MCID: CLL003
MIFTS: 53

Cellulitis malady

Skin category

Summaries for Cellulitis

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Cellulitis is an infection of the skin and deep underlying tissues. group a strep (streptococcal) bacteria are the most common cause. the bacteria enter your body when you get an injury such as a bruise, burn, surgical cut, or wound. symptoms include fever and chills swollen glands or lymph nodes a rash with painful, red, tender skin. the skin may blister and scab over. your health care provider may take a sample or culture from your skin or do a blood test to identify the bacteria causing infection. treatment is with antibiotics. they may be oral in mild cases, or intravenous (through the vein) for more severe cases. nih: national institute of allergy and infectious diseases

MalaCards: Cellulitis is related to orbital cellulitis and sinusitis. An important gene associated with Cellulitis is BIN1 (bridging integrator 1), and among its related pathways are LDL Oxidation in Atherogenesis and Spinal Cord Injury. The compounds estrogen and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

Wikipedia:64 Cellulitis is a localized or diffuse inflammation of connective tissue with severe inflammation of... more...

Aliases & Classifications for Cellulitis

Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

cellulitis 8 45 34 61


Related Diseases for Cellulitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cellulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1orbital cellulitis31.6NT5C2
2sinusitis30.8DEFB4A
3sepsis30.3C5AR1, IL1R1, DEFB4A, TNF, CAMP
4arthritis30.2C5AR1, IL1R1, TNF, ICAM1
5adenocarcinoma30.0CDX2, CHKA, FLT4
6systemic lupus erythematosus29.9C5AR1, IL1R1, TNF, ICAM1
7bacterial vaginosis29.7IL1R1
8vasculitis29.7ICAM1, TNF
9alopecia areata29.7IL1R1, ICAM1
10septic shock29.7CAMP, TNF, IL1R1, C5AR1
11squamous cell carcinoma29.7IL1R1, CDX2, CHKA, DEFB4A, FLT4, CAMP
12wells syndrome10.6
13erysipelas10.5
14blindness10.3
15bacteremia10.3
16cavernous sinus thrombosis10.3
17dissecting cellulitis of the scalp10.3
18tinea unguium10.2
19n syndrome10.2
20orbit lymphoma10.2
21cryptococcosis10.2
22strabismus10.2
23tinea capitis10.2
24panophthalmitis10.2
25acute leukemia10.2
26acne10.2
27central retinal artery occlusion10.1
28hidradenitis suppurativa10.1
29ecthyma10.1
30nocardiosis10.0
31melioidosis10.0
32scarlet fever10.0
33polymyalgia rheumatica10.0
34thrombophlebitis10.0
35mycobacterium kansasii10.0
36orbital melanoma10.0
37rhinitis10.0ICAM1
38lung cancer10.0SLC5A7
39urticaria10.0C5AR1
40glioblastoma multiforme10.0FLT4
41crohn's disease10.0TNF
42myopathy10.0CHKA
43atopic dermatitis10.0DEFB4A
44adult respiratory distress syndrome10.0C5AR1
45neutropenia10.0C5AR1
46cerebral malaria10.0TNF, ICAM1
47acute pancreatitis10.0IL1R1
48rheumatoid vasculitis10.0ICAM1
49herpes simplex10.0CAMP, CDX2
50leukostasis10.0C5AR1, ICAM1

Graphical network of the top 20 diseases related to Cellulitis:



Diseases related to cellulitis

Clinical Features for Cellulitis

Drugs & Therapeutics for Cellulitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cellulitis

Drug clinical trials:

Search ClinicalTrials for Cellulitis

Search NIH Clinical Center for Cellulitis

Search CenterWatch for Cellulitis

Genetic Tests for Cellulitis

Anatomical Context for Cellulitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cellulitis:

33
Skin, Liver, Brain, Kidney, Lymph node, Lung, Retina, Heart, Colon, Thyroid, Breast, Prostate, Myeloid, Nk cells, T cells, B lymphoblasts, B cells, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Cellulitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cellulitis

Sources:
51PubMed
See all sources

Articles related to Cellulitis:

(show top 50)    (show all 916)
idTitleAuthorsYear
1
A rare case of cellulitis-like cutaneous metastasis of gastric adenocarcinoma. (23452256)
2014
2
Dermatitis and cellulitis in leopard geckos (Eublepharis macularius) caused by the Chrysosporium anamorph of Nannizziopsis vriesii. (23160542)
2013
3
The many faces of facial cellulitis. (23641888)
2013
4
A case of odontogenic orbital cellulitis causing blindness by severe tension orbit. (23400303)
2013
5
Antimicrobial activity against CA-MRSA and treatment of uncomplicated nonpurulent cellulitis. (23944241)
2013
6
Dermoscopy of early dissecting cellulitis of the scalp simulates alopecia areata. (22853959)
2013
7
Eosinophilic cellulitis induced by subcutaneous administration of interferon-I^. (23604053)
2013
8
Fungal infection, not diabetes, is risk factor for cellulitis. (22951556)
2012
9
Complicated periorbital cellulitis: case report and literature review. (21888754)
2012
10
Secondary aortoenteric fistula: a case report of acute aortic occlusion following cellulitis. (22572231)
2012
11
Once or twice-daily, algorithm-based intravenous cephazolin for home-based cellulitis treatment. (22862755)
2012
12
Nine years' review on preseptal and orbital cellulitis and emergence of community-acquired methicillin-resistant Staphylococus aureus in a tertiary hospital in India. (22011486)
2011
13
Orbital cellulitis: a rare presentation of metastatic bronchial carcinoma. (22937366)
2011
14
Orbital compression syndrome presenting as orbital cellulitis in a child with sickle cell anemia. (20386412)
2010
15
Diffuse large B-cell lymphoma masquerading as orbital cellulitis. (21135427)
2010
16
Citrobacter koseri cellulitis during anti-CD20 monoclonal antibody (ofatumumab) treatment for B-cell chronic lymphocytic leukaemia. (20107742)
2010
17
Orbital cellulitis in children-medical treatment versus surgical management. (19839897)
2009
18
A case of bilateral retinoblastoma with left orbital cellulitis. (19321854)
2009
19
Question: Can you identify this condition? This condition is orbital cellulitis. (19910597)
2009
20
Orbital cellulitis and cavernous sinus thrombosis secondary to necrobacillosis. (18600243)
2009
21
Eosinophilic cellulitis caused by adenocarcinoma of the lung. (20415684)
2009
22
Community-acquired methicillin-resistant Staphylococcus aureus orbital cellulitis in a non-immunocompromised child. (18155937)
2008
23
Histoplasmosis presenting as cellulitis 18 years after renal transplantation. (18671166)
2008
24
Clindamycin-resistant Clostridium perfringens cellulitis. (18558488)
2008
25
Penile cellulitis due to community-acquired methicillin-resistant Staphylococcus aureus in an HIV-positive man. (18595885)
2008
26
Orbital cellulitis and endophthalmitis in pseudomonas septicemia. (19085303)
2008
27
Streptococcus dysgalactiae cellulitis and toxic shock like syndrome in a Brown Swiss cow. (18182521)
2008
28
Recurrent, pruritic dermal plaques and bullae. Diagnosis: eosinophilic cellulitis (Wells syndrome). (17576951)
2007
29
Erysipelas and cellulitis: clinical and microbiological spectrum in an Italian tertiary care hospital. (16321649)
2005
30
Arcanobacterium haemolyticum sinusitis and orbital cellulitis. (12797314)
2003
31
Nodular presentation of eosinophilic cellulitis (Wells' syndrome). (11722455)
2001
32
Orbital cellulitis in children. (11698739)
2001
33
Risk factors for erysipelas of the leg (cellulitis): case-control study. (10364117)
1999
34
Orbital cellulitis due to Streptococcus pneumoniae in a previously healthy adult. (10525012)
1999
35
Orbital melanoma presenting as orbital cellulitis: a clinicopathologic report. (9700739)
1998
36
Orbital cellulitis in the acquired immunodeficiency syndrome. (9152142)
1997
37
Asymptomatic posterior orbital cellulitis resulting from ethmoid/maxillary sinusitis. (9037991)
1997
38
Orbital cellulitis demands early recognition, urgent admission and aggressive management. (7582417)
1995
39
Molluscum contagiosum presenting as cellulitis in an AIDS patient: cytologic and ultrastructural features. (7544721)
1995
40
Inflammatory tinea capitis (kerion) mimicking dissecting cellulitis. (1737695)
1992
41
Pseudomonas aeruginosa orbital cellulitis in four neutropenic patients. (1980507)
1990
42
Ecthyma gangrenosum without bacteremia or necrotic cellulitis: a localized form of septic vasculitis. (3632159)
1987
43
Thrombophlebitis and cellulitis due to Campylobacter fetus ssp. fetus. Report of four cases and a review of the literature. (3892221)
1985
44
The role of high resolution computerized tomography and standardized ultrasound in the evaluation of orbital cellulitis. (7087639)
1982
45
Many misjudge severity of orbital cellulitis. (7062533)
1982
46
Periorbital and orbital cellulitis in childhood. (7344761)
1981
47
Orbital cellulitis, sinusitis, and pneumonitis caused by penicillium sp in a cat. (7358563)
1980
48
Differentiation of orbital cellulitis from preseptal cellulitis by computed tomography. (733416)
1978
49
Orbital cellulitis and cavernous sinus thrombosis caused by rhabdomyosarcoma of the middle ear. (4640733)
1972
50
A case of orbital cellulitis secondary to suppurative pansinusitis: jacksonian epilepsy: drainage of the sinuses: recovery. (13848536)
1959

Genetic Variations for Cellulitis

Expression for genes affiliated with Cellulitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cellulitis

Search GEO for disease gene expression data for Cellulitis.

Pathways for genes affiliated with Cellulitis

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Cellulitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TNF, ICAM1
210.2IL1R1, TNF, ICAM1
3
Immune response Bacterial infections in normal airways
Hide members
10.1TNF, DEFB4A, IL1R1
410.1SLC5A7, IL1R1, TNF
510.1RFK, TNF, ICAM1
610.0IL1R1, TNF, ICAM1, TICAM1

Compounds for genes affiliated with Cellulitis

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Cellulitis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8DEFB4A
2cdp5714510.6ICAM1, TNF
3interferon gamma4510.6ICAM1, TNF
4polymyxin b4510.6TNF, ICAM1, CAMP
5sulfasalazine45 29 50 1113.6IL1R1, TNF, ICAM1
6n-tosyl-l-phenylalanine chloromethyl ketone4510.5TNF, ICAM1
7tenidap45 2911.5IL1R1, TNF
8diphenyleneiodonium4510.5IL1R1, TNF, ICAM1
9peptidoglycan45 2911.5TNF, DEFB4A, IL1R1
10anakinra45 1111.5IL1R1, TNF
11pentoxifylline45 1111.5CAMP, ICAM1, TNF, IL1R1
12ccl345 2911.5IL1R1, TNF, ICAM1
13lipoteichoic acid4510.5IL1R1, DEFB4A, TNF, CAMP
14neopterin4510.5IL1R1, TNF, ICAM1
15n-formylmethionyl-leucylphenylalanine4510.5C5AR1, TNF, ICAM1
16hydroxychloroquine45 1111.4IL1R1, TNF
17dexamethasone45 50 29 1113.4CAMP, DEFB4A, CHKA, IL1R1
18fmlp4510.4C5AR1, TNF, ICAM1, CAMP
19prostacyclin4510.4CAMP, ICAM1, TNF, C5AR1
20efalizumab45 1111.4ICAM1, TNF
21prostaglandin4510.4C5AR1, IL1R1, TNF, CAMP
22nacl4510.3C5AR1, IL1R1, DEFB4A, CAMP
23hbd24510.3CAMP, DEFB4A
24rantes4510.3ICAM1, TNF, DEFB4A, IL1R1, C5AR1
25histamine45 29 2412.3ICAM1, TNF, DEFB4A, C5AR1, CAMP
26oxygen45 2411.3ICAM1, TNF, FLT4, C5AR1
27pd 98,0594510.3CAMP, ICAM1, TNF, DEFB4A, C5AR1
28sb 20358045 6011.3ICAM1, TNF, DEFB4A, IL1R1, C5AR1
29genistein45 29 60 2 11 2415.3CAMP, ICAM1, TNF, DEFB4A, CHKA
30n acetylcysteine4510.3ICAM1, TNF, CHKA, IL1R1
31paraffin4510.3FLT4, DEFB4A, CHKA, CDX2, IL1R1
32leukotriene b445 60 2412.2TNF, IL1R1, C5AR1
33endotoxin4510.2C5AR1, IL1R1, DEFB4A, TNF, ICAM1, CAMP
34vitamin d4510.2CAMP, CHKA, CDX2, IL1R1, C5AR1
35fibrinogen4510.2ICAM1, TNF, IL1R1, C5AR1
36cellulose4510.2IL1R1, C5AR1
37ulinastatin4510.2ICAM1, TNF
38vegf4510.2CAMP, ICAM1, TNF, FLT4, IL1R1, C5AR1
39progesterone45 60 29 11 2414.1CAMP, DEFB4A, CHKA, CDX2, IL1R1
40retinoic acid45 2411.1IL1R1, CHKA, DEFB4A, FLT4, TNF, ICAM1
41thymidine45 2411.1CAMP, TNF, CHKA, NT5C2, CDX2, INPPL1
42h2o24510.1ICAM1, TNF, CHKA, IL1R1, C5AR1
43lipid459.9CAMP, TNF, DEFB4A, CHKA, INPPL1, IL1R1
44sp 60012545 6010.9ICAM1, TNF, DEFB4A
45steroid459.9IL1R1, CDX2, CHKA, DEFB4A, CAMP
46tyrosine459.8CAMP, ICAM1, FLT4, DEFB4A, CHKA, CDX2

GO Terms for genes affiliated with Cellulitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic cupGO:00189110.3BIN2, TNF

Biological processes related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of nitric oxide biosynthetic processGO:04542910.2TNF, ICAM1, TICAM1
2positive regulation of NF-kappaB transcription factor activityGO:05109210.2TNF, ICAM1, TICAM1
3positive regulation of chemokine biosynthetic processGO:04508010.2TNF, TICAM1
4positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TNF, FLT4, C5AR1

Molecular functions related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1choline bindingGO:03326510.2SLC5A7, CHKA

Products for genes affiliated with Cellulitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cellulitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet