CCHS
MCID: CNT097
MIFTS: 59

Central Hypoventilation Syndrome, Congenital (CCHS) malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Gastrointestinal diseases

Aliases & Classifications for Central Hypoventilation Syndrome, Congenital

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 23GeneReviews, 24GeneTests, 25Genetics Home Reference, 27GTR, 30ICD10, 31ICD10 via Orphanet, 37MedGen, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Central Hypoventilation Syndrome, Congenital:

Name: Central Hypoventilation Syndrome, Congenital 52 70 50
Congenital Central Hypoventilation Syndrome 11 23 48 24 25 70 13
Cchs 11 48 24 25 54 70
Haddad Syndrome 52 25 54 27
Ondine Curse 11 24 54 70
Congenital Central Alveolar Hypoventilation Syndrome 11 54 68
Congenital Failure of Autonomic Control 48 25 70
Congenital Central Hypoventilation 25 27 68
Central Hypoventilation Syndrome 52 27 12
Ondine Syndrome 11 25 54
Central Congenital Hypoventilation Syndrome 11 54
Ondine-Hirschsprung Disease 25 54
 
Hypoventilation 39 68
Central Hypoventilation Syndrome, Congenital, with or Without Hirschsprung Disease 52
Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome 54
Idiopathic Congenital Central Alveolar Hypoventilation 48
Central Alveolar Hypoventilation Syndrome 68
Sleep-Related Respiratory Failure 68
Primary Alveolar Hypoventilation 48
Cchs with Hirschsprung Disease 68
Ondine-Hirschsprung Syndrome 54
Congenital Ondine Curse 48
Sleep Apnea, Central 68

Characteristics:

Orphanet epidemiological data:

54
haddad syndrome:
Inheritance: Autosomal dominant,Multigenic/multifactorial; Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal
cchs:
Inheritance: Autosomal dominant,Not applicable; Age of onset: Infancy,Neonatal; Age of death: normal life expectancy

HPO:

64
central hypoventilation syndrome, congenital:
Inheritance: autosomal dominant inheritance
Mortality/Aging: death in infancy

GeneReviews:

23
Penetrance: penetrance for the phox2b polyalanine repeat expansion mutation appears to be high. amiel et al [2003], sasaki et al [2003], weese-mayer et al [2003], matera et al [2004], and berry-kravis et al [2006] found no controls with a phox2b polyalanine repeat expansion mutation...


Classifications:



External Ids:

OMIM52 209880
Disease Ontology11 DOID:0060731
ICD1030 G47.3
ICD10 via Orphanet31 G47.3
UMLS via Orphanet69 C1275808, C1859587
MESH via Orphanet40 C536209

Summaries for Central Hypoventilation Syndrome, Congenital

About this section
OMIM:52 Idiopathic congenital central hypoventilation syndrome, also known as 'Ondine's curse' (Deonna et al., 1974), is a rare... (209880) more...

MalaCards based summary: Central Hypoventilation Syndrome, Congenital, also known as congenital central hypoventilation syndrome, is related to hirschsprung disease 1 and perry syndrome, and has symptoms including constipation, constipation and increased sweating. An important gene associated with Central Hypoventilation Syndrome, Congenital is PHOX2B (Paired Like Homeobox 2b), and among its related pathways are Dopaminergic Neurogenesis and Neural Crest Differentiation. The drugs medroxyprogesterone acetate and medroxyprogesterone have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and heart, and related mouse phenotypes are shRNA abundance <= 50% and digestive/alimentary.

Disease Ontology:11 An autonomic nervous system disease characterized by reduced responsiveness of the respiratory center to carbon dioxide, diminished pupillary light responses, and other symptoms related to defects in the autonomic nervous system and that has material basis in most commonly heterozygous mutation in the PHOX2B gene on chromosome 4p13 and less frequently mutations in the RET, GDNF, EDN3, BDNF, or ASCL1 genes.

Genetics Home Reference:25 Congenital central hypoventilation syndrome (CCHS) is a disorder that affects breathing. People with this disorder take shallow breaths (hypoventilate), especially during sleep, resulting in a shortage of oxygen and a buildup of carbon dioxide in the blood. Ordinarily, the part of the nervous system that controls involuntary body processes (autonomic nervous system) would react to such an imbalance by stimulating the individual to breathe more deeply or wake up. This reaction is impaired in people with CCHS, and they must be supported with a machine to help them breathe (mechanical ventilation) or a device that stimulates a normal breathing pattern (diaphragm pacemaker). Some affected individuals need this support 24 hours a day, while others need it only at night.

NIH Rare Diseases:48 Congenital central hypoventilation syndrome (cchs) is a disorder of the autonomic nervous system that affects breathing. it causes a person to hypoventilate (especially during sleep), resulting in a shortage of oxygen and a buildup of carbon dioxide in the blood. symptoms usually begin shortly after birth. affected infants hypoventilate upon falling asleep and exhibit a bluish appearance of the skin or lips (cyanosis). other features may include difficulty regulating heart rate and blood pressure; decreased perception of pain; low body temperature; sporadic profuse sweating; hirschsprung disease; constipation; learning difficulties; eye abnormalities; and a characteristic facial appearance (having a short, wide, somewhat flattened face). cchs is caused by a mutation in the phox2b gene and is inherited in an autosomal dominant manner. however, over 90% of cases are due to a new mutation in the affected person and are not inherited from a parent. treatment typically includes mechanical ventilation or use of a diaphragm pacemaker. last updated: 1/12/2016

UniProtKB/Swiss-Prot:70 Congenital central hypoventilation syndrome: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.

Wikipedia:71 Central hypoventilation syndrome (CHS) is a respiratory disorder that results in respiratory arrest... more...

GeneReviews for NBK1427

Related Diseases for Central Hypoventilation Syndrome, Congenital

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Diseases related to Central Hypoventilation Syndrome, Congenital via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung disease 131.6EDNRB, GDNF, RET
2perry syndrome11.9
3rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome11.9
4rohhad10.9
5epiphyseal dysplasia, multiple, 310.3EDN3, EDNRB
6waardenburg syndrome, type 4a10.2EDNRB, RET
7meigel disease10.2GDNF, RET
8ceroid lipofuscinosis, neuronal, 510.2EDN3, EDNRB, RET
9hemopericardium10.2ASCL1, EDNRB, PHOX2B
10hypoparathyroidism-intellectual disability-dysmorphism syndrome10.2GDNF, RET, TH
11cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk10.2BDNF, TH
12sweat gland cancer10.1EDNRB, GDNF, RET
13wdha syndrome10.1EDN3, EDNRB
14postmenopausal atrophic vaginitis10.1BDNF, PHOX2B, TH
15ariboflavinosis10.1EDN3, EDNRB, GDNF, RET
16neutropenia, severe congenital, 5, autosomal recessive10.1ASCL1, EDNRB, GDNF, RET
17cystadenoma10.1BDNF, PHOX2B, TH
18pheochromocytoma10.1ASCL1, GDNF, RET, TH
19spinal meningioma10.0EDN3, EDNRB, GDNF, PHOX2B, RET
20shprintzen-goldberg syndrome10.0ASCL1, EDN3, EDNRB, GDNF, RET
21atrial fibrillation, familial, 1010.0ASCL1, BDNF, PHOX2A, PHOX2B, TH
22sudden infant death syndrome10.0
23skin pilomatrix carcinoma10.0ASCL1, EDN3, EDNRB, GDNF, PHOX2B, RET
24myopathy of extraocular muscle10.0EDN3, EDNRB, RET
25tooth agenesis, selective, 510.0ASCL1, EDN3, EDNRB, GDNF, PHOX2B, RET
26anterior spinal artery syndrome9.9
27neuroblastoma9.9
28sleep apnea9.9
29cerebritis9.9
30autonomic dysfunction9.8
31hypoglycemia9.8
32pulmonary hypertension9.7
33obstructive sleep apnea9.7
34thrombosis9.7
35esophagitis9.7
36down syndrome9.7
37hyperinsulinism9.7
38ganglioneuroblastoma9.7
39hyperglycemia9.7
40ganglioneuroma9.7
41hyperthyroidism9.7
42neuronitis9.7
43influenza9.7
44learning disability9.7
45narcolepsy9.7
46central sleep apnea9.7
47meningitis9.7
48encephalitis9.7
49haemophilus influenzae9.7
50hypoxia9.7

Graphical network of the top 20 diseases related to Central Hypoventilation Syndrome, Congenital:



Diseases related to central hypoventilation syndrome, congenital

Symptoms & Phenotypes for Central Hypoventilation Syndrome, Congenital

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Symptoms by clinical synopsis from OMIM:

209880

Clinical features from OMIM:

209880

Human phenotypes related to Central Hypoventilation Syndrome, Congenital:

 54 64 (show all 34)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures64 54 Occasional (29-5%) HP:0001250
2 muscular hypotonia64 54 Occasional (29-5%) HP:0001252
3 respiratory insufficiency64 54 Very frequent (99-80%) HP:0002093
4 aganglionic megacolon64 54 Occasional (29-5%) HP:0002251
5 abnormality of the autonomic nervous system54 Very frequent (99-80%)
6 ganglioneuroma64 54 Occasional (29-5%) HP:0003005
7 neuroblastoma64 54 Occasional (29-5%) HP:0003006
8 ganglioneuroblastoma64 54 Occasional (29-5%) HP:0006747
9 neoplasm of the central nervous system54 Occasional (29-5%)
10 cognitive impairment64 54 Occasional (29-5%) HP:0100543
11 sensorineural hearing impairment64 54 Occasional (29-5%) HP:0000407
12 strabismus64 54 Very frequent (99-80%) HP:0000486
13 intellectual disability64 54 Frequent (79-30%) HP:0001249
14 failure to thrive64 54 Very frequent (99-80%) HP:0001508
15 small for gestational age64 54 Very frequent (99-80%) HP:0001518
16 death in infancy54 Frequent (79-30%)
17 decreased fetal movement64 54 Occasional (29-5%) HP:0001558
18 polyhydramnios64 54 Occasional (29-5%) HP:0001561
19 oligohydramnios64 54 Occasional (29-5%) HP:0001562
20 gastroesophageal reflux64 54 Frequent (79-30%) HP:0002020
21 autonomic dysregulation64 54 Very frequent (99-80%) HP:0002271
22 dysautonomia64 54 Very frequent (99-80%) HP:0002459
23 breathing dysregulation64 54 Very frequent (99-80%) HP:0005957
24 central hypoventilation64 54 Very frequent (99-80%) HP:0007110
25 central sleep apnea64 54 Very frequent (99-80%) HP:0010536
26 abnormality of the mouth64 HP:0000153
27 posteriorly rotated ears64 HP:0000358
28 low-set ears64 HP:0000369
29 downslanted palpebral fissures64 HP:0000494
30 hyperhidrosis64 HP:0000975
31 abnormality of the cardiovascular system64 HP:0001626
32 constipation64 HP:0002019
33 abnormality of temperature regulation64 HP:0004370
34 feeding difficulties64 HP:0011968

UMLS symptoms related to Central Hypoventilation Syndrome, Congenital:


constipation, increased sweating, cheyne-stokes respiration, coughing, dyspnea, hemoptysis, hoarseness, signs and symptoms, respiratory, shallow breathing, paradoxical respiration, hyperoxia

GenomeRNAi Phenotypes related to Central Hypoventilation Syndrome, Congenital according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00343-S6.5GPR4, KCNK5, PHOX2A, PHOX2B, PMPCA, RET

MGI Mouse Phenotypes related to Central Hypoventilation Syndrome, Congenital according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1BDNF, EDN3, EDNRB, GDNF, RET, TLX2
2MP:00030128.8ASCL1, BDNF, DBX1, KCNK5, MARK3, PHOX2A
3MP:00053887.3ASCL1, BDNF, DBX1, EDNRB, GPR4, KCNK5
4MP:00053767.2BDNF, DBX1, EDNRB, GPR4, KCNK5, MARK3
5MP:00053787.2ASCL1, BDNF, DBX1, EDNRB, GDNF, KCNK5
6MP:00053866.8ASCL1, BDNF, DBX1, EDN3, EDNRB, GDNF
7MP:00036316.3ASCL1, BDNF, DBX1, EDN3, EDNRB, GDNF
8MP:00107686.0ASCL1, BDNF, DBX1, EDN3, EDNRB, GDNF

Drugs & Therapeutics for Central Hypoventilation Syndrome, Congenital

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Drugs for Central Hypoventilation Syndrome, Congenital (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 108)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Riluzoleapproved, investigationalPhase 4651744-22-55070
Synonyms:
1744-22-5
2-Amino-6-(trifluoromethoxy)-benzothiazole
2-Amino-6-(trifluoromethoxy)benzothiazole
2-Amino-6-trifluoro- methoxybenzothiazole
2-amino-6-(trifluoromethoxy)-1,3-benzothiazole
2-amino-6-(trifluoromethoxy)benzo[d]thiazole
2-amino-6-(trifluoromethoxyl)benzothiazole
2-amino-6-trifluoromethoxybenzothiazole
6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
6-(trifluoromethoxy)benzo[d]thiazol-2-amine
6-Trifluoromethoxy-benzothiazol-2-ylamine
6-trifluoromethoxybenzothiazole-2-yl-amine
AC-730
AC1L1JJL
AC1Q530H
AKOS000265071
ALBB-006046
Amino-2 trifluoromethoxy-6 benzothiazole
Amino-2 trifluoromethoxy-6 benzothiazole [French]
BB_SC-4839
BF-37
BIDD:GT0055
BPBio1_000037
BPBio1_000837
BRD-K21283037-001-02-5
BRD-K21283037-003-03-9
BSPBio_000033
Bio1_000416
Bio1_000905
Bio1_001394
Biomol-NT_000245
C07937
C8H5F3N2OS
CHEMBL744
CID5070
D00775
DB00740
EU-0101064
FT-0082997
HMS1773G08
HMS2089O19
HMS2094G07
I01-2084
LS-40688
 
Lopac-R-116
Lopac0_001064
MLS000069369
MolPort-000-151-262
NCGC00015882-01
NCGC00015882-02
NCGC00015882-03
NCGC00015882-07
NCGC00015882-11
NCGC00023141-02
NCGC00023141-04
NCGC00023141-05
NCGC00023141-06
PK-26124
PK-26124, RP-54274, Rilutek, Riluzole
Prestwick-03A08
Prestwick0_000167
Prestwick1_000167
Prestwick2_000167
Prestwick3_000167
R-116
R116_SIGMA
RP 54274
RP-54274
Rilutek
Rilutek (TN)
Riluzol
Riluzol [INN-Spanish]
Riluzole
Riluzole (JAN/USAN/INN)
Riluzole HCl
Riluzole [USAN:INN]
Riluzolum
Riluzolum [INN-Latin]
S1614_Selleck
SMR000058231
SPBio_000599
SPBio_001954
STK503686
Spectrum2_000550
Tocris-0768
UNII-7LJ087RS6F
ZERO/001785
ZINC00006481
riluzole
2
Naloxoneapproved, vet_approvedPhase 4252465-65-65284596
Synonyms:
(-)-N-allyl-14-hydroxynordihydroxymorphinan-6-one
(-)-Naloxone
(5alpha)-3,14-dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one
(5alpha)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one
1-N-Allyl-14-hydroxynordihydromorphinone
1-N-Allyl-7,8-dihydro-14-hydroxynormorphinone
12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furanone
12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5(6H)-one
17-Allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one
17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one
17-Allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one
17-allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one
3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one
357-08-4 (hydrochloride)
465-65-6
BIDD:GT0110
BPBio1_000136
BRD-K67511046-003-03-7
BRN 1089071
BSPBio_000122
C07252
CHEBI:7459
CHEMBL80
CID5284596
D08249
DB01183
DBL Naloxone
DBL Naloxone (TN)
EINECS 207-365-7
EN 1530 Base
EN 1530 base
HMS2090F20
HSDB 3279
L-Naloxone
LS-187184
LS-92141
 
MolPort-002-536-640
Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy- (8CI)
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)- (9CI)
N-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon
N-Allyl-noroxymorphone
N-Allylnoroxymorphone
NCGC00024674-02
NSC 70413
NSC70413
Nalone
Nalossone
Nalossone [DCIT]
Nalossone [Dcit]
Naloxona
Naloxona [INN-Spanish]
Naloxone
Naloxone (INN)
Naloxone HCl
Naloxone [INN:BAN]
Naloxonum
Naloxonum [INN-Latin]
Narcan
Narcanti
Narcon
PDSP2_001520
Prestwick0_000111
Prestwick1_000111
Prestwick2_000111
Prestwick3_000111
SMP1_000205
SPBio_002061
STOCK1N-69923
UNII-36B82AMQ7N
l-N-Allyl-14-hydroxynordihydromorphinone
l-N-Allyl-7,8-dihydro-14-hydroxynormorphinone
l-Naloxone
n-Allylnoroxymorphone
naloxone
3
Oxycodoneapproved, illicit, investigationalPhase 437976-42-65284603
Synonyms:
(-)-14-Hydroxydihydrocodeinone
(-)-Oxycodone
(5alpha)-14-hydroxy-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one
124-90-3 (hydrochloride)
14-Hydroxydihydrocodeinone
14-hydroxy-3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one
25333-72-6 (Terephthalate)
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5.alpha.-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
76-42-6
AC-16043
AC1Q4DTG
BRN 0043446
C08018
CHEBI:7852
CHEMBL656
CID5284603
Combunox
D05312
DB00497
DEA No. 9143
Dihydro-14-hydroxycodeinone
Dihydrohydroxycodeinone
Dihydrohydroxycondeinone
Dihydrone
Dihydroxycodeinone
Dinarkon
Diphydrone
EINECS 200-960-2
Endine (Australia)
Endocet
Endodan
Endone
Eubine
Eubine [France]
Eucodal
Eucodalum
Eukodal
Eutagen
HSDB 3142
Hydroxycodeinon
LS-92148
MolPort-004-285-989
Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl- (8CI)
NSC 19043
NSC19043
 
Ossicodone
Ossicodone [DCIT]
Oxanest
Oxicodona
Oxicodona [INN-Spanish]
Oxicon
Oxicone
Oxiconum
Oxikon
OxyFAST
OxyIR
OxyNorm
Oxycodeinon
Oxycodeinone
Oxycodon
Oxycodone
Oxycodone (USAN/INN)
Oxycodone Concentrate
Oxycodone Hcl
Oxycodone Hydrochloride
Oxycodone [USAN:INN:BAN]
Oxycodone hydrochloride
Oxycodonum
Oxycodonum [INN-Latin]
Oxycon
Oxycone
Oxycontin
Oxyfast
Oxynorm
PTI-821
Pancodine
Pancodone retard (United Kingdom)
Percobarb
Percodan
Percolone
Remoxy
Roxicet
Roxicodone
Supendol
Supendol [Canada]
Supeudol
Tecodin
Tekodin
Tekodin (free base)
Thecodine
Thekodin
Theocodin
UNII-CD35PMG570
WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JO1 P1
oxycodone
4
Acetazolamideapproved, vet_approvedPhase 4, Phase 38059-66-51986
Synonyms:
1424-27-7 (mono-hydrochloride salt)
1yda
1ydb
1ydd
1zsb
2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
2h4n
3czv
4-Diamox
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
5-acetylamino-1,3,4-thiadiazole-2-sulfonamide
5661-25-6
59-66-5
8017-69-4
A 6011
A6011_SIAL
A6011_SIGMA
AB00051906
AC-12779
AC1L1CO5
AI3-52458
AKOS000715163
Acetadiazol
Acetamidothiadiazolesulfonamide
Acetamox
Acetazolam
Acetazolamid
Acetazolamida
Acetazolamida [INN-Spanish]
Acetazolamide (AAZ)
Acetazolamide (JP15/USP/INN)
Acetazolamide Apotex Brand
Acetazolamide Chiesi Brand
Acetazolamide Dioptic Brand
Acetazolamide Grin Brand
Acetazolamide ICN Brand
Acetazolamide Jumer Brand
Acetazolamide Llorens Brand
Acetazolamide Medphano Brand
Acetazolamide Novopharm Brand
Acetazolamide Orion Brand
Acetazolamide Sodium
Acetazolamide Sodium, (Sterile)
Acetazolamide Wassermann Brand
Acetazolamide [INN:BAN:JAN]
Acetazolamide, Monosodium Salt
Acetazolamidum
Acetazolamidum [INN-Latin]
Acetazolamine
Acetazoleamide
Acetozalamide
Acétazolamide
Ak Zol
Ak-Zol
AkZol
Apo Acetazolamide
Apo-Acetazolamide
ApoAcetazolamide
Apotex Brand of Acetazolamide
Atenezol
BAS 01585728
BIDD:GT0643
BPBio1_000007
BSPBio_000005
BSPBio_001788
C06805
C4H6N4O3S2
CAS-59-66-5
CCRIS 5811
CHEBI:27690
CHEMBL20
CID1986
CPD0-1626
CPD000058394
Carbonic Anhydrase Inhibitor 6063
Carbonic Anhydrase Inhibitor No. 6063
Carbonic anhydrase inhibitor 6063
Chiesi Brand of Acetazolamide
Ciba Vision Brand of Acetazolamide
Cidamex
D000086
D00218
DB00819
Dazamide
Defiltran
Dehydratin
Diacarb
Diakarb
Diamox
Diamox (TN)
Diamox Sequels
Didoc
Diluran
 
Dioptic Brand of Acetazolamide
Diuramid
Diuramide
Diureticum-Holzinger
Diureticum-holzinger
Diuriwas
Diutazol
DivK1c_000017
Donmox
Duiramid
EINECS 200-440-5
EU-0100039
Edemox
Eumicton
Fonurit
Glauconox
Glaumox
Glaupax
Glupax
Grin Brand of Acetazolamide
HMS1568A07
HMS1920A05
HMS2091G05
HMS500A19
HSDB 3002
Huma Zolamide
Huma-Zolamide
HumaZolamide
I09-0425
ICN Brand of Acetazolamide
IDI1_000017
Jumer Brand of Acetazolamide
KBio1_000017
KBio2_000358
KBio2_002926
KBio2_005494
KBio3_001288
KBioGR_000558
KBioSS_000358
LS-10227
Llorens Brand of Acetazolamide
Lopac-A-6011
Lopac0_000039
MLS000028435
MLS001148438
Medphano Brand of Acetazolamide
MolPort-001-783-578
Monosodium Salt Acetazolamide
N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide
NCGC00015074-01
NCGC00015074-02
NCGC00015074-03
NCGC00015074-06
NCGC00015074-11
NCGC00023455-03
NCGC00023455-04
NCGC00023455-05
NCGC00023455-06
NCGC00023455-07
NINDS_000017
NSC 145177
NSC145177
Natrionex
Nephramid
Nephramide
Novopharm Brand of Acetazolamide
Orion Brand of Acetazolamide
Phonurit
Prestwick0_000003
Prestwick1_000003
Prestwick2_000003
Prestwick3_000003
Prestwick_4
SAM002554883
SBB056640
SK-acetazolamide
SMR000058394
SPBio_000004
SPBio_001926
SPECTRUM1500102
Sk-Acetazolamide
Spectrum2_000082
Spectrum3_000284
Spectrum4_000139
Spectrum5_000738
Spectrum_000018
Storz Brand of Acetazolamide Preparation
Storzolamide
UNII-O3FX965V0I
Vetamox
WLN: T5NN DSJ CSZW EMV1
Wassermann Brand of Acetazolamide
Wyeth Brand of Acetazolamide Preparation
acetazolamide
5
Propofolapproved, investigational, vet_approvedPhase 410822078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
6
Morphineapproved, investigationalPhase 4, Phase 3100757-27-25288826
Synonyms:
(-)(5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(-)-Heroin hydrochloride
(-)-Morphine
(-)Morphine sulfate
(5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diol
(5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol
(5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5alpha,6alpha)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5α,6α)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
(5α,6α)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL
(7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol
(−)-morphine
17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol
4,5alpha-Epoxy-17-methyl-7-morphinen-3,6alpha-diol
4-methyl-(13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol
47106-99-0
57-27-2
6211-15-0 (sulfate (2:1) (salt) pentahydrate)
64-31-3
64-31-3 (sulfate (2:1) (salt) anhydrous)
7,8-Didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol
7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
8053-16-5
85201-37-2
Apokyn
Astramorph PF
Avinza
BIDD:GT0147
C01516
CCRIS 5762
CHEBI:17303
CHEMBL70
CID5288826
Cube juice
D-(-)-Morphine
DB00295
DEA No. 9300
DepoDur
Depodur
Diacetylmorphine hydrochloride
Diamorphine hydrochloride
Dolcontin
Dreamer
Dulcontin
Duramorph PF
Duromorph
EINECS 200-320-2
Epimorph
HSDB 2134
Hard stuff
Heroin hydrochloride
Heroine hydrochloride
Hocus
 
Infumorph
Kadian
LS-91748
M-Eslon
M.O.S
MOI
MORPHINE SULFATE
MORPHINE, (5A,6A)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINIAN-3,6-DIOL, MORPHIUM, MORPHIA, DOLCONTIN, DUROMORPH, MORPHINA, NEPENTHE
MS Contin
MS/L
MS/S
MSIR
Meconium
MolPort-003-849-273
Morfina
Morfina [Italian]
Morphia
Morphin
Morphin [German]
Morphina
Morphina [Italian]
Morphine Extra-Forte
Morphine Forte
Morphine H.P
Morphine Sulfate
Morphine [BAN]
Morphinism
Morphinum
Morphitec
Morphium
Morpho
Moscontin
Ms Contin
Ms Emma
NSC11441
Nepenthe
O,O'-Diacetylmorphine hydrochloride
OMS Concentrate
Oramorph SR
Ospalivina
RMS
RMS Uniserts
Rescudose
Roxanol
Roxanol 100
Roxanol UD
SDZ 202-250
SDZ202-250
Statex
Statex Drops
Statex SR
UNII-76I7G6D29C
Unkie
l-Morphine
morfina
morphine
nchembio.317-comp1
nchembio.64-comp1
7
Bupivacaineapproved, investigationalPhase 412332180-92-9, 38396-39-32474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
(±)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
 
DepoBupivacaine
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
racemic bupivacaine
8
Dexmedetomidineapproved, vet_approvedPhase 459276631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
9Adrenergic AgentsPhase 45352
10Adrenergic AgonistsPhase 43027
11AnestheticsPhase 4, Phase 29596
12Neurotransmitter AgentsPhase 4, Phase 2, Phase 318340
13Hypnotics and SedativesPhase 42616
14Anesthetics, IntravenousPhase 42538
15Adrenergic alpha-AgonistsPhase 41734
16Anesthetics, GeneralPhase 42934
17Natriuretic AgentsPhase 4, Phase 31697
18AnalgesicsPhase 4, Phase 311733
19diureticsPhase 4, Phase 31418
20Carbonic Anhydrase InhibitorsPhase 4, Phase 3186
21AnticonvulsantsPhase 4, Phase 32695
22Analgesics, OpioidPhase 4, Phase 33238
23Central Nervous System DepressantsPhase 4, Phase 313403
24Peripheral Nervous System AgentsPhase 4, Phase 2, Phase 323689
25NarcoticsPhase 4, Phase 33646
26Narcotic AntagonistsPhase 4935
27Anesthetics, LocalPhase 43492
28Anti-Bacterial AgentsPhase 411226
29Antibiotics, AntitubercularPhase 47180
30Analgesics, Non-NarcoticPhase 46501
31Adrenergic alpha-2 Receptor AgonistsPhase 4980
32
DesogestrelapprovedPhase 2, Phase 38154024-22-540973
Synonyms:
(17alpha)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol
13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol
13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
54024-22-5
AC-308
AC1L24T4
AC1Q282A
C07629
C22H30O
CHEBI:4453
CHEMBL1533
CID40973
Cerazette
D017135
D02367
 
DB00304
DESOGESTREL
Desogestrel (USAN/INN)
Desogestrel [USAN:BAN:INN]
Desogestrelum
Desogestrelum [INN-Latin]
EINECS 258-929-4
HSDB 3593
LMST02030104
LS-62079
MolPort-003-846-424
NCGC00167449-01
ORG 2969
Org-2969
Org2969
Organon Brand of Desogestrel
UNII-81K9V7M3A3
ZINC04097416
alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17
desogen
33
Nitric OxideapprovedPhase 2, Phase 361710102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
34AntioxidantsPhase 2, Phase 33050
35Protective AgentsPhase 2, Phase 37443
36Contraceptives, OralPhase 2, Phase 31327
37ProgestinsPhase 2, Phase 3564
38Contraceptive AgentsPhase 2, Phase 31967
39Hormone AntagonistsPhase 2, Phase 313180
40HormonesPhase 2, Phase 314415
41Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 2, Phase 313168
42Vasodilator AgentsPhase 2, Phase 33543
43Respiratory System AgentsPhase 2, Phase 34997
44Bronchodilator AgentsPhase 2, Phase 32965
45Endothelium-Dependent Relaxing FactorsPhase 2, Phase 3281
46Anti-Asthmatic AgentsPhase 2, Phase 33488
47Autonomic AgentsPhase 2, Phase 310150
48
Dexamethasoneapproved, investigational, vet_approvedPhase 2217150-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
49Gastrointestinal AgentsPhase 28402
50
protease inhibitorsPhase 25471
Synonyms:
 
protease inhibitors

Interventional clinical trials:

(show top 50)    (show all 142)
idNameStatusNCT IDPhase
1Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory FailureUnknown statusNCT00994552Phase 4
2Non-Invasive Ventilation in Amyotrophic Lateral SclerosisUnknown statusNCT00560287Phase 4
3Treatment of High Altitude Polycythemia by AcetazolamideCompletedNCT00424970Phase 4
4Patients-ventilator Interaction During Sleep: Effect of Humidification SystemCompletedNCT01038791Phase 4
5Oral Oxycodone After Major Cardiac SurgeryCompletedNCT01816581Phase 4
6Phase 4, Controlled Study in Adult Subjects Undergoing Primary, 1-2 Level, Open Lumbar Spinal Fusion SurgeryRecruitingNCT03015961Phase 4
7Stacking Exercises Aid the Decline in FVC and Sick TimeActive, not recruitingNCT01999075Phase 4
8Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During ColonoscopyNot yet recruitingNCT03139279Phase 4
9Target Volume Mode Controlled Ventilator in Obesity Hypoventilation SyndromeSuspendedNCT01104610Phase 4
10Treatment of Metabolic Alkalosis in Acute Exacerbations of Cystic FibrosisUnknown statusNCT00163852Phase 2, Phase 3
11Assessment of Desogestrel in Ondine SyndromeCompletedNCT01243697Phase 2, Phase 3
12Using Capnography to Reduce Hypoxia During Pediatric SedationCompletedNCT01463527Phase 3
13Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.CompletedNCT01499485Phase 3
14Validation of the AVAPS AE Algorithm in Chronic Obstructive Pulmonary Disease (COPD) PatientsCompletedNCT01601977Phase 2, Phase 3
15Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study)CompletedNCT00748423Phase 2, Phase 3
16Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After AbdominoplastyCompletedNCT02820324Phase 3
17Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After BunionectomyCompletedNCT02815709Phase 3
18Cost Effectiveness of Outpatient Set-up of Automated NIV in Obese Patients With Chronic Respiratory FailureRecruitingNCT02342899Phase 3
19Patient -Ventilator Interaction in Chronic Respiratory FailureCompletedNCT01371149Phase 2
20Effectiveness of Continuous Negative External Pressure in Preventing Upper Airway Impairment During Routine ColonoscopyCompletedNCT01895062Phase 1, Phase 2
21Trial of Operative Fixation of Fractured Ribs in Patients With Flail ChestCompletedNCT00298259Phase 2
22Alternative of Treatment in Obesity Hypoventilation SyndromeRecruitingNCT01405976Phase 2
23Study to Justify Steroid Use in Preterm Neonates to Prevent Bronchopulmonary DysplasiaRecruitingNCT03035214Phase 2
24Diaphragm Pacing System (DPS) In Participants With Amyotrophic Lateral Sclerosis (ALS)Active, not recruitingNCT01938495Phase 2
25Effect of Air-stacking on Peak Cough Flow in Patients With Acute Cervical or High Thoracic Spinal Cord InjuryWithdrawnNCT01046175Phase 2
26Telemedicine and Ventilator Titration in Chronic Respiratory Patients Initiating Non-invasive VentilationUnknown statusNCT01560741Phase 1
27AutoVPAP Versus VPAP; Assessment of Sleep and VentilationCompletedNCT00252252Phase 1
28EIT Study With Healthy PatientsCompletedNCT02828007Phase 1
29PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to AdulthoodUnknown statusNCT00652964
30Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation SyndromeUnknown statusNCT01500473
31Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB -Unknown statusNCT02021448
32Obesity Hypoventilation Syndrome Prevalence StudyUnknown statusNCT01964339
33Use of Polysomnography for Non-Invasive Ventilation Settings' OptimizationUnknown statusNCT00603096
34Factors Associated With Chronic Respiratory Failure in ObesityUnknown statusNCT01380418
35Spirometric Detection of Esophageal IntubationUnknown statusNCT02052869
36Systematic Follow-up of Patients Surviving an Episode of Acute Hypercapnic Respiratory Failure in the ICUUnknown statusNCT02111876
37Opiate Sleep Disordered Breathing StudyUnknown statusNCT00791674
38Cardiovascular Consequences of NIV Withdrawal in Patients With Myotonic DystrophyUnknown statusNCT00745238
39Breathing Training for AsthmaUnknown statusNCT00975273
40Changes in Spontaneous Ventilation in Response to Changes in Extracorporeal Carbon Dioxide RemovalUnknown statusNCT01953484
41Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory FailureUnknown statusNCT01174316
42Chronic Mountain Sickness, Systemic Vascular FunctionUnknown statusNCT01182792
43A Study to Investigate the Effects of Heated Humidification During Non-Invasive VentilationUnknown statusNCT01372072
44Adaptive Servo Ventilation (ASV) in Heart FailureUnknown statusNCT02440971
45Late-onset Congenital Central Hypoventilation Syndrome and the Mutation of Phox2B GeneCompletedNCT01225679
46Ketamine Infusion and HypoventilationCompletedNCT01535976
47Prevalence of Obesity Hypoventilation SyndromeCompletedNCT01903135
48Capnography Monitoring in the Bronchoscopic SedationCompletedNCT02848118
49A Comparison of the Detection of Hypoventilation During Deep Sedation Utilizing Nasal End Title CO@ Versus Transcutaneous CO2 Measurement TechniquesCompletedNCT00954733
50The Obesity-hypoventilation Syndrome Study of Clinical Characteristics and Predictive Factors of Response to TreatmentCompletedNCT00938977

Search NIH Clinical Center for Central Hypoventilation Syndrome, Congenital

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: hypoventilation

Genetic Tests for Central Hypoventilation Syndrome, Congenital

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Genetic tests related to Central Hypoventilation Syndrome, Congenital:

id Genetic test Affiliating Genes
1 Congenital Central Hypoventilation27
2 Haddad Syndrome27
3 Central Hypoventilation27
4 Congenital Central Hypoventilation Syndrome24 ASCL1, BDNF, EDN3, GDNF, PHOX2B

Anatomical Context for Central Hypoventilation Syndrome, Congenital

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MalaCards organs/tissues related to Central Hypoventilation Syndrome, Congenital:

36
Lung, Skin, Heart, Brain, Eye

Publications for Central Hypoventilation Syndrome, Congenital

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Variations for Central Hypoventilation Syndrome, Congenital

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UniProtKB/Swiss-Prot genetic disease variations for Central Hypoventilation Syndrome, Congenital:

70
id Symbol AA change Variation ID SNP ID
1BDNFp.Thr2IleVAR_018260rs8192466
2PHOX2Bp.Arg141GlnVAR_046900
3PHOX2Bp.Gln143ArgVAR_046901
4RETp.Arg67HisVAR_018153rs192489011
5RETp.Arg114HisVAR_018154rs76397662
6RETp.Ala432GluVAR_018155rs552057730
7RETp.Pro1039LeuVAR_018157rs79853121

Clinvar genetic disease variations for Central Hypoventilation Syndrome, Congenital:

5 (show all 11)
id Gene Variation Type Significance SNP ID Assembly Location
1EDN3EDN3, 1-BP INSinsertionPathogenic
2BDNFNM_ 170731.4(BDNF): c.29C> T (p.Thr10Ile)SNVPathogenicrs8192466GRCh37Chr 11, 27680107: 27680107
3ASCL1NM_ 004316.3(ASCL1): c.52C> A (p.Pro18Thr)SNVPathogenicrs267606667GRCh37Chr 12, 103352074: 103352074
4ASCL1ASCL1, 15-BP DEL, NT111deletionPathogenic
5ASCL1ASCL1, 24-BP DEL, NT108deletionPathogenic
6PMPCANM_ 015160.2(PMPCA): c.1129G> A (p.Ala377Thr)SNVPathogenicrs753611141GRCh38Chr 9, 136418847: 136418847
7PMPCANM_ 015160.2(PMPCA): c.1066G> A (p.Gly356Ser)SNVPathogenicrs768643552GRCh37Chr 9, 139313082: 139313082
8PHOX2BNP_ 003915.2: p.Ala260(5_ 9)NT expansionPathogenic
9PHOX2BNM_ 003924.3(PHOX2B): c.618dupC (p.Ser207Glnfs)duplicationPathogenicrs587776626GRCh37Chr 4, 41748151: 41748151
10PHOX2BPHOX2B, 37-BP DEL, NT722deletionPathogenic
11GDNFNM_ 000514.3(GDNF): c.277C> T (p.Arg93Trp)SNVrisk factorrs36119840GRCh37Chr 5, 37816112: 37816112

Expression for genes affiliated with Central Hypoventilation Syndrome, Congenital

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Search GEO for disease gene expression data for Central Hypoventilation Syndrome, Congenital.

Pathways for genes affiliated with Central Hypoventilation Syndrome, Congenital

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Pathways related to Central Hypoventilation Syndrome, Congenital according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8ASCL1, RET, TH
29.6ASCL1, PHOX2B, TLX2
39.5ASCL1, BDNF, GDNF, TH
48.5ASCL1, BDNF, PHOX2A, PHOX2B, RET, TH

GO Terms for genes affiliated with Central Hypoventilation Syndrome, Congenital

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Biological processes related to Central Hypoventilation Syndrome, Congenital according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1glial cell differentiationGO:001000110.8ASCL1, PHOX2B
2dopaminergic neuron differentiationGO:007154210.7PHOX2A, PHOX2B
3melanocyte differentiationGO:003031810.7EDN3, EDNRB
4noradrenergic neuron developmentGO:000335810.7ASCL1, PHOX2B
5noradrenergic neuron differentiationGO:000335710.6PHOX2A, PHOX2B
6posterior midgut developmentGO:000749710.6EDNRB, RET
7parasympathetic nervous system developmentGO:004848610.6PHOX2A, PHOX2B
8peripheral nervous system developmentGO:000742210.6EDNRB, GDNF
9sympathetic ganglion developmentGO:006154910.5ASCL1, PHOX2B
10response to painGO:004826510.4EDNRB, RET
11neuron fate specificationGO:004866510.4ASCL1, TLX3
12negative regulation of neuron differentiationGO:004566510.3ASCL1, PHOX2B, TLX3
13regulation of respiratory gaseous exchange by neurological system processGO:000208710.2PHOX2B, TLX3
14neuron migrationGO:000176410.2ASCL1, PHOX2B, TLX3
15neural crest cell migrationGO:000175510.2EDN3, EDNRB, GDNF, RET
16regulation of gene expressionGO:001046810.1ASCL1, EDN3, GDNF, PHOX2B
17vasoconstrictionGO:004231010.0EDN3, EDNRB
18nervous system developmentGO:000739910.0ASCL1, BDNF, EDNRB, GDNF, RET
19vein smooth muscle contractionGO:001482610.0EDN3, EDNRB
20sympathetic nervous system developmentGO:00484859.9ASCL1, GDNF, PHOX2A, PHOX2B
21enteric nervous system developmentGO:00484849.8EDNRB, GDNF, PHOX2B, RET, TLX2
22neuron differentiationGO:00301829.8ASCL1, EDN3, PHOX2B, RET, TLX3
23multicellular organism developmentGO:00072758.9ASCL1, DBX1, EDN3, PHOX2B, TLX2, TLX3

Molecular functions related to Central Hypoventilation Syndrome, Congenital according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:00435658.1ASCL1, DBX1, PHOX2A, PHOX2B, TLX2, TLX3

Sources for Central Hypoventilation Syndrome, Congenital

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet