MCID: CNT005
MIFTS: 45

Central Nervous System Lymphoma malady

Neuronal diseases, Immune diseases, Rare diseases, Blood diseases, Cancer diseases categories

Summaries for Central Nervous System Lymphoma

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Disease Ontology:9 A hematologic cancer that has material basis in lymphoma located in central nervous system.

MalaCards based summary: Central Nervous System Lymphoma, also known as primary central nervous system lymphoma, is related to macroglobulinemia and hodgkin lymphoma. An important gene associated with Central Nervous System Lymphoma is IGHM (immunoglobulin heavy constant mu), and among its related pathways is Selected targets of p53. The compounds sodium bisulfite and 5-methylcytosine have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, brain and b cells, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Central Nervous System Lymphoma

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Central Nervous System Lymphoma, Aliases & Descriptions:

Name: Central Nervous System Lymphoma 9 11 60
Primary Central Nervous System Lymphoma 60
 
Primary Cns Lymphoma 9
Microglioma 9


Classifications:



External Ids:

Disease Ontology9 DOID:3234
ICD9CM27 200.5
NCIt38 C9301

Related Diseases for Central Nervous System Lymphoma

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Diseases in the Central Nervous System Lymphoma family:

Central Nervous System Lymphoma, Primary

Diseases related to Central Nervous System Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1macroglobulinemia31.0PAX5
2hodgkin lymphoma30.6IGHM, PAX5, PRDM1
3central nervous system lymphoma, primary30.6PAX5, TIMP3, IGHM, MGMT, DAPK1
4chronic lymphocytic leukemia30.4PAX5, IGHM
5hepatitis c30.4IRF7, TIMP3
6follicular lymphoma30.4PAX5, TNFRSF13C, IGHM
7rheumatoid arthritis30.1IGHM, TNFRSF13C, TIMP3, CHI3L1
8glioblastoma30.0MGMT, TIMP3, CHI3L1
9leukemia29.9PRDM1, PAX5, MGMT, DAPK1
10b-cell lymphomas29.7DAPK1, MGMT, IGHM, TNFRSF13C, PAX5, PRDM1
11intraocular lymphoma10.5
12meningitis10.5
13endotheliitis10.5
14acquired immunodeficiency syndrome10.4
15encephalitis10.4
16retinitis10.4
17neurofibromatosis, type 110.3
18arthritis10.3
19diffuse large b-cell lymphoma10.3
20hepatitis10.3
21richter's syndrome10.3
22neurofibromatosis10.3
23cerebritis10.3
24lupus nephritis10.3
25nephritis10.3
26waldenstrom macroglobulinemia10.3PAX5, IGHM
27gastritis10.3TIMP3, MGMT
28pilocytic astrocytoma10.2TIMP3, MGMT
29cholangiocarcinoma10.2TIMP3, DAPK1
30breast cancer10.2
31hepatitis c virus10.2
32renal cell carcinoma10.2
33hiv-110.2
34common variable immunodeficiency10.2
35hematopoietic stem cell transplantation10.2
36hepatitis b10.2
37myasthenia gravis10.2
38testicular lymphoma10.2
39klinefelter's syndrome10.2
40bardet-biedl syndrome10.2
41autoimmune thyroiditis10.2
42pituitary apoplexy10.2
43diabetes insipidus10.2
44meningoencephalitis10.2
45lyme disease10.2
46progressive multifocal leukoencephalopathy10.2
47polycystic kidney disease10.2
48tonsillitis10.2
49cauda equina syndrome10.2
50retinal vasculitis10.2

Graphical network of the top 20 diseases related to Central Nervous System Lymphoma:



Diseases related to central nervous system lymphoma

Symptoms for Central Nervous System Lymphoma

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Drugs & Therapeutics for Central Nervous System Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Central Nervous System Lymphoma

Search NIH Clinical Center for Central Nervous System Lymphoma

Genetic Tests for Central Nervous System Lymphoma

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Anatomical Context for Central Nervous System Lymphoma

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MalaCards organs/tissues related to Central Nervous System Lymphoma:

31
Brain, B cells, Endothelial, T cells, Kidney, Liver, Pituitary, Bone marrow, Bone, Lymph node, Spinal cord, Thyroid, Breast, Tonsil, Monocytes, Nk cells, Occipital lobe, Hypothalamus

FMA organs/tissues related to Central Nervous System Lymphoma:

14
Central nervous system

Animal Models for Central Nervous System Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Central Nervous System Lymphoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.7PRDM1, TIMP3, IGHM, MGMT
2MP:00053678.5DAPK1, IGHM, TIMP3, PRDM1
3MP:00053847.5DAPK1, IGHM, TIMP3, PAX5, CHI3L1, PRDM1
4MP:00053767.3DAPK1, MGMT, IGHM, TNFRSF13C, TIMP3, IRF7
5MP:00053977.1PRDM1, IGHM, TNFRSF13C, TIMP3, PAX5, IRF7
6MP:00053877.0IGHM, TNFRSF13C, TIMP3, PAX5, IRF7, CHI3L1

Publications for Central Nervous System Lymphoma

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Articles related to Central Nervous System Lymphoma:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Cytomegalovirus meningoencephalitis after rituximab treatment for primary central nervous system lymphoma. (25607329)
2015
2
Treatment of patients with secondary central nervous system lymphoma with high-dose busulfan/thiotepa-based conditioning and autologous stem cell transplant. (25747968)
2015
3
New approaches in primary central nervous system lymphoma. (25841718)
2015
4
Primary central nervous system lymphoma in a rheumatoid arthritis patient treated with methotrexate: a case report. (25888766)
2015
5
Central nervous system lymphoma: patterns of incidence in Indian population and effect of steroids on stereotactic biopsy yield. (25033875)
2014
6
Mechanisms of intracerebral lymphoma growth delineated in a syngeneic mouse model of central nervous system lymphoma. (23481709)
2013
7
Is there a role for radiotherapy in the primary management of primary central nervous system lymphoma? A single-centre case series. (23688624)
2013
8
Recent advances in treatment of primary central nervous system lymphoma. (23934511)
2013
9
Utility of flow cytometry of cerebrospinal fluid as a screening tool in the diagnosis of central nervous system lymphoma. (24168498)
2013
10
Advantages of dose-dense methotrexate protocol for primary central nervous system lymphoma: comparison of two different protocols at a single institution. (24162244)
2013
11
Primary central nervous system lymphoma and meningioma in DOTATATE PET/CT. (24152642)
2013
12
Interleukin-8 in the pathogenesis of primary central nervous system lymphoma in association with HIV infection. (22664113)
2012
13
Relapse pattern and prognostic factors for patients with primary central nervous system lymphoma. (22479279)
2012
14
Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma. (22563813)
2012
15
Low frequency of blood group A in secondary central nervous system lymphoma. (23050209)
2012
16
Primary central nervous system lymphoma masquerading as bilateral vitreous floaters. (22498134)
2012
17
MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma. (22729947)
2012
18
Central nervous system lymphoma: characteristic findings on traditional and advanced imaging. (20616176)
2011
19
Survival among patients with primary central nervous system lymphoma, 1973-2004. (20556477)
2011
20
Primary central nervous system lymphoma in acquired immune deficiency syndrome mimicking toxoplasmosis. (21210240)
2011
21
Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells. (20872671)
2010
22
Somatic mutations altering Tyr641 of EZH2 are rare in primary central nervous system lymphoma. (20858097)
2010
23
Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma. (19494841)
2009
24
Insights into the biology of primary central nervous system lymphoma. (19080745)
2009
25
Preferential expression of truncated isoforms of FOXP1 in primary central nervous system lymphoma. (19680146)
2009
26
Primary central nervous system lymphoma mimicking pituitary apoplexy: case report. (18205050)
2009
27
Ocular central nervous system lymphoma mimicking choroidal neovascularization. (18435341)
2008
28
Testicular relapse of primary central nervous system lymphoma. (17487747)
2007
29
Cognitive functions in primary central nervous system lymphoma: literature review and assessment guidelines. (17284616)
2007
30
Central nervous system lymphoma in a patient with Sjogren's syndrome and autoimmune thyroiditis (Hashimoto's thyroiditis). (16941199)
2007
31
Salvage therapy for primary central nervous system lymphoma with (90)Y-Ibritumomab and Temozolomide. (17245621)
2007
32
Delayed [(18)F]FDG PET imaging of central nervous system lymphoma: is PET better than MRI? (16850335)
2006
33
High-dose methotrexate toxicity in elderly patients with primary central nervous system lymphoma. (15653703)
2005
34
Primary Central Nervous System Lymphoma (PCNSL) occurring in pregnancy. (16003500)
2005
35
Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. (16335585)
2005
36
Severe complications after intrathecal methotrexate (MTX) for treatment of primary central nervous system lymphoma (PCNSL). (15003295)
2004
37
Selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles. (12963969)
2003
38
Treatment of primary central nervous system lymphoma in the elderly. (14765387)
2003
39
Long-term remission of primary central nervous system lymphoma by intensified methotrexate chemotherapy. (12814260)
2003
40
Intravitreal methotrexate injections for intraocular involvement in primary central nervous system lymphoma. (14740803)
2003
41
High 123I-IMP retention on SPECT image in primary central nervous system lymphoma. (12675320)
2003
42
Role of intravitreal methotrexate in the management of primary central nervous system lymphoma with ocular involvement. (12208721)
2002
43
Diagnostic advances and new trends for the treatment of primary central nervous system lymphoma. (12091059)
2002
44
Association of total dose intensity of chemotherapy in primary central nervous system lymphoma (human non-acquired immunodeficiency syndrome) and survival. (11334269)
2001
45
Concomitant progressive multifocal leucoencephalopathy and primary central nervous system lymphoma expressing JC virus oncogenic protein, large T antigen. (11577180)
2001
46
Strong correlation between imaging response and survival among patients with primary central nervous system lymphoma: a secondary analysis of RTOG studies 83-15 and 88-06. (10802352)
2000
47
Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type. (10668897)
2000
48
Preclinical primary central nervous system lymphoma. (9101110)
1997
49
A clinicopathological study of 21 cases of primary central nervous system lymphoma]. (8090264)
1994
50
Primary central nervous system lymphoma as a variant of Richter's syndrome in two patients with chronic lymphocytic leukemia. (2766225)
1989

Variations for Central Nervous System Lymphoma

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Cosmic variations for Central Nervous System Lymphoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
143448TNFAIP3haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,primary central nervous system lymphoma2

Expression for genes affiliated with Central Nervous System Lymphoma

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Search GEO for disease gene expression data for Central Nervous System Lymphoma.

Pathways for genes affiliated with Central Nervous System Lymphoma

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Pathways related to Central Nervous System Lymphoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes

Compounds for genes affiliated with Central Nervous System Lymphoma

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Compounds related to Central Nervous System Lymphoma according to GeneCards Suite gene sharing:

(show all 15)
idCompoundScoreTop Affiliating Genes
1sodium bisulfite439.9MGMT, DAPK1
25-methylcytosine43 2410.9MGMT, DAPK1
3crcs439.8DAPK1, MGMT
4cytosine43 2410.6PAX5, MGMT
5o6-methylguanine439.6TIMP3, MGMT, DAPK1
65-aza-2deoxycytidine439.5DAPK1, MGMT, TIMP3
72-methoxyestradiol43 59 2411.5PRDM1, PAX5
8methionine439.5TIMP3, MGMT, DAPK1
9cytidine43 24 1211.4PRDM1, PAX5
10deoxyribonucleic acid439.4TIMP3, MGMT
1112-o-tetradecanoylphorbol 13-acetate439.4MGMT, TIMP3, IRF7
12paraffin439.4MGMT, TIMP3, PAX5
13oligonucleotide439.0MGMT, TIMP3, PAX5, IRF7
14estrogen438.6CHI3L1, TIMP3, MGMT, DAPK1
15calcium43 49 24 1211.5DAPK1, MGMT, TNFRSF13C, TIMP3, PAX5

GO Terms for genes affiliated with Central Nervous System Lymphoma

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Biological processes related to Central Nervous System Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:00001229.0PRDM1, IRF7, PAX5

Molecular functions related to Central Nervous System Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1methyltransferase activityGO:00081689.4PRDM1, MGMT

Products for genes affiliated with Central Nervous System Lymphoma

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  • Antibodies
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  • Antibodies
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  • Kits and Assays

Sources for Central Nervous System Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet