CNS
MCID: CNT035
MIFTS: 60

Central Nervous System Disease (CNS) malady

Neuronal diseases category

Summaries for Central Nervous System Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.

MalaCards: Central Nervous System Disease, also known as CNS, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Central Nervous System Disease is CHRM1 (cholinergic receptor, muscarinic 1), and among its related pathways are GPCRs, Other and Calcium signaling pathway. The compounds win 62,577 and methylfurmethide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related mouse phenotypes are vision/eye and muscle.

Wikipedia:63 The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal... more...

Aliases & Classifications for Central Nervous System Disease

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8Disease Ontology, 38NCBI Bookshelf, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Central Nervous System Disease

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17GeneCards, 18GeneDecks
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Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Autoimmune Disease of the Nervous System
central nervous system disease Congenital Nervous System Abnormality

Diseases related to Central Nervous System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 482)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.9APOH, IL18, CD40LG
2systemic lupus erythematosus30.9CXCR3, IL18, APOH, CD40LG, CD46, CCR5
3leukemia30.7PLAUR, CXCR3, CD46, CD40LG, PROM1
4encephalomyelitis30.7MOG, CCR5, CXCR3
5multiple sclerosis30.5CCR5, MOG, CXCR3, IL18, GFAP, GC
6herpes simplex30.4GC
7meningitis30.4CD46
8hepatitis30.3CD40LG, IL18
9vasculitis30.3APOH, CD40LG, CD46
10encephalitis30.2TSPO, GFAP, CD46, MOG, CCR5
11alzheimer's disease30.2CXCR3, GFAP, CHRM2, TSPO, SLC1A3, PLAUR
12melanoma30.2CXCR3, CCR5, CD46, PLAUR
13myocardial infarction30.1PROM1, CCR5
14dementia30.1TSPO, CHRM1, CCR5, GFAP, SLC1A3
15arthritis30.1CXCR3, IL18, CCR5
16tuberculosis30.1PLAUR, CXCR3, GC, IL18
17adenocarcinoma30.1PLAUR, TSPO, CCR5, CD46
18viral infectious disease30.1CCR5, PLAUR, CHRM2, CXCR3, CD46, CD40LG
19ischemia29.9SLC1A3, CHRM2, GFAP
20schizophrenia29.9CHRM1, CHRM2, CHRM5, SLC1A3, TSPO, MOG
21prion disease29.9TSPO, SLC1A3, GFAP
22astrocytoma29.9CHRM1, CD46, TSPO, SLC1A3, GFAP, PLAUR
23optic neuritis29.8MOG
24rubella29.8CD40LG
25sjogren's syndrome29.8CXCR3, APOH, CD40LG, CHRM3
26sarcoidosis29.8CCR5, CXCR3, IL18
27hepatocellular carcinoma29.8CD46, PROM1, TSPO, PLAUR
28bipolar disorder29.6TSPO
29wernicke encephalopathy29.6TSPO
30uveitis29.6CXCR3, CCR5
31nephrotic syndrome29.6GC
32behcet's disease29.6APOH, IL18, CCR5
33thrombocytopenia29.6APOH, CD40LG, CD46
34cadasil29.5APOH, SLC1A3, TSPO, GC
35nervous system disease11.3
36central nervous system leukemia10.5
37acute leukemia10.5
38lymphocytic choriomeningitis10.5
39measles10.5
40brain disease10.5
41central nervous system lymphoma10.4
42histiocytosis10.4
43langerhans-cell histiocytosis10.4
44pneumonia10.4
45autoimmune disease of central nervous system10.4
46lymphoblastic leukemia10.4
47peripheral nervous system disease10.4
48stomatitis10.4
49siderosis10.3
50cerebritis10.3

Graphical network of the top 20 diseases related to Central Nervous System Disease:



Diseases related to central nervous system disease

Clinical Features for Central Nervous System Disease

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Drugs & Therapeutics for Central Nervous System Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Central Nervous System Disease

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Disease

Search NIH Clinical Center for Central Nervous System Disease

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Genetic Tests for Central Nervous System Disease

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Anatomical Context for Central Nervous System Disease

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32MalaCards
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MalaCards organs/tissues related to Central Nervous System Disease:

32
Brain, Spinal cord, T cells, Testes, B cells, Myeloid, Pituitary, Bone marrow, Kidney, Bone, Monocytes, Liver, Skin, Retina

Animal Models for Central Nervous System Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Central Nervous System Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.5SLC1A3, GFAP, CHRM3, CHRM2, MOG
2MP:00053698.5CCR5, MOG, CHRM5, CHRM4, CHRM2, CHRM3
3MP:00053858.0CCR5, PROM1, CHRM5, CHRM4, CHRM2, CHRM3
4MP:00053868.0CHRM4, CHRM5, PROM1, MOG, CCR5, CHRM2
5MP:00036317.8CHRM4, CHRM5, PROM1, MOG, CCR5, CHRM2
6MP:00053767.7SLC1A3, GC, CCR5, APOH, CHRM5, CHRM4

Publications for Central Nervous System Disease

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Sources:
50PubMed
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Articles related to Central Nervous System Disease:

(show top 50)    (show all 481)
idTitleAuthorsYear
1
Lymphoproliferative disease of the central nervous system in a patient with dermatomyositis on immunomodulation therapy. (23211434)
2013
2
Childhood primary angiitis of the central nervous system: identifying disease trajectories and early risk factors for persistently higher disease activity. (22544528)
2012
3
Imaging characteristics of Rosai-Dorfman disease in the central nervous system. (21440399)
2012
4
Curative treatment for central nervous system medulloepithelioma despite residual disease after resection. Report of two cases treated according to the GPHO Protocol HIT 2000 and review of the literature. (22037651)
2011
5
Erdheim-Chester disease of the central nervous system: new manifestations of a rare disease. (21960492)
2011
6
Epilepsy and other central nervous system diseases in atypical autism: a case control study. (21207076)
2011
7
Marchiafava-Bignami disease-like lesions due to central nervous system lupus. (22798099)
2010
8
Significance of surface epithelial cells in canine cerebrospinal fluid and relationship to central nervous system disease. (20727124)
2010
9
CMV central nervous system disease in stem-cell transplant recipients: an increasing complication of drug-resistant CMV infection and protracted immunodeficiency. (20190836)
2010
10
Questioning the role of actinfree Gc-Globulin as actin scavenger in neurodegenerative central nervous system disease: relationship to S-100B levels and blood-brain barrier function. (19000909)
2009
11
Biomarkers of HIV related central nervous system disease. (18240064)
2008
12
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. (18156204)
2008
13
Statins--treatment option for central nervous system autoimmune disease? (17920550)
2007
14
Peripheral blood gene expression signature mirrors central nervous system disease: the model of multiple sclerosis. (17027885)
2006
15
Relapsing-remitting central nervous system disease in a young child. (17768787)
2005
16
Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease. (15974903)
2005
17
Widespread gene transduction to the central nervous system by adenovirus in utero: implication for prenatal gene therapy to brain involvement of lysosomal storage disease. (15459963)
2004
18
Cell-based therapy of chronic degenerative diseases of the central nervous system. (12903713)
2003
19
Emergence of late cytomegalovirus central nervous system disease in hematopoietic stem cell transplant recipients. (12393485)
2003
20
Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. (12915819)
2003
21
Cytomegalovirus glycoprotein B genotypes and central nervous system disease in AIDS patients. (12966546)
2003
22
Concurrent syrinx and inflammatory central nervous system disease detected by magnetic resonance imaging: an illustrative case and review of the literature. (11807404)
2002
23
Immune-mediated protection from measles virus-induced central nervous system disease is noncytolytic and gamma interferon dependent. (11932415)
2002
24
Central and peripheral nervous system dysfunction in the clinical variation of Salla disease. (10891913)
2000
25
Exposure to electromagnetic fields and risk of central nervous system disease in utility workers. (10955406)
2000
26
Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system. (10318940)
1999
27
Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group. (9681857)
1998
28
A close temporal relationship of liver disease to antiribosomal P0 protein antibodies and central nervous system disease in patients with systemic lupus erythematosus. (9558169)
1998
29
Microglia in cell culture and in transplantation therapy for central nervous system disease. (10071070)
1998
30
Erdheim-Chester disease of the central nervous system. Report of two cases. (9126908)
1997
31
Expression of tissue factor is increased in astrocytes within the central nervous system during persistent infection with borna disease virus. (8709198)
1996
32
Primary angiitis of the central nervous system associated with Hodgkin's disease. (8651860)
1996
33
Intrinsic responses to Borna disease virus infection of the central nervous system. (8917593)
1996
34
Association of antiphospholipid antibodies with central nervous system disease in systemic lupus erythematosus. (7573096)
1995
35
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. (7857654)
1995
36
Degenerative central nervous system disease. (8539193)
1995
37
Central nervous system disease in SjAPgren's syndrome. (7653943)
1995
38
Role of growth factors in degeneration and regeneration in the central nervous system; clinical experiences with NGF in Parkinson's and Alzheimer's diseases. (7699401)
1994
39
Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system. (7836946)
1994
40
The significance of in-situ Ia antigen expression in the pathogenesis of autoimmune central nervous system disease. (8397714)
1993
41
Electrocardiographic changes in central nervous system disease. (8316185)
1993
42
Miscellaneous vasculitic syndromes including BehAset's disease and central nervous system vasculitis. (8435289)
1993
43
Gastroesophageal reflux: a significant association with central nervous system disease in children. (2023076)
1991
44
Occult retinitis pigmentosa simulating central nervous system disease. (677670)
1978
45
Hodgkin's disease and granulomatous angiitis of the central nervous system. (186177)
1976
46
Electronystagmographic findings in central nervous system disease. (1079442)
1975
47
Measles and central nervous system disease. A critical appraisal. (4444685)
1974
48
Central nervous system disease in humans due to simultaneous epidemics of echovirus type 9 and western encephalomyelitis virus infection in Alberta. (5657183)
1968
49
Viral central nervous system disease. An etiologic study conducted at the Los Angeles County General Hospital. (14464000)
1962
50
Epidemic central nervous system disease of mixed enterovirus etiology. II. Analysis of laboratory investigations. (14407515)
1960

Genetic Variations for Central Nervous System Disease

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Expression for genes affiliated with Central Nervous System Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Disease

Search GEO for disease gene expression data for Central Nervous System Disease.

Pathways for genes affiliated with Central Nervous System Disease

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37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Central Nervous System Disease

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28IUPHAR, 59Tocris Bioscience, 11DrugBank, 44Novoseek, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Central Nervous System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 196)
idCompoundScoreTop Affiliating Genes
1win 62,5772810.0CHRM1, CHRM2, CHRM4, CHRM3
2methylfurmethide289.9CHRM1, CHRM2, CHRM4, CHRM3
3(+)aceclidine289.9CHRM2, CHRM1, CHRM3, CHRM4, CHRM5
4eburnamonine289.9CHRM2, CHRM3, CHRM1, CHRM4
5vu0255035289.9CHRM3, CHRM1, CHRM2, CHRM5, CHRM4
6af-dx 11628 5910.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
7afdx384289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
8mt3289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
9nnc 11-1314289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
10hhsid289.9CHRM2, CHRM1, CHRM3, CHRM4, CHRM5
11nnc 11-1607289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
12nnc 11-1585289.9CHRM5, CHRM4, CHRM3, CHRM1, CHRM2
13p-f-hhsid289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
14Metixene119.9CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
15Cryptenamine119.9CHRM1, CHRM3, CHRM2, CHRM4, CHRM5
16Homatropine Methylbromide119.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
17brucine n-oxide289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
18oxotremorine-m289.9CHRM1, CHRM4, CHRM2, CHRM3
19Trihexyphenidyl119.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
20mt7289.9CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
21(-)aceclidine289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
22n-benzyl brucine289.9CHRM3, CHRM5, CHRM4, CHRM2, CHRM1
23n-chloromethyl-brucine289.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
24[3h]n-methyl scopolamine289.9CHRM5, CHRM4, CHRM1, CHRM2, CHRM3
25[3h]qnb289.9CHRM5, CHRM4, CHRM2, CHRM3, CHRM1
264-damp59 2810.9CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
27ipratropium289.9CHRM3, CHRM5, CHRM4, CHRM2, CHRM1
28propantheline28 1110.8CHRM1, CHRM2, CHRM4, CHRM3
29Aclidinium119.8CHRM5, CHRM4, CHRM2, CHRM3, CHRM1
30Benzquinamide119.8CHRM5, CHRM2, CHRM4, CHRM1, CHRM3
31Solifenacin119.8CHRM2, CHRM1, CHRM4, CHRM5, CHRM3
32himbacine28 4410.8CHRM2, CHRM4, CHRM1, CHRM3, CHRM5
33brucine2 28 4411.8CHRM2, CHRM1, CHRM3, CHRM5, CHRM4
34darifenacin44 28 1111.8CHRM4, CHRM2, CHRM1, CHRM5, CHRM3
35methoctramine44 2810.8CHRM4, CHRM5, CHRM2, CHRM3, CHRM1
36Fesoterodine119.8CHRM4, CHRM5, CHRM2, CHRM1, CHRM3
37tolterodine44 49 28 1112.8CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
38Chlorprothixene119.8CHRM5, CHRM1, CHRM4, CHRM3, CHRM2
39gö 7874289.8CHRM4, CHRM2, CHRM1, CHRM3
40brompheniramine44 11 2411.8CHRM5, CHRM4, CHRM2, CHRM3, CHRM1
41Propiomazine119.8CHRM2, CHRM3, CHRM4, CHRM5, CHRM1
42promethazine44 1110.7CHRM3, CHRM5, CHRM4, CHRM2, CHRM1
43strychnine44 2 2811.7CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
44maprotiline44 1110.7CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
45xanomeline28 4410.7CHRM4, CHRM2, CHRM3, CHRM1, CHRM5
46scopolamine44 28 11 2412.6TSPO, CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
47silahexocyclium289.6CHRM3, CHRM4, CHRM5, CHRM2
48milameline289.5CHRM5, CHRM4, CHRM1, CHRM3
49hexocyclium289.3CHRM3, CHRM2, CHRM4, CHRM5
50acetylcholine44 49 28 11 2412.8CHRM2, CHRM1, CHRM3, CHRM5, IL18, GFAP

GO Terms for genes affiliated with Central Nervous System Disease

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16Gene Ontology
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Cellular components related to Central Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1asymmetric synapseGO:03227910.2CHRM3, CHRM1
2postsynaptic membraneGO:0452119.4CHRM4, CHRM5, CHRM2, CHRM1, CHRM3
3cell surfaceGO:0099869.2CCR5, APOH, PROM1, CD46, PLAUR, SLC1A3
4cell junctionGO:0300549.2CHRM1, CHRM5, CHRM4, CHRM2, CHRM3
5integral to plasma membraneGO:0058878.4CCR5, CXCR3, CD40LG, CD46, CHRM3, CHRM1
6plasma membraneGO:0058867.9CHRM3, CCR5, MOG, SLC1A3, PLAUR, CXCR3

Biological processes related to Central Nervous System Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayGO:00720710.3CHRM2, CHRM1
2saliva secretionGO:04654110.1CHRM3, CHRM1
3regulation of locomotionGO:04001210.1CHRM4, CHRM1
4adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayGO:00719710.0CHRM5, CHRM4
5G-protein coupled acetylcholine receptor signaling pathwayGO:0072139.9CHRM1, CHRM4, CHRM5
6G-protein coupled receptor signaling pathwayGO:0071869.8CCR5, CHRM2, CHRM1, CHRM3
7cell proliferationGO:0082839.5TSPO, CHRM3, CHRM1, CHRM4, CHRM5
8inflammatory responseGO:0069549.4CCR5, CD40LG, CXCR3, IL18

Molecular functions related to Central Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol phospholipase C activityGO:0044359.7CHRM3, CHRM1, CHRM5, CCR5
2G-protein coupled acetylcholine receptor activityGO:0169079.2CHRM3, CHRM1, CHRM2, CHRM4, CHRM5

Products for genes affiliated with Central Nervous System Disease

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Sources for Central Nervous System Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet