MCID: CNT005
MIFTS: 53

Central Nervous System Lymphoma malady

Cancer diseases, Neuronal diseases, Immune diseases, Rare diseases, Blood diseases categories
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Summaries for Central Nervous System Lymphoma

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Disease Ontology:8 A hematologic cancer that has material basis in lymphoma located in central nervous system.

MalaCards based summary: Central Nervous System Lymphoma, also known as primary central nervous system lymphoma, is related to macroglobulinemia and central nervous system lymphoma, primary. An important gene associated with Central Nervous System Lymphoma is IGHM (immunoglobulin heavy constant mu), and among its related pathways is Selected targets of p53. The compounds sodium bisulfite and 5-methylcytosine have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, b cells and brain, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Central Nervous System Lymphoma

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Central Nervous System Lymphoma, Aliases & Descriptions:

Name: Central Nervous System Lymphoma 8 10 62
Primary Central Nervous System Lymphoma 62
 
Primary Cns Lymphoma 8
Microglioma 8


Classifications:



External Ids:

Disease Ontology8 DOID:3234
NCIt39 C9301
ICD9CM27 200.5

Related Diseases for Central Nervous System Lymphoma

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Diseases in the Central Nervous System Lymphoma family:

Central Nervous System Lymphoma, Primary

Diseases related to Central Nervous System Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1macroglobulinemia31.0PAX5
2central nervous system lymphoma, primary30.6MGMT, IGHM, TIMP3, PAX5, DAPK1
3chronic lymphocytic leukemia30.5PAX5, IGHM
4hepatitis c30.5IRF7, TIMP3
5follicular lymphoma30.4PAX5, TNFRSF13C, IGHM
6hodgkin's lymphoma30.4PAX5, IGHM, PRDM1
7glioblastoma30.0MGMT, CHI3L1, TIMP3
8leukemia29.9PRDM1, MGMT, DAPK1, PAX5
9rheumatoid arthritis29.9TNFRSF13C, CHI3L1, TIMP3, IGHM
10b-cell lymphomas29.7TNFRSF13C, MGMT, IGHM, PRDM1, PAX5, DAPK1
11intraocular lymphoma10.5
12meningitis10.5
13multiple sclerosis10.5
14endotheliitis10.5
15acquired immunodeficiency syndrome10.4
16encephalitis10.4
17retinitis10.4
18lymphomatous meningitis10.4
19diffuse large b-cell lymphoma10.3
20hepatitis10.3
21richter's syndrome10.3
22panhypopituitarism10.3
23neurofibromatosis10.3
24cerebritis10.3
25lupus nephritis10.3
26nephritis10.3
27macroglobulinemia, waldenstrom, somatic10.3PAX5, IGHM
28gastritis10.3TIMP3, MGMT
29pilocytic astrocytoma10.3MGMT, TIMP3
30cholangiocarcinoma10.2DAPK1, TIMP3
31arthritis10.2
32common variable immunodeficiency10.2
33hematopoietic stem cell transplantation10.2
34hepatitis b10.2
35hiv-110.2
36myasthenia gravis10.2
37non-hodgkin lymphoma10.2
38renal cell carcinoma10.2
39testicular lymphoma10.2
40autoimmune thyroiditis10.2
41klinefelter's syndrome10.2
42bardet-biedl syndrome10.2
43pituitary apoplexy10.2
44progressive multifocal leukoencephalopathy10.2
45polycystic kidney disease10.2
46posterior scleritis10.2
47cerebral lymphoma10.2
48central retinal artery occlusion10.2
49diabetes insipidus10.2
50lyme disease10.2

Graphical network of the top 20 diseases related to Central Nervous System Lymphoma:



Diseases related to central nervous system lymphoma

Symptoms for Central Nervous System Lymphoma

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Drugs & Therapeutics for Central Nervous System Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Central Nervous System Lymphoma

Search NIH Clinical Center for Central Nervous System Lymphoma

Genetic Tests for Central Nervous System Lymphoma

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Anatomical Context for Central Nervous System Lymphoma

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MalaCards organs/tissues related to Central Nervous System Lymphoma:

32
B cells, Brain, Endothelial, T cells, Kidney, Liver, Pituitary, Bone marrow, Bone, Lymph node, Spinal cord, Thyroid, Breast, Tonsil, Monocytes, Nk cells, Occipital lobe, Hypothalamus

FMA organs/tissues related to Central Nervous System Lymphoma:

14
Central nervous system

Animal Models for Central Nervous System Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Central Nervous System Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.7PRDM1, TIMP3, IGHM, MGMT
2MP:00053678.5DAPK1, IGHM, TIMP3, PRDM1
3MP:00053847.5DAPK1, IGHM, TIMP3, PAX5, CHI3L1, PRDM1
4MP:00053767.3DAPK1, MGMT, IGHM, TNFRSF13C, TIMP3, IRF7
5MP:00053977.1PRDM1, IGHM, TNFRSF13C, TIMP3, PAX5, IRF7
6MP:00053877.0IGHM, TNFRSF13C, TIMP3, PAX5, IRF7, CHI3L1

Publications for Central Nervous System Lymphoma

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Articles related to Central Nervous System Lymphoma:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Central nervous system lymphoma: patterns of incidence in Indian population and effect of steroids on stereotactic biopsy yield. (25033875)
2014
2
Mechanisms of intracerebral lymphoma growth delineated in a syngeneic mouse model of central nervous system lymphoma. (23481709)
2013
3
Primary central nervous system lymphoma in immunocompetent individuals: a single center experience. (23696924)
2013
4
Is there a role for radiotherapy in the primary management of primary central nervous system lymphoma? A single-centre case series. (23688624)
2013
5
Recent advances in treatment of primary central nervous system lymphoma. (23934511)
2013
6
Utility of flow cytometry of cerebrospinal fluid as a screening tool in the diagnosis of central nervous system lymphoma. (24168498)
2013
7
Advantages of dose-dense methotrexate protocol for primary central nervous system lymphoma: comparison of two different protocols at a single institution. (24162244)
2013
8
Primary central nervous system lymphoma and meningioma in DOTATATE PET/CT. (24152642)
2013
9
Interleukin-8 in the pathogenesis of primary central nervous system lymphoma in association with HIV infection. (22664113)
2012
10
Relapse pattern and prognostic factors for patients with primary central nervous system lymphoma. (22479279)
2012
11
Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma. (22563813)
2012
12
Low frequency of blood group A in secondary central nervous system lymphoma. (23050209)
2012
13
Primary central nervous system lymphoma masquerading as bilateral vitreous floaters. (22498134)
2012
14
Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma. (23099805)
2012
15
Central nervous system lymphoma: characteristic findings on traditional and advanced imaging. (20616176)
2011
16
Survival among patients with primary central nervous system lymphoma, 1973-2004. (20556477)
2011
17
Primary central nervous system lymphoma in acquired immune deficiency syndrome mimicking toxoplasmosis. (21210240)
2011
18
Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells. (20872671)
2010
19
Somatic mutations altering Tyr641 of EZH2 are rare in primary central nervous system lymphoma. (20858097)
2010
20
Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma. (19494841)
2009
21
Insights into the biology of primary central nervous system lymphoma. (19080745)
2009
22
Preferential expression of truncated isoforms of FOXP1 in primary central nervous system lymphoma. (19680146)
2009
23
Primary central nervous system lymphoma mimicking pituitary apoplexy: case report. (18205050)
2009
24
Ocular central nervous system lymphoma mimicking choroidal neovascularization. (18435341)
2008
25
Testicular relapse of primary central nervous system lymphoma. (17487747)
2007
26
Cognitive functions in primary central nervous system lymphoma: literature review and assessment guidelines. (17284616)
2007
27
Central nervous system lymphoma in a patient with Sjogren's syndrome and autoimmune thyroiditis (Hashimoto's thyroiditis). (16941199)
2007
28
Salvage therapy for primary central nervous system lymphoma with (90)Y-Ibritumomab and Temozolomide. (17245621)
2007
29
Increasing incidence and continued dismal outcome of primary central nervous system lymphoma in Norway 1989-2003 : time trends in a 15-year national survey. (17721992)
2007
30
Delayed [(18)F]FDG PET imaging of central nervous system lymphoma: is PET better than MRI? (16850335)
2006
31
High-dose methotrexate toxicity in elderly patients with primary central nervous system lymphoma. (15653703)
2005
32
Primary Central Nervous System Lymphoma (PCNSL) occurring in pregnancy. (16003500)
2005
33
Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. (16335585)
2005
34
Severe complications after intrathecal methotrexate (MTX) for treatment of primary central nervous system lymphoma (PCNSL). (15003295)
2004
35
Selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles. (12963969)
2003
36
Treatment of primary central nervous system lymphoma in the elderly. (14765387)
2003
37
Long-term remission of primary central nervous system lymphoma by intensified methotrexate chemotherapy. (12814260)
2003
38
Intravitreal methotrexate injections for intraocular involvement in primary central nervous system lymphoma. (14740803)
2003
39
High 123I-IMP retention on SPECT image in primary central nervous system lymphoma. (12675320)
2003
40
Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. (12393412)
2003
41
Role of intravitreal methotrexate in the management of primary central nervous system lymphoma with ocular involvement. (12208721)
2002
42
Diagnostic advances and new trends for the treatment of primary central nervous system lymphoma. (12091059)
2002
43
Association of total dose intensity of chemotherapy in primary central nervous system lymphoma (human non-acquired immunodeficiency syndrome) and survival. (11334269)
2001
44
Concomitant progressive multifocal leucoencephalopathy and primary central nervous system lymphoma expressing JC virus oncogenic protein, large T antigen. (11577180)
2001
45
Strong correlation between imaging response and survival among patients with primary central nervous system lymphoma: a secondary analysis of RTOG studies 83-15 and 88-06. (10802352)
2000
46
Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type. (10668897)
2000
47
Preclinical primary central nervous system lymphoma. (9101110)
1997
48
A clinicopathological study of 21 cases of primary central nervous system lymphoma]. (8090264)
1994
49
Klinefelter's syndrome and primary central nervous system lymphoma. (2184340)
1990
50
Primary central nervous system lymphoma as a variant of Richter's syndrome in two patients with chronic lymphocytic leukemia. (2766225)
1989

Variations for Central Nervous System Lymphoma

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Expression for genes affiliated with Central Nervous System Lymphoma

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Expression patterns in normal tissues for genes affiliated with Central Nervous System Lymphoma

Search GEO for disease gene expression data for Central Nervous System Lymphoma.

Pathways for genes affiliated with Central Nervous System Lymphoma

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Pathways related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MGMT, DAPK1

Compounds for genes affiliated with Central Nervous System Lymphoma

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Compounds related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1sodium bisulfite449.9MGMT, DAPK1
25-methylcytosine44 2410.9DAPK1, MGMT
3crcs449.8MGMT, DAPK1
4cytosine44 2410.6MGMT, PAX5
5o6-methylguanine449.6DAPK1, MGMT, TIMP3
65-aza-2deoxycytidine449.5TIMP3, MGMT, DAPK1
72-methoxyestradiol44 61 2411.5PRDM1, PAX5
8methionine449.5DAPK1, MGMT, TIMP3
9cytidine44 24 1111.4PAX5, PRDM1
10deoxyribonucleic acid449.4MGMT, TIMP3
1112-o-tetradecanoylphorbol 13-acetate449.4TIMP3, IRF7, MGMT
12paraffin449.4TIMP3, PAX5, MGMT
13oligonucleotide449.0MGMT, IRF7, PAX5, TIMP3
14estrogen448.6TIMP3, MGMT, CHI3L1, DAPK1
15calcium44 50 24 1111.5MGMT, DAPK1, PAX5, TNFRSF13C, TIMP3

GO Terms for genes affiliated with Central Nervous System Lymphoma

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Biological processes related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:0001229.0PRDM1, IRF7, PAX5

Molecular functions related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1methyltransferase activityGO:0081689.4PRDM1, MGMT

Products for genes affiliated with Central Nervous System Lymphoma

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  • Antibodies
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Sources for Central Nervous System Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet