MCID: CNT033
MIFTS: 38

Central Nervous System Cancer malady

Neuronal diseases, Cancer diseases categories

Summaries for Central Nervous System Cancer

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A nervous system cancer that is located in the central nervous system.

MalaCards: Central Nervous System Cancer, also known as malignant neoplasm of central nervous system, is related to leukemia and nervous system cancer. An important gene associated with Central Nervous System Cancer is ARSA (arylsulfatase A). The drug carboplatin and the compounds askin and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system, breast and brain.

Aliases & Classifications for Central Nervous System Cancer

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

central nervous system cancer 8 10 44
malignant neoplasm of central nervous system 8 60
malignant neoplasm of central nervous system, unspecified 8
malignant neoplasm of central nervous system, nos 8
malignant neoplasm of central nervous system nos 8
neoplasm of central nervous system 8
central nervous system neoplasms 60
central nervous system tumors 8
central nervous system tumor 8
malignant tumor of cns 8
cns neoplasm 8


External Ids:

Disease Ontology8 DOID:3620
MeSH34 D016543
NCIt39 C9293

Related Diseases for Central Nervous System Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Central Nervous System Cancer family:

Nervous System Cancer

Diseases related to Central Nervous System Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.3FLI1, EWSR1, CD99
2nervous system cancer10.6
3brain cancer10.4
4central nervous system leukemia10.3
5central nervous system hematologic cancer10.2
6encephalomyelitis10.1
7spinal cancer10.1
8glioma somatic10.1
9astrocytoma10.1
10brucellosis10.1
11medulloblastoma10.1
12meningioma10.1
13tuberous sclerosis10.1
14hyperprolactinemia10.1
15neuronitis10.1
16central nervous system disease10.1
17childhood leukemia10.1
18malignant glioma10.1
19meningitis10.1
20nervous system disease10.1
21oligodendroglioma10.1
22mowat-wilson syndrome10.1
23turcot syndrome10.1
24esophageal atresia10.0SHH
25fibrous histiocytoma10.0EWSR1
26anaplastic large cell lymphoma10.0ENO2
27ganglioneuroma10.0ENO2
28gastrinoma10.0ENO2
29breast cancer10.0FLI1, ARSA
30extraskeletal ewing sarcoma10.0EWSR1, CD99
31connective tissue benign neoplasm10.0EWSR1, FLI1
32merkel cell carcinoma10.0ENO2
33retinoblastoma10.0ENO2
34prostate cancer10.0ENO2, FLI1
35teratoma10.0CD99, ENO2
36synovial sarcoma10.0FLI1, EWSR1, CD99
37olfactory neuroblastoma10.0FLI1, CD99, ENO2
38lymphoblastic lymphoma10.0ENO2, CD99, FLI1
39neuroepithelioma10.0ENO2, EWSR1, FLI1
40melanoma10.0FLI1, ENO2, EWSR1
41wilms tumor10.0EWSR1, ENO2, FLI1
42burkitt's lymphoma10.0CD99, FLI1, ENO2
43cerebritis10.0
44cerebral amyloid angiopathy10.0
45peripheral primitive neuroectodermal tumor10.0EWSR1, ENO2, CD99, FLI1
46cerebral primitive neuroectodermal tumor10.0ENO2, CD99, FLI1, EWSR1
47rhabdomyosarcoma10.0ENO2, FLI1, CD99, EWSR1
48sarcoma10.0CD99, EWSR1, FLI1, ENO2

Graphical network of the top 20 diseases related to Central Nervous System Cancer:



Diseases related to central nervous system cancer

Clinical Features for Central Nervous System Cancer

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Drugs & Therapeutics for Central Nervous System Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Central Nervous System Cancer

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Cancer

Search NIH Clinical Center for Central Nervous System Cancer

Search CenterWatch for Central Nervous System Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Central Nervous System Cancer

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Anatomical Context for Central Nervous System Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Central Nervous System Cancer:

32
Breast, Brain, Lung, Endothelial

FMA organs/tissues related to Central Nervous System Cancer:

14
The central nervous system

Animal Models for Central Nervous System Cancer or affiliated genes

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Publications for Central Nervous System Cancer

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Sources:
50PubMed
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Articles related to Central Nervous System Cancer:

(show all 41)
idTitleAuthorsYear
1
The Central Nervous System as a Sanctuary Site in ALK-Positive Non-Small-Cell Lung Cancer. (24389440)
2013
2
Beneath the Blood Brain Barrier: The Challenge of Diagnosis and Management of Central Nervous System Involvement in ALK-Positive Lung Cancer. (24389428)
2013
3
Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients. (23661397)
2013
4
Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival. (23235554)
2013
5
Medulloblastoma and Brucellosis - Molecular Evidence of Brucella sp in Association with Central Nervous System Cancer. (21475718)
2011
6
ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells. (21165575)
2011
7
Comparison of time trends in brain and central nervous system cancer mortality (1990-2006) between countries based on the WHO mortality database. (21273379)
2011
8
Influence of 6q22-23 on overall survival in primary central nervous system lymphoma. Analysis of North Central Cancer Treatment Group trials 86 72 52, 93 73 51 and 96 73 51. (21275973)
2011
9
Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib. (21030498)
2010
10
Long-term health experience of jet engine manufacturing workers: IV. A comparison of central nervous system cancer ascertainment using mortality and incidence data. (20816315)
2010
11
Pain in children with central nervous system cancer: a review of the literature. (20591796)
2010
12
Characteristics and outcomes of elderly patients with primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center experience. (20572045)
2010
13
School-aged children after the end of successful treatment of non-central nervous system cancer: longitudinal assessment of health-related quality of life, anxiety and coping. (19594611)
2009
14
Differential N-glycosylation of kallikrein 6 derived from ovarian cancer cells or the central nervous system. (19088065)
2009
15
Human epidermal growth factor receptor 2-positive breast cancer and central nervous system metastases. (19770385)
2009
16
An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016). (19056914)
2009
17
Comparison of time trends in brain central nervous system cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vols IV-VIII. (18772173)
2008
18
Neuropsychological sequelae of non-central nervous system cancer and cancer therapy. (18415683)
2008
19
Risk factors for central nervous system metastasis in patients with metastatic breast cancer. (17848738)
2007
20
Primary breast cancer phenotypes associated with propensity for central nervous system metastases. (16826579)
2006
21
Whole-brain radiotherapy and high-dose methylprednisolone for elderly patients with primary central nervous system lymphoma: Results of North Central Cancer Treatment Group (NCCTG) 96-73-51. (16863926)
2006
22
Primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center prognostic model. (17116938)
2006
23
The treatment of primary central nervous system lymphoma in 122 immunocompetent patients: a population-based study of successively treated cohorts from the British Colombia Cancer Agency. (15651059)
2005
24
Central nervous system metastases in breast cancer patients administered trastuzumab. (15979804)
2005
25
Epidermal growth factor receptor status in breast cancer metastases to the central nervous system. Comparison with HER-2/neu status. (15335267)
2004
26
Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells. (15194216)
2004
27
Central nervous system listeriosis confused with leptomeningeal carcinomatosis in cancer patients. (15057164)
2004
28
Pyridoxal phosphatase is a novel cancer autoantigen in the central nervous system. (15452547)
2004
29
Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. (12853349)
2003
30
Her-2/neu status in breast cancer metastases to the central nervous system. (14567724)
2003
31
High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962. (14597741)
2003
32
German Cancer Society Neuro-Oncology Working Group NOA-03 multicenter trial of single-agent high-dose methotrexate for primary central nervous system lymphoma. (11835382)
2002
33
Exploitation of immune mechanisms in the treatment of central nervous system cancer. (10914414)
2000
34
Endocrine mechanism of action of toremifene at the level of the central nervous system in advanced breast cancer patients. (9685060)
1998
35
Stiff-man syndrome in a woman with breast cancer: an uncommon central nervous system paraneoplastic syndrome. (9443464)
1998
36
Craniospinal irradiation for acute lymphoblastic leukemia with central nervous system disease at diagnosis: a report from the Children's Cancer Group. (8823255)
1996
37
Diagnostic value of cerebrospinal fluid cytology in comparison with tumor marker activity in central nervous system metastases secondary to breast cancer. (8402452)
1993
38
Human malignant astrocytoma xenografts migrate in rat brain: a model for central nervous system cancer research. (2651679)
1989
39
Human retrovirus family: cancer, central nervous system disease, and AIDS. (2842514)
1988
40
Brain and central nervous system cancer mortality in U. S. rubber workers. (6953785)
1982
41
The increasing incidence of central nervous system leukemia in children. (Children's Cancer Study Group A). (5271211)
1970

Genetic Variations for Central Nervous System Cancer

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Expression for genes affiliated with Central Nervous System Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Cancer

Search GEO for disease gene expression data for Central Nervous System Cancer.

Pathways for genes affiliated with Central Nervous System Cancer

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Compounds for genes affiliated with Central Nervous System Cancer

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44Novoseek
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Compounds related to Central Nervous System Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1askin449.2EWSR1, ENO2
2oligonucleotide449.0EWSR1, ARSA, FLI1
3ganglioside448.9ENO2, ARSA
4glutamine448.6EWSR1, ARSA, ENO2
5paraffin448.5ENO2, CD99, EWSR1

GO Terms for genes affiliated with Central Nervous System Cancer

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16Gene Ontology
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Cellular components related to Central Nervous System Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.6ENO2, CD99, SHH, ARSA, EWSR1

Products for genes affiliated with Central Nervous System Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Nervous System Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet