MCID: CNT018
MIFTS: 38

Central Nervous System Leukemia malady

Neuronal category

Summaries for Central Nervous System Leukemia

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A hematologic cancer located in the central nervous system.

MalaCards: Central Nervous System Leukemia, also known as leukemia of the cns, is related to acute leukemia and central nervous system lymphoma. An important gene associated with Central Nervous System Leukemia is IL1B (interleukin 1, beta), and among its related pathways are Toll Comparative Pathway and Amoebiasis. The compounds n,n-dimethylsphingosine and anakinra have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system, brain and bone marrow.

Aliases & Classifications for Central Nervous System Leukemia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

central nervous system leukemia 8 10 61
leukemia of the cns 8


External Ids:

Disease Ontology8 DOID:12969
NCIt40 C5440

Related Diseases for Central Nervous System Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Central Nervous System Leukemia:



Diseases related to central nervous system leukemia

Clinical Features for Central Nervous System Leukemia

Drugs & Therapeutics for Central Nervous System Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Nervous System Leukemia

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Leukemia

Search NIH Clinical Center for Central Nervous System Leukemia

Search CenterWatch for Central Nervous System Leukemia

Genetic Tests for Central Nervous System Leukemia

Anatomical Context for Central Nervous System Leukemia

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Central Nervous System Leukemia:

33
Brain, Bone marrow, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

FMA organs/tissues related to Central Nervous System Leukemia:

14
The central nervous system

Animal Models for Central Nervous System Leukemia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Central Nervous System Leukemia

Sources:
51PubMed
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Articles related to Central Nervous System Leukemia:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Safety and tolerability of intrathecal liposomal cytarabine as central nervous system prophylaxis in patients with acute lymphoblastic leukemia. (24138308)
2013
2
Mutant DNMT3A clone evading chemotherapy and infiltrating central nervous system in a patient with molecularly good-risk acute myeloid leukemia. (24337413)
2013
3
Central nervous system relapse in acute promyelocytic leukemia: a single institution experience. (23469963)
2013
4
De Novo B-Cell Prolymphocytic Leukemia with Central Nervous System Involvement. (24047478)
2013
5
Unrelated cord blood transplantation for central nervous system relapse in high-risk childhood acute lymphoblastic leukemia. (23793915)
2013
6
Dasatinib maintenance therapy after allogeneic hematopoietic stem cell transplantation for an isolated central nervous system blast crisis in chronic myelogenous leukemia. (23548721)
2013
7
A practical strategy of monitoring minimal residue disease and intervention for central nervous system relapse of childhood acute lymphoblastic leukemia: a single Chinese center's experience. (23787730)
2013
8
Pattern and determinants of central nervous system relapse in childhood acute lymphoblastic leukemia in a resource-limited setting. (23878491)
2013
9
FLT3 internal tandem duplication is associated with a high relapse rate and central nervous system involvement in acute promyelocytic leukemia cases: single institutional analysis. (21129033)
2011
10
Does VEGF secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight-junction proteins in central nervous system leukemia? (21398042)
2011
11
Epstein-Barr virus-associated primary central nervous system lymphoma in a patient with adult T-cell leukemiaa88/a88lymphoma. (21366675)
2011
12
Controversies in the management of central nervous system leukemia. (20469977)
2010
13
Isolated central nervous system relapse in an adolescent with acute myelomonocytic leukemia, Charcot Marie Tooth syndrome, and paraneoplastic autoantibody. (20724950)
2010
14
MRI of central nervous system abnormalities in childhood leukemia. (19517377)
2009
15
The first case of de novo B-cell prolymphocytic leukemia with central nervous system involvement: description of an unreported complication. (18929411)
2009
16
Prophylaxis of central nervous system leukemia: a case of chronic myeloid leukemia with lymphoid blast crisis treated with imatinib mesylate. (18661773)
2008
17
Central nervous system leukemia on magnetic resonance imaging. (18310989)
2008
18
Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy. (17487757)
2007
19
Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation. (17109389)
2007
20
Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. (17405266)
2006
21
Central nervous system disease in acute lymphoblastic leukemia: prophylaxis and treatment. (17124053)
2006
22
Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction. (15681484)
2005
23
Methotrexate infusions as central nervous system prophylaxis in children with acute lymphocytic leukemia: the Norwegian experience. (12637215)
2003
24
Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis. (13129766)
2003
25
Central nervous system involvement of Epstein-Barr virus lymphoproliferative disease in a patient with acute lymphocytic leukemia. (10779033)
2000
26
Inappropriate secretion of antidiuretic hormone as the initial sign of central nervous system progression of nocardiosis in a patient with chronic lymphocytic leukemia. (10586219)
1999
27
Primary central nervous system leukemia with a novel chromosomal translocation. (9335020)
1997
28
Childhood leukemia: central nervous system abnormalities during and after treatment. (8938302)
1996
29
Central nervous system leukemia. (8868094)
1996
30
Molecular evidence for central nervous system involvement in children with newly diagnosed acute lymphoblastic leukemia. (7557896)
1995
31
Central nervous system leukostasis in patients with leukemias and lymphomas. (8673423)
1995
32
Efficacy of intrathecal methotrexate with and without cranial radiotherapy in preventing central nervous system relapses in acute lymphocytic leukemia. (1428132)
1992
33
Temporal bone findings in central nervous system leukemia. (1812774)
1991
34
Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia. (1901928)
1991
35
Primary central nervous system lymphoma as a variant of Richter's syndrome in two patients with chronic lymphocytic leukemia. (2766225)
1989
36
Central nervous system involvement in a patient with chronic lymphocytic leukemia and non-Hodgkin's lymphoma (Richter's syndrome), with concordant cell surface immunoglobulin isotypic and immunophenotypic markers. (3341285)
1988
37
Intermittent central nervous system irradiation and intrathecal chemotherapy for central nervous system leukemia in children. (3624023)
1987
38
Elevation of cerebrospinal fluid sialic acid concentration in children with central nervous system leukemia. (3296627)
1987
39
Central nervous system involvement as a presenting feature of acute monocytic leukemia: preceding leukemia by 12 months. (6576628)
1983
40
Reduction in central nervous system leukemia with a pharmacokinetically derived intrathecal methotrexate dosage regimen. (6366138)
1983
41
Central nervous system leukemia and lymphoma: computed tomographic manifestations. (6976091)
1981
42
Central nervous system leukemia. (267618)
1977
43
Central nervous system leukemia in childhood. (927864)
1977
44
Adult central nervous system leukemia: incidence and clinicopathologic features. (822517)
1976
45
The pathologic characteristics of leukostasis and leukemic nodules occurring in the central nervous system of guinea pigs with L2C/NB leukemia. (1245856)
1976
46
Leukoencephalopathy following combined therapy of central nervous system leukemia and lymphoma. (1057358)
1975
47
Central nervous system leukemia. (1094335)
1975
48
Factors that influence the appearance of central nervous system leukemia. (4519105)
1973
49
Cytocentrifugation in central nervous system leukemia. (4572939)
1973
50
Proceedings: Prognosis in central nervous system leukemia. (4764928)
1972

Genetic Variations for Central Nervous System Leukemia

Expression for genes affiliated with Central Nervous System Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Central Nervous System Leukemia

Search GEO for disease gene expression data for Central Nervous System Leukemia.

Pathways for genes affiliated with Central Nervous System Leukemia

Sources:
52QIAGEN, 12EMD Millipore, 30KEGG, 4Cell Signaling Technology, 54Reactome, 38NCBI BioSystems Database, 53R&D Systems
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Pathways related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.0IL1B, TNF
29.0IL1B, TNF
39.0IL1B, TNF
49.0TNF, IL1B
59.0IL1B, TNF
6
Hide members
9.0IL1B, TNF
79.0TNF, IL1B
89.0IL1B, TNF
9
Hide members
9.0IL1B, TNF
109.0IL1B, TNF
11
Development PDGF signaling via STATs and NF-kB
Hide members
9.0IL1B, TNF
12
Hide members
9.0TNF, IL1B
13
Hide members
9.0IL1B, TNF
149.0IL1B, TNF
159.0TNF, IL1B
169.0TNF, IL1B
179.0IL1B, TNF
189.0IL1B, TNF
199.0IL1B, TNF
209.0TNF, IL1B
219.0IL1B, TNF
229.0IL1B, TNF
239.0TNF, IL1B
249.0IL1B, TNF
25
Immune response Bacterial infections in normal airways
Hide members
9.0IL1B, TNF
269.0IL1B, TNF
27
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.0TNF, IL1B
289.0IL1B, TNF
29
Hide members
9.0IL1B, TNF
309.0IL1B, TNF

Compounds for genes affiliated with Central Nervous System Leukemia

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1n,n-dimethylsphingosine45 6010.5IL1B, TNF
2anakinra45 1110.5TNF, IL1B
3cicaprost45 2910.5TNF, IL1B
4taurine chloramine459.5TNF, IL1B
5vesnarinone459.5TNF, IL1B
6toxin-1459.5IL1B, TNF
7mip 1alpha459.5TNF, IL1B
8actinomycin459.5TNF, IL1B
9gold sodium thiomalate459.5IL1B, TNF
10ro 31 8220459.5IL1B, TNF
11il-12459.5TNF, IL1B
125 aminosalicylic acid459.5TNF, IL1B
13staurosporin459.4IL1B, TNF
14tpck459.4IL1B, TNF
15polymyxin b459.4TNF, IL1B
16leflunomide50 45 1111.4IL1B, TNF
17groalpha459.4IL1B, TNF
18triptolide459.4TNF, IL1B
19gm-csf45 2910.4TNF, IL1B
20budesonide45 50 1111.4TNF, IL1B
21ciglitazone45 2910.4TNF, IL1B
22lipoteichoic acid459.4IL1B, TNF
23sulfasalazine45 29 50 1112.4IL1B, TNF
24fluticasone propionate45 50 60 1112.4TNF, IL1B
25ns 39845 6010.4IL1B, TNF
26polyinosinic-polycytidylic acid459.4IL1B, TNF
27ndga459.4IL1B, TNF
28etanercept45 50 1111.4TNF, IL1B
29poly(i-c)459.4IL1B, TNF
30il 10459.4IL1B, TNF
31l-nmma459.4TNF, IL1B
32infliximab45 50 1111.4TNF, IL1B
33diphenyleneiodonium459.3IL1B, TNF
34peptidoglycan45 2910.3TNF, IL1B
35ivig459.3IL1B, TNF
36ccl345 2910.3IL1B, TNF
37c2ceramide459.3TNF, IL1B
38neopterin459.3IL1B, TNF
3915-deoxy-delta-12,14-prostaglandin j2459.3IL1B, TNF
40pdtc459.3TNF, IL1B
41thalidomide45 50 60 1112.2IL1B, TNF
42anisomycin45 1110.2IL1B, TNF
43leukotriene b445 60 2411.2TNF, IL1B
44sp 60012545 6010.1IL1B, TNF
45hydrocortisone45 2 60 1112.1IL1B, TNF
46troglitazone45 29 60 1112.0TNF, IL1B
47herbimycin a45 6010.0IL1B, TNF
48prostacyclin459.0ASRGL1, IL1B, TNF
49mg 13245 609.9IL1B, TNF
50tgf beta1458.7IL1B, TNF

GO Terms for genes affiliated with Central Nervous System Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:0307309.4IL1B, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4IL1B, TNF
3positive regulation of heterotypic cell-cell adhesionGO:0341169.4IL1B, TNF
4positive regulation of fever generationGO:0316229.4TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:0450809.4IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.4IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, IL1B
8negative regulation of lipid catabolic processGO:0509959.4IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:0423469.3IL1B, TNF
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3TNF, IL1B
11lipopolysaccharide-mediated signaling pathwayGO:0316639.3IL1B, TNF
12positive regulation of mitosisGO:0458409.3IL1B, TNF
13cellular response to organic cyclic compoundGO:0714079.3TNF, IL1B
14protein kinase B signaling cascadeGO:0434919.3IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.3IL1B, TNF
16positive regulation of interferon-gamma productionGO:0327299.3TNF, IL1B
17positive regulation of interleukin-6 productionGO:0327559.2IL1B, TNF
18positive regulation of JNK cascadeGO:0463309.2IL1B, TNF
19MAPK cascadeGO:0001659.2TNF, IL1B
20positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL1B, TNF
21regulation of insulin secretionGO:0507969.1IL1B, TNF
22positive regulation of protein phosphorylationGO:0019349.0TNF, IL1B
23positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.0IL1B, TNF
24activation of MAPK activityGO:0001878.9IL1B, TNF
25positive regulation of NF-kappaB transcription factor activityGO:0510928.7IL1B, TNF

Products for genes affiliated with Central Nervous System Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Nervous System Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet