Central Nervous System Cancer malady

Wikipedia: A brain tumor, or tumour, is an intracranial solid neoplasm, a tumor (defined as an abnormal growth of...⁴⁴ more...

MalaCards: Central Nervous System Cancer, also known as malignant neoplasm of central nervous system, unspecified (disorder), is related to neuroectodermal tumors and malignant glioma. An important gene associated with Central Nervous System Cancer is ARSA (arylsulfatase A). The drugs prednisone and prednisolone tebutate and the compound oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system and brain, and related mouse phenotypes are tumorigenesis and immune system.

Disease Ontology: A nervous system cancer that is located in the central nervous system.⁶

Aliases & Descriptions:

central nervous system cancer 6 8 32 malignant neoplasm of central nervous system, unspecified (disorder) 6 malignant neoplasm of central nervous system (disorder) 6 malignant neoplasm of central nervous system, nos 6 malignant neoplasm of central nervous system nos 6 neoplasm of central nervous system (disorder) 6 malignant neoplasm of central nervous system 43

central nervous system neoplasms 43 central nervous system tumors 6 central nervous system tumor 6 malignant tumor of cns 6 malignant neoplasms 43 cns neoplasm 6 neoplasms 43

Diseases related to central nervous system cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 911)

id	Related Disease	Score	Top Affiliating Genes
1	neuroectodermal tumors	28.3	EWSR1, FLI1, CD99
2	malignant glioma	27.5	CD99, FLI1, EWSR1, SHH
3	anaplastic large cell lymphoma	27.2	CD99, SHH
4	embryonal cancer	26.8	CD99, FLI1
5	b-cell lymphomas	26.2	CD99, FLI1, SHH
6	breast cancer	26.2	SHH, EWSR1, ARSA, FLI1, CD99
7	melanoma	25.9	CD99, FLI1, EWSR1, SHH
8	lymphoblastic leukemia	25.0	CD99, FLI1, SHH
9	liposarcoma	24.9	EWSR1, FLI1
10	synovial sarcoma	24.4	CD99, FLI1, EWSR1
11	acute lymphoblastic leukemia	24.4	CD99, FLI1, SHH
12	bladder sarcoma	24.1	CD99, FLI1
13	peripheral primitive neuroectodermal tumor	23.8	FLI1, EWSR1
14	rhabdomyosarcoma	23.0	CD99, FLI1, EWSR1
15	chondrodysplasia punctata	12.8	ARSA, CD99
16	extraosseous ewing's sarcoma	12.7	EWSR1, CD99
17	chondrodysplasia	12.7	ARSA, CD99
18	germ cell cancer	12.6	EWSR1, SHH
19	fibrous histiocytoma	12.4	CD99, EWSR1
20	esthesioneuroblastoma	12.4	FLI1, CD99
21	lymphoblastic lymphoma	12.4	FLI1, CD99
22	histiocytoma	12.2	EWSR1, CD99
23	desmoplastic small round cell tumor	11.9	EWSR1, FLI1, CD99
24	neuroepithelioma	11.9	CD99, FLI1, EWSR1
25	cerebral primitive neuroectodermal tumor	11.8	EWSR1, FLI1, CD99
26	pediatric central nervous system tumor	9.6
27	thyroiditis	9.5
28	carcinoma	9.2
29	pancreatitis	9.0
30	tongue cancer	7.9
31	liver cancer	7.8
32	adenocarcinoma	7.7
33	lip cancer	7.6
34	colonic neoplasm	7.5
35	nasopharynx carcinoma	7.4
36	lung neoplasm	7.4
37	cervicitis	7.3
38	brain cancer	7.2
39	esophageal cancer	7.1
40	intraepithelial neoplasm	7.1
41	stomach cancer	7.1
42	thyroid cancer	7.1
43	meningioma	7.1
44	meningitis	7.0
45	neuronitis	7.0
46	oligodendroglioma	7.0
47	primitive neuroectodermal tumor	7.0
48	tuberous sclerosis	7.0
49	hyperprolactinemia	7.0
50	leukemia	7.0

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carboplatin, dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to central nervous system cancer:

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FMA organs/tissues related to central nervous system cancer:

¹¹

MGI Mouse Phenotypes related to central nervous system cancer:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	tumorigenesis	MP:0002006	8.2	FLI1, EWSR1, SHH
2	immune system phenotype	MP:0005387	8.1	FLI1, ARSA, EWSR1, SHH

Genes related to central nervous system cancer according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	ARSA	arylsulfatase A	11.0
2	CD99	CD99 molecule	11.0
3	EWSR1	Ewing sarcoma breakpoint region 1	11.0
4	FLI1	Friend leukemia virus integration 1	11.0
5	SHH	sonic hedgehog	11.0

Compounds related to central nervous system cancer according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	oligonucleotide32	8.6	FLI1, ARSA, EWSR1