MCID: CNT018
MIFTS: 41

Central Nervous System Leukemia malady

Neuronal diseases, Cancer diseases categories
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Summaries for Central Nervous System Leukemia

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A hematologic cancer located in the central nervous system.

MalaCards: Central Nervous System Leukemia, also known as leukemia of the cns, is related to leukemia and acute leukemia. An important gene associated with Central Nervous System Leukemia is IL1B (interleukin 1, beta), and among its related pathways are TRAF Pathway and Immune response IL 23 signaling pathway. The compounds n,n-dimethylsphingosine and tenidap have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system, brain and bone.

Aliases & Classifications for Central Nervous System Leukemia

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8Disease Ontology, 10DISEASES, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

central nervous system leukemia 8 10 62
leukemia of the cns 8


External Ids:

Disease Ontology8 DOID:12969
NCIt40 C5440

Related Diseases for Central Nervous System Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Central Nervous System Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.5IL1B, ASRGL1, TNF
2acute leukemia10.3
3acute lymphocytic leukemia10.3
4diabetes insipidus10.2
5chronic myeloid leukemia10.2
6lymphoblastic leukemia10.2
7myeloid leukemia10.2
8severe combined immunodeficiency10.2
9acute myelomonocytic leukemia10.2
10malaria10.1TNF
11degenerative disc disease10.1IL1B
12skin disease10.1IL1B
13blau syndrome10.0TNF, IL1B
14aids dementia complex10.0IL1B, TNF
15familial mediterranean fever10.0TNF, IL1B
16chorioamnionitis10.0IL1B, TNF
17interstitial lung disease10.0IL1B, TNF
18psoriatic arthritis10.0TNF, IL1B
19cerebral malaria10.0IL1B, TNF
20toxic shock syndrome10.0IL1B, TNF
21adult respiratory distress syndrome10.0IL1B, TNF
22respiratory failure10.0IL1B, TNF
23peritonitis10.0TNF, IL1B
24periodontitis10.0TNF, IL1B
25arthropathy10.0IL1B, TNF
26synovitis10.0TNF, IL1B
27monocytic leukemia10.0IL1B, TNF
28periodontal disease10.0TNF, IL1B
29septic shock10.0IL1B, TNF
30hypersensitivity reaction type ii disease10.0IL1B, TNF
31galactosemia10.0IL1B, TNF
32sarcoidosis10.0TNF, IL1B
33primary hyperoxaluria10.0IL1B, TNF
34congenital heart disease10.0TNF, IL1B
35cork-handlers' disease10.0TNF, IL1B
36pneumonia10.0IL1B, TNF
37vascular disease10.0IL1B, TNF
38pancreatitis10.0ASRGL1, IL1B
39ulcerative colitis10.0IL1B, TNF
40sepsis10.0IL1B, TNF
41inflammatory bowel disease10.0TNF, IL1B
42tuberculosis10.0IL1B, TNF
43osteoarthritis10.0TNF, IL1B
44arthritis10.0IL1B, TNF
45psoriasis10.0IL1B, TNF
46multiple sclerosis9.9IL1B, TNF

Graphical network of the top 20 diseases related to Central Nervous System Leukemia:



Diseases related to central nervous system leukemia

Symptoms for Central Nervous System Leukemia

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Drugs & Therapeutics for Central Nervous System Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Central Nervous System Leukemia

Search NIH Clinical Center for Central Nervous System Leukemia

Genetic Tests for Central Nervous System Leukemia

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Anatomical Context for Central Nervous System Leukemia

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Central Nervous System Leukemia:

33
Brain, Bone, Myeloid

FMA organs/tissues related to Central Nervous System Leukemia:

14
The central nervous system

Animal Models for Central Nervous System Leukemia or affiliated genes

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Publications for Central Nervous System Leukemia

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Sources:
52PubMed
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Articles related to Central Nervous System Leukemia:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Does VEGF secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight-junction proteins in central nervous system leukemia? (21398042)
2011
2
Controversies in the management of central nervous system leukemia. (20469977)
2010
3
Prophylaxis of central nervous system leukemia: a case of chronic myeloid leukemia with lymphoid blast crisis treated with imatinib mesylate. (18661773)
2008
4
Central nervous system leukemia on magnetic resonance imaging. (18310989)
2008
5
Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy. (17487757)
2007
6
Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae. (17924103)
2007
7
Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction. (15681484)
2005
8
Central nervous system leukemia recurring over more than 16 years. (10797368)
2000
9
Primary central nervous system leukemia with a novel chromosomal translocation. (9335020)
1997
10
Central nervous system leukemia. (8868094)
1996
11
Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin. (7537120)
1995
12
The role of systemic high-dose cytarabine in the treatment of central nervous system leukemia. Clinical results in 46 patients. (8319175)
1993
13
Temporal bone findings in central nervous system leukemia. (1812774)
1991
14
Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia. (1901928)
1991
15
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia. (2323651)
1990
16
Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia. (3052630)
1988
17
Intermittent central nervous system irradiation and intrathecal chemotherapy for central nervous system leukemia in children. (3624023)
1987
18
Significance of cerebrospinal fluid ferritin estimation in central nervous system leukemia. (3113843)
1987
19
Elevation of cerebrospinal fluid sialic acid concentration in children with central nervous system leukemia. (3296627)
1987
20
Millipore filter vs cytocentrifuge for detection of childhood central nervous system leukemia. (2425776)
1986
21
Pickwickian syndrome related to central nervous system leukemia. (3458358)
1986
22
Central nervous system leukemia in children with acute nonlymphoblastic leukemia. (3840394)
1985
23
The central nervous system leukemia: a clinical and pathological study. (3860195)
1985
24
A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22). (3857943)
1985
25
Recognition of central nervous system leukemia by flow cytometry. (6596184)
1984
26
Sequential combination of systemic high-dose ara-C and asparaginase for the treatment of central nervous system leukemia and lymphoma. (6366149)
1984
27
Diabetes insipidus associated with central nervous system leukemia. (7123345)
1982
28
Central nervous system leukemia and lymphoma: computed tomographic manifestations. (6976091)
1981
29
Scanning electron microscopic study on central nervous system leukemia in children. (292293)
1979
30
Intraventricular versus intralumbar methotrexate for central-nervous-system leukemia: prolonged remission with the Ommaya reservoir. (288969)
1979
31
Central nervous system leukemia. (267618)
1977
32
Cerebrospinal fluid polyamine monitoring in central nervous system leukemia. (852128)
1977
33
Central nervous system leukemia in childhood. (927864)
1977
34
Antimetaboliths in the prophylaxis and treatment of central nervous system leukemia. (267507)
1977
35
Complications of intrathecal methotrexate prophylaxis and treatment of central nervous system leukemia in children. (1071901)
1976
36
Adult central nervous system leukemia: incidence and clinicopathologic features. (822517)
1976
37
Preventing central nervous system leukemia. (990041)
1976
38
Disseminated necrotizing leukoencephalopathy: a complication of treated central nervous system leukemia and lymphoma. (1053934)
1975
39
A murine model for central nervous system leukemia and its possible relevance to human leukemia. (1159838)
1975
40
Leukoencephalopathy following combined therapy of central nervous system leukemia and lymphoma. (1057358)
1975
41
Central nervous system leukemia. (1094335)
1975
42
Treatment of central nervous system leukemia with intrathecal cytosine arabinoside. (4201653)
1973
43
Comparison of two methods of preventing central nervous system leukemia. (4516522)
1973
44
Factors that influence the appearance of central nervous system leukemia. (4519105)
1973
45
Prevention of central nervous system leukemia by irradiation. (4516634)
1973
46
Cytocentrifugation in the management of central nervous system leukemia. (4343831)
1972
47
Proceedings: Prognosis in central nervous system leukemia. (4764928)
1972
48
Central nervous system leukemia in children. (5058828)
1972
49
The increasing incidence of central nervous system leukemia in children. (Children's Cancer Study Group A). (5271211)
1970
50
Central nervous system leukemia and solid tumors of childhood. Treatment with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU). (4288265)
1966

Variations for Central Nervous System Leukemia

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Expression for genes affiliated with Central Nervous System Leukemia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Leukemia

Search GEO for disease gene expression data for Central Nervous System Leukemia.

Pathways for genes affiliated with Central Nervous System Leukemia

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Sources:
50PathCards, 53QIAGEN, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 54R&D Systems, 5Cell Signaling Technology
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Pathways related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7TNF
2
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0IL1B, TNF
3
Show member pathways
9.0TNF, IL1B
49.0IL1B, TNF
5
Show member pathways
Alzheimers Disease38
9.0IL1B, TNF
69.0TNF, IL1B
79.0IL1B, TNF
89.0TNF, IL1B
9
Show member pathways
9.0IL1B, TNF
10
Show member pathways
9.0TNF, IL1B
119.0IL1B, TNF
12
Show member pathways
MAPK signaling pathway38
9.0IL1B, TNF
13
Show member pathways
9.0IL1B, TNF
14
Show member pathways
9.0IL1B, TNF
15
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0IL1B, TNF
16
Show member pathways
9.0TNF, IL1B
17
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.0IL1B, TNF
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.0TNF, IL1B
19
Show member pathways
9.0IL1B, TNF
209.0IL1B, TNF
21
Show member pathways
Immune response MIF in innate immunity response60
9.0TNF, IL1B
229.0TNF, IL1B
239.0IL1B, TNF
249.0IL1B, TNF
259.0TNF, IL1B
269.0TNF, IL1B
27
Show member pathways
Serotonin Transporter Activity38
9.0TNF, IL1B
289.0IL1B, TNF
299.0IL1B, TNF
309.0TNF, IL1B
31
Show member pathways
IL27-mediated signaling events38
9.0TNF, IL1B
329.0IL1B, TNF
33
Show member pathways
9.0TNF, IL1B
349.0TNF, IL1B
359.0IL1B, TNF
369.0TNF, IL1B
37
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0TNF, IL1B
389.0TNF, IL1B
399.0IL1B, TNF
40
Show member pathways
thioredoxin pathway38
9.0IL1B, TNF
419.0IL1B, TNF

Compounds for genes affiliated with Central Nervous System Leukemia

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1n,n-dimethylsphingosine45 6110.5TNF, IL1B
2tenidap45 2910.5TNF, IL1B
3anakinra45 1110.5IL1B, TNF
4cicaprost45 2910.5IL1B, TNF
5vesnarinone459.5TNF, IL1B
6taurine chloramine459.5TNF, IL1B
7toxin-1459.5IL1B, TNF
8mip 1alpha459.5TNF, IL1B
9actinomycin459.5TNF, IL1B
10gold sodium thiomalate459.5IL1B, TNF
11ro 31 8220459.5TNF, IL1B
12il-12459.5IL1B, TNF
135 aminosalicylic acid459.4IL1B, TNF
14staurosporin459.4TNF, IL1B
15tpck459.4IL1B, TNF
16polymyxin b459.4IL1B, TNF
17groalpha459.4TNF, IL1B
18leflunomide45 51 1111.4TNF, IL1B
19triptolide459.4IL1B, TNF
20gm-csf45 2910.4IL1B, TNF
21ciglitazone45 2910.4TNF, IL1B
22budesonide45 51 1111.4TNF, IL1B
23sulfasalazine29 45 51 1112.4TNF, IL1B
24lipoteichoic acid459.4TNF, IL1B
25fluticasone propionate45 51 61 1112.4IL1B, TNF
26ns 39845 6110.4IL1B, TNF
27polyinosinic-polycytidylic acid459.4TNF, IL1B
28ndga459.4IL1B, TNF
29etanercept45 51 1111.4IL1B, TNF
30poly(i-c)459.4IL1B, TNF
31il 10459.4TNF, IL1B
32l-nmma459.4IL1B, TNF
33diphenyleneiodonium459.3IL1B, TNF
34infliximab45 51 1111.3TNF, IL1B
35peptidoglycan45 2910.3IL1B, TNF
36ivig459.3IL1B, TNF
37ccl345 2910.3TNF, IL1B
38pentoxifylline45 1110.3TNF, IL1B
39c2ceramide459.3IL1B, TNF
40neopterin459.3IL1B, TNF
4115-deoxy-delta-12,14-prostaglandin j2459.2TNF, IL1B
42pdtc459.2IL1B, TNF
43anisomycin45 1110.2IL1B, TNF
44thalidomide45 51 61 1112.1TNF, IL1B
45leukotriene b445 61 2411.1IL1B, TNF
46sp 60012545 6110.0IL1B, TNF
47mg 13245 6110.0IL1B, TNF
48prostacyclin459.0IL1B, ASRGL1, TNF
49hydrocortisone45 3 61 1111.9TNF, IL1B
50troglitazone45 29 61 1111.7IL1B, TNF

GO Terms for genes affiliated with Central Nervous System Leukemia

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16Gene Ontology
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Biological processes related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:0307309.4IL1B, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4IL1B, TNF
3positive regulation of heterotypic cell-cell adhesionGO:0341169.4TNF, IL1B
4positive regulation of fever generationGO:0316229.4TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:0450809.4IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.4IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, IL1B
8negative regulation of lipid catabolic processGO:0509959.4IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:0423469.4IL1B, TNF
10lipopolysaccharide-mediated signaling pathwayGO:0316639.3IL1B, TNF
11positive regulation of mitosisGO:0458409.3TNF, IL1B
12protein kinase B signalingGO:0434919.3IL1B, TNF
13positive regulation of nitric oxide biosynthetic processGO:0454299.3IL1B, TNF
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3TNF, IL1B
15cellular response to organic cyclic compoundGO:0714079.3IL1B, TNF
16positive regulation of interferon-gamma productionGO:0327299.3IL1B, TNF
17positive regulation of interleukin-6 productionGO:0327559.3TNF, IL1B
18positive regulation of JNK cascadeGO:0463309.2IL1B, TNF
19MAPK cascadeGO:0001659.2IL1B, TNF
20regulation of insulin secretionGO:0507969.2TNF, IL1B
21activation of MAPK activityGO:0001879.1IL1B, TNF
22positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL1B, TNF
23positive regulation of protein phosphorylationGO:0019349.0TNF, IL1B
24inflammatory responseGO:0069549.0IL1B, TNF
25positive regulation of NF-kappaB transcription factor activityGO:0510928.9IL1B, TNF
26positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.7IL1B, TNF

Molecular functions related to Central Nervous System Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL1B, TNF

Products for genes affiliated with Central Nervous System Leukemia

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  • Antibodies
  • Proteins
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Sources for Central Nervous System Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet