MCID: CNT037
MIFTS: 28

Central Nervous System Germinoma malady

Neuronal diseases, Endocrine diseases, Cancer diseases, Rare diseases categories
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Summaries for Central Nervous System Germinoma

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33MalaCards
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MalaCards: Central Nervous System Germinoma, also known as intracranial germinoma, is related to germinoma and seminoma. An important gene associated with Central Nervous System Germinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways is Selected targets of Oct 3 4. The compounds thyroxine and lactate have been mentioned in the context of this disorder.

Aliases & Classifications for Central Nervous System Germinoma

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8Disease Ontology, 49Orphanet, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

49
intracranial germinoma:
Inheritance: Sporadic; Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

central nervous system germinoma 8 62
intracranial germinoma 49 62
germinoma of the central nervous system 49
germinoma of cns 8


External Ids:

Disease Ontology8 DOID:4438
NCIt40 C7009

Related Diseases for Central Nervous System Germinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Central Nervous System Germinoma:



Diseases related to central nervous system germinoma

Symptoms for Central Nervous System Germinoma

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Drugs & Therapeutics for Central Nervous System Germinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Central Nervous System Germinoma

Search NIH Clinical Center for Central Nervous System Germinoma

Genetic Tests for Central Nervous System Germinoma

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Anatomical Context for Central Nervous System Germinoma

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Animal Models for Central Nervous System Germinoma or affiliated genes

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Publications for Central Nervous System Germinoma

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52PubMed
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Articles related to Central Nervous System Germinoma:

(show all 14)
idTitleAuthorsYear
1
Feasibility of dasatinib in children and adolescents with new or recurrent central nervous system germinoma. (23754592)
2013
2
An unusual case of primary central nervous system germinoma with meningeal dissemination. (22936081)
2012
3
Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation. (21495164)
2011
4
Outcome of central nervous system germinoma treatment by chemoradiation. (21516012)
2011
5
Regression of primary central nervous system germinoma after dexamethasone administration: a case report. (20367268)
2010
6
Long-term follow-up of dose-adapted and reduced-field radiotherapy with or without chemotherapy for central nervous system germinoma. (20045266)
2010
7
Diffusion-weighted imaging characteristics of primary central nervous system germinoma with histopathologic correlation: a retrospective study. (19643635)
2009
8
Management of central nervous system germinoma: proposal for a modern strategy. (19329866)
2009
9
Outcome of patients with recurrent medulloblastoma or central nervous system germinoma treated with low dose continuous intravenous etoposide along with dose-intensive chemotherapy followed by autologous hematopoietic stem cell rescue. (19326417)
2009
10
OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. (15725806)
2005
11
Patterns of failure after induction chemotherapy followed by consolidative radiation therapy for children with central nervous system germinoma. (14595717)
2003
12
Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma. (9420074)
1998
13
Radiation therapy for histologically confirmed primary central nervous system germinoma. (9276355)
1997
14
Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: report of 10 patients. (6256407)
1981

Variations for Central Nervous System Germinoma

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Expression for genes affiliated with Central Nervous System Germinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Germinoma

Search GEO for disease gene expression data for Central Nervous System Germinoma.

Pathways for genes affiliated with Central Nervous System Germinoma

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50PathCards, 12EMD Millipore
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Pathways related to Central Nervous System Germinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0CGB, POU5F1

Compounds for genes affiliated with Central Nervous System Germinoma

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45Novoseek, 24HMDB, 61Tocris Bioscience, 11DrugBank, 51PharmGKB
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Compounds related to Central Nervous System Germinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1thyroxine45 2410.4CGB, ALPP
2lactate459.3ALPP, CGB
3testosterone45 61 24 1112.3CGB, ALPP
4cisplatin45 51 61 1112.2CGB, ALPP
5norepinephrine45 24 1111.2ALPP, POU5F1
6creatinine459.0CGB, ALPP
7vegf458.7CGB, ALPP, POU5F1

GO Terms for genes affiliated with Central Nervous System Germinoma

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Products for genes affiliated with Central Nervous System Germinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Nervous System Germinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet