Celiac Disease malady

MedlinePlus: If you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. gluten is a protein in wheat, rye and barley. it is found mainly in foods but may also be in other products like medicines, vitamins and even the glue on stamps and envelopes. celiac disease affects each person differently. symptoms may occur in the digestive system, or in other parts of the body. one person might have diarrhea and abdominal pain, while another person may be irritable or depressed. irritability is one of the most common symptoms in children. some people have no symptoms. celiac disease is genetic. blood tests can help your doctor diagnose the disease. your doctor may also need to examine a small piece of tissue from your small intestine. treatment is a diet free of gluten. nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Celiac Disease, also known as coeliac disease, is related to type 1 diabetes mellitus and autoimmune thyroiditis, and has symptoms including nausea, loss of appetite and abdominal pain. An important gene associated with Celiac Disease is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Immune System and Antigen processing and presentation. The drug mct and the compounds calcium and aspartate have been mentioned in the context of this disorder. Affiliated tissues include small intestine to gliadin, liver and kidney, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology: A food allergy that is caused by a reaction located in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe triticeae. the disease is associated with hla-dq gene. it has symptom abdominal pain, has symptom constipation, has symptom diarrhea, has symptom nausea and vomiting, and has symptom loss of appetite.⁶

Genetics Home Reference: Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.¹⁷

Wikipedia: Coeliac disease (pron.: /ˈsiːli.æk/; spelled celiac disease in North America and often celiac sprue)...⁴⁴ more...

OMIM: 212750

GeneReviews summary for celiac

Aliases & Descriptions:

celiac disease 6 7 44 15 17 8 33 32 23 43 coeliac disease 6 15 16 celiac sprue 6 15 16 gluten-sensitive enteropathy 15 16 celiac disease (disorder) 6 16 nontropical sprue 15 16

celiac disease nos (disorder) 6 steatorrhoea - idiopathic 6 idiopathic steatorrhea 6 gluten enteropathy 17 steatorrhea 43 sprue 17

Disease types for celiac disease family:

celiac disease 4	celiac disease 10
celiac disease 13	celiac disease 6
celiac disease 7	celiac disease 9
celiac disease 11	celiac disease 12
celiac disease 2	celiac disease 5
celiac disease 8	celiac disease 3

Diseases related to celiac disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1002)

id	Related Disease	Score	Top Affiliating Genes
1	type 1 diabetes mellitus	33.7	KIR3DL1, VDR, BGLAP, SCT, LEP, CIITA
2	autoimmune thyroiditis	32.8	CIITA, CHKB, CD80, IL12B, IL2RA, IL4
3	hemochromatosis	32.2	MT-CYB, CALR, HP, HLA-B, HEPH, HFE
4	dermatitis herpetiformis	31.4	SELE, MYO9B, CD79A, CD40LG, MMP12, MMP3
5	primary biliary cirrhosis	31.2	SELL, VDR, BGLAP, SCT, CIITA, CD79A
6	giardiasis	30.7	SCT, LCT, CD79A, GZMB, ENO1, TGFB1
7	eosinophilic esophagitis	30.5	MUC5AC, IL10, IL5, CCR3, IFNG, HLA-DQA1
8	crohn's disease	30.2	MUC2, CD80, FOXP3, MLN, IRF1, MIF
9	turner syndrome	30.1	BGLAP, IGF1, TPO, DMD, CYP21A2, TG
10	hodgkin's lymphoma	30.0	REL, CD28, CD80, CD247, ITGA4, GZMB
11	collagenous colitis	29.7	CD79A, CD40LG, NOD2, NOS2, RNASE3, TG
12	psoriatic arthritis	29.6	IL10, IL1B, IL1RN, IL6, TNF, NOD2
13	non-hodgkin lymphoma	29.6	SELL, VDR, BACH2, CD28, CD14, CD80
14	immunodeficiency	29.5	KIR3DL1, SELL, CIITA, CD209, CD28, CD79A
15	hepatitis	29.5	GZMB, GSR, FASLG, FAS, GPT, IFNA2
16	multiple sclerosis	29.4	ZMIZ1, CLEC16A, UBD, CD14, CD226, MICB
17	ulcerative colitis	29.2	SELE, SELL, BGLAP, CHKB, MUC2, CD28
18	addison's disease	29.2	VDR, CLEC16A, BGLAP, CD79A, CD226, FOXP3
19	arthritis	29.2	SELL, MMP3, IL17A, IL1A, IL1B, IL6
20	eosinophilic gastroenteritis	29.2	IL5, ALB, RNASE3, PRG2, CSN1S1
21	iron deficiency anemia	29.1	GSR, ALB, GHRL, TNF, HEPH, HFE
22	pure red-cell aplasia	29.1	CD79A, CD40LG, GZMB, IL2, IL2RA, F2
23	rheumatoid arthritis	29.0	IL1RN, MBL2, HLA-DRB1, CRP, LTA
24	inflammatory bowel disease	28.8	SELE, SELL, VDR, MYO9B, BGLAP, SCT
25	short stature	28.6	VDR, BGLAP, PARK7, LEP, CD36, FLNB
26	diabetes mellitus	28.5	SH2B3, REG1A, KIR3DL1, SELE, SELL, VDR
27	gastroenteritis	28.4	LCT, CD79A, MLN, IL10, IL1B, IL1RN
28	diarrhea	28.4	KCNJ11, SCT, LCT, CD79A, CD14, CD40LG
29	schizophrenia	28.2	MTHFR, MICB, IL1B, IL1RN, IL2, IL4
30	rickets	28.1	VDR, BGLAP, CD36, IGF1, ALB, CALCA
31	short bowel syndrome	27.8	LEP, CD79A, IL1B, CCK, IGF1, F3
32	hyperhomocysteinemia	27.8	SELE, MTHFR, INS, GSR, IL18, IL1B
33	systemic lupus erythematosus	27.8	SELE, CIITA, CD28, CD79A, CD40LG, CD80
34	alopecia areata	27.6	VDR, CIITA, CD79A, GZMB, MICA, MIF
35	duodenitis	27.5	VDR, SCG5, SCT, LEP, MUC2, MUC5AC
36	thyroiditis	27.2	SELE, SEPP1, VDR, CLEC16A, BGLAP, PARK7
37	cholangitis	27.2	REL, KIR3DL1, SCT, MUC2, ATG16L1, CD28
38	thrombocytosis	27.1	MTHFR, CD79A, CD40LG, IL1A, IL1B, IL4
39	irritable bowel syndrome	27.0	LEP, LCT, CD79A, CD40LG, MLN, IL10
40	hepatitis c	27.0	CIITA, CD28, CD40LG, IRF1, GSR, IL10
41	common variable immunodeficiency	26.9	SELL, BGLAP, CD28, CD79A, CD36, CD40LG
42	spontaneous abortion	26.4	KIR3DL1, KIR2DL5A, MTHFR, CD40LG, FOXP3, GSR
43	alopecia	26.4	LPP, VDR, CIITA, CD79A, GZMB, MICA
44	down syndrome	25.7	REG1A, LEP, MTHFR, S100B, CD79A, CD36
45	dermatitis	25.4	REL, SELE, SELL, MYO9B, BGLAP, LEP
46	twinning	25.1	VDR, BGLAP, LEP, MTHFR, MT-CYB, CD79A
47	psoriasis	24.7	KIR3DL1, KIR2DL5A, SELE, VDR, BGLAP, LEP
48	infertility	24.6	SEPP1, PARK7, LEP, MTHFR, CD79A, FOXP3
49	anemia	24.2	SELE, SELL, VDR, SCT, LEP, CHKB
50	lupus erythematosus	24.0	SH2B3, REL, KIR3DL1, KIR2DL5A, SELE, SELL

Clinical features from OMIM: 212750
Symptoms: nausea, loss of appetite, abdominal pain, constipation, diarrhea.⁶

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 mct

Genetic tests related to celiac disease:

id	Genetic test	Affiliating Genes
1	Celiac Disease clinical/research	HLA-DQA1, HLA-DQB1

MalaCards organs/tissues related to celiac disease:

²²

FMA organs/tissues related to celiac disease:

¹¹

MGI Mouse Phenotypes related to celiac disease:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	12.4	SH2B3, MYO9B, ZMIZ1, ZFP36L1, UBASH3A, BACH2
2	immune system phenotype	MP:0005387	11.1	REL, SELL, SERPINE2, VDR, MYO9B, ZFP36L1
3	respiratory system phenotype	MP:0005388	10.3	REL, SELL, PBX3, SCG5, CD14, IL12A
4	renal/urinary system phenotype	MP:0005367	10.2	SCHIP1, INS, CCR1, TNFAIP3, DMD, PLA2G4A
5	endocrine/exocrine gland phenotype	MP:0005379	10.2	REG1A, SELL, SERPINE2, KCNJ11, SCG5, SCHIP1
6	no phenotypic analysis	MP:0003012	9.6	SERPINE2, KCNJ11, MTHFR, CD209, CD79A, FOXP3
7	mortality/aging	MP:0010768	9.5	REL, SELE, SEPP1, NAGS, LPP, VDR
8	liver/biliary system phenotype	MP:0005370	9.4	REL, SEPP1, SCG5, ATXN2, CD36, INS
9	nervous system phenotype	MP:0003631	9.4	REL, SERPINE2, ZFP36L1, PBX3, KCNJ11, SCG5
10	integument phenotype	MP:0010771	9.3	REL, NAGS, ZMIZ1, PBX3, KCNJ11, SCG5
11	growth/size phenotype	MP:0005378	9.2	REL, SELE, SEPP1, NAGS, VDR, ZMIZ1
12	digestive/alimentary phenotype	MP:0005381	8.7	REL, VDR, PBX3, SCHIP1, LEP, MUC2
13	skeleton phenotype	MP:0005390	8.1	REL, VDR, PBX3, SCHIP1, LEP, MTHFR
14	reproductive system phenotype	MP:0005389	8.0	REG1A, SERPINE2, SEPP1, VDR, SCHIP1, LEP
15	adipose tissue phenotype	MP:0005375	7.8	KCNJ11, SCG5, LEP, ATXN2, CD36, CD14
16	behavior/neurological phenotype	MP:0005386	7.7	SELE, SERPINE2, SEPP1, NAGS, PBX3, PARK7
17	normal phenotype	MP:0002873	7.6	SELE, MYO9B, CIITA, UBASH3A, LALBA, S100B
18	tumorigenesis	MP:0002006	7.4	SELL, ZFP36L1, LEP, MUC2, CD226, GZMB
19	homeostasis/metabolism phenotype	MP:0005376	6.8	REG1A, REL, SELE, SELL, SERPINE2, SEPP1
20	cellular phenotype	MP:0005384	6.8	SH2B3, REL, SELE, SELL, SERPINE2, SEPP1
21	muscle phenotype	MP:0005369	6.5	ZFP36L1, KCNJ11, SCHIP1, LEP, CHKB, CD36
22	vision/eye phenotype	MP:0005391	5.6	SELE, LEP, MTHFR, CD36, FOXP3, INS
23	cardiovascular system phenotype	MP:0005385	5.5	REL, SELE, SELL, VDR, ZMIZ1, ZFP36L1

Articles related to celiac disease:

(show top 50)    (show all 397)

id	Title	Authors	Year	Affiliating Genes
1	The missense variation Q705K in CIAS1/NALP3/NLRP3 gen e and an NLRP1 haplotype are associated with celiac disease. (21245836)	Pontillo A.... Crovella S.	2011	NLRP3, NLRP1
2	Transglutaminase 2 dysfunctions in the development of autoimmune disorders: celiac disease and TG2-/- mouse. (22220477)	Szondy Z.... FAcsA1s L.	2011	TGM2
3	Defensin-mRNA expression in the upper gastrointestina l tract is modulated in children with celiac disease and Helicobacter pylori-po sitive gastritis. (20400909)	VordenbAoumen S.... Schmidt-Choudhury A.	2010	DEFB1, DEFA5
4	Screening detects a high proportion of celiac disease in young HLA-genotyped children. (19915493)	BjAPrck S.... Agardh D.	2010	HLA-DQB1
5	Dynamics of celiac disease-specific serology after in itiation of a gluten-free diet and use in the assessment of compliance with tre atment. (19679520)	Sugai E.... Bai J.C.	2010	CD79A
6	PPAR signaling pathway and cancer-related proteins ar e involved in celiac disease-associated tissue damage. (20454521)	Simula M.P.... De Re V.	2010	PRDX4, PEBP1
7	Selenium status and over-expression of interleukin-15 in celiac disease and autoimmune thyroid diseases. (21169670)	Stazi A.V.... Trinti B.	2010	IL15
8	Cystic fibrosis is a risk factor for celiac disease. (20300660)	Walkowiak J.... Szaflarska-PopA8awska A.	2010	HLA-DQB1
9	Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease. (20153259)	Harris K.M.... Mann D.L.	2010	IL15
10	The IL6-174G/C polymorphism is associated with celiac disease susceptibility in girls. (19280716)	Dema B.... NA_A+ez C.	2009	IL6, IL6R
11	Antioxidant status and lipid peroxidation in small in testinal mucosa of children with celiac disease. (19560448)	StojiljkoviA8 V.... PajoviA8 S.B.	2009	SOD1, GSR, GPX1
12	Newly identified genetic risk variants for celiac disease related to the immune response. (18311140)	Hunt K.A.... van Heel D.A.	2008	IL2, CCR3, CCR1
13	CTLA-4 gene polymorphisms predispose to autoimmune endocrinopathies but not to celiac disease. (18580850)	Dallos T.... Kovacs L.	2008	CTLA4
14	Increased prevalence of celiac disease without gastrointestinal symptoms in adults MICA 5.1 homozygous subjects from the Campania area. (18282752)	Tinto N.... Sacchetti L.	2008	HLA-DQA1, HLA-A, HLA-DQB1
15	Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits. (18312620)	Stenman S.M.... Kaukinen K.	2008	TGM2
16	A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease. (17629515)	Henderson K.N.... Anderson R.P.	2007	HLA-DQA1, HLA-DQB1, ENSG00000233209
17	Determining IgA and IgG antigliadin, IgA antitransglutaminase, and antiendomysial antibodies in monkey esophagus and in umbilical cord for diagnosis of celiac disease in developing countries. (18030232)	Bahia M.... Andrade E.M.	2007	CD79A
18	Celiac disease--sandwiched between innate and adaptive immunity. (16728270)	Stepniak D.... Koning F.	2006	IL15
19	MHC class I chain-related gene B promoter polymorphisms and celiac disease. (16698444)	Rodriguez-Rodero S.... Lopez-Larrea C.	2006	MICB
20	Celiac disease. (16722573)	Holtmeier W.... Caspary W.F.	2006	TGM2
21	Prevalence of autoantibodies associated with thyroid and celiac disease in Ullrich-Turner syndrome in relation to adult height after growth hormone treatment. (16562588)	Bettendorf M.... Ranke M.B.	2006	TPO, TG
22	Islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes from Sri Lanka. (17259793)	Premawardhana L.D.... Rees Smith B.	2006	TPO, CYP21A2, TG
23	Clinical picture of celiac disease in children (15859547)	Grzybowska-Chlebowczyk U.... GoA8ka D.	2005	CD79A
24	Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease. (16143118)	Matysiak-Budnik T.... Heyman M.	2005	PREP
25	Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. (16282976)	Monsuur A.J.... Wijmenga C.	2005	MYO9B
26	Relationship of HLA-DQ8 and severity of celiac disease: comparison of New York and Parisian cohorts. (15476152)	Johnson T.C.... Green P.H.	2004	HLA-DQA1, HLA-DQB1
27	Pathomechanisms in celiac disease. (14600421)	Dieterich W.... Schuppan D.	2003	PREP
28	HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. (12651074)	Karell K.... Partanen J.	2003	HLA-DQA1, HLA-DQB1, HLA-DRB1
29	Celiac disease and autoimmune diseases or systemic disease. Six cases and a review of the literature (14593308)	Delbrel X.... Longy-Boursier M.	2003	INS
30	Serum soluble interleukin-2 receptor, interleukin-6, and tumor necrosis factor-alpha levels in children with celiac disease: response to treatment. (12394376)	Romaldini C.C.... CanAsado E.L.	2002	IL2RA
31	Antibodies to human tissue transglutaminase for the diagnosis of celiac disease. (11593137)	Vitoria J.C.... Ayesta A.	2001	TGM2
32	Vitamin B12 deficiency in untreated celiac disease. (11280545)	Dahele A.... Ghosh S.	2001	CD79A
33	Genome-wide linkage analysis of Scandinavian affected sib-pairs supports presence of susceptibility loci for celiac disease on chromosomes 5 and 11. (11840196)	Naluai A.T.... Wahlstrom J.	2001	CELIAC2
34	Celiac disease in a patient with a congenital deficiency of intestinal enteropeptidase. (11467662)	Moroz S.P.... Haworth J.C.	2001	TMPRSS15
35	Celiac disease and TNF promoter polymorphisms. (10773355)	de la Concha E.G.... Figueredo M.A.	2000	TNF
36	Study of two ectopeptidases in the susceptibility to celiac disease: two newly identified polymorphisms of dipeptidylpeptidase IV. (10776965)	Clot F.... Fulchignoni-Lataud M.C.	2000	DPP4
37	Human leukocyte antigen class II alleles in white Brazilian patients with celiac disease. (11045836)	Silva E.M.... Donadi E.A.	2000	HLA-DQB1, HLA-DRB1
38	Gastric metaplasia: a frequently overlooked feature of duodenal biopsy specimens in untreated celiac disease. (10776950)	Shaoul R.... Forstner G.	2000	TFF1, MUC5AC
39	Celiac disease diagnosis in misdiagnosed children. (11044476)	Picarelli A.... Anania M.C.	2000	CD79A
40	Human genome search in celiac disease using gliadin cDNA as probe. (10903861)	Kumar R.... Laurie G.W.	2000	GABRA4
41	Interleukin 15 mediates epithelial changes in celiac disease. (11040186)	Maiuri L.... Londei M.	2000	FAS, TFRC, IL15
42	Antibodies to human recombinant tissue transglutamina se measured by radioligand assay: evidence for high diagnostic sensitivity for celiac disease. (10437627)	Seissler J.... Scherbaum W.A.	1999	CD79A
43	IgA antibodies to tissue transglutaminase: An effective diagnostic test for celiac disease. (9931524)	Troncone R.... Sacchetti L.	1999	CD79A
44	Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. (9721152)	Nilsen E.M.... Brandtzaeg P.	1998	IL2, IL4, IL5
45	Is small bowel biopsy necessary in adults with suspected celiac disease and IgA anti-endomysium antibodies? 100% positive predictive value for celiac disease in adults. (8565771)	Valdimarsson T.... StrAPm M.	1996	CD79A
46	Prevalence and diagnosis of celiac disease in IgA-deficient children. (8885812)	Meini A.... Plebani A.	1996	CD79A
47	Polymorphism of antigen processing (TAP, LMP) and HLA class II genes in celiac disease. (8045794)	Djilali-Saiah I.... Bach J.F.	1994	FLNB
48	Insulin-like growth factor-I in celiac disease. (7876991)	Weile B.... Skakkebaek N.E.	1994	IGF1
49	HLA-linked heat-shock protein 70 (HSP70-2) gene polymorphism and celiac disease. (8096093)	Partanen J.... Koskimies S.	1993	HSPA1B, C6orf48
50	Serological markers and celiac disease: a new diagnostic approach? (2193137)	Calabuig M.... FarrAc C.	1990	CD79A

Genes related to celiac disease according to GeneCards:

(show top 50)    (show all 290)

id	Symbol	Description	Score	GeneCards Section Context
1	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.1	Functions, Summaries, Aliases & Descriptions, Publications
2	MYO9B	myosin IXB	11.1	Summaries, Publications
3	CELIAC7	Celiac disease, susceptibility to, 7	11.1	Aliases & Descriptions
4	CELIAC12	Celiac disease, susceptibility to, 12	11.1	Aliases & Descriptions
5	CELIAC8	Celiac disease, susceptibility to, 8	11.1	Aliases & Descriptions
6	CELIAC11	Celiac disease, susceptibility to, 11	11.1	Aliases & Descriptions
7	CELIAC10	Celiac disease, susceptibility to, 10	11.1	Aliases & Descriptions
8	CELIAC13	Celiac disease, susceptibility to, 13	11.1	Aliases & Descriptions
9	CELIAC9	Celiac disease, susceptibility to, 9	11.1	Aliases & Descriptions
10	CELIAC5	Celiac disease, susceptibility to, 5	11.1	Aliases & Descriptions
11	CELIAC6	Celiac disease, susceptibility to, 6	11.1	Aliases & Descriptions
12	CELIAC2	celiac disease 2	11.1	Publications, Aliases & Descriptions
13	TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.1	Publications, Summaries
14	SH2B3	SH2B adaptor protein 3	11.1	Summaries, Publications
15	KIAA1109	KIAA1109	11.1	Publications, Summaries, UniProt Related
16	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Summaries
17	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Summaries
18	IDDM12	insulin-dependent diabetes mellitus 12	11.0
19	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications, UniProt Related
20	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
21	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
22	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
23	SPINK4	serine peptidase inhibitor, Kazal type 4	11.0	Publications
24	SPINK2	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)	11.0	Publications
25	IL15	interleukin 15	11.0	Publications
26	SPINK1	serine peptidase inhibitor, Kazal type 1	11.0	Publications
27	MICB	MHC class I polypeptide-related sequence B	11.0	Publications
28	PREP	prolyl endopeptidase	11.0	Publications
29	CCR9	chemokine (C-C motif) receptor 9	11.0	Publications
30	LALBA	lactalbumin, alpha-	11.0	Publications
31	IRF1	interferon regulatory factor 1	11.0	Publications
32	SPINK5	serine peptidase inhibitor, Kazal type 5	11.0	Publications
33	KLRK1	killer cell lectin-like receptor subfamily K, member 1	11.0	Publications
34	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	11.0	Publications
35	TPO	thyroid peroxidase	11.0	Publications
36	MMP12	matrix metallopeptidase 12 (macrophage elastase)	11.0	Publications
37	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
38	TFRC	transferrin receptor (p90, CD71)	11.0	Publications
39	TJP1	tight junction protein 1	11.0	Publications
40	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications
41	CALR	calreticulin	11.0	Publications
42	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications
43	CSN1S1	casein alpha s1	11.0	Publications
44	DPP4	dipeptidyl-peptidase 4	11.0	Publications
45	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
46	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
47	HLA-G	major histocompatibility complex, class I, G	11.0	Publications
48	PYY	peptide YY	11.0	Publications
49	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
50	CLEC16A	C-type lectin domain family 16, member A	11.0	Publications

Pathways related to celiac disease according to GeneDecks:

(show top 50)    (show all 140)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	11.8	REL, KIR3DL1, CIITA, S100B, CD79A, CD226
2	Antigen processing and presentation20	11.8	KIR3DL1, KIR2DL5A, CIITA, CD8A, HSPA1B, HLA-C
3	Phagosome20	11.6	CD209, CD36, CD14, FCGR2A, FCGR3A, MBL2
4	CTL Mediated Apoptosis36	11.4	GZMB, HLA-A, HLA-B, HLA-C, HLA-DMB, HLA-DPA1
5	Cell adhesion molecules (CAMs)20	11.3	SELL, CD28, CD8A, CD80, CD226, ITGA4
6	Immune response_IL-22 signaling pathway41	11.3	CD28, IL12A, IL12B, IL2, IL22, IL2RA
7	Immune response IL-22 signaling pathway10	11.3	CD28, IL12A, IL12B, IL2, IL22, IL2RA
8	Immune response_ICOS pathway in T-helper cell41	11.2	REL, ICOSLG, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA2
9	RAR-Gamma-RXR-Alpha Degradation36	11.2	UBD, CD80, GTF2A1, IL12A, IL15, IL2
10	MHC class II antigen presentation38	11.2	ENSG00000233209, ENSG00000232062, ENSG00000206305, HLA-DPA1, HLA-DPB1, HLA-DQA1
11	Graft-versus-host disease20	11.0	KIR3DL1, KIR2DL5A, CD28, CD80, IL1A, IL2
12	Viral myocarditis20	10.9	CD28, CD40LG, CD80, ICAM1, HLA-A, HLA-B
13	Intestinal immune network for IgA production20	10.7	CD28, CD40LG, CD80, ITGA4, IL10, IL15
14	Asthma20	10.5	CD40LG, IL10, IL4, IL5, HLA-DMB, HLA-DPA1
15	Immune response ICOS pathway in T-helper cell10	10.5	REL, CD28, CD80, CD247, ICOS, ICOSLG
16	Molecular Mechanisms of Cancer36	10.5	CD80, ITGA4, ITGAE, IL12B, IL15, IL2
17	Akt Signaling36	10.4	CD28, CD80, ITGAE, IL10, IL12B, IL15
18	STAT3 Pathway36	10.4	CD28, CD80, IL10, IL12A, IL12B, IL15
19	Type I diabetes mellitus20	10.3	CD28, CD80, GZMB, INS, IL12A, IL12B
20	Th17 Differentiation37	10.3	CD28, CD80, IL12B, IL17A, IL1B, IL21
21	Autoimmune thyroid disease20	10.3	CD28, CD40LG, CD80, GZMB, IL10, IL2
22	Th1 Differentiation37	10.2	CD28, CD80, IL10, IL12A, IL12B, IL18
23	IL-6 Pathway36	10.2	CD80, IL10, IL12A, IL12B, IL18, IL22
24	THC Differentiation Pathway36	10.2	CD28, IL10, IL12A, IL12B, IL18, IL18R1
25	Hematopoietic cell lineage20	10.1	CD36, CD8A, CD14, ITGA4, IL1A, IL1B
26	Rheumatoid arthritis20	10.0	CD28, CD80, MMP3, IL15, IL17A, IL18
27	Toxoplasmosis20	10.0	CIITA, CD40LG, IRGM, IL10, IL12A, IL12B
28	PGC1Alpha Pathway36	10.0	CD80, IL12A, IL12B, IL15, IL18, IL1A
29	Allograft rejection20	10.0	CD28, CD40LG, CD80, GZMB, IL10, IL12A
30	Endothelin-1 Signaling Pathway36	10.0	CD80, IL10, IL12A, IL12B, IL18, IL1A
31	Influenza A20	9.9	CIITA, IL12A, IL12B, IL18, IL1A, IL1B
32	PEDF Induced Signaling36	9.8	CD80, IL10, IL12A, IL12B, IL15, IL18
33	Jak-STAT signaling pathway20	9.5	LEP, IL10, IL12A, IL12B, IL15, IL2
34	Tuberculosis20	9.4	VDR, CIITA, CD209, CD14, FCGR2A, FCGR3A
35	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.4	GZMB, IL12B, IL17A, IL1B, IL21, IL22
36	all-trans-Retinoic Acid Signaling in Brain36	9.4	CD80, IL10, IL12A, IL12B, IL15, IL18
37	Malaria20	9.3	SELE, CD36, CD40LG, IL10, IL12A, IL18
38	Cytokine Network36	9.2	IL10, IL12A, IL12B, IL15, IL18, IL1A
39	MIF Mediated Glucocorticoid Regulation36	9.2	CD14, CD80, MIF, IL10, IL12A, IL12B
40	MIF Regulation of Innate Immune Cells36	9.2	CD14, CD80, MIF, IL10, IL12A, IL12B
41	Measles20	9.0	CD209, CD28, IL12A, IL12B, IL1A, IL1B
42	Antioxidant Action of Vitamin-C36	8.9	MYO9B, CD28, CD80, FLNB, IL10, IL12A
43	Chagas disease (American trypanosomiasis)20	8.9	CD247, IL10, IL12A, IL12B, IL1B, IL2
44	Glucocorticoid Receptor Signaling36	8.9	CD80, GTF2A1, IL10, IL12A, IL12B, IL15
45	p38 Signaling36	8.8	CD28, CD80, IL10, IL12A, IL12B, IL15
46	Leishmaniasis20	8.7	ITGA4, FCGR2A, FCGR3A, IL10, IL12A, IL12B
47	Tec Kinases Signaling36	8.6	CD28, CD80, ITGA4, ITGAE, IL10, IL12A
48	TGF-Beta Pathway36	8.5	CD80, IL10, IL12A, IL12B, IL15, IL18
49	Cytokine-cytokine receptor interaction20	8.2	LEP, CD40LG, IL10, IL12A, IL12B, IL15
50	JAK-STAT Pathway36	7.1	UBD, CD80, IL10, IL12A, IL12B, IL15

Compounds related to celiac disease according to GeneDecks:

(show top 50)    (show all 421)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	14.8	REG1A, REL, SERPINE2, BGLAP, KCNJ11, SCG5
2	aspartate32	10.9	VDR, KCNJ11, SCT, CHKB, MT-CYB, LALBA
3	c-peptide32	10.9	KCNJ11, SCT, LEP, IL7, CCK, GHRL
4	mannose32	10.9	CLC, CIITA, CD209, CD79A, CD14, CD80
5	oxygen32 18	11.8	SEPP1, PARK7, CIITA, CHKB, MUC5AC, MT-CYB
6	glucose32	10.8	SEPP1, KCNJ11, SCT, LCT, MT-CYB, LALBA
7	ionomycin32	10.7	IL5, IL7, CALR, ETS1, TNFRSF4, TNFRSF9
8	glutamate32	10.7	NAGS, VDR, KCNJ11, SCG5, LEP, MTHFR
9	ascorbic acid32 18	11.2	VDR, BGLAP, CHKB, MT-CYB, S100B, CD36
10	allergens32	10.1	SCG5, CIITA, LALBA, CD209, CD79A, CD14
11	rituximab32 34 9 9	13.1	CD79A, CD40LG, CD80, FCGR2A, FCGR3A, IL10
12	lipoteichoic acid32	9.9	SELE, CD14, IL10, IL12B, IL18, IL1B
13	cysteine32	9.9	REL, SEPP1, VDR, BGLAP, PARK7, SCG5
14	polysaccharide32	9.8	SELE, SELL, SERPINE2, SCG5, CHKB, LALBA
15	calcitriol32 42 9 18 9	13.7	VDR, BGLAP, CD36, CD14, CD83, IL18R1
16	con a32	9.7	CD28, CD79A, IL10, IL18, IL2, IL21
17	imiquimod32 42 9 9	12.7	IL10, IL12B, IL18, IL1A, IL5, IL6
18	acetylcholine32 9 18 9	12.6	SERPINE2, SCT, LEP, S100B, CD79A, CD40LG
19	pge232	9.6	SELE, SCT, CIITA, MUC5AC, CD14, CD83
20	ribonucleic acid32	9.5	CIITA, MUC5AC, MMP3, GZMB, IL15, IL1A
21	ifn-alpha32	9.5	IRF1, IL10, IL17A, IL18, IL2, IL2RA
22	arginine32	9.4	NAGS, VDR, BGLAP, KCNJ11, SCG5, SCT
23	ccl332	9.4	IL10, IL15, IL18, IL1A, IL1B, IL6
24	paraffin32	9.3	SELL, BGLAP, SCG5, LEP, CHKB, MUC2
25	sulfasalazine32 9 9	11.3	SELE, MTHFR, CD79A, CD40LG, MMP3, IL12B
26	heparin32 9 18 9	12.3	SERPINE2, SEPP1, BGLAP, SCG5, CHKB, LCT
27	lipid32	9.3	KIR3DL1, SELE, SERPINE2, SEPP1, SCG5, SCT
28	fibrinogen32	9.3	SELE, SCG5, LEP, CHKB, LALBA, CD79A
29	norepinephrine32 9 18 9	12.2	SELE, SELL, SCT, LEP, CHKB, S100B
30	alanine32	9.2	SELE, SELL, VDR, BGLAP, SCG5, CIITA
31	pentoxifylline32 9 9	11.2	SELL, CD14, ITGA4, IL10, IL12B, IL18
32	butyrate32	9.1	VDR, ZFP36L1, SCG5, LEP, MUC2, CD14
33	retinoic acid32 42 18	11.0	REL, SELL, VDR, BGLAP, SCT, MTHFR
34	estrogen32	9.0	VDR, BGLAP, LEP, CHKB, MUC2, MUC5AC
35	cholesterol32 9 18 9	12.0	SELE, SCG5, LEP, CIITA, CHKB, MUC2
36	etanercept32 9 9	10.9	LEP, MMP12, MMP3, FCGR2A, FCGR3A, IL10
37	tarc32	8.8	ITGA4, IL10, IL18, IL1A, IL4, IL4R
38	thyroxine32 18	9.6	VDR, BGLAP, SCT, LEP, CIITA, CHKB
39	infliximab32 9 9	10.6	SELE, BGLAP, ITGA4, MMP3, IL10, IL15
40	thalidomide32 42 9 9	11.6	SELL, CD36, CD40LG, IL10, IL18, IL18R1
41	gm-csf32	8.6	CD14, IL10, IL15, IL18, IL1A, IL1B
42	histamine32 18	9.4	SELE, SELL, BGLAP, SCG5, SCT, MUC5AC
43	hydrocortisone32 9 9	10.3	BGLAP, LCT, CD36, CD14, MIF, INS
44	tacrolimus32 34 9 9	11.2	REL, VDR, CHKB, CD28, CD79A, CD36
45	pdtc32	8.1	SELE, IRF1, IL18, IL1A, IL1B, IL4
46	creatinine32	8.1	SELE, SELL, VDR, LEP, MTHFR, MT-CYB
47	nitric oxide32 9 18 9	11.0	REL, SELE, CIITA, CHKB, MUC5AC, MT-CYB
48	cyclosporin a32 42	9.0	REL, VDR, BGLAP, LEP, CIITA, CHKB
49	genistein32 9 18 9	11.0	REG1A, SELE, SELL, VDR, CD28, CD36
50	dexamethasone32 42 34 9 9	10.6	REL, SELL, VDR, BGLAP, SCG5, LEP

Cellular components related to celiac disease according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	11.7	TNFSF4, ERBB3, ICOSLG, ICOS, ICAM1, CCR9
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	11.4	HLA-G, CALR, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA
3	ER to Golgi transport vesicle membrane	GO:012507	11.3	HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-G, HLA-DQB1
4	MHC class II protein complex	GO:042613	11.2	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
5	clathrin-coated endocytic vesicle membrane	GO:030669	11.2	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
6	trans-Golgi network membrane	GO:032588	11.1	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
7	transport vesicle membrane	GO:030658	11.1	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
8	endocytic vesicle membrane	GO:030666	11.1	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
9	lysosomal membrane	GO:005765	10.9	SLC11A2, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
10	MHC class I protein complex	GO:042612	10.8	HFE, HLA-G, HLA-C, HLA-B, HLA-A, MICA
11	plasma membrane	GO:005886	10.4	TNF, TNFRSF14, TNFRSF8, TNFSF13B, TNFSF18, TJP1
12	membrane raft	GO:045121	10.2	DPP4, TLR4, TNF, FAS, CD226, CD14
13	external side of plasma membrane	GO:009897	10.1	TLR2, CTLA4, TNFRSF9, TNFRSF4, TNFRSF14, TNF
14	perinuclear region of cytoplasm	GO:048471	10.0	CTLA4, PLA2G4A, NOS2, HFE, TLR4, PRDX5
15	cell surface	GO:009986	9.7	NOD2, DMD, PTPRK, TNFSF4, TLR2, TGFB1
16	cytosol	GO:005829	8.7	NOS2, NOD2, PLEK, PLA2G4A, SNRPB, PPP6C
17	extracellular region	GO:005576	7.4	PRG2, PRL, DEFA5, DEFB103A, DEFB1, TFRC
18	extracellular space	GO:005615	6.6	TGFB1, CALR, ALB, F2, F3, ICAM1

Biological processes related to celiac disease according to GeneDecks:

(show top 50)    (show all 107)

id	Name	GO ID	Score	Top Affiliating Genes
1	T cell costimulation	GO:031295	11.7	DPP4, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1
2	immune response	GO:006955	11.4	RGS1, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2, HLA-DQA1
3	interferon-gamma-mediated signaling pathway	GO:060333	11.3	PTPN2, STAT1, SOCS1, IRF1, CIITA, IRF4
4	T cell receptor signaling pathway	GO:050852	11.0	HLA-DPB1, HLA-DPA1, MAP3K7, CD247, HLA-DQA1, HLA-DQA2
5	positive regulation of inflammatory response	GO:050729	10.9	TGM2, TLR7, IL18, IL12B, IL1RL1, IL15
6	positive regulation of interferon-gamma production	GO:032729	10.9	IL12B, IL12A, IL18, CD40LG, TLR4, LTA
7	positive regulation of chemokine production	GO:032722	10.8	TLR2, TLR4, TNF, IL18, IL6R, TLR7
8	cytokine-mediated signaling pathway	GO:019221	10.8	CIITA, IFNA2, IFNG, ICAM1, HLA-A, HLA-B
9	negative regulation of interferon-gamma production	GO:032689	10.7	HLA-DRB4, HLA-DRB3, TNFSF4, FOXP3, TLR4, IL10
10	chemokine-mediated signaling pathway	GO:070098	10.7	CCR2, CCR1, CCR4, CCRL2, CCL2, CCR5
11	T-helper 1 type immune response	GO:042088	10.7	IL18, IL12B, HLA-DRB3, HLA-DRB4, TLR4, HLA-DRB1
12	regulation of immune response	GO:050776	10.7	ITGA4, CD247, CD226, CD40LG, CD8A, SELL
13	innate immune response	GO:045087	10.6	DEFB103A, DEFB1, DEFA5, IFNA2, TLR8, TLR7
14	positive regulation of interleukin-6 production	GO:032755	10.5	TNFSF4, CD36, TLR7, TLR4, TLR2, IL1B
15	positive regulation of interleukin-10 production	GO:032733	10.5	CD83, CD40LG, IL21, IL4, IL12B, TNFSF4
16	positive regulation of NF-kappaB import into nucleus	GO:042346	10.5	IL12B, IL1B, TNF, TLR4, TLR7, TLR2
17	positive regulation of osteoclast differentiation	GO:045672	10.5	IL17A, CCL5, CCR1, IL23R, IL12B, IFNG
18	positive regulation of interleukin-17 production	GO:032740	10.4	TGFB1, NOD2, IL23R, IL21, IL18, IL15
19	positive regulation of interleukin-12 production	GO:032735	10.4	TLR4, CD40LG, CD36, IL12B, IL23R, IFNG
20	negative regulation of interleukin-17 production	GO:032700	10.4	IFNG, TNFSF4, TLR4, IL12B, TLR2, IL12A
21	defense response to bacterium	GO:042742	10.3	LALBA, PRG2, IL10, IFNG, NOD2, NOS2
22	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.3	IL6, MIF, CD36, IL5, CD80, TLR4
23	induction of apoptosis	GO:006917	10.3	TNF, TLR2, TGFB1, LTA, RUNX3, TGM2
24	defense response to Gram-positive bacterium	GO:050830	10.3	TLR2, TNF, MBL2, LTA, IL6, IL12A
25	positive regulation of T cell proliferation	GO:042102	10.3	CCL5, IL4, PRKCQ, IFNG, IL15, IL6
26	response to heat	GO:009408	10.2	CCL2, CALCA, SOD1, PEBP1, IRF1, CD14
27	positive regulation of activated T cell proliferation	GO:042104	10.2	IL2, TNFSF4, ICOSLG, IGF1, IL4, IL23R
28	negative regulation of growth of symbiont in host	GO:044130	10.2	IFNG, CD36, LTA, IL10, MBL2, TNF
29	positive regulation of B cell proliferation	GO:030890	10.2	TLR4, TNFRSF4, IL4, IL7, IL5, IL2
30	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.2	CD28, CD80, IRF4, IL1A, PRKCQ, IL1B
31	cell-cell signaling	GO:007267	10.0	IL22, IL2, IL1B, IL18, IL15, IL10
32	lipopolysaccharide-mediated signaling pathway	GO:031663	9.9	TLR2, TNF, TLR4, TGFB1, STAT1, CCL5
33	positive regulation of MHC class II biosynthetic process	GO:045348	9.8	TLR4, IFNG, CIITA, CD40LG, IL10, IL4
34	positive regulation of tumor necrosis factor production	GO:032760	9.8	TLR4, TLR2, IFNG, IL18, IL12B, CD14
35	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.7	MAP3K7, TLR4, TLR2, NFKB1, NLRP3, NOD2
36	cell surface receptor signaling pathway	GO:007166	9.6	CCR5, CCL2, CCR1, IFNA2, IL2RA, IL18RAP
37	regulation of inflammatory response	GO:050727	9.6	NLRP1, NOD2, TNFSF4, PTGS2, PARK7, CALCA
38	cellular response to lipopolysaccharide	GO:071222	9.6	IL10, NOS2, TNFSF4, TNFAIP3, ICAM1, IFNG
39	signal transduction	GO:007165	9.6	MADCAM1, IL1RL2, CCK, IL21, IL4R, CCL2
40	positive regulation of mitosis	GO:045840	9.6	CD28, INS, PEBP1, EGF, TNF, IGF1
41	response to organic nitrogen	GO:010243	9.4	PEBP1, PLA2G4A, PTGS2, IL1RN, IL1B, TGFB2
42	aging	GO:007568	9.4	F3, CALCA, PLA2G4A, TGFB1, PRKCQ, TGFB2
43	response to glucocorticoid stimulus	GO:051384	9.3	FAS, IL6, IL1RN, IL1B, IL10, BCKDHB
44	response to lipopolysaccharide	GO:032496	9.2	F3, IL1A, IL23R, FASLG, FAS, SELE
45	positive regulation of nitric oxide biosynthetic process	GO:045429	9.2	INS, TLR4, TLR2, PTGS2, TNF, ICAM1
46	positive regulation of cell proliferation	GO:008284	9.0	ETS1, EPO, FASLG, IL7, IL6R, IL6
47	anti-apoptosis	GO:006916	8.9	IL2, IGF1, GPX1, CCL2, FAS, IL1B
48	response to hypoxia	GO:001666	8.8	CRP, CREBBP, TNF, CCL2, FAS, IL1A
49	inflammatory response	GO:006954	8.3	SELE, PARK7, CD14, CD40LG, IRGM, MIF
50	response to drug	GO:042493	8.3	LTA, TGFB1, TGFB2, ICAM1, GAD2, GAD1

Molecular functions related to celiac disease according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:032395	11.2	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
2	tumor necrosis factor receptor binding	GO:005164	10.8	STAT1, LTA, TNFSF4, TNFSF18, TNFSF13B, TNFSF13
3	chemokine receptor activity	GO:004950	10.8	CCR9, CCR3, CCRL2, CCR1, CCR5, CCR4
4	peptide antigen binding	GO:042605	10.7	CD209, HLA-DRB1, HLA-DRB3, HLA-DRB4, TAP1
5	C-C chemokine receptor activity	GO:016493	10.7	CCR9, CCR3, CCR1, CCR5, CCR4, CCR2
6	receptor binding	GO:005102	10.5	TNFSF13, TNFSF13B, TNFSF18, TNFSF4, NOS2, LTA
7	transmembrane signaling receptor activity	GO:004888	10.3	KLRB1, KLRD1, TLR2, TLR4, TNFRSF8, ERBB3
8	protease binding	GO:002020	9.9	DPP4, TNFAIP3, TNF, HSPA1B, F3, INS
9	cytokine activity	GO:005125	9.7	IL2, IL21, IL22, IL4, IL5, IL6
10	hormone activity	GO:005179	9.6	EPO, PRL, TG, PYY, CALCA, IGF1
11	protein homodimerization activity	GO:042803	8.5	NFKB1, NOS2, PLEK, CRP, TGFB1, TGFB2
12	growth factor activity	GO:008083	8.3	IL7, IGF1, F2, EGF, TGFB1, TGFB2
13	protein binding	GO:005515	6.5	PTPN2, ELMO1, HFE, TSHR, TLR2, TLR4