Central Nervous System Disease malady

Disease Ontology: A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.⁶

MalaCards: Central Nervous System Disease, also known as cns disorder, is related to immunodeficiency and systemic lupus erythematosus. An important gene associated with Central Nervous System Disease is CHRM5 (cholinergic receptor, muscarinic 5), and among its related pathways are Muscarinic acetylcholine receptors and NFAT Signaling and Lymphocyte Interactions. The compounds pge2 and Procyclidine have been mentioned in the context of this disorder. Affiliated tissues include brain, retina and spinal cord, and related mouse phenotypes are renal/urinary system and respiratory system.

Wikipedia: The central nervous system (CNS) is the part of the nervous system that integrates the information that...⁴⁴ more...

Aliases & Descriptions:

central nervous system disease 6 8 cns disorder 43

cns 26

Diseases related to central nervous system disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 601)

id	Related Disease	Score	Top Affiliating Genes
1	immunodeficiency	29.8	CHRM2, MOG, CD40LG, IL18, IL6, APOH
2	systemic lupus erythematosus	28.3	CD40LG, CD46, ITGAM, IL18, IL6, APOH
3	measles	27.7	CD40LG, CD46, IL1B, IL6, NFKB1
4	neurodegenerative disease	27.7	CHRM1, IL1B, PPARG, NOS2, GFAP, TSPO
5	gliosis	27.3	IL6, GFAP, TSPO, SLC1A3
6	amyotrophic lateral sclerosis	26.3	CCL2, PPARG, NOS2, GFAP, TSPO, CXCR3
7	lateral sclerosis	26.3	CCL2, PPARG, NOS2, GFAP, TSPO, CXCR3
8	neurodegeneration	26.1	MOG, IL18, IL1B, CCL2, CCR5, NOS2
9	optic neuritis	25.7	MOG, CD40LG, APOH, CCR5, GFAP
10	neuromyelitis optica	25.6	MOG, IL6, GFAP
11	tuberous sclerosis	25.5	GC, CCL2, NFKB1, GFAP, TSPO
12	tuberculosis	25.4	IL1B, CCL2, NOS2
13	sleep disorder	25.3	MOG, IL6, TSPO
14	anoxia	25.2	PPARG, NOS2, GFAP, TSPO
15	choroiditis	25.0	CHRM2, IL1B, CCL2, PPARG, NOS2, GFAP
16	nervous system disease	25.0	GC, CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
17	subacute sclerosing panencephalitis	25.0	MOG, CD46, IL1B, IL6
18	aids dementia complex	24.9	IL1B, CCR5, PLAUR, NOS2
19	neuritis	24.8	MOG, CD40LG, IL1B, APOH, CCR5, GFAP
20	mumps	24.8	CD40LG, CD46, IL1B, IL6
21	acute leukemia	24.5	CD40LG, CD46, ITGAM, IL1B, IL6, PLAUR
22	lupus erythematosus	24.5	MOG, CD40LG, CD46, ITGAM, IL18, IL1B
23	meningitis	24.4	MOG, CD40LG, CD46, IL1B, IL6, APOH
24	encephalomyelitis	24.4	MOG, CD40LG, IL18, IL1B, IL6, CCL2
25	mood disorder	24.2	IL1B, IL6, CCL2, GFAP, TSPO
26	acute lymphoblastic leukemia	23.9	CD40LG, ITGAM, IL18, IL1B, IL6, APOH
27	brain injury	23.8	CHRM1, IL18, IL1B, IL6, CCL2, NOS2
28	rubella	23.8	MOG, CD40LG, IL1B, IL6, CCR5, NFKB1
29	alcohol dependence	23.7	CHRM2, IL1B, IL6, PPARG, NFKB1
30	headache	23.5	CD40LG, IL1B, IL6, APOH, CCL2, NOS2
31	lymphoblastic leukemia	23.5	CD40LG, ITGAM, IL18, IL1B, IL6, APOH
32	kaposi's sarcoma	23.3	IL1B, IL6, CCL2, NOS2, NFKB1, CXCR3
33	t-cell leukemia	23.2	CD40LG, IL1B, IL6, CCL2, CCR5, NFKB1
34	anemia	23.1	CD40LG, CD46, IL18, IL1B, IL6, APOH
35	aldosteronism	22.8	IL1B, IL6, CCL2, PPARG, PLAUR, NOS2
36	nephrotic syndrome	22.7	GC, CD40LG, IL18, IL1B, IL6, APOH
37	multiple sclerosis	22.7	GC, CHRM2, CHRM3, MOG, CD40LG, CD46
38	seizures	22.6	CD40LG, IL18, IL1B, IL6, NOS2, GFAP
39	homocysteine	22.5	CD40LG, IL18, IL6, APOH, CCL2, PPARG
40	lung adenocarcinoma	22.5	IL6, CCL2, CCR5, PPARG, PLAUR, NOS2
41	leukemia	22.4	GC, CHRM3, CD40LG, CD46, ITGAM, IL18
42	neurologic diseases	22.2	MOG, IL18, IL1B, IL6, APOH, NOS2
43	alzheimer's disease	22.0	CHRM2, CHRM1, CD40LG, ITGAM, IL18, IL1B
44	myelodysplastic syndrome	21.9	CD40LG, IL1B, IL6, PPARG, PLAUR, NOS2
45	neuroblastoma	21.4	CHRM2, CHRM1, CHRM3, CHRM4, IL18, IL1B
46	lung carcinoma	21.4	CHRM3, CD46, IL1B, IL6, CCL2, PPARG
47	dementia	21.0	CHRM2, CHRM1, CHRM4, IL1B, IL6, APOH
48	parkinson's disease	21.0	CHRM3, CD40LG, IL1B, IL6, CCL2, CCR5
49	herpes simplex	21.0	GC, CD40LG, IL18, IL1B, IL6, CCL2
50	sarcoidosis	20.8	ITGAM, IL18, IL1B, IL6, APOH, CCL2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to central nervous system disease:

²²

MGI Mouse Phenotypes related to central nervous system disease:

²⁵ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.0	CHRM2, CHRM3
2	respiratory system phenotype	MP:0005388	9.7	CHRM3, CHRM1, CHRM2
3	liver/biliary system phenotype	MP:0005370	9.1	CCR5, IL6, CHRM4, CHRM3, CHRM2
4	nervous system phenotype	MP:0003631	8.9	SLC1A3, PROM1, PLAUR, ITGAM, MOG, CHRM1
5	immune system phenotype	MP:0005387	8.5	GFAP, PLAUR, IL6, ITGAM, MOG
6	digestive/alimentary phenotype	MP:0005381	8.2	GFAP, NOS2, CCR5, CCL2, IL18, CHRM3
7	adipose tissue phenotype	MP:0005375	7.9	CHRM3, IL18, IL6, CCL2, PPARG, NOS2
8	growth/size phenotype	MP:0005378	7.3	PROM1, GFAP, NFKB1, PLAUR, IL6, IL18
9	tumorigenesis	MP:0002006	7.3	CXCR3, PROM1, NOS2, PPARG, CCR5, CCL2
10	vision/eye phenotype	MP:0005391	6.7	SLC1A3, PROM1, GFAP, NOS2, PPARG, CCR5
11	muscle phenotype	MP:0005369	6.3	CCR5, PPARG, PLAUR, NOS2, NFKB1, GFAP
12	cardiovascular system phenotype	MP:0005385	5.7	PPARG, PLAUR, NOS2, GFAP, PROM1, CXCR3
13	behavior/neurological phenotype	MP:0005386	5.7	PPARG, PLAUR, NOS2, NFKB1, GFAP, PROM1
14	homeostasis/metabolism phenotype	MP:0005376	5.3	GC, CCR5, PPARG, PLAUR, NOS2, NFKB1
15	cellular phenotype	MP:0005384	5.3	SLC1A3, CXCR3, PROM1, GFAP, NFKB1, NOS2

Articles related to central nervous system disease:

(show all 15)

id	Title	Authors	Year	Affiliating Genes
1	High prevalence of autoantibodies against phosphoglyc erate mutase 1 in patients with autoimmune central nervous system diseases. (19969379)	Kimura A.... Inuzuka T.	2010	PGAM1
2	Antibodies to native myelin oligodendrocyte glycoprot ein in children with inflammatory demyelinating central nervous system disease. (20033986)	Brilot F.... Hemmer B.	2009	MOG
3	Questioning the role of actinfree Gc-Globulin as actin scavenger in neurodegenerative central nervous system disease: relationship to S-100B levels and blood-brain barrier function. (19000909)	Gressner O.A.... Gressner A.M.	2009	GC
4	The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease. (18096722)	Huttner H.B.... Corbeil D.	2008	PROM1
5	Sequence variation in the CC-chemokine ligand 2 promoter of pigtailed macaques is not associated with the incidence or severity of neuropathology in a simian immunodeficiency virus model of human immunodeficiency virus central nervous system disease. (17162657)	Wright E.K.... Barber S.A.	2006	CCL2
6	PPARgamma as a therapeutic target in central nervous system diseases. (16766086)	Sundararajan S.... Landreth G.	2006	PPARG
7	Expression of the urokinase plasminogen activator and its receptor in HIV-1-associated central nervous system disease. (15579290)	Sidenius N.... Cinque P.	2004	PLAUR
8	Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease. (15765809)	Von Giesen H.J.... Arendt G.	2004	IL18
9	Functional expression of chemokine receptor CCR5 on CD4(+) T cells during virus-induced central nervous system disease. (12477824)	Glass W.G.... Lane T.E.	2003	CCR5
10	A novel simian immunodeficiency virus model that provides insight into mechanisms of human immunodeficiency virus central nervous system disease. (12491150)	Zink M.C.... Clements J.E.	2002	CCL2
11	CXCR3 expression in human central nervous system diseases. (11437993)	Goldberg S.H.... Lavi E.	2001	CXCR3
12	The clinical relevance of antibodies to ribosomal-P common epitope in two targeted systemic lupus erythematosus populations: a large cohort of consecutive patients and patients with active central nervous system disease. (10666163)	Tzioufas A.G.... Moutsopoulos H.M.	2000	APOH
13	Immune response-mediated protection of adult but not neonatal mice from neuron-restricted measles virus infection and central nervous system disease. (9971756)	Lawrence D.M.... Rall G.F.	1999	CD46
14	A close temporal relationship of liver disease to antiribosomal P0 protein antibodies and central nervous system disease in patients with systemic lupus erythematosus. (9558169)	Yoshio T.... Kano S.	1998	CD40LG
15	The M22 antibody identifies highly activated reactive astrocytes responding to central nervous system disease. (8834543)	Eddleston M.... Oldstone M.B.	1996	IL6, GFAP

Genes related to central nervous system disease according to GeneCards:

(show all 27)

id	Symbol	Description	Score	GeneCards Section Context
1	CHRM5	cholinergic receptor, muscarinic 5	11.1	Summaries
2	CHRM4	cholinergic receptor, muscarinic 4	11.1	Summaries
3	CHRM1	cholinergic receptor, muscarinic 1	11.1	Summaries
4	CHRM2	cholinergic receptor, muscarinic 2	11.1	Summaries
5	CHRM3	cholinergic receptor, muscarinic 3	11.1	Summaries
6	PGAM1	phosphoglycerate mutase 1 (brain)	11.0	Publications
7	MOG	myelin oligodendrocyte glycoprotein	11.0	Publications
8	GC	group-specific component (vitamin D binding protein)	11.0	Publications
9	POLR1D	polymerase (RNA) I polypeptide D, 16kDa	11.0
10	PROM1	prominin 1	11.0	Publications
11	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	11.0
12	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
13	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
14	TSPO	translocator protein (18kDa)	11.0
15	PLAUR	plasminogen activator, urokinase receptor	11.0	Publications
16	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
17	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
18	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
19	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
20	CD40LG	CD40 ligand	11.0	Publications
21	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	11.0
22	GFAP	glial fibrillary acidic protein	11.0	Publications
23	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
24	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0
25	IL1B	interleukin 1, beta	11.0
26	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
27	NOS2	nitric oxide synthase 2, inducible	11.0

Pathways related to central nervous system disease according to GeneDecks:

(show top 50)    (show all 54)

id	Pathway	Score	Top Affiliating Genes
1	Muscarinic acetylcholine receptors38	10.5	CHRM1, CHRM5
2	NFAT Signaling and Lymphocyte Interactions36	10.4	CCL2
3	Amine ligand-binding receptors38	10.2	CHRM2, CHRM3, CHRM4
4	Regulation of actin cytoskeleton20	10.1	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
5	Cholinergic synapse20	10.1	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
6	Neuroactive ligand-receptor interaction20	9.8	TSPO, CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
7	Calcium signaling pathway20	9.7	NOS2, CHRM3, CHRM1, CHRM5, CHRM2
8	PGC1Alpha Pathway36	9.5	IL1B, IL18
9	Molecular Mechanisms of Cancer36	9.5	ITGAM, IL6
10	Development_VEGF signaling via VEGFR2 - generic cascades41	9.3	NFKB1, NOS2, PLAUR, CCL2
11	Toxoplasmosis20	9.0	CD40LG, CCR5, NOS2, NFKB1
12	Immune response_MIF-mediated glucocorticoid regulation41	9.0	NFKB1, NOS2, IL6
13	Inflammasome Activation Pathways37	9.0	IL18, IL1B, NFKB1
14	Immune response MIF-mediated glucocorticoid regulation10	9.0	NFKB1, NOS2, IL6
15	Regulation of eIF4 and p70S6K36	9.0	IL6, IL18, ITGAM
16	MSP-RON Signaling36	9.0	CCL2, IL1B, IL18, ITGAM
17	IL-10 Pathway36	8.9	IL1B, IL6, NFKB1
18	Immune response IL-12-induced IFN-gamma production10	8.8	NFKB1, NOS2, IL18
19	Cytokine Network36	8.8	IL6, IL1B, IL18
20	Leishmaniasis20	8.8	NFKB1, NOS2, IL1B, ITGAM
21	African trypanosomiasis20	8.7	IL18, IL1B, IL6
22	Toll-Like Receptor Signaling Pathways37	8.6	NFKB1, IL6, IL1B, IL18
23	Rheumatoid arthritis20	8.6	IL18, IL1B, IL6, CCL2
24	Immune response_MIF in innate immunity response41	8.6	NFKB1, NOS2, IL6, IL1B
25	Immune response MIF in innate immunity response10	8.6	NFKB1, NOS2, IL6, IL1B
26	Immune response_Bacterial infections in normal airways41	8.5	NFKB1, NOS2, IL6, IL1B
27	Immune response IL-1 signaling pathway10	8.5	NFKB1, NOS2, IL6, IL1B
28	Immune response_IL-1 signaling pathway41	8.5	IL1B, IL6, NOS2, NFKB1
29	Cytosolic DNA-sensing pathway20	8.5	POLR1D, NFKB1, IL6, IL1B, IL18
30	Measles20	8.4	NFKB1, IL6, IL1B, CD46
31	Malaria20	8.4	CD40LG, IL18, IL1B, IL6, CCL2
32	NOD-like receptor signaling pathway20	8.3	NFKB1, CCL2, IL6, IL1B, IL18
33	MIF Mediated Glucocorticoid Regulation36	8.3	NFKB1, CCL2, IL6, IL1B, IL18
34	MIF Regulation of Innate Immune Cells36	8.3	NFKB1, CCL2, IL6, IL1B, IL18
35	PEDF Induced Signaling36	8.3	NFKB1, CCL2, IL6, IL1B, IL18
36	Chagas disease (American trypanosomiasis)20	8.3	IL1B, IL6, CCL2, NOS2, NFKB1
37	Akt Signaling36	8.3	CXCR3, CCR5, CCL2, IL6, IL18, ITGAM
38	Influenza A20	8.2	NFKB1, CCL2, IL6, IL1B, IL18
39	IL-6 Pathway36	8.2	IL18, IL1B, IL6, CCL2, NFKB1
40	STAT3 Pathway36	8.2	CXCR3, CCR5, CCL2, IL6, IL1B, IL18
41	Glucocorticoid Receptor Signaling36	8.2	IL18, IL1B, IL6, CCL2, NFKB1
42	all-trans-Retinoic Acid Signaling in Brain36	8.2	IL18, IL1B, IL6, CCL2
43	Pertussis20	8.1	NFKB1, NOS2, IL6, IL1B, ITGAM
44	Amoebiasis20	8.0	NFKB1, NOS2, IL6, IL1B, ITGAM
45	Cytokine-cytokine receptor interaction20	7.9	CXCR3, CCR5, CCL2, IL6, IL1B, IL18
46	Antioxidant Action of Vitamin-C36	7.8	CXCR3, NFKB1, CCR5, CCL2, IL6, IL1B
47	p38 Signaling36	7.8	CXCR3, NFKB1, CCR5, CCL2, IL6, IL1B
48	Tuberculosis20	7.6	NFKB1, NOS2, IL6, IL1B, IL18, ITGAM
49	Tec Kinases Signaling36	7.3	CXCR3, NFKB1, CCR5, CCL2, IL6, IL1B
50	Rho Family GTPases36	7.3	GFAP, NFKB1, CCL2, IL6, IL1B, IL18

Compounds related to central nervous system disease according to GeneDecks:

(show top 50)    (show all 202)

id	Compound	Score	Top Affiliating Genes
1	pge232	10.4	PPARG, PLAUR
2	Procyclidine9 9	11.2	CHRM2, CHRM1, CHRM3, CHRM4
3	tropicamide32 42 9 9	13.2	CHRM4, CHRM3, CHRM1, CHRM2
4	glucose32	10.2	SLC1A3
5	Hyoscyamine9 9	11.2	CHRM4, CHRM3, CHRM2, CHRM1
6	Trihexyphenidyl9 9	11.1	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
7	Metixene9 9	11.1	CHRM2, CHRM5, CHRM1, CHRM4, CHRM3
8	Cryptenamine9 9	11.1	CHRM3, CHRM1, CHRM5, CHRM2, CHRM4
9	Homatropine Methylbromide9 9	11.1	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
10	Solifenacin9 9	11.1	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
11	Benzquinamide9 9	11.1	CHRM4, CHRM5, CHRM3, CHRM2, CHRM1
12	darifenacin32 9 9	12.1	CHRM4, CHRM1, CHRM5, CHRM2, CHRM3
13	Fesoterodine9 9	11.1	CHRM3, CHRM5, CHRM2, CHRM1, CHRM4
14	tolterodine32 34 9 9	13.1	CHRM3, CHRM2, CHRM5, CHRM1, CHRM4
15	Chlorprothixene9 9	11.1	CHRM4, CHRM3, CHRM2, CHRM5, CHRM1
16	Propiomazine9 9	11.1	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
17	brompheniramine32 9 18 9	13.1	CHRM1, CHRM2, CHRM5, CHRM3, CHRM4
18	promethazine32 9 9	12.1	CHRM3, CHRM5, CHRM1, CHRM4, CHRM2
19	maprotiline32 9 9	12.0	CHRM1, CHRM5, CHRM2, CHRM3, CHRM4
20	promazine32 9 9	12.0	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
21	Methotrimeprazine9 9	11.0	CHRM1, CHRM4, CHRM3, CHRM5, CHRM2
22	doxepin32 34 9 9	12.9	CHRM2, CHRM5, CHRM4, CHRM3, CHRM1
23	scopolamine32 9 18 9	12.9	CHRM2, CHRM5, TSPO, CHRM1, CHRM3, CHRM4
24	nortriptyline32 34 9 9	12.9	CHRM3, CHRM4, CHRM1, CHRM5, CHRM2
25	paroxetine32 34 9 9	12.7	CHRM3, CHRM1, CHRM5, CHRM2, CHRM4
26	n acetylcysteine32	9.6	PLAUR, IL18, ITGAM
27	aripiprazole32 34 9 18 9	13.4	CHRM4, CHRM1, CHRM2, CHRM5, CHRM3
28	endotoxin32	9.0	ITGAM, CXCR3, PLAUR, APOH, IL18, GC
29	cocaine32 9 9	10.7	CD40LG, CHRM1, TSPO, CHRM2, GFAP, APOH
30	calcium32 9 18 9	11.6	CXCR3, CHRM2, CHRM5, CHRM1, MOG, CD46
31	groalpha32	8.2	IL6, IL1B, IL18, CCL2, CCR5, CXCR3
32	il-1232	8.2	CD40LG, IL18, IL6, CCL2, IL1B
33	acetylcholine32 9 18 9	11.1	TSPO, CHRM3, CHRM2, CHRM1, MOG, CD40LG
34	il 1032	8.1	CXCR3, IL18, IL1B, IL6, CCL2, CCR5
35	estrogen32	8.0	GFAP, TSPO, NOS2, PLAUR, PPARG, APOH
36	ccl332	8.0	CXCR3, CCL2, CCR5, IL6, IL1B, IL18
37	vegf32	7.8	GFAP, PPARG, CCL2, APOH, IL1B, PLAUR
38	adenylate32	7.6	NOS2, CHRM2, GC, CHRM1, CHRM3, CD40LG
39	superoxide32 18	8.2	GFAP, NOS2, SLC1A3, CCL2, APOH, ITGAM
40	rantes32	7.1	IL18, CD40LG, IL6, CCL2, CCR5, CXCR3
41	arginine32	7.0	CHRM1, PLAUR, CD40LG, IL18, CCR5, CCL2
42	histamine32 18	7.9	CXCR3, CCR5, CCL2, IL6, IL1B, IL18
43	creatinine32	6.8	GFAP, CCL2, PLAUR, IL18, APOH, IL6
44	indomethacin32 9 9	8.8	IL1B, TSPO, NOS2, ITGAM, CD40LG, PLAUR
45	cholesterol32 9 18 9	9.7	IL6, APOH, CCR5, CXCR3, IL18, PPARG
46	genistein32 9 18 9	9.6	IL6, GFAP, IL1B, NOS2, PLAUR, CCL2
47	lipid32	6.3	IL6, ITGAM, CHRM1, PPARG, CCL2, APOH
48	cycloheximide32	6.2	CCL2, GFAP, NOS2, PLAUR, PPARG, CD46
49	dexamethasone32 42 34 9 9	9.6	IL1B, CD40LG, CXCR3, PPARG, PLAUR, CD46
50	nitric oxide32 9 18 9	8.6	IL18, CXCR3, ITGAM, CD46, MOG, CHRM2

Cellular components related to central nervous system disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	asymmetric synapse	GO:032279	10.0	CHRM2, CHRM1, CHRM3, CHRM4
2	axon terminus	GO:043679	10.0	CHRM4, CHRM3, CHRM1, CHRM2
3	postsynaptic membrane	GO:045211	9.7	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
4	cell junction	GO:030054	9.7	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
5	cell surface	GO:009986	9.1	SLC1A3, PROM1, PLAUR, CCR5, APOH, CD46
6	integral to plasma membrane	GO:005887	8.3	CXCR3, PROM1, PLAUR, CCR5, CD46, CD40LG
7	extracellular space	GO:005615	7.1	PROM1, CCL2, APOH, IL6, IL1B, IL18
8	plasma membrane	GO:005886	7.0	ITGAM, CCR5, PLAUR, PROM1, CXCR3, SLC1A3

Biological processes related to central nervous system disease according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	GO:007197	10.5	CHRM5, CHRM4
2	G-protein coupled acetylcholine receptor signaling pathway	GO:007213	10.3	CHRM5, CHRM1, CHRM4
3	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	GO:007207	10.3	CHRM1, CHRM2
4	chemokine-mediated signaling pathway	GO:070098	9.9	CCL2, CCR5, CXCR3
5	chemotaxis	GO:006935	9.6	CXCR3, PLAUR, CCR5, CCL2
6	organ regeneration	GO:031100	9.6	APOH, CCL2, PPARG
7	response to bacterium	GO:009617	9.6	NFKB1, NOS2, CCL2
8	regulation of vascular endothelial growth factor production	GO:010574	9.6	CCL2, IL6
9	G-protein coupled receptor signaling pathway	GO:007186	9.5	CHRM2, CHRM1, CHRM3, CCL2, CCR5
10	cell proliferation	GO:008283	9.5	TSPO, CHRM4, CHRM3, CHRM1, CHRM5
11	cellular response to interferon-gamma	GO:071346	9.5	NOS2, CCL2, IL18
12	positive regulation of granulocyte macrophage colony-stimulating factor production	GO:032725	9.5	IL1B, IL18
13	cellular response to lipopolysaccharide	GO:071222	9.5	TSPO, NOS2, CCR5, CCL2
14	lipopolysaccharide-mediated signaling pathway	GO:031663	9.3	CCL2, IL1B, IL18
15	positive regulation of interferon-gamma production	GO:032729	9.3	CD40LG, IL18, IL1B
16	cellular response to organic cyclic compound	GO:071407	9.1	PPARG, CCL2, IL1B, IL18
17	MAPK cascade	GO:000165	9.1	IL18, IL1B, CCL2, CCR5
18	cellular response to mechanical stimulus	GO:071260	8.7	NFKB1, IL1B, IL18
19	response to hypoxia	GO:001666	8.6	IL18, IL1B, CCL2, NOS2
20	inflammatory response	GO:006954	7.6	CD40LG, IL18, IL1B, IL6, CCL2, CCR5

Molecular functions related to central nervous system disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	G-protein coupled acetylcholine receptor activity	GO:016907	9.7	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
2	phosphatidylinositol phospholipase C activity	GO:004435	9.6	CCR5, CHRM3, CHRM1, CHRM5
3	drug binding	GO:008144	9.4	PPARG, CHRM3, CHRM1, CHRM2
4	cytokine activity	GO:005125	8.2	CD40LG, IL18, IL1B, IL6