MCID: CNT018
MIFTS: 35

Central Nervous System Leukemia malady

Neuronal diseases category

Summaries for Central Nervous System Leukemia

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Disease Ontology:9 A hematologic cancer located in the central nervous system.

MalaCards based summary: Central Nervous System Leukemia, also known as leukemia of the cns, is related to leukemia and intervertebral disc disease. An important gene associated with Central Nervous System Leukemia is IL1B (interleukin 1, beta), and among its related pathways are TRAF Pathway and Immune response IL 23 signaling pathway. The compounds tenidap and n,n-dimethylsphingosine have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system, bone and brain.

Aliases & Classifications for Central Nervous System Leukemia

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Central Nervous System Leukemia, Aliases & Descriptions:

Name: Central Nervous System Leukemia 9 11 60
 
Leukemia of the Cns 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:12969
NCIt38 C5440

Related Diseases for Central Nervous System Leukemia

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Diseases related to Central Nervous System Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.2TNF, ASRGL1, IL1B
2intervertebral disc disease10.3IL1B
3malaria10.3TNF
4skin disease10.3IL1B
5acute leukemia10.2
6severe combined immunodeficiency10.2
7diabetes insipidus10.2
8lymphoblastic leukemia10.2
9myeloid leukemia10.2
10acute myelomonocytic leukemia10.2
11blau syndrome10.1TNF, IL1B
12aids dementia complex10.1TNF, IL1B
13familial mediterranean fever, ar10.1TNF, IL1B
14chorioamnionitis10.1TNF, IL1B
15interstitial lung disease10.0IL1B, TNF
16psoriatic arthritis10.0TNF, IL1B
17toxic shock syndrome10.0TNF, IL1B
18acute respiratory distress syndrome10.0IL1B, TNF
19respiratory failure10.0TNF, IL1B
20peritonitis10.0TNF, IL1B
21periodontitis10.0IL1B, TNF
22arthropathy10.0IL1B, TNF
23synovitis10.0IL1B, TNF
24monocytic leukemia10.0IL1B, TNF
25periodontal disease10.0IL1B, TNF
26hypersensitivity reaction type ii disease10.0TNF, IL1B
27liver disease10.0TNF, IL1B
28sarcoidosis 110.0TNF, IL1B
29colitis10.0IL1B, TNF
30kidney disease10.0TNF, IL1B
31congenital heart disease10.0IL1B, TNF
32cork-handlers' disease10.0IL1B, TNF
33pneumonia10.0TNF, IL1B
34pancreatitis10.0IL1B, ASRGL1
35vascular disease10.0TNF, IL1B
36ulcerative colitis9.9TNF, IL1B
37inflammatory bowel disease9.9IL1B, TNF
38tuberculosis9.9TNF, IL1B
39osteoarthritis9.9IL1B, TNF
40arthritis9.9IL1B, TNF
41psoriasis9.8IL1B, TNF
42multiple sclerosis, disease progression, modifier of9.7IL1B, TNF

Graphical network of the top 20 diseases related to Central Nervous System Leukemia:



Diseases related to central nervous system leukemia

Symptoms for Central Nervous System Leukemia

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Drugs & Therapeutics for Central Nervous System Leukemia

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Drug clinical trials:

Search ClinicalTrials for Central Nervous System Leukemia

Search NIH Clinical Center for Central Nervous System Leukemia

Genetic Tests for Central Nervous System Leukemia

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Anatomical Context for Central Nervous System Leukemia

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MalaCards organs/tissues related to Central Nervous System Leukemia:

31
Bone, Brain, Myeloid

FMA organs/tissues related to Central Nervous System Leukemia:

14
The central nervous system

Animal Models for Central Nervous System Leukemia or affiliated genes

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Publications for Central Nervous System Leukemia

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Articles related to Central Nervous System Leukemia:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Establishment of NOD/SCID mouse model of central nervous system leukemia. (24927394)
2014
2
Comprehensive craniospinal radiation for controlling central nervous system leukemia. (25539370)
2014
3
Does VEGF secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight-junction proteins in central nervous system leukemia? (21398042)
2011
4
Controversies in the management of central nervous system leukemia. (20469977)
2010
5
Prophylaxis of central nervous system leukemia: a case of chronic myeloid leukemia with lymphoid blast crisis treated with imatinib mesylate. (18661773)
2008
6
Central nervous system leukemia on magnetic resonance imaging. (18310989)
2008
7
Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy. (17487757)
2007
8
Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae. (17924103)
2007
9
Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction. (15681484)
2005
10
Primary central nervous system leukemia with a novel chromosomal translocation. (9335020)
1997
11
Central nervous system leukemia. (8868094)
1996
12
Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin. (7537120)
1995
13
The role of systemic high-dose cytarabine in the treatment of central nervous system leukemia. Clinical results in 46 patients. (8319175)
1993
14
Temporal bone findings in central nervous system leukemia. (1812774)
1991
15
Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia. (1901928)
1991
16
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia. (2323651)
1990
17
Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia. (3052630)
1988
18
Intermittent central nervous system irradiation and intrathecal chemotherapy for central nervous system leukemia in children. (3624023)
1987
19
Significance of cerebrospinal fluid ferritin estimation in central nervous system leukemia. (3113843)
1987
20
Elevation of cerebrospinal fluid sialic acid concentration in children with central nervous system leukemia. (3296627)
1987
21
Millipore filter vs cytocentrifuge for detection of childhood central nervous system leukemia. (2425776)
1986
22
Pickwickian syndrome related to central nervous system leukemia. (3458358)
1986
23
Central nervous system leukemia in children with acute nonlymphoblastic leukemia. (3840394)
1985
24
The central nervous system leukemia: a clinical and pathological study. (3860195)
1985
25
A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22). (3857943)
1985
26
Recognition of central nervous system leukemia by flow cytometry. (6596184)
1984
27
Sequential combination of systemic high-dose ara-C and asparaginase for the treatment of central nervous system leukemia and lymphoma. (6366149)
1984
28
Diabetes insipidus associated with central nervous system leukemia. (7123345)
1982
29
Central nervous system leukemia and lymphoma: computed tomographic manifestations. (6976091)
1981
30
Scanning electron microscopic study on central nervous system leukemia in children. (292293)
1979
31
Intraventricular versus intralumbar methotrexate for central-nervous-system leukemia: prolonged remission with the Ommaya reservoir. (288969)
1979
32
Central nervous system leukemia. (267618)
1977
33
Cerebrospinal fluid polyamine monitoring in central nervous system leukemia. (852128)
1977
34
Central nervous system leukemia in childhood. (927864)
1977
35
Antimetaboliths in the prophylaxis and treatment of central nervous system leukemia. (267507)
1977
36
Complications of intrathecal methotrexate prophylaxis and treatment of central nervous system leukemia in children. (1071901)
1976
37
Adult central nervous system leukemia: incidence and clinicopathologic features. (822517)
1976
38
Preventing central nervous system leukemia. (990041)
1976
39
Disseminated necrotizing leukoencephalopathy: a complication of treated central nervous system leukemia and lymphoma. (1053934)
1975
40
A murine model for central nervous system leukemia and its possible relevance to human leukemia. (1159838)
1975
41
Leukoencephalopathy following combined therapy of central nervous system leukemia and lymphoma. (1057358)
1975
42
Central nervous system leukemia. (1094335)
1975
43
Comparison of two methods of preventing central nervous system leukemia. (4516522)
1973
44
Factors that influence the appearance of central nervous system leukemia. (4519105)
1973
45
Prevention of central nervous system leukemia by irradiation. (4516634)
1973
46
Cytocentrifugation in the management of central nervous system leukemia. (4343831)
1972
47
Proceedings: Prognosis in central nervous system leukemia. (4764928)
1972
48
Central nervous system leukemia in children. (5058828)
1972
49
The increasing incidence of central nervous system leukemia in children. (Children's Cancer Study Group A). (5271211)
1970
50
Central nervous system leukemia and solid tumors of childhood. Treatment with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU). (4288265)
1966

Variations for Central Nervous System Leukemia

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Expression for genes affiliated with Central Nervous System Leukemia

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Search GEO for disease gene expression data for Central Nervous System Leukemia.

Pathways for genes affiliated with Central Nervous System Leukemia

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Pathways related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7TNF
2
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.0IL1B, TNF
3
Show member pathways
9.0TNF, IL1B
49.0IL1B, TNF
5
Show member pathways
Alzheimers Disease36
9.0IL1B, TNF
69.0TNF, IL1B
79.0IL1B, TNF
89.0TNF, IL1B
9
Show member pathways
9.0IL1B, TNF
10
Show member pathways
9.0TNF, IL1B
119.0IL1B, TNF
12
Show member pathways
MAPK signaling pathway36
9.0IL1B, TNF
13
Show member pathways
9.0IL1B, TNF
14
Show member pathways
9.0IL1B, TNF
15
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0IL1B, TNF
16
Show member pathways
9.0TNF, IL1B
17
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.0IL1B, TNF
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.0TNF, IL1B
19
Show member pathways
9.0IL1B, TNF
209.0IL1B, TNF
21
Show member pathways
Immune response MIF in innate immunity response58
9.0TNF, IL1B
229.0TNF, IL1B
239.0IL1B, TNF
249.0IL1B, TNF
259.0TNF, IL1B
269.0TNF, IL1B
27
Show member pathways
Serotonin Transporter Activity36
9.0TNF, IL1B
289.0IL1B, TNF
299.0IL1B, TNF
309.0TNF, IL1B
31
Show member pathways
IL27-mediated signaling events36
9.0TNF, IL1B
329.0IL1B, TNF
33
Show member pathways
9.0TNF, IL1B
349.0TNF, IL1B
359.0IL1B, TNF
369.0TNF, IL1B
37
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.0TNF, IL1B
389.0TNF, IL1B
399.0IL1B, TNF
40
Show member pathways
thioredoxin pathway36
9.0IL1B, TNF
419.0IL1B, TNF

Compounds for genes affiliated with Central Nervous System Leukemia

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Compounds related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1tenidap43 2810.5IL1B, TNF
2n,n-dimethylsphingosine43 5910.5TNF, IL1B
3cicaprost43 2810.5IL1B, TNF
4anakinra43 1210.5TNF, IL1B
5taurine chloramine439.5TNF, IL1B
6vesnarinone439.5TNF, IL1B
7toxin-1439.5TNF, IL1B
8actinomycin439.5TNF, IL1B
9mip 1alpha439.5TNF, IL1B
10gold sodium thiomalate439.5TNF, IL1B
11ro 31 8220439.5TNF, IL1B
12il-12439.5IL1B, TNF
135 aminosalicylic acid439.4IL1B, TNF
14staurosporin439.4TNF, IL1B
15tpck439.4IL1B, TNF
16polymyxin b439.4TNF, IL1B
17groalpha439.4TNF, IL1B
18leflunomide43 49 1211.4IL1B, TNF
19triptolide439.4IL1B, TNF
20gm-csf43 2810.4TNF, IL1B
21ciglitazone43 2810.4IL1B, TNF
22budesonide43 49 1211.4IL1B, TNF
23sulfasalazine28 43 49 1212.4IL1B, TNF
24lipoteichoic acid439.4TNF, IL1B
25fluticasone propionate43 49 59 1212.4IL1B, TNF
26ns 39843 5910.4IL1B, TNF
27polyinosinic-polycytidylic acid439.4IL1B, TNF
28ndga439.4IL1B, TNF
29etanercept43 49 1211.4TNF, IL1B
30poly(i-c)439.4TNF, IL1B
31il 10439.4TNF, IL1B
32l-nmma439.4IL1B, TNF
33diphenyleneiodonium439.3TNF, IL1B
34infliximab43 49 1211.3IL1B, TNF
35peptidoglycan43 2810.3TNF, IL1B
36ivig439.3TNF, IL1B
37ccl343 2810.3IL1B, TNF
38pentoxifylline43 1210.3IL1B, TNF
39c2ceramide439.3TNF, IL1B
40neopterin439.3TNF, IL1B
4115-deoxy-delta-12,14-prostaglandin j2439.2TNF, IL1B
42pdtc439.2TNF, IL1B
43anisomycin43 1210.2TNF, IL1B
44thalidomide43 49 59 1212.1IL1B, TNF
45leukotriene b443 59 2411.1IL1B, TNF
46sp 60012543 5910.0IL1B, TNF
47mg 13243 5910.0IL1B, TNF
48prostacyclin439.0ASRGL1, TNF, IL1B
49hydrocortisone43 2 59 1211.9TNF, IL1B
50troglitazone43 28 59 1211.7IL1B, TNF

GO Terms for genes affiliated with Central Nervous System Leukemia

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Biological processes related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:00307309.4IL1B, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:00605599.4IL1B, TNF
3positive regulation of heterotypic cell-cell adhesionGO:00341169.4TNF, IL1B
4positive regulation of fever generationGO:00316229.4TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:00450809.4IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.4IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:00510449.4TNF, IL1B
8negative regulation of lipid catabolic processGO:00509959.4IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:00423469.4IL1B, TNF
10lipopolysaccharide-mediated signaling pathwayGO:00316639.3IL1B, TNF
11positive regulation of mitosisGO:00458409.3TNF, IL1B
12protein kinase B signalingGO:00434919.3IL1B, TNF
13positive regulation of nitric oxide biosynthetic processGO:00454299.3IL1B, TNF
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.3TNF, IL1B
15cellular response to organic cyclic compoundGO:00714079.3IL1B, TNF
16positive regulation of interferon-gamma productionGO:00327299.3IL1B, TNF
17positive regulation of interleukin-6 productionGO:00327559.3TNF, IL1B
18positive regulation of JNK cascadeGO:00463309.2IL1B, TNF
19MAPK cascadeGO:00001659.2IL1B, TNF
20regulation of insulin secretionGO:00507969.2TNF, IL1B
21activation of MAPK activityGO:00001879.1IL1B, TNF
22positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.1IL1B, TNF
23positive regulation of protein phosphorylationGO:00019349.0TNF, IL1B
24inflammatory responseGO:00069549.0IL1B, TNF
25positive regulation of NF-kappaB transcription factor activityGO:00510928.9IL1B, TNF
26positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431238.7IL1B, TNF

Molecular functions related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0IL1B, TNF

Products for genes affiliated with Central Nervous System Leukemia

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Sources for Central Nervous System Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet