MCID: CNT007
MIFTS: 48

Central Nervous System Tuberculosis malady

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Tuberculosis

Aliases & Descriptions for Central Nervous System Tuberculosis:

Name: Central Nervous System Tuberculosis 12 14
Intracranial Tuberculoma 12 69
Tuberculosis of Meninges and Central Nervous System 12
Tuberculosis, Central Nervous System 69
Tuberculous Abscess of Brain 12
Tuberculoma, Intracranial 42
Tuberculoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1638
ICD9CM 35 013.2 013.20
MeSH 42 D016862
SNOMED-CT 64 40769007 416265003
UMLS 69 C0085388

Summaries for Central Nervous System Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tuberculomas located in brain or located in spinal cord.

MalaCards based summary : Central Nervous System Tuberculosis, also known as intracranial tuberculoma, is related to tuberculosis and central nervous system germ cell tumor. An important gene associated with Central Nervous System Tuberculosis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related phenotypes are immune system and hematopoietic system

Related Diseases for Central Nervous System Tuberculosis

Diseases related to Central Nervous System Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 30.8 CD4 CD8A IL1B
2 central nervous system germ cell tumor 10.3 CD163 CD207
3 toxic optic neuropathy 10.2 IL1B MMP9
4 polyneuropathy in collagen vascular disease 10.2 CD163 FASLG MMP9
5 midline interhemispheric variant of holoprosencephaly 10.2 FAS FASLG
6 optic nerve neoplasm 10.2 CD163 MMP9 TIMP1
7 congenital hypomyelination neuropathy 10.2 FASLG MMP9 TIMP1
8 chondrodysplasia punctata, rhizomelic, type 1 10.2 IL1B MMP9 TIMP1
9 chordoid meningioma 10.1 IL1B MMP9 TIMP1
10 skeletal muscle cancer 10.1 FAS FASLG
11 retinal drusen 10.1 ELANE MMP9 TIMP1
12 renal oncocytoma 10.1 ELANE MMP9 TIMP1
13 skin conditions 10.1 FAS FASLG IL1B
14 baritosis 10.1 FAS FASLG IL1B
15 nervous system cancer 10.1 IL1B MMP9 TIMP1
16 alcoholic pancreatitis 10.1 CD4 CD8A
17 orbital disease 10.1 CD4 CD8A
18 mixed ductal-endocrine carcinoma 10.1 ELANE MMP9 TIMP1
19 infancy electroclinical syndrome 10.1 ELANE IL1B MMP9
20 stenosis of lacrimal sac 10.1 ELANE IL1B MMP9
21 pneumoconiosis due to talc 10.1 CD4 FAS
22 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 10.0 ELANE MMP9 TIMP1
23 colloid adenoma 10.0 CD4 CD8A
24 complex regional pain syndrome 10.0 CXCL10 IL1B MMP9
25 retinal microaneurysm 10.0 CD4 CD8A
26 scrotum melanoma 10.0 CD4 CD8A
27 hypoparathyroidism-retardation-dysmorphism syndrome 10.0 CD4 GJB6 IL1B
28 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.0 CD4 GJB6 IL1B
29 cervix melanoma 10.0 CD4 CD8A
30 appendix carcinoid tumor 10.0 MMP9 MUC5AC TIMP1
31 lambda 5 deficiency 10.0 CD4 CD8A STAT1
32 lumbar spinal canal and spinal cord meningioma 10.0 CD207 CD4 CD8A
33 histiocytosis 10.0 ELANE IL1B MMP9 TIMP1
34 newcastle disease 10.0 CD4 CD8A FAS
35 intratubular embryonal carcinoma 10.0 ELANE IL1B MMP9 TIMP1
36 dysplastic nevus syndrome 9.9 CD4 CD8A CXCL10
37 pseudo-meigs syndrome 9.9 FAS FASLG MUC5AC
38 motor peripheral neuropathy 9.9 CD4 CD8A STAT1
39 human immunodeficiency virus infectious disease 9.9 CD4 CD8A IL1B
40 cerebrum cancer 9.9 CD4 CD8A IL1B
41 eczema herpeticum 9.9 CD4 CD8A
42 autoimmune polyendocrine syndrome type 1 9.9 CD4 CD8A MMP9 TIMP1
43 dysentery 9.9 CD4 CD8A ELANE
44 coronin-1a deficiency 9.9 CD4 CD8A
45 advanced sleep phase syndrome, familial, 1 9.9 CD4 CXCL10 IL1B MMP9
46 exophthalmos 9.9 CD4 CXCL10 IL1B STAT1
47 acquired immunodeficiency syndrome 9.9
48 acute dacryoadenitis 9.8 CD4 CD8A ELANE
49 psoriasis susceptibility 1 9.8 CD4 CD8A FAS FASLG
50 cholera 9.8 CD4 ELANE IL1B TIMP1

Graphical network of the top 20 diseases related to Central Nervous System Tuberculosis:



Diseases related to Central Nervous System Tuberculosis

Symptoms & Phenotypes for Central Nervous System Tuberculosis

MGI Mouse Phenotypes related to Central Nervous System Tuberculosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.31 ANXA5 ARG1 CD163 CD207 CD4 CD8A
2 hematopoietic system MP:0005397 10.3 ARG1 CD163 CD207 CD4 CD8A CXCL10
3 homeostasis/metabolism MP:0005376 10.28 ARG1 CD163 CD4 CXCL10 ELANE FAS
4 cardiovascular system MP:0005385 10.13 CD163 CXCL10 FAS FASLG GJB6 IL1B
5 mortality/aging MP:0010768 10.1 FAS FASLG IL1B MMP9 POU3F3 STAT1
6 integument MP:0010771 9.97 CD4 CD8A FAS FASLG GJB6 IL1B
7 nervous system MP:0003631 9.9 CD4 CD8A CXCL10 FAS FASLG GJB6
8 neoplasm MP:0002006 9.8 FAS FASLG IL1B MMP9 STAT1 TIMP1
9 normal MP:0002873 9.56 FAS FASLG STAT1 ANXA5 ARG1 CD4
10 skeleton MP:0005390 9.23 ANXA5 FAS FASLG IL1B MMP9 POU3F3

Drugs & Therapeutics for Central Nervous System Tuberculosis

Drugs for Central Nervous System Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 185)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
4
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
5
Rifapentine Approved Phase 4,Phase 1 61379-65-5 6323497
6
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
7
Isoniazid Approved Phase 4,Phase 1,Phase 2 54-85-3 3767
8
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
9
Methadone Approved Phase 4 76-99-3 4095
10 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Autonomic Agents Phase 4,Phase 2,Phase 3
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Anti-Asthmatic Agents Phase 4,Phase 3
14 Bromides Phase 4
15 Bronchodilator Agents Phase 4,Phase 3
16 Cholinergic Agents Phase 4
17 Cholinergic Antagonists Phase 4
18 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Parasympatholytics Phase 4
20 Respiratory System Agents Phase 4,Phase 3
21 Tiotropium Bromide Phase 4 136310-93-5
22 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
23 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
24 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
25 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
26 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
27 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
29 Antiemetics Phase 4,Phase 2,Phase 3
30 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
31 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
32 glucocorticoids Phase 4,Phase 2,Phase 3
33 Hormone Antagonists Phase 4,Phase 2,Phase 3
34 Hormones Phase 4,Phase 2,Phase 3
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
36 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
37 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
38 Neuroprotective Agents Phase 4,Phase 3,Phase 2
39 Prednisolone acetate Phase 4,Phase 3,Phase 2
40 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
41 Prednisolone phosphate Phase 4,Phase 3,Phase 2
42 Protective Agents Phase 4,Phase 3,Phase 2
43 Adrenergic Agents Phase 4,Phase 3
44 Adrenergic Agonists Phase 4,Phase 3
45 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 3
46 Adrenergic beta-Agonists Phase 4,Phase 3
47 Anti-Allergic Agents Phase 4
48 Dermatologic Agents Phase 4,Phase 2
49
Fluticasone Phase 4 90566-53-3, 80474-14-2 62924 22833648
50 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4

Interventional clinical trials:

(show all 45)
id Name Status NCT ID Phase
1 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4
2 Clinical Outcomes of Tiotropium Plus Fluticasone Propionate/Salmeterol Compared With Tiotropium for Chronic Obstructive Pulmonary Disease (COPD) in Korea Completed NCT00864812 Phase 4
3 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Not yet recruiting NCT02588196 Phase 4
4 Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings Not yet recruiting NCT03089983 Phase 4
5 Benign Acute Pericarditis: Brief Versus Longer Treatment Using Aspirin Terminated NCT00946907 Phase 4
6 TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial Unknown status NCT02060006 Phase 3
7 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
8 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3
9 A Trial on Clinical Efficacy of 1% Versus 2% Lignocaine in Cough Suppression and Pain Relief in Patients Undergoing Flexible Bronchoscopy Completed NCT01955824 Phase 2, Phase 3
10 Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy Completed NCT00294658 Phase 3
11 A Safety Study of Intravenous Pro-Netupitant and Palonosetron Combination for the Prevention of Nausea and Vomiting Completed NCT02517021 Phase 3
12 Effects of Adalimumab in Mucopolysaccharidosis Types I, II and VI Recruiting NCT02437253 Phase 2, Phase 3
13 Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Not yet recruiting NCT03100786 Phase 3
14 Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Not yet recruiting NCT03092817 Phase 3
15 A Study in Patients With Chronic Obstructive Pulmonary Disease (FAIR) Terminated NCT01351792 Phase 3
16 Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) Treatment Trial Withdrawn NCT01442428 Phase 2, Phase 3
17 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3
18 Metronidazole for Pulmonary Tuberculosis (South Korea) Completed NCT00425113 Phase 2
19 A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis Completed NCT02237365 Phase 2
20 Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Completed NCT01802502 Phase 2
21 Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study Completed NCT01158755 Phase 2
22 Augmentation of Psychotherapy With D-Cycloserine in Agoraphobia Completed NCT01928823 Phase 2
23 Infliximab (Remicade ) to Treat Dermatomyositis and Polymyositis Completed NCT00033891 Phase 2
24 Progression of HIV-Disease Under Low Dose Corticosteroids Completed NCT01299948 Phase 2
25 Safety and Efficacy of Palonosetron in Preventing Chemotherapy-induced Nausea and Vomiting Completed NCT00503386 Phase 2
26 Optimizing Treatment to Improve TBM Outcomes in Children Recruiting NCT02958709 Phase 1, Phase 2
27 Pilot Study to Estimate the Potential Efficacy and Safety of Using Adjunctive Ibuprofen for the Treatment of XDR Tuberculosis Enrolling by invitation NCT02781909 Phase 2
28 Interaction of Buprenorphine With HIV Medications and Tuberculosis Medications Completed NCT00877591 Phase 1
29 Evaluation of the Pharmacokinetic Interaction Between PA-824 and Midazolam Completed NCT01768273 Phase 1
30 Pharmacokinetics, Safety and Tolerability of Escalating Rifapentine Doses in Healthy Volunteers Completed NCT01162486 Phase 1
31 Therapeutic Vaccination and Immune Modulation - New Treatment Strategies for the MDR Tuberculosis Pandemic Recruiting NCT02503839 Phase 1
32 Cycloserine in the Treatment of Sleep Apnea Terminated NCT02735694 Phase 1
33 Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Unknown status NCT00433719
34 Local Anesthesia and Tuberculin Skin Test in Infants and Children Unknown status NCT00309673
35 Association of Multiple Genetic Polymorphisms With Clozapine-Associated Metabolic Change in Schizophrenia Unknown status NCT00717509
36 Tiotropium in Patients With Tuberculosis (TB) Destroyed Lung Unknown status NCT01365702
37 Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone Completed NCT01317654
38 Rijavithi Viral and Mycobacterium PCR Arrays in CNS Infection Study Completed NCT00807378
39 Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF Completed NCT01371916
40 Effectiveness of Alcohol Interventions Among Tuberculosis (TB) Patients in Tomsk Oblast, Russia Completed NCT00675961
41 Levofloxacin in Bacterial Rhinosinussitis Completed NCT02712502
42 The Impact of Alcohol Consumption on Tuberculosis Treatment Outcomes Recruiting NCT02840877
43 Comparative Study of Nonintubated Uniport Thoracoscopic Surgery Using Thoracic Paravertebral Nerve Block Versus Intercostal Nerve Block for Peripheral Solitary Pulmonary Nodule Patients Recruiting NCT03086213
44 E-Nose: Diagnostic Tool for Pleural TB Active, not recruiting NCT02765087
45 A Prospective Household Observational Cohort Study of Influenza, Respiratory Syncytial Virus and Other Respiratory Pathogens Community Burden and Transmission Dynamics in South Africa Not yet recruiting NCT02519803

Search NIH Clinical Center for Central Nervous System Tuberculosis

Cochrane evidence based reviews: tuberculoma, intracranial

Genetic Tests for Central Nervous System Tuberculosis

Anatomical Context for Central Nervous System Tuberculosis

MalaCards organs/tissues related to Central Nervous System Tuberculosis:

39
Brain, Spinal Cord, T Cells, Monocytes, Lymph Node

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Tuberculosis:

18
Brain Or

Publications for Central Nervous System Tuberculosis

Articles related to Central Nervous System Tuberculosis:

(show top 50) (show all 78)
id Title Authors Year
1
Central Nervous System Tuberculosis in an Immigrant Child. ( 27231208 )
2016
2
Tuberculous ventriculitis: A rare complication of central nervous system tuberculosis. ( 27242238 )
2016
3
Risk Factors for Central Nervous System Tuberculosis. ( 26438712 )
2015
4
Immune reconstitution inflammatory syndrome in central nervous system tuberculosis. ( 27451593 )
2015
5
Central nervous system tuberculosis reviewed. ( 26338350 )
2015
6
Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis. ( 26041993 )
2015
7
Central nervous system tuberculosis: an imaging-focused review of a reemerging disease. ( 25653877 )
2015
8
Immunoconfirmation of central nervous system tuberculosis by blotting: A study of 300 cases. ( 26972880 )
2015
9
Central nervous system tuberculosis. ( 24887691 )
2014
10
A rare case of central nervous system tuberculosis. ( 25478256 )
2014
11
HIV-associated central nervous system tuberculosis. ( 24715493 )
2014
12
Central nervous system tuberculosis. ( 25241567 )
2014
13
Characteristics of central nervous system tuberculosis in a low-incidence country: a series of 20 cases and a review of the literature. ( 24451103 )
2014
14
Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications. ( 24623792 )
2014
15
Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study. ( 25048551 )
2014
16
Central Nervous System Tuberculosis: Challenges and Advances in Diagnosis and Treatment. ( 24122343 )
2013
17
The dual face of central nervous system tuberculosis: a new Janus Bifrons? ( 23305698 )
2013
18
Central nervous system tuberculosis presenting as branch retinal vein occlusion. ( 22738141 )
2013
19
Central nervous system tuberculosis: a disease from Papua New Guinea in North Queensland. ( 23480051 )
2013
20
Central nervous system tuberculosis: mimicking neuropsychiatric systemic lupus erythematosus. ( 22367698 )
2012
21
The PCR-Based Diagnosis of Central Nervous System Tuberculosis: Up to Date. ( 22666577 )
2012
22
Multi-drug-resistant central nervous system tuberculosis. ( 22626692 )
2012
23
Central nervous system tuberculosis: a forgotten diagnosis. ( 22735252 )
2012
24
Role of Mycobacterium tuberculosis pknD in the pathogenesis of central nervous system tuberculosis. ( 22243650 )
2012
25
A life-threatening central nervous system-tuberculosis inflammatory reaction nonresponsive to corticosteroids and successfully controlled by infliximab in a young patient with a variant of juvenile idiopathic arthritis. ( 22647865 )
2012
26
Central nervous system tuberculosis: pathophysiology and imaging findings. ( 23122262 )
2012
27
Central nervous system tuberculosis in non-HIV-positive children: a single-center, 6 year experience. ( 22095412 )
2012
28
The many faces of central nervous system tuberculosis. ( 21825249 )
2011
29
Central nervous system tuberculosis. ( 22032500 )
2011
30
Central nervous system tuberculosis. ( 21572867 )
2011
31
Central nervous system tuberculosis masquerading as primary dementia: a case report. ( 22127948 )
2011
32
Lymphocyte apoptosis in children with central nervous system tuberculosis: a case control study. ( 22111973 )
2011
33
Hypopituitarism as unusual sequelae to central nervous system tuberculosis. ( 22029037 )
2011
34
Treatment of central nervous system tuberculosis infections and neurological complications of tuberculosis treatment. ( 21834764 )
2011
35
Ophthalmic manifestations of central nervous system tuberculosis--two case reports. ( 22533169 )
2011
36
Ventriculitis caused by Aspergillus fumigatus in a child with central nervous system tuberculosis. ( 20701684 )
2011
37
Management of central nervous system tuberculosis in children: light and shade. ( 21222370 )
2010
38
Central nervous system tuberculosis. ( 20944756 )
2010
39
Central nervous system tuberculosis and adjuvant corticosteroid therapy. ( 19182749 )
2009
40
Magnetic resonance imaging in central nervous system tuberculosis. ( 19881100 )
2009
41
Pathogenesis of central nervous system tuberculosis. ( 19275620 )
2009
42
Central nervous system tuberculosis subsequent to dural grafting. ( 18973080 )
2008
43
Central nervous system tuberculosis: pathogenesis and clinical aspects. ( 18400795 )
2008
44
Diagnostic challenges of central nervous system tuberculosis. ( 18760024 )
2008
45
Unusual central nervous system tuberculosis debut in children: stroke. ( 18259759 )
2008
46
Improved diagnosis of central nervous system tuberculosis by MPB64-Target PCR. ( 24031203 )
2008
47
Diagnosis of central nervous system tuberculosis by T-cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells. ( 18632925 )
2008
48
Mortality associated with central nervous system tuberculosis. ( 17920686 )
2007
49
IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis. ( 17158965 )
2007
50
Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo. ( 17202385 )
2007

Variations for Central Nervous System Tuberculosis

Expression for Central Nervous System Tuberculosis

Search GEO for disease gene expression data for Central Nervous System Tuberculosis.

Pathways for Central Nervous System Tuberculosis

Pathways related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 ARG1 CD207 CD4 CD8A CXCL10 ELANE
2
Show member pathways
13.3 CD4 CXCL10 FAS FASLG IL1B STAT1
3
Show member pathways
13.23 CD4 CXCL10 FASLG IL1B MMP9 STAT1
4
Show member pathways
12.78 CXCL10 FAS FASLG IL1B MMP9 STAT1
5
Show member pathways
12.77 CD4 CXCL10 FAS FASLG STAT1
6
Show member pathways
12.67 CXCL10 FAS FASLG IL1B STAT1
7
Show member pathways
12.65 CD4 CD8A FAS FASLG IL1B STAT1
8
Show member pathways
12.53 CD4 FAS FASLG IL1B STAT1
9
Show member pathways
12.48 CD4 IL1B STAT1 TIMP1
10
Show member pathways
12.32 CD4 CD8A FAS IL1B
11 12.23 CD8A CXCL10 FAS FASLG IL1B STAT1
12
Show member pathways
12.2 CXCL10 IL1B MMP9 MUC5AC
13
Show member pathways
11.94 CXCL10 FAS FASLG IL1B STAT1
14 11.89 CD163 CD4 CD8A
15 11.86 ARG1 CXCL10 IL1B MMP9
16
Show member pathways
11.84 CD4 IL1B STAT1
17
Show member pathways
11.82 CD4 IL1B STAT1
18
Show member pathways
11.8 ELANE MMP9 TIMP1
19 11.79 CD4 CD8A IL1B
20 11.74 CXCL10 FAS IL1B MMP9
21 11.68 CD4 CD8A IL1B
22 11.65 CD4 MMP9 STAT1
23 11.61 FASLG IL1B MMP9 STAT1 TIMP1
24 11.53 IL1B MMP9 TIMP1
25 11.41 CXCL10 IL1B TIMP1
26
Show member pathways
11.41 CD4 CD8A FASLG IL1B STAT1
27 11.25 CXCL10 IL1B STAT1
28 11.21 FAS FASLG IL1B
29 10.94 IL1B MMP9 TIMP1
30 10.93 STAT1 TIMP1
31 10.9 CD163 CD207 CD4 CD8A IL1B

GO Terms for Central Nervous System Tuberculosis

Cellular components related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 ANXA5 ARG1 ELANE FAS FASLG IL1B
2 extracellular space GO:0005615 9.76 ARG1 CXCL10 ELANE FASLG IL1B MMP9
3 extracellular region GO:0005576 9.73 ANXA5 ARG1 CD163 CD8A CXCL10 ELANE
4 cell surface GO:0009986 9.65 CD4 CD8A ELANE FAS FASLG
5 T cell receptor complex GO:0042101 9.37 CD4 CD8A
6 external side of plasma membrane GO:0009897 9.17 ANXA5 CD163 CD4 CD8A CXCL10 FAS

Biological processes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 ANXA5 FAS MMP9 POU3F3 TIMP1
2 extracellular matrix disassembly GO:0022617 9.65 ELANE MMP9 TIMP1
3 defense response to virus GO:0051607 9.62 CD207 CD8A CXCL10 STAT1
4 negative regulation of angiogenesis GO:0016525 9.61 CXCL10 FASLG STAT1
5 positive regulation of protein phosphorylation GO:0001934 9.56 CD4 FAS IL1B MMP9
6 response to vitamin D GO:0033280 9.55 CD4 CXCL10
7 positive regulation of calcium-mediated signaling GO:0050850 9.54 CD4 CD8A
8 response to peptide hormone GO:0043434 9.54 ARG1 STAT1 TIMP1
9 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.52 FAS FASLG
10 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.51 FAS FASLG
11 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.49 CD4 IL1B
12 immune response GO:0006955 9.43 CD4 CD8A CXCL10 FAS FASLG IL1B
13 necroptotic signaling pathway GO:0097527 9.4 FAS FASLG
14 response to lipopolysaccharide GO:0032496 9.17 ARG1 CXCL10 ELANE FAS FASLG GJB6
15 inflammatory cell apoptotic process GO:0006925 9.16 FAS FASLG

Molecular functions related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL10 FASLG IL1B TIMP1

Sources for Central Nervous System Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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