MCID: CLL001
MIFTS: 40

Cellular Schwannoma malady

Summaries for Cellular Schwannoma

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32MalaCards
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MalaCards: Cellular Schwannoma, also known as cellular neurilemmoma, is related to neurilemmoma and sarcoma. An important gene associated with Cellular Schwannoma is S100B (S100 calcium binding protein B), and among its related pathways are Prolactin receptor signaling and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds glutamine and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and trigeminal ganglion, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Cellular Schwannoma

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

cellular schwannoma 8 60
cellular neurilemmoma 8
cellular neurinoma 8


External Ids:

Disease Ontology8 DOID:3196
NCIt39 C4724

Related Diseases for Cellular Schwannoma

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17GeneCards, 18GeneDecks
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Diseases related to Cellular Schwannoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1neurilemmoma30.3GFAP, NF1, NF2
2sarcoma30.2VIM, S100B, S100A1, DSP, NF2, NF1
3malignant peripheral nerve sheath tumor30.0NF1
4neurofibromatosis30.0NF1, NF2
5neurofibroma30.0VIM, S100B, S100A1, NF2, NF1
6plexiform schwannoma10.3
7peripheral nerve schwannoma10.2
8xerophthalmia10.0
9plexiform neurofibroma10.0
10cellular neurofibroma10.0
11childhood malignant schwannoma10.0
12petrositis10.0
13histiocytosis10.0S100B
14giant cell glioblastoma10.0GFAP
15subependymal giant cell astrocytoma10.0GFAP
16rosai-dorfman disease10.0S100B
17gliosarcoma10.0GFAP
18herpes simplex10.0NF2
19mixed glioma10.0GFAP
20anaplastic astrocytoma10.0GFAP
21ganglioneuroblastoma10.0S100B
22osteosarcoma10.0NF2
23oligodendroglioma10.0GFAP
24benign mesothelioma10.0NF2
25benign meningioma10.0NF2
26renal oncocytoma10.0S100A1
27leopard syndrome10.0DSP
28langerhans-cell histiocytosis10.0S100B, S100A1
29clear cell ependymoma10.0VIM
30cutaneous fibrous histiocytoma10.0S100B, S100A1
31rhabdoid tumor10.0VIM
32secretory meningioma10.0VIM
33fibrous meningioma10.0S100B, NF2
34hemangioblastoma10.0GFAP, S100B
35ganglioneuroma10.0S100B, GFAP
36pheochromocytoma10.0NF1
37myxopapillary ependymoma10.0S100B, GFAP
38papillary ependymoma10.0S100B, GFAP
39adenoma10.0S100A1
40choroid plexus carcinoma10.0S100B, GFAP
41tanycytic ependymoma10.0NF2, GFAP
42malignant ependymoma10.0NF2, GFAP
43medulloblastoma10.0GFAP, S100B
44choroid plexus papilloma10.0GFAP, S100B
45gemistocytic astrocytoma10.0GFAP, S100B
46vascular disease10.0GFAP
47pineocytoma10.0S100B, GFAP
48nervous system cancer10.0NF2, NF1
49psoriasis10.0S100A1, NF1
50neurofibrosarcoma10.0NF1, NF2

Graphical network of the top 20 diseases related to Cellular Schwannoma:



Diseases related to cellular schwannoma

Clinical Features for Cellular Schwannoma

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Drugs & Therapeutics for Cellular Schwannoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Cellular Schwannoma

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Anatomical Context for Cellular Schwannoma

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32MalaCards
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MalaCards organs/tissues related to Cellular Schwannoma:

32
Bone, Skin, Trigeminal ganglion

Animal Models for Cellular Schwannoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cellular Schwannoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.3GFAP, NF1, NF2, S100A1, S100B, VIM

Publications for Cellular Schwannoma

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50PubMed
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Articles related to Cellular Schwannoma:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report. (24396458)
2014
2
Cellular schwannoma arising from sigmoid mesocolon presenting as torsion. (24349845)
2013
3
Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma. (23709140)
2013
4
Intrapulmonary cellular schwannoma. (20868846)
2010
5
Meningothelial-like whorls in a retroperitoneal cellular schwannoma: potential diagnostic pitfall. (20055955)
2010
6
Trisomy 17 in congenital plexiform (multinodular) cellular schwannoma. (21156251)
2010
7
A huge cystic cellular schwannoma of the intercostal nerve presenting with dyspnea. (19324168)
2009
8
Cellular schwannoma of the abducens nerve: case report and review of the literature. (19200646)
2009
9
Non-healing ulcer on the great toe due to cellular schwannoma. (20055863)
2009
10
Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. (18981849)
2008
11
Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report. (17695403)
2007
12
A rare case of cellular schwannoma in the pharynx. (18306575)
2007
13
Unusually large cellular schwannoma of the foot. (15778474)
2005
14
Clonal chromosome abnormalities in a plexiform cellular schwannoma. (15041228)
2004
15
Small juxtadrenal cellular schwannoma. (14634806)
2004
16
A rare case of cellular schwannoma involving the trigeminal ganglion. (14756445)
2003
17
Cellular schwannoma: report of a case diagnosed intraoperatively with the aid of cytologic imprints. (12889049)
2003
18
Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor. (14508393)
2003
19
Cellular schwannoma: a rare spinal benign nerve-sheath tumor with a pseudosarcomatous appearance: case report. (14762614)
2003
20
Retrobulbar cellular schwannoma. Two cases report and review of the literature. (12812319)
2003
21
A case of cellular schwannoma of the skin presenting as a large ulcerated tumor on the ankle. (11837571)
2002
22
Cellular schwannoma of the paranasal sinuses: initial report of a case. (11987747)
2002
23
Cellular schwannoma in the oral mucosa. (12126009)
2002
24
Cellular schwannoma: a rare presacral tumour. (11939658)
2002
25
Cellular schwannoma of the posterior fossa. (11971068)
2002
26
Cellular schwannoma: a benign neoplasm sometimes overdiagnosed as sarcoma. (11465777)
2001
27
Cellular schwannoma of the mandible: a case report. (11429752)
2001
28
Giant intrasacral cellular schwannoma treated with high sacral amputation. (11413442)
2001
29
Intrarenal schwannoma: a report of four cases including three cellular variants. (10955450)
2000
30
Solitary cellular schwannoma (neurilemmoma) showing malignant changes: evaluation through magnetic resonance imaging (M.R.I.), surgical intervention, and histopathology. (10209928)
1999
31
Cellular schwannoma mimics a sarcoma: an example of a potential pitfall in aspiration cytodiagnosis. (10319235)
1999
32
Retrovesical cellular schwannoma. (9117235)
1997
33
Cellular schwannoma of the bronchus. (8837342)
1996
34
Acoustic cellular schwannoma invading the petrous bone: case report. (8837812)
1996
35
Cellular schwannoma of the mandible: a case report with ultrastructural and immunohistochemical observations. (8600243)
1996
36
Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. (7850709)
1995
37
Cellular schwannoma. (7978072)
1994
38
Spinal malignant nerve-sheath tumor or cellular schwannoma? A striking difference in prognosis. (8410221)
1993
39
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. (8095064)
1993
40
Cellular schwannoma of the vagina. (1634131)
1992
41
Retroperitoneal cellular schwannoma: report of a case diagnosed by the presence of S-100 protein. (1803052)
1991
42
Clonal chromosome abnormalities and in vitro growth characteristics of classical and cellular schwannomas. (1756478)
1991
43
Cellular schwannoma. A clinicopathologic study of 29 cases. (2105560)
1990
44
Cellular schwannoma. A clinicopathologic study of 57 patients and 58 tumors. (2400975)
1990
45
An unusual case presentation. Cellular schwannoma in pregnancy: an unusual cause of low back pain. (2523473)
1989
46
Primary omental tumor with ultrastructural features of cellular schwannoma and absence of S-100 antigen reactivity. (2602221)
1989
47
Cellular schwannoma of the hand. (2794417)
1989
48
Cellular schwannoma: report of a case with immunohistochemical and electron microscopical study. (3244490)
1988
49
Cellular schwannoma: a distinct pseudosarcomatous entity. (3557324)
1987
50
Cellular schwannoma: a variety of schwannoma sometimes mistaken for a malignant tumor. (7337161)
1981

Genetic Variations for Cellular Schwannoma

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Expression for genes affiliated with Cellular Schwannoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cellular Schwannoma

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Pathways for genes affiliated with Cellular Schwannoma

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53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Cellular Schwannoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 28IUPHAR
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Compounds related to Cellular Schwannoma according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1glutamine4410.0GFAP
22,3-cyclic nucleotide449.9GFAP, S100B
3olopatadine44 1110.9S100A1, S100B
4orcein449.9S100B, VIM
5retinaldehyde449.7GFAP, VIM
62-methoxyethanol449.6S100A1, VIM
7toluidine449.6VIM, S100A1
8silicone449.6GFAP, VIM
9eosin449.5GFAP, S100B, VIM
10s 100449.5GFAP, S100B, VIM
11reticulin449.5VIM, S100B, GFAP
12actomyosin449.4S100A1, VIM
13dbc-amp449.4GFAP, S100B, VIM
14mucicarmine449.4S100A1, S100B, VIM
15b 723449.4S100A1, S100B, VIM
16cocaine44 1110.4VIM, S100B, GFAP
17bromodeoxyuridine449.4GFAP, S100B, VIM
18choline44 11 2411.3VIM, S100B, GFAP
19formaldehyde44 2410.3GFAP, S100B, VIM
20gaba449.2VIM, S100B, GFAP
21agar449.2GFAP, NF2, VIM
22paclitaxel44 49 1111.2VIM, S100B, GFAP
23streptozotocin449.1GFAP, VIM
24colchicine59 44 2 28 1113.0VIM, S100B, NF1
25cytochalasin d44 5910.0NF1, NF2, VIM
26hematoxylin448.9VIM, S100B, S100A1, GFAP
27acetylcholine44 49 28 11 2412.9VIM, S100B, S100A1, GFAP
28glycogen44 249.9GFAP, S100A1, S100B, VIM
29iron44 249.9VIM, S100B, S100A1, GFAP
30rapamycin448.6VIM, NF2, NF1
31methionine448.6VIM, S100B, NF1, GFAP
32forskolin44 49 1110.6VIM, S100B, NF1, GFAP
33adenylate448.6VIM, S100B, NF1, GFAP
34cyclic amp44 249.6VIM, S100B, NF1, GFAP
35arginine448.5VIM, S100B, NF1, GFAP
36alanine448.4GFAP, NF1, S100B, VIM
37atp44 289.3GFAP, NF1, S100B, VIM
38estrogen448.1VIM, S100B, S100A1, NF1, GFAP
39tyrosine447.8S100B, S100A1, DSP, NF2, NF1, GFAP
40paraffin447.7VIM, S100B, S100A1, NF2, NF1, GFAP
41cysteine447.7VIM, S100B, S100A1, NF2, NF1, GFAP
42serine447.7VIM, S100B, DSP, NF2, NF1, GFAP
43calcium44 49 11 2410.7GFAP, NF1, DSP, S100A1, S100B
44retinoic acid44 248.6VIM, S100B, S100A1, DSP, NF1, GFAP
45progesterone44 59 28 11 2411.2GFAP, VIM, S100B, S100A1, DSP, NF2

GO Terms for genes affiliated with Cellular Schwannoma

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16Gene Ontology
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Cellular components related to Cellular Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.9GFAP, DSP, VIM

Biological processes related to Cellular Schwannoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:0602919.6GFAP, S100B
2Bergmann glial cell differentiationGO:0600209.6GFAP, VIM
3astrocyte developmentGO:0140029.5VIM, GFAP
4negative regulation of cell-matrix adhesionGO:0019539.4NF1, NF2
5negative regulation of MAPK cascadeGO:0434099.3NF2, NF1
6negative regulation of neuron projection developmentGO:0109779.3GFAP, VIM
7negative regulation of protein kinase activityGO:0064699.2NF1, NF2
8intermediate filament organizationGO:0451099.1GFAP, DSP, VIM
9cellular component disassembly involved in execution phase of apoptosisGO:0069219.0DSP, VIM

Molecular functions related to Cellular Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.3DSP, VIM
2S100 protein bindingGO:0445489.3S100A1, S100B
3structural constituent of cytoskeletonGO:0052008.8GFAP, DSP, VIM

Products for genes affiliated with Cellular Schwannoma

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Sources for Cellular Schwannoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet