CNS
MCID: CNT035
MIFTS: 49

Central Nervous System Disease (CNS) malady

Neuronal diseases, Immune diseases categories
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Summaries for Central Nervous System Disease

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.

MalaCards: Central Nervous System Disease, also known as CNS, is related to multiple sclerosis and subacute sclerosing panencephalitis. An important gene associated with Central Nervous System Disease is MOG (myelin oligodendrocyte glycoprotein). The compounds oleic acid and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related mouse phenotype endocrine/exocrine gland.

Wikipedia:65 The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal... more...

Aliases & Classifications for Central Nervous System Disease

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Sources:
8Disease Ontology, 39NCBI Bookshelf, 58SNOMED-CT, 35MeSH, 62UMLS, 40NCIt, 25ICD10
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Related Diseases for Central Nervous System Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Autoimmune Disease of the Nervous System
central nervous system disease Congenital Nervous System Abnormality

Diseases related to Central Nervous System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 497)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis30.5GC, MOG, CD46
2subacute sclerosing panencephalitis30.3MOG, CD46
3encephalitis30.3MOG, CD46
4astrocytoma29.9CD46, CHRM1
5schizophrenia29.9PICK1, MOG, CHRM1
6nervous system disease11.3
7systemic lupus erythematosus10.6
8lupus erythematosus10.6
9leukemia10.5
10measles10.5
11lymphocytic choriomeningitis10.5
12encephalomyelitis10.5
13langerhans-cell histiocytosis10.4
14histiocytosis10.4
15pneumonia10.4
16germinoma10.4
17siderosis10.4
18stomatitis10.4
19lymphomatoid granulomatosis10.3
20kaposi's sarcoma10.3
21cerebritis10.3
22acute myeloid leukemia10.3
23herpes simplex10.3
24lymphoblastic leukemia10.3
25myeloid leukemia10.3
26sarcoma10.3
27hematopoietic stem cell transplantation10.3
28meningitis10.3
29superficial siderosis10.3
30b-cell lymphomas10.3
31germ cell tumors10.2
32neuronitis10.2
33acquired immunodeficiency syndrome10.2
34mumps10.2
35hepatitis10.2
36hodgkin's lymphoma10.2
37neuropathy10.2
38retinitis10.2
39vasculitis10.2
40hiv-110.2
41granulomatous angiitis10.2
42wallerian degeneration10.2
43atypical teratoid rhabdoid tumor10.2
44alzheimer's disease10.2
45melanoma10.2
46neuronal ceroid lipofuscinosis10.2
47primitive neuroectodermal tumor10.2
48whipple disease10.1
49hydrocephalus10.1
50trypanosomiasis10.1

Graphical network of the top 20 diseases related to Central Nervous System Disease:



Diseases related to central nervous system disease

Symptoms for Central Nervous System Disease

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Drugs & Therapeutics for Central Nervous System Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Central Nervous System Disease

Search NIH Clinical Center for Central Nervous System Disease

Genetic Tests for Central Nervous System Disease

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Anatomical Context for Central Nervous System Disease

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33MalaCards
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MalaCards organs/tissues related to Central Nervous System Disease:

33
Brain, Spinal cord, T cells, Testes, Myeloid, Bone marrow, Skin, Liver, Kidney, Bone, Pituitary

Animal Models for Central Nervous System Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Central Nervous System Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.8GC, CHRM1, PICK1

Publications for Central Nervous System Disease

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Sources:
52PubMed
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Articles related to Central Nervous System Disease:

(show top 50)    (show all 266)
idTitleAuthorsYear
1
Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease. (21692072)
2012
2
Post-transplant lymphoproliferative disorder: the significance of central nervous system disease. (22717024)
2012
3
Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. (21387369)
2011
4
Screening for central nervous system disease in metastatic gestational trophoblastic neoplasia. (20795342)
2010
5
Significance of surface epithelial cells in canine cerebrospinal fluid and relationship to central nervous system disease. (20727124)
2010
6
Neural progenitors and HIV-1-associated central nervous system disease in adults and children. (16842084)
2006
7
PPARgamma as a therapeutic target in central nervous system diseases. (16766086)
2006
8
Disseminating anaplastic brainstem oligodendroglioma associated with allelic loss in the tumor suppressor candidate region D19S246 of chromosome 19 mimicking an inflammatory central nervous system disease in a 9-year-old boy. (16084959)
2005
9
Central nervous system disease in primary Sjogrens syndrome: the role of magnetic resonance imaging. (15609267)
2004
10
Update on neuroimaging in infectious central nervous system disease. (15247545)
2004
11
Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells. (15470017)
2004
12
Concurrent syrinx and inflammatory central nervous system disease detected by magnetic resonance imaging: an illustrative case and review of the literature. (11807404)
2002
13
A novel simian immunodeficiency virus model that provides insight into mechanisms of human immunodeficiency virus central nervous system disease. (12491150)
2002
14
Laboratory diagnosis of human cytomegalovirus (HCMV) central nervous system disease in AIDS patients. (11118856)
2000
15
The clinical relevance of antibodies to ribosomal-P common epitope in two targeted systemic lupus erythematosus populations: a large cohort of consecutive patients and patients with active central nervous system disease. (10666163)
2000
16
Cloning the antibody response in humans with inflammatory central nervous system disease: analysis of the expressed IgG repertoire in subacute sclerosing panencephalitis brain reveals disease-relevant antibodies that recognize specific measles virus antigens. (10477623)
1999
17
Primary SjAPgren's syndrome with severe central nervous system disease. (10468410)
1999
18
Possible concomitant fibromyalgia in systemic lupus erythematosus patients with overt central nervous system disease but with cognitive deficits: comment on the article by Kozora et al. (9259439)
1997
19
Gene transfer and delivery in central nervous system disease. (15104414)
1997
20
Analysis of cognitive and psychological deficits in systemic lupus erythematosus patients without overt central nervous system disease. (8961909)
1996
21
Association of antiphospholipid antibodies with central nervous system disease in systemic lupus erythematosus. (7573096)
1995
22
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
23
Cerebrospinal fluid analysis in systemically ill children without central nervous system disease. (7596721)
1995
24
The significance of in-situ Ia antigen expression in the pathogenesis of autoimmune central nervous system disease. (8397714)
1993
25
Capillary-zone electrophoretic analyses of the proteins and amino acid components in cerebrospinal fluid of central nervous system diseases. (8287042)
1993
26
Central nervous system disease in acute lymphoblastic leukemia. (8443045)
1993
27
Amyloid in central nervous system disease. (1963819)
1990
28
Beta-endorphin alters the course of central nervous system disease induced by a temperature-sensitive vesicular stomatitis virus in reconstituted nude mice. (2160476)
1990
29
Anaesthesia and central nervous system disease in small animals. Part II: Anaesthetic management for specific diseases and procedures. (2204465)
1990
30
Beta-endorphin alters a viral induced central nervous system disease in normal mice but not in nude mice. (2553770)
1989
31
Central nervous system disease: a dental diagnosis? (3268641)
1988
32
Cyclic esotropia with central nervous system disease: report of two cases. (3681610)
1987
33
Central nervous system disease in renal transplant recipients. (3309697)
1987
34
Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease. (6265583)
1981
35
Raccoon ascarid larvae as a cause of fatal central nervous system disease in subhuman primates. (7199033)
1981
36
Blunted TSH response to TRH in patients with central nervous system disease. (6787920)
1981
37
Central nervous system disease. (509758)
1979
38
Some electronystagmographic manifestations of central nervous system disease. (1083180)
1976
39
The effect of neonatal thymectomy on Tamiami virus-induced central nervous system disease. (1123649)
1975
40
Bromide partition test in the evaluation of the blood-cerebrospinal barrier in children with congenital hypothyroidism and central nervous system disease. (1224969)
1975
41
Hyponatremia and central nervous system disease. (4154911)
1974
42
Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. (4561841)
1972
43
Autokinesis and central nervous system disease. (5131768)
1971
44
Chalasia, peptic esophagitis, and hiatal hernia. A common syndrome in patients with central nervous system disease. (5119882)
1971
45
Vaccination with measles and central nervous system disease. (5688849)
1968
46
Response to dexamethasone suppression in central nervous system disease. (5904545)
1966
47
Thrombocytosis, central nervous system disease, and myocardial infarction pattern in infancy. (5922179)
1966
48
WILSON'S DISEASE, AN INBORN ERROR OF METABOLISM AND A MODEL OF DEGENERATIVE CENTRAL NERVOUS SYSTEM DISEASE. (14156393)
1964
49
DEMYELINATING CENTRAL NERVOUS SYSTEM DISEASE, MACULAR ATROPHY AND ACANTHOCYTOSIS (BASSEN-KORNZWEIG SYNDROME). (14237436)
1964
50
SKIN REACTION IN CHILDREN AND ADULTS WITH CENTRAL NERVOUS SYSTEM DISEASE AFTER INTRACUTANEOUS ADMINISTRATION OF MYELIN PREPARATIONS DERIVED FROM HUMAN BRAIN. (14054526)
1963

Variations for Central Nervous System Disease

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Expression for genes affiliated with Central Nervous System Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Disease

Search GEO for disease gene expression data for Central Nervous System Disease.

Pathways for genes affiliated with Central Nervous System Disease

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Compounds for genes affiliated with Central Nervous System Disease

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Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB
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Compounds related to Central Nervous System Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oleic acid45 29 24 1112.6GC, MOG
2acetylcholine45 51 29 24 1113.2MOG, CHRM1
3sialic acid459.0CD46, GC
4glutamate458.8CHRM1, GC, PICK1
5nitric oxide45 24 1110.7CHRM1, MOG, CD46
6lipid458.5GC, CHRM1, PICK1, MOG
7tyrosine458.5CHRM1, PICK1, CD46
8serine458.2GC, MOG, PICK1, CD46
9calcium45 51 24 1110.7CD46, GC, MOG, CHRM1, PICK1

GO Terms for genes affiliated with Central Nervous System Disease

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16Gene Ontology
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Cellular components related to Central Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic densityGO:0140699.2CHRM1, PICK1
2postsynaptic membraneGO:0452119.0CHRM1, PICK1
3plasma membraneGO:0058868.1CD46, MOG, CHRM1, PICK1

Biological processes related to Central Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.3CHRM1, PICK1

Products for genes affiliated with Central Nervous System Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Nervous System Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet