MCID: CLL003
MIFTS: 56

Cellulitis malady

Skin diseases category

Summaries for Cellulitis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cellulitis is an infection of the skin and deep underlying tissues. group a strep (streptococcal) bacteria are the most common cause. the bacteria enter your body when you get an injury such as a bruise, burn, surgical cut, or wound. symptoms include fever and chills swollen glands or lymph nodes a rash with painful, red, tender skin. the skin may blister and scab over. your health care provider may take a sample or culture from your skin or do a blood test to identify the bacteria causing infection. treatment is with antibiotics. they may be oral in mild cases, or intravenous (through the vein) for more severe cases. nih: national institute of allergy and infectious diseases

MalaCards: Cellulitis is related to orbital cellulitis and dermatitis. An important gene associated with Cellulitis is BIN1 (bridging integrator 1), and among its related pathways are LDL Oxidation in Atherogenesis and Spinal Cord Injury. The compounds estrogen and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lymph node, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

Wikipedia:63 Cellulitis is a diffuse inflammation of connective tissue, caused by bacteria, with severe inflammation... more...

Aliases & Classifications for Cellulitis

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8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Cellulitis

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17GeneCards, 18GeneDecks
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Diseases related to Cellulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1orbital cellulitis31.6NT5C2
2dermatitis30.3ICAM1
3pneumonia30.1ICAM1, TNF, DEFB4A, C5AR1
4leukemia30.1C5AR1, IL1R1, CDX2, FLT4, TNF, ICAM1
5arthritis30.1C5AR1, IL1R1, TNF, ICAM1
6neutropenia30.0C5AR1
7adenocarcinoma30.0CDX2, CHKA, FLT4
8peritonitis29.8C5AR1, TNF
9psoriasis29.8CAMP, ICAM1, TNF, DEFB4A, IL1R1
10systemic lupus erythematosus29.8C5AR1, IL1R1, TNF, ICAM1
11lung cancer29.6SLC5A7
12bacterial vaginosis29.6IL1R1
13herpes simplex29.6CAMP, CDX2
14vasculitis29.6ICAM1, TNF
15sarcoidosis29.6ICAM1, TNF, DEFB4A
16alopecia areata29.6IL1R1, ICAM1
17skin disease29.6DEFB4A, TNF, ICAM1, CAMP
18squamous cell carcinoma29.6IL1R1, CDX2, CHKA, DEFB4A, FLT4, CAMP
19breast cancer29.6CAMP, FLT4, CHKA, CDX2, INPPL1, IL1R1
20erysipelas10.5
21influenza10.3
22retinoblastoma10.3
23endophthalmitis10.3
24cavernous sinus thrombosis10.2
25dissecting cellulitis of the scalp10.2
26dacryocystitis10.2
27retinitis10.2
28wells syndrome10.2
29tinea unguium10.2
30orbit lymphoma10.2
31cryptococcosis10.2
32cataract10.2
33hidradenitis10.2
34myositis10.2
35orbital disease10.2
36strabismus10.2
37tinea capitis10.2
38choroiditis10.1
39panophthalmitis10.1
40acute leukemia10.1
41acne10.1
42conjunctivitis10.1
43central retinal artery occlusion10.1
44hidradenitis suppurativa10.1
45ecthyma10.1
46ethmoid sinusitis10.1
47fasciitis10.1
48frontal sinusitis10.1
49mediastinitis10.1
50melanoma10.1

Graphical network of the top 20 diseases related to Cellulitis:



Diseases related to cellulitis

Clinical Features for Cellulitis

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Drugs & Therapeutics for Cellulitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Cellulitis

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Anatomical Context for Cellulitis

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32MalaCards
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MalaCards organs/tissues related to Cellulitis:

32
Skin, Testes, Lymph node, Eye, T cells, Breast, Lung, Bone, B cells, Brain, Kidney, Thyroid, Colon, Heart, Prostate, Myeloid, Liver, Retina

Animal Models for Cellulitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cellulitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.7TICAM1, ICAM1, TNF, CDX2, IL1R1, BIN1
2MP:00053709.7TNF, FLT4, PRKAB2, CHKA, IL1R1, TICAM1
3MP:00053879.1TICAM1, CAMP, ICAM1, TNF, FLT4, IL1R1
4MP:00053768.9PRKAB2, FLT4, TNF, ICAM1, TICAM1, CHKA
5MP:00107688.9RFK, TICAM1, CAMP, ICAM1, TNF, FLT4

Publications for Cellulitis

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50PubMed
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Articles related to Cellulitis:

(show top 50)    (show all 913)
idTitleAuthorsYear
1
Internal medicine flashcards: All that is red is not cellulitis. (24393443)
2014
2
Concurrent hidradenitis suppurativa, inflammatory acne, dissecting cellulitis of the scalp, and pyoderma gangrenosum in a 16-year-old boy. (24118007)
2014
3
Cutaneous reactive angiomatosis with combined histological pattern mimicking a cellulitis. (24107746)
2013
4
Mental disorder as a risk factor for dog bites and post-bite cellulitis. (21529803)
2012
5
Orbital and preseptal cellulitis: a 10-year survey of hospitalized patients in a tertiary eye hospital in Iran. (22552581)
2012
6
Who should manage acute periorbital cellulitis in children? (22572409)
2012
7
Hypertrophic osteodystrophy preceding canine juvenile cellulitis in an Australian shepherd puppy. (21731101)
2011
8
Bullous cellulitis in cirrhotic patients--a rare but life-threatening infection caused by non-O1, non-O139 Vibrio cholerae bacteraemia. (21292862)
2011
9
Excisional surgery (scalpectomy) for dissecting cellulitis of the scalp. (21631639)
2011
10
Palisaded neutrophilic granulomatous dermatitis caused by cellulitis in a patient with systemic lupus erythematosus. (22098012)
2011
11
Periorbital mass with cellulitis caused by dirofilaria. (22120811)
2011
12
Role of Clostridium perfringens and Clostridium septicum in causing turkey cellulitis. (20608521)
2010
13
Staphylococcus aureus is the most common identified cause of cellulitis: a systematic review. (19646308)
2010
14
Factors predisposing to acute and recurrent bacterial non-necrotizing cellulitis in hospitalized patients: a prospective case-control study. (19694769)
2010
15
Buttock cellulitis as a presentation of psoas abscess: a clinical reminder. (21597579)
2010
16
Ambient ozone and emergency department visits for cellulitis. (21139878)
2010
17
Omphalith-associated relapsing umbilical cellulitis: recurrent omphalitis secondary to a hair-containing belly button bezoar. (21140929)
2010
18
Hypertrophic osteoarthropathy masquerading as lower extremity cellulitis and response to bisphosphonates. (19179906)
2009
19
Recurrent cellulitis in a case of Aagenaes syndrome. (19498211)
2009
20
The efficacy and safety of daptomycin vs. vancomycin for the treatment of cellulitis and erysipelas. (19222623)
2009
21
A child with bilateral orbital cellulitis one day after strabismus surgery. (19840730)
2009
22
A fatal case of Vibrio vulnificus cellulitis with septicaemia. (20527281)
2009
23
Acute hypocomplementemic post-infectious glomerulonephritis as a complication of sinus-related orbital cellulitis: case report. (18797672)
2008
24
A Case of Helicobacter cinaedi Bacteraemia in a Previously Healthy Person with Cellulitis. (19088908)
2008
25
Clinical analysis of computed tomography-staged orbital cellulitis in children. (18087633)
2007
26
Management of fulminant dissecting cellulitis of the scalp in the pediatric population: Case report and literature review. (19554179)
2007
27
Cellulitis as a postprocedural complication of topical 5-aminolevulinic acid photodynamic therapy in the treatment of actinic keratosis. (17679192)
2007
28
Kingella kingae orbital cellulitis in a 3-year-old. (16244644)
2006
29
Late onset lamellar keratitis and epithelial ingrowth following orbital cellulitis. (16523841)
2006
30
Vulvovaginitis and perineal cellulitis due to group a streptococcus in an adult woman. (15967936)
2005
31
Orbital cellulitis: a rare complication after orbital blowout fracture. (16157384)
2005
32
Mucocutaneous leishmaniasis presenting as facial cellulitis. (16175986)
2005
33
Orbital cellulitis and abscess secondary to dacryocystitis. (12149070)
2002
34
Sinusitis as a cause of orbital cellulitis. (10793834)
1999
35
Giant cell arteritis, polymyalgia rheumatica, and viral hypotheses: a multicenter, prospective case-control study. Groupe de Recherche sur l'ArtAcrite A Cellules GAcantes. (9972970)
1999
36
Meningococcal cellulitis and sialadenitis. (9521374)
1998
37
Endophthalmitis and orbital cellulitis after radial keratotomy. (9098294)
1995
38
Acute orbital cellulitis after peribulbar injection. (8085597)
1994
39
Extensive cellulitis with septic shock caused by Vibrio vulnificus infection--a case report with review of literature. (1791352)
1991
40
Clinical management of orbital cellulitis in children. (2328431)
1990
41
Endogenous orbital cellulitis and endogenous endophthalmitis in subacute bacterial endocarditis. (2787962)
1989
42
Eosinophilic cellulitis (Wells' syndrome): ultrastructural study of a case with circulating immune complexes. (2969834)
1988
43
Acute severe irreversible visual loss with sphenoethmoiditis-'posterior' orbital cellulitis. (3827709)
1987
44
Dissecting cellulitis of the scalp. (3513219)
1986
45
Orbital cellulitis and sinusitis caused by group B beta streptococcus in a 3-year-old child. (3884823)
1985
46
Cutaneous Mycobacterium kansasii infection presenting as cellulitis. (6825464)
1983
47
Bilateral Candida albicans dacryocystitis with facial cellulitis. (7127203)
1982
48
Antibiotics in phlegmonous laryngitis (laryngeal cellulitis). (13209146)
1954
49
Orbital Cellulitis due to Ethmoidal and Frontal Sinus Disease. (19977922)
1914
50
The use of subconjunctival injections of sublimate in cases of orbital cellulitis. (16691980)
1902

Genetic Variations for Cellulitis

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Expression for genes affiliated with Cellulitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cellulitis

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Pathways for genes affiliated with Cellulitis

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51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Cellulitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TNF, ICAM1
210.2IL1R1, TNF, ICAM1
3
Immune response Bacterial infections in normal airways
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10.1TNF, DEFB4A, IL1R1
410.1SLC5A7, IL1R1, TNF
510.1RFK, TNF, ICAM1
610.0IL1R1, TNF, ICAM1, TICAM1

Compounds for genes affiliated with Cellulitis

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cellulitis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8DEFB4A
2cdp5714410.6ICAM1, TNF
3interferon gamma4410.6ICAM1, TNF
4polymyxin b4410.6TNF, ICAM1, CAMP
5sulfasalazine44 28 49 1113.6IL1R1, TNF, ICAM1
6n-tosyl-l-phenylalanine chloromethyl ketone4410.5TNF, ICAM1
7tenidap44 2811.5IL1R1, TNF
8diphenyleneiodonium4410.5IL1R1, TNF, ICAM1
9peptidoglycan44 2811.5TNF, DEFB4A, IL1R1
10anakinra44 1111.5IL1R1, TNF
11pentoxifylline44 1111.5CAMP, ICAM1, TNF, IL1R1
12ccl344 2811.5IL1R1, TNF, ICAM1
13lipoteichoic acid4410.5IL1R1, DEFB4A, TNF, CAMP
14neopterin4410.5IL1R1, TNF, ICAM1
15n-formylmethionyl-leucylphenylalanine4410.5C5AR1, TNF, ICAM1
16hydroxychloroquine44 1111.4IL1R1, TNF
17dexamethasone44 49 28 1113.4CAMP, DEFB4A, CHKA, IL1R1
18fmlp4410.4C5AR1, TNF, ICAM1, CAMP
19prostacyclin4410.4CAMP, ICAM1, TNF, C5AR1
20efalizumab44 1111.4ICAM1, TNF
21prostaglandin4410.4C5AR1, IL1R1, TNF, CAMP
22nacl4410.3C5AR1, IL1R1, DEFB4A, CAMP
23hbd24410.3CAMP, DEFB4A
24rantes4410.3ICAM1, TNF, DEFB4A, IL1R1, C5AR1
25histamine44 28 2412.3ICAM1, TNF, DEFB4A, C5AR1, CAMP
26oxygen44 2411.3ICAM1, TNF, FLT4, C5AR1
27pd 98,0594410.3CAMP, ICAM1, TNF, DEFB4A, C5AR1
28sb 20358044 5911.3ICAM1, TNF, DEFB4A, IL1R1, C5AR1
29genistein44 28 59 2 11 2415.3CAMP, ICAM1, TNF, DEFB4A, CHKA
30n acetylcysteine4410.3ICAM1, TNF, CHKA, IL1R1
31paraffin4410.3FLT4, DEFB4A, CHKA, CDX2, IL1R1
32leukotriene b444 59 2412.2TNF, IL1R1, C5AR1
33endotoxin4410.2C5AR1, IL1R1, DEFB4A, TNF, ICAM1, CAMP
34vitamin d4410.2CAMP, CHKA, CDX2, IL1R1, C5AR1
35fibrinogen4410.2ICAM1, TNF, IL1R1, C5AR1
36cellulose4410.2IL1R1, C5AR1
37ulinastatin4410.2ICAM1, TNF
38vegf4410.2CAMP, ICAM1, TNF, FLT4, IL1R1, C5AR1
39progesterone44 59 28 11 2414.1CAMP, DEFB4A, CHKA, CDX2, IL1R1
40retinoic acid44 2411.1IL1R1, CHKA, DEFB4A, FLT4, TNF, ICAM1
41thymidine44 2411.1CAMP, TNF, CHKA, NT5C2, CDX2, INPPL1
42h2o24410.1ICAM1, TNF, CHKA, IL1R1, C5AR1
43lipid449.9CAMP, TNF, DEFB4A, CHKA, INPPL1, IL1R1
44sp 60012544 5910.9ICAM1, TNF, DEFB4A
45steroid449.9IL1R1, CDX2, CHKA, DEFB4A, CAMP
46tyrosine449.8CAMP, ICAM1, FLT4, DEFB4A, CHKA, CDX2

GO Terms for genes affiliated with Cellulitis

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16Gene Ontology
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Cellular components related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic cupGO:00189110.3BIN2, TNF

Biological processes related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of nitric oxide biosynthetic processGO:04542910.2TNF, ICAM1, TICAM1
2positive regulation of NF-kappaB transcription factor activityGO:05109210.2TNF, ICAM1, TICAM1
3positive regulation of chemokine biosynthetic processGO:04508010.2TNF, TICAM1
4positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TNF, FLT4, C5AR1

Molecular functions related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1choline bindingGO:03326510.2SLC5A7, CHKA

Products for genes affiliated with Cellulitis

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Sources for Cellulitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet