MCID: CLL001
MIFTS: 36

Cellular Schwannoma malady

Summaries for Cellular Schwannoma

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33MalaCards
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MalaCards: Cellular Schwannoma, also known as cellular neurilemmoma, is related to neurofibromatosis and plexiform schwannoma. An important gene associated with Cellular Schwannoma is S100B (S100 calcium binding protein B), and among its related pathways are Prolactin receptor signaling and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds glutamine and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include skin and trigeminal ganglion, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Cellular Schwannoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

cellular schwannoma 8 61
cellular neurilemmoma 8
cellular neurinoma 8


External Ids:

Disease Ontology8 DOID:3196
NCIt40 C4724

Related Diseases for Cellular Schwannoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cellular Schwannoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis30.0NF1, NF2
2plexiform schwannoma10.3
3benign schwannoma10.3
4back pain10.2
5xerophthalmia10.0
6plexiform neurofibroma10.0
7cellular neurofibroma10.0
8childhood malignant schwannoma10.0
9abducens palsy10.0
10histiocytosis10.0S100B
11malignant peripheral nerve sheath tumor10.0NF1
12giant cell glioblastoma10.0GFAP
13subependymal giant cell astrocytoma10.0GFAP
14rosai-dorfman disease10.0S100B
15gliosarcoma10.0GFAP
16herpes simplex10.0NF2
17mixed glioma10.0GFAP
18anaplastic astrocytoma10.0GFAP
19ganglioneuroblastoma10.0S100B
20osteosarcoma10.0NF2
21oligodendroglioma10.0GFAP
22benign mesothelioma10.0NF2
23benign meningioma10.0NF2
24renal oncocytoma10.0S100A1
25leopard syndrome10.0DSP
26langerhans-cell histiocytosis10.0S100B, S100A1
27clear cell ependymoma10.0VIM
28cutaneous fibrous histiocytoma10.0S100B, S100A1
29rhabdoid tumor10.0VIM
30secretory meningioma10.0VIM
31fibrous meningioma10.0S100B, NF2
32hemangioblastoma10.0GFAP, S100B
33ganglioneuroma10.0S100B, GFAP
34pheochromocytoma10.0NF1
35myxopapillary ependymoma10.0S100B, GFAP
36papillary ependymoma10.0S100B, GFAP
37adenoma10.0S100A1
38choroid plexus carcinoma10.0S100B, GFAP
39tanycytic ependymoma10.0NF2, GFAP
40malignant ependymoma10.0NF2, GFAP
41medulloblastoma10.0GFAP, S100B
42choroid plexus papilloma10.0GFAP, S100B
43gemistocytic astrocytoma10.0GFAP, S100B
44vascular disease10.0GFAP
45pineocytoma10.0S100B, GFAP
46nervous system cancer10.0NF2, NF1
47psoriasis10.0S100A1, NF1
48neurofibrosarcoma10.0NF1, NF2
49acoustic neuroma10.0NF1, NF2
50fibrosarcoma10.0VIM

Graphical network of the top 20 diseases related to Cellular Schwannoma:



Diseases related to cellular schwannoma

Clinical Features for Cellular Schwannoma

Drugs & Therapeutics for Cellular Schwannoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cellular Schwannoma

Drug clinical trials:

Search ClinicalTrials for Cellular Schwannoma

Search NIH Clinical Center for Cellular Schwannoma

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Genetic Tests for Cellular Schwannoma

Anatomical Context for Cellular Schwannoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Cellular Schwannoma:

33
Skin, Trigeminal ganglion

Animal Models for Cellular Schwannoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cellular Schwannoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.3GFAP, NF1, NF2, S100A1, S100B, VIM

Publications for Cellular Schwannoma

Sources:
51PubMed
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Articles related to Cellular Schwannoma:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report. (24396458)
2014
2
Cellular schwannoma arising from sigmoid mesocolon presenting as torsion. (24349845)
2013
3
Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma. (23709140)
2013
4
A spinal epidural dumbbell cellular schwannoma in an infant. (22325076)
2012
5
Low-back pain as the presenting sign in a patient with a giant, sacral cellular schwannoma: 10-year follow-up. (21214314)
2011
6
Intrapulmonary cellular schwannoma. (20868846)
2010
7
Meningothelial-like whorls in a retroperitoneal cellular schwannoma: potential diagnostic pitfall. (20055955)
2010
8
Trisomy 17 in congenital plexiform (multinodular) cellular schwannoma. (21156251)
2010
9
A huge cystic cellular schwannoma of the intercostal nerve presenting with dyspnea. (19324168)
2009
10
Cellular schwannoma of the abducens nerve: case report and review of the literature. (19200646)
2009
11
Non-healing ulcer on the great toe due to cellular schwannoma. (20055863)
2009
12
Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. (18981849)
2008
13
Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report. (17695403)
2007
14
A rare case of cellular schwannoma in the pharynx. (18306575)
2007
15
Unusually large cellular schwannoma of the foot. (15778474)
2005
16
Intrasellar and parasellar cellular schwannoma. (15185261)
2004
17
Small juxtadrenal cellular schwannoma. (14634806)
2004
18
A rare case of cellular schwannoma involving the trigeminal ganglion. (14756445)
2003
19
Cellular schwannoma: report of a case diagnosed intraoperatively with the aid of cytologic imprints. (12889049)
2003
20
Cellular schwannoma: a rare spinal benign nerve-sheath tumor with a pseudosarcomatous appearance: case report. (14762614)
2003
21
Retrobulbar cellular schwannoma. Two cases report and review of the literature. (12812319)
2003
22
Cellular schwannoma of the paranasal sinuses: initial report of a case. (11987747)
2002
23
Cellular schwannoma in the oral mucosa. (12126009)
2002
24
Cellular schwannoma: a rare presacral tumour. (11939658)
2002
25
Cellular schwannoma of the posterior fossa. (11971068)
2002
26
Cellular schwannoma: a benign neoplasm sometimes overdiagnosed as sarcoma. (11465777)
2001
27
Cellular schwannoma of the mandible: a case report. (11429752)
2001
28
Giant intrasacral cellular schwannoma treated with high sacral amputation. (11413442)
2001
29
Intrarenal schwannoma: a report of four cases including three cellular variants. (10955450)
2000
30
Solitary cellular schwannoma (neurilemmoma) showing malignant changes: evaluation through magnetic resonance imaging (M.R.I.), surgical intervention, and histopathology. (10209928)
1999
31
Cellular schwannoma mimics a sarcoma: an example of a potential pitfall in aspiration cytodiagnosis. (10319235)
1999
32
Solitary cellular schwannoma presenting with haemothorax. (10325881)
1998
33
Retrovesical cellular schwannoma. (9117235)
1997
34
Cellular schwannoma of the bronchus. (8837342)
1996
35
Acoustic cellular schwannoma invading the petrous bone: case report. (8837812)
1996
36
Cellular schwannoma of the mandible: a case report with ultrastructural and immunohistochemical observations. (8600243)
1996
37
Cellular schwannoma: a clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. (8630970)
1996
38
Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. (7850709)
1995
39
Cellular schwannoma. (7978072)
1994
40
Spinal malignant nerve-sheath tumor or cellular schwannoma? A striking difference in prognosis. (8410221)
1993
41
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. (8095064)
1993
42
Cellular schwannoma of the vagina. (1634131)
1992
43
Retroperitoneal cellular schwannoma: report of a case diagnosed by the presence of S-100 protein. (1803052)
1991
44
Cellular schwannoma. A clinicopathologic study of 29 cases. (2105560)
1990
45
An unusual case presentation. Cellular schwannoma in pregnancy: an unusual cause of low back pain. (2523473)
1989
46
Primary omental tumor with ultrastructural features of cellular schwannoma and absence of S-100 antigen reactivity. (2602221)
1989
47
Cellular schwannoma of the hand. (2794417)
1989
48
Cellular schwannoma: report of a case with immunohistochemical and electron microscopical study. (3244490)
1988
49
Cellular schwannoma: a distinct pseudosarcomatous entity. (3557324)
1987
50
Cellular schwannoma: a variety of schwannoma sometimes mistaken for a malignant tumor. (7337161)
1981

Genetic Variations for Cellular Schwannoma

Expression for genes affiliated with Cellular Schwannoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cellular Schwannoma

Search GEO for disease gene expression data for Cellular Schwannoma.

Pathways for genes affiliated with Cellular Schwannoma

Sources:
54Reactome, 12EMD Millipore, 4Cell Signaling Technology, 52QIAGEN
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Compounds for genes affiliated with Cellular Schwannoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB, 29IUPHAR
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Compounds related to Cellular Schwannoma according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1glutamine4510.0GFAP
22,3-cyclic nucleotide459.9GFAP, S100B
3olopatadine45 1110.9S100A1, S100B
4orcein459.9S100B, VIM
5retinaldehyde459.7GFAP, VIM
62-methoxyethanol459.6S100A1, VIM
7toluidine459.6VIM, S100A1
8silicone459.6GFAP, VIM
9eosin459.5GFAP, S100B, VIM
10s 100459.5GFAP, S100B, VIM
11reticulin459.5VIM, S100B, GFAP
12actomyosin459.4S100A1, VIM
13dbc-amp459.4GFAP, S100B, VIM
14mucicarmine459.4S100A1, S100B, VIM
15b 723459.4S100A1, S100B, VIM
16cocaine45 1110.4VIM, S100B, GFAP
17bromodeoxyuridine459.4GFAP, S100B, VIM
18choline45 11 2411.3VIM, S100B, GFAP
19formaldehyde45 2410.3GFAP, S100B, VIM
20gaba459.2VIM, S100B, GFAP
21agar459.2GFAP, NF2, VIM
22paclitaxel45 50 1111.2VIM, S100B, GFAP
23streptozotocin459.1GFAP, VIM
24colchicine60 45 2 29 1113.0VIM, S100B, NF1
25cytochalasin d45 6010.0NF1, NF2, VIM
26hematoxylin458.9VIM, S100B, S100A1, GFAP
27acetylcholine45 50 29 11 2412.9VIM, S100B, S100A1, GFAP
28glycogen45 249.9GFAP, S100A1, S100B, VIM
29iron45 249.9VIM, S100B, S100A1, GFAP
30rapamycin458.6VIM, NF2, NF1
31methionine458.6VIM, S100B, NF1, GFAP
32forskolin45 50 1110.6VIM, S100B, NF1, GFAP
33adenylate458.6VIM, S100B, NF1, GFAP
34cyclic amp45 249.6VIM, S100B, NF1, GFAP
35arginine458.5VIM, S100B, NF1, GFAP
36alanine458.4GFAP, NF1, S100B, VIM
37atp45 299.3GFAP, NF1, S100B, VIM
38estrogen458.1VIM, S100B, S100A1, NF1, GFAP
39tyrosine457.8S100B, S100A1, DSP, NF2, NF1, GFAP
40paraffin457.7VIM, S100B, S100A1, NF2, NF1, GFAP
41cysteine457.7VIM, S100B, S100A1, NF2, NF1, GFAP
42serine457.7VIM, S100B, DSP, NF2, NF1, GFAP
43calcium45 50 11 2410.7GFAP, NF1, DSP, S100A1, S100B
44retinoic acid45 248.6VIM, S100B, S100A1, DSP, NF1, GFAP
45progesterone45 60 29 11 2411.2GFAP, VIM, S100B, S100A1, DSP, NF2

GO Terms for genes affiliated with Cellular Schwannoma

Sources:
16Gene Ontology
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Cellular components related to Cellular Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.9GFAP, DSP, VIM

Biological processes related to Cellular Schwannoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:0602919.6GFAP, S100B
2Bergmann glial cell differentiationGO:0600209.6GFAP, VIM
3astrocyte developmentGO:0140029.5VIM, GFAP
4negative regulation of cell-matrix adhesionGO:0019539.4NF1, NF2
5negative regulation of MAPK cascadeGO:0434099.3NF2, NF1
6negative regulation of neuron projection developmentGO:0109779.3GFAP, VIM
7negative regulation of protein kinase activityGO:0064699.2NF1, NF2
8intermediate filament organizationGO:0451099.1GFAP, DSP, VIM
9cellular component disassembly involved in execution phase of apoptosisGO:0069219.0DSP, VIM

Molecular functions related to Cellular Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.3DSP, VIM
2S100 protein bindingGO:0445489.3S100A1, S100B
3structural constituent of cytoskeletonGO:0052008.8GFAP, DSP, VIM

Products for genes affiliated with Cellular Schwannoma

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Sources for Cellular Schwannoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet