MCID: CNT005
MIFTS: 53

Central Nervous System Lymphoma malady

Neuronal, Immune categories

Summaries for Central Nervous System Lymphoma

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A hematologic cancer that has material basis in lymphoma located in central nervous system.

MalaCards: Central Nervous System Lymphoma, also known as primary central nervous system lymphoma, is related to central nervous system lymphoma, primary and intraocular lymphoma. An important gene associated with Central Nervous System Lymphoma is IGHM (immunoglobulin heavy constant mu), and among its related pathways are DEx/H-box helicases activate type I IFN and inflammatory cytokines production and IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation. The compounds rantes and peg-10 have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, bone marrow and whole blood, and related mouse phenotypes are endocrine/exocrine gland and no phenotypic analysis.

Aliases & Classifications for Central Nervous System Lymphoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Immune


Aliases & Descriptions:

central nervous system lymphoma 8 10 61
primary central nervous system lymphoma 61
primary cns lymphoma 8
microglioma 8


External Ids:

Disease Ontology8 DOID:3234
NCIt40 C9301
ICD9CM27 200.5

Related Diseases for Central Nervous System Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Central Nervous System Lymphoma family:

central nervous system lymphoma, primary

Diseases related to Central Nervous System Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1central nervous system lymphoma, primary32.3TIMP3, MGMT, PIM1, IGHM, CXCR5, CXCL13
2intraocular lymphoma31.1CXCR5
3lymphoma, diffuse large cell30.9PRDM1, PAX5, BCL6
4hepatitis c30.5TIMP3, IRF7, BCL6
5arthritis30.3TIMP3
6gastric lymphoma30.3BCL10, BCL6
7hepatitis b30.3IGHM, MYD88
8macroglobulinemia30.3PAX5
9follicular lymphoma30.3TNFRSF13C, IGHM, CXCR5, PAX5, BCL6, BCL10
10sjogren's syndrome30.3CXCL13, CCL21
11n syndrome10.7
12adult lymphoma10.6
13testicular lymphoma10.5
14primary malignant lymphoma10.5
15retina lymphoma10.4
16cerebral lymphoma10.4
17lymphoma, somatic10.4
18lymphomatous meningitis10.4
19neurofibromatosis10.3
20richter's syndrome10.3
21panhypopituitarism10.3
22liver lymphoma10.3
23central nervous system leukemia10.3
24acquired immunodeficiency syndrome10.3
25lupus nephritis10.3
26hepatitis c virus10.3
27nephritis10.3
28central retinal artery occlusion10.2
29colon lymphoma10.2
30autoimmune thyroiditis10.2
31bardet-biedl syndrome10.2
32klinefelter's syndrome10.2
33posterior scleritis10.2
34thyroid lymphoma10.2
35common variable immunodeficiency10.2
36wegener's granulomatosis10.2
37pancytopenia10.2
38pituitary apoplexy10.2
39diabetes insipidus10.2
40bone lymphoma10.2
41lyme disease10.2
42progressive multifocal leukoencephalopathy10.2
43kaposi's sarcoma10.2
44polycystic kidney disease10.2
45cauda equina syndrome10.2
46breast lymphoma10.2
47pediatric lymphoma10.2
48spinal cord lymphoma10.2
49anaplastic large cell lymphoma10.2
50retinal vasculitis10.2

Graphical network of the top 20 diseases related to Central Nervous System Lymphoma:



Diseases related to central nervous system lymphoma

Clinical Features for Central Nervous System Lymphoma

Drugs & Therapeutics for Central Nervous System Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Central Nervous System Lymphoma

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Lymphoma

Search NIH Clinical Center for Central Nervous System Lymphoma

Search CenterWatch for Central Nervous System Lymphoma

Genetic Tests for Central Nervous System Lymphoma

Anatomical Context for Central Nervous System Lymphoma

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Central Nervous System Lymphoma:

33
Bone marrow, Whole blood, Lymph node, Brain, Spinal cord, Kidney, Liver, Thyroid, Breast, Testis, Tonsil, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Occipital lobe, Hypothalamus, Pituitary

FMA organs/tissues related to Central Nervous System Lymphoma:

14
Central nervous system

Animal Models for Central Nervous System Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Central Nervous System Lymphoma

Sources:
51PubMed
See all sources

Articles related to Central Nervous System Lymphoma:

(show top 50)    (show all 669)
idTitleAuthorsYear
1
Primary central nervous system lymphoma in immunocompetent individuals: a single center experience. (23696924)
2013
2
Advantages of dose-dense methotrexate protocol for primary central nervous system lymphoma: comparison of two different protocols at a single institution. (24162244)
2013
3
Central nervous system involvement in mantle cell lymphoma: clinical features, prognostic factors and outcomes from the European Mantle Cell Lymphoma Network. (23616279)
2013
4
A rare presentation of hypertrophic olivary degeneration secondary to primary central nervous system lymphoma. (23857254)
2013
5
Central nervous system recurrence of systemic lymphoma in the era of stem cell transplantation--an International Primary Central Nervous System Lymphoma Study Group project. (23144196)
2013
6
Gene expression signature-based prognostic risk score in patients with primary central nervous system lymphoma. (22908096)
2012
7
Cerebrospinal fluid interleukin-10 is a potentially useful biomarker in immunocompetent primary central nervous system lymphoma (PCNSL). (22156547)
2012
8
Salvage treatment with temozolomide in refractory or relapsed primary central nervous system lymphoma and assessment of the MGMT status. (21720808)
2012
9
Initial experience with bendamustine in patients with recurrent primary central nervous system lymphoma: a case report. (22249693)
2012
10
Multiple calcified primary central nervous system lymphoma with immunodeficiency in a child. (21633850)
2011
11
Inhibition of eIF4E phosphorylation reduces cell growth and proliferation in primary central nervous system lymphoma cells. (20499137)
2011
12
Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma. (21088137)
2011
13
Use of F-18 FDG PET/CT in non-Hodgkin lymphoma with central nervous system involvement. (21552016)
2011
14
Adult anaplastic large cell lymphoma involving the central nervous system: a rare clinical scenario. (20838823)
2011
15
Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells. (20872671)
2010
16
Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients. (20412122)
2010
17
Imaging in primary central nervous system lymphoma. (24148721)
2010
18
A case with coincidental diagnosis of primary central nervous system lymphoma and lymph node sarcoidosis. (20054702)
2010
19
Primary leptomeningeal central nervous system lymphoma in an immunocompetent adolescent: an unusual presentation. (20464387)
2010
20
Epstein-Barr virus-associated primary central nervous system lymphoma in the Japanese population. (20185874)
2010
21
Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphoma. (20225195)
2010
22
Differential gene expression in central nervous system lymphoma. (19122120)
2009
23
Concurrent renal cell carcinoma and central nervous system lymphoma in a patient with autosomal dominant polycystic kidney disease. (19797927)
2009
24
Atypical presentation of primary central nervous system lymphoma. (19273762)
2009
25
Cognitive functions in primary central nervous system lymphoma: literature review and assessment guidelines. (17284616)
2007
26
Primary central nervous system lymphoma presenting as bilateral tumors of the internal auditory canal. (18449334)
2007
27
Is single-agent temozolomide the treatment of choice for recurrent primary central nervous system lymphoma? (17622233)
2007
28
An update on therapy of primary central nervous system lymphoma. (17124077)
2006
29
Primary central nervous system lymphoma in an Asian population: a 15-year experience. (17028454)
2006
30
Rising incidence of primary central nervous system lymphoma in Kumamoto, Japan. (17084198)
2006
31
Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin. (16489068)
2006
32
Overexpression of c-Myc in primary central nervous system lymphoma of Thais. (17718267)
2006
33
Nonenhancing secondary central nervous system lymphoma. (17091619)
2006
34
High-dose methotrexate toxicity in elderly patients with primary central nervous system lymphoma. (15653703)
2005
35
Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. (16335585)
2005
36
Unusual variants of primary central nervous system lymphoma. (16083828)
2005
37
AIDS-related primary central nervous system lymphoma. (16083829)
2005
38
Update on primary central nervous system lymphoma. (16280675)
2005
39
Advances for the treatment of primary central nervous system lymphoma (review). (15289838)
2004
40
Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. (12393412)
2003
41
Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression. (12657933)
2003
42
Expression of p53, c-Myc, or Bcl-6 suggests a poor prognosis in primary central nervous system diffuse large B-cell lymphoma among immunocompetent individuals. (12562237)
2003
43
Role of intravitreal methotrexate in the management of primary central nervous system lymphoma with ocular involvement. (12208721)
2002
44
AIDS-related primary central nervous system lymphoma: prolonged remission associated with highly active antiretroviral therapy. (12188396)
2002
45
Telomerase activity in central nervous system malignant lymphoma. (10491533)
1999
46
Primary malignant lymphoma of the central nervous system by Ga-67 and TI-201 brain SPECT. (1464174)
1992
47
Adult lymphoblastic lymphoma: high incidence of central nervous system relapse in patients treated with the Stanford University protocol. (1286046)
1992
48
Malignant angioendotheliomatosis (intravascular lymphomatosis) clinically simulating primary angiitis of the central nervous system. (1301018)
1992
49
Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement. (3760899)
1986
50
Lymphomatoid granulomatosis involving the central nervous system: radiologic-pathologic correlation. (107755)
1979

Genetic Variations for Central Nervous System Lymphoma

Expression for genes affiliated with Central Nervous System Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Central Nervous System Lymphoma

Search GEO for disease gene expression data for Central Nervous System Lymphoma.

Pathways for genes affiliated with Central Nervous System Lymphoma

Sources:
54Reactome, 12EMD Millipore, 4Cell Signaling Technology, 52QIAGEN, 30KEGG
See all sources

Pathways related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4MYD88, IRF7
2
Hide members
10.4MYD88, IRF7
310.3BCL6, DAPK1, MGMT
410.3IRF7, MYD88, BCL10
5
Hide members
10.3TIMP3, TNFRSF13C, MYD88, BCL10
6
Apoptosis and survival Lymphotoxin-beta receptor signaling
Hide members
10.3CCL19, CCL21, CXCL13
7
Hide members
10.2CXCL13, CXCR5, CCL21, CCL19
810.2CCL19, CCL21, CXCR5, CXCL13
9
Hide members
10.2CXCL13, TNFRSF13C, CCL21, CCL19, TIMP3
1010.2CCL19, CCL21, TNFRSF13C, MYD88, BCL10
11
Hide members
10.2TIMP3, CCL19, CCL21, TNFRSF13C, MYD88, CXCL13
1210.2BCL10, BCL6, PAX5, MYD88, PRDM1, PIM1
13
Hide members
10.1CCL19, CCL21, TNFRSF13C, PIM1, CXCR5, CXCL13

Compounds for genes affiliated with Central Nervous System Lymphoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1rantes4510.6IRF7, CXCR5
2peg-104510.6CXCL13, CXCR5, CCL19
3o6-methylguanine4510.5DAPK1, MGMT, TIMP3
4teck4510.5CXCL13, CCL21, CCL19
5mip-3beta4510.5CCL19, CCL21
6cytidine45 11 2412.4BCL6, PAX5, PRDM1
7larc4510.4CCL21, CCL19
8serine4510.3IRF7, PIM1, PRDX4, DAPK1, BCL10
912-o-tetradecanoylphorbol 13-acetate4510.3TIMP3, IRF7, MGMT, BCL6
10calcium45 50 11 2413.2TIMP3, CCL19, CCL21, TNFRSF13C, MGMT, PIM1
11oligonucleotide4510.2TIMP3, IRF7, MGMT, MYD88, PAX5
12sodium bisulfite4510.1DAPK1, MGMT

GO Terms for genes affiliated with Central Nervous System Lymphoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycoprotein biosynthetic processGO:01056010.7CCL21, CCL19
2immunological synapse formationGO:00177110.6CCL19, CCL21
3establishment of T cell polarityGO:00176810.6CCL21, CCL19
4negative regulation of leukocyte apoptotic processGO:200010710.6CCL21, CCL19
5response to prostaglandin E stimulusGO:03469510.6CCL19, CCL21
6positive regulation of dendritic cell antigen processing and presentationGO:00260610.6CCL21, CCL19
7germinal center formationGO:00246710.6BCL6, CXCL13
8positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.6BCL10, MYD88, CCL21, CCL19
9positive regulation of cell motilityGO:200014710.5CCL19, CCL21
10T cell costimulationGO:03129510.5CCL19, CCL21, TNFRSF13C
11immune responseGO:00695510.5CCL19, CCL21, IGHM, CXCR5, CXCL13
12positive regulation of chemotaxisGO:05092110.5CCL19, CCL21
13immunoglobulin mediated immune responseGO:01606410.5BCL10, IRF7
14lymph node developmentGO:04853510.4CXCR5, CXCL13
15positive regulation of receptor-mediated endocytosisGO:04826010.4CCL19, CCL21
16positive regulation of neutrophil chemotaxisGO:09002310.4CCL21, CCL19
17dendritic cell chemotaxisGO:00240710.3CCL21, CCL19
18toll-like receptor signaling pathwayGO:00222410.0BCL10, MYD88, IRF7

Molecular functions related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.3CXCL13, CCL21, CCL19
2CCR7 chemokine receptor bindingGO:03173210.3CCL21, CCL19
3CCR10 chemokine receptor bindingGO:03173510.1CXCL13, CCL19

Products for genes affiliated with Central Nervous System Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Nervous System Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet