Celiac Disease malady
Categories: Genetic diseases, Rare diseases, Gastrointestinal diseases, Immune diseases
11Disease Ontology, 12diseasecard, 13DISEASES, 23GeneReviews, 24GeneTests, 25Genetics Home Reference, 26GTR, 29ICD10, 31ICD9CM, 34LifeMap Discovery®, 37MedlinePlus, 38MeSH, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS
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Aliases & Descriptions for Celiac Disease:
Penetrance: the penetrance of celiac disease is low. of individuals with a celiac-associated hla allele genotype, approximately 3% develop celiac disease. see testing strategies, in a symptomatic individual who is on a gluten-free diet, molecular genetic testing and table 3. see genetic counseling for details regarding risk to family members...
Global: Genetic diseases, Rare diseases
Anatomical: Gastrointestinal diseases, Immune diseases
NIH Rare Diseases:47 Celiac disease is an autoimmune disorder that damages the small intestine and inhibits absorption of nutrients. People with celiac disease cannot tolerate gluten, a protein in wheat, rye, barley, and in some products such as medicines, vitamins, and lip balms. When affected people eat food with gluten, or use a product with gluten, the immune system reacts by damaging tiny parts of the lining of the small intestine called villi. Because villi normally allow the blood to absorb nutrients from food, affected individuals become malnourished. Classic signs and symptoms are caused by inflammation of the gastrointestinal tract and may include diarrhea, weight loss, abdominal pain, swelling, and food intolerance. However, many people have other symptoms involving many body systems, and some people have no symptoms. While celiac disease tends to run in families, it does not follow a specific inheritance pattern. The risk to develop celiac disease is raised by having certain forms of the HLA-DQA1 and HLA-DQB1 genes. Treatment is a lifelong, gluten-free diet. Last updated: 2/6/2014
MalaCards based summary: Celiac Disease, also known as celiac sprue, is related to cutaneous t cell lymphoma and systemic lupus erythematosus, and has symptoms including vitamin b12 deficiency, depression and anxiety. An important gene associated with Celiac Disease is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways are Thyroxine (Thyroid Hormone) Production and CTLA4 Signaling. The drug medium chain triglycerides has been mentioned in the context of this disorder. Affiliated tissues include small intestine to gliadin, small intestine and testes, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.
Disease Ontology:11 An autoimmune disease of gastrointestinal tract that is caused by a reaction located in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has symptom abdominal pain, has symptom constipation, has symptom diarrhea, has symptom nausea and vomiting, and has symptom loss of appetite.
Genetics Home Reference:25 Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.
OMIM:51 Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy (GSE), is a multifactorial disorder of the... (212750) more...
MedlinePlus:37 Celiac disease is an immune disease in which people can't eat gluten because it will damage their small intestine. if you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. gluten is a protein found in wheat, rye, and barley. it is found mainly in foods but may also be in other products like medicines, vitamins and supplements, lip balm, and even the glue on stamps and envelopes. celiac disease affects each person differently. symptoms may occur in the digestive system, or in other parts of the body. one person might have diarrhea and abdominal pain, while another person may be irritable or depressed. irritability is one of the most common symptoms in children. some people have no symptoms. celiac disease is genetic. blood tests can help your doctor diagnose the disease. your doctor may also need to examine a small piece of tissue from your small intestine. treatment is a diet free of gluten. nih: national institute of diabetes and digestive and kidney diseases
Wikipedia:70 Coeliac disease, also spelled celiac disease, is an autoimmune disorder affecting primarily the small... more...
GeneReviews for NBK1727
Symptoms by clinical synopsis from OMIM:212750
Clinical features from OMIM:212750
Symptoms:11 (show all 5)
Human phenotypes related to Celiac Disease:63 (show all 40)
UMLS symptoms related to Celiac Disease:gastrointestinal gas, sucrose intolerance, fat intolerance, nausea and vomiting, heartburn, dyspepsia, diarrhea, constipation, abdominal pain
Drugs for Celiac Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 152)
Interventional clinical trials:(show top 50) (show all 230)
Search NIH Clinical Center for Celiac Disease
Inferred drug relations via UMLS67/NDF-RT45:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Celiac Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Celiac Disease:
Embryonic/Adult Cultured Cells Related to Celiac Disease:
MalaCards organs/tissues related to Celiac Disease:35
Small intestine, Testes, Thyroid, T cells, Liver, Bone, Kidney
FMA organs/tissues related to Celiac Disease:17
Small intestine to gliadin
MGI Mouse Phenotypes related to Celiac Disease:40
Articles related to Celiac Disease:(show top 50) (show all 1423)
Search GEO for disease gene expression data for Celiac Disease.
Pathways related to Celiac Disease according to GeneCards Suite gene sharing:
Cellular components related to Celiac Disease according to GeneCards Suite gene sharing:
Biological processes related to Celiac Disease according to GeneCards Suite gene sharing:(show all 8)
Molecular functions related to Celiac Disease according to GeneCards Suite gene sharing:
30ICD10 via Orphanet
39MESH via Orphanet
52OMIM via Orphanet
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
68UMLS via Orphanet