MCID: CLL003
MIFTS: 56

Cellulitis malady

Skin diseases category

Summaries for Cellulitis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cellulitis is an infection of the skin and deep underlying tissues. group a strep (streptococcal) bacteria are the most common cause. the bacteria enter your body when you get an injury such as a bruise, burn, surgical cut, or wound. symptoms include fever and chills swollen glands or lymph nodes a rash with painful, red, tender skin. the skin may blister and scab over. your health care provider may take a sample or culture from your skin or do a blood test to identify the bacteria causing infection. treatment is with antibiotics. they may be oral in mild cases, or intravenous (through the vein) for more severe cases. nih: national institute of allergy and infectious diseases

MalaCards: Cellulitis is related to orbital cellulitis and dermatitis. An important gene associated with Cellulitis is BIN1 (bridging integrator 1), and among its related pathways are LDL Oxidation in Atherogenesis and Spinal Cord Injury. The compounds estrogen and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lymph node, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

Wikipedia:63 Cellulitis is a diffuse inflammation of connective tissue, caused by bacteria, with severe inflammation... more...

Aliases & Classifications for Cellulitis

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8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Cellulitis

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17GeneCards, 18GeneDecks
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Diseases related to Cellulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1orbital cellulitis31.6NT5C2
2dermatitis30.3ICAM1
3pneumonia30.1ICAM1, TNF, DEFB4A, C5AR1
4leukemia30.1C5AR1, IL1R1, CDX2, FLT4, TNF, ICAM1
5arthritis30.1C5AR1, IL1R1, TNF, ICAM1
6neutropenia30.0C5AR1
7adenocarcinoma30.0CDX2, CHKA, FLT4
8peritonitis29.8C5AR1, TNF
9psoriasis29.8CAMP, ICAM1, TNF, DEFB4A, IL1R1
10systemic lupus erythematosus29.8C5AR1, IL1R1, TNF, ICAM1
11lung cancer29.6SLC5A7
12bacterial vaginosis29.6IL1R1
13herpes simplex29.6CAMP, CDX2
14vasculitis29.6ICAM1, TNF
15sarcoidosis29.6ICAM1, TNF, DEFB4A
16alopecia areata29.6IL1R1, ICAM1
17skin disease29.6DEFB4A, TNF, ICAM1, CAMP
18squamous cell carcinoma29.6IL1R1, CDX2, CHKA, DEFB4A, FLT4, CAMP
19breast cancer29.6CAMP, FLT4, CHKA, CDX2, INPPL1, IL1R1
20erysipelas10.5
21influenza10.3
22retinoblastoma10.3
23endophthalmitis10.3
24cavernous sinus thrombosis10.2
25dissecting cellulitis of the scalp10.2
26dacryocystitis10.2
27retinitis10.2
28wells syndrome10.2
29tinea unguium10.2
30orbit lymphoma10.2
31cryptococcosis10.2
32cataract10.2
33hidradenitis10.2
34myositis10.2
35orbital disease10.2
36strabismus10.2
37tinea capitis10.2
38choroiditis10.1
39panophthalmitis10.1
40acute leukemia10.1
41acne10.1
42conjunctivitis10.1
43central retinal artery occlusion10.1
44hidradenitis suppurativa10.1
45ecthyma10.1
46ethmoid sinusitis10.1
47fasciitis10.1
48frontal sinusitis10.1
49mediastinitis10.1
50melanoma10.1

Graphical network of the top 20 diseases related to Cellulitis:



Diseases related to cellulitis

Clinical Features for Cellulitis

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Drugs & Therapeutics for Cellulitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Cellulitis

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Anatomical Context for Cellulitis

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32MalaCards
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MalaCards organs/tissues related to Cellulitis:

32
Skin, Testes, Lymph node, Eye, T cells, Breast, Bone, Lung, B cells, Thyroid, Brain, Colon, Kidney, Retina, Myeloid, Heart, Liver, Prostate

Animal Models for Cellulitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cellulitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.7TICAM1, ICAM1, TNF, CDX2, IL1R1, BIN1
2MP:00053709.7TNF, FLT4, PRKAB2, CHKA, IL1R1, TICAM1
3MP:00053879.1TICAM1, CAMP, ICAM1, TNF, FLT4, IL1R1
4MP:00053768.9PRKAB2, FLT4, TNF, ICAM1, TICAM1, CHKA
5MP:00107688.9RFK, TICAM1, CAMP, ICAM1, TNF, FLT4

Publications for Cellulitis

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50PubMed
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Articles related to Cellulitis:

(show top 50)    (show all 913)
idTitleAuthorsYear
1
Retinoblastoma presenting with orbital cellulitis. (23791410)
2013
2
Cuterebral ophthalmomyiasis externa presenting as preseptal cellulitis. (23638239)
2013
3
Genotypes and pathogenicity of cellulitis isolates reveal traits that modulate APEC virulence. (23977279)
2013
4
Are two penicillins better than one? A systematic review of oral flucloxacillin and penicillin V versus oral flucloxacillin alone for the emergency department treatment of cellulitis. (23542420)
2013
5
An unusual case of orbital cellulitis due to Panton Valentine Leucocidine producing Staphylococcus aureus. (23099918)
2013
6
Bullous eosinophilic cellulitis in a child treated with dapsone. (22958063)
2013
7
Blindness resulting from orbital cellulitis following rhinoplasty. (23402932)
2013
8
Factors influencing the occurrence of pelvic cellulitis in women undergoing laparoscopic-assisted vaginal hysterectomy. (23040949)
2012
9
Cellulitis--epidemiological and clinical characteristics. (22937694)
2012
10
Intramuscular metastasis of malignant melanoma mimicking leg cellulitis. (22133451)
2012
11
An evidence-based approach to diagnosis and management of cellulitis. (22585250)
2012
12
Co-trimoxazole is useful in community acquired MRSA cellulitis. (22951557)
2012
13
Identification of Legionella feeleii cellulitis. (21192884)
2011
14
Concurrent endophthalmitis and orbital cellulitis in a child with congenital glaucoma and a glaucoma drainage device. (23362400)
2011
15
Recto-femoral fistula presenting as emphysematous cellulitis of the knee: a case report & literature review. (23326693)
2011
16
Pathology in practice. Mycotic dermatitis, cellulitis, and myositis. (22044326)
2011
17
Campylobacter jejuni cellulitis in a patient with pan-hypogammaglobulinaemia. (22714594)
2011
18
Group A streptococcal cellulitis in the early puerperium. (21899183)
2011
19
Successful management of methicillin-resistant Staphylococcus aureus orbital cellulitis after blepharoplasty. (21124103)
2010
20
Relapsing Legionella pneumophila cellulitis: a case report and review of the literature. (20526646)
2010
21
Distinguishing features of preseptal and orbital cellulitis. (20373661)
2010
22
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
23
A case of eosinophilic cellulitis of the hand mimicking bacterial cellulitis. (19457919)
2009
24
Cellulitis due to gas-producing organism with niveau formation. (19878400)
2009
25
The many faces of cellulitis. (19304901)
2009
26
Cellulitis with compartment syndrome as a complication of varicella zoster infection. (18157764)
2008
27
Retrospective study of the clinical features of limb cellulitis in 63 horses. (18296664)
2008
28
Eosinophilic cellulitis (Wells' syndrome) in association with angioimmunoblastic lymphadenopathy. (17989892)
2007
29
Methicillin-resistant Staphylococcus aureus pyomyositis presenting with cellulitis-like symptoms. (17425650)
2007
30
Recurrence of lymphoedema-associated cellulitis (erysipelas) under prophylactic antibiotherapy: a retrospective cohort study. (16898904)
2006
31
Disseminated cutaneous nocardiosis mimicking cellulitis and erythema nodosum. (17459299)
2006
32
Toxic scarlet fever complicating cellulitis: early clinical diagnosis is crucial to prevent a fatal outcome. (15164635)
2004
33
Inflammatory tinea pedis/manuum masquerading as bacterial cellulitis. (12413346)
2002
34
Orbital cellulitis with gas. (12045964)
2000
35
Wells' syndrome (eosinophilic cellulitis): correlation between clinical activity, eosinophil levels, eosinophil cation protein and interleukin-5. (10215782)
1999
36
Nasolacrimal duct obstruction and orbital cellulitis associated with chronic intranasal cocaine abuse. (10604666)
1999
37
Clinical practice guidelines for the management of orbital cellulitis. (9559505)
1998
38
Folliculotropic mycosis fungoides with large-cell transformation presenting as dissecting cellulitis of the scalp. (9085153)
1997
39
Neutrophilic eccrine hidradenitis simulating orbital cellulitis. (7980136)
1994
40
Orbital cellulitis after retrobulbar injection of chlorpromazine. (8216007)
1993
41
Anaerobic orbital cellulitis: a clinical and experimental study. (1808813)
1991
42
CT scanning in orbital cellulitis. (20894690)
1988
43
Computerized tomography in the management of acute orbital cellulitis. (3431804)
1987
44
Ethmoiditis, conjunctivitis, and orbital cellulitis due to enterococcus infection. (6420105)
1984
45
Acute orbital cellulitis: a multidisciplinary emergency. (6578843)
1983
46
Orbital cellulitis of dental origin: differential diagnosis and the use of computed tomography as a diagnostic aid. (6931890)
1980
47
Orbital cellulitis and blindness following a blepharoplasty. (515236)
1979
48
An unusual organism causing orbital cellulitis. (389281)
1979
49
Hypopyon and orbital cellulitis associated with Haemophilus influenzae type B meningitis. Diagnostic and therapeutic implications. (299978)
1977
50
Orbital cellulitis due to Haemophilus influenzae. (4543999)
1974

Genetic Variations for Cellulitis

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Expression for genes affiliated with Cellulitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cellulitis

Search GEO for disease gene expression data for Cellulitis.

Pathways for genes affiliated with Cellulitis

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51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Cellulitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TNF, ICAM1
210.2IL1R1, TNF, ICAM1
3
Immune response Bacterial infections in normal airways
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10.1TNF, DEFB4A, IL1R1
410.1SLC5A7, IL1R1, TNF
510.1RFK, TNF, ICAM1
610.0IL1R1, TNF, ICAM1, TICAM1

Compounds for genes affiliated with Cellulitis

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cellulitis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8DEFB4A
2cdp5714410.6ICAM1, TNF
3interferon gamma4410.6ICAM1, TNF
4polymyxin b4410.6TNF, ICAM1, CAMP
5sulfasalazine44 28 49 1113.6IL1R1, TNF, ICAM1
6n-tosyl-l-phenylalanine chloromethyl ketone4410.5TNF, ICAM1
7tenidap44 2811.5IL1R1, TNF
8diphenyleneiodonium4410.5IL1R1, TNF, ICAM1
9peptidoglycan44 2811.5TNF, DEFB4A, IL1R1
10anakinra44 1111.5IL1R1, TNF
11pentoxifylline44 1111.5CAMP, ICAM1, TNF, IL1R1
12ccl344 2811.5IL1R1, TNF, ICAM1
13lipoteichoic acid4410.5IL1R1, DEFB4A, TNF, CAMP
14neopterin4410.5IL1R1, TNF, ICAM1
15n-formylmethionyl-leucylphenylalanine4410.5C5AR1, TNF, ICAM1
16hydroxychloroquine44 1111.4IL1R1, TNF
17dexamethasone44 49 28 1113.4CAMP, DEFB4A, CHKA, IL1R1
18fmlp4410.4C5AR1, TNF, ICAM1, CAMP
19prostacyclin4410.4CAMP, ICAM1, TNF, C5AR1
20efalizumab44 1111.4ICAM1, TNF
21prostaglandin4410.4C5AR1, IL1R1, TNF, CAMP
22nacl4410.3C5AR1, IL1R1, DEFB4A, CAMP
23hbd24410.3CAMP, DEFB4A
24rantes4410.3ICAM1, TNF, DEFB4A, IL1R1, C5AR1
25histamine44 28 2412.3ICAM1, TNF, DEFB4A, C5AR1, CAMP
26oxygen44 2411.3ICAM1, TNF, FLT4, C5AR1
27pd 98,0594410.3CAMP, ICAM1, TNF, DEFB4A, C5AR1
28sb 20358044 5911.3ICAM1, TNF, DEFB4A, IL1R1, C5AR1
29genistein44 28 59 2 11 2415.3CAMP, ICAM1, TNF, DEFB4A, CHKA
30n acetylcysteine4410.3ICAM1, TNF, CHKA, IL1R1
31paraffin4410.3FLT4, DEFB4A, CHKA, CDX2, IL1R1
32leukotriene b444 59 2412.2TNF, IL1R1, C5AR1
33endotoxin4410.2C5AR1, IL1R1, DEFB4A, TNF, ICAM1, CAMP
34vitamin d4410.2CAMP, CHKA, CDX2, IL1R1, C5AR1
35fibrinogen4410.2ICAM1, TNF, IL1R1, C5AR1
36cellulose4410.2IL1R1, C5AR1
37ulinastatin4410.2ICAM1, TNF
38vegf4410.2CAMP, ICAM1, TNF, FLT4, IL1R1, C5AR1
39progesterone44 59 28 11 2414.1CAMP, DEFB4A, CHKA, CDX2, IL1R1
40retinoic acid44 2411.1IL1R1, CHKA, DEFB4A, FLT4, TNF, ICAM1
41thymidine44 2411.1CAMP, TNF, CHKA, NT5C2, CDX2, INPPL1
42h2o24410.1ICAM1, TNF, CHKA, IL1R1, C5AR1
43lipid449.9CAMP, TNF, DEFB4A, CHKA, INPPL1, IL1R1
44sp 60012544 5910.9ICAM1, TNF, DEFB4A
45steroid449.9IL1R1, CDX2, CHKA, DEFB4A, CAMP
46tyrosine449.8CAMP, ICAM1, FLT4, DEFB4A, CHKA, CDX2

GO Terms for genes affiliated with Cellulitis

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16Gene Ontology
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Cellular components related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic cupGO:00189110.3BIN2, TNF

Biological processes related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of nitric oxide biosynthetic processGO:04542910.2TNF, ICAM1, TICAM1
2positive regulation of NF-kappaB transcription factor activityGO:05109210.2TNF, ICAM1, TICAM1
3positive regulation of chemokine biosynthetic processGO:04508010.2TNF, TICAM1
4positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TNF, FLT4, C5AR1

Molecular functions related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1choline bindingGO:03326510.2SLC5A7, CHKA

Products for genes affiliated with Cellulitis

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Sources for Cellulitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet