MCID: CNT037
MIFTS: 36

Central Nervous System Germinoma

Categories: Rare diseases, Neuronal diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Central Nervous System Germinoma

MalaCards integrated aliases for Central Nervous System Germinoma:

Name: Central Nervous System Germinoma 12 49 14 69
Intracranial Germinoma 49 55 69
Germinoma of the Central Nervous System 49 55
Germinoma of Cns 12

Characteristics:

Orphanet epidemiological data:

55
germinoma of the central nervous system
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood;

Classifications:



External Ids:

Disease Ontology 12 DOID:4438
NCIt 46 C7009
Orphanet 55 ORPHA91352
UMLS via Orphanet 70 C1333813

Summaries for Central Nervous System Germinoma

MalaCards based summary : Central Nervous System Germinoma, also known as intracranial germinoma, is related to brain germinoma and seminoma. An important gene associated with Central Nervous System Germinoma is JMJD1C (Jumonji Domain Containing 1C), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and G alpha (s) signalling events. The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells.

Related Diseases for Central Nervous System Germinoma

Diseases in the Central Nervous System Germinoma family:

Adult Central Nervous System Germinoma

Diseases related to Central Nervous System Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 brain germinoma 31.6 AVP POU5F1
2 seminoma 29.8 ALPP POU5F1
3 diabetes insipidus 29.4 AVP POMC
4 pituitary hormone deficiency, combined, 2 29.4 AVP POMC
5 diabetes insipidus, neurohypophyseal 29.3 AVP POMC
6 childhood central nervous system germinoma 12.3
7 adult central nervous system germinoma 12.3
8 malignant leydig cell tumor 10.1 POMC POU5F1
9 mediastinitis 10.0
10 multiple sclerosis 9.9
11 embryonal carcinoma 9.9
12 peritonitis 9.9
13 lennox-gastaut syndrome 9.9 ALPP POMC
14 medulloblastoma 9.9
15 fourth cranial nerve palsy 9.9
16 meningitis 9.9
17 tuberculous epididymitis 9.8 AVP POMC
18 inappropriate adh syndrome 9.8 AVP POMC
19 secondary hypertrophic osteoarthropathy 9.8 AVP POMC
20 central nervous system organ benign neoplasm 9.8 AVP POMC
21 syndrome of inappropriate antidiuretic hormone 9.8 AVP POMC
22 cervix small cell carcinoma 9.8 AVP POMC
23 premenstrual tension 9.8 AVP POMC
24 chromophobe adenoma 9.8 AVP POMC
25 epidermoid cysts 9.7
26 smith-lemli-opitz syndrome 9.7
27 opitz gbbb syndrome, type i 9.7
28 hypogonadotropic hypogonadism 9.7
29 cauda equina syndrome 9.7
30 cornelia de lange syndrome 9.7
31 teratoma 9.7
32 cerebritis 9.7
33 choriocarcinoma 9.7
34 polyradiculopathy 9.7
35 embryonal testis carcinoma 9.7
36 neuronitis 9.7
37 hypopituitarism 9.7
38 lymphocytic hypophysitis 9.7
39 testicular seminoma 9.7
40 tremor 9.7
41 growing teratoma syndrome 9.7
42 pancreas disease 9.7 AVP POMC
43 pituitary gland disease 9.7 AVP POMC
44 urinary system disease 9.5 AVP POMC
45 central nervous system germ cell tumor 9.5 AVP POMC POU5F1
46 small cell cancer of the lung 9.4 AVP POMC

Graphical network of the top 20 diseases related to Central Nervous System Germinoma:



Diseases related to Central Nervous System Germinoma

Symptoms & Phenotypes for Central Nervous System Germinoma

Drugs & Therapeutics for Central Nervous System Germinoma

Drugs for Central Nervous System Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
2
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
4
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
7
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
8
Ondansetron Approved Phase 3 99614-02-5 4595
9 Adjuvants, Immunologic Phase 3,Phase 1
10 Alkylating Agents Phase 3,Phase 2,Phase 1
11 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
12 Antirheumatic Agents Phase 3,Phase 2,Phase 1
13 Etoposide phosphate Phase 3,Phase 2,Phase 1
14 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
15 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
16 Antiemetics Phase 3,Phase 1
17 Autonomic Agents Phase 3,Phase 1
18 BB 1101 Phase 3,Phase 1
19 Dexamethasone acetate Phase 3,Phase 1 1177-87-3
20 Emetics Phase 3
21 Gastrointestinal Agents Phase 3,Phase 1
22 Peripheral Nervous System Agents Phase 3,Phase 1
23
Ifosfamide Approved Phase 2,Phase 1 3778-73-2 3690
24
Mechlorethamine Approved, Investigational Phase 2,Phase 1 51-75-2 4033
25 Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
26
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
27
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
28 Isophosphamide mustard Phase 2,Phase 1 0
29 Anti-Bacterial Agents Phase 2,Phase 1
30 Antibiotics, Antitubercular Phase 2
31 Liver Extracts Phase 1, Phase 2
32 Protein Kinase Inhibitors Phase 1, Phase 2
33
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166
34
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
35
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
36
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
37
Fluorouracil Approved Phase 1 51-21-8 3385
38
Levoleucovorin Approved, Investigational Phase 1 68538-85-2
39
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 43805 6857599 5310940 9887054
40
Sunitinib Approved, Investigational Phase 1 341031-54-7, 557795-19-4 5329102
41
Vincristine Approved, Investigational Phase 1 2068-78-2, 57-22-7 5978
42
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
43
Mannitol Approved, Investigational Phase 1 69-65-8 6251 453
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
45
leucovorin Approved, Nutraceutical Phase 1 58-05-9 143 6006
46
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1 68-26-8, 11103-57-4 445354
47 Histone Deacetylase Inhibitors Phase 1
48 Antidotes Phase 1
49 Antimetabolites Phase 1
50 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
2 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
3 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
4 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
5 Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma Recruiting NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin
6 Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Recruiting NCT01602666 Phase 2 carboplatin;etoposide;ifosfamide
7 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
8 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
9 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
10 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
11 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
12 Sunitinib in Treating Young Patients With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
13 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
14 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
15 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
16 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
17 Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Terminated NCT00238173 Phase 1 acetylcysteine;carboplatin;cyclophosphamide;etoposide phosphate;mannitol;sodium thiosulfate
18 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755
19 Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors Withdrawn NCT00897858

Search NIH Clinical Center for Central Nervous System Germinoma

Genetic Tests for Central Nervous System Germinoma

Anatomical Context for Central Nervous System Germinoma

MalaCards organs/tissues related to Central Nervous System Germinoma:

38
Brain, Spinal Cord, T Cells, Liver, Bone

Publications for Central Nervous System Germinoma

Articles related to Central Nervous System Germinoma:

(show all 16)
# Title Authors Year
1
Outcomes of children with central nervous system germinoma treated with multi-agent chemotherapy followed by reduced radiation. ( 26744133 )
2016
2
Improvement of Long-term Results with Neoadjuvant Chemotherapy andA Radiotherapy for Central Nervous System Germinoma. ( 26115804 )
2015
3
Feasibility of dasatinib in children and adolescents with new or recurrent central nervous system germinoma. ( 23754592 )
2013
4
An unusual case of primary central nervous system germinoma with meningeal dissemination. ( 22936081 )
2012
5
Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation. ( 21495164 )
2011
6
Outcome of central nervous system germinoma treatment by chemoradiation. ( 21516012 )
2011
7
Regression of primary central nervous system germinoma after dexamethasone administration: a case report. ( 20367268 )
2010
8
Long-term follow-up of dose-adapted and reduced-field radiotherapy with or without chemotherapy for central nervous system germinoma. ( 20045266 )
2010
9
Outcome of patients with recurrent medulloblastoma or central nervous system germinoma treated with low dose continuous intravenous etoposide along with dose-intensive chemotherapy followed by autologous hematopoietic stem cell rescue. ( 19326417 )
2009
10
Management of central nervous system germinoma: proposal for a modern strategy. ( 19329866 )
2009
11
Diffusion-weighted imaging characteristics of primary central nervous system germinoma with histopathologic correlation: a retrospective study. ( 19643635 )
2009
12
OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. ( 15725806 )
2005
13
Patterns of failure after induction chemotherapy followed by consolidative radiation therapy for children with central nervous system germinoma. ( 14595717 )
2003
14
Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma. ( 9420074 )
1998
15
Radiation therapy for histologically confirmed primary central nervous system germinoma. ( 9276355 )
1997
16
Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: report of 10 patients. ( 6256407 )
1981

Variations for Central Nervous System Germinoma

Expression for Central Nervous System Germinoma

Search GEO for disease gene expression data for Central Nervous System Germinoma.

Pathways for Central Nervous System Germinoma

Pathways related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.37 AVP POU5F1
2 11.12 AVP POMC
3 10.75 ALPP POU5F1

GO Terms for Central Nervous System Germinoma

Biological processes related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 generation of precursor metabolites and energy GO:0006091 8.62 AVP POMC

Molecular functions related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.16 AVP POMC
2 transcription regulatory region sequence-specific DNA binding GO:0000976 8.96 JMJD1C POU5F1
3 neuropeptide hormone activity GO:0005184 8.62 AVP POMC

Sources for Central Nervous System Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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