MCID: CLL003
MIFTS: 58

Cellulitis malady

Skin diseases category
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Summaries for Cellulitis

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Cellulitis is an infection of the skin and deep underlying tissues. group a strep (streptococcal) bacteria are the most common cause. the bacteria enter your body when you get an injury such as a bruise, burn, surgical cut, or wound. symptoms include fever and chills swollen glands or lymph nodes a rash with painful, red, tender skin. the skin may blister and scab over. your health care provider may take a sample or culture from your skin or do a blood test to identify the bacteria causing infection. treatment is with antibiotics. they may be oral in mild cases, or intravenous (through the vein) for more severe cases. nih: national institute of allergy and infectious diseases

MalaCards: Cellulitis is related to orbital cellulitis and sinusitis. An important gene associated with Cellulitis is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are LDL Oxidation in Atherogenesis and African trypanosomiasis. The compounds cdp571 and oxatomide have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lymph node, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:8 A skin disease where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

Wikipedia:65 Cellulitis is a bacterial infection involving the skin. It specifically affects the dermis and... more...

Aliases & Classifications for Cellulitis

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8Disease Ontology, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 25ICD10
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Related Diseases for Cellulitis

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17GeneCards, 18GeneDecks
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Diseases related to Cellulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 347)
idRelated DiseaseScoreTop Affiliating Genes
1orbital cellulitis31.8NT5C2
2sinusitis30.8IL5, LACTB, DEFB4A, IGES
3endophthalmitis30.6LACTB
4bacteremia30.5LACTB, CRP
5conjunctivitis30.4IGES
6dermatitis30.4IGES, IL5, ICAM1
7mediastinitis30.3CRP
8sepsis30.2CRP, IL1R1, CAMP, LACTB, TNF, DEFB4A
9osteomyelitis30.2CRP, LACTB
10arthritis30.1IL1R1, ICAM1, LACTB, CRP, TNF
11folliculitis30.1DEFB4A
12systemic lupus erythematosus30.1CRP
13meningitis30.0CRP, LACTB
14leishmaniasis30.0IL5
15leukemia30.0IL1R1, IL3, TNF, FLT4, LACTB, ICAM1
16rheumatoid arthritis30.0IL1R1, CRP, TNF, ICAM1
17pneumonia30.0ICAM1, LACTB, TNF, IGES, IL5, CRP
18peritonitis29.9TNF, LACTB, CRP
19diabetes mellitus29.9CRP, IL1R1, ICAM1, TNF
20alopecia areata29.8IL1R1, ICAM1
21spondylarthropathy29.8CRP, TNF
22hypereosinophilic syndrome29.8IGES, IL5
23psoriasis29.8DEFB4A, TNF, ICAM1, IL1R1, IL5, CAMP
24tuberculosis29.8DEFB4A, CRP, CAMP, LACTB, TNF, IGES
25sarcoidosis29.8TNF, ICAM1, DEFB4A
26ankylosing spondylitis29.8TNF, CRP
27vasculitis29.8ICAM1, CRP, TNF
28toxic shock syndrome29.8TNF, LACTB
29pyelonephritis29.8LACTB, CRP
30eosinophilia29.7IL5, IL3, IGES
31skin disease29.6TNF, ICAM1, IL5, DEFB4A, CAMP
32septic shock29.6LACTB, CAMP, CRP, TNF, IL1R1
33wells syndrome10.6
34dissecting cellulitis of the scalp10.6
35erysipelas10.5
36blindness10.3
37influenza10.3
38retinoblastoma10.3
39cavernous sinus thrombosis10.3
40dacryocystitis10.3
41retinitis10.3
42tinea unguium10.2
43cryptococcosis10.2
44cataract10.2
45hidradenitis10.2
46myositis10.2
47strabismus10.2
48tinea capitis10.2
49panophthalmitis10.2
50choroiditis10.2

Graphical network of the top 20 diseases related to Cellulitis:



Diseases related to cellulitis

Symptoms for Cellulitis

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Drugs & Therapeutics for Cellulitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cellulitis

Search NIH Clinical Center for Cellulitis

Genetic Tests for Cellulitis

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Anatomical Context for Cellulitis

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33MalaCards
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MalaCards organs/tissues related to Cellulitis:

33
Skin, Testes, Lymph node, Eye, T cells, Breast, Lung, Bone, B cells, Brain, Kidney, Thyroid, Colon, Heart, Prostate, Myeloid, Liver, Retina

Animal Models for Cellulitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cellulitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6TNF, ICAM1, IL5, IL3, IL1R1
2MP:00053978.3CAMP, IL1R1, IL3, IL5, ICAM1, TNF
3MP:00053767.6TNF, FLT4, ICAM1, IL5, IL3, IL1R1
4MP:00053877.5CRP, TNF, FLT4, ICAM1, IL5, IL3

Publications for Cellulitis

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52PubMed
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Articles related to Cellulitis:

(show top 50)    (show all 903)
idTitleAuthorsYear
1
Superior ophthalmic vein thrombosis developed after orbital cellulitis. (23448556)
2013
2
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
3
Risk of deep vein thrombosis in patients with cellulitis and erysipelas: a systematic review and meta-analysis. (23948644)
2013
4
Orbital cellulitis caused by community-associated methicillin-resistant Staphylococcus aureus in a previously healthy neonate. (22503797)
2013
5
16S ribosomal RNA identification of Prevotella nigrescens from a case of cellulitis. (24003433)
2013
6
Oxacillin or cefalotin treatment of hospitalized children with cellulitis. (22274151)
2012
7
Recurrent metastatic breast carcinoma presenting with pansinusitis and choroidal metastases and subsequent bilateral simultaneous orbital cellulitis. (22352825)
2012
8
The hot orbit: orbital cellulitis. (22346113)
2012
9
Eosinophilic cellulitis (Wells syndrome) in a pediatric patient: a case report and review of the literature. (22611749)
2012
10
Identification of Legionella feeleii cellulitis. (21192884)
2011
11
Emphysematous cellulitis of the left thigh caused by sigmoid diverticulum perforation. (21780564)
2011
12
Decreased antibiotic utilization after implementation of a guideline for inpatient cellulitis and cutaneous abscess. (21357799)
2011
13
Number of flocks on the same litter and carcase condemnations due to cellulitis, arthritis and contact foot-pad dermatitis in broilers. (21058060)
2010
14
Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis: a case report. (20699010)
2010
15
Risk stratification and outcome of cellulitis admitted to hospital. (20346971)
2010
16
Orbital cellulitis in children-medical treatment versus surgical management. (19839897)
2009
17
Hypertrophic osteoarthropathy masquerading as lower extremity cellulitis and response to bisphosphonates. (19179906)
2009
18
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
19
Vaccination site reaction or bacterial cellulitis? (20357923)
2009
20
Dissecting cellulitis of the scalp treated with rifampicin and isotretinoin: case reports. (18856159)
2008
21
Refractory dissecting cellulitis of the scalp treated with adalimumab. (19112766)
2008
22
Moxifloxacin-associated neutropenia in a cirrhotic elderly woman with lower extremity cellulitis. (18349304)
2008
23
Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis. (17922409)
2007
24
Successful stem cell transplantation without cryopreservation from a microchimeric haploidentical sibling for refractory acute myeloid leukemia complicated with critical thrombophlebitis and cellulitis. (17261507)
2007
25
Eosinophilic cellulitis (Wells' syndrome) in association with angioimmunoblastic lymphadenopathy. (17989892)
2007
26
Preseptal cellulitis caused by community acquired methicillin resistant Staphylococcus aureus (CAMRSA). (18024828)
2007
27
Kingella kingae orbital cellulitis in a 3-year-old. (16244644)
2006
28
Orbital cellulitis following cataract surgery. (16033368)
2005
29
Effect of corticosteroids in the acute management of pediatric orbital cellulitis with subperiosteal abscess. (16234700)
2005
30
Orbital cellulitis, panophthalmitis, and ecthyma gangrenosum in an immunocompromised host with pseudomonas septicemia. (14700664)
2004
31
Retinoblastoma presenting as orbital cellulitis: report of four cases with a review of the literature. (15559956)
2004
32
Orbital cellulitis associated with Toxocara canis in a dog. (14641832)
2003
33
Predictors of a positive duplex scan in patients with a clinical presentation compatible with deep vein thrombosis or cellulitis. (18159459)
2003
34
Periorbital versus orbital cellulitis. (12488668)
2002
35
Nodular presentation of eosinophilic cellulitis (Wells' syndrome). (11722455)
2001
36
Managing orbital cellulitis. (9559504)
1998
37
E coli panophthalmitis with orbital cellulitis. (9373510)
1997
38
Pediatric management problems: orbital cellulitis. (8700626)
1996
39
Orbital cellulitis in children: clinical analysis of 16 cases. (7572173)
1995
40
Acute orbital cellulitis after peribulbar injection. (8085597)
1994
41
Bipolaris-induced orbital cellulitis. (1287050)
1992
42
Anaerobic orbital cellulitis and septicemia in a dog. (17423898)
1991
43
Streptococcus faecalis orbital cellulitis. (3087259)
1986
44
Eosinophilic cellulitis (Wells' syndrome) (4015127)
1985
45
The role of high resolution computerized tomography and standardized ultrasound in the evaluation of orbital cellulitis. (7087639)
1982
46
Management and complications of bacterial periorbital and orbital cellulitis. (7185014)
1982
47
Primary dacryocystitis causing orbital cellulitis. (7114699)
1982
48
Differentiation of orbital cellulitis from preseptal cellulitis by computed tomography. (733416)
1978
49
Gas in the orbit associated with orbital cellulitis and paranasal sinusitis. (4694394)
1973
50
Pneumonyssus caninum and orbital cellulitis in the dog. (5816723)
1969

Variations for Cellulitis

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Expression for genes affiliated with Cellulitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cellulitis

Search GEO for disease gene expression data for Cellulitis.

Pathways for genes affiliated with Cellulitis

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50PathCards, 53QIAGEN, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 61Tocris Bioscience, 55Reactome, 54R&D Systems
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Pathways related to Cellulitis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ICAM1, TNF
29.9TNF, ICAM1
39.9TNF, ICAM1
4
Show member pathways
Serotonin Transporter Activity38
9.8TNF, IL1R1
59.8TNF, IL5
69.5TNF, ICAM1, IL1R1
79.5ICAM1, TNF, IL1R1
89.5IL1R1, ICAM1, TNF
9
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5IL1R1, TNF, DEFB4A
10
Show member pathways
Immune response CD16 signaling in NK cells60
9.4ICAM1, TNF, IL3
11
Show member pathways
9.4IL5, FLT4, IL1R1
12
Show member pathways
thioredoxin pathway38
9.4TNF, ICAM1, CRP
13
Show member pathways
9.3IL1R1, TNF, IL3
14
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.3IL3, IL5, TNF
159.3TNF, IL5, IL3
16
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.3IL5, IL3, TNF
17
Show member pathways
9.2IL5, IL3, IL1R1
18
Show member pathways
9.1TNF, IL1R1, IL3, FLT4
19
Show member pathways
9.0IL5, TNF, ICAM1, IL3
209.0IL1R1, IL3, TNF, CAMP
21
Show member pathways
9.0IL1R1, IL3, IL5, ICAM1
228.9IL5, TNF, IL3, IL1R1
23
Show member pathways
8.7TNF, FLT4, IL3, IL1R1, IL5
24
Show member pathways
8.7IL3, IL1R1, IL5, FLT4, TNF
25
Show member pathways
8.7FLT4, IL1R1, IL3, IL5, TNF
26
Show member pathways
8.7IL5, TNF, IL1R1, IL3, FLT4
27
Show member pathways
8.7IL1R1, IL3, IL5, FLT4, TNF

Compounds for genes affiliated with Cellulitis

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45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Cellulitis according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1cdp571459.8TNF, ICAM1, CRP
2oxatomide459.7IL3, ICAM1, IL5
3nedocromil sodium459.7ICAM1, IL5, IL3
4tenidap45 2910.6TNF, IL1R1, CRP
5anakinra45 1110.6CRP, TNF, IL1R1
6azelastine45 1110.6IL3, IL5, ICAM1
7hydroxychloroquine45 1110.6CRP, IL1R1, TNF
8il-12459.6IL5, IL1R1, TNF
9polymyxin b459.6CAMP, TNF, ICAM1
10lipoteichoic acid459.6DEFB4A, CAMP, IL1R1, TNF
11pentoxifylline45 1110.5TNF, ICAM1, IL1R1, CAMP
12as 10145 6110.5IL1R1, IL5, IL3
13adalimumab45 51 1111.5CRP, IL1R1, TNF
14amphotericin b459.5IL5, IL1R1, CRP
15gm-csf45 2910.5IL5, IL3, ICAM1, TNF
16sulfasalazine29 45 51 1112.4TNF, ICAM1, IL1R1, CRP
17n-formylmethionyl-leucylphenylalanine459.4IL5, ICAM1, TNF, IL3
18percoll459.4CAMP, IL5, IL3
19ceftriaxone45 1110.4IL5, CRP, LACTB
20il 10459.3IL5, TNF, IL3, IL1R1
21okt3459.3TNF, CRP, ICAM1
22leukotriene b445 61 2411.3IL3, IL1R1, IL5, TNF
23hydrocortisone45 3 61 1112.2IL5, IL1R1, TNF, IL3
24herbimycin a45 6110.2IL5, TNF, IL3, ICAM1
25prednisolone45 29 1111.1CRP, IL1R1, IL5, TNF
26fmlp459.1IL5, CAMP, IL3, ICAM1, TNF
27pd 98,059459.1ICAM1, DEFB4A, TNF, CAMP, IL3
28methacholine45 51 1111.0IL5, IGES, ICAM1, CRP
29actinomycin d459.0ICAM1, TNF, IL3, IL1R1, CAMP
30neopterin459.0CRP, TNF, IL1R1, ICAM1, IL3
31prostacyclin459.0ICAM1, IL3, CAMP, CRP, TNF
32ionomycin459.0IL5, IL3, CAMP, TNF
33pge2458.9ICAM1, IL1R1, IL5, CAMP, TNF
34n acetylcysteine458.9TNF, CRP, IL3, ICAM1, IL1R1
35ivig458.9TNF, CRP, IL1R1, IL3, IL5
36endotoxin458.8CRP, IL1R1, ICAM1, TNF, DEFB4A, CAMP
37genistein45 29 61 3 24 1113.8CAMP, IL5, ICAM1, TNF, DEFB4A, IL3
38rantes458.8TNF, IL5, DEFB4A, IL1R1, IL3, ICAM1
39sb 20358045 619.7DEFB4A, IL1R1, CRP, TNF, IL5, ICAM1
40ly294002458.7IL3, CRP, TNF, FLT4, ICAM1, IL5
41heparin45 29 24 1111.6IL3, IL1R1, DEFB4A, CAMP, IL5
42cycloheximide458.5ICAM1, IL5, IL1R1, CRP, IL3, TNF
43cyclosporin a45 29 6110.4IL3, IL1R1, IL5, ICAM1, IGES, TNF
44vegf458.4IL5, ICAM1, IL1R1, FLT4, TNF, CAMP
45lactate458.3IL1R1, ICAM1, TNF, IGES, CRP, IL3
46histamine45 29 2410.2CAMP, DEFB4A, IL3, IL5, ICAM1, TNF
47dexamethasone45 51 29 1111.2TNF, FLT4, ICAM1, IL5, IL3, IL1R1
48retinoic acid45 249.2ICAM1, TNF, DEFB4A, IL1R1, IL3, IL5
49thymidine45 249.2TNF, NT5C2, IL5, IL3, IL1R1, CAMP
50tyrosine457.7CAMP, IL1R1, DEFB4A, FLT4, ICAM1, IL5

GO Terms for genes affiliated with Cellulitis

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16Gene Ontology
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Cellular components related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5CRP, IL3, IL5, ICAM1, TNF
2extracellular regionGO:0055767.5CRP, DEFB4A, TNF, FLT4, IL5, IL3

Biological processes related to Cellulitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of podosome assemblyGO:0718039.9IL5, TNF
2positive regulation of nitric oxide biosynthetic processGO:0454299.8ICAM1, TNF
3negative regulation of lipid storageGO:0108889.7TNF, CRP
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4IL3, IL5, ICAM1
5defense response to Gram-positive bacteriumGO:0508309.4CRP, TNF
6inflammatory responseGO:0069549.2CRP, IL5, TNF
7immune responseGO:0069559.0DEFB4A, IL5, IL3, IL1R1

Molecular functions related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL3, IL5, TNF
2protein bindingGO:0055157.2FLT4, ICAM1, NT5C2, IL5, IL1R1, CAMP

Products for genes affiliated with Cellulitis

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  • Antibodies
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Sources for Cellulitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet