MCID: CLL003
MIFTS: 59

Cellulitis malady

Skin diseases category
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Summaries for Cellulitis

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MedlinePlus:33 Cellulitis is an infection of the skin and deep underlying tissues. group a strep (streptococcal) bacteria are the most common cause. the bacteria enter your body when you get an injury such as a bruise, burn, surgical cut, or wound. symptoms include fever and chills swollen glands or lymph nodes a rash with painful, red, tender skin. the skin may blister and scab over. your health care provider may take a sample or culture from your skin or do a blood test to identify the bacteria causing infection. treatment is with antibiotics. they may be oral in mild cases, or intravenous (through the vein) for more severe cases. nih: national institute of allergy and infectious diseases

MalaCards based summary: Cellulitis is related to orbital cellulitis and endophthalmitis. An important gene associated with Cellulitis is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are African trypanosomiasis and LDL Oxidation in Atherogenesis. The compounds cdp571 and oxatomide have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lymph node, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:8 A skin disease where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

Wikipedia:65 Cellulitis is a bacterial infection involving the skin. It specifically affects the dermis and... more...

Aliases & Classifications for Cellulitis

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Cellulitis, Aliases & Descriptions:

Name: Cellulitis 8 44 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Cellulitis

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Diseases related to Cellulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 350)
idRelated DiseaseScoreTop Affiliating Genes
1orbital cellulitis32.5NT5C2
2endophthalmitis31.1LACTB
3conjunctivitis31.0IGES
4mediastinitis30.9CRP
5sinusitis30.7IL5, LACTB, DEFB4A, IGES
6bacteremia30.7LACTB, CRP
7folliculitis30.7DEFB4A
8dermatitis30.7IGES, IL5, ICAM1
9systemic lupus erythematosus30.6CRP
10osteomyelitis30.5CRP, LACTB
11leishmaniasis30.4IL5
12alopecia areata30.2IL1R1, ICAM1
13spondylarthropathy30.2CRP, TNF
14hypereosinophilic syndrome30.1IGES, IL5
15sarcoidosis30.0TNF, ICAM1, DEFB4A
16ankylosing spondylitis30.0TNF, CRP
17meningitis30.0CRP, LACTB
18peritonitis30.0TNF, LACTB, CRP
19vasculitis30.0ICAM1, CRP, TNF
20toxic shock syndrome30.0TNF, LACTB
21pyelonephritis30.0LACTB, CRP
22rheumatoid arthritis29.9IL1R1, CRP, TNF, ICAM1
23diabetes mellitus29.9CRP, IL1R1, ICAM1, TNF
24colitis29.8TNF, IL1R1, IGES, DEFB4A
25arthritis29.8IL1R1, ICAM1, LACTB, CRP, TNF
26eosinophilia29.7IL5, IL3, IGES
27sepsis29.7CRP, IL1R1, CAMP, LACTB, TNF, DEFB4A
28skin disease29.5TNF, ICAM1, IL5, DEFB4A, CAMP
29pneumonia29.4ICAM1, LACTB, TNF, IGES, IL5, CRP
30psoriasis29.4DEFB4A, TNF, ICAM1, IL1R1, IL5, CAMP
31leukemia29.4IL1R1, IL3, TNF, FLT4, LACTB, ICAM1
32tuberculosis29.3DEFB4A, CRP, CAMP, LACTB, TNF, IGES
33septic shock29.2LACTB, CAMP, CRP, TNF, IL1R1
34wells syndrome10.6
35dissecting cellulitis of the scalp10.6
36erysipelas10.6
37leukostasis10.5ICAM1
38rheumatoid vasculitis10.5ICAM1
39common cold10.5ICAM1
40schnitzler syndrome10.5IL1R1
41muckle-wells syndrome10.5IL1R1
42epidural abscess10.5CRP
43intrinsic asthma10.5IL5
44septic arthritis10.4CRP
45adult-onset still's disease10.4CRP
46eosinophilic gastroenteritis10.4IL5
47keratoconjunctivitis10.4IL5
48pharyngitis10.4LACTB
49exanthem10.4CRP
50malaria10.4ICAM1, TNF

Graphical network of the top 20 diseases related to Cellulitis:



Diseases related to cellulitis

Symptoms for Cellulitis

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Drugs & Therapeutics for Cellulitis

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Drug clinical trials:

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Genetic Tests for Cellulitis

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Anatomical Context for Cellulitis

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MalaCards organs/tissues related to Cellulitis:

32
Skin, Testes, Lymph node, Eye, T cells, Neutrophil, Breast, Bone, Lung, B cells, Brain, Colon, Kidney, Thyroid, Retina, Heart, Liver, Prostate, Myeloid

Animal Models for Cellulitis or affiliated genes

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MGI Mouse Phenotypes related to Cellulitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6TNF, ICAM1, IL5, IL3, IL1R1
2MP:00053978.3CAMP, IL1R1, IL3, IL5, ICAM1, TNF
3MP:00053767.6TNF, FLT4, ICAM1, IL5, IL3, IL1R1
4MP:00053877.5CRP, TNF, FLT4, ICAM1, IL5, IL3

Publications for Cellulitis

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Articles related to Cellulitis:

(show top 50)    (show all 935)
idTitleAuthorsYear
1
Concurrent Endophthalmitis and Orbital Cellulitis From Metastatic Klebsiella pneumonia Liver Abscess. (25186218)
2014
2
Supermicrosurgical anastomosis of superficial lymphatic vessel to deep lymphatic vessel for a patient with cellulitis-induced chronic localized leg lymphedema. (25197031)
2014
3
Superior ophthalmic vein thrombosis developed after orbital cellulitis. (23448556)
2013
4
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
5
Risk of deep vein thrombosis in patients with cellulitis and erysipelas: a systematic review and meta-analysis. (23948644)
2013
6
Oxacillin or cefalotin treatment of hospitalized children with cellulitis. (22274151)
2012
7
Recurrent metastatic breast carcinoma presenting with pansinusitis and choroidal metastases and subsequent bilateral simultaneous orbital cellulitis. (22352825)
2012
8
The hot orbit: orbital cellulitis. (22346113)
2012
9
Eosinophilic cellulitis (Wells syndrome) in a pediatric patient: a case report and review of the literature. (22611749)
2012
10
Identification of Legionella feeleii cellulitis. (21192884)
2011
11
Emphysematous cellulitis of the left thigh caused by sigmoid diverticulum perforation. (21780564)
2011
12
Decreased antibiotic utilization after implementation of a guideline for inpatient cellulitis and cutaneous abscess. (21357799)
2011
13
Number of flocks on the same litter and carcase condemnations due to cellulitis, arthritis and contact foot-pad dermatitis in broilers. (21058060)
2010
14
Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis: a case report. (20699010)
2010
15
Risk stratification and outcome of cellulitis admitted to hospital. (20346971)
2010
16
Orbital cellulitis in children-medical treatment versus surgical management. (19839897)
2009
17
Hypertrophic osteoarthropathy masquerading as lower extremity cellulitis and response to bisphosphonates. (19179906)
2009
18
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
19
Vaccination site reaction or bacterial cellulitis? (20357923)
2009
20
Dissecting cellulitis of the scalp treated with rifampicin and isotretinoin: case reports. (18856159)
2008
21
Refractory dissecting cellulitis of the scalp treated with adalimumab. (19112766)
2008
22
Moxifloxacin-associated neutropenia in a cirrhotic elderly woman with lower extremity cellulitis. (18349304)
2008
23
Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis. (17922409)
2007
24
Successful stem cell transplantation without cryopreservation from a microchimeric haploidentical sibling for refractory acute myeloid leukemia complicated with critical thrombophlebitis and cellulitis. (17261507)
2007
25
Eosinophilic cellulitis (Wells' syndrome) in association with angioimmunoblastic lymphadenopathy. (17989892)
2007
26
Orbital cellulitis after faden operation on the medial rectus. (18058359)
2007
27
Preseptal cellulitis caused by community acquired methicillin resistant Staphylococcus aureus (CAMRSA). (18024828)
2007
28
Kingella kingae orbital cellulitis in a 3-year-old. (16244644)
2006
29
Orbital cellulitis following cataract surgery. (16033368)
2005
30
Effect of corticosteroids in the acute management of pediatric orbital cellulitis with subperiosteal abscess. (16234700)
2005
31
Orbital cellulitis, panophthalmitis, and ecthyma gangrenosum in an immunocompromised host with pseudomonas septicemia. (14700664)
2004
32
Retinoblastoma presenting as orbital cellulitis: report of four cases with a review of the literature. (15559956)
2004
33
Orbital cellulitis associated with Toxocara canis in a dog. (14641832)
2003
34
Predictors of a positive duplex scan in patients with a clinical presentation compatible with deep vein thrombosis or cellulitis. (18159459)
2003
35
Periorbital versus orbital cellulitis. (12488668)
2002
36
Nodular presentation of eosinophilic cellulitis (Wells' syndrome). (11722455)
2001
37
Managing orbital cellulitis. (9559504)
1998
38
E coli panophthalmitis with orbital cellulitis. (9373510)
1997
39
Pediatric management problems: orbital cellulitis. (8700626)
1996
40
Orbital cellulitis in children: clinical analysis of 16 cases. (7572173)
1995
41
Acute orbital cellulitis after peribulbar injection. (8085597)
1994
42
Bipolaris-induced orbital cellulitis. (1287050)
1992
43
Anaerobic orbital cellulitis and septicemia in a dog. (17423898)
1991
44
Streptococcus faecalis orbital cellulitis. (3087259)
1986
45
Eosinophilic cellulitis (Wells' syndrome) (4015127)
1985
46
The role of high resolution computerized tomography and standardized ultrasound in the evaluation of orbital cellulitis. (7087639)
1982
47
Management and complications of bacterial periorbital and orbital cellulitis. (7185014)
1982
48
Primary dacryocystitis causing orbital cellulitis. (7114699)
1982
49
Gas in the orbit associated with orbital cellulitis and paranasal sinusitis. (4694394)
1973
50
Pneumonyssus caninum and orbital cellulitis in the dog. (5816723)
1969

Variations for Cellulitis

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Expression for genes affiliated with Cellulitis

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Expression patterns in normal tissues for genes affiliated with Cellulitis

Search GEO for disease gene expression data for Cellulitis.

Pathways for genes affiliated with Cellulitis

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Pathways related to Cellulitis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ICAM1, TNF
29.9ICAM1, TNF
39.9ICAM1, TNF
4
Show member pathways
Serotonin Transporter Activity37
9.8TNF, IL1R1
59.8IL5, TNF
69.5TNF, ICAM1, IL1R1
79.5IL1R1, ICAM1, TNF
89.5IL1R1, ICAM1, TNF
9
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5DEFB4A, TNF, IL1R1
10
Show member pathways
Immune response CD16 signaling in NK cells60
9.4IL3, ICAM1, TNF
11
Show member pathways
9.4FLT4, IL5, IL1R1
12
Show member pathways
thioredoxin pathway37
9.4CRP, ICAM1, TNF
13
Show member pathways
9.3IL1R1, IL3, TNF
14
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.3TNF, IL5, IL3
15
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.3TNF, IL5, IL3
169.3IL3, IL5, TNF
17
Show member pathways
9.2IL1R1, IL3, IL5
18
Show member pathways
9.1TNF, FLT4, IL3, IL1R1
19
Show member pathways
9.0IL3, IL5, ICAM1, TNF
209.0TNF, IL3, IL1R1, CAMP
21
Show member pathways
9.0ICAM1, IL5, IL3, IL1R1
228.9IL1R1, IL3, IL5, TNF
23
Show member pathways
8.7TNF, FLT4, IL5, IL3, IL1R1
24
Show member pathways
8.7TNF, FLT4, IL5, IL3, IL1R1
25
Show member pathways
8.7TNF, FLT4, IL5, IL3, IL1R1
26
Show member pathways
8.7TNF, FLT4, IL5, IL3, IL1R1
27
Show member pathways
8.7IL1R1, IL3, IL5, FLT4, TNF

Compounds for genes affiliated with Cellulitis

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Compounds related to Cellulitis according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1cdp571449.8TNF, ICAM1, CRP
2oxatomide449.7IL3, ICAM1, IL5
3nedocromil sodium449.7ICAM1, IL5, IL3
4tenidap44 2810.6TNF, IL1R1, CRP
5anakinra44 1110.6CRP, TNF, IL1R1
6azelastine44 1110.6IL3, IL5, ICAM1
7hydroxychloroquine44 1110.6CRP, IL1R1, TNF
8il-12449.6IL5, IL1R1, TNF
9polymyxin b449.6CAMP, TNF, ICAM1
10lipoteichoic acid449.6DEFB4A, CAMP, IL1R1, TNF
11pentoxifylline44 1110.5TNF, ICAM1, IL1R1, CAMP
12as 10144 6110.5IL1R1, IL5, IL3
13adalimumab44 50 1111.5CRP, IL1R1, TNF
14amphotericin b449.5IL5, IL1R1, CRP
15gm-csf44 2810.5IL5, IL3, ICAM1, TNF
16sulfasalazine28 44 50 1112.4TNF, ICAM1, IL1R1, CRP
17n-formylmethionyl-leucylphenylalanine449.4IL5, ICAM1, TNF, IL3
18percoll449.4CAMP, IL5, IL3
19ceftriaxone44 1110.4IL5, CRP, LACTB
20il 10449.3IL5, TNF, IL3, IL1R1
21okt3449.3TNF, CRP, ICAM1
22leukotriene b444 61 2411.3IL3, IL1R1, IL5, TNF
23hydrocortisone44 2 61 1112.2IL5, IL1R1, TNF, IL3
24herbimycin a44 6110.2IL5, TNF, IL3, ICAM1
25prednisolone44 28 1111.1CRP, IL1R1, IL5, TNF
26fmlp449.1IL5, CAMP, IL3, ICAM1, TNF
27pd 98,059449.1ICAM1, DEFB4A, TNF, CAMP, IL3
28methacholine44 50 1111.0IL5, IGES, ICAM1, CRP
29actinomycin d449.0ICAM1, TNF, IL3, IL1R1, CAMP
30neopterin449.0CRP, TNF, IL1R1, ICAM1, IL3
31prostacyclin449.0ICAM1, IL3, CAMP, CRP, TNF
32ionomycin449.0IL5, IL3, CAMP, TNF
33pge2448.9ICAM1, IL1R1, IL5, CAMP, TNF
34n acetylcysteine448.9TNF, CRP, IL3, ICAM1, IL1R1
35ivig448.9TNF, CRP, IL1R1, IL3, IL5
36endotoxin448.8CRP, IL1R1, ICAM1, TNF, DEFB4A, CAMP
37genistein44 28 61 2 24 1113.8CAMP, IL5, ICAM1, TNF, DEFB4A, IL3
38rantes448.8TNF, IL5, DEFB4A, IL1R1, IL3, ICAM1
39sb 20358044 619.7DEFB4A, IL1R1, CRP, TNF, IL5, ICAM1
40ly294002448.7IL3, CRP, TNF, FLT4, ICAM1, IL5
41heparin44 28 24 1111.6IL3, IL1R1, DEFB4A, CAMP, IL5
42cycloheximide448.5ICAM1, IL5, IL1R1, CRP, IL3, TNF
43cyclosporin a44 28 6110.4IL3, IL1R1, IL5, ICAM1, IGES, TNF
44vegf448.4IL5, ICAM1, IL1R1, FLT4, TNF, CAMP
45lactate448.3IL1R1, ICAM1, TNF, IGES, CRP, IL3
46histamine44 28 2410.2CAMP, DEFB4A, IL3, IL5, ICAM1, TNF
47dexamethasone44 50 28 1111.2TNF, FLT4, ICAM1, IL5, IL3, IL1R1
48retinoic acid44 249.2ICAM1, TNF, DEFB4A, IL1R1, IL3, IL5
49thymidine44 249.2TNF, NT5C2, IL5, IL3, IL1R1, CAMP
50tyrosine447.7CAMP, IL1R1, DEFB4A, FLT4, ICAM1, IL5

GO Terms for genes affiliated with Cellulitis

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Cellular components related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5CRP, IL3, IL5, ICAM1, TNF
2extracellular regionGO:0055767.5CRP, DEFB4A, TNF, FLT4, IL5, IL3

Biological processes related to Cellulitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of podosome assemblyGO:0718039.9IL5, TNF
2positive regulation of nitric oxide biosynthetic processGO:0454299.8ICAM1, TNF
3negative regulation of lipid storageGO:0108889.7TNF, CRP
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4IL3, IL5, ICAM1
5defense response to Gram-positive bacteriumGO:0508309.4CRP, TNF
6inflammatory responseGO:0069549.2CRP, IL5, TNF
7immune responseGO:0069559.0DEFB4A, IL5, IL3, IL1R1

Molecular functions related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL3, IL5, TNF
2protein bindingGO:0055157.2FLT4, ICAM1, NT5C2, IL5, IL1R1, CAMP

Products for genes affiliated with Cellulitis

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Sources for Cellulitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet