MCID: CLC005
MIFTS: 69

Celiac Disease

Categories: Genetic diseases, Rare diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Celiac Disease

MalaCards integrated aliases for Celiac Disease:

Name: Celiac Disease 54 38 12 23 50 24 25 29 52 41 42 14 69
Celiac Sprue 12 23 50 24 25
Gluten-Sensitive Enteropathy 23 50 24
Nontropical Sprue 23 50 24
Coeliac Disease 12 50 24
Sprue 25 69
Celiac Disease, Susceptibility to 13
Gluten-Induced Enteropathy 50
Childhood Celiac Disease 69
Idiopathic Steatorrhea 12
Gluten Intolerance 50
Gluten Enteropathy 25
Cœliac Disease 23

Characteristics:

OMIM:

54
Inheritance:
autosomal recessive
multifactorial

Miscellaneous:
genetic heterogeneity
precipitating factors - ingestion of wheat gluten, rye, and/or barley
presentation in infants - impaired growth, diarrhea, abdominal distention, vomiting
presentation in children - diarrhea, constipation (rarely), short stature, pubertal delay, rickets, iron and folate deficiency with anemia
presentation in adults - episodic or nocturnal diarrhea, flatulence, weight loss, iron deficiency anemia, macrocytic anemia, coagulopathy, vitamin d deficiency



GeneReviews:

23
Penetrance The penetrance of celiac disease is low. of individuals with a celiac-associated hla allele genotype, approximately 3% develop celiac disease. see testing strategies, in a symptomatic individual who is on a gluten-free diet, molecular genetic testing and table 3. see genetic counseling for details regarding risk to family members...

Classifications:



Summaries for Celiac Disease

NIH Rare Diseases : 50 celiac disease is an autoimmune disorder that damages the small intestine and inhibits absorption of nutrients. people with celiac disease cannot tolerate gluten, a protein in wheat, rye, barley, and in some products such as medicines, vitamins, and lip balms. when affected people eat food with gluten, or use a product with gluten, the immune system reacts by damaging tiny parts of the lining of the small intestine called villi. because villi normally allow the blood to absorb nutrients from food, affected individuals become malnourished. classic signs and symptoms are caused by inflammation of the gastrointestinal tract and may include diarrhea, weight loss, abdominal pain, swelling, and food intolerance. however, many people have other symptoms involving many body systems, and some people have no symptoms. while celiac disease tends to run in families, it does not follow a specific inheritance pattern. the risk to develop celiac disease is raised by having certain forms of the hla-dqa1 and hla-dqb1 genes. treatment is a lifelong, gluten-free diet. last updated: 2/6/2014

MalaCards based summary : Celiac Disease, also known as celiac sprue, is related to cutaneous t cell lymphoma and lymphoma, and has symptoms including short stature, failure to thrive and ataxia. An important gene associated with Celiac Disease is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are NF-kappaB Signaling and Allograft rejection. The drugs Ethanol and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and thyroid, and related phenotypes are hematopoietic system and endocrine/exocrine gland

MedlinePlus : 41 celiac disease is an immune disease in which people can't eat gluten because it will damage their small intestine. if you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. gluten is a protein found in wheat, rye, and barley. it may also be in other products like vitamins and supplements, hair and skin products, toothpastes, and lip balm. celiac disease affects each person differently. symptoms may occur in the digestive system, or in other parts of the body. one person might have diarrhea and abdominal pain, while another person may be irritable or depressed. irritability is one of the most common symptoms in children. some people have no symptoms. celiac disease is genetic. blood tests can help your doctor diagnose the disease. your doctor may also need to examine a small piece of tissue from your small intestine. treatment is a diet free of gluten. nih: national institute of diabetes and digestive and kidney diseases

Genetics Home Reference : 25 Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.

OMIM : 54
Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy (GSE), is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). Long regarded as gastrointestinal disorder of childhood, the disease is now considered to be a chronic systemic autoimmune disease and is more often diagnosed in adults than in children (Monsuur et al., 2005). For a discussion of genetic heterogeneity of celiac disease, see MAPPING. (212750)

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that is caused by a reaction located in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has symptom abdominal pain, has symptom constipation, has symptom diarrhea, has symptom nausea and vomiting, and has symptom loss of appetite.

Wikipedia : 72 Coeliac disease, also spelled celiac disease, is a long term autoimmune disorder primarily affecting the... more...

GeneReviews: NBK1727

Related Diseases for Celiac Disease

Diseases in the Celiac Disease family:

Celiac Disease 7 Celiac Disease 8
Celiac Disease 3 Celiac Disease 9
Celiac Disease 10 Celiac Disease 11
Celiac Disease 6 Celiac Disease 2
Celiac Disease 12 Celiac Disease 13
Celiac Disease 5 Celiac Disease 4

Diseases related to Celiac Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 342)
id Related Disease Score Top Affiliating Genes
1 cutaneous t cell lymphoma 30.6 CD79A TGM2
2 lymphoma 30.4 CD79A CTLA4 SCHIP1 TG TGM2 TPO
3 hypermobility syndrome 30.4 CTLA4 PTPN22 TPO
4 systemic lupus erythematosus 30.2 CD79A CTLA4 HLA-DQA1 HLA-DQB1 PTPN22
5 rheumatoid arthritis 29.9 CD79A CTLA4 HLA-DQA1 HLA-DQB1 IL15 PTPN22
6 celiac disease 3 12.1
7 celiac disease 4 12.1
8 celiac disease 13 12.1
9 celiac disease 8 12.1
10 celiac disease 6 12.1
11 celiac disease 2 12.1
12 celiac disease 5 12.1
13 celiac disease 12 12.1
14 celiac disease 9 12.1
15 celiac disease 10 12.1
16 celiac disease 7 12.1
17 celiac disease 11 12.1
18 refractory celiac disease 11.9
19 osteomalacia 11.0
20 down syndrome 11.0
21 atypical juvenile parkinsonism 11.0 CTLA4 HLA-DQA1
22 osteogenesis imperfecta congenita, microcephaly, and cataracts 11.0 HLA-DQA1 HLA-DQB1
23 wheat allergy 11.0
24 rickets 11.0
25 collagenous gastritis 11.0
26 breast hemangiopericytoma 11.0 HLA-DQA1 HLA-DQB1
27 biemond syndrome 10.9 HLA-DQA1 HLA-DQB1
28 b cell linker protein deficiency 10.9 CD79A HLA-DQB1 TGM2
29 autoimmune retinopathy 10.9 CTLA4 HLA-DQB1
30 periodic paralysis with later-onset distal motor neuropathy 10.9 HLA-DQB1 IL15 MYO9B
31 pedophilia 10.9 CD79A HLA-DQA1 HLA-DQB1
32 anaerobic meningitis 10.9 CD79A HLA-DQB1 TGM2
33 diffuse cutaneous mastocytosis 10.9 CD79A TGM2
34 right bundle branch block 10.9 CD79A TG
35 hypervitaminosis d 10.8 CD79A HLA-DQA1 HLA-DQB1
36 retinitis pigmentosa 35 10.8 CD79A SH2B3
37 autoimmune disease, multisystem, infantile-onset, 1 10.8
38 clopidogrel resistance 10.8 CTLA4 PTPN22
39 adenohypophysitis 10.8 TG TPO
40 osmotic diarrhea 10.8
41 maxillary sinus adenoid cystic carcinoma 10.8 TG TPO
42 epilepsy with bilateral occipital calcifications 10.8
43 epilepsy occipital calcifications 10.8
44 rhabdomyosarcoma, embryonal, 2 10.8 TG TPO
45 atheroembolism of kidney 10.8 CD79A TG
46 nephrogenic systemic fibrosis 10.8 TG TPO
47 conjunctival deposit 10.7 CTLA4 TG TPO
48 antigen-peptide-transporter 2 deficiency 10.7 CTLA4 PTPN22
49 primary lacrimal atrophy 10.7 CD79A CTLA4
50 cloacogenic carcinoma 10.7 CTLA4 TG TPO

Comorbidity relations with Celiac Disease via Phenotypic Disease Network (PDN):


Chylomicron Retention Disease Deficiency Anemia
Hypothyroidism Iron Deficiency Anemia
Protein-Energy Malnutrition Tropical Sprue

Graphical network of the top 20 diseases related to Celiac Disease:



Diseases related to Celiac Disease

Symptoms & Phenotypes for Celiac Disease

Symptoms via clinical synopsis from OMIM:

54

Growth- Height:
short stature

Neurologic- Central Nervous System:
ataxia
seizures
cerebral calcification

Skin Nails & Hair- Hair:
alopecia

Endocrine Features:
infertility
delayed puberty
autoimmune thyroiditis
type 1 diabetes

Abdomen- Gastroin testinal:
recurrent abdominal pain
steatorrhea
watery diarrhea (children and adults)
small intestine inflammation
flattened villi
more
Neoplasia:
esophageal cancer
intestinal t-cell lymphoma
small bowel cancer
pharyngeal cancer

Hematology:
thrombocytosis
iron deficiency anemia (adults)
macrocytic anemia (folate or rarely b12 deficiency)

Head And Neck- Teeth:
hypoplastic dental enamel

Skeletal:
osteoporosis (70% of patients)

Immunology:
iga deficiency

Growth- Other:
failure to thrive
growth retardation (children)

Neurologic- Peripheral Nervous System:
peripheral neuropathy

Neurologic- Behavioral Psychiatric Manifestations:
depression
anxiety

Laboratory- Abnormalities:
hypocalcemia
elevated liver transaminases
iiga and igg antigliadin antibodies (aga)
iga antiendomysial antibodies (ema)
anti-tissue transglutaminase antibodies (anti-ttg)
more
Growth- Weight:
weight loss

Skeletal- Limbs:
arthralgia

Head And Neck- Mouth:
recurrent aphthous stomatitis

Abdomen- External Features:
abdominal distention (children)

Skin Nails & Hair- Skin:
dermatitis herpetiformis
follicular keratosis


Clinical features from OMIM:

212750

Human phenotypes related to Celiac Disease:

32 (show all 40)
id Description HPO Frequency HPO Source Accession
1 short stature 32 HP:0004322
2 failure to thrive 32 HP:0001508
3 ataxia 32 HP:0001251
4 diarrhea 32 HP:0002014
5 seizures 32 HP:0001250
6 alopecia 32 HP:0001596
7 osteoporosis 32 HP:0000939
8 vomiting 32 HP:0002013
9 depression 32 HP:0000716
10 infertility 32 HP:0000789
11 delayed puberty 32 HP:0000823
12 abdominal pain 32 HP:0002027
13 postnatal growth retardation 32 HP:0008897
14 hypocalcemia 32 HP:0002901
15 lymphoma 32 HP:0002665
16 weight loss 32 HP:0001824
17 polyneuropathy 32 HP:0001271
18 abdominal distention 32 HP:0003270
19 eczema 32 HP:0000964
20 anxiety 32 HP:0000739
21 macrocytic anemia 32 HP:0001972
22 arthralgia 32 HP:0002829
23 rickets 32 HP:0002748
24 steatorrhea 32 HP:0002570
25 thrombocytosis 32 HP:0001894
26 recurrent aphthous stomatitis 32 HP:0011107
27 cerebral calcification 32 HP:0002514
28 iga deficiency 32 HP:0002720
29 folate deficiency 32 HP:0100507
30 vitamin k deficiency 32 HP:0011892
31 vitamin d deficiency 32 HP:0100512
32 prolonged prothrombin time 32 HP:0008151
33 iron deficiency anemia 32 HP:0001891
34 elevated hepatic transaminases 32 HP:0002910
35 celiac disease 32 HP:0002608
36 prolonged partial thromboplastin time 32 HP:0003645
37 type i diabetes mellitus 32 HP:0100651
38 hypoplasia of dental enamel 32 HP:0006297
39 abnormality of the abdominal wall 32 HP:0004298
40 vitamin b12 deficiency 32 occasional (7.5%) HP:0100502

UMLS symptoms related to Celiac Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Celiac Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CD79A CTLA4 HLA-DQA1 HLA-DQB1 IL15 IL18RAP
2 endocrine/exocrine gland MP:0005379 10 CTLA4 HLA-DQA1 HLA-DQB1 IL15 IRF1 PTPN22
3 immune system MP:0005387 9.8 CCR9 CD79A CTLA4 HLA-DQA1 HLA-DQB1 IL15
4 renal/urinary system MP:0005367 9.17 CD79A HLA-DQB1 IRF1 PREP PTPN22 SCHIP1

Drugs & Therapeutics for Celiac Disease

Drugs for Celiac Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 162)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
2
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3 23214-92-8 31703
3
Ethiodized oil Approved Phase 4,Phase 2,Phase 3 8008-53-5
4
Pancrelipase Approved Phase 4,Phase 3,Phase 1,Early Phase 1 53608-75-6
5
Doxil Approved June 1999 Phase 4,Phase 2,Phase 3 31703
6 Anti-Infective Agents Phase 4,Phase 3
7 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1
8 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1
9 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Early Phase 1
10 Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1
11 Hormones Phase 4,Phase 2,Phase 3,Early Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1
13 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
14 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
15 pancreatin Phase 4,Phase 3,Phase 1,Early Phase 1
16 Anti-Infective Agents, Local Phase 4,Phase 3
17 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
18 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
19 Estrogens Phase 4
20 Gentamicins Phase 4
21 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
22
Capecitabine Approved, Investigational Phase 2, Phase 3 154361-50-9 60953
23
Cisplatin Approved Phase 2, Phase 3 15663-27-1 84093 441203 2767
24
Fluorouracil Approved Phase 3 51-21-8 3385
25
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
26
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
27
Simvastatin Approved Phase 2, Phase 3,Phase 1 79902-63-9 54454
28
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
29
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
30
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
31
Levobupivacaine Approved Phase 2, Phase 3 27262-47-1 92253
32
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
33
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
34
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 5310940 9887054 43805 6857599
35 Anti-Inflammatory Agents Phase 2, Phase 3, Early Phase 1
36 Peripheral Nervous System Agents Phase 2, Phase 3, Early Phase 1
37 Antimetabolites Phase 2, Phase 3,Phase 1
38 Immunosuppressive Agents Phase 3
39 Antiemetics Phase 2, Phase 3
40 Autonomic Agents Phase 2, Phase 3
41 glucocorticoids Phase 2, Phase 3
42 Methylprednisolone acetate Phase 2, Phase 3
43 Methylprednisolone Hemisuccinate Phase 2, Phase 3
44 Neuroprotective Agents Phase 2, Phase 3
45 Prednisolone acetate Phase 2, Phase 3
46 Prednisolone hemisuccinate Phase 2, Phase 3
47 Prednisolone phosphate Phase 2, Phase 3
48 Protective Agents Phase 2, Phase 3
49 Anticholesteremic Agents Phase 2, Phase 3,Phase 1
50 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2, Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 262)

id Name Status NCT ID Phase Drugs
1 Prospective Study of Celiac Block Injection: 1 vs. 2 Completed NCT00583479 Phase 4
2 Endoscopic Ultrasound-guided Celiac Plexus Neurolysis (EUS-CPN)With Alcohol in Unresectable Pancreatic Cancer: a Pilot Study Completed NCT00578279 Phase 4 dehydrated alcohol
3 Efficacy and Safety of Drug Eluting Beads TACE in Treatment of HCC in Egyptian Patients Completed NCT03007225 Phase 4 Trans-arterial chemoembolization (TACE);TACE with Drug Eluting Beads procedure
4 Pancreatic Enzyme Supplementation for Celiac Disease Recruiting NCT02475369 Phase 4 pancrelipase
5 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Recruiting NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
6 Prucalopride Prior to Small Bowel Capsule Endoscopy Not yet recruiting NCT02806206 Phase 4 Prucalopride;Placebo
7 Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase Terminated NCT01865695 Phase 4 Creon
8 Randomized Control Trial (RCT) of Transarterial Chemoembolization (TACE) Versus TACE and Oral Drug Therapy in the Treatment of Unresectable Hepatocellular Carcinoma Unknown status NCT00522405 Phase 2, Phase 3
9 The ARTERY FIRST Approach for Resection of Pancreatic Head Cancer Unknown status NCT01332773 Phase 3
10 Effect of Addition of Short Course of Prednisolone to Gluten Free Diet in Naive Celiac Disease Patients Completed NCT01045837 Phase 2, Phase 3 Prednisolone and Gluten free diet
11 Protocol for Correlating Enteropathic Severity and Small Intestinal CYP3A4 Activity in Patients With Celiac Disease Completed NCT01338324 Phase 2, Phase 3 Simvastatin
12 HLA-DQ2-gliadin Tetramer for Diagnosis of Celiac Disease Completed NCT01100099 Phase 2, Phase 3
13 Intraoperative Celiac Plexus Neurolysis for Patients With Operable Pancreatic and Periampullary Cancer Completed NCT00806611 Phase 3
14 Trial of Endoscopic Ultrasound (EUS) - Guided Celiac Plexus Neurolysis Completed NCT00974948 Phase 3
15 Randomized Trial of EUS Neurolysis in Pancreas Cancer Completed NCT00279292 Phase 3
16 Efficacy of EUS-guided Celiac Plexus Blockade in Chronic Pancreatitis Completed NCT00658736 Phase 3 Triamcinolone;Bupivicaine alone
17 Gluten Sensitivity in Non-Celiac Patients Completed NCT01485341 Phase 3
18 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
19 Left Celiac Plexus Resection for Pancreatic Cancer at the Body and Tail Recruiting NCT02117895 Phase 3
20 EUS-guided CGN for Inoperable Cancer Recruiting NCT02356640 Phase 2, Phase 3 Levobupivacaine
21 Resection of the Nerve Plexus on the Right Half of Celiac and SMA Associated With Extended Pancreatoduodenectomy in the Surgical Treatment for Adenocarcinoma of the Head of Pancreas Recruiting NCT02514928 Phase 3
22 Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis Recruiting NCT01318590 Phase 3 Bupivacaine & Triamcinolone Acetonide
23 Comparison of SEEOX and SOX Regimens in Stage ⅢB/ⅢC Gastric Cancer Patients Recruiting NCT02338518 Phase 3 oxaliplatin;etoposide;pharmorubicin;S-1
24 Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation Recruiting NCT02584283 Phase 3 Glutathione
25 Phase III Trial Investigating the Potential Benefit of Adjvant Chemotherapy for Small Bowel Adenocarcinoma Not yet recruiting NCT02502370 Phase 3 observation alone;LV5FU2;FOLFOX
26 A Phase III Study of En Bloc Versus Non-En Bloc Esophagectomy in Esophageal Cancer Terminated NCT00760604 Phase 3
27 Evaluation of the Efficacy and Safety of ALV003 in Symptomatic in Celiac Disease Patients Unknown status NCT01917630 Phase 2 ALV003;placebo
28 Study of Enzyme Supplements to Treat Celiac Disease Unknown status NCT00962182 Phase 1, Phase 2 STAN1;Placebo enzyme;STAN1+gluten
29 Wheat Flour Treatment With Microbial Transglutaminase and Lysine Ethyl Ester: New Frontiers in Celiac Disease Treatment. Unknown status NCT02472119 Phase 2
30 Celiac Plexus Radiosurgery for Pain Management Unknown status NCT02356406 Phase 2
31 Efficacy Study of Acupuncture to Treat the Upper Abdominal Pain of Cancer Patients Unknown status NCT01913574 Phase 2
32 Randomized, Double-Blind, Placebo-Controlled Study of Larazotide Acetate in Subjects With Active Celiac Disease Completed NCT00620451 Phase 2 larazotide acetate;placebo
33 A Double-blind Placebo-controlled Study to Evaluate Larazotide Acetate for the Treatment of Celiac Disease Completed NCT01396213 Phase 2 Larazotide Acetate;placebo
34 A Phase II Study of CCX282-B in Patients With Celiac Disease Completed NCT00540657 Phase 2 CCX282-B;Placebo
35 Safety and Efficacy of ALV003 for the Treatment of Celiac Disease Completed NCT00959114 Phase 2
36 Safety and Efficacy of Varying Methods of ALV003 Administration for the Treatment of Celiac Disease Completed NCT01255696 Phase 2
37 Cytokine Profile in Children With Celiac Disease Completed NCT02244047 Phase 1, Phase 2 Bifidobacterium breve;Placebo (for Bifidobacterium breve)
38 Effect of Aspergillus Niger Prolyl Endoprotease (AN-PEP) Enzyme on the Effects of Gluten Ingestion in Patients With Coeliac Disease Completed NCT00810654 Phase 1, Phase 2
39 Study to Assess the Efficacy of Larazotide Acetate for the Treatment of Celiac Disease Completed NCT00492960 Phase 2 larazotide acetate;placebo
40 Safety and Tolerability Study of Larazotide Acetate in Celiac Disease Subjects Completed NCT00362856 Phase 2 larazotide acetate;Placebo
41 Desensitising Celiac Disease Patients With the Human Hookworm Completed NCT01661933 Phase 1, Phase 2
42 Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity Completed NCT00671138 Phase 2
43 Safety of Prolonged Administration of Triticum Monococcum in Celiac Disease Completed NCT02220166 Phase 2
44 Study of the Efficacy of Larazotide Acetate to Treat Celiac Disease Completed NCT00889473 Phase 2 Larazotide acetate;Placebo
45 Safety and Systemic Exposure Study of BL-7010 in Well-Controlled Celiac Patients. Completed NCT01990885 Phase 1, Phase 2 BL-7010;Placebo
46 FOLFOXIRI as Primary Treatment for Locally Advanced Pancreatic Cancer Completed NCT02351219 Phase 2 FOLFOXIRI
47 Prospective Phase II Trial on Prophylactic Perihepatic Lymphadenectomy in Patients With Colorectal Cancer With Liver Metastasis Completed NCT01565811 Phase 2
48 Cetuximab and Radiation Therapy for Surgically Resectable Esophageal and Gastroesophageal (GE) Junction Carcinomas Completed NCT00319735 Phase 2
49 Bifidobacterium Infantis NLS Super Strain for Celiac Disease Patients on a Gluten-free Diet With Persistent Gastrointestinal Symptoms Recruiting NCT03271138 Phase 2
50 Study of Extensive Clinical Target Volumes in Postoperative Radiotherapy Concurrent With Chemotherapy for Esophageal Squamous Cell Carcinoma Recruiting NCT02916511 Phase 2 Paclitaxel;Carboplatin

Search NIH Clinical Center for Celiac Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Celiac Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Celiac Disease:
Regenerative ColoTherapy
Embryonic/Adult Cultured Cells Related to Celiac Disease:
Adipose-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: celiac disease

Genetic Tests for Celiac Disease

Genetic tests related to Celiac Disease:

id Genetic test Affiliating Genes
1 Celiac Disease 29 24 HLA-DQB1

Anatomical Context for Celiac Disease

MalaCards organs/tissues related to Celiac Disease:

39
Small Intestine, Testes, Thyroid, T Cells, Liver, Bone, Skin

Publications for Celiac Disease

Articles related to Celiac Disease:

(show top 50) (show all 1486)
id Title Authors Year
1
Perspective: Gluten-Free Products for Patients with Celiac Disease Should Not Contain Trace Levels. ( 28507006 )
2017
2
Association of Autoimmune Hepatitis and Celiac Disease: Role of Gluten-Free Diet in Reversing Liver Dysfunction. ( 28491884 )
2017
3
Unusual Onset of Celiac Disease and Addison's Disease in a 12-Year-Old Boy. ( 28758924 )
2017
4
Cardiovascular involvement in celiac disease. ( 28932354 )
2017
5
Thiol/disulphide homeostasis in celiac disease. ( 28533921 )
2017
6
Development of TaqMan probes targeting the four major celiac disease epitopes found in I+-gliadin sequences of spelt (Triticum aestivum ssp. spelta) and bread wheat (Triticum aestivum ssp. aestivum). ( 28912827 )
2017
7
Impact of type 1 diabetes mellitus and celiac disease on nutrition and quality of life. ( 28067892 )
2017
8
Optic neuritis in a patient with celiac disease. ( 28803640 )
2017
9
Whole exome sequencing of a consanguineous family identifies the possible modifying effect of a globally rare AK5 allelic variant in celiac disease development among Saudi patients. ( 28505210 )
2017
10
Efficacy of a point-of-care test based on deamidated gliadin peptides for the detection of celiac disease in pediatric patients. ( 28950706 )
2017
11
Celiac disease prevalence is not increased in patients with functional dyspepsia. ( 28079237 )
2017
12
Salivary Gluten Degradation and Oral Microbial Profiles in Health and Celiac Disease. ( 28087531 )
2017
13
Clinical and biological correlations in celiac disease in children: the prospective single experience of a romanian tertiary center: A case-control study (Strobe-Compliant study). ( 28514313 )
2017
14
The association between semaphorin 3A levels and gluten-free diet in patients with celiac disease. ( 28502679 )
2017
15
New Insights into the Pathogenesis of Celiac Disease. ( 28913337 )
2017
16
A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease. ( 28508029 )
2017
17
Association of PTPN22 Single Nucleotide Polymorphisms with Celiac Disease. ( 28481156 )
2017
18
Celiac Disease and Nonceliac Gluten Sensitivity. ( 28502438 )
2017
19
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease. ( 28878138 )
2017
20
Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study. ( 28465308 )
2017
21
Interleukin-6 and interleukin-17 gene polymorphism association with celiac disease in children. ( 28928101 )
2017
22
TETANY WITH HYPOMAGNESEMIA, HYPOKALEMIA, AND HYPOCALCEMIA AS INITIAL PRESENTATION OF CELIAC DISEASE. ( 28727665 )
2017
23
Retrospective evaluation of pregnant women with celiac disease. ( 28506952 )
2017
24
The Association Between Serological Markers of Celiac Disease and Idiopathic Recurrent Pregnancy Loss. ( 28929834 )
2017
25
Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells. ( 28934294 )
2017
26
Refractory Celiac Disease Successfully Treated With Azathioprine. ( 28725310 )
2017
27
Migraine, Celiac Disease and Intestinal Microbiota. ( 28507424 )
2017
28
Allelic frequencies of the hs1.2 enhancer within the immunoglobulin heavy chain region in Dayton, Ohio patients screened for celiac disease with duodenal biopsy. ( 28473300 )
2017
29
Cross-sectional imaging in refractory celiac disease. ( 28084545 )
2017
30
Genetic predictors of celiac disease, lactose intolerance, and vitamin D function and presence of peptide morphins in urine of children with neurodevelopmental disorders. ( 28738753 )
2017
31
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) mimicking refractory celiac disease. ( 28539227 )
2017
32
Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis. ( 28208589 )
2017
33
Potential role of the IL-33/ST2 axis in celiac disease. ( 26343805 )
2017
34
Celiac disease-related osteopathy among Saudi celiac patients: Are we adherent to recommendations? ( 28937024 )
2017
35
Microwave-based treatments of wheat kernels do not abolish gluten epitopes implicated in celiac disease. ( 28088490 )
2017
36
Open-Capsule Budesonide for Refractory Celiac Disease. ( 28323276 )
2017
37
Nutritional Nightmare: Hypoparathyroidism Secondary to Celiac Disease. ( 28826689 )
2017
38
No Need for Routine Endoscopy in Children With Celiac Disease on a Gluten-free diet. ( 28489675 )
2017
39
Screening for Celiac Disease: Recommendation Statement. ( 28925634 )
2017
40
Celiac Disease Symptom Resolution: Effectiveness of the Gluten Free Diet. ( 28514243 )
2017
41
Iron Status in Pediatric Celiac Disease: A Retrospective Chart Review. ( 28953524 )
2017
42
Primary care physicians are under-testing for celiac disease in patients with iron deficiency anemia: Results of a national survey. ( 28931034 )
2017
43
Borrelia infection and risk of celiac disease. ( 28911326 )
2017
44
The eyes of children with celiac disease. ( 28087348 )
2017
45
Gluten-free diet is not recommended for people without celiac disease. ( 28468759 )
2017
46
Comprehensive Computational Analysis of GWAS Loci Identifies CCR2 as a Candidate gene for Celiac Disease Pathogenesis. ( 28059456 )
2017
47
Cortical involvement in celiac disease before and after long-term gluten-free diet: A Transcranial Magnetic Stimulation study. ( 28489931 )
2017
48
Tissue Transglutaminase Levels Are Not Sufficient to Diagnose Celiac Disease in North America Without Intestinal Biopsies: Don't Throw the Baby Out with the Bathwater. ( 28916977 )
2017
49
Trichotillomania in celiac disease patient refractory to iron replacement. ( 28779566 )
2017
50
The Effect of Gluten Free Diet on Clinical Symptoms and the Intestinal Mucosa of Patients With Potential Celiac Disease. ( 28922261 )
2017

Variations for Celiac Disease

Expression for Celiac Disease

Search GEO for disease gene expression data for Celiac Disease.

Pathways for Celiac Disease

GO Terms for Celiac Disease

Cellular components related to Celiac Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 CCR9 CD79A CTLA4 HLA-DQA1 IL15 KLRK1
2 MHC class II protein complex GO:0042613 8.62 HLA-DQA1 HLA-DQB1

Biological processes related to Celiac Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.63 CCR9 CTLA4 HLA-DQA1 HLA-DQB1 IL15 IL18RAP
2 interferon-gamma-mediated signaling pathway GO:0060333 9.5 HLA-DQA1 HLA-DQB1 IRF1
3 embryonic hemopoiesis GO:0035162 9.46 SH2B3 TPO
4 regulation of innate immune response GO:0045088 9.43 IRF1 PTPN22
5 immune system process GO:0002376 9.43 CD79A CTLA4 HLA-DQA1 IRF1 KLRK1 PTPN22
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.4 HLA-DQA1 HLA-DQB1
7 hormone biosynthetic process GO:0042446 9.37 TG TPO
8 negative regulation of regulatory T cell differentiation GO:0045590 9.26 CTLA4 IRF1
9 T cell costimulation GO:0031295 8.92 CTLA4 HLA-DQA1 HLA-DQB1 KLRK1
10 signal transduction GO:0007165 10.08 CCR9 IL15 IL18RAP KLRK1 MYO9B SH2B3

Molecular functions related to Celiac Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.62 HLA-DQA1 HLA-DQB1

Sources for Celiac Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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