CNS
MCID: CNT035
MIFTS: 60

Central Nervous System Disease (CNS) malady

Neuronal diseases category

Summaries for Central Nervous System Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.

MalaCards: Central Nervous System Disease, also known as CNS, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Central Nervous System Disease is CHRM1 (cholinergic receptor, muscarinic 1), and among its related pathways are GPCRs, Other and Calcium signaling pathway. The compounds Hyoscyamine and 4-damp have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related mouse phenotypes are vision/eye and muscle.

Wikipedia:63 The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal... more...

Aliases & Classifications for Central Nervous System Disease

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8Disease Ontology, 38NCBI Bookshelf, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Central Nervous System Disease

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17GeneCards, 18GeneDecks
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Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Autoimmune Disease of the Nervous System
central nervous system disease Congenital Nervous System Abnormality

Diseases related to Central Nervous System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 482)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.9APOH, IL18, CD40LG
2systemic lupus erythematosus30.9CXCR3, IL18, APOH, CD40LG, CD46, CCR5
3leukemia30.7PLAUR, CXCR3, CD46, CD40LG, PROM1
4encephalomyelitis30.7MOG, CCR5, CXCR3
5multiple sclerosis30.5CCR5, MOG, CXCR3, IL18, GFAP, GC
6herpes simplex30.4GC
7meningitis30.4CD46
8hepatitis30.3CD40LG, IL18
9vasculitis30.3APOH, CD40LG, CD46
10encephalitis30.2TSPO, GFAP, CD46, MOG, CCR5
11alzheimer's disease30.2CXCR3, GFAP, CHRM2, TSPO, SLC1A3, PLAUR
12melanoma30.2CXCR3, CCR5, CD46, PLAUR
13myocardial infarction30.1PROM1, CCR5
14dementia30.1TSPO, CHRM1, CCR5, GFAP, SLC1A3
15arthritis30.1CXCR3, IL18, CCR5
16tuberculosis30.1PLAUR, CXCR3, GC, IL18
17adenocarcinoma30.1PLAUR, TSPO, CCR5, CD46
18viral infectious disease30.1CCR5, PLAUR, CHRM2, CXCR3, CD46, CD40LG
19ischemia29.9SLC1A3, CHRM2, GFAP
20schizophrenia29.9CHRM1, CHRM2, CHRM5, SLC1A3, TSPO, MOG
21prion disease29.9TSPO, SLC1A3, GFAP
22astrocytoma29.9CHRM1, CD46, TSPO, SLC1A3, GFAP, PLAUR
23optic neuritis29.8MOG
24rubella29.8CD40LG
25sjogren's syndrome29.8CXCR3, APOH, CD40LG, CHRM3
26sarcoidosis29.8CCR5, CXCR3, IL18
27hepatocellular carcinoma29.8CD46, PROM1, TSPO, PLAUR
28bipolar disorder29.6TSPO
29wernicke encephalopathy29.6TSPO
30uveitis29.6CXCR3, CCR5
31nephrotic syndrome29.6GC
32behcet's disease29.6APOH, IL18, CCR5
33thrombocytopenia29.6APOH, CD40LG, CD46
34cadasil29.5APOH, SLC1A3, TSPO, GC
35nervous system disease11.3
36central nervous system leukemia10.5
37acute leukemia10.5
38lymphocytic choriomeningitis10.5
39measles10.5
40brain disease10.5
41central nervous system lymphoma10.4
42histiocytosis10.4
43langerhans-cell histiocytosis10.4
44pneumonia10.4
45autoimmune disease of central nervous system10.4
46lymphoblastic leukemia10.4
47peripheral nervous system disease10.4
48stomatitis10.4
49siderosis10.3
50cerebritis10.3

Graphical network of the top 20 diseases related to Central Nervous System Disease:



Diseases related to central nervous system disease

Clinical Features for Central Nervous System Disease

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Drugs & Therapeutics for Central Nervous System Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Central Nervous System Disease

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Disease

Search NIH Clinical Center for Central Nervous System Disease

Search CenterWatch for Central Nervous System Disease

Genetic Tests for Central Nervous System Disease

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Anatomical Context for Central Nervous System Disease

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32MalaCards
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MalaCards organs/tissues related to Central Nervous System Disease:

32
Brain, Spinal cord, T cells, Testes, B cells, Myeloid, Bone marrow, Pituitary, Kidney, Bone, Liver, Monocytes, Retina, Skin

Animal Models for Central Nervous System Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Central Nervous System Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.5SLC1A3, GFAP, CHRM3, CHRM2, MOG
2MP:00053698.5CCR5, MOG, CHRM5, CHRM4, CHRM2, CHRM3
3MP:00053858.0CCR5, PROM1, CHRM5, CHRM4, CHRM2, CHRM3
4MP:00053868.0CHRM4, CHRM5, PROM1, MOG, CCR5, CHRM2
5MP:00036317.8CHRM4, CHRM5, PROM1, MOG, CCR5, CHRM2
6MP:00053767.7SLC1A3, GC, CCR5, APOH, CHRM5, CHRM4

Publications for Central Nervous System Disease

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50PubMed
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Articles related to Central Nervous System Disease:

(show top 50)    (show all 481)
idTitleAuthorsYear
1
The Central Nervous System Phenotype of X-Linked Charcot-Marie-Tooth Disease: A Transient Disorder of Children and Young Adults. (23400245)
2013
2
A novel missense mutation (N78D) in a family with von Hippel-Lindau disease with central nervous system haemangioblastomas, pancreatic and renal cysts. (23224817)
2013
3
Genetic variants in the host restriction factor APOBEC3G are associated with HIV-1-related disease progression and central nervous system impairment in children. (23138837)
2013
4
scAAV9 intracisternal delivery results in efficient gene transfer to the central nervous system of a feline model of motor neuron disease. (23799774)
2013
5
MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma. (22729947)
2012
6
Sustained response to intrathecal rituximab in EBV associated Post-transplant lymphoproliferative disease confined to the central nervous system following haematopoietic stem cell transplant. (21584931)
2012
7
Successful treatment with azathioprine of relapsing Rosai-Dorfman disease of the central nervous system. (22725985)
2012
8
Diagnosis and management of Rosai-Dorfman disease involving the central nervous system. (20350368)
2010
9
Methamphetamine and lentivirus interactions: reciprocal enhancement of central nervous system disease. (20608774)
2010
10
Identifying predictors of central nervous system disease in solid organ transplant recipients with cryptococcosis. (20061921)
2010
11
DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain. (19729484)
2009
12
Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease. (20033986)
2009
13
Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease. (19864606)
2009
14
Classical nodular sclerosis Hodgkin lymphoma presenting with central nervous system disease. (17534105)
2007
15
Chemokines and their receptors in central nervous system disease. (16454698)
2006
16
Sequence variation in the CC-chemokine ligand 2 promoter of pigtailed macaques is not associated with the incidence or severity of neuropathology in a simian immunodeficiency virus model of human immunodeficiency virus central nervous system disease. (17162657)
2006
17
Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system. (14972652)
2004
18
Whipple disease confined to the central nervous system presenting as a solitary frontal tumor. Case report. (15309928)
2004
19
Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course. (14530364)
2003
20
Association of Chlamydia pneumoniae with central nervous system disease. (14623021)
2003
21
CCL2 transgene expression in the central nervous system directs diffuse infiltration of CD45(high)CD11b(+) monocytes and enhanced Theiler's murine encephalomyelitis virus-induced demyelinating disease. (14602575)
2003
22
Functional expression of chemokine receptor CCR5 on CD4(+) T cells during virus-induced central nervous system disease. (12477824)
2003
23
Atypical inflammation in the central nervous system in prion disease. (12045736)
2002
24
Searching for clues: tracking the pathogenesis of human immunodeficiency virus central nervous system disease by use of an accelerated, consistent simian immunodeficiency virus macaque model. (12424698)
2002
25
CXCR3 expression in human central nervous system diseases. (11437993)
2001
26
Laboratory diagnosis of human cytomegalovirus (HCMV) central nervous system disease in AIDS patients. (11118856)
2000
27
Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and central nervous system function. (10942425)
2000
28
Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases. (10080385)
1999
29
CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease. (10583604)
1999
30
Impact of Kaposi's sarcoma in occurrence of opportunistic central nervous system disease. Clinical Epidemiology Group. (10513664)
1999
31
Analysis of tissues that reflect central nervous system disease by mass spectrometry. (10533851)
1999
32
Bone marrow transplantation as effective treatment of central nervous system disease in globoid cell leukodystrophy, metachromatic leukodystrophy, adrenoleukodystrophy, mannosidosis, fucosidosis, aspartylglucosaminuria, Hurler, Maroteaux-Lamy, and Sly syndromes, and Gaucher disease type III. (10226749)
1999
33
Central nervous system disease in Langerhans cell histiocytosis. (9561901)
1998
34
Mapping of a neurovirulence determinant within the envelope protein of a polytropic murine retrovirus: induction of central nervous system disease by low levels of virus. (9721229)
1998
35
Methotrexate in patients with moderate systemic lupus erythematosus (exclusion of renal and central nervous system disease). (9227169)
1997
36
Craniospinal irradiation for acute lymphoblastic leukemia with central nervous system disease at diagnosis: a report from the Children's Cancer Group. (8823255)
1996
37
Long-standing latent idiopathic hypoparathyroidism discovered during concurrent central nervous system disease. (1441480)
1992
38
Optic neuropathy and central nervous system disease associated with primary SjAPgren's syndrome. (1605151)
1992
39
Host genes conferring resistance to a central nervous system disease induced by a polytropic recombinant Friend murine retrovirus. (2153219)
1990
40
Beta-endorphin alters a viral induced central nervous system disease in normal mice but not in nude mice. (2553770)
1989
41
Immunohistochemical demonstration of GM2-ganglioside in the central nervous system of a 19-week-old fetus of Tay-Sachs disease. (2512447)
1989
42
Cytopathology of alpha chain disease involving the central nervous system and pleura. (2462320)
1988
43
Cyclic esotropia with central nervous system disease: report of two cases. (3681610)
1987
44
Pathogenesis of central nervous system disease caused by varicella virus. (3763429)
1986
45
Cerebrospinal fluid IgM, IgA, and IgG indexes in systemic lupus erythematosus. Their use as estimates of central nervous system disease activity. (3899036)
1985
46
von Hippel-Lindau disease: angiomatosis of the retina and central nervous system. (7322482)
1981
47
Resistance to fatal central nervous system disease by mouse hepatitis virus, strain JHM. II. Adherent cell-mediated protection. (6245128)
1980
48
Bromide partition test in the evaluation of the blood-cerebrospinal barrier in children with congenital hypothyroidism and central nervous system disease. (1224969)
1975
49
Primary progressive multifocal leukoencephalopathy. A central nervous system disease caused by a slow virus. (5055344)
1972
50
Circadian patterns of urinary electrolyte excretion in central nervous system disease. (6048036)
1967

Genetic Variations for Central Nervous System Disease

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Expression for genes affiliated with Central Nervous System Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Disease

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Pathways for genes affiliated with Central Nervous System Disease

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37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Central Nervous System Disease

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11DrugBank, 59Tocris Bioscience, 28IUPHAR, 44Novoseek, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Central Nervous System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 196)
idCompoundScoreTop Affiliating Genes
1Hyoscyamine119.9CHRM1, CHRM3, CHRM4, CHRM2
24-damp59 2810.9CHRM2, CHRM4, CHRM1, CHRM5, CHRM3
3vu0255035289.9CHRM1, CHRM3, CHRM2, CHRM4, CHRM5
4methylfurmethide289.9CHRM1, CHRM3, CHRM2, CHRM4
5ipratropium289.9CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
6nnc 11-1585289.9CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
7[3h]qnb289.9CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
8[3h]n-methyl scopolamine289.9CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
9nnc 11-1607289.9CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
10nnc 11-1314289.9CHRM2, CHRM4, CHRM5, CHRM1, CHRM3
11af-dx 11628 5910.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
12afdx384289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
13hhsid289.9CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
14p-f-hhsid289.9CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
15Homatropine Methylbromide119.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
16brucine n-oxide289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
17propantheline28 1110.9CHRM4, CHRM2, CHRM1, CHRM3
18n-chloromethyl-brucine289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
19Cryptenamine119.9CHRM3, CHRM1, CHRM5, CHRM4, CHRM2
20Metixene119.9CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
21Trihexyphenidyl119.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
22(-)aceclidine289.9CHRM1, CHRM3, CHRM2, CHRM4, CHRM5
23(+)aceclidine289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
24mt3289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
25n-benzyl brucine289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
26mt7289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
27win 62,577289.8CHRM3, CHRM1, CHRM2, CHRM4
28Solifenacin119.8CHRM2, CHRM1, CHRM3, CHRM4, CHRM5
29Aclidinium119.8CHRM2, CHRM3, CHRM5, CHRM4, CHRM1
30Benzquinamide119.8CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
31himbacine28 4410.8CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
32methoctramine44 2810.8CHRM1, CHRM2, CHRM4, CHRM5, CHRM3
33sabcomeline289.8CHRM3, CHRM1, CHRM4, CHRM5
34darifenacin44 28 1111.8CHRM3, CHRM4, CHRM2, CHRM1, CHRM5
35brucine2 28 4411.8CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
36Fesoterodine119.8CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
37tolterodine44 49 28 1112.8CHRM3, CHRM1, CHRM2, CHRM5, CHRM4
38thiochrome289.8CHRM4, CHRM2, CHRM1, CHRM3
39Chlorprothixene119.8CHRM5, CHRM4, CHRM1, CHRM2, CHRM3
40Propiomazine119.8CHRM5, CHRM2, CHRM1, CHRM4, CHRM3
41brompheniramine44 11 2411.8CHRM4, CHRM5, CHRM2, CHRM1, CHRM3
42promethazine44 1110.7CHRM1, CHRM5, CHRM4, CHRM2, CHRM3
43strychnine44 2 2811.7CHRM5, CHRM3, CHRM1, CHRM2, CHRM4
44maprotiline44 1110.7CHRM5, CHRM1, CHRM4, CHRM2, CHRM3
45xanomeline28 4410.7CHRM2, CHRM1, CHRM3, CHRM4, CHRM5
46gö 7874289.7CHRM4, CHRM2, CHRM1, CHRM3
47scopolamine44 28 11 2412.6CHRM5, TSPO, CHRM3, CHRM1, CHRM2, CHRM4
48milameline289.6CHRM3, CHRM1, CHRM4, CHRM5
49oxotremorine-m289.5CHRM3, CHRM1, CHRM2, CHRM4
50acetylcholine44 49 28 11 2412.8TSPO, CHRM5, CHRM1, CHRM3, CHRM4, CD40LG

GO Terms for genes affiliated with Central Nervous System Disease

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16Gene Ontology
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Cellular components related to Central Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1asymmetric synapseGO:03227910.2CHRM3, CHRM1
2postsynaptic membraneGO:0452119.4CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
3cell surfaceGO:0099869.2CCR5, APOH, PROM1, CD46, PLAUR, SLC1A3
4cell junctionGO:0300549.2CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
5integral to plasma membraneGO:0058878.4PLAUR, CCR5, PROM1, CHRM5, CHRM4, CHRM2
6plasma membraneGO:0058867.9CHRM4, CHRM5, PROM1, MOG, CCR5, CHRM2

Biological processes related to Central Nervous System Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayGO:00720710.3CHRM2, CHRM1
2saliva secretionGO:04654110.1CHRM3, CHRM1
3regulation of locomotionGO:04001210.1CHRM4, CHRM1
4adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayGO:00719710.0CHRM4, CHRM5
5G-protein coupled acetylcholine receptor signaling pathwayGO:0072139.9CHRM1, CHRM4, CHRM5
6G-protein coupled receptor signaling pathwayGO:0071869.8CHRM3, CHRM1, CHRM2, CCR5
7cell proliferationGO:0082839.5TSPO, CHRM3, CHRM1, CHRM4, CHRM5
8inflammatory responseGO:0069549.4CCR5, CD40LG, CXCR3, IL18

Molecular functions related to Central Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol phospholipase C activityGO:0044359.7CHRM3, CHRM1, CHRM5, CCR5
2G-protein coupled acetylcholine receptor activityGO:0169079.2CHRM3, CHRM1, CHRM2, CHRM4, CHRM5

Products for genes affiliated with Central Nervous System Disease

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Sources for Central Nervous System Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet