MCID: CNT005
MIFTS: 52

Central Nervous System Lymphoma malady

Neuronal diseases, Cancer diseases, Immune diseases, Rare diseases, Blood diseases categories
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Summaries for Central Nervous System Lymphoma

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A hematologic cancer that has material basis in lymphoma located in central nervous system.

MalaCards: Central Nervous System Lymphoma, also known as primary central nervous system lymphoma, is related to central nervous system lymphoma, primary and macroglobulinemia. An important gene associated with Central Nervous System Lymphoma is IGHM (immunoglobulin heavy constant mu), and among its related pathways is Selected targets of p53. The compounds sodium bisulfite and 5-methylcytosine have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, b cells and brain, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Central Nervous System Lymphoma

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8Disease Ontology, 10DISEASES, 62UMLS, 40NCIt, 58SNOMED-CT, 27ICD9CM
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Classifications:



Aliases & Descriptions:

central nervous system lymphoma 8 10 62
primary central nervous system lymphoma 62
primary cns lymphoma 8
microglioma 8


External Ids:

Disease Ontology8 DOID:3234
NCIt40 C9301
ICD9CM27 200.5

Related Diseases for Central Nervous System Lymphoma

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17GeneCards, 18GeneDecks
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Diseases in the Central Nervous System Lymphoma family:

Central Nervous System Lymphoma, Primary

Diseases related to Central Nervous System Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1central nervous system lymphoma, primary30.8MGMT, IGHM, TIMP3, PAX5, DAPK1
2macroglobulinemia30.4PAX5
3hepatitis c30.3IRF7, TIMP3
4follicular lymphoma30.3PAX5, TNFRSF13C, IGHM
5chronic lymphocytic leukemia30.3PAX5, IGHM, TNFRSF13C
6b-cell lymphomas30.3TNFRSF13C, MGMT, IGHM, PRDM1, PAX5, DAPK1
7hodgkin's lymphoma30.3PAX5, IGHM, PRDM1
8leukemia30.2PRDM1, MGMT, DAPK1, PAX5
9rheumatoid arthritis30.2TNFRSF13C, CHI3L1, TIMP3, IGHM
10intraocular lymphoma10.5
11meningitis10.5
12multiple sclerosis10.5
13endotheliitis10.5
14encephalitis10.4
15retinitis10.4
16lymphomatous meningitis10.4
17neurofibromatosis10.3
18richter's syndrome10.3
19panhypopituitarism10.3
20acquired immunodeficiency syndrome10.3
21cerebritis10.3
22diffuse large b-cell lymphoma10.3
23hepatitis10.3
24lupus nephritis10.3
25nephritis10.3
26klinefelter's syndrome10.2
27bardet-biedl syndrome10.2
28autoimmune thyroiditis10.2
29pituitary apoplexy10.2
30diabetes insipidus10.2
31lyme disease10.2
32progressive multifocal leukoencephalopathy10.2
33hepatitis b10.2
34kaposi's sarcoma10.2
35polycystic kidney disease10.2
36tonsillitis10.2
37retinal vasculitis10.2
38choroiditis10.2
39posterior scleritis10.2
40sjogren's syndrome10.2
41cerebral lymphoma10.2
42common variable immunodeficiency10.2
43wegener's granulomatosis10.2
44pancytopenia10.2
45central retinal artery occlusion10.2
46arthritis10.2
47breast cancer10.2
48central nervous system disease10.2
49herpes simplex10.2
50histoplasmosis10.2

Graphical network of the top 20 diseases related to Central Nervous System Lymphoma:



Diseases related to central nervous system lymphoma

Symptoms for Central Nervous System Lymphoma

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Drugs & Therapeutics for Central Nervous System Lymphoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Central Nervous System Lymphoma

Search NIH Clinical Center for Central Nervous System Lymphoma

Genetic Tests for Central Nervous System Lymphoma

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Anatomical Context for Central Nervous System Lymphoma

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Central Nervous System Lymphoma:

33
B cells, Brain, Endothelial, T cells, Liver, Kidney, Pituitary, Occipital lobe, Hypothalamus, Nk cells, Monocytes, Tonsil, Breast, Thyroid, Spinal cord, Lymph node, Bone, Bone marrow

FMA organs/tissues related to Central Nervous System Lymphoma:

14
Central nervous system

Animal Models for Central Nervous System Lymphoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Central Nervous System Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.7PRDM1, TIMP3, IGHM, MGMT
2MP:00053678.5DAPK1, IGHM, TIMP3, PRDM1
3MP:00053847.5DAPK1, IGHM, TIMP3, PAX5, CHI3L1, PRDM1
4MP:00053767.3DAPK1, MGMT, IGHM, TNFRSF13C, TIMP3, IRF7
5MP:00053977.1PRDM1, IGHM, TNFRSF13C, TIMP3, PAX5, IRF7
6MP:00053877.0IGHM, TNFRSF13C, TIMP3, PAX5, IRF7, CHI3L1

Publications for Central Nervous System Lymphoma

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52PubMed
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Articles related to Central Nervous System Lymphoma:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Mechanisms of intracerebral lymphoma growth delineated in a syngeneic mouse model of central nervous system lymphoma. (23481709)
2013
2
Primary central nervous system lymphoma in immunocompetent individuals: a single center experience. (23696924)
2013
3
Is there a role for radiotherapy in the primary management of primary central nervous system lymphoma? A single-centre case series. (23688624)
2013
4
Recent advances in treatment of primary central nervous system lymphoma. (23934511)
2013
5
Utility of flow cytometry of cerebrospinal fluid as a screening tool in the diagnosis of central nervous system lymphoma. (24168498)
2013
6
Advantages of dose-dense methotrexate protocol for primary central nervous system lymphoma: comparison of two different protocols at a single institution. (24162244)
2013
7
Primary central nervous system lymphoma and meningioma in DOTATATE PET/CT. (24152642)
2013
8
Interleukin-8 in the pathogenesis of primary central nervous system lymphoma in association with HIV infection. (22664113)
2012
9
Relapse pattern and prognostic factors for patients with primary central nervous system lymphoma. (22479279)
2012
10
Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma. (22563813)
2012
11
Low frequency of blood group A in secondary central nervous system lymphoma. (23050209)
2012
12
Primary central nervous system lymphoma masquerading as bilateral vitreous floaters. (22498134)
2012
13
MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma. (22729947)
2012
14
Primary central nervous system lymphoma: implication of high-dose chemotherapy followed by auto-SCT. (22002486)
2012
15
Central nervous system lymphoma: characteristic findings on traditional and advanced imaging. (20616176)
2011
16
Survival among patients with primary central nervous system lymphoma, 1973-2004. (20556477)
2011
17
Primary central nervous system lymphoma in acquired immune deficiency syndrome mimicking toxoplasmosis. (21210240)
2011
18
Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells. (20872671)
2010
19
Somatic mutations altering Tyr641 of EZH2 are rare in primary central nervous system lymphoma. (20858097)
2010
20
Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma. (19494841)
2009
21
Insights into the biology of primary central nervous system lymphoma. (19080745)
2009
22
Preferential expression of truncated isoforms of FOXP1 in primary central nervous system lymphoma. (19680146)
2009
23
Primary central nervous system lymphoma mimicking pituitary apoplexy: case report. (18205050)
2009
24
Ocular central nervous system lymphoma mimicking choroidal neovascularization. (18435341)
2008
25
Testicular relapse of primary central nervous system lymphoma. (17487747)
2007
26
Cognitive functions in primary central nervous system lymphoma: literature review and assessment guidelines. (17284616)
2007
27
Central nervous system lymphoma in a patient with Sjogren's syndrome and autoimmune thyroiditis (Hashimoto's thyroiditis). (16941199)
2007
28
Salvage therapy for primary central nervous system lymphoma with (90)Y-Ibritumomab and Temozolomide. (17245621)
2007
29
Increasing incidence and continued dismal outcome of primary central nervous system lymphoma in Norway 1989-2003 : time trends in a 15-year national survey. (17721992)
2007
30
Delayed [(18)F]FDG PET imaging of central nervous system lymphoma: is PET better than MRI? (16850335)
2006
31
High-dose methotrexate toxicity in elderly patients with primary central nervous system lymphoma. (15653703)
2005
32
Primary Central Nervous System Lymphoma (PCNSL) occurring in pregnancy. (16003500)
2005
33
Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. (16335585)
2005
34
Severe complications after intrathecal methotrexate (MTX) for treatment of primary central nervous system lymphoma (PCNSL). (15003295)
2004
35
Selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles. (12963969)
2003
36
Treatment of primary central nervous system lymphoma in the elderly. (14765387)
2003
37
Long-term remission of primary central nervous system lymphoma by intensified methotrexate chemotherapy. (12814260)
2003
38
Intravitreal methotrexate injections for intraocular involvement in primary central nervous system lymphoma. (14740803)
2003
39
High 123I-IMP retention on SPECT image in primary central nervous system lymphoma. (12675320)
2003
40
Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. (12393412)
2003
41
Role of intravitreal methotrexate in the management of primary central nervous system lymphoma with ocular involvement. (12208721)
2002
42
Diagnostic advances and new trends for the treatment of primary central nervous system lymphoma. (12091059)
2002
43
Association of total dose intensity of chemotherapy in primary central nervous system lymphoma (human non-acquired immunodeficiency syndrome) and survival. (11334269)
2001
44
Concomitant progressive multifocal leucoencephalopathy and primary central nervous system lymphoma expressing JC virus oncogenic protein, large T antigen. (11577180)
2001
45
Strong correlation between imaging response and survival among patients with primary central nervous system lymphoma: a secondary analysis of RTOG studies 83-15 and 88-06. (10802352)
2000
46
Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type. (10668897)
2000
47
Preclinical primary central nervous system lymphoma. (9101110)
1997
48
A clinicopathological study of 21 cases of primary central nervous system lymphoma]. (8090264)
1994
49
Klinefelter's syndrome and primary central nervous system lymphoma. (2184340)
1990
50
Primary central nervous system lymphoma as a variant of Richter's syndrome in two patients with chronic lymphocytic leukemia. (2766225)
1989

Variations for Central Nervous System Lymphoma

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Expression for genes affiliated with Central Nervous System Lymphoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Lymphoma

Search GEO for disease gene expression data for Central Nervous System Lymphoma.

Pathways for genes affiliated with Central Nervous System Lymphoma

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50PathCards, 12EMD Millipore
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Pathways related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MGMT, DAPK1

Compounds for genes affiliated with Central Nervous System Lymphoma

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45Novoseek, 24HMDB, 61Tocris Bioscience, 11DrugBank, 51PharmGKB
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Compounds related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1sodium bisulfite459.9MGMT, DAPK1
25-methylcytosine45 2410.9MGMT, DAPK1
3crcs459.8DAPK1, MGMT
4cytosine45 2410.6PAX5, MGMT
5o6-methylguanine459.6TIMP3, MGMT, DAPK1
65-aza-2deoxycytidine459.5DAPK1, MGMT, TIMP3
72-methoxyestradiol45 61 2411.5PRDM1, PAX5
8methionine459.5TIMP3, MGMT, DAPK1
9cytidine45 24 1111.4PRDM1, PAX5
10deoxyribonucleic acid459.4TIMP3, MGMT
1112-o-tetradecanoylphorbol 13-acetate459.4MGMT, TIMP3, IRF7
12paraffin459.4MGMT, TIMP3, PAX5
13oligonucleotide459.0MGMT, TIMP3, PAX5, IRF7
14estrogen458.6CHI3L1, TIMP3, MGMT, DAPK1
15calcium45 51 24 1111.5DAPK1, MGMT, TNFRSF13C, TIMP3, PAX5

GO Terms for genes affiliated with Central Nervous System Lymphoma

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16Gene Ontology
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Biological processes related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:0001229.0PRDM1, IRF7, PAX5

Molecular functions related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1methyltransferase activityGO:0081689.4PRDM1, MGMT

Products for genes affiliated with Central Nervous System Lymphoma

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  • Antibodies
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Sources for Central Nervous System Lymphoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet