Central Nervous System Germinoma malady

MalaCards: Central Nervous System Germinoma, also known as germinoma of cns, is related to germinoma and germ cell tumor. An important gene associated with Central Nervous System Germinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways is Selected targets of Oct-3/4. The compounds norepinephrine and thyroxine have been mentioned in the context of this disorder.

Aliases & Descriptions:

central nervous system germinoma 6 8 43 germinoma of cns 6

germinoma 43

Diseases related to central nervous system germinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 59)

id	Related Disease	Score	Top Affiliating Genes
1	germinoma	30.8	CGB, ALPP, POU5F1
2	germ cell tumor	27.8	CGB, ALPP, POU5F1
3	teratoma	27.1	CGB, ALPP, POU5F1
4	seminoma	25.7	CGB, ALPP, POU5F1
5	mature teratoma	12.7	CGB, ALPP
6	placental site trophoblastic tumor	12.7	CGB, ALPP
7	endodermal sinus tumor	12.7	ALPP, CGB
8	lymphoepithelioma-like carcinoma	12.7	CGB, ALPP
9	gestational trophoblastic neoplasm	12.7	CGB, ALPP
10	sertoli cell tumor	12.7	CGB, ALPP
11	leydig cell tumor	12.7	CGB, ALPP
12	adrenal hyperplasia	12.7	CGB, ALPP
13	mediastinitis	12.6	CGB, ALPP
14	carcinoid tumors	12.6	CGB, ALPP
15	testicular cancer	12.6	CGB, ALPP
16	hyperthyroidism	12.5	CGB, ALPP
17	thalassemia	12.5	ALPP, CGB
18	down syndrome	12.4	POU5F1, CGB
19	teratocarcinoma	12.4	ALPP, POU5F1
20	endometrial adenocarcinoma	12.2	POU5F1, ALPP
21	bladder carcinoma	12.2	CGB, ALPP
22	pediatric cns embryonal cell carcinoma	12.1	ALPP, POU5F1
23	rectal cloacogenic carcinoma	12.0	CGB, ALPP
24	gonadoblastoma	11.9	POU5F1, ALPP, CGB
25	dysgerminoma	11.9	CGB, ALPP, POU5F1
26	turner syndrome	11.9	POU5F1, ALPP, CGB
27	testicular germ cell tumor	11.9	POU5F1, ALPP, CGB
28	pituitary adenoma	11.9	POU5F1, ALPP, CGB
29	osteosarcoma	11.8	POU5F1, ALPP, CGB
30	cervical cancer	11.8	CGB, ALPP, POU5F1
31	systemic lupus erythematosus	11.8	POU5F1, ALPP, CGB
32	adenoma	11.8	CGB, ALPP, POU5F1
33	lupus erythematosus	11.8	POU5F1, ALPP, CGB
34	sarcoma	11.7	POU5F1, ALPP, CGB
35	cervicitis	11.7	CGB, ALPP, POU5F1
36	squamous cell carcinoma	11.6	CGB, ALPP, POU5F1
37	ovarian cancer	11.5	POU5F1, ALPP, CGB
38	adult central nervous system germinoma	9.1
39	childhood central nervous system germinoma	9.1
40	brain germinoma	7.9
41	childhood brain germinoma	7.3
42	pineal region germinoma	7.0
43	diabetes insipidus	6.1
44	precocious puberty	6.1
45	cerebritis	6.1
46	carcinoma	6.1
47	virilization	5.2
48	21-hydroxylase deficiency	5.2
49	adenomatous polyposis coli	5.2
50	cholesterol	5.2

Approved drugs:

Drug clinical trials:

Articles related to central nervous system germinoma:

id	Title	Authors	Year	Affiliating Genes
1	Management of central nervous system germinoma: proposal for a modern strategy. (19329866)	Shibamoto Y.	2009	CGB
2	OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. (15725806)	Hattab E.M.... Cheng L.	2005	ALPP, POU5F1

Genes related to central nervous system germinoma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
2	POU5F1	POU class 5 homeobox 1	11.0	Publications
3	ALPP	alkaline phosphatase, placental	11.0	Publications

Pathways related to central nervous system germinoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of Oct-3/410	9.0	CGB, POU5F1

Compounds related to central nervous system germinoma according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	norepinephrine32 9 18 9	12.1	ALPP, POU5F1
2	thyroxine32 18	10.0	CGB, ALPP
3	vegf32	8.4	CGB, ALPP, POU5F1