CNS
MCID: CNT035
MIFTS: 52

Central Nervous System Disease (CNS) malady

Neuronal category

Summaries for Central Nervous System Disease

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.

MalaCards: Central Nervous System Disease, also known as CNS, is related to systemic lupus erythematosus and vasculitis. An important gene associated with Central Nervous System Disease is CHRM1 (cholinergic receptor, muscarinic 1), and among its related pathways are GPCRs, Other and Calcium signaling pathway. The compounds alcuronium and (+)aceclidine have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and muscle.

Wikipedia:64 The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal... more...

Aliases & Classifications for Central Nervous System Disease

Sources:
8Disease Ontology, 39NCBI Bookshelf, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Related Diseases for Central Nervous System Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the nervous system disease family:

autoimmune disease of central nervous system autoimmune disease of the nervous system
central nervous system disease congenital nervous system abnormality

Diseases related to Central Nervous System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 480)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus31.0CXCR3, IL18, APOH, CD40LG, CD46, CCR5
2vasculitis30.4APOH, CD40LG, CD46
3hepatitis c30.4CCR5, CD40LG, CXCR3, IL18
4arthritis30.2CXCR3, IL18, CCR5
5sjogren's syndrome30.2CXCR3, APOH, CD40LG, CHRM3
6tuberculosis30.2PLAUR, CXCR3, GC, IL18
7adenocarcinoma30.2PLAUR, TSPO, CCR5, CD46
8viral infectious disease30.2CCR5, PLAUR, CHRM2, CXCR3, CD46, CD40LG
9alzheimer's disease30.1CXCR3, GFAP, CHRM2, TSPO, SLC1A3, PLAUR
10astrocytoma29.9CHRM1, CD46, TSPO, SLC1A3, GFAP, PLAUR
11blindness29.8TSPO
12rubella29.8CD40LG
13bipolar disorder29.6TSPO
14wernicke encephalopathy29.6TSPO
15uveitis29.6CXCR3, CCR5
16anaplastic astrocytoma29.6PLAUR, GFAP
17thrombocytopenia29.6APOH, CD40LG, CD46
18cadasil29.6APOH, SLC1A3, TSPO, GC
19n syndrome10.8
20central nervous system leukemia10.6
21acute leukemia10.6
22brain disease10.6
23lymphocytic choriomeningitis10.5
24measles10.5
25central nervous system lymphoma10.5
26stomatitis10.4
27germinoma10.4
28acute myeloid leukemia10.4
29kaposi's sarcoma10.4
30siderosis10.4
31superficial siderosis10.3
32lymphomatoid granulomatosis10.3
33subacute sclerosing panencephalitis10.3
34acquired immunodeficiency syndrome10.3
35hepatitis d10.3
36mumps10.3
37urinary system disease10.3
38hepatitis c virus10.3
39lip disease10.3
40hematopoietic stem cell transplantation10.3
41germ cell tumors10.2
42granulomatous angiitis10.2
43wallerian degeneration10.2
44atypical teratoid rhabdoid tumor10.2
45whipple disease10.2
46fucosidosis10.1
47atypical autism10.1
48central nervous system tuberculosis10.1
49gaucher's disease10.1
50hodgkin's lymphoma, nodular sclerosis10.1

Graphical network of the top 20 diseases related to Central Nervous System Disease:



Diseases related to central nervous system disease

Clinical Features for Central Nervous System Disease

Drugs & Therapeutics for Central Nervous System Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Central Nervous System Disease

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Disease

Search NIH Clinical Center for Central Nervous System Disease

Search CenterWatch for Central Nervous System Disease

Genetic Tests for Central Nervous System Disease

Anatomical Context for Central Nervous System Disease

Animal Models for Central Nervous System Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Central Nervous System Disease

Sources:
51PubMed
See all sources

Articles related to Central Nervous System Disease:

(show top 50)    (show all 482)
idTitleAuthorsYear
1
Imaging in classic form of maple syrup urine disease: a rare metabolic central nervous system. (24049754)
2013
2
Post-transplant lymphoproliferative disorder: the significance of central nervous system disease. (22717024)
2012
3
Possible central nervous system vasculitis as an early presentation of Crohn's disease. A challenge in diagnosis and management. (22964818)
2012
4
Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker. (22918699)
2012
5
Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. (21387369)
2011
6
Erlotinib therapy for central nervous system hemangioblastomatosis associated with von Hippel-Lindau disease: a case report. (20524042)
2011
7
Mycoplasma pneumoniae: Innocent Bystander or a True Cause of Central Nervous System Disease? (21308543)
2010
8
Detection of myelin autoantibodies: evaluation of an assay system for diagnosis of multiple sclerosis in differentiation from other central nervous system diseases. (19912047)
2009
9
Concurrent renal cell carcinoma and central nervous system lymphoma in a patient with autosomal dominant polycystic kidney disease. (19797927)
2009
10
Encapsulated living choroid plexus cells: potential long-term treatments for central nervous system disease and trauma. (19850973)
2009
11
Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system. (19657390)
2009
12
Early immune activation predicts central nervous system disease in HIV-infected infants: implications for early treatment. (19115973)
2009
13
Central nervous system vasculitis after starting methimazole in a woman with Graves' disease. (18788922)
2008
14
Gender hormones: role in the pathogenesis of central nervous system disease and demyelination. (18991657)
2008
15
The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease. (18096722)
2008
16
Progressive oxidative damage in the central nervous system of a murine model for juvenile Batten disease. (17638298)
2007
17
Central nervous system disease complicating Mycoplasma pneumoniae. (17875042)
2007
18
Statins in the treatment of central nervous system autoimmune disease. (16860400)
2006
19
Intraocular methotrexate in ocular diseases other than primary central nervous system lymphoma. (17056381)
2006
20
Proton magnetic resonance spectroscopy and diffusion-weighted imaging of central nervous system whipple disease. (15891498)
2005
21
Cerebellar ataxia and central nervous system whipple disease. (15824262)
2005
22
Update on neuroimaging in infectious central nervous system disease. (15247545)
2004
23
Combined antiretroviral therapy and the incidence of acquired immunodeficiency syndrome-related central nervous system diseases. (15293287)
2004
24
Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease. (15765809)
2004
25
Lentiviral vectors for gene transfer to the central nervous system. Applications in lysosomal storage disease animal models. (12526176)
2003
26
Bcl-2 antisense oligonucleotides are effective against systemic but not central nervous system disease in severe combined immunodeficient mice bearing human t(14;18) follicular lymphoma. (11948143)
2002
27
Rosai-Dorfman disease isolated to the central nervous system: a report of 11 cases. (11266522)
2001
28
Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease. (10894213)
2000
29
Radiation therapy for benign central nervous system disease. (10092704)
1999
30
The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients. (10229773)
1999
31
Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus. (9817440)
1998
32
For which patients with aggressive non-Hodgkin's lymphoma is prophylaxis for central nervous system disease mandatory? Dutch HOVON Group. (9553665)
1998
33
HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP): a chronic progressive neurologic disease associated with immunologically mediated damage to the central nervous system. (9111175)
1997
34
Apoptosis in acute and chronic central nervous system disease induced by Theiler's murine encephalomyelitis virus. (9123847)
1997
35
Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: applications to HIV-induced central nervous system disease. (8900532)
1996
36
The concept of microglia in relation to central nervous system disease and regeneration. (8804116)
1996
37
Immunoreactivity of the central nervous system in cats with a Borna disease-like meningoencephalomyelitis (staggering disease). (7484095)
1995
38
Central nervous system disease in a child with primary SjAPgren syndrome. (8523198)
1995
39
Gestational trophoblastic disease metastatic to the central nervous system. (7590478)
1995
40
Central nervous system disease in acute lymphoblastic leukemia. (8443045)
1993
41
Central nervous system disease associated with Langerhans' cell histiocytosis. (8498649)
1993
42
Expression of HIV-1 in the cerebrospinal fluid detected by the polymerase chain reaction and its correlation with central nervous system disease. (1892587)
1991
43
Central nervous system disease: a dental diagnosis? (3268641)
1988
44
Nuclear magnetic resonance imaging in central nervous system disease. (6648538)
1983
45
Neuroblastoma presenting as central nervous system disease. (6816038)
1982
46
Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease. (6265583)
1981
47
Thrombocytosis, central nervous system disease, and myocardial infarction pattern in infancy. (5922179)
1966
48
WILSON'S DISEASE, AN INBORN ERROR OF METABOLISM AND A MODEL OF DEGENERATIVE CENTRAL NERVOUS SYSTEM DISEASE. (14156393)
1964
49
VIRAL CENTRAL NERVOUS SYSTEM DISEASE. (14043891)
1963
50
A comparative study of monkey kidney cell cultures and suckling mice for the recovery of enteroviruses from patients with central nervous system disease. (14464008)
1961

Genetic Variations for Central Nervous System Disease

Expression for genes affiliated with Central Nervous System Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Central Nervous System Disease

Search GEO for disease gene expression data for Central Nervous System Disease.

Pathways for genes affiliated with Central Nervous System Disease

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome
See all sources

Compounds for genes affiliated with Central Nervous System Disease

Sources:
29IUPHAR, 60Tocris Bioscience, 11DrugBank, 45Novoseek, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Central Nervous System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 196)
idCompoundScoreTop Affiliating Genes
1alcuronium2910.0CHRM3, CHRM1, CHRM4, CHRM2
2(+)aceclidine299.9CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
3vu0255035299.9CHRM1, CHRM3, CHRM2, CHRM4, CHRM5
4arecaidine propargyl ester299.9CHRM2, CHRM3, CHRM1, CHRM4
5af-dx 11629 6010.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
6afdx384299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
7mt3299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
8hhsid299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
9nnc 11-1607299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
10p-f-hhsid299.9CHRM3, CHRM1, CHRM5, CHRM4, CHRM2
11nnc 11-1314299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
12Metixene119.9CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
13Cryptenamine119.9CHRM1, CHRM3, CHRM2, CHRM4, CHRM5
14Homatropine Methylbromide119.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
15brucine n-oxide299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
16Trihexyphenidyl119.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
17pentylthio-tztp299.9CHRM1, CHRM2, CHRM4, CHRM3
18mt7299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
19(-)aceclidine299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
20n-benzyl brucine299.9CHRM3, CHRM1, CHRM5, CHRM4, CHRM2
21n-chloromethyl-brucine299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
22ipratropium299.9CHRM2, CHRM1, CHRM3, CHRM4, CHRM5
23[3h]n-methyl scopolamine299.9CHRM5, CHRM4, CHRM1, CHRM2, CHRM3
24[3h]qnb299.9CHRM5, CHRM2, CHRM1, CHRM3, CHRM4
254-damp60 2910.9CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
26nnc 11-1585299.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
27Benzquinamide119.8CHRM3, CHRM5, CHRM4, CHRM2, CHRM1
28Aclidinium119.8CHRM5, CHRM4, CHRM3, CHRM1, CHRM2
29Solifenacin119.8CHRM5, CHRM2, CHRM1, CHRM4, CHRM3
30himbacine29 4510.8CHRM4, CHRM5, CHRM2, CHRM1, CHRM3
31brucine2 29 4511.8CHRM5, CHRM2, CHRM3, CHRM1, CHRM4
32methoctramine45 2910.8CHRM4, CHRM5, CHRM3, CHRM2, CHRM1
33darifenacin45 29 1111.8CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
34Fesoterodine119.8CHRM5, CHRM2, CHRM1, CHRM3, CHRM4
35silahexocyclium299.8CHRM3, CHRM2, CHRM4, CHRM5
36tolterodine45 50 29 1112.8CHRM5, CHRM4, CHRM1, CHRM3, CHRM2
37Chlorprothixene119.8CHRM3, CHRM4, CHRM5, CHRM2, CHRM1
38furmethide299.8CHRM4, CHRM2, CHRM1, CHRM3
39vincamine299.8CHRM3, CHRM1, CHRM2, CHRM4
40brompheniramine45 11 2411.8CHRM4, CHRM5, CHRM2, CHRM1, CHRM3
41Propiomazine119.8CHRM3, CHRM4, CHRM5, CHRM1, CHRM2
42promethazine45 1110.7CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
43strychnine45 2 2911.7CHRM5, CHRM1, CHRM3, CHRM2, CHRM4
44maprotiline45 1110.7CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
45xanomeline29 4510.7CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
46hexocyclium299.7CHRM5, CHRM4, CHRM2, CHRM3
47scopolamine45 29 11 2412.6TSPO, CHRM5, CHRM1, CHRM4, CHRM3, CHRM2
48lithocholylcholine299.5CHRM2, CHRM3, CHRM4, CHRM5
49Procyclidine119.5CHRM1, CHRM4, CHRM2, CHRM3
50acetylcholine45 50 29 11 2412.8CHRM4, IL18, CHRM5, CHRM2, MOG, CD40LG

GO Terms for genes affiliated with Central Nervous System Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Central Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1asymmetric synapseGO:03227910.2CHRM3, CHRM1
2postsynaptic membraneGO:0452119.4CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
3cell surfaceGO:0099869.2CCR5, APOH, PROM1, CD46, PLAUR, SLC1A3
4cell junctionGO:0300549.2CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
5integral to plasma membraneGO:0058878.4PLAUR, CCR5, PROM1, CHRM5, CHRM4, CHRM2
6plasma membraneGO:0058867.9CHRM4, CHRM5, PROM1, MOG, CCR5, CHRM2

Biological processes related to Central Nervous System Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayGO:00720710.3CHRM2, CHRM1
2saliva secretionGO:04654110.1CHRM3, CHRM1
3regulation of locomotionGO:04001210.1CHRM4, CHRM1
4adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayGO:00719710.0CHRM4, CHRM5
5G-protein coupled acetylcholine receptor signaling pathwayGO:0072139.9CHRM1, CHRM4, CHRM5
6G-protein coupled receptor signaling pathwayGO:0071869.8CHRM3, CHRM1, CHRM2, CCR5
7cell proliferationGO:0082839.5TSPO, CHRM3, CHRM1, CHRM4, CHRM5
8inflammatory responseGO:0069549.4CCR5, CD40LG, CXCR3, IL18

Molecular functions related to Central Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol phospholipase C activityGO:0044359.7CHRM3, CHRM1, CHRM5, CCR5
2G-protein coupled acetylcholine receptor activityGO:0169079.2CHRM3, CHRM1, CHRM2, CHRM4, CHRM5

Products for genes affiliated with Central Nervous System Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Nervous System Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet