IL18, IL1A, IL1B, IL4
42creatinine32 8.1SELE, SELL, VDR, LEP, MTHFR, MT-CYB
43ly29400232 8.0SELE, LEP, MUC2, GZMB, FCGR2A, IL10
44aspirin32 34 18 10.0SELE, SELL, VDR, CHKB, MTHFR, CD79A
45herbimycin a32 42 8.9SELE, SELL, CD28, CD36, CD14, CD40LG
46simvastatin32 34 42 9 18 9 12.8SELE, SELL, BGLAP, CIITA, CHKB, MMP3
47serine32 7.6REG1A, REL, SELE, SELL, SERPINE2, VDR
48vegf32 7.4SELE, BGLAP, CHKB, S100B, CD36, CD14
49indomethacin32 9 9 9.0SELL, SCT, LEP, CD79A, CD40LG, MMP3
50cycloheximide32 6.4SELE, SELL, SERPINE2, VDR, PARK7, LEP

GO Terms for genes affiliated with Celiac Disease

Sources:
12Gene Ontology
See all sources

Cellular components related to celiac disease according to GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.7TNFSF4, ERBB3, ICOSLG, ICOS, ICAM1, CCR9
2integral to lumenal side of endoplasmic reticulum membraneGO:07155611.4HLA-G, CALR, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA
3ER to Golgi transport vesicle membraneGO:01250711.3HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-G, HLA-DQB1
4MHC class II protein complexGO:04261311.2HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
5clathrin-coated endocytic vesicle membraneGO:03066911.2HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
6trans-Golgi network membraneGO:03258811.1HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
7transport vesicle membraneGO:03065811.1HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
8endocytic vesicle membraneGO:03066611.1HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
9lysosomal membraneGO:00576510.9SLC11A2, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
10MHC class I protein complexGO:04261210.8HFE, HLA-G, HLA-C, HLA-B, HLA-A, MICA
11plasma membraneGO:00588610.4TNF, TNFRSF14, TNFRSF8, TNFSF13B, TNFSF18, TJP1
12membrane raftGO:04512110.2DPP4, TLR4, TNF, FAS, CD226, CD14
13external side of plasma membraneGO:00989710.1TLR2, CTLA4, TNFRSF9, TNFRSF4, TNFRSF14, TNF
14perinuclear region of cytoplasmGO:04847110.0CTLA4, PLA2G4A, NOS2, HFE, TLR4, PRDX5
15cell surfaceGO:0099869.7NOD2, DMD, PTPRK, TNFSF4, TLR2, TGFB1
16cytosolGO:0058298.7NOS2, NOD2, PLEK, PLA2G4A, SNRPB, PPP6C
17extracellular regionGO:0055767.4PRG2, PRL, DEFA5, DEFB103A, DEFB1, TFRC
18extracellular spaceGO:0056156.6TGFB1, CALR, ALB, F2, F3, ICAM1

Biological processes related to celiac disease according to GeneDecks:

(show top 50)    (show all 107)
idNameGO IDScoreTop Affiliating Genes
1T cell costimulationGO:03129511.7DPP4, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1
2immune responseGO:00695511.4RGS1, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2, HLA-DQA1
3interferon-gamma-mediated signaling pathwayGO:06033311.3PTPN2, STAT1, SOCS1, IRF1, CIITA, IRF4
4T cell receptor signaling pathwayGO:05085211.0HLA-DPB1, HLA-DPA1, MAP3K7, CD247, HLA-DQA1, HLA-DQA2
5positive regulation of inflammatory responseGO:05072910.9TGM2, TLR7, IL18, IL12B, IL1RL1, IL15
6positive regulation of interferon-gamma productionGO:03272910.9IL12B, IL12A, IL18, CD40LG, TLR4, LTA
7positive regulation of chemokine productionGO:03272210.8TLR2, TLR4, TNF, IL18, IL6R, TLR7
8cytokine-mediated signaling pathwayGO:01922110.8CIITA, IFNA2, IFNG, ICAM1, HLA-A, HLA-B
9negative regulation of interferon-gamma productionGO:03268910.7HLA-DRB4, HLA-DRB3, TNFSF4, FOXP3, TLR4, IL10
10chemokine-mediated signaling pathwayGO:07009810.7CCR2, CCR1, CCR4, CCRL2, CCL2, CCR5
11T-helper 1 type immune responseGO:04208810.7IL18, IL12B, HLA-DRB3, HLA-DRB4, TLR4, HLA-DRB1
12regulation of immune responseGO:05077610.7ITGA4, CD247, CD226, CD40LG, CD8A, SELL
13innate immune responseGO:04508710.6DEFB103A, DEFB1, DEFA5, IFNA2, TLR8, TLR7
14positive regulation of interleukin-6 productionGO:03275510.5TNFSF4, CD36, TLR7, TLR4, TLR2, IL1B
15positive regulation of interleukin-10 productionGO:03273310.5CD83, CD40LG, IL21, IL4, IL12B, TNFSF4
16positive regulation of NF-kappaB import into nucleusGO:04234610.5IL12B, IL1B, TNF, TLR4, TLR7, TLR2
17positive regulation of osteoclast differentiationGO:04567210.5IL17A, CCL5, CCR1, IL23R, IL12B, IFNG
18positive regulation of interleukin-17 productionGO:03274010.4TGFB1, NOD2, IL23R, IL21, IL18, IL15
19positive regulation of interleukin-12 productionGO:03273510.4TLR4, CD40LG, CD36, IL12B, IL23R, IFNG
20negative regulation of interleukin-17 productionGO:03270010.4IFNG, TNFSF4, TLR4, IL12B, TLR2, IL12A
21defense response to bacteriumGO:04274210.3LALBA, PRG2, IL10, IFNG, NOD2, NOS2
22positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.3IL6, MIF, CD36, IL5, CD80, TLR4
23induction of apoptosisGO:00691710.3TNF, TLR2, TGFB1, LTA, RUNX3, TGM2
24defense response to Gram-positive bacteriumGO:05083010.3TLR2, TNF, MBL2, LTA, IL6, IL12A
25positive regulation of T cell proliferationGO:04210210.3CCL5, IL4, PRKCQ, IFNG, IL15, IL6
26response to heatGO:00940810.2CCL2, CALCA, SOD1, PEBP1, IRF1, CD14
27positive regulation of activated T cell proliferationGO:04210410.2IL2, TNFSF4, ICOSLG, IGF1, IL4, IL23R
28negative regulation of growth of symbiont in hostGO:04413010.2IFNG, CD36, LTA, IL10, MBL2, TNF
29positive regulation of B cell proliferationGO:03089010.2TLR4, TNFRSF4, IL4, IL7, IL5, IL2
30positive regulation of interleukin-2 biosynthetic processGO:04508610.2CD28, CD80, IRF4, IL1A, PRKCQ, IL1B
31cell-cell signalingGO:00726710.0IL22, IL2, IL1B, IL18, IL15, IL10
32lipopolysaccharide-mediated signaling pathwayGO:0316639.9TLR2, TNF, TLR4, TGFB1, STAT1, CCL5
33positive regulation of MHC class II biosynthetic processGO:0453489.8TLR4, IFNG, CIITA, CD40LG, IL10, IL4
34positive regulation of tumor necrosis factor productionGO:0327609.8TLR4, TLR2, IFNG, IL18, IL12B, CD14
35positive regulation of NF-kappaB transcription factor activityGO:0510929.7MAP3K7, TLR4, TLR2, NFKB1, NLRP3, NOD2
36cell surface receptor signaling pathwayGO:0071669.6CCR5, CCL2, CCR1, IFNA2, IL2RA, IL18RAP
37regulation of inflammatory responseGO:0507279.6NLRP1, NOD2, TNFSF4, PTGS2, PARK7, CALCA
38cellular response to lipopolysaccharideGO:0712229.6IL10, NOS2, TNFSF4, TNFAIP3, ICAM1, IFNG
39signal transductionGO:0071659.6MADCAM1, IL1RL2, CCK, IL21, IL4R, CCL2
40positive regulation of mitosisGO:0458409.6CD28, INS, PEBP1, EGF, TNF, IGF1
41response to organic nitrogenGO:0102439.4PEBP1, PLA2G4A, PTGS2, IL1RN, IL1B, TGFB2
42agingGO:0075689.4F3, CALCA, PLA2G4A, TGFB1, PRKCQ, TGFB2
43response to glucocorticoid stimulusGO:0513849.3FAS, IL6, IL1RN, IL1B, IL10, BCKDHB
44response to lipopolysaccharideGO:0324969.2F3, IL1A, IL23R, FASLG, FAS, SELE
45positive regulation of nitric oxide biosynthetic processGO:0454299.2INS, TLR4, TLR2, PTGS2, TNF, ICAM1
46positive regulation of cell proliferationGO:0082849.0ETS1, EPO, FASLG, IL7, IL6R, IL6
47anti-apoptosisGO:0069168.9IL2, IGF1, GPX1, CCL2, FAS, IL1B
48response to hypoxiaGO:0016668.8CRP, CREBBP, TNF, CCL2, FAS, IL1A
49inflammatory responseGO:0069548.3SELE, PARK7, CD14, CD40LG, IRGM, MIF
50response to drugGO:0424938.3LTA, TGFB1, TGFB2, ICAM1, GAD2, GAD1

Molecular functions related to celiac disease according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239511.2HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
2tumor necrosis factor receptor bindingGO:00516410.8STAT1, LTA, TNFSF4, TNFSF18, TNFSF13B, TNFSF13
3chemokine receptor activityGO:00495010.8CCR9, CCR3, CCRL2, CCR1, CCR5, CCR4
4peptide antigen bindingGO:04260510.7CD209, HLA-DRB1, HLA-DRB3, HLA-DRB4, TAP1
5C-C chemokine receptor activityGO:01649310.7CCR9, CCR3, CCR1, CCR5, CCR4, CCR2
6receptor bindingGO:00510210.5TNFSF13, TNFSF13B, TNFSF18, TNFSF4, NOS2, LTA
7transmembrane signaling receptor activityGO:00488810.3KLRB1, KLRD1, TLR2, TLR4, TNFRSF8, ERBB3
8protease bindingGO:0020209.9DPP4, TNFAIP3, TNF, HSPA1B, F3, INS
9cytokine activityGO:0051259.7IL2, IL21, IL22, IL4, IL5, IL6
10hormone activityGO:0051799.6EPO, PRL, TG, PYY, CALCA, IGF1
11protein homodimerization activityGO:0428038.5NFKB1, NOS2, PLEK, CRP, TGFB1, TGFB2
12growth factor activityGO:0080838.3IL7, IGF1, F2, EGF, TGFB1, TGFB2
13protein bindingGO:0055156.5PTPN2, ELMO1, HFE, TSHR, TLR2, TLR4

Sources for Celiac Disease

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS