MCID: CNT033
MIFTS: 35

Central Nervous System Cancer malady

Neuronal diseases, Cancer diseases categories

Summaries for Central Nervous System Cancer

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Sources:
9Disease Ontology, 34MalaCards
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Disease Ontology:9 A nervous system cancer that is located in the central nervous system.

MalaCards: Central Nervous System Cancer, also known as malignant neoplasm of central nervous system, is related to nervous system cancer and endotheliitis. An important gene associated with Central Nervous System Cancer is ARSA (arylsulfatase A), and among its related pathways is Metabolism. The drug carboplatin and the compounds ganglioside and glutamine have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system and brain.

Aliases & Classifications for Central Nervous System Cancer

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

central nervous system cancer 9 11 46
malignant neoplasm of central nervous system 9 63
malignant neoplasm of central nervous system, unspecified 9
malignant neoplasm of central nervous system, nos 9
malignant neoplasm of central nervous system nos 9
neoplasm of central nervous system 9
central nervous system neoplasms 63
central nervous system tumors 9
central nervous system tumor 9
malignant tumor of cns 9
cns neoplasm 9


External Ids:

Disease Ontology9 DOID:3620
NCIt41 C9293
MeSH36 D016543

Related Diseases for Central Nervous System Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Central Nervous System Cancer family:

Nervous System Cancer

Diseases related to Central Nervous System Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 20)
idRelated DiseaseScoreTop Affiliating Genes
1nervous system cancer10.7
2endotheliitis10.4
3central nervous system hematologic cancer10.3
4leukemia10.3
5neuronitis10.1
6tuberous sclerosis10.1
7hyperprolactinemia10.1
8childhood leukemia10.1
9malignant glioma10.1
10meningitis10.1
11oligodendroglioma10.1
12mowat-wilson syndrome10.1
13turcot syndrome10.1
14astrocytoma10.1
15brucellosis10.1
16medulloblastoma10.1
17meningioma10.1
18cerebral amyloid angiopathy10.0
19cerebritis10.0
20anaplastic astrocytoma10.0

Graphical network of diseases related to Central Nervous System Cancer:



Diseases related to central nervous system cancer

Symptoms for Central Nervous System Cancer

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Drugs & Therapeutics for Central Nervous System Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Central Nervous System Cancer

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Cancer

Search NIH Clinical Center for Central Nervous System Cancer

Search CenterWatch for Central Nervous System Cancer

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Central Nervous System Cancer

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Anatomical Context for Central Nervous System Cancer

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Central Nervous System Cancer:

34
Brain

FMA organs/tissues related to Central Nervous System Cancer:

15
The central nervous system

Animal Models for Central Nervous System Cancer or affiliated genes

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Publications for Central Nervous System Cancer

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Sources:
53PubMed
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Articles related to Central Nervous System Cancer:

(show all 12)
idTitleAuthorsYear
1
Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients. (23661397)
2013
2
Medulloblastoma and Brucellosis - Molecular Evidence of Brucella sp in Association with Central Nervous System Cancer. (21475718)
2011
3
Comparison of time trends in brain and central nervous system cancer mortality (1990-2006) between countries based on the WHO mortality database. (21273379)
2011
4
Long-term health experience of jet engine manufacturing workers: IV. A comparison of central nervous system cancer ascertainment using mortality and incidence data. (20816315)
2010
5
Pain in children with central nervous system cancer: a review of the literature. (20591796)
2010
6
School-aged children after the end of successful treatment of non-central nervous system cancer: longitudinal assessment of health-related quality of life, anxiety and coping. (19594611)
2009
7
Comparison of time trends in brain central nervous system cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vols IV-VIII. (18772173)
2008
8
Neuropsychological sequelae of non-central nervous system cancer and cancer therapy. (18415683)
2008
9
Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells. (15194216)
2004
10
Exploitation of immune mechanisms in the treatment of central nervous system cancer. (10914414)
2000
11
Human malignant astrocytoma xenografts migrate in rat brain: a model for central nervous system cancer research. (2651679)
1989
12
Brain and central nervous system cancer mortality in U. S. rubber workers. (6953785)
1982

Variations for Central Nervous System Cancer

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Expression for genes affiliated with Central Nervous System Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Cancer

Search GEO for disease gene expression data for Central Nervous System Cancer.

Pathways for genes affiliated with Central Nervous System Cancer

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Sources:
51PathCards, 56Reactome, 31KEGG
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Pathways related to Central Nervous System Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ARSA, ENO2

Compounds for genes affiliated with Central Nervous System Cancer

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Sources:
46Novoseek, 25HMDB, 12DrugBank
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Compounds related to Central Nervous System Cancer according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1ganglioside469.4ARSA, ENO2
2glutamine469.4ARSA, ENO2
3lactate469.3ENO2, ARSA
4creatinine469.3ARSA, ENO2
5aspartate469.3ENO2, ARSA
6leucine469.2ENO2, ARSA
7magnesium46 25 1211.2ARSA, ENO2
8Water259.1ARSA, ENO2
9tyrosine469.1ARSA, ENO2
10alanine469.0ENO2, ARSA
11lipid468.8ARSA, ENO2

GO Terms for genes affiliated with Central Nervous System Cancer

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Sources:
17Gene Ontology
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Cellular components related to Central Nervous System Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1ARSA, ENO2

Biological processes related to Central Nervous System Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442819.1ARSA, ENO2

Products for genes affiliated with Central Nervous System Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Nervous System Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet