MCID: CNT018
MIFTS: 41

Central Nervous System Leukemia malady

Neuronal diseases category

Summaries for Central Nervous System Leukemia

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A hematologic cancer located in the central nervous system.

MalaCards: Central Nervous System Leukemia, also known as leukemia of the cns, is related to leukemia and acute leukemia. An important gene associated with Central Nervous System Leukemia is IL1B (interleukin 1, beta), and among its related pathways are Toll Comparative Pathway and Amoebiasis. The compounds n,n-dimethylsphingosine and anakinra have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system, myeloid and t cells.

Aliases & Classifications for Central Nervous System Leukemia

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

central nervous system leukemia 8 10 60
leukemia of the cns 8


External Ids:

Disease Ontology8 DOID:12969
NCIt39 C5440

Related Diseases for Central Nervous System Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Central Nervous System Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia11.0
2acute leukemia10.6
3childhood leukemia10.5
4central nervous system lymphoma10.4
5acute lymphocytic leukemia10.3
6lymphoid leukemia10.1
7diabetes insipidus10.1
8chronic myeloid leukemia10.1
9adult acute lymphocytic leukemia10.1
10central nervous system cancer10.1
11lymphoblastic leukemia10.1
12myeloid leukemia10.1
13nervous system cancer10.1
14severe combined immunodeficiency10.1
15degenerative disc disease10.0IL1B
16poems syndrome10.0IL1B
17bacterial vaginosis10.0IL1B
18pleurisy10.0IL1B
19gingival overgrowth10.0IL1B
20mastitis10.0IL1B
21toxic encephalopathy10.0IL1B
22psoriatic arthritis10.0TNF
23otitis media10.0IL1B
24acquired immunodeficiency syndrome10.0IL1B
25eye disease10.0IL1B
26blau syndrome10.0TNF, IL1B
27arthritis10.0TNF, IL1B
28cerebral malaria10.0IL1B, TNF
29aids dementia complex10.0IL1B, TNF
30adult respiratory distress syndrome10.0IL1B, TNF
31periodontitis10.0IL1B, TNF
32toxic shock syndrome10.0TNF, IL1B
33chorioamnionitis10.0IL1B, TNF
34periodontal disease10.0TNF, IL1B
35septic shock10.0IL1B, TNF
36arthropathy10.0IL1B, TNF
37familial mediterranean fever10.0IL1B, TNF
38respiratory failure10.0IL1B, TNF
39congenital heart defect10.0IL1B, TNF
40interstitial lung disease10.0TNF, IL1B
41monocytic leukemia10.0TNF, IL1B
42hypersensitivity reaction type ii disease10.0IL1B, TNF
43cork-handlers' disease10.0IL1B, TNF
44synovitis10.0IL1B, TNF

Graphical network of the top 20 diseases related to Central Nervous System Leukemia:



Diseases related to central nervous system leukemia

Clinical Features for Central Nervous System Leukemia

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Drugs & Therapeutics for Central Nervous System Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Nervous System Leukemia

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Leukemia

Search NIH Clinical Center for Central Nervous System Leukemia

Search CenterWatch for Central Nervous System Leukemia

Genetic Tests for Central Nervous System Leukemia

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Anatomical Context for Central Nervous System Leukemia

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Central Nervous System Leukemia:

32
Myeloid, T cells, Bone, Bone marrow, Monocytes, Brain, B cells, Endothelial

FMA organs/tissues related to Central Nervous System Leukemia:

14
The central nervous system

Animal Models for Central Nervous System Leukemia or affiliated genes

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Publications for Central Nervous System Leukemia

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Sources:
50PubMed
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Articles related to Central Nervous System Leukemia:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
50 years ago in the journal of pediatrics: central nervous system complications of children with acute leukemia: an evaluation of treatment methods. (24359900)
2014
2
Tailored central nervous system-directed treatment strategy for isolated CNS recurrence of adult acute myeloid leukemia. (24074528)
2013
3
Mutant DNMT3A clone evading chemotherapy and infiltrating central nervous system in a patient with molecularly good-risk acute myeloid leukemia. (24337413)
2013
4
De Novo B-Cell Prolymphocytic Leukemia with Central Nervous System Involvement. (24047478)
2013
5
Isolated central nervous system relapse presenting as myeloid sarcoma of acute myeloid leukemia after allogeneic peripheral blood stem cell transplantation. (22878457)
2013
6
Central nervous system involvement of epstein barr virus associated lymphoproliferative disorder in a child with acute lymphoblastic leukemia: successful treatment with rituximab and interferon-alpha. (24385755)
2013
7
Dasatinib maintenance therapy after allogeneic hematopoietic stem cell transplantation for an isolated central nervous system blast crisis in chronic myelogenous leukemia. (23548721)
2013
8
Pattern and determinants of central nervous system relapse in childhood acute lymphoblastic leukemia in a resource-limited setting. (23878491)
2013
9
FLT3 internal tandem duplication is associated with a high relapse rate and central nervous system involvement in acute promyelocytic leukemia cases: single institutional analysis. (21129033)
2011
10
Does VEGF secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight-junction proteins in central nervous system leukemia? (21398042)
2011
11
Clinical efficacy of arsenic trioxide in a patient with acute promyelocytic leukemia with recurrent central nervous system involvement. (20721555)
2011
12
Acute promyelocytic leukemia presenting with central nervous system involvement: a report of 2 cases. (21239864)
2011
13
Comparison of birth weight corrected for gestational age and birth weight alone in prediction of development of childhood leukemia and central nervous system tumors. (19813253)
2010
14
Controversies in the management of central nervous system leukemia. (20469977)
2010
15
MRI of central nervous system abnormalities in childhood leukemia. (19517377)
2009
16
Epididymo-orchitis and central nervous system nocardiosis in a bone marrow transplant recipient for acute lymphoblastic leukemia. (20353380)
2009
17
Central nervous system leukemia on magnetic resonance imaging. (18310989)
2008
18
Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation. (17109389)
2007
19
Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. (17405266)
2006
20
Central nervous system disease in acute lymphoblastic leukemia: prophylaxis and treatment. (17124053)
2006
21
Hypermethylation of CpG island in the promoter region of CALCA in acute lymphoblastic leukemia with central nervous system (CNS) infiltration correlates with poorer prognosis. (16712930)
2006
22
Double leukemias simultaneously showing lymphoblastic leukemia of the bone marrow and monocytic leukemia of the central nervous system. (14978698)
2004
23
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate. (14581336)
2003
24
Adult T-cell leukemia (ATL) cells which express neural cell adhesion molecule (NCAM) and infiltrate into the central nervous system. (11838588)
2002
25
Central nervous system leukemia recurring over more than 16 years. (10797368)
2000
26
Interactions between brain endothelial cells and human T-cell leukemia virus type 1-infected lymphocytes: mechanisms of viral entry into the central nervous system. (10846084)
2000
27
Extramedullary tumor of monoblasts in the central nervous system: presenting feature of simultaneous bone marrow involvement by acute monocytic leukemia. (10320145)
1999
28
Serum adenosine deaminase and arylsulphatase A as an index of early infiltration of central nervous system in acute lymphoblastic leukemia. (17249214)
1998
29
Primary central nervous system leukemia with a novel chromosomal translocation. (9335020)
1997
30
Craniospinal irradiation for acute lymphoblastic leukemia with central nervous system disease at diagnosis: a report from the Children's Cancer Group. (8823255)
1996
31
Childhood leukemia: central nervous system abnormalities during and after treatment. (8938302)
1996
32
Central nervous system leukemia. (8868094)
1996
33
Adult T-cell leukemia involving the central nervous system after remission of adult respiratory distress syndrome. (8252991)
1993
34
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia. (2323651)
1990
35
Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia. (3052630)
1988
36
Central nervous system leukemia. (3047654)
1988
37
Intermittent central nervous system irradiation and intrathecal chemotherapy for central nervous system leukemia in children. (3624023)
1987
38
Elevation of cerebrospinal fluid sialic acid concentration in children with central nervous system leukemia. (3296627)
1987
39
Recognition of central nervous system leukemia by flow cytometry. (6596184)
1984
40
Giant cell granulomatous angiitis of the central nervous system in a patient with leukemia and cutaneous herpes zoster. (6702756)
1984
41
Sequential combination of systemic high-dose ara-C and asparaginase for the treatment of central nervous system leukemia and lymphoma. (6366149)
1984
42
Aziridinylbenzoquinone (AZQ) treatment of central nervous system leukemia. (6958367)
1982
43
Scanning electron microscopic study on central nervous system leukemia in children. (292293)
1979
44
Central nervous system leukemia. (267618)
1977
45
Cerebrospinal fluid polyamine monitoring in central nervous system leukemia. (852128)
1977
46
Adult central nervous system leukemia: incidence and clinicopathologic features. (822517)
1976
47
Treatment of central nervous system leukemia with intrathecal cytosine arabinoside. (4201653)
1973
48
Factors that influence the appearance of central nervous system leukemia. (4519105)
1973
49
Central nervous system leukemia in children. (5058828)
1972
50
The increasing incidence of central nervous system leukemia in children. (Children's Cancer Study Group A). (5271211)
1970

Genetic Variations for Central Nervous System Leukemia

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Expression for genes affiliated with Central Nervous System Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Leukemia

Search GEO for disease gene expression data for Central Nervous System Leukemia.

Pathways for genes affiliated with Central Nervous System Leukemia

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Sources:
51QIAGEN, 12EMD Millipore, 29KEGG, 4Cell Signaling Technology, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.0IL1B, TNF
29.0IL1B, TNF
39.0IL1B, TNF
49.0TNF, IL1B
59.0IL1B, TNF
6
Hide members
9.0IL1B, TNF
79.0TNF, IL1B
89.0IL1B, TNF
9
Hide members
9.0IL1B, TNF
109.0IL1B, TNF
11
Development PDGF signaling via STATs and NF-kB
Hide members
9.0IL1B, TNF
12
Hide members
9.0TNF, IL1B
13
Hide members
9.0IL1B, TNF
149.0IL1B, TNF
159.0TNF, IL1B
169.0TNF, IL1B
179.0IL1B, TNF
189.0IL1B, TNF
199.0IL1B, TNF
209.0TNF, IL1B
219.0IL1B, TNF
229.0IL1B, TNF
239.0TNF, IL1B
249.0IL1B, TNF
25
Immune response Bacterial infections in normal airways
Hide members
9.0IL1B, TNF
269.0IL1B, TNF
27
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.0TNF, IL1B
289.0IL1B, TNF
29
Hide members
9.0IL1B, TNF
309.0IL1B, TNF

Compounds for genes affiliated with Central Nervous System Leukemia

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1n,n-dimethylsphingosine44 5910.5IL1B, TNF
2anakinra44 1110.5TNF, IL1B
3cicaprost44 2810.5TNF, IL1B
4taurine chloramine449.5TNF, IL1B
5vesnarinone449.5TNF, IL1B
6toxin-1449.5IL1B, TNF
7mip 1alpha449.5TNF, IL1B
8actinomycin449.5TNF, IL1B
9gold sodium thiomalate449.5IL1B, TNF
10ro 31 8220449.5IL1B, TNF
11il-12449.5TNF, IL1B
125 aminosalicylic acid449.5TNF, IL1B
13staurosporin449.4IL1B, TNF
14tpck449.4IL1B, TNF
15polymyxin b449.4TNF, IL1B
16leflunomide49 44 1111.4IL1B, TNF
17groalpha449.4IL1B, TNF
18triptolide449.4TNF, IL1B
19gm-csf44 2810.4TNF, IL1B
20budesonide44 49 1111.4TNF, IL1B
21ciglitazone44 2810.4TNF, IL1B
22lipoteichoic acid449.4IL1B, TNF
23sulfasalazine44 28 49 1112.4IL1B, TNF
24fluticasone propionate44 49 59 1112.4TNF, IL1B
25ns 39844 5910.4IL1B, TNF
26polyinosinic-polycytidylic acid449.4IL1B, TNF
27ndga449.4IL1B, TNF
28etanercept44 49 1111.4TNF, IL1B
29poly(i-c)449.4IL1B, TNF
30il 10449.4IL1B, TNF
31l-nmma449.4TNF, IL1B
32infliximab44 49 1111.4TNF, IL1B
33diphenyleneiodonium449.3IL1B, TNF
34peptidoglycan44 2810.3TNF, IL1B
35ivig449.3IL1B, TNF
36ccl344 2810.3IL1B, TNF
37c2ceramide449.3TNF, IL1B
38neopterin449.3IL1B, TNF
3915-deoxy-delta-12,14-prostaglandin j2449.3IL1B, TNF
40pdtc449.3TNF, IL1B
41thalidomide44 49 59 1112.2IL1B, TNF
42anisomycin44 1110.2IL1B, TNF
43leukotriene b444 59 2411.2TNF, IL1B
44sp 60012544 5910.1IL1B, TNF
45hydrocortisone44 2 59 1112.1IL1B, TNF
46troglitazone44 28 59 1112.0TNF, IL1B
47herbimycin a44 5910.0IL1B, TNF
48prostacyclin449.0ASRGL1, IL1B, TNF
49mg 13244 599.9IL1B, TNF
50tgf beta1448.7IL1B, TNF

GO Terms for genes affiliated with Central Nervous System Leukemia

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16Gene Ontology
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Biological processes related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:0307309.4IL1B, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4IL1B, TNF
3positive regulation of heterotypic cell-cell adhesionGO:0341169.4IL1B, TNF
4positive regulation of fever generationGO:0316229.4TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:0450809.4IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.4IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, IL1B
8negative regulation of lipid catabolic processGO:0509959.4IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:0423469.3IL1B, TNF
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3TNF, IL1B
11lipopolysaccharide-mediated signaling pathwayGO:0316639.3IL1B, TNF
12positive regulation of mitosisGO:0458409.3IL1B, TNF
13cellular response to organic cyclic compoundGO:0714079.3TNF, IL1B
14protein kinase B signaling cascadeGO:0434919.3IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.3IL1B, TNF
16positive regulation of interferon-gamma productionGO:0327299.3TNF, IL1B
17positive regulation of interleukin-6 productionGO:0327559.2IL1B, TNF
18positive regulation of JNK cascadeGO:0463309.2IL1B, TNF
19MAPK cascadeGO:0001659.2TNF, IL1B
20positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL1B, TNF
21regulation of insulin secretionGO:0507969.1IL1B, TNF
22positive regulation of protein phosphorylationGO:0019349.0TNF, IL1B
23positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.0IL1B, TNF
24activation of MAPK activityGO:0001878.9IL1B, TNF
25positive regulation of NF-kappaB transcription factor activityGO:0510928.7IL1B, TNF

Products for genes affiliated with Central Nervous System Leukemia

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Sources for Central Nervous System Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet