MCID: CLL001
MIFTS: 39

Cellular Schwannoma

Categories: Cancer diseases

Aliases & Classifications for Cellular Schwannoma

MalaCards integrated aliases for Cellular Schwannoma:

Name: Cellular Schwannoma 12 14 69
Cellular Neurinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3196
NCIt 46 C4724
UMLS 69 C0431124

Summaries for Cellular Schwannoma

Disease Ontology : 12 A neurilemmoma with a predominantly cellular growth but no Verocay bodies.

MalaCards based summary : Cellular Schwannoma, also known as cellular neurinoma, is related to neurofibromatosis, type iv, of riccardi and perineurioma. An important gene associated with Cellular Schwannoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are ERK Signaling and Pathways in cancer. Affiliated tissues include skin, trigeminal ganglion and bone, and related phenotypes are Increased proliferation and behavior/neurological

Related Diseases for Cellular Schwannoma

Diseases related to Cellular Schwannoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 neurofibromatosis, type iv, of riccardi 29.8 NF1 NF2 S100B
2 perineurioma 29.7 DSP S100B SLC2A1
3 neurilemmoma 29.3 NF1 NF2 NGFR S100B SOX10
4 neurofibroma 29.2 CDKN2A NF1 NF2 S100B SOX10
5 malignant peripheral nerve sheath tumor 26.9 CD34 CDKN2A MDM2 NF1 NF2 S100A1
6 neurofibromatosis, familial spinal 10.6 NF1 NF2
7 malignant iris melanoma 10.5 S100A1 S100B
8 eosinophilic variant of chromophobe renal cell carcinoma 10.5 S100A1 SLC2A1
9 neurofibrosarcoma 10.5 NF1 NF2
10 malignant triton tumor 10.4 NF1 S100B
11 malignant peritoneal mesothelioma 10.4 CDKN2A NF2
12 epithelioid malignant peripheral nerve sheath tumor 10.4 NF1 S100B
13 lung meningioma 10.4 CD34 NF2
14 fibrous meningioma 10.4 NF2 S100B
15 epithelioid neurofibroma 10.3 CD34 DSP
16 malignant spindle cell melanoma 10.3 NF1 NGFR SOX10
17 melanotic neurilemmoma 10.3 CD34 NF2
18 optic nerve sheath meningioma 10.3 CDKN2A NF2
19 psammomatous meningioma 10.3 CD34 NF2
20 gliofibroma 10.3 NF1 TP53
21 cerebral convexity meningioma 10.3 NF2 TP53
22 olfactory groove meningioma 10.2 NF2 TP53
23 conventional leiomyosarcoma 10.2 CDKN2A NF1
24 pilocytic astrocytoma 10.2 CDKN2A NF1 SOX10
25 vulvar dystrophy 10.2 CD34 CDKN2A
26 ameloblastic carcinoma 10.2 CDKN2A SLC2A1
27 atrophy of prostate 10.2 SLC2A1 TP53
28 breast angiosarcoma 10.2 CD34 SOX10
29 tetraploidy 10.2 NGFR TP53
30 spinal cancer 10.1 NF2 TP53
31 brain stem astrocytic neoplasm 10.1 CDKN2A TP53
32 autosomal genetic disease 10.1 NF1 NF2 TP53
33 malignant giant cell tumor 10.1 S100B TP53
34 deep angioma 10.1 CD34 SLC2A1
35 squamous cell carcinoma of the oropharynx 10.1 CDKN2A TP53
36 glomangioma 10.1 CD34 S100A1 SLC2A1
37 spitz nevus 10.1 CDKN2A TP53
38 cellular neurofibroma 10.1 CD34 TP53
39 keratinizing squamous cell carcinoma 10.1 CDKN2A TP53
40 squamous cell carcinoma of the larynx 10.0 CDKN2A TP53
41 meninges sarcoma 10.0 CD34 TP53
42 chordoid glioma 10.0 NF2 S100B TP53
43 bartholin's gland benign neoplasm 10.0 CDKN2A TP53
44 optic nerve glioma 10.0 NF1 S100B TP53
45 sarcomatoid squamous cell skin carcinoma 10.0 CD34 TP53
46 juvenile pilocytic astrocytoma 10.0 CDKN2A NF1 TP53
47 bladder carcinoma in situ 9.9 CDKN2A TP53
48 clear cell ependymoma 9.9 CD34 NF2 TP53
49 infiltrating angiolipoma 9.9 CDKN2A MDM2
50 thyroid lymphoma 9.9 CDKN2A TP53

Graphical network of the top 20 diseases related to Cellular Schwannoma:



Diseases related to Cellular Schwannoma

Symptoms & Phenotypes for Cellular Schwannoma

GenomeRNAi Phenotypes related to Cellular Schwannoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 TP53

MGI Mouse Phenotypes related to Cellular Schwannoma:

43 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.39 CDKN2A MDM2 CHD4 SLC2A1 NF1 NGFR
2 cellular MP:0005384 10.38 CHD4 DSP CD34 CDKN2A MDM2 SLC2A1
3 growth/size/body region MP:0005378 10.29 CHD4 DSP CDKN2A MDM2 NGFR NF1
4 embryo MP:0005380 10.28 NF1 DSP CDKN2A MDM2 CHD4 SLC2A1
5 homeostasis/metabolism MP:0005376 10.27 CD34 CDKN2A MDM2 NGFR NF1 S100A1
6 mortality/aging MP:0010768 10.21 CHD4 DSP CDKN2A MDM2 NF2 NGFR
7 integument MP:0010771 10.2 NF1 CD34 DSP CDKN2A MDM2 NGFR
8 immune system MP:0005387 10.18 CHD4 CD34 CDKN2A MDM2 NF2 NGFR
9 digestive/alimentary MP:0005381 10.15 DSP CDKN2A MDM2 NGFR NF1 TP53
10 endocrine/exocrine gland MP:0005379 10.13 MDM2 CHD4 CDKN2A NF2 NF1 SOX2
11 craniofacial MP:0005382 10.1 DSP MDM2 NF2 NGFR NF1 SOX2
12 nervous system MP:0003631 10.06 DSP CDKN2A MDM2 NGFR NF1 NF2
13 neoplasm MP:0002006 10.02 CD34 CDKN2A MDM2 NF1 NF2 SOX10
14 muscle MP:0005369 10.01 DSP CDKN2A MDM2 NGFR NF1 S100A1
15 normal MP:0002873 9.86 MDM2 S100B NGFR NF1 S100A1 SOX2
16 pigmentation MP:0001186 9.7 CDKN2A MDM2 NF1 SOX10 SUZ12 TP53
17 respiratory system MP:0005388 9.56 CDKN2A NGFR NF1 S100A1 NF2 TP53
18 skeleton MP:0005390 9.23 MDM2 CDKN2A NF2 NGFR NF1 SOX2

Drugs & Therapeutics for Cellular Schwannoma

Search Clinical Trials , NIH Clinical Center for Cellular Schwannoma

Genetic Tests for Cellular Schwannoma

Anatomical Context for Cellular Schwannoma

MalaCards organs/tissues related to Cellular Schwannoma:

38
Skin, Trigeminal Ganglion, Bone

Publications for Cellular Schwannoma

Articles related to Cellular Schwannoma:

(show top 50) (show all 62)
# Title Authors Year
1
CHD4 as a Potential Biomarker in Differentiating Between Cellular Schwannoma and Malignant Peripheral Nerve Sheath Tumor. ( 28549031 )
2017
2
Infantile cellular schwannoma developing on the skin with atypical clinical features. ( 25232315 )
2014
3
Cellular schwannoma of the retroperitoneum with cystic degeneration, mimicking an ovarian cyst, with CKAE1/AE3 and desmin expression. ( 25180931 )
2014
4
Spontaneous acute hemorrhage of intraspinal canal cellular schwannoma with paraplegia: A case report. ( 25488387 )
2014
5
Primary pleural hybrid cellular schwannoma/perineurioma: a case report. ( 24998375 )
2014
6
Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report. ( 24396458 )
2014
7
A recurrent cellular schwannoma. ( 25346907 )
2014
8
An unusual location for cellular schwannoma. ( 24718004 )
2014
9
Atypical presentation of sinonasal cellular schwannoma: a nonsolitary mass with osseous, orbital, and intracranial invasion. ( 25083375 )
2014
10
Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma. ( 23709140 )
2013
11
Cellular schwannoma arising from sigmoid mesocolon presenting as torsion. ( 24349845 )
2013
12
A spinal epidural dumbbell cellular schwannoma in an infant. ( 22325076 )
2012
13
Low-back pain as the presenting sign in a patient with a giant, sacral cellular schwannoma: 10-year follow-up. ( 21214314 )
2011
14
Trisomy 17 in congenital plexiform (multinodular) cellular schwannoma. ( 21156251 )
2010
15
Intrapulmonary cellular schwannoma. ( 20868846 )
2010
16
Meningothelial-like whorls in a retroperitoneal cellular schwannoma: potential diagnostic pitfall. ( 20055955 )
2010
17
Cellular schwannoma of the abducens nerve: case report and review of the literature. ( 19200646 )
2009
18
A huge cystic cellular schwannoma of the intercostal nerve presenting with dyspnea. ( 19324168 )
2009
19
Non-healing ulcer on the great toe due to cellular schwannoma. ( 20055863 )
2009
20
Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. ( 18981849 )
2008
21
Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report. ( 17695403 )
2007
22
A rare case of cellular schwannoma in the pharynx. ( 18306575 )
2007
23
Unusually large cellular schwannoma of the foot. ( 15778474 )
2005
24
Intrasellar and parasellar cellular schwannoma. ( 15185261 )
2004
25
Small juxtadrenal cellular schwannoma. ( 14634806 )
2004
26
Clonal chromosome abnormalities in a plexiform cellular schwannoma. ( 15041228 )
2004
27
Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor. ( 14508393 )
2003
28
Retrobulbar cellular schwannoma. Two cases report and review of the literature. ( 12812319 )
2003
29
Cellular schwannoma: a rare spinal benign nerve-sheath tumor with a pseudosarcomatous appearance: case report. ( 14762614 )
2003
30
A rare case of cellular schwannoma involving the trigeminal ganglion. ( 14756445 )
2003
31
Cellular schwannoma: report of a case diagnosed intraoperatively with the aid of cytologic imprints. ( 12889049 )
2003
32
Cellular schwannoma of the posterior fossa. ( 11971068 )
2002
33
Cellular schwannoma: a rare presacral tumour. ( 11939658 )
2002
34
Cellular schwannoma of the paranasal sinuses: initial report of a case. ( 11987747 )
2002
35
Cellular schwannoma in the oral mucosa. ( 12126009 )
2002
36
A case of cellular schwannoma of the skin presenting as a large ulcerated tumor on the ankle. ( 11837571 )
2002
37
Giant intrasacral cellular schwannoma treated with high sacral amputation. ( 11413442 )
2001
38
Cellular schwannoma: a benign neoplasm sometimes overdiagnosed as sarcoma. ( 11465777 )
2001
39
Cellular schwannoma of the mandible: a case report. ( 11429752 )
2001
40
Solitary cellular schwannoma (neurilemmoma) showing malignant changes: evaluation through magnetic resonance imaging (M.R.I.), surgical intervention, and histopathology. ( 10209928 )
1999
41
Cellular schwannoma mimics a sarcoma: an example of a potential pitfall in aspiration cytodiagnosis. ( 10319235 )
1999
42
Solitary cellular schwannoma presenting with haemothorax. ( 10325881 )
1998
43
Retrovesical cellular schwannoma. ( 9117235 )
1997
44
Acoustic cellular schwannoma invading the petrous bone: case report. ( 8837812 )
1996
45
Cellular schwannoma: a clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. ( 8630970 )
1996
46
Cellular schwannoma of the bronchus. ( 8837342 )
1996
47
Cellular schwannoma of the mandible: a case report with ultrastructural and immunohistochemical observations. ( 8600243 )
1996
48
Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. ( 7850709 )
1995
49
Cellular schwannoma. ( 7978072 )
1994
50
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. ( 8095064 )
1993

Variations for Cellular Schwannoma

Expression for Cellular Schwannoma

Search GEO for disease gene expression data for Cellular Schwannoma.

Pathways for Cellular Schwannoma

GO Terms for Cellular Schwannoma

Cellular components related to Cellular Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.77 CDKN2A CHD4 DSP MDM2 NF1 NF2
2 nucleolus GO:0005730 9.63 CDKN2A MDM2 NF1 NF2 SUZ12 TP53
3 cytoplasm GO:0005737 9.47 CD34 CDKN2A CHD4 DSP MDM2 NF1

Biological processes related to Cellular Schwannoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 CHD4 MDM2 S100A1 SOX2 SUZ12 TP53
2 negative regulation of protein kinase activity GO:0006469 9.7 CDKN2A NF1 NF2
3 cellular response to hypoxia GO:0071456 9.69 MDM2 S100B TP53
4 positive regulation of gene expression GO:0010628 9.65 CD34 CDKN2A MDM2 SOX10 TP53
5 wound healing GO:0042060 9.61 DSP NF1 TP53
6 positive regulation of apoptotic process GO:0043065 9.55 CDKN2A NF1 NGFR S100B TP53
7 positive regulation of protein export from nucleus GO:0046827 9.54 MDM2 TP53
8 Ras protein signal transduction GO:0007265 9.54 CDKN2A NF1 TP53
9 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.49 NGFR SOX2
10 positive regulation of myelination GO:0031643 9.48 S100B SOX10
11 replicative senescence GO:0090399 9.46 CDKN2A TP53
12 amyloid fibril formation GO:1990000 9.4 CDKN2A MDM2
13 cellular response to actinomycin D GO:0072717 8.96 MDM2 TP53
14 negative regulation of cell-matrix adhesion GO:0001953 8.8 CDKN2A NF1 NF2

Molecular functions related to Cellular Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.7 MDM2 S100A1 S100B SLC2A1 SOX10 TFG
2 SUMO transferase activity GO:0019789 9.37 CDKN2A MDM2
3 S100 protein binding GO:0044548 9.32 S100A1 S100B
4 disordered domain specific binding GO:0097718 9.13 CDKN2A MDM2 TP53
5 transcription factor binding GO:0008134 9.02 CD34 CDKN2A CHD4 SOX10 TP53
6 protein binding GO:0005515 10.13 CDKN2A CHD4 DSP MDM2 NF1 NF2

Sources for Cellular Schwannoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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