MCID: CLL003
MIFTS: 56

Cellulitis malady

Skin diseases category

Summaries for Cellulitis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cellulitis is an infection of the skin and deep underlying tissues. group a strep (streptococcal) bacteria are the most common cause. the bacteria enter your body when you get an injury such as a bruise, burn, surgical cut, or wound. symptoms include fever and chills swollen glands or lymph nodes a rash with painful, red, tender skin. the skin may blister and scab over. your health care provider may take a sample or culture from your skin or do a blood test to identify the bacteria causing infection. treatment is with antibiotics. they may be oral in mild cases, or intravenous (through the vein) for more severe cases. nih: national institute of allergy and infectious diseases

MalaCards: Cellulitis is related to orbital cellulitis and dermatitis. An important gene associated with Cellulitis is BIN1 (bridging integrator 1), and among its related pathways are LDL Oxidation in Atherogenesis and Spinal Cord Injury. The compounds estrogen and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lymph node, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

Wikipedia:63 Cellulitis is a diffuse inflammation of connective tissue, caused by bacteria, with severe inflammation... more...

Aliases & Classifications for Cellulitis

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8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Cellulitis

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17GeneCards, 18GeneDecks
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Diseases related to Cellulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1orbital cellulitis31.6NT5C2
2dermatitis30.3ICAM1
3pneumonia30.1ICAM1, TNF, DEFB4A, C5AR1
4leukemia30.1C5AR1, IL1R1, CDX2, FLT4, TNF, ICAM1
5arthritis30.1C5AR1, IL1R1, TNF, ICAM1
6neutropenia30.0C5AR1
7adenocarcinoma30.0CDX2, CHKA, FLT4
8peritonitis29.8C5AR1, TNF
9psoriasis29.8CAMP, ICAM1, TNF, DEFB4A, IL1R1
10systemic lupus erythematosus29.8C5AR1, IL1R1, TNF, ICAM1
11lung cancer29.6SLC5A7
12bacterial vaginosis29.6IL1R1
13herpes simplex29.6CAMP, CDX2
14vasculitis29.6ICAM1, TNF
15sarcoidosis29.6ICAM1, TNF, DEFB4A
16alopecia areata29.6IL1R1, ICAM1
17skin disease29.6DEFB4A, TNF, ICAM1, CAMP
18squamous cell carcinoma29.6IL1R1, CDX2, CHKA, DEFB4A, FLT4, CAMP
19breast cancer29.6CAMP, FLT4, CHKA, CDX2, INPPL1, IL1R1
20erysipelas10.5
21influenza10.3
22retinoblastoma10.3
23endophthalmitis10.3
24cavernous sinus thrombosis10.2
25dissecting cellulitis of the scalp10.2
26dacryocystitis10.2
27retinitis10.2
28wells syndrome10.2
29tinea unguium10.2
30orbit lymphoma10.2
31cryptococcosis10.2
32cataract10.2
33hidradenitis10.2
34myositis10.2
35orbital disease10.2
36strabismus10.2
37tinea capitis10.2
38choroiditis10.1
39panophthalmitis10.1
40acute leukemia10.1
41acne10.1
42conjunctivitis10.1
43central retinal artery occlusion10.1
44hidradenitis suppurativa10.1
45ecthyma10.1
46ethmoid sinusitis10.1
47fasciitis10.1
48frontal sinusitis10.1
49mediastinitis10.1
50melanoma10.1

Graphical network of the top 20 diseases related to Cellulitis:



Diseases related to cellulitis

Clinical Features for Cellulitis

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Drugs & Therapeutics for Cellulitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Cellulitis

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Anatomical Context for Cellulitis

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32MalaCards
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MalaCards organs/tissues related to Cellulitis:

32
Skin, Testes, Lymph node, Eye, T cells, Breast, Lung, Bone, B cells, Brain, Kidney, Thyroid, Colon, Heart, Prostate, Myeloid, Liver, Retina

Animal Models for Cellulitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cellulitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.7TICAM1, ICAM1, TNF, CDX2, IL1R1, BIN1
2MP:00053709.7TNF, FLT4, PRKAB2, CHKA, IL1R1, TICAM1
3MP:00053879.1TICAM1, CAMP, ICAM1, TNF, FLT4, IL1R1
4MP:00053768.9PRKAB2, FLT4, TNF, ICAM1, TICAM1, CHKA
5MP:00107688.9RFK, TICAM1, CAMP, ICAM1, TNF, FLT4

Publications for Cellulitis

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50PubMed
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Articles related to Cellulitis:

(show top 50)    (show all 913)
idTitleAuthorsYear
1
Serratia marcescens: an unusual pathogen associated with snakebite cellulitis. (23416662)
2013
2
Successful treatment of steroid-dependent eosinophilic cellulitis with cyclosporine. (23277881)
2013
3
Oral flucloxacillin and phenoxymethylpenicillin versus flucloxacillin alone for the emergency department outpatient treatment of cellulitis: study protocol for a randomised controlled trial. (23732051)
2013
4
Wells syndrome (eosinophilic cellulitis): Proposed diagnostic criteria and a literature review of the drug-induced variant. (24421864)
2013
5
Fungal infection, not diabetes, is risk factor for cellulitis. (22951556)
2012
6
A case of unilateral periorbital cellulitis and mandibular osteomyelitis in a turkey flock. (22856207)
2012
7
Dissecting cellulitis of the scalp. (23286798)
2012
8
The risk of cellulitis in cirrhotic patients: a nationwide population-based study in taiwan. (23170154)
2012
9
Nine years' review on preseptal and orbital cellulitis and emergence of community-acquired methicillin-resistant Staphylococus aureus in a tertiary hospital in India. (22011486)
2011
10
Community-associated methicillin-resistant Staphylococcus aureus causing orbital cellulitis in Australian children. (21681121)
2011
11
Life-threatening cellulitis after traditional Samoan tattooing. (21299697)
2011
12
Osteosarcoma masked by osteomyelitis and cellulitis in a dog. (20740253)
2010
13
Eosinophilic cellulitis caused by adenocarcinoma of the lung. (20415684)
2009
14
Community-acquired methicillin-resistant Staphylococcus aureus orbital cellulitis in a non-immunocompromised child. (18155937)
2008
15
Histoplasmosis presenting as cellulitis 18 years after renal transplantation. (18671166)
2008
16
Infantile orbital cellulitis. (18319119)
2008
17
Streptococcus dysgalactiae cellulitis and toxic shock like syndrome in a Brown Swiss cow. (18182521)
2008
18
Posttraumatic cellulitis and ulcerative conjunctivitis caused by Yersinia enterocolitica O:8. (18806676)
2008
19
Preseptal cellulitis caused by community acquired methicillin resistant Staphylococcus aureus (CAMRSA). (18024828)
2007
20
Orbital cellulitis in children. (17486703)
2007
21
Bilateral eyelid edema and orbital cellulitis associated with Pott's puffy tumor. (17413642)
2007
22
Peripheral T-cell lymphoma masquerading as infectious cellulitis. (17337406)
2007
23
Recurrent, pruritic dermal plaques and bullae. Diagnosis: eosinophilic cellulitis (Wells syndrome). (17576951)
2007
24
Case report: dental infection leading to orbital cellulitis. (16756236)
2006
25
Orbital cellulitis as a postoperative complication of sub-Tenon anaesthesia in cataract surgery. (17181628)
2006
26
Orbital cellulitis, panophthalmitis, and ecthyma gangrenosum in an immunocompromised host with pseudomonas septicemia. (14700664)
2004
27
Intrasinus wood foreign body causing orbital cellulitis in congenital insensitivity to pain with anhidrosis syndrome. (14752319)
2004
28
Aeromonas hydrophila orbital cellulitis in a patient with myelodysplastic syndrome. (15077892)
2004
29
Orbital cellulitis in children. (11698739)
2001
30
Risk factors for erysipelas of the leg (cellulitis): case-control study. (10364117)
1999
31
Orbital cellulitis as a sole symptom of odontogenic infection. (10414168)
1999
32
Asymptomatic posterior orbital cellulitis resulting from ethmoid/maxillary sinusitis. (9037991)
1997
33
Periorbital and orbital cellulitis in the Haemophilus influenzae vaccine era. (9310918)
1997
34
Adenovirus conjunctivitis mimics preseptal and orbital cellulitis in young children. (8852918)
1996
35
Naso-orbital fracture leading to orbital cellulitis, and visual loss as a complication of chronic sinusitis. (8199152)
1994
36
Pneumococcal cellulitis and dysgammaglobulinemia. (1557198)
1992
37
Eosinophilic cellulitis: histologic features in a cutaneous mastocytoma. (1904827)
1991
38
Inflammatory tinea capitis (kerion) mimicking dissecting cellulitis. Occurrence in two adolescents. (2037403)
1991
39
The acute orbit: differentiation of orbital cellulitis from subperiosteal abscess by computerized tomography. (2027437)
1991
40
Orbital cellulitis with abscess formation caused by sinusitis. (2705707)
1989
41
Orbital cellulitis with abscess formation caused by sinusitis. (3355050)
1988
42
Orbital cellulitis due to mucormycosis. A case report. (3209080)
1988
43
Orbital cellulitis. (3954974)
1986
44
Thrombophlebitis and cellulitis due to Campylobacter fetus ssp. fetus. Report of four cases and a review of the literature. (3892221)
1985
45
Orbital cellulitis following dental extraction. (6535319)
1984
46
Gas in the orbit associated with orbital cellulitis and paranasal sinusitis. (4694394)
1973
47
Orbital cellulitis. (13399065)
1957
48
Left orbital cellulitis; abscess, suggestive of cavernous sinus thrombosis. (18933898)
1948
49
Orbital Cellulitis from Gas-producing Organisms. (20784121)
1942
50
Results of Orbital Cellulitis following Ethmoidal Operation. (19975132)
1911

Genetic Variations for Cellulitis

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Expression for genes affiliated with Cellulitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cellulitis

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Pathways for genes affiliated with Cellulitis

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51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Cellulitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TNF, ICAM1
210.2IL1R1, TNF, ICAM1
3
Immune response Bacterial infections in normal airways
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10.1TNF, DEFB4A, IL1R1
410.1SLC5A7, IL1R1, TNF
510.1RFK, TNF, ICAM1
610.0IL1R1, TNF, ICAM1, TICAM1

Compounds for genes affiliated with Cellulitis

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cellulitis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8DEFB4A
2cdp5714410.6ICAM1, TNF
3interferon gamma4410.6ICAM1, TNF
4polymyxin b4410.6TNF, ICAM1, CAMP
5sulfasalazine44 28 49 1113.6IL1R1, TNF, ICAM1
6n-tosyl-l-phenylalanine chloromethyl ketone4410.5TNF, ICAM1
7tenidap44 2811.5IL1R1, TNF
8diphenyleneiodonium4410.5IL1R1, TNF, ICAM1
9peptidoglycan44 2811.5TNF, DEFB4A, IL1R1
10anakinra44 1111.5IL1R1, TNF
11pentoxifylline44 1111.5CAMP, ICAM1, TNF, IL1R1
12ccl344 2811.5IL1R1, TNF, ICAM1
13lipoteichoic acid4410.5IL1R1, DEFB4A, TNF, CAMP
14neopterin4410.5IL1R1, TNF, ICAM1
15n-formylmethionyl-leucylphenylalanine4410.5C5AR1, TNF, ICAM1
16hydroxychloroquine44 1111.4IL1R1, TNF
17dexamethasone44 49 28 1113.4CAMP, DEFB4A, CHKA, IL1R1
18fmlp4410.4C5AR1, TNF, ICAM1, CAMP
19prostacyclin4410.4CAMP, ICAM1, TNF, C5AR1
20efalizumab44 1111.4ICAM1, TNF
21prostaglandin4410.4C5AR1, IL1R1, TNF, CAMP
22nacl4410.3C5AR1, IL1R1, DEFB4A, CAMP
23hbd24410.3CAMP, DEFB4A
24rantes4410.3ICAM1, TNF, DEFB4A, IL1R1, C5AR1
25histamine44 28 2412.3ICAM1, TNF, DEFB4A, C5AR1, CAMP
26oxygen44 2411.3ICAM1, TNF, FLT4, C5AR1
27pd 98,0594410.3CAMP, ICAM1, TNF, DEFB4A, C5AR1
28sb 20358044 5911.3ICAM1, TNF, DEFB4A, IL1R1, C5AR1
29genistein44 28 59 2 11 2415.3CAMP, ICAM1, TNF, DEFB4A, CHKA
30n acetylcysteine4410.3ICAM1, TNF, CHKA, IL1R1
31paraffin4410.3FLT4, DEFB4A, CHKA, CDX2, IL1R1
32leukotriene b444 59 2412.2TNF, IL1R1, C5AR1
33endotoxin4410.2C5AR1, IL1R1, DEFB4A, TNF, ICAM1, CAMP
34vitamin d4410.2CAMP, CHKA, CDX2, IL1R1, C5AR1
35fibrinogen4410.2ICAM1, TNF, IL1R1, C5AR1
36cellulose4410.2IL1R1, C5AR1
37ulinastatin4410.2ICAM1, TNF
38vegf4410.2CAMP, ICAM1, TNF, FLT4, IL1R1, C5AR1
39progesterone44 59 28 11 2414.1CAMP, DEFB4A, CHKA, CDX2, IL1R1
40retinoic acid44 2411.1IL1R1, CHKA, DEFB4A, FLT4, TNF, ICAM1
41thymidine44 2411.1CAMP, TNF, CHKA, NT5C2, CDX2, INPPL1
42h2o24410.1ICAM1, TNF, CHKA, IL1R1, C5AR1
43lipid449.9CAMP, TNF, DEFB4A, CHKA, INPPL1, IL1R1
44sp 60012544 5910.9ICAM1, TNF, DEFB4A
45steroid449.9IL1R1, CDX2, CHKA, DEFB4A, CAMP
46tyrosine449.8CAMP, ICAM1, FLT4, DEFB4A, CHKA, CDX2

GO Terms for genes affiliated with Cellulitis

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16Gene Ontology
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Cellular components related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic cupGO:00189110.3BIN2, TNF

Biological processes related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of nitric oxide biosynthetic processGO:04542910.2TNF, ICAM1, TICAM1
2positive regulation of NF-kappaB transcription factor activityGO:05109210.2TNF, ICAM1, TICAM1
3positive regulation of chemokine biosynthetic processGO:04508010.2TNF, TICAM1
4positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TNF, FLT4, C5AR1

Molecular functions related to Cellulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1choline bindingGO:03326510.2SLC5A7, CHKA

Products for genes affiliated with Cellulitis

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Sources for Cellulitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet