CELIAC3
MCID: CLC048
MIFTS: 21

Celiac Disease 3 (CELIAC3) malady

Categories: Genetic diseases, Gastrointestinal diseases, Rare diseases, Immune diseases

Aliases & Classifications for Celiac Disease 3

Aliases & Descriptions for Celiac Disease 3:

Name: Celiac Disease 3 54 66 29
Celiac Disease, Susceptibility to, 3 13
Gluten-Sensitive Enteropathy 3 66
Celiac3 66

Classifications:



External Ids:

OMIM 54 609755
MedGen 40 C1857845
MeSH 42 D002446

Summaries for Celiac Disease 3

OMIM : 54 Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy, is a multifactorial disorder of the small... (609755) more...

MalaCards based summary : Celiac Disease 3, also known as celiac disease, susceptibility to, 3, is related to celiac disease. An important gene associated with Celiac Disease 3 is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4). The drugs Doxorubicin and Ethiodized oil have been mentioned in the context of this disorder. Affiliated tissues include small intestine.

UniProtKB/Swiss-Prot : 66 Celiac disease 3: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten- containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.

Related Diseases for Celiac Disease 3

Diseases in the Celiac Disease family:

Celiac Disease 7 Celiac Disease 8
Celiac Disease 3 Celiac Disease 9
Celiac Disease 10 Celiac Disease 11
Celiac Disease 6 Celiac Disease 2
Celiac Disease 12 Celiac Disease 13
Celiac Disease 5 Celiac Disease 4

Diseases related to Celiac Disease 3 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 celiac disease 9.9

Symptoms & Phenotypes for Celiac Disease 3

Clinical features from OMIM:

609755

Drugs & Therapeutics for Celiac Disease 3

Drugs for Celiac Disease 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3 23214-92-8 31703
2
Ethiodized oil Approved Phase 4,Phase 2,Phase 3 8008-53-5
3
Pancrelipase Approved Phase 4,Phase 3,Early Phase 1 53608-75-6
4
Doxil Approved June 1999 Phase 4,Phase 2,Phase 3 31703
5 Anesthetics Phase 4,Phase 2,Phase 3
6 Anti-Bacterial Agents Phase 4,Phase 3
7 Antibiotics, Antitubercular Phase 4,Phase 3
8 Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1
9 Hormones Phase 4,Phase 2,Phase 3,Early Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1
11 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
12 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Early Phase 1
13 pancreatin Phase 4,Phase 3,Early Phase 1
14 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
15 Estrogens Phase 4
16 Gentamicins Phase 4
17 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
18
Capecitabine Approved, Investigational Phase 2, Phase 3 154361-50-9 60953
19
Cisplatin Approved Phase 2, Phase 3 15663-27-1 84093 441203 2767
20
Ethanol Approved Phase 3,Phase 2 64-17-5 702
21
Fluorouracil Approved Phase 3 51-21-8 3385
22
Simvastatin Approved Phase 2, Phase 3 79902-63-9 54454
23
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
24
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
25
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
26
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
27
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
28
Levobupivacaine Approved Phase 2, Phase 3 27262-47-1 92253
29
Epirubicin Approved Phase 3 56420-45-2 41867
30
Etoposide Approved Phase 3 33419-42-0 36462
31
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599, 9887054 43805
32 Antimetabolites Phase 2, Phase 3
33 Anti-Inflammatory Agents Phase 2, Phase 3, Early Phase 1
34 Peripheral Nervous System Agents Phase 2, Phase 3, Early Phase 1
35 Immunosuppressive Agents Phase 3
36 Anticholesteremic Agents Phase 2, Phase 3
37 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2, Phase 3
38 Hypolipidemic Agents Phase 2, Phase 3
39 Lipid Regulating Agents Phase 2, Phase 3
40 Antiemetics Phase 2, Phase 3
41 Autonomic Agents Phase 2, Phase 3
42 glucocorticoids Phase 2, Phase 3
43 Methylprednisolone acetate Phase 2, Phase 3
44 Methylprednisolone Hemisuccinate Phase 2, Phase 3
45 Neuroprotective Agents Phase 2, Phase 3
46 Prednisolone acetate Phase 2, Phase 3
47 Prednisolone hemisuccinate Phase 2, Phase 3
48 Prednisolone phosphate Phase 2, Phase 3
49 Protective Agents Phase 2, Phase 3
50 Anti-Infective Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 90)
id Name Status NCT ID Phase
1 Efficacy and Safety of Drug Eluting Beads TACE in Treatment of HCC in Egyptian Patients Completed NCT03007225 Phase 4
2 Pancreatic Enzyme Supplementation for Celiac Disease Recruiting NCT02475369 Phase 4
3 Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase Terminated NCT01865695 Phase 4
4 Randomized Control Trial (RCT) of Transarterial Chemoembolization (TACE) Versus TACE and Oral Drug Therapy in the Treatment of Unresectable Hepatocellular Carcinoma Unknown status NCT00522405 Phase 2, Phase 3
5 The ARTERY FIRST Approach for Resection of Pancreatic Head Cancer Unknown status NCT01332773 Phase 3
6 Protocol for Correlating Enteropathic Severity and Small Intestinal CYP3A4 Activity in Patients With Celiac Disease Completed NCT01338324 Phase 2, Phase 3
7 Trial of Endoscopic Ultrasound (EUS) - Guided Celiac Plexus Neurolysis Completed NCT00974948 Phase 3
8 HLA-DQ2-gliadin Tetramer for Diagnosis of Celiac Disease Completed NCT01100099 Phase 2, Phase 3
9 Randomized Trial of EUS Neurolysis in Pancreas Cancer Completed NCT00279292 Phase 3
10 Effect of Addition of Short Course of Prednisolone to Gluten Free Diet in Naive Celiac Disease Patients Completed NCT01045837 Phase 2, Phase 3
11 Intraoperative Celiac Plexus Neurolysis for Patients With Operable Pancreatic and Periampullary Cancer Completed NCT00806611 Phase 3
12 Gluten Sensitivity in Non-Celiac Patients Completed NCT01485341 Phase 3
13 Efficacy of EUS-guided Celiac Plexus Blockade in Chronic Pancreatitis Completed NCT00658736 Phase 3
14 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
15 EUS-guided CGN for Inoperable Cancer Recruiting NCT02356640 Phase 2, Phase 3
16 Left Celiac Plexus Resection for Pancreatic Cancer at the Body and Tail Recruiting NCT02117895 Phase 3
17 Resection of the Nerve Plexus on the Right Half of Celiac and SMA Associated With Extended Pancreatoduodenectomy in the Surgical Treatment for Adenocarcinoma of the Head of Pancreas Recruiting NCT02514928 Phase 3
18 Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis Recruiting NCT01318590 Phase 3
19 Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation Recruiting NCT02584283 Phase 3
20 Comparison of SEEOX and SOX Regimens in Stage ⅢB/ⅢC Gastric Cancer Patients Recruiting NCT02338518 Phase 3
21 Phase III Trial Investigating the Potential Benefit of Adjvant Chemotherapy for Small Bowel Adenocarcinoma Not yet recruiting NCT02502370 Phase 3
22 A Phase III Study of En Bloc Versus Non-En Bloc Esophagectomy in Esophageal Cancer Terminated NCT00760604 Phase 3
23 Wheat Flour Treatment With Microbial Transglutaminase and Lysine Ethyl Ester: New Frontiers in Celiac Disease Treatment. Unknown status NCT02472119 Phase 2
24 Efficacy Study of Acupuncture to Treat the Upper Abdominal Pain of Cancer Patients Unknown status NCT01913574 Phase 2
25 Desensitising Celiac Disease Patients With the Human Hookworm Completed NCT01661933 Phase 1, Phase 2
26 Cytokine Profile in Children With Celiac Disease Completed NCT02244047 Phase 1, Phase 2
27 Phase IIb Study to Study the Efficacy of AT1001 to Treat Celiac Disease Completed NCT00492960 Phase 2
28 Randomized, Double-Blind, Placebo-Controlled Study of Larazotide Acetate (AT-1001) in Active Celiac Disease Completed NCT00620451 Phase 2
29 Safety and Systemic Exposure Study of BL-7010 in Well-Controlled Celiac Patients. Completed NCT01990885 Phase 1, Phase 2
30 Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Type II Refractory Celiac Disease Active, not recruiting NCT02633020 Phase 2
31 Study of Enzyme Supplements to Treat Celiac Disease Active, not recruiting NCT00962182 Phase 1, Phase 2
32 Study of Extensive Clinical Target Volumes in Postoperative Radiotherapy Concurrent With Chemotherapy for Esophageal Squamous Cell Carcinoma Not yet recruiting NCT02916511 Phase 2
33 Transcatheter Arterial Chemoembolization (TACE) in Combination With Arsenic Trioxide Versus TACE in the Treatment of Middle-advanced Primary Hepatocellular Carcinoma (HCC) Patients Not yet recruiting NCT02956772 Phase 2
34 Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer Terminated NCT01285102 Phase 2
35 Comparison of the Laparoscopy-Assisted Distal Gastrectomy and Open Distal Gastrectomy for Advanced Gastric Cancer Unknown status NCT00741676 Phase 1
36 Safety and Tolerability of Nexvax2 in Subjects With Celiac Disease Completed NCT02528799 Phase 1
37 Safety Study of Nexvax2 in Subjects With Coeliac Disease Completed NCT00879749 Phase 1
38 Antibody Treatment for Advanced Celiac Disease Recruiting NCT01893775 Phase 1
39 Hookworm Therapy for Coeliac Disease Not yet recruiting NCT02754609 Phase 1
40 Comparison of Engerix B Vaccine Versus Sci-B-Vac Vaccine in Celiac Patients Unknown status NCT01159457
41 Randomized, Controlled Trial of Endoscopic Ultrasound-Guided Bilateral Celiac Plexus Neurolysis vs Celiac Ganglia Neurolysis to Control Pain in Inoperable Pancreatic Cancer Patients With Inadequate Pain Control by Pain Killer Unknown status NCT02220062
42 Validation of New Tests for Gastrointestinal (GI) Permeability Unknown status NCT00943345 Early Phase 1
43 Effect of Laparoscopy-Assisted Distal Gastrectomy for Locally Advanced Gastric Cancer Unknown status NCT02464215
44 IS There a Correlation Between Sypmtoms of Gastroparesis and the Duration of Video Caspule Retention in the Stomach Unknown status NCT01858220
45 Secretin-Assisted Computed Tomography Scan and Magnetic Resonance Imaging in Improving Pancreatic Tumor Conspicuity Unknown status NCT01371240 Early Phase 1
46 Efficacy of Postoperative Adjuvant Treatments for Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Unknown status NCT01033578
47 Prevalence of Gluten Sensitivity in Irritable Bowel Syndrome: The First Study in Paediatrics. Unknown status NCT02431585
48 Rifaximin for the Treatment of Persistent Symptoms in Patients With Celiac Disease Completed NCT01137955
49 Clinical Relevance of Typing HLA-DR7-DQ2 Completed NCT01813383
50 Clinical Trial on the Effects of Bifidobacterium Infantis in Active Celiac Disease Completed NCT01257620

Search NIH Clinical Center for Celiac Disease 3

Genetic Tests for Celiac Disease 3

Genetic tests related to Celiac Disease 3:

id Genetic test Affiliating Genes
1 Celiac Disease 3 29

Anatomical Context for Celiac Disease 3

MalaCards organs/tissues related to Celiac Disease 3:

39
Small Intestine

Publications for Celiac Disease 3

Variations for Celiac Disease 3

ClinVar genetic disease variations for Celiac Disease 3:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CTLA4 NM_005214.4(CTLA4): c.49A> G (p.Thr17Ala) single nucleotide variant risk factor rs231775 GRCh37 Chromosome 2, 204732714: 204732714
2 CTLA4 CTLA4, 60A-G, 3-PRIME UTR single nucleotide variant risk factor

Expression for Celiac Disease 3

Search GEO for disease gene expression data for Celiac Disease 3.

Pathways for Celiac Disease 3

GO Terms for Celiac Disease 3

Sources for Celiac Disease 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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