SPRUE
MCID: CLC005
MIFTS: 68

Celiac Disease (SPRUE) malady

Categories: Genetic diseases, Rare diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Celiac Disease

Aliases & Descriptions for Celiac Disease:

Name: Celiac Disease 54 38 12 23 50 24 25 29 52 41 42 14 69
Celiac Sprue 12 23 50 24 25
Coeliac Disease 12 50 24 14
Gluten-Sensitive Enteropathy 23 50 24
Nontropical Sprue 23 50 24
Sprue 25 69
Celiac Disease, Susceptibility to 13
Gluten-Induced Enteropathy 50
Childhood Celiac Disease 69
Idiopathic Steatorrhea 12
Gluten Intolerance 50
Gluten Enteropathy 25
Cœliac Disease 23

Characteristics:

GeneReviews:

23

GeneReviews:

23
Penetrance The penetrance of celiac disease is low. of individuals with a celiac-associated hla allele genotype, approximately 3% develop celiac disease. see testing strategies, in a symptomatic individual who is on a gluten-free diet, molecular genetic testing and table 3. see genetic counseling for details regarding risk to family members...

Classifications:



External Ids:

OMIM 54 212750
Disease Ontology 12 DOID:10608
ICD10 33 K90.0
ICD9CM 35 579.0
MeSH 42 D002446
NCIt 47 C26714
UMLS 69 C0007570

Summaries for Celiac Disease

NIH Rare Diseases : 50 celiac disease is an autoimmune disorder that damages the small intestine and inhibits absorption of nutrients. people with celiac disease cannot tolerate gluten, a protein in wheat, rye, barley, and in some products such as medicines, vitamins, and lip balms. when affected people eat food with gluten, or use a product with gluten, the immune system reacts by damaging tiny parts of the lining of the small intestine called villi. because villi normally allow the blood to absorb nutrients from food, affected individuals become malnourished. classic signs and symptoms are caused by inflammation of the gastrointestinal tract and may include diarrhea, weight loss, abdominal pain, swelling, and food intolerance. however, many people have other symptoms involving many body systems, and some people have no symptoms. while celiac disease tends to run in families, it does not follow a specific inheritance pattern. the risk to develop celiac disease is raised by having certain forms of the hla-dqa1 and hla-dqb1 genes. treatment is a lifelong, gluten-free diet. last updated: 2/6/2014

MalaCards based summary : Celiac Disease, also known as celiac sprue, is related to hypermobility syndrome and rheumatoid arthritis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Celiac Disease is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are NF-kappaB Signaling and Allograft rejection. The drugs Ethanol and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and thyroid, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that is caused by a reaction located in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has symptom abdominal pain, has symptom constipation, has symptom diarrhea, has symptom nausea and vomiting, and has symptom loss of appetite.

Genetics Home Reference : 25 Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.

OMIM : 54 Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy (GSE), is a multifactorial disorder of the... (212750) more...

MedlinePlus : 41 celiac disease is an immune disease in which people can't eat gluten because it will damage their small intestine. if you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. gluten is a protein found in wheat, rye, and barley. it is found mainly in foods but may also be in other products like medicines, vitamins and supplements, lip balm, and even the glue on stamps and envelopes. celiac disease affects each person differently. symptoms may occur in the digestive system, or in other parts of the body. one person might have diarrhea and abdominal pain, while another person may be irritable or depressed. irritability is one of the most common symptoms in children. some people have no symptoms. celiac disease is genetic. blood tests can help your doctor diagnose the disease. your doctor may also need to examine a small piece of tissue from your small intestine. treatment is a diet free of gluten. nih: national institute of diabetes and digestive and kidney diseases

Wikipedia : 71 Coeliac disease, also spelled celiac disease, is a long term autoimmune disorder primarily affecting the... more...

GeneReviews: NBK1727

Related Diseases for Celiac Disease

Diseases in the Celiac Disease family:

Celiac Disease 7 Celiac Disease 8
Celiac Disease 3 Celiac Disease 9
Celiac Disease 10 Celiac Disease 11
Celiac Disease 6 Celiac Disease 2
Celiac Disease 12 Celiac Disease 13
Celiac Disease 5 Celiac Disease 4

Diseases related to Celiac Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
id Related Disease Score Top Affiliating Genes
1 hypermobility syndrome 29.8 CTLA4 PTPN22 TPO
2 rheumatoid arthritis 29.8 CD79A CTLA4 HLA-DQA1 HLA-DQB1 IL15 PTPN22
3 celiac disease 3 12.1
4 celiac disease 4 12.1
5 celiac disease 13 12.1
6 celiac disease 5 12.1
7 celiac disease 12 12.1
8 celiac disease 9 12.1
9 celiac disease 10 12.1
10 celiac disease 11 12.1
11 celiac disease 7 12.1
12 celiac disease 6 12.1
13 celiac disease 8 12.1
14 celiac disease 2 12.1
15 refractory celiac disease 11.9
16 osteomalacia 11.1
17 down syndrome 11.0
18 rickets 11.0
19 wheat allergy 11.0
20 collagenous gastritis 11.0
21 duodenum cancer 11.0
22 autoimmune disease, multisystem, infantile-onset 10.8
23 osmotic diarrhea 10.8
24 epilepsy with bilateral occipital calcifications 10.8
25 epilepsy occipital calcifications 10.8
26 iga glomerulonephritis 10.7
27 cholangitis, primary sclerosing 10.7
28 opsoclonus-myoclonus syndrome 10.7
29 brittle diabetes 10.7
30 diarrhea 5, with tufting enteropathy, congenital 10.7
31 bile acid malabsorption, primary 10.7
32 osteogenesis imperfecta congenita, microcephaly, and cataracts 10.4 HLA-DQA1 HLA-DQB1
33 adenocarcinoma of penis 10.4 CTLA4 HLA-DQA1
34 pyridoxine-responsive sideroblastic anemia 10.4 CD79A TGM2
35 hemoglobin d disease 10.4 HLA-DQA1 HLA-DQB1
36 cutaneous solitary mastocytoma 10.4 CD79A TGM2
37 good syndrome 10.4 CD79A HLA-DQB1 TGM2
38 amyotrophic lateral sclerosis type 10 10.4 CD79A TGM2
39 anaerobic meningitis 10.4 CD79A HLA-DQB1 TGM2
40 deep dermatophytosis 10.4 HLA-DQB1 IL15 MYO9B
41 bilateral parasagittal parieto-occipital polymicrogyria 10.4 HLA-DQA1 HLA-DQB1
42 right bundle branch block 10.4 CD79A TG
43 cone-rod dystrophy 10 10.4 CD79A SH2B3
44 fibrous meningioma 10.3 TG TPO
45 atheroembolism of kidney 10.3 CD79A TG
46 conjunctival deposit 10.3 CTLA4 TG TPO
47 autoimmune hemolytic anemia 10.3 CTLA4 TG TPO
48 complement component 8 deficiency 10.3 CTLA4 PTPN22
49 barbiturate abuse 10.3 CD79A HLA-DQA1 HLA-DQB1 MYO9B TGM2
50 neuhauser daly magnelli syndrome 10.3 TG TPO

Comorbidity relations with Celiac Disease via Phenotypic Disease Network (PDN):


Chylomicron Retention Disease Deficiency Anemia
Hypothyroidism Iron Deficiency Anemia
Protein-Energy Malnutrition Tropical Sprue

Graphical network of the top 20 diseases related to Celiac Disease:



Diseases related to Celiac Disease

Symptoms & Phenotypes for Celiac Disease

Symptoms by clinical synopsis from OMIM:

212750

Clinical features from OMIM:

212750

Symptoms:

12
  • abdominal pain
  • constipation
  • diarrhea
  • nausea
  • loss of appetite

Human phenotypes related to Celiac Disease:

32 (show all 40)
id Description HPO Frequency HPO Source Accession
1 ataxia 32 HP:0001251
2 arthralgia 32 HP:0002829
3 seizures 32 HP:0001250
4 abdominal pain 32 HP:0002027
5 vomiting 32 HP:0002013
6 diarrhea 32 HP:0002014
7 depression 32 HP:0000716
8 failure to thrive 32 HP:0001508
9 cerebral calcification 32 HP:0002514
10 short stature 32 HP:0004322
11 delayed puberty 32 HP:0000823
12 rickets 32 HP:0002748
13 type i diabetes mellitus 32 HP:0100651
14 osteoporosis 32 HP:0000939
15 weight loss 32 HP:0001824
16 anxiety 32 HP:0000739
17 elevated hepatic transaminases 32 HP:0002910
18 postnatal growth retardation 32 HP:0008897
19 celiac disease 32 HP:0002608
20 hypocalcemia 32 HP:0002901
21 iron deficiency anemia 32 HP:0001891
22 thrombocytosis 32 HP:0001894
23 vitamin d deficiency 32 HP:0100512
24 alopecia 32 HP:0001596
25 eczema 32 HP:0000964
26 lymphoma 32 HP:0002665
27 infertility 32 HP:0000789
28 abdominal distention 32 HP:0003270
29 iga deficiency 32 HP:0002720
30 macrocytic anemia 32 HP:0001972
31 polyneuropathy 32 HP:0001271
32 recurrent aphthous stomatitis 32 HP:0011107
33 prolonged partial thromboplastin time 32 HP:0003645
34 prolonged prothrombin time 32 HP:0008151
35 vitamin k deficiency 32 HP:0011892
36 steatorrhea 32 HP:0002570
37 hypoplasia of dental enamel 32 HP:0006297
38 abnormality of the abdominal wall 32 HP:0004298
39 vitamin b12 deficiency 32 HP:0100502
40 folate deficiency 32 HP:0100507

UMLS symptoms related to Celiac Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Celiac Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.85 CCR9 CTLA4 HLA-DQA1 HLA-DQB1 IL15 IRF1
2 hematopoietic system MP:0005397 9.83 SH2B3 TG TGM2 TPO CCR9 CD79A
3 immune system MP:0005387 9.47 CCR9 CD79A CTLA4 HLA-DQA1 HLA-DQB1 IL15

Drugs & Therapeutics for Celiac Disease

Drugs for Celiac Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 156)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
2
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3 23214-92-8 31703
3
Ethiodized oil Approved Phase 4,Phase 2,Phase 3 8008-53-5
4
Pancrelipase Approved Phase 4,Phase 3,Phase 1,Early Phase 1 53608-75-6
5
Doxil Approved June 1999 Phase 4,Phase 2,Phase 3 31703
6 Anti-Infective Agents Phase 4,Phase 3
7 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1
8 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1
9 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Early Phase 1
10 Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1
11 Hormones Phase 4,Phase 2,Phase 3,Early Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1
13 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
14 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
15 pancreatin Phase 4,Phase 3,Phase 1,Early Phase 1
16 Anti-Infective Agents, Local Phase 4,Phase 3
17 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
18 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
19 Estrogens Phase 4
20 Gentamicins Phase 4
21 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
22
Capecitabine Approved, Investigational Phase 2, Phase 3 154361-50-9 60953
23
Cisplatin Approved Phase 2, Phase 3 15663-27-1 84093 441203 2767
24
Fluorouracil Approved Phase 3 51-21-8 3385
25
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
26
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
27
Simvastatin Approved Phase 2, Phase 3,Phase 1 79902-63-9 54454
28
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
29
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
30
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
31
Levobupivacaine Approved Phase 2, Phase 3 27262-47-1 92253
32
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
33
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
34
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 5310940 9887054 6857599, 9887054 43805
35 Anti-Inflammatory Agents Phase 2, Phase 3, Early Phase 1
36 Peripheral Nervous System Agents Phase 2, Phase 3, Early Phase 1
37 Antimetabolites Phase 2, Phase 3,Phase 1
38 Immunosuppressive Agents Phase 3
39 Antiemetics Phase 2, Phase 3
40 Autonomic Agents Phase 2, Phase 3
41 glucocorticoids Phase 2, Phase 3
42 Methylprednisolone acetate Phase 2, Phase 3
43 Methylprednisolone Hemisuccinate Phase 2, Phase 3
44 Neuroprotective Agents Phase 2, Phase 3
45 Prednisolone acetate Phase 2, Phase 3
46 Prednisolone hemisuccinate Phase 2, Phase 3
47 Prednisolone phosphate Phase 2, Phase 3
48 Protective Agents Phase 2, Phase 3
49 Anticholesteremic Agents Phase 2, Phase 3,Phase 1
50 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2, Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 249)
id Name Status NCT ID Phase
1 Prospective Study of Celiac Block Injection: 1 vs. 2 Completed NCT00583479 Phase 4
2 Endoscopic Ultrasound-guided Celiac Plexus Neurolysis (EUS-CPN)With Alcohol in Unresectable Pancreatic Cancer: a Pilot Study Completed NCT00578279 Phase 4
3 Efficacy and Safety of Drug Eluting Beads TACE in Treatment of HCC in Egyptian Patients Completed NCT03007225 Phase 4
4 Pancreatic Enzyme Supplementation for Celiac Disease Recruiting NCT02475369 Phase 4
5 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Recruiting NCT02917863 Phase 4
6 Prucalopride Prior to Small Bowel Capsule Endoscopy Not yet recruiting NCT02806206 Phase 4
7 Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase Terminated NCT01865695 Phase 4
8 Randomized Control Trial (RCT) of Transarterial Chemoembolization (TACE) Versus TACE and Oral Drug Therapy in the Treatment of Unresectable Hepatocellular Carcinoma Unknown status NCT00522405 Phase 2, Phase 3
9 The ARTERY FIRST Approach for Resection of Pancreatic Head Cancer Unknown status NCT01332773 Phase 3
10 Effect of Addition of Short Course of Prednisolone to Gluten Free Diet in Naive Celiac Disease Patients Completed NCT01045837 Phase 2, Phase 3
11 Protocol for Correlating Enteropathic Severity and Small Intestinal CYP3A4 Activity in Patients With Celiac Disease Completed NCT01338324 Phase 2, Phase 3
12 HLA-DQ2-gliadin Tetramer for Diagnosis of Celiac Disease Completed NCT01100099 Phase 2, Phase 3
13 Intraoperative Celiac Plexus Neurolysis for Patients With Operable Pancreatic and Periampullary Cancer Completed NCT00806611 Phase 3
14 Trial of Endoscopic Ultrasound (EUS) - Guided Celiac Plexus Neurolysis Completed NCT00974948 Phase 3
15 Randomized Trial of EUS Neurolysis in Pancreas Cancer Completed NCT00279292 Phase 3
16 Efficacy of EUS-guided Celiac Plexus Blockade in Chronic Pancreatitis Completed NCT00658736 Phase 3
17 Gluten Sensitivity in Non-Celiac Patients Completed NCT01485341 Phase 3
18 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
19 Left Celiac Plexus Resection for Pancreatic Cancer at the Body and Tail Recruiting NCT02117895 Phase 3
20 EUS-guided CGN for Inoperable Cancer Recruiting NCT02356640 Phase 2, Phase 3
21 Resection of the Nerve Plexus on the Right Half of Celiac and SMA Associated With Extended Pancreatoduodenectomy in the Surgical Treatment for Adenocarcinoma of the Head of Pancreas Recruiting NCT02514928 Phase 3
22 Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis Recruiting NCT01318590 Phase 3
23 Comparison of SEEOX and SOX Regimens in Stage ⅢB/ⅢC Gastric Cancer Patients Recruiting NCT02338518 Phase 3
24 Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation Recruiting NCT02584283 Phase 3
25 Phase III Trial Investigating the Potential Benefit of Adjvant Chemotherapy for Small Bowel Adenocarcinoma Not yet recruiting NCT02502370 Phase 3
26 A Phase III Study of En Bloc Versus Non-En Bloc Esophagectomy in Esophageal Cancer Terminated NCT00760604 Phase 3
27 Evaluation of the Efficacy and Safety of ALV003 in Symptomatic in Celiac Disease Patients Unknown status NCT01917630 Phase 2
28 Wheat Flour Treatment With Microbial Transglutaminase and Lysine Ethyl Ester: New Frontiers in Celiac Disease Treatment. Unknown status NCT02472119 Phase 2
29 Celiac Plexus Radiosurgery for Pain Management Unknown status NCT02356406 Phase 2
30 Efficacy Study of Acupuncture to Treat the Upper Abdominal Pain of Cancer Patients Unknown status NCT01913574 Phase 2
31 Phase IIb Study to Study the Efficacy of AT1001 to Treat Celiac Disease Completed NCT00492960 Phase 2
32 Safety and Tolerability Study of AT1001 in Celiac Disease Subjects Completed NCT00362856 Phase 2
33 A Double-blind Placebo-controlled Study to Evaluate Larazotide Acetate for the Treatment of Celiac Disease Completed NCT01396213 Phase 2
34 A Phase II Study of CCX282-B in Patients With Celiac Disease Completed NCT00540657 Phase 2
35 Safety and Efficacy of ALV003 for the Treatment of Celiac Disease Completed NCT00959114 Phase 2
36 Safety and Efficacy of Varying Methods of ALV003 Administration for the Treatment of Celiac Disease Completed NCT01255696 Phase 2
37 Cytokine Profile in Children With Celiac Disease Completed NCT02244047 Phase 1, Phase 2
38 Effect of Aspergillus Niger Prolyl Endoprotease (AN-PEP) Enzyme on the Effects of Gluten Ingestion in Patients With Coeliac Disease Completed NCT00810654 Phase 1, Phase 2
39 Study of the Efficacy of AT1001 (Larazotide Acetate) to Treat Celiac Disease Completed NCT00889473 Phase 2
40 Desensitising Celiac Disease Patients With the Human Hookworm Completed NCT01661933 Phase 1, Phase 2
41 Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity Completed NCT00671138 Phase 2
42 Safety of Prolonged Administration of Triticum Monococcum in Celiac Disease Completed NCT02220166 Phase 2
43 Randomized, Double-Blind, Placebo-Controlled Study of Larazotide Acetate (AT-1001) in Active Celiac Disease Completed NCT00620451 Phase 2
44 Safety and Systemic Exposure Study of BL-7010 in Well-Controlled Celiac Patients. Completed NCT01990885 Phase 1, Phase 2
45 FOLFOXIRI as Primary Treatment for Locally Advanced Pancreatic Cancer Completed NCT02351219 Phase 2
46 Prospective Phase II Trial on Prophylactic Perihepatic Lymphadenectomy in Patients With Colorectal Cancer With Liver Metastasis Completed NCT01565811 Phase 2
47 Cetuximab and Radiation Therapy for Surgically Resectable Esophageal and Gastroesophageal (GE) Junction Carcinomas Completed NCT00319735 Phase 2
48 Evaluation of Branch Endografts in the Treatment of Aortic Aneurysms Recruiting NCT01524211 Phase 2
49 Study of Enzyme Supplements to Treat Celiac Disease Active, not recruiting NCT00962182 Phase 1, Phase 2
50 A Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Celiac Disease Active, not recruiting NCT02637141 Phase 2

Search NIH Clinical Center for Celiac Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Celiac Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Celiac Disease:
Regenerative ColoTherapy
Embryonic/Adult Cultured Cells Related to Celiac Disease:
Adipose-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: celiac disease

Genetic Tests for Celiac Disease

Genetic tests related to Celiac Disease:

id Genetic test Affiliating Genes
1 Celiac Disease 29 24 HLA-DQB1

Anatomical Context for Celiac Disease

MalaCards organs/tissues related to Celiac Disease:

39
Small Intestine, Testes, Thyroid, T Cells, Kidney, Bone, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Celiac Disease:

18
Small Intestine To Gliadin

Publications for Celiac Disease

Articles related to Celiac Disease:

(show top 50) (show all 1446)
id Title Authors Year
1
The eyes of children with celiac disease. ( 28087348 )
2017
2
Association of PTPN22 Single Nucleotide Polymorphisms with Celiac Disease. ( 28481156 )
2017
3
Perspective: Gluten-Free Products for Patients with Celiac Disease Should Not Contain Trace Levels. ( 28507006 )
2017
4
Splenic dysfunction from celiac disease resulting in severe babesiosis. ( 28286145 )
2017
5
Impact of type 1 diabetes mellitus and celiac disease on nutrition and quality of life. ( 28067892 )
2017
6
No Need for Routine Endoscopy in Children With Celiac Disease on a Gluten-free diet. ( 28489675 )
2017
7
Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study. ( 28465308 )
2017
8
Splenic volume differentiates complicated and non-complicated celiac disease. ( 28507749 )
2017
9
Gluten-free diet is not recommended for people without celiac disease. ( 28468759 )
2017
10
Migraine, Celiac Disease and Intestinal Microbiota. ( 28507424 )
2017
11
Cortical involvement in celiac disease before and after long-term gluten-free diet: A Transcranial Magnetic Stimulation study. ( 28489931 )
2017
12
The association between semaphorin 3A levels and gluten-free diet in patients with celiac disease. ( 28502679 )
2017
13
Association of Autoimmune Hepatitis and Celiac Disease: Role of Gluten-Free Diet in Reversing Liver Dysfunction. ( 28491884 )
2017
14
Celiac Disease Symptom Resolution: Effectiveness of the Gluten Free Diet. ( 28514243 )
2017
15
Allelic frequencies of the hs1.2 enhancer within the immunoglobulin heavy chain region in Dayton, Ohio patients screened for celiac disease with duodenal biopsy. ( 28473300 )
2017
16
Salivary Gluten Degradation and Oral Microbial Profiles in Health and Celiac Disease. ( 28087531 )
2017
17
A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease. ( 28508029 )
2017
18
Whole exome sequencing of a consanguineous family identifies the possible modifying effect of a globally rare AK5 allelic variant in celiac disease development among Saudi patients. ( 28505210 )
2017
19
Anorexia nervosa of the restrictive type and celiac disease in adolescence. ( 28496327 )
2017
20
Celiac disease prevalence is not increased in patients with functional dyspepsia. ( 28079237 )
2017
21
Dietary compliance in celiac disease. ( 28487600 )
2017
22
Microwave-based treatments of wheat kernels do not abolish gluten epitopes implicated in celiac disease. ( 28088490 )
2017
23
Characterization of globulin storage proteins of a low prolamin cereal species in relation to celiac disease. ( 28051174 )
2017
24
Cross-sectional imaging in refractory celiac disease. ( 28084545 )
2017
25
Comprehensive Computational Analysis of GWAS Loci Identifies CCR2 as a Candidate gene for Celiac Disease Pathogenesis. ( 28059456 )
2017
26
Thiol/disulphide homeostasis in celiac disease. ( 28533921 )
2017
27
Clinical and biological correlations in celiac disease in children: the prospective single experience of a romanian tertiary center: A case-control study (Strobe-Compliant study). ( 28514313 )
2017
28
Retrospective evaluation of pregnant women with celiac disease. ( 28506952 )
2017
29
Celiac Disease and Nonceliac Gluten Sensitivity. ( 28502438 )
2017
30
Celiac disease: a clinical review. ( 28078381 )
2017
31
Serological prevalence of celiac disease in Brazilian population of multiple sclerosis, neuromyelitis optica and myelitis. ( 27645359 )
2016
32
Distal Renal Tubular Acidosis Associated with Celiac Disease and Thyroiditis. ( 27889732 )
2016
33
Computed Tomographic presentation of obstructive jejunal adenocarcinoma associated with celiac disease and incomplete intestinal malrotation. ( 26670410 )
2016
34
An unusual case of hypercalcemia in a patient of concomitant hypoparathyroidism and celiac disease. ( 27252747 )
2016
35
Ancestry-based stratified analysis of Immunochip data identifies novel associations with celiac disease. ( 27650971 )
2016
36
Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer. ( 27689204 )
2016
37
Allergen advisory statements for wheat: do they help US consumers with celiac disease make safe food choices? ( 27623978 )
2016
38
Celiac Disease is Misdiagnosed Based on Serology Only in a Substantial Proportion of Patients. ( 27636410 )
2016
39
Environmental factors in the etiology of type 1 diabetes, celiac disease, and narcolepsy. ( 27411439 )
2016
40
Refractory Hypoparathyroidism in a Child with Celiac Disease. ( 26964284 )
2016
41
Genome Sequence of Kocuria palustris Strain CD07_3 Isolated from the Duodenal Mucosa of a Celiac Disease Patient. ( 27125478 )
2016
42
Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease. ( 26153762 )
2016
43
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome and celiac disease in a 13-year-old girl: further evidence for autoimmunity? ( 26352082 )
2016
44
Does Celiac Disease Influence Survival in Sepsis? A Nationwide Longitudinal Study. ( 27124735 )
2016
45
Innate and adaptive immunity in self-reported nonceliac gluten sensitivity versus celiac disease. ( 27130911 )
2016
46
A Successful HSCT in a Girl with Novel LRBA Mutation with Refractory Celiac Disease. ( 26686526 )
2016
47
Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients. ( 27644734 )
2016
48
Bifidobacterium infantis NLS Super Strain Reduces the Expression of I+-Defensin-5, a Marker of Innate Immunity, in the Mucosa of Active Celiac Disease Patients. ( 27636409 )
2016
49
Increased Incidence of Thyroid Disease in Patients with Celiac Disease: A Systematic Review and Meta-Analysis. ( 28030626 )
2016
50
Screening of celiac disease in children with Henoch-Schoenlein purpura. ( 26792132 )
2016

Variations for Celiac Disease

Expression for Celiac Disease

Search GEO for disease gene expression data for Celiac Disease.

Pathways for Celiac Disease

GO Terms for Celiac Disease

Cellular components related to Celiac Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.17 CCR9 CD79A CTLA4 HLA-DQA1 IL15 KLRK1
2 MHC class II protein complex GO:0042613 8.96 HLA-DQA1 HLA-DQB1

Biological processes related to Celiac Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.63 CCR9 CTLA4 HLA-DQA1 HLA-DQB1 IL15 IL18RAP
2 interferon-gamma-mediated signaling pathway GO:0060333 9.5 HLA-DQA1 HLA-DQB1 IRF1
3 embryonic hemopoiesis GO:0035162 9.46 SH2B3 TPO
4 regulation of innate immune response GO:0045088 9.43 IRF1 PTPN22
5 immune system process GO:0002376 9.43 CD79A CTLA4 HLA-DQA1 IRF1 KLRK1 PTPN22
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.4 HLA-DQA1 HLA-DQB1
7 hormone biosynthetic process GO:0042446 9.37 TG TPO
8 negative regulation of regulatory T cell differentiation GO:0045590 9.26 CTLA4 IRF1
9 T cell costimulation GO:0031295 8.92 CTLA4 HLA-DQA1 HLA-DQB1 KLRK1
10 signal transduction GO:0007165 10.08 CCR9 IL15 IL18RAP KLRK1 MYO9B SH2B3

Molecular functions related to Celiac Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.62 HLA-DQA1 HLA-DQB1

Sources for Celiac Disease

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