MCID: CLL001
MIFTS: 44

Cellular Schwannoma malady

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Summaries for Cellular Schwannoma

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MalaCards: Cellular Schwannoma, also known as cellular neurilemmoma, is related to neurilemmoma and malignant peripheral nerve sheath tumor. An important gene associated with Cellular Schwannoma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Nuclear signaling by ERBB4 and Ca, cAMP and Lipid Signaling. The compounds olopatadine and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and trigeminal ganglion, and related mouse phenotypes are vision/eye and normal.

Aliases & Classifications for Cellular Schwannoma

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cellular schwannoma 8 62
cellular neurilemmoma 8
cellular neurinoma 8


External Ids:

Disease Ontology8 DOID:3196
NCIt40 C4724

Related Diseases for Cellular Schwannoma

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17GeneCards, 18GeneDecks
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Diseases related to Cellular Schwannoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1neurilemmoma30.4NF1, NF2, GFAP
2malignant peripheral nerve sheath tumor30.2NF1
3sarcoma30.1VIM, S100A1, S100B, NF2, NF1
4neurofibromatosis30.1NF1, NF2
5neurofibroma29.9VIM, S100A1, S100B, NF2, NF1
6back pain10.2
7spinal cord ependymoma10.1NF2
8subependymal giant cell astrocytoma10.1GFAP
9giant cell glioblastoma10.1GFAP
10secretory meningioma10.1VIM
11rosai-dorfman disease10.1S100B
12mixed glioma10.1GFAP
13glomus tumor10.1S100A1, VIM
14langerhans-cell histiocytosis10.1S100A1, S100B
15cutaneous fibrous histiocytoma10.1S100A1, S100B
16plexiform neurofibroma10.1
17petrositis10.1
18xerophthalmia10.1
19sinusitis10.1
20benign schwannoma10.1
21perineurioma10.0S100B, VIM
22fibrous meningioma10.0NF2, S100B
23angiomyolipoma10.0VIM, S100A1
24tanycytic ependymoma10.0GFAP, NF2
25malignant ependymoma10.0GFAP, NF2
26fibroma10.0VIM, S100A1
27spindle cell sarcoma10.0S100B, VIM
28fibromatosis10.0VIM, S100A1
29fibrous histiocytoma10.0VIM, S100B
30rhabdoid meningioma10.0VIM, GFAP
31myxopapillary ependymoma10.0GFAP, S100B
32papillary ependymoma10.0GFAP, S100B
33abrikosov's tumor10.0VIM, S100A1
34astroblastoma10.0VIM, GFAP
35choroid plexus carcinoma10.0S100B, GFAP
36sex cord-gonadal stromal tumor10.0VIM, S100B
37gemistocytic astrocytoma10.0S100B, GFAP
38choroid plexus papilloma10.0S100B, GFAP
39cataract10.0NF2
40pineocytoma10.0S100B, GFAP
41giant cell tumor10.0S100B, VIM
42oxyphilic adenoma10.0VIM, S100A1
43hemangioblastoma10.0S100B, GFAP
44renal clear cell carcinoma10.0S100A1, VIM
45nervous system cancer10.0NF2, NF1
46neurofibrosarcoma10.0NF2, NF1
47ganglioglioma10.0GFAP, S100B
48acoustic neuroma10.0NF2, NF1
49malignant mesothelioma10.0VIM, NF2, S100A1
50benign mesothelioma10.0VIM, S100A1, NF2

Graphical network of the top 20 diseases related to Cellular Schwannoma:



Diseases related to cellular schwannoma

Symptoms for Cellular Schwannoma

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Drugs & Therapeutics for Cellular Schwannoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Cellular Schwannoma

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Anatomical Context for Cellular Schwannoma

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33MalaCards
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MalaCards organs/tissues related to Cellular Schwannoma:

33
Bone, Skin, Trigeminal ganglion

Animal Models for Cellular Schwannoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cellular Schwannoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.1GFAP, VIM, NF2, NF1
2MP:00028738.1GFAP, S100A1, S100B, NF1
3MP:00053858.0NF1, S100A1, VIM, GFAP
4MP:00053697.9GFAP, VIM, S100A1, NF1
5MP:00053867.2NF1, NF2, S100B, S100A1, VIM, GFAP

Publications for Cellular Schwannoma

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52PubMed
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Articles related to Cellular Schwannoma:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report. (24396458)
2014
2
Cellular schwannoma arising from sigmoid mesocolon presenting as torsion. (24349845)
2013
3
Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma. (23709140)
2013
4
A spinal epidural dumbbell cellular schwannoma in an infant. (22325076)
2012
5
Low-back pain as the presenting sign in a patient with a giant, sacral cellular schwannoma: 10-year follow-up. (21214314)
2011
6
Intrapulmonary cellular schwannoma. (20868846)
2010
7
Meningothelial-like whorls in a retroperitoneal cellular schwannoma: potential diagnostic pitfall. (20055955)
2010
8
Trisomy 17 in congenital plexiform (multinodular) cellular schwannoma. (21156251)
2010
9
A huge cystic cellular schwannoma of the intercostal nerve presenting with dyspnea. (19324168)
2009
10
Cellular schwannoma of the abducens nerve: case report and review of the literature. (19200646)
2009
11
Non-healing ulcer on the great toe due to cellular schwannoma. (20055863)
2009
12
Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. (18981849)
2008
13
Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report. (17695403)
2007
14
Unusually large cellular schwannoma of the foot. (15778474)
2005
15
Clonal chromosome abnormalities in a plexiform cellular schwannoma. (15041228)
2004
16
Intrasellar and parasellar cellular schwannoma. (15185261)
2004
17
Small juxtadrenal cellular schwannoma. (14634806)
2004
18
A rare case of cellular schwannoma involving the trigeminal ganglion. (14756445)
2003
19
Cellular schwannoma: report of a case diagnosed intraoperatively with the aid of cytologic imprints. (12889049)
2003
20
Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor. (14508393)
2003
21
Cellular schwannoma: a rare spinal benign nerve-sheath tumor with a pseudosarcomatous appearance: case report. (14762614)
2003
22
Retrobulbar cellular schwannoma. Two cases report and review of the literature. (12812319)
2003
23
A case of cellular schwannoma of the skin presenting as a large ulcerated tumor on the ankle. (11837571)
2002
24
Cellular schwannoma of the paranasal sinuses: initial report of a case. (11987747)
2002
25
Cellular schwannoma in the oral mucosa. (12126009)
2002
26
Cellular schwannoma: a rare presacral tumour. (11939658)
2002
27
Cellular schwannoma of the posterior fossa. (11971068)
2002
28
Cellular schwannoma: a benign neoplasm sometimes overdiagnosed as sarcoma. (11465777)
2001
29
Cellular schwannoma of the mandible: a case report. (11429752)
2001
30
Giant intrasacral cellular schwannoma treated with high sacral amputation. (11413442)
2001
31
Solitary cellular schwannoma (neurilemmoma) showing malignant changes: evaluation through magnetic resonance imaging (M.R.I.), surgical intervention, and histopathology. (10209928)
1999
32
Cellular schwannoma mimics a sarcoma: an example of a potential pitfall in aspiration cytodiagnosis. (10319235)
1999
33
Retrovesical cellular schwannoma. (9117235)
1997
34
Acoustic cellular schwannoma invading the petrous bone: case report. (8837812)
1996
35
Cellular schwannoma of the mandible: a case report with ultrastructural and immunohistochemical observations. (8600243)
1996
36
Cellular schwannoma: a clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. (8630970)
1996
37
Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. (7850709)
1995
38
Cellular schwannoma. (7978072)
1994
39
Spinal malignant nerve-sheath tumor or cellular schwannoma? A striking difference in prognosis. (8410221)
1993
40
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. (8095064)
1993
41
Cellular schwannoma of the vagina. (1634131)
1992
42
Retroperitoneal cellular schwannoma: report of a case diagnosed by the presence of S-100 protein. (1803052)
1991
43
Clonal chromosome abnormalities and in vitro growth characteristics of classical and cellular schwannomas. (1756478)
1991
44
Cellular schwannoma. A clinicopathologic study of 29 cases. (2105560)
1990
45
Cellular schwannoma. A clinicopathologic study of 57 patients and 58 tumors. (2400975)
1990
46
An unusual case presentation. Cellular schwannoma in pregnancy: an unusual cause of low back pain. (2523473)
1989
47
Primary omental tumor with ultrastructural features of cellular schwannoma and absence of S-100 antigen reactivity. (2602221)
1989
48
Cellular schwannoma of the hand. (2794417)
1989
49
Cellular schwannoma: report of a case with immunohistochemical and electron microscopical study. (3244490)
1988
50
Cellular schwannoma: a distinct pseudosarcomatous entity. (3557324)
1987

Variations for Cellular Schwannoma

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Expression for genes affiliated with Cellular Schwannoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cellular Schwannoma

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Pathways for genes affiliated with Cellular Schwannoma

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50PathCards, 55Reactome, 5Cell Signaling Technology, 53QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 60Thomson Reuters
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Pathways related to Cellular Schwannoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, GFAP
29.5S100B, S100A1
39.4NF2, NF1
49.1VIM, GFAP
5
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.1VIM, GFAP
69.1NF2, S100B, GFAP

Compounds for genes affiliated with Cellular Schwannoma

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45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB, 29IUPHAR, 51PharmGKB
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Compounds related to Cellular Schwannoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1olopatadine45 1110.8S100B, S100A1
22,3-cyclic nucleotide459.8GFAP, S100B
3orcein459.6S100B, VIM
42-methoxyethanol459.5S100A1, VIM
5toluidine459.4VIM, S100A1
6retinaldehyde459.4VIM, GFAP
7silicone459.4VIM, GFAP
8actomyosin459.3VIM, S100A1
9streptozotocin459.1GFAP, VIM
10eosin459.1S100B, VIM, GFAP
11s 100459.1GFAP, VIM, S100B
12reticulin459.1S100B, VIM, GFAP
13mucicarmine459.1VIM, S100A1, S100B
14b 723459.1S100B, S100A1, VIM
15dbc-amp459.1S100B, VIM, GFAP
16cocaine45 1110.1GFAP, VIM, S100B
17bromodeoxyuridine459.0S100B, VIM, GFAP
18choline45 24 1111.0S100B, VIM, GFAP
19formaldehyde45 2410.0GFAP, VIM, S100B
20agar459.0NF2, VIM, GFAP
21cytochalasin d45 6110.0NF1, NF2, VIM
22colchicine45 61 3 29 1113.0VIM, S100B, NF1
23gaba459.0GFAP, VIM, S100B
24dopamine45 29 24 1111.9NF1, S100B, GFAP
25paclitaxel45 51 1110.9GFAP, VIM, S100B
26rapamycin458.8NF1, NF2, VIM
27glutamine458.8S100B, VIM, GFAP
28lactate458.8GFAP, VIM, S100B
29leucine458.7GFAP, VIM, S100B
30hematoxylin458.6GFAP, VIM, S100A1, S100B
31creatinine458.6S100B, VIM, GFAP
32acetylcholine45 51 29 24 1112.6GFAP, VIM, S100A1, S100B
33glycogen45 249.6S100B, S100A1, VIM, GFAP
34iron45 249.6GFAP, VIM, S100A1, S100B
35methionine458.5GFAP, VIM, S100B, NF1
36forskolin45 51 1110.5GFAP, VIM, S100B, NF1
37adenylate458.5GFAP, VIM, S100B, NF1
38cyclic amp45 249.4GFAP, VIM, S100B, NF1
39arginine458.4GFAP, VIM, S100B, NF1
40aspartate458.4VIM, S100B, GFAP
41alanine458.4NF1, S100B, VIM, GFAP
42atp45 299.3GFAP, VIM, S100B, NF1
43tyrosine458.3GFAP, S100A1, S100B, NF2, NF1
44lipid458.3NF1, S100B, VIM, GFAP
45serine458.0GFAP, VIM, S100B, NF2, NF1
46estrogen458.0GFAP, VIM, S100A1, S100B, NF1
47retinoic acid45 249.0NF1, S100B, S100A1, VIM, GFAP
48paraffin457.6NF1, NF2, S100B, S100A1, VIM, GFAP
49progesterone45 29 61 24 1111.6GFAP, VIM, S100A1, S100B, NF2, NF1
50cysteine457.6GFAP, VIM, S100A1, S100B, NF2, NF1

GO Terms for genes affiliated with Cellular Schwannoma

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16Gene Ontology
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Cellular components related to Cellular Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1VIM, GFAP
2cytoplasmGO:0057377.3NF1, NF2, S100B, VIM, GFAP

Biological processes related to Cellular Schwannoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:0019539.6NF1, NF2
2negative regulation of MAPK cascadeGO:0434099.5NF2, NF1
3long-term synaptic potentiationGO:0602919.5S100B, GFAP
4negative regulation of cell migrationGO:0303369.4NF1, NF2
5Bergmann glial cell differentiationGO:0600209.3VIM, GFAP
6astrocyte developmentGO:0140029.3VIM, GFAP
7intermediate filament organizationGO:0451099.3VIM, GFAP
8negative regulation of protein kinase activityGO:0064699.1NF1, NF2
9negative regulation of neuron projection developmentGO:0109779.0VIM, GFAP

Molecular functions related to Cellular Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.5S100B, S100A1
2calcium-dependent protein bindingGO:0483069.4S100B, S100A1
3structural constituent of cytoskeletonGO:0052009.1VIM, GFAP
4identical protein bindingGO:0428028.4S100B, S100A1, VIM

Products for genes affiliated with Cellular Schwannoma

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Sources for Cellular Schwannoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet