MCID: CLL003
MIFTS: 50

Cellulitis malady

Skin diseases category

Summaries for Cellulitis

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MedlinePlus:32 Cellulitis is an infection of the skin and deep underlying tissues. group a strep (streptococcal) bacteria are the most common cause. the bacteria enter your body when you get an injury such as a bruise, burn, surgical cut, or wound. symptoms include fever and chills swollen glands or lymph nodes a rash with painful, red, tender skin. the skin may blister and scab over. your health care provider may take a sample or culture from your skin or do a blood test to identify the bacteria causing infection. treatment is with antibiotics. they may be oral in mild cases, or intravenous (through the vein) for more severe cases. nih: national institute of allergy and infectious diseases

MalaCards based summary: Cellulitis is related to orbital cellulitis and endophthalmitis. An important gene associated with Cellulitis is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are African trypanosomiasis and LDL Oxidation in Atherogenesis. The compounds cdp571 and oxatomide have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lymph node, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:9 A skin disease where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

Wikipedia:63 Cellulitis is a bacterial infection involving the skin. It specifically affects the dermis and... more...

Aliases & Classifications for Cellulitis

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Cellulitis, Aliases & Descriptions:

Name: Cellulitis 9 43 32 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Cellulitis

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Diseases related to Cellulitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 351)
idRelated DiseaseScoreTop Affiliating Genes
1orbital cellulitis32.5NT5C2
2endophthalmitis31.0LACTB
3conjunctivitis31.0IGES
4mediastinitis30.9CRP
5sinusitis30.7DEFB4A, IGES, LACTB, IL5
6bacteremia30.7CRP, LACTB
7folliculitis30.7DEFB4A
8dermatitis30.6IL5, ICAM1, IGES
9systemic lupus erythematosus30.6CRP
10osteomyelitis30.5LACTB, CRP
11leishmaniasis30.4IL5
12alopecia areata30.2ICAM1, IL1R1
13spondylarthropathy30.1TNF, CRP
14hypereosinophilic syndrome30.1IGES, IL5
15meningitis30.0CRP, LACTB
16peritonitis30.0CRP, LACTB, TNF
17toxic shock syndrome30.0TNF, LACTB
18vasculitis30.0TNF, ICAM1, CRP
19pyelonephritis29.9LACTB, CRP
20rheumatoid arthritis29.9TNF, ICAM1, IL1R1, CRP
21colitis29.8DEFB4A, IGES, TNF, IL1R1
22arthritis29.8TNF, LACTB, ICAM1, IL1R1, CRP
23eosinophilia29.7IGES, IL5, IL3
24skin disease29.5CAMP, IL5, ICAM1, TNF, DEFB4A
25pneumonia29.4DEFB4A, IGES, TNF, LACTB, ICAM1, IL5
26psoriasis29.4DEFB4A, TNF, ICAM1, IL5, IL1R1, CAMP
27leukemia29.4TNF, LACTB, FLT4, ICAM1, IL3, IL1R1
28tuberculosis29.3DEFB4A, IGES, TNF, LACTB, CAMP, CRP
29dissecting cellulitis of the scalp10.6
30wells syndrome10.6
31erysipelas10.6
32rheumatoid vasculitis10.5ICAM1
33leukostasis10.5ICAM1
34common cold10.5ICAM1
35schnitzler syndrome10.5IL1R1
36muckle-wells syndrome10.5IL1R1
37epidural abscess10.5CRP
38intrinsic asthma10.4IL5
39septic arthritis10.4CRP
40adult-onset still's disease10.4CRP
41eosinophilic gastroenteritis10.4IL5
42keratoconjunctivitis10.4IL5
43pharyngitis10.4LACTB
44exanthem10.4CRP
45influenza10.4
46blindness10.4
47retinoblastoma10.3
48bronchiolitis10.3IL5
49middle ear cholesteatoma10.3DEFB4A, ICAM1
50alcoholic hepatitis10.3TNF, ICAM1

Graphical network of the top 20 diseases related to Cellulitis:



Diseases related to cellulitis

Symptoms for Cellulitis

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Drugs & Therapeutics for Cellulitis

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Drug clinical trials:

Search ClinicalTrials for Cellulitis

Search NIH Clinical Center for Cellulitis

Genetic Tests for Cellulitis

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Anatomical Context for Cellulitis

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MalaCards organs/tissues related to Cellulitis:

31
Skin, Testes, Lymph node, Eye, T cells, Neutrophil, Breast, Bone, Lung, B cells, Brain, Colon, Kidney, Thyroid, Retina, Heart, Liver, Prostate, Myeloid

Animal Models for Cellulitis or affiliated genes

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MGI Mouse Phenotypes related to Cellulitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6TNF, ICAM1, IL5, IL3, IL1R1
2MP:00053978.3CAMP, IL1R1, IL3, IL5, ICAM1, TNF
3MP:00053767.6TNF, FLT4, ICAM1, IL5, IL3, IL1R1
4MP:00053877.5CRP, TNF, FLT4, ICAM1, IL5, IL3

Publications for Cellulitis

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Articles related to Cellulitis:

(show top 50)    (show all 962)
idTitleAuthorsYear
1
Concurrent Endophthalmitis and Orbital Cellulitis From Metastatic Klebsiella pneumonia Liver Abscess. (25186218)
2014
2
Supermicrosurgical anastomosis of superficial lymphatic vessel to deep lymphatic vessel for a patient with cellulitis-induced chronic localized leg lymphedema. (25197031)
2014
3
Superior ophthalmic vein thrombosis developed after orbital cellulitis. (23448556)
2013
4
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
5
Risk of deep vein thrombosis in patients with cellulitis and erysipelas: a systematic review and meta-analysis. (23948644)
2013
6
Orbital cellulitis caused by community-associated methicillin-resistant Staphylococcus aureus in a previously healthy neonate. (22503797)
2013
7
Oxacillin or cefalotin treatment of hospitalized children with cellulitis. (22274151)
2012
8
Recurrent metastatic breast carcinoma presenting with pansinusitis and choroidal metastases and subsequent bilateral simultaneous orbital cellulitis. (22352825)
2012
9
The hot orbit: orbital cellulitis. (22346113)
2012
10
Eosinophilic cellulitis (Wells syndrome) in a pediatric patient: a case report and review of the literature. (22611749)
2012
11
Identification of Legionella feeleii cellulitis. (21192884)
2011
12
Emphysematous cellulitis of the left thigh caused by sigmoid diverticulum perforation. (21780564)
2011
13
Decreased antibiotic utilization after implementation of a guideline for inpatient cellulitis and cutaneous abscess. (21357799)
2011
14
Number of flocks on the same litter and carcase condemnations due to cellulitis, arthritis and contact foot-pad dermatitis in broilers. (21058060)
2010
15
Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis: a case report. (20699010)
2010
16
Risk stratification and outcome of cellulitis admitted to hospital. (20346971)
2010
17
Orbital cellulitis in children-medical treatment versus surgical management. (19839897)
2009
18
Hypertrophic osteoarthropathy masquerading as lower extremity cellulitis and response to bisphosphonates. (19179906)
2009
19
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
20
Vaccination site reaction or bacterial cellulitis? (20357923)
2009
21
Dissecting cellulitis of the scalp treated with rifampicin and isotretinoin: case reports. (18856159)
2008
22
Refractory dissecting cellulitis of the scalp treated with adalimumab. (19112766)
2008
23
Moxifloxacin-associated neutropenia in a cirrhotic elderly woman with lower extremity cellulitis. (18349304)
2008
24
Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis. (17922409)
2007
25
Successful stem cell transplantation without cryopreservation from a microchimeric haploidentical sibling for refractory acute myeloid leukemia complicated with critical thrombophlebitis and cellulitis. (17261507)
2007
26
Eosinophilic cellulitis (Wells' syndrome) in association with angioimmunoblastic lymphadenopathy. (17989892)
2007
27
Orbital cellulitis after faden operation on the medial rectus. (18058359)
2007
28
Preseptal cellulitis caused by community acquired methicillin resistant Staphylococcus aureus (CAMRSA). (18024828)
2007
29
Kingella kingae orbital cellulitis in a 3-year-old. (16244644)
2006
30
Orbital cellulitis following cataract surgery. (16033368)
2005
31
Effect of corticosteroids in the acute management of pediatric orbital cellulitis with subperiosteal abscess. (16234700)
2005
32
Orbital cellulitis, panophthalmitis, and ecthyma gangrenosum in an immunocompromised host with pseudomonas septicemia. (14700664)
2004
33
Retinoblastoma presenting as orbital cellulitis: report of four cases with a review of the literature. (15559956)
2004
34
Orbital cellulitis associated with Toxocara canis in a dog. (14641832)
2003
35
Predictors of a positive duplex scan in patients with a clinical presentation compatible with deep vein thrombosis or cellulitis. (18159459)
2003
36
Periorbital versus orbital cellulitis. (12488668)
2002
37
Nodular presentation of eosinophilic cellulitis (Wells' syndrome). (11722455)
2001
38
E coli panophthalmitis with orbital cellulitis. (9373510)
1997
39
Pediatric management problems: orbital cellulitis. (8700626)
1996
40
Orbital cellulitis in children: clinical analysis of 16 cases. (7572173)
1995
41
Acute orbital cellulitis after peribulbar injection. (8085597)
1994
42
Bipolaris-induced orbital cellulitis. (1287050)
1992
43
Anaerobic orbital cellulitis and septicemia in a dog. (17423898)
1991
44
Streptococcus faecalis orbital cellulitis. (3087259)
1986
45
Eosinophilic cellulitis (Wells' syndrome) (4015127)
1985
46
The role of high resolution computerized tomography and standardized ultrasound in the evaluation of orbital cellulitis. (7087639)
1982
47
Management and complications of bacterial periorbital and orbital cellulitis. (7185014)
1982
48
Primary dacryocystitis causing orbital cellulitis. (7114699)
1982
49
Gas in the orbit associated with orbital cellulitis and paranasal sinusitis. (4694394)
1973
50
Pneumonyssus caninum and orbital cellulitis in the dog. (5816723)
1969

Variations for Cellulitis

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Expression for genes affiliated with Cellulitis

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Search GEO for disease gene expression data for Cellulitis.

Pathways for genes affiliated with Cellulitis

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Pathways related to Cellulitis according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ICAM1, TNF
29.9ICAM1, TNF
39.9ICAM1, TNF
4
Show member pathways
Serotonin Transporter Activity36
9.8TNF, IL1R1
59.8IL5, TNF
69.5TNF, ICAM1, IL1R1
79.5IL1R1, ICAM1, TNF
89.5IL1R1, ICAM1, TNF
9
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.5DEFB4A, TNF, IL1R1
10
Show member pathways
Immune response CD16 signaling in NK cells58
9.4IL3, ICAM1, TNF
11
Show member pathways
9.4FLT4, IL5, IL1R1
12
Show member pathways
thioredoxin pathway36
9.4CRP, ICAM1, TNF
13
Show member pathways
9.3IL1R1, IL3, TNF
14
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.3TNF, IL5, IL3
15
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.3TNF, IL5, IL3
169.3IL3, IL5, TNF
17
Show member pathways
9.2IL1R1, IL3, IL5
18
Show member pathways
9.1TNF, FLT4, IL3, IL1R1
19
Show member pathways
9.0IL3, IL5, ICAM1, TNF
209.0TNF, IL3, IL1R1, CAMP
21
Show member pathways
9.0ICAM1, IL5, IL3, IL1R1
228.9IL1R1, IL3, IL5, TNF
23
Show member pathways
8.7TNF, FLT4, IL5, IL3, IL1R1
24
Show member pathways
8.7TNF, FLT4, IL5, IL3, IL1R1
25
Show member pathways
8.7TNF, FLT4, IL5, IL3, IL1R1
26
Show member pathways
8.7TNF, FLT4, IL5, IL3, IL1R1
27
Show member pathways
8.7IL1R1, IL3, IL5, FLT4, TNF

Compounds for genes affiliated with Cellulitis

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Compounds related to Cellulitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1cdp571439.8TNF, ICAM1, CRP
2oxatomide439.7IL3, ICAM1, IL5
3nedocromil sodium439.7ICAM1, IL5, IL3
4tenidap43 2810.6TNF, IL1R1, CRP
5anakinra43 1210.6CRP, TNF, IL1R1
6azelastine43 1210.6IL3, IL5, ICAM1
7hydroxychloroquine43 1210.6CRP, IL1R1, TNF
8il-12439.6IL5, IL1R1, TNF
9polymyxin b439.6CAMP, TNF, ICAM1
10lipoteichoic acid439.6DEFB4A, CAMP, IL1R1, TNF
11pentoxifylline43 1210.5TNF, ICAM1, IL1R1, CAMP
12as 10143 5910.5IL1R1, IL5, IL3
13adalimumab43 49 1211.5CRP, IL1R1, TNF
14amphotericin b439.5IL5, IL1R1, CRP
15gm-csf43 2810.5IL5, IL3, ICAM1, TNF
16sulfasalazine28 43 49 1212.4TNF, ICAM1, IL1R1, CRP
17n-formylmethionyl-leucylphenylalanine439.4IL5, ICAM1, TNF, IL3
18percoll439.4CAMP, IL5, IL3
19ceftriaxone43 1210.4IL5, CRP, LACTB
20il 10439.3IL5, TNF, IL3, IL1R1
21okt3439.3TNF, CRP, ICAM1
22leukotriene b443 59 2411.3IL3, IL1R1, IL5, TNF
23hydrocortisone43 2 59 1212.2IL5, IL1R1, TNF, IL3
24herbimycin a43 5910.2IL5, TNF, IL3, ICAM1
25prednisolone43 28 1211.1CRP, IL1R1, IL5, TNF
26fmlp439.1IL5, CAMP, IL3, ICAM1, TNF
27pd 98,059439.1ICAM1, DEFB4A, TNF, CAMP, IL3
28methacholine43 49 1211.0IL5, IGES, ICAM1, CRP
29actinomycin d439.0ICAM1, TNF, IL3, IL1R1, CAMP
30neopterin439.0CRP, TNF, IL1R1, ICAM1, IL3
31prostacyclin439.0ICAM1, IL3, CAMP, CRP, TNF
32ionomycin439.0IL5, IL3, CAMP, TNF
33pge2438.9ICAM1, IL1R1, IL5, CAMP, TNF
34n acetylcysteine438.9TNF, CRP, IL3, ICAM1, IL1R1
35ivig438.9TNF, CRP, IL1R1, IL3, IL5
36endotoxin438.8CRP, IL1R1, ICAM1, TNF, DEFB4A, CAMP
37genistein43 28 59 2 24 1213.8CAMP, IL5, ICAM1, TNF, DEFB4A, IL3
38rantes438.8TNF, IL5, DEFB4A, IL1R1, IL3, ICAM1
39sb 20358043 599.7DEFB4A, IL1R1, CRP, TNF, IL5, ICAM1
40ly294002438.7IL3, CRP, TNF, FLT4, ICAM1, IL5
41heparin43 28 24 1211.6IL3, IL1R1, DEFB4A, CAMP, IL5
42cycloheximide438.5ICAM1, IL5, IL1R1, CRP, IL3, TNF
43cyclosporin a43 28 5910.4IL3, IL1R1, IL5, ICAM1, IGES, TNF
44vegf438.4IL5, ICAM1, IL1R1, FLT4, TNF, CAMP
45lactate438.3IL1R1, ICAM1, TNF, IGES, CRP, IL3
46histamine43 28 2410.2CAMP, DEFB4A, IL3, IL5, ICAM1, TNF
47dexamethasone43 49 28 1211.2TNF, FLT4, ICAM1, IL5, IL3, IL1R1
48retinoic acid43 249.2ICAM1, TNF, DEFB4A, IL1R1, IL3, IL5
49thymidine43 249.2TNF, NT5C2, IL5, IL3, IL1R1, CAMP
50tyrosine437.7CAMP, IL1R1, DEFB4A, FLT4, ICAM1, IL5

GO Terms for genes affiliated with Cellulitis

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Cellular components related to Cellulitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5CRP, IL3, IL5, ICAM1, TNF
2extracellular regionGO:00055767.5CRP, DEFB4A, TNF, FLT4, IL5, IL3

Biological processes related to Cellulitis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of podosome assemblyGO:00718039.9IL5, TNF
2positive regulation of nitric oxide biosynthetic processGO:00454299.8ICAM1, TNF
3negative regulation of lipid storageGO:00108889.7TNF, CRP
4positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4IL3, IL5, ICAM1
5defense response to Gram-positive bacteriumGO:00508309.4CRP, TNF
6inflammatory responseGO:00069549.2CRP, IL5, TNF
7immune responseGO:00069559.0DEFB4A, IL5, IL3, IL1R1

Molecular functions related to Cellulitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0IL3, IL5, TNF
2protein bindingGO:00055157.2FLT4, ICAM1, NT5C2, IL5, IL1R1, CAMP

Products for genes affiliated with Cellulitis

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Sources for Cellulitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet