MCID: CNT005
MIFTS: 56

Central Nervous System Lymphoma malady

Neuronal diseases, Immune diseases categories

Summaries for Central Nervous System Lymphoma

About this section
Sources:
8Disease Ontology, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A hematologic cancer that has material basis in lymphoma located in central nervous system.

MalaCards: Central Nervous System Lymphoma, also known as primary central nervous system lymphoma, is related to intraocular lymphoma and central nervous system lymphoma, primary. An important gene associated with Central Nervous System Lymphoma is IGHM (immunoglobulin heavy constant mu), and among its related pathways are DEx/H-box helicases activate type I IFN and inflammatory cytokines production and IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation. The compounds rantes and peg-10 have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, b cells and t cells, and related mouse phenotypes are endocrine/exocrine gland and no phenotypic analysis.

Aliases & Classifications for Central Nervous System Lymphoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Immune diseases


Aliases & Descriptions:

central nervous system lymphoma 8 10 60
primary central nervous system lymphoma 60
primary cns lymphoma 8
microglioma 8


External Ids:

Disease Ontology8 DOID:3234
NCIt39 C9301
ICD9CM27 200.5

Related Diseases for Central Nervous System Lymphoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Central Nervous System Lymphoma family:

Central Nervous System Lymphoma, Primary

Diseases related to Central Nervous System Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1intraocular lymphoma31.0CXCR5
2central nervous system lymphoma, primary30.8TIMP3, MGMT, PIM1, IGHM, CXCR5, CXCL13
3multiple sclerosis30.6TIMP3, CCL21, TNFRSF13C, CXCR5, CXCL13
4arthritis30.2TIMP3
5gastric lymphoma30.2BCL10, BCL6
6hepatitis b30.2IGHM, MYD88
7rheumatoid arthritis30.2TIMP3, TNFRSF13C, IGHM, CXCR5
8macroglobulinemia30.2PAX5
9hodgkin's lymphoma30.2PRDM1, IGHM, PAX5, BCL6
10herpes simplex30.2IRF7
11chronic lymphocytic leukemia30.2CCL19, TNFRSF13C, IGHM, CXCR5, PAX5, BCL6
12breast cancer30.2TIMP3, CCL21, PRDX4, BCL6, SDC1
13sjogren's syndrome30.2CXCL13, CCL21
14leukemia30.2MGMT, PIM1, PRDX4, PRDM1, CXCR5, DAPK1
15hepatitis c30.2TIMP3, IRF7, BCL6
16central nervous system cancer10.6
17central nervous system disease10.6
18nervous system cancer10.6
19nervous system disease10.6
20diffuse large b-cell lymphoma10.6
21adult lymphoma10.5
22meningitis10.5
23testicular lymphoma10.4
24cerebral lymphoma10.4
25encephalitis10.4
26retinitis10.4
27neurofibromatosis10.3
28richter's syndrome10.3
29cerebritis10.3
30panhypopituitarism10.3
31liver lymphoma10.3
32acquired immunodeficiency syndrome10.3
33hepatitis a10.3
34hepatitis10.3
35central retinal artery occlusion10.1
36autoimmune thyroiditis10.1
37bardet-biedl syndrome10.1
38klinefelter's syndrome10.1
39choroiditis10.1
40posterior scleritis10.1
41thyroid lymphoma10.1
42common variable immunodeficiency10.1
43wegener's granulomatosis10.1
44pancytopenia10.1
45pituitary apoplexy10.1
46diabetes insipidus10.1
47bone lymphoma10.1
48central nervous system leukemia10.1
49lyme disease10.1
50progressive multifocal leukoencephalopathy10.1

Graphical network of the top 20 diseases related to Central Nervous System Lymphoma:



Diseases related to central nervous system lymphoma

Clinical Features for Central Nervous System Lymphoma

About this section

Drugs & Therapeutics for Central Nervous System Lymphoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Central Nervous System Lymphoma

Drug clinical trials:

Search ClinicalTrials for Central Nervous System Lymphoma

Search NIH Clinical Center for Central Nervous System Lymphoma

Search CenterWatch for Central Nervous System Lymphoma

Genetic Tests for Central Nervous System Lymphoma

About this section

Anatomical Context for Central Nervous System Lymphoma

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Central Nervous System Lymphoma:

32
B cells, T cells, Brain, Endothelial, Liver, Spinal cord, Kidney, Breast, Pituitary, Tonsil, Nk cells, Hypothalamus, Bone, Monocytes, Testis, Thyroid, Bone marrow, Lymph node, Occipital lobe

FMA organs/tissues related to Central Nervous System Lymphoma:

14
Central nervous system

Animal Models for Central Nervous System Lymphoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Central Nervous System Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.3PRDM1, PRDX4, MGMT
2MP:00030129.8MGMT, PIM1, PRDX4, PRDM1, IGHM, MYD88
3MP:00053879.8SDC1, TIMP3, CCL19, TNFRSF13C, IRF7, PIM1
4MP:00053849.8IGHM, PRDM1, PRDX4, PIM1, TNFRSF13C, TIMP3
5MP:00053979.8TIMP3, CCL19, TNFRSF13C, PIM1, PRDM1, IGHM

Publications for Central Nervous System Lymphoma

About this section
Sources:
50PubMed
See all sources

Articles related to Central Nervous System Lymphoma:

(show top 50)    (show all 654)
idTitleAuthorsYear
1
Primary central nervous system Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly: a clinicopathologic study of five cases. (24399201)
2014
2
Diffusely infiltrating central nervous system lymphoma involving the brainstem in an immune-competent patient. (24217110)
2014
3
Mechanisms of intracerebral lymphoma growth delineated in a syngeneic mouse model of central nervous system lymphoma. (23481709)
2013
4
Prognostic significance of the aggregative perivascular growth pattern of tumor cells in primary central nervous system diffuse large B-cell lymphoma. (23482670)
2013
5
The Cleveland Clinic Experience With Primary Central Nervous System Lymphoma. (23608829)
2013
6
Primary central nervous system ALK positive anaplastic large cell lymphoma with predominantly leptomeningeal involvement in an adult. (23549832)
2013
7
Atypical presentation of primary central nervous system non-Hodgkin lymphoma in immunocompetent young adults. (22885166)
2013
8
A rare presentation of hypertrophic olivary degeneration secondary to primary central nervous system lymphoma. (23857254)
2013
9
Central nervous system lymphoma initially diagnosed as tumefactive multiple sclerosis after brain biopsy. (23411706)
2013
10
Is there still a need for specific central nervous system directed prophylaxis for diffuse large B-cell lymphoma in the rituximab era? (23906017)
2013
11
Intravitreal injection of anti-VEGF and diagnosis of primary intraocular central nervous system lymphoma. (23306179)
2013
12
Refining the predictors of risk for central nervous system involvement in patients with mantle cell lymphoma. (23432685)
2013
13
Role of chemotherapy additional to high-dose methotrexate for primary central nervous system lymphoma (PCNSL). (23152274)
2012
14
Salvage treatment with temozolomide in refractory or relapsed primary central nervous system lymphoma and assessment of the MGMT status. (21720808)
2012
15
Natalizumab-associated central nervous system lymphoma?--another patient. (22383229)
2012
16
First case report of a peripheral T-cell lymphoma, not otherwise specified, of the central nervous system in a child. (22367391)
2012
17
Prognosis of primary central nervous system lymphoma treated with radiotherapy alone. (22961611)
2012
18
Elevated LDH and paranasal sinus involvement are risk factors for central nervous system involvement in patients with peripheral T-cell lymphoma. (21220520)
2011
19
Use of rituximab in combination with high-dose methotrexate in the treatment of primary central nervous system lymphoma in a mycophenolate mofetil treated patient with lupus nephritis. (20670084)
2011
20
An unusual case of primary anaplastic large cell central nervous system lymphoma: an 8-year success story. (22707580)
2011
21
Imaging of primary central nervous system lymphoma. (21513925)
2011
22
Late relapse in primary central nervous system lymphoma: clonal persistence. (21372070)
2011
23
Clinical characteristics and outcome of isolated extracerebral relapses of primary central nervous system lymphoma: a case series. (21381074)
2011
24
Increasing age at diagnosis and worsening renal function in patients with primary central nervous system lymphoma. (21103909)
2011
25
Imaging in primary central nervous system lymphoma. (24148721)
2010
26
Primary central nervous system lymphoma in the elderly: a multicentre retrospective analysis. (20738305)
2010
27
Management of patients with primary central nervous system lymphoma treated with high-dose methotrexate. (19349264)
2009
28
Differential gene expression in central nervous system lymphoma. (19122120)
2009
29
Racial differences in primary central nervous system lymphoma incidence and survival rates. (19273630)
2009
30
Incidence and radiographic findings of primary central nervous system lymphoma in immunocompetent patients in southern Thailand. (18705395)
2008
31
Calculated versus measured creatinine clearance for dosing methotrexate in the treatment of primary central nervous system lymphoma. (16972068)
2007
32
Primary central nervous system lymphoma. (17590348)
2007
33
Patterns of treatment in older adults with primary central nervous system lymphoma. (17647247)
2007
34
An update on therapy of primary central nervous system lymphoma. (17124077)
2006
35
Surgical interventions for primary central nervous system lymphoma. (17134115)
2006
36
Antiviral and immunomodulatory treatment for AIDS-related primary central nervous system lymphoma: AIDS Malignancies Consortium pilot study 019. (16640817)
2006
37
Relapse of primary central nervous system lymphoma: clinical features, outcome and prognostic factors. (16699873)
2006
38
Primary Central Nervous System Lymphoma (PCNSL) occurring in pregnancy. (16003500)
2005
39
Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma. (15690135)
2005
40
Primary central nervous system lymphoma in a renal transplant recipient with Bardet-Biedl syndrome. (16387110)
2005
41
Pituitary stalk thickening and primary central nervous system lymphoma. (15072472)
2004
42
Very late central nervous system relapse in a patient with B cell lymphoblastic lymphoma. (15564734)
2004
43
Selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles. (12963969)
2003
44
Long-term remission of primary central nervous system lymphoma by intensified methotrexate chemotherapy. (12814260)
2003
45
Panhypopituitarism as an initial manifestation of primary central nervous system non-Hodgkin's lymphoma. (14561574)
2003
46
Diagnostic advances and new trends for the treatment of primary central nervous system lymphoma. (12091059)
2002
47
AIDS-related primary central nervous system lymphoma: prolonged remission associated with highly active antiretroviral therapy. (12188396)
2002
48
Therapeutic management of primary central nervous system lymphoma: lessons from prospective trials. (11038028)
2000
49
Primary central nervous system lymphoma in Japan: a nationwide survey. (10760418)
1999
50
Prognosis of primary malignant lymphoma of the central nervous system--a retrospective study of 32 cases. (1280339)
1992

Genetic Variations for Central Nervous System Lymphoma

About this section

Expression for genes affiliated with Central Nervous System Lymphoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Central Nervous System Lymphoma

Search GEO for disease gene expression data for Central Nervous System Lymphoma.

Pathways for genes affiliated with Central Nervous System Lymphoma

About this section
Sources:
53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 29KEGG
See all sources

Pathways related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4MYD88, IRF7
2
Hide members
10.4MYD88, IRF7
310.3BCL6, DAPK1, MGMT
410.3IRF7, MYD88, BCL10
5
Hide members
10.3TIMP3, TNFRSF13C, MYD88, BCL10
6
Apoptosis and survival Lymphotoxin-beta receptor signaling
Hide members
10.3CCL19, CCL21, CXCL13
7
Hide members
10.2CXCL13, CXCR5, CCL21, CCL19
810.2CCL19, CCL21, CXCR5, CXCL13
9
Hide members
10.2CXCL13, TNFRSF13C, CCL21, CCL19, TIMP3
1010.2CCL19, CCL21, TNFRSF13C, MYD88, BCL10
11
Hide members
10.2TIMP3, CCL19, CCL21, TNFRSF13C, MYD88, CXCL13
1210.2BCL10, BCL6, PAX5, MYD88, PRDM1, PIM1
13
Hide members
10.1CCL19, CCL21, TNFRSF13C, PIM1, CXCR5, CXCL13

Compounds for genes affiliated with Central Nervous System Lymphoma

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1rantes4410.6IRF7, CXCR5
2peg-104410.6CXCL13, CXCR5, CCL19
3o6-methylguanine4410.5DAPK1, MGMT, TIMP3
4teck4410.5CXCL13, CCL21, CCL19
5mip-3beta4410.5CCL19, CCL21
6cytidine44 11 2412.4BCL6, PAX5, PRDM1
7larc4410.4CCL21, CCL19
8serine4410.3IRF7, PIM1, PRDX4, DAPK1, BCL10
912-o-tetradecanoylphorbol 13-acetate4410.3TIMP3, IRF7, MGMT, BCL6
10calcium44 49 11 2413.2TIMP3, CCL19, CCL21, TNFRSF13C, MGMT, PIM1
11oligonucleotide4410.2TIMP3, IRF7, MGMT, MYD88, PAX5
12sodium bisulfite4410.1DAPK1, MGMT

GO Terms for genes affiliated with Central Nervous System Lymphoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycoprotein biosynthetic processGO:01056010.7CCL21, CCL19
2immunological synapse formationGO:00177110.6CCL19, CCL21
3establishment of T cell polarityGO:00176810.6CCL21, CCL19
4negative regulation of leukocyte apoptotic processGO:200010710.6CCL21, CCL19
5response to prostaglandin E stimulusGO:03469510.6CCL19, CCL21
6positive regulation of dendritic cell antigen processing and presentationGO:00260610.6CCL21, CCL19
7germinal center formationGO:00246710.6BCL6, CXCL13
8positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.6BCL10, MYD88, CCL21, CCL19
9positive regulation of cell motilityGO:200014710.5CCL19, CCL21
10T cell costimulationGO:03129510.5CCL19, CCL21, TNFRSF13C
11immune responseGO:00695510.5CCL19, CCL21, IGHM, CXCR5, CXCL13
12positive regulation of chemotaxisGO:05092110.5CCL19, CCL21
13immunoglobulin mediated immune responseGO:01606410.5BCL10, IRF7
14lymph node developmentGO:04853510.4CXCR5, CXCL13
15positive regulation of receptor-mediated endocytosisGO:04826010.4CCL19, CCL21
16positive regulation of neutrophil chemotaxisGO:09002310.4CCL21, CCL19
17dendritic cell chemotaxisGO:00240710.3CCL21, CCL19
18toll-like receptor signaling pathwayGO:00222410.0BCL10, MYD88, IRF7

Molecular functions related to Central Nervous System Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.3CXCL13, CCL21, CCL19
2CCR7 chemokine receptor bindingGO:03173210.3CCL21, CCL19
3CCR10 chemokine receptor bindingGO:03173510.1CXCL13, CCL19

Products for genes affiliated with Central Nervous System Lymphoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Nervous System Lymphoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet