MCID: CNT037
MIFTS: 29

Central Nervous System Germinoma malady

Neuronal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Central Nervous System Germinoma

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32MalaCards
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MalaCards: Central Nervous System Germinoma, also known as intracranial germinoma, is related to seminoma and choriocarcinoma. An important gene associated with Central Nervous System Germinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways is Selected targets of Oct-3/4. The compounds norepinephrine and thyroxine have been mentioned in the context of this disorder. Affiliated tissues include brain and pineal.

Aliases & Classifications for Central Nervous System Germinoma

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Sources:
48Orphanet, 60UMLS, 8Disease Ontology, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
intracranial germinoma:
Inheritance: Sporadic; Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

central nervous system germinoma 8 60
intracranial germinoma 48 60
germinoma of the central nervous system 48
germinoma of cns 8


External Ids:

Disease Ontology8 DOID:4438
NCIt39 C7009

Related Diseases for Central Nervous System Germinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Central Nervous System Germinoma:



Diseases related to central nervous system germinoma

Clinical Features for Central Nervous System Germinoma

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Drugs & Therapeutics for Central Nervous System Germinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Nervous System Germinoma

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Germinoma

Search NIH Clinical Center for Central Nervous System Germinoma

Search CenterWatch for Central Nervous System Germinoma

Genetic Tests for Central Nervous System Germinoma

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Anatomical Context for Central Nervous System Germinoma

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32MalaCards
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MalaCards organs/tissues related to Central Nervous System Germinoma:

32
Brain, Pineal

Animal Models for Central Nervous System Germinoma or affiliated genes

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Publications for Central Nervous System Germinoma

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50PubMed
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Articles related to Central Nervous System Germinoma:

(show all 21)
idTitleAuthorsYear
1
Clinical use of (11)C-methionine and (18)F-FDG-PET for germinoma in central nervous system. (24272066)
2013
2
Feasibility of dasatinib in children and adolescents with new or recurrent central nervous system germinoma. (23754592)
2013
3
An unusual case of primary central nervous system germinoma with meningeal dissemination. (22936081)
2012
4
Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation. (21495164)
2011
5
Outcome of central nervous system germinoma treatment by chemoradiation. (21516012)
2011
6
Regression of primary central nervous system germinoma after dexamethasone administration: a case report. (20367268)
2010
7
Long-term follow-up of dose-adapted and reduced-field radiotherapy with or without chemotherapy for central nervous system germinoma. (20045266)
2010
8
Diffusion-weighted imaging characteristics of primary central nervous system germinoma with histopathologic correlation: a retrospective study. (19643635)
2009
9
Management of central nervous system germinoma: proposal for a modern strategy. (19329866)
2009
10
Outcome of patients with recurrent medulloblastoma or central nervous system germinoma treated with low dose continuous intravenous etoposide along with dose-intensive chemotherapy followed by autologous hematopoietic stem cell rescue. (19326417)
2009
11
The management of patients with primary central nervous system (CNS) germinoma: current controversies requiring resolution. (18421722)
2008
12
Genetic alterations of E-cadherin and beta-catenin in germinoma and teratoma: report of two central nervous system cases. (18158575)
2007
13
Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. (16718353)
2006
14
OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. (15725806)
2005
15
Patterns of failure after induction chemotherapy followed by consolidative radiation therapy for children with central nervous system germinoma. (14595717)
2003
16
Combined 201Tl and 67Ga brain SPECT in patients with suspected central nervous system lymphoma or germinoma: clinical and economic value. (12971633)
2003
17
Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma. (9420074)
1998
18
Radiation therapy for histologically confirmed primary central nervous system germinoma. (9276355)
1997
19
A phase II trial of preirradiation carboplatin in newly diagnosed germinoma of the central nervous system. (8039122)
1994
20
Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: report of 10 patients. (6256407)
1981
21
Metastases outside the central nervous system from a presumed pineal germinoma. Case report. (7420182)
1980

Genetic Variations for Central Nervous System Germinoma

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Expression for genes affiliated with Central Nervous System Germinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Germinoma

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Pathways for genes affiliated with Central Nervous System Germinoma

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12EMD Millipore
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Pathways related to Central Nervous System Germinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0POU5F1, CGB

Compounds for genes affiliated with Central Nervous System Germinoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Central Nervous System Germinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2411.1ALPP, POU5F1
2thyroxine44 2410.0ALPP, CGB
3vegf448.4ALPP, POU5F1, CGB

GO Terms for genes affiliated with Central Nervous System Germinoma

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Products for genes affiliated with Central Nervous System Germinoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Central Nervous System Germinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet