MCID: CLL001
MIFTS: 45

Cellular Schwannoma malady

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Summaries for Cellular Schwannoma

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Disease Ontology:8 A neurilemmoma with a predominantly cellular growth but no verocay bodies.

MalaCards based summary: Cellular Schwannoma, also known as cellular neurinoma, is related to malignant peripheral nerve sheath tumor and perineurioma. An important gene associated with Cellular Schwannoma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Nuclear signaling by ERBB4 and Ca, cAMP and Lipid Signaling. The compounds olopatadine and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and trigeminal ganglion, and related mouse phenotypes are vision/eye and normal.

Aliases & Classifications for Cellular Schwannoma

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Cellular Schwannoma, Aliases & Descriptions:

Name: Cellular Schwannoma 8 62
 
Cellular Neurinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3196
NCIt39 C4724

Related Diseases for Cellular Schwannoma

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Diseases related to Cellular Schwannoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1malignant peripheral nerve sheath tumor30.5NF1
2perineurioma30.4VIM, S100B
3neurilemmoma30.2NF1, NF2, GFAP
4neurofibromatosis30.1NF1, NF2
5sarcoma29.6VIM, S100A1, S100B, NF2, NF1
6neurofibroma29.3VIM, S100A1, S100B, NF2, NF1
7spinal cord ependymoma10.4NF2
8subependymal giant cell astrocytoma10.4GFAP
9giant cell glioblastoma10.4GFAP
10secretory meningioma10.4VIM
11rosai-dorfman disease10.4S100B
12mixed glioma10.4GFAP
13langerhans-cell histiocytosis10.2S100A1, S100B
14cutaneous fibrous histiocytoma10.2S100A1, S100B
15fibrous meningioma10.2S100B, NF2
16back pain10.2
17angiomyolipoma10.2VIM, S100A1
18tanycytic ependymoma10.2GFAP, NF2
19malignant ependymoma10.2GFAP, NF2
20fibroma10.2VIM, S100A1
21spindle cell sarcoma10.2VIM, S100B
22fibromatosis10.2S100A1, VIM
23abrikosov's tumor10.2VIM, S100A1
24fibrous histiocytoma10.2VIM, S100B
25rhabdoid meningioma10.2GFAP, VIM
26myxopapillary ependymoma10.2GFAP, S100B
27astroblastoma10.2GFAP, VIM
28papillary ependymoma10.2GFAP, S100B
29choroid plexus carcinoma10.2GFAP, S100B
30sex cord-gonadal stromal tumor10.2S100B, VIM
31choroid plexus papilloma10.1GFAP, S100B
32gemistocytic astrocytoma10.1GFAP, S100B
33cataract10.1NF2
34pineocytoma10.1GFAP, S100B
35oxyphilic adenoma10.1S100A1, VIM
36giant cell tumor10.1VIM, S100B
37hemangioblastoma10.1GFAP, S100B
38renal clear cell carcinoma10.1S100A1, VIM
39nervous system cancer10.1NF2, NF1
40neurofibrosarcoma10.1NF2, NF1
41ganglioglioma10.1GFAP, S100B
42acoustic neuroma10.1NF2, NF1
43sinusitis10.1
44plexiform neurofibroma10.1
45xerophthalmia10.1
46petrositis10.1
47ovarian cyst10.1
48benign schwannoma10.1
49malignant mesothelioma10.1VIM, S100A1, NF2
50ganglioneuroma10.0GFAP, S100B

Graphical network of the top 20 diseases related to Cellular Schwannoma:



Diseases related to cellular schwannoma

Symptoms for Cellular Schwannoma

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Drugs & Therapeutics for Cellular Schwannoma

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Drug clinical trials:

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Genetic Tests for Cellular Schwannoma

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Anatomical Context for Cellular Schwannoma

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MalaCards organs/tissues related to Cellular Schwannoma:

32
Skin, Bone, Trigeminal ganglion

Animal Models for Cellular Schwannoma or affiliated genes

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MGI Mouse Phenotypes related to Cellular Schwannoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.1GFAP, VIM, NF2, NF1
2MP:00028738.1GFAP, S100A1, S100B, NF1
3MP:00053858.0NF1, S100A1, VIM, GFAP
4MP:00053697.9GFAP, VIM, S100A1, NF1
5MP:00053867.2NF1, NF2, S100B, S100A1, VIM, GFAP

Publications for Cellular Schwannoma

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Articles related to Cellular Schwannoma:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
An unusual location for cellular schwannoma. (24718004)
2014
2
Primary pleural hybrid cellular schwannoma/perineurioma: a case report. (24998375)
2014
3
Cellular schwannoma of the retroperitoneum with cystic degeneration, mimicking an ovarian cyst, with CKAE1/AE3 and desmin expression. (25180931)
2014
4
A recurrent cellular schwannoma. (25346907)
2014
5
Atypical presentation of sinonasal cellular schwannoma: a nonsolitary mass with osseous, orbital, and intracranial invasion. (25083375)
2014
6
Infantile cellular schwannoma developing on the skin with atypical clinical features. (25232315)
2014
7
Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report. (24396458)
2014
8
Cellular schwannoma arising from sigmoid mesocolon presenting as torsion. (24349845)
2013
9
Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma. (23709140)
2013
10
A spinal epidural dumbbell cellular schwannoma in an infant. (22325076)
2012
11
Low-back pain as the presenting sign in a patient with a giant, sacral cellular schwannoma: 10-year follow-up. (21214314)
2011
12
Intrapulmonary cellular schwannoma. (20868846)
2010
13
Meningothelial-like whorls in a retroperitoneal cellular schwannoma: potential diagnostic pitfall. (20055955)
2010
14
Trisomy 17 in congenital plexiform (multinodular) cellular schwannoma. (21156251)
2010
15
A huge cystic cellular schwannoma of the intercostal nerve presenting with dyspnea. (19324168)
2009
16
Cellular schwannoma of the abducens nerve: case report and review of the literature. (19200646)
2009
17
Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. (18981849)
2008
18
Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report. (17695403)
2007
19
Unusually large cellular schwannoma of the foot. (15778474)
2005
20
Clonal chromosome abnormalities in a plexiform cellular schwannoma. (15041228)
2004
21
Intrasellar and parasellar cellular schwannoma. (15185261)
2004
22
Small juxtadrenal cellular schwannoma. (14634806)
2004
23
A rare case of cellular schwannoma involving the trigeminal ganglion. (14756445)
2003
24
Cellular schwannoma: report of a case diagnosed intraoperatively with the aid of cytologic imprints. (12889049)
2003
25
Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor. (14508393)
2003
26
Cellular schwannoma: a rare spinal benign nerve-sheath tumor with a pseudosarcomatous appearance: case report. (14762614)
2003
27
Retrobulbar cellular schwannoma. Two cases report and review of the literature. (12812319)
2003
28
A case of cellular schwannoma of the skin presenting as a large ulcerated tumor on the ankle. (11837571)
2002
29
Cellular schwannoma of the paranasal sinuses: initial report of a case. (11987747)
2002
30
Cellular schwannoma in the oral mucosa. (12126009)
2002
31
Cellular schwannoma: a rare presacral tumour. (11939658)
2002
32
Cellular schwannoma of the posterior fossa. (11971068)
2002
33
Cellular schwannoma: a benign neoplasm sometimes overdiagnosed as sarcoma. (11465777)
2001
34
Cellular schwannoma of the mandible: a case report. (11429752)
2001
35
Solitary cellular schwannoma (neurilemmoma) showing malignant changes: evaluation through magnetic resonance imaging (M.R.I.), surgical intervention, and histopathology. (10209928)
1999
36
Cellular schwannoma mimics a sarcoma: an example of a potential pitfall in aspiration cytodiagnosis. (10319235)
1999
37
Retrovesical cellular schwannoma. (9117235)
1997
38
Cellular schwannoma of the bronchus. (8837342)
1996
39
Acoustic cellular schwannoma invading the petrous bone: case report. (8837812)
1996
40
Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. (7850709)
1995
41
Cellular schwannoma. (7978072)
1994
42
Spinal malignant nerve-sheath tumor or cellular schwannoma? A striking difference in prognosis. (8410221)
1993
43
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. (8095064)
1993
44
Cellular schwannoma of the vagina. (1634131)
1992
45
Cellular schwannoma. A clinicopathologic study of 29 cases. (2105560)
1990
46
An unusual case presentation. Cellular schwannoma in pregnancy: an unusual cause of low back pain. (2523473)
1989
47
Primary omental tumor with ultrastructural features of cellular schwannoma and absence of S-100 antigen reactivity. (2602221)
1989
48
Cellular schwannoma of the hand. (2794417)
1989
49
Cellular schwannoma: report of a case with immunohistochemical and electron microscopical study. (3244490)
1988
50
Cellular schwannoma: a distinct pseudosarcomatous entity. (3557324)
1987

Variations for Cellular Schwannoma

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Expression for genes affiliated with Cellular Schwannoma

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Expression patterns in normal tissues for genes affiliated with Cellular Schwannoma

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Pathways for genes affiliated with Cellular Schwannoma

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Pathways related to Cellular Schwannoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, GFAP
29.5S100B, S100A1
39.4NF2, NF1
49.1VIM, GFAP
5
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.1VIM, GFAP
69.1NF2, S100B, GFAP

Compounds for genes affiliated with Cellular Schwannoma

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Compounds related to Cellular Schwannoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1olopatadine44 1110.8S100B, S100A1
22,3-cyclic nucleotide449.8GFAP, S100B
3orcein449.6S100B, VIM
42-methoxyethanol449.5VIM, S100A1
5toluidine449.4VIM, S100A1
6retinaldehyde449.4VIM, GFAP
7silicone449.4GFAP, VIM
8actomyosin449.3S100A1, VIM
9streptozotocin449.1GFAP, VIM
10eosin449.1GFAP, VIM, S100B
11s 100449.1S100B, GFAP, VIM
12reticulin449.1GFAP, S100B, VIM
13mucicarmine449.1VIM, S100A1, S100B
14b 723449.1S100B, S100A1, VIM
15dbc-amp449.1S100B, VIM, GFAP
16cocaine44 1110.1S100B, VIM, GFAP
17bromodeoxyuridine449.0S100B, GFAP, VIM
18choline44 24 1111.0VIM, GFAP, S100B
19formaldehyde44 2410.0S100B, GFAP, VIM
20agar449.0NF2, VIM, GFAP
21cytochalasin d44 6110.0NF2, VIM, NF1
22colchicine44 61 2 28 1113.0NF1, VIM, S100B
23gaba449.0VIM, GFAP, S100B
24dopamine44 28 24 1111.9NF1, GFAP, S100B
25paclitaxel44 50 1110.9GFAP, S100B, VIM
26rapamycin448.8NF1, VIM, NF2
27glutamine448.8GFAP, VIM, S100B
28lactate448.8S100B, VIM, GFAP
29leucine448.7VIM, S100B, GFAP
30hematoxylin448.6VIM, S100B, GFAP, S100A1
31creatinine448.6S100B, VIM, GFAP
32acetylcholine44 50 28 24 1112.6GFAP, S100B, S100A1, VIM
33glycogen44 249.6S100B, GFAP, VIM, S100A1
34iron44 249.6GFAP, VIM, S100A1, S100B
35methionine448.5VIM, GFAP, NF1, S100B
36forskolin44 50 1110.5GFAP, NF1, S100B, VIM
37adenylate448.5VIM, NF1, S100B, GFAP
38cyclic amp44 249.4VIM, GFAP, S100B, NF1
39arginine448.4GFAP, VIM, S100B, NF1
40aspartate448.4GFAP, VIM, S100B
41alanine448.4VIM, GFAP, S100B, NF1
42atp44 289.3NF1, VIM, GFAP, S100B
43tyrosine448.3NF1, GFAP, S100A1, S100B, NF2
44lipid448.3S100B, VIM, GFAP, NF1
45serine448.0NF1, GFAP, NF2, VIM, S100B
46estrogen448.0GFAP, S100A1, NF1, S100B, VIM
47retinoic acid44 249.0GFAP, VIM, S100A1, S100B, NF1
48paraffin447.6VIM, NF2, S100B, S100A1, GFAP, NF1
49progesterone44 28 61 24 1111.6VIM, S100A1, S100B, NF2, NF1, GFAP
50cysteine447.6S100A1, VIM, GFAP, NF2, NF1, S100B

GO Terms for genes affiliated with Cellular Schwannoma

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Cellular components related to Cellular Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1VIM, GFAP
2cytoplasmGO:0057377.3NF1, NF2, S100B, VIM, GFAP

Biological processes related to Cellular Schwannoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:0019539.6NF1, NF2
2negative regulation of MAPK cascadeGO:0434099.5NF2, NF1
3long-term synaptic potentiationGO:0602919.5S100B, GFAP
4negative regulation of cell migrationGO:0303369.4NF1, NF2
5Bergmann glial cell differentiationGO:0600209.3VIM, GFAP
6astrocyte developmentGO:0140029.3VIM, GFAP
7intermediate filament organizationGO:0451099.3VIM, GFAP
8negative regulation of protein kinase activityGO:0064699.1NF1, NF2
9negative regulation of neuron projection developmentGO:0109779.0VIM, GFAP

Molecular functions related to Cellular Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.5S100B, S100A1
2calcium-dependent protein bindingGO:0483069.4S100B, S100A1
3structural constituent of cytoskeletonGO:0052009.1VIM, GFAP
4identical protein bindingGO:0428028.4S100B, S100A1, VIM

Products for genes affiliated with Cellular Schwannoma

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Sources for Cellular Schwannoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet