MCID: CNT005
MIFTS: 56

Central Nervous System Lymphoma malady

Neuronal diseases, Immune diseases categories

Summaries for Central Nervous System Lymphoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A hematologic cancer that has material basis in lymphoma located in central nervous system.

MalaCards: Central Nervous System Lymphoma, also known as primary central nervous system lymphoma, is related to intraocular lymphoma and central nervous system lymphoma, primary. An important gene associated with Central Nervous System Lymphoma is IGHM (immunoglobulin heavy constant mu), and among its related pathways are DEx/H-box helicases activate type I IFN and inflammatory cytokines production and IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation. The compounds rantes and peg-10 have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, b cells and t cells, and related mouse phenotypes are endocrine/exocrine gland and no phenotypic analysis.

Aliases & Classifications for Central Nervous System Lymphoma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Immune diseases


Aliases & Descriptions:

central nervous system lymphoma 8 10 60
primary central nervous system lymphoma 60
primary cns lymphoma 8
microglioma 8


External Ids:

Disease Ontology8 DOID:3234
NCIt39 C9301
ICD9CM27 200.5

Related Diseases for Central Nervous System Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Central Nervous System Lymphoma family:

Central Nervous System Lymphoma, Primary

Diseases related to Central Nervous System Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1intraocular lymphoma31.0CXCR5
2central nervous system lymphoma, primary30.8TIMP3, MGMT, PIM1, IGHM, CXCR5, CXCL13
3multiple sclerosis30.6TIMP3, CCL21, TNFRSF13C, CXCR5, CXCL13
4arthritis30.2TIMP3
5gastric lymphoma30.2BCL10, BCL6
6hepatitis b30.2IGHM, MYD88
7rheumatoid arthritis30.2TIMP3, TNFRSF13C, IGHM, CXCR5
8macroglobulinemia30.2PAX5
9hodgkin's lymphoma30.2PRDM1, IGHM, PAX5, BCL6
10herpes simplex30.2IRF7
11chronic lymphocytic leukemia30.2CCL19, TNFRSF13C, IGHM, CXCR5, PAX5, BCL6
12breast cancer30.2TIMP3, CCL21, PRDX4, BCL6, SDC1
13sjogren's syndrome30.2CXCL13, CCL21
14leukemia30.2MGMT, PIM1, PRDX4, PRDM1, CXCR5, DAPK1
15hepatitis c30.2TIMP3, IRF7, BCL6
16central nervous system cancer10.6
17central nervous system disease10.6
18nervous system cancer10.6
19nervous system disease10.6
20diffuse large b-cell lymphoma10.6
21adult lymphoma10.5
22meningitis10.5
23testicular lymphoma10.4
24cerebral lymphoma10.4
25encephalitis10.4
26retinitis10.4
27neurofibromatosis10.3
28richter's syndrome10.3
29cerebritis10.3
30panhypopituitarism10.3
31liver lymphoma10.3
32acquired immunodeficiency syndrome10.3
33hepatitis a10.3
34hepatitis10.3
35central retinal artery occlusion10.1
36autoimmune thyroiditis10.1
37bardet-biedl syndrome10.1
38klinefelter's syndrome10.1
39choroiditis10.1
40posterior scleritis10.1
41thyroid lymphoma10.1
42common variable immunodeficiency10.1
43wegener's granulomatosis10.1
44pancytopenia10.1
45pituitary apoplexy10.1
46diabetes insipidus10.1
47bone lymphoma10.1
48central nervous system leukemia10.1
49lyme disease10.1
50progressive multifocal leukoencephalopathy10.1

Graphical network of the top 20 diseases related to Central Nervous System Lymphoma:



Diseases related to central nervous system lymphoma

Clinical Features for Central Nervous System Lymphoma

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Drugs & Therapeutics for Central Nervous System Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Central Nervous System Lymphoma

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Lymphoma

Search NIH Clinical Center for Central Nervous System Lymphoma

Search CenterWatch for Central Nervous System Lymphoma

Genetic Tests for Central Nervous System Lymphoma

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Anatomical Context for Central Nervous System Lymphoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Central Nervous System Lymphoma:

32
B cells, T cells, Brain, Endothelial, Liver, Spinal cord, Kidney, Breast, Pituitary, Tonsil, Nk cells, Hypothalamus, Bone, Monocytes, Testis, Thyroid, Bone marrow, Lymph node, Occipital lobe

FMA organs/tissues related to Central Nervous System Lymphoma:

14
Central nervous system

Animal Models for Central Nervous System Lymphoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Central Nervous System Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.3PRDM1, PRDX4, MGMT
2MP:00030129.8MGMT, PIM1, PRDX4, PRDM1, IGHM, MYD88
3MP:00053879.8SDC1, TIMP3, CCL19, TNFRSF13C, IRF7, PIM1
4MP:00053849.8IGHM, PRDM1, PRDX4, PIM1, TNFRSF13C, TIMP3
5MP:00053979.8TIMP3, CCL19, TNFRSF13C, PIM1, PRDM1, IGHM

Publications for Central Nervous System Lymphoma

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Sources:
50PubMed
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Articles related to Central Nervous System Lymphoma:

(show top 50)    (show all 654)
idTitleAuthorsYear
1
Is there a role for radiotherapy in the primary management of primary central nervous system lymphoma? A single-centre case series. (23688624)
2013
2
Secondary central nervous system involvement in 599 patients with diffuse large B-cell lymphoma: are there any changes in the rituximab era? (24234713)
2013
3
Central nervous system involvement in anaplastic large cell lymphoma in childhood: results from a multicentre European and Japanese study. (23720354)
2013
4
Primary central nervous system lymphoma with ocular involvement. (23579601)
2013
5
Local recurrence of primary central nervous system lymphoma due to tumor seeding. (23793439)
2013
6
Factors associated with survival among patients with AIDS-related primary central nervous system lymphoma. (24076659)
2013
7
Conservative management of post-transplant central nervous system lymphoma. (22476860)
2013
8
18F-FDG PET in the diagnosis and treatment of primary central nervous system lymphoma. (23844359)
2013
9
Predictors of central nervous system involvement in diffuse large B-cell lymphoma: a divining rod is wanted. (24106437)
2013
10
Low frequency of blood group A in secondary central nervous system lymphoma. (23050209)
2012
11
A single centre study of the treatment of relapsed primary central nervous system lymphoma (PCNSL) with single agent temozolomide. (22995759)
2012
12
Central nervous system lymphoma: characteristic findings on traditional and advanced imaging. (20616176)
2011
13
Primary central nervous system lymphoma in acquired immune deficiency syndrome mimicking toxoplasmosis. (21210240)
2011
14
Primary central nervous system lymphoma: a study of clinicopathological features and trend in western India. (21768666)
2011
15
YKL-40 and MMP-9 as serum markers for patients with primary central nervous system lymphoma. (21391238)
2011
16
Comparison of 11C-methionine PET and 18F-FDG PET in patients with primary central nervous system lymphoma. (21042866)
2011
17
Improved survival with combined chemo-radiotherapy in primary central nervous system lymphoma. (20890070)
2010
18
Whole brain radiation alone produces favourable outcomes for AIDS-related primary central nervous system lymphoma in the HAART era. (20132301)
2010
19
Expression of signal transducer and activator of transcription 3 (STAT3) in primary central nervous system diffuse large B-cell lymphoma: a retrospective analysis of 17 cases. (20446017)
2010
20
Biology and treatment of primary central nervous system lymphoma. (19560747)
2009
21
High-dose chemotherapy supported by autologous stem cell transplantation in patients with primary central nervous system lymphoma: facts and opinions. (19021047)
2008
22
Cultured human endothelial cells expressing HIV-1 Vpu and Tat support the expansion of malignant B cells from primary central nervous system lymphoma. (18227216)
2008
23
Primary central nervous system lymphoma: monocenter, long-term, intent-to-treat analysis. (18318432)
2008
24
Central nervous system lymphoma in a patient with Sjogren's syndrome and autoimmune thyroiditis (Hashimoto's thyroiditis). (16941199)
2007
25
Primary central nervous system lymphoma treated with rituximab plus temozolomide in a second line schedule. (17652061)
2007
26
Diagnostic and surgical pitfalls of an unusual primary central nervous system lymphoma. (17935030)
2007
27
Treatment of primary central nervous system lymphoma. (17580007)
2007
28
Primary central nervous system lymphoma: biological aspects and controversies in management. (17433666)
2007
29
Delayed [(18)F]FDG PET imaging of central nervous system lymphoma: is PET better than MRI? (16850335)
2006
30
Secondary central nervous system lymphoma. (16926134)
2006
31
Unusual uterine recurrence of primary central nervous system lymphoma. (17099627)
2006
32
Primary malignant lymphoma of the central nervous system in an immunocompetent child: a case report. (16217262)
2005
33
Meeting report: primary central nervous system lymphoma: standards of care and future perspectives. (15692223)
2005
34
Salmonella meningitis in an adult patient with central nervous system lymphoma. (16137560)
2005
35
Update on primary central nervous system lymphoma. (16280675)
2005
36
Primary central nervous system lymphoma (PCNSL) in immunocompetent adults: analysis of a retrospective series of patients treated using idarubicin-containing regimen and radiotherapy. (15448676)
2004
37
Primary central nervous system lymphoma in Japan 1995-1999: changes from the preceding 10 years. (15034788)
2004
38
Pseudouveitis: a clue to the diagnosis of primary central nervous system lymphoma in immunocompetent patients. (15232310)
2004
39
Positive predictive value of Epstein-Barr virus DNA detection in HIV-related primary central nervous system lymphoma. (15494920)
2004
40
Treatment of primary central nervous system lymphoma. (15497122)
2004
41
Primary central nervous system lymphoma in Korea: comparison of B- and T-cell lymphomas. (12826884)
2003
42
Is whole-brain irradiation necessary for primary central nervous system lymphoma? Patterns of recurrence after partial-brain irradiation. (12491514)
2003
43
Primary central nervous system cytotoxic/suppressor T-cell lymphoma: report of a unique case and review of the literature. (12717253)
2003
44
Association of total dose intensity of chemotherapy in primary central nervous system lymphoma (human non-acquired immunodeficiency syndrome) and survival. (11334269)
2001
45
Cerebrospinal fluid interleukin-10 levels in primary central nervous system lymphoma: a possible marker of response to treatment? (10632117)
2000
46
Radiotherapy in the treatment of primary central nervous system lymphoma (PCNSL). (10563430)
1999
47
Primary central nervous system lymphomas--new pathological developments. (8523072)
1995
48
A clinicopathological study of 21 cases of primary central nervous system lymphoma]. (8090264)
1994
49
Lymphomatoid granulomatosis and malignant lymphoma of the central nervous system in the acquired immunodeficiency syndrome. (2703227)
1989
50
Disseminated necrotizing leukoencephalopathy: a complication of treated central nervous system leukemia and lymphoma. (1053934)
1975

Genetic Variations for Central Nervous System Lymphoma

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Expression for genes affiliated with Central Nervous System Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Lymphoma

Search GEO for disease gene expression data for Central Nervous System Lymphoma.

Pathways for genes affiliated with Central Nervous System Lymphoma

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Sources:
53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 29KEGG
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Pathways related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IRF7, MYD88
2
Hide members
10.4IRF7, MYD88
310.3DAPK1, MGMT, BCL6
410.3IRF7, BCL10, MYD88
5
Hide members
10.3BCL10, TIMP3, TNFRSF13C, MYD88
6
Apoptosis and survival Lymphotoxin-beta receptor signaling
Hide members
10.3CCL21, CCL19, CXCL13
710.2CXCL13, CXCR5, CCL21, CCL19
8
Hide members
10.2CCL19, CCL21, CXCR5, CXCL13
9
Hide members
10.2CXCL13, TNFRSF13C, CCL19, TIMP3, CCL21
1010.2CCL19, BCL10, CCL21, TNFRSF13C, MYD88
11
Hide members
10.2CCL21, CCL19, CXCL13, MYD88, TIMP3, TNFRSF13C
1210.2PRDM1, PIM1, PAX5, BCL10, BCL6, MYD88
13
Hide members
10.1CCL19, CXCR5, PIM1, CXCL13, TNFRSF13C, CCL21

Compounds for genes affiliated with Central Nervous System Lymphoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1rantes4410.6IRF7, CXCR5
2peg-104410.6CXCL13, CXCR5, CCL19
3o6-methylguanine4410.5DAPK1, MGMT, TIMP3
4teck4410.5CXCL13, CCL21, CCL19
5mip-3beta4410.5CCL19, CCL21
6cytidine44 11 2412.4BCL6, PAX5, PRDM1
7larc4410.4CCL21, CCL19
8serine4410.3IRF7, PIM1, PRDX4, DAPK1, BCL10
912-o-tetradecanoylphorbol 13-acetate4410.3TIMP3, IRF7, MGMT, BCL6
10calcium44 49 11 2413.2TIMP3, CCL19, CCL21, TNFRSF13C, MGMT, PIM1
11oligonucleotide4410.2TIMP3, IRF7, MGMT, MYD88, PAX5
12sodium bisulfite4410.1DAPK1, MGMT

GO Terms for genes affiliated with Central Nervous System Lymphoma

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16Gene Ontology
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Biological processes related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycoprotein biosynthetic processGO:01056010.7CCL21, CCL19
2immunological synapse formationGO:00177110.6CCL19, CCL21
3establishment of T cell polarityGO:00176810.6CCL21, CCL19
4negative regulation of leukocyte apoptotic processGO:200010710.6CCL21, CCL19
5response to prostaglandin E stimulusGO:03469510.6CCL19, CCL21
6positive regulation of dendritic cell antigen processing and presentationGO:00260610.6CCL21, CCL19
7germinal center formationGO:00246710.6BCL6, CXCL13
8positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.6BCL10, MYD88, CCL21, CCL19
9positive regulation of cell motilityGO:200014710.5CCL19, CCL21
10T cell costimulationGO:03129510.5CCL19, CCL21, TNFRSF13C
11immune responseGO:00695510.5CCL19, CCL21, IGHM, CXCR5, CXCL13
12positive regulation of chemotaxisGO:05092110.5CCL19, CCL21
13immunoglobulin mediated immune responseGO:01606410.5BCL10, IRF7
14lymph node developmentGO:04853510.4CXCR5, CXCL13
15positive regulation of receptor-mediated endocytosisGO:04826010.4CCL19, CCL21
16positive regulation of neutrophil chemotaxisGO:09002310.4CCL21, CCL19
17dendritic cell chemotaxisGO:00240710.3CCL21, CCL19
18toll-like receptor signaling pathwayGO:00222410.0BCL10, MYD88, IRF7

Molecular functions related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.3CXCL13, CCL21, CCL19
2CCR7 chemokine receptor bindingGO:03173210.3CCL21, CCL19
3CCR10 chemokine receptor bindingGO:03173510.1CXCL13, CCL19

Products for genes affiliated with Central Nervous System Lymphoma

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  • Antibodies
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  • Antibodies

Sources for Central Nervous System Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet