MCID: CNT007
MIFTS: 46

Central Nervous System Tuberculosis

Categories: Neuronal diseases, Infectious diseases

Aliases & Classifications for Central Nervous System Tuberculosis

MalaCards integrated aliases for Central Nervous System Tuberculosis:

Name: Central Nervous System Tuberculosis 12 14
Intracranial Tuberculoma 12 69
Tuberculosis of Meninges and Central Nervous System 12
Tuberculosis, Central Nervous System 69
Tuberculous Abscess of Brain 12
Tuberculoma, Intracranial 41
Tuberculoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1638
ICD9CM 34 013.2 013.20
MeSH 41 D016862
SNOMED-CT 64 40769007 416265003

Summaries for Central Nervous System Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tuberculomas located in brain or located in spinal cord.

MalaCards based summary : Central Nervous System Tuberculosis, also known as intracranial tuberculoma, is related to systemic lupus erythematosus and mycobacterium tuberculosis 1. An important gene associated with Central Nervous System Tuberculosis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Influenza A and Pathways in cancer. Affiliated tissues include brain or, brain and spinal cord, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Central Nervous System Tuberculosis

Diseases related to Central Nervous System Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 27.1 CXCL10 ELANE FAS FASLG IL1B SELE
2 mycobacterium tuberculosis 1 10.7
3 cavernous sinus meningioma 10.5 CD163 CD207
4 necrobiosis lipoidica 10.4 CD163 GLI1
5 squamous cell carcinoma of the hypopharynx 10.3 MMP9 TIMP1
6 keratocystic odontogenic tumor 10.3 GLI1 MMP9 SHH
7 histiocytic and dendritic cell cancer 10.3 CD163 CD207
8 type ii mixed cryoglobulinemia 10.2 FAS FASLG
9 photokeratitis 10.2 CD163 FASLG MMP9
10 lymphocytic gastritis 10.2 FAS FASLG
11 mid-dermal elastolysis 10.2 ELANE TIMP1
12 chronic venous leg ulcers 10.2 FASLG MMP9 TIMP1
13 pulmonary emphysema 10.2 ELANE MMP9 TIMP1
14 aortic aneurysm, familial abdominal, 1 10.1 ELANE MMP9 TIMP1
15 conjunctival nevus 10.1 MMP9 MUC5AC TIMP1
16 chronic follicular conjunctivitis 10.1 IL1B MMP9
17 gastric tubular adenocarcinoma 10.1 GLI1 MUC5AC SHH
18 acute myocarditis 10.1 FAS FASLG STAT1
19 pancreas adenocarcinoma 10.0 GLI1 MUC5AC SHH
20 kashin-beck disease 9.9 FAS IL1B
21 epstein-barr virus-associated gastric carcinoma 9.9 FAS FASLG MUC5AC
22 keratitis, hereditary 9.9 GJB6 IL1B MMP9
23 acquired immunodeficiency syndrome 9.9
24 miliary tuberculosis 9.9
25 appendicitis 9.9 IL1B MMP9 TIMP1
26 carotid artery disease 9.9 CD163 MMP9 SELE TIMP1
27 chorioamnionitis 9.8 ELANE IL1B MMP9
28 gingivitis 9.8 ELANE IL1B MMP9
29 stroke, ischemic 9.8
30 arthritis 9.8
31 retinal vein occlusion 9.8
32 dementia 9.8
33 cerebritis 9.8
34 retinitis 9.8
35 lupus erythematosus 9.8
36 hypopituitarism 9.8
37 aneurysm 9.8
38 headache 9.8
39 interstitial lung disease 9.8 IL1B MMP9 TIMP1
40 scleritis 9.7 MMP9 SELE
41 kawasaki disease 9.7 ELANE MMP9 SELE TIMP1
42 gingival disease 9.7 ELANE IL1B TIMP1
43 silicosis 9.7 FAS FASLG IL1B
44 pneumoconiosis 9.7 FAS FASLG IL1B
45 graft-versus-host disease 9.7 FAS FASLG IL1B
46 demyelinating disease 9.6 CXCL10 IL1B MMP9
47 arteries, anomalies of 9.6 IL1B MMP9 SELE
48 periodontitis 9.6 ELANE IL1B MMP9 TIMP1
49 periodontal disease 9.6 ELANE IL1B MMP9 TIMP1
50 pulmonary fibrosis 9.6 IL1B MMP9 TIMP1

Graphical network of the top 20 diseases related to Central Nervous System Tuberculosis:



Diseases related to Central Nervous System Tuberculosis

Symptoms & Phenotypes for Central Nervous System Tuberculosis

MGI Mouse Phenotypes related to Central Nervous System Tuberculosis:

43 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.37 TIMP1 SHH STAT1 ELANE FAS ARG1
2 immune system MP:0005387 10.35 TIMP1 SHH STAT1 ELANE FAS ARG1
3 cardiovascular system MP:0005385 10.29 SHH TIMP1 STAT1 FAS CD163 CXCL10
4 hematopoietic system MP:0005397 10.29 TIMP1 STAT1 ELANE ARG1 FAS CD163
5 cellular MP:0005384 10.28 SHH STAT1 FASLG FAS CD163 CXCL10
6 mortality/aging MP:0010768 10.22 SHH TIMP1 STAT1 ELANE ARG1 FAS
7 digestive/alimentary MP:0005381 10.07 STAT1 SHH FASLG FAS MMP9 MUC5AC
8 integument MP:0010771 10.06 SELE SHH STAT1 FASLG FAS IL1B
9 nervous system MP:0003631 10.06 SHH STAT1 FASLG ARG1 FAS CXCL10
10 neoplasm MP:0002006 10.02 TIMP1 SHH STAT1 ELANE FAS FASLG
11 limbs/digits/tail MP:0005371 9.98 SHH TIMP1 STAT1 FAS MMP9 GLI1
12 normal MP:0002873 9.86 STAT1 SELE SHH ELANE ARG1 FAS
13 respiratory system MP:0005388 9.76 SHH TIMP1 FAS CD163 FASLG SELE
14 skeleton MP:0005390 9.61 TIMP1 SHH STAT1 FASLG FAS MMP9
15 vision/eye MP:0005391 9.23 SHH STAT1 SELE FASLG FAS CD163

Drugs & Therapeutics for Central Nervous System Tuberculosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3

Search NIH Clinical Center for Central Nervous System Tuberculosis

Cochrane evidence based reviews: tuberculoma, intracranial

Genetic Tests for Central Nervous System Tuberculosis

Anatomical Context for Central Nervous System Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Tuberculosis:

18
Brain Or

MalaCards organs/tissues related to Central Nervous System Tuberculosis:

38
Brain, Spinal Cord, Testes, T Cells, Monocytes, Myeloid, Lymph Node

Publications for Central Nervous System Tuberculosis

Articles related to Central Nervous System Tuberculosis:

(show top 50) (show all 89)
# Title Authors Year
1
Surface-modified gatifloxacin nanoparticles with potential for treating central nervous system tuberculosis. ( 28331318 )
2017
2
Factors Determining the Clinical Spectrum, Course and Response to Treatment, and Complications in Seronegative Patients with Central Nervous System Tuberculosis. ( 28479800 )
2017
3
Central Nervous System Tuberculosis. ( 28281443 )
2017
4
Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. ( 28173836 )
2017
5
Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis. ( 28280495 )
2017
6
Correction: A scoring system to effectively evaluate central nervous system tuberculosis in patients with miliary tuberculosis. ( 28767710 )
2017
7
Central Nervous System Tuberculosis: An Imaging Perspective. ( 28283299 )
2017
8
Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count. ( 28263476 )
2017
9
A scoring system to effectively evaluate central nervous system tuberculosis in patients with military tuberculosis. ( 28531173 )
2017
10
Ruptured intracranial tuberculous aneurysm, a rare complication of central nervous system tuberculosis- A report and review of literature. ( 28488632 )
2017
11
Central nervous system Tuberculosis in a man from Cambodia with worsening headaches. ( 29026544 )
2017
12
Central Nervous System Tuberculosis in an Immigrant Child. ( 27231208 )
2016
13
Tuberculous ventriculitis: A rare complication of central nervous system tuberculosis. ( 27242238 )
2016
14
Immune reconstitution inflammatory syndrome in central nervous system tuberculosis. ( 27451593 )
2015
15
Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis. ( 26041993 )
2015
16
Risk Factors for Central Nervous System Tuberculosis. ( 26438712 )
2015
17
Immunoconfirmation of central nervous system tuberculosis by blotting: A study of 300 cases. ( 26972880 )
2015
18
Central nervous system tuberculosis: an imaging-focused review of a reemerging disease. ( 25653877 )
2015
19
Central nervous system tuberculosis reviewed. ( 26338350 )
2015
20
Central nervous system tuberculosis. ( 24887691 )
2014
21
A rare case of central nervous system tuberculosis. ( 25478256 )
2014
22
Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications. ( 24623792 )
2014
23
HIV-associated central nervous system tuberculosis. ( 24715493 )
2014
24
Characteristics of central nervous system tuberculosis in a low-incidence country: a series of 20 cases and a review of the literature. ( 24451103 )
2014
25
Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study. ( 25048551 )
2014
26
Central nervous system tuberculosis. ( 25241567 )
2014
27
Central Nervous System Tuberculosis: Challenges and Advances in Diagnosis and Treatment. ( 24122343 )
2013
28
Central nervous system tuberculosis: a disease from Papua New Guinea in North Queensland. ( 23480051 )
2013
29
The dual face of central nervous system tuberculosis: a new Janus Bifrons? ( 23305698 )
2013
30
Central nervous system tuberculosis presenting as branch retinal vein occlusion. ( 22738141 )
2013
31
Role of Mycobacterium tuberculosis pknD in the pathogenesis of central nervous system tuberculosis. ( 22243650 )
2012
32
Central nervous system tuberculosis: mimicking neuropsychiatric systemic lupus erythematosus. ( 22367698 )
2012
33
A life-threatening central nervous system-tuberculosis inflammatory reaction nonresponsive to corticosteroids and successfully controlled by infliximab in a young patient with a variant of juvenile idiopathic arthritis. ( 22647865 )
2012
34
Central nervous system tuberculosis: a forgotten diagnosis. ( 22735252 )
2012
35
The PCR-Based Diagnosis of Central Nervous System Tuberculosis: Up to Date. ( 22666577 )
2012
36
Multi-drug-resistant central nervous system tuberculosis. ( 22626692 )
2012
37
Central nervous system tuberculosis in non-HIV-positive children: a single-center, 6 year experience. ( 22095412 )
2012
38
Central nervous system tuberculosis: pathophysiology and imaging findings. ( 23122262 )
2012
39
Ophthalmic manifestations of central nervous system tuberculosis--two case reports. ( 22533169 )
2011
40
Central nervous system tuberculosis masquerading as primary dementia: a case report. ( 22127948 )
2011
41
The many faces of central nervous system tuberculosis. ( 21825249 )
2011
42
Central nervous system tuberculosis. ( 22032500 )
2011
43
Treatment of central nervous system tuberculosis infections and neurological complications of tuberculosis treatment. ( 21834764 )
2011
44
Ventriculitis caused by Aspergillus fumigatus in a child with central nervous system tuberculosis. ( 20701684 )
2011
45
Central nervous system tuberculosis. ( 21572867 )
2011
46
Hypopituitarism as unusual sequelae to central nervous system tuberculosis. ( 22029037 )
2011
47
Lymphocyte apoptosis in children with central nervous system tuberculosis: a case control study. ( 22111973 )
2011
48
Management of central nervous system tuberculosis in children: light and shade. ( 21222370 )
2010
49
Central nervous system tuberculosis. ( 20944756 )
2010
50
Central nervous system tuberculosis and adjuvant corticosteroid therapy. ( 19182749 )
2009

Variations for Central Nervous System Tuberculosis

Expression for Central Nervous System Tuberculosis

Search GEO for disease gene expression data for Central Nervous System Tuberculosis.

Pathways for Central Nervous System Tuberculosis

Pathways related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 CXCL10 FAS FASLG IL1B STAT1
2 12.57 FAS FASLG GLI1 MMP9 SHH STAT1
3
Show member pathways
12.44 FAS FASLG MMP9 STAT1
4 12.41 CXCL10 FAS FASLG IL1B STAT1
5
Show member pathways
12.32 CXCL10 FAS FASLG IL1B STAT1
6
Show member pathways
12.2 CXCL10 IL1B MMP9 MUC5AC
7 12.17 FAS FASLG MMP9 SHH
8
Show member pathways
12.07 FAS FASLG IL1B STAT1
9
Show member pathways
11.87 CXCL10 FAS FASLG IL1B STAT1
10
Show member pathways
11.83 FASLG IL1B STAT1
11 11.78 ARG1 CXCL10 IL1B MMP9
12 11.77 IL1B SELE STAT1
13
Show member pathways
11.76 ELANE MMP9 TIMP1
14 11.62 CD163 CD207 IL1B
15 11.61 FASLG IL1B MMP9 STAT1 TIMP1
16 11.52 IL1B MMP9 TIMP1
17
Show member pathways
11.51 IL1B MMP9 SELE
18 11.39 CXCL10 FAS IL1B MMP9 SELE
19 11.38 CXCL10 IL1B TIMP1
20 11.24 ELANE MMP9 SELE
21 11.2 CXCL10 IL1B STAT1
22 10.9 IL1B MMP9 TIMP1
23 10.89 STAT1 TIMP1
24 10.47 FAS FASLG IL1B SELE

GO Terms for Central Nervous System Tuberculosis

Cellular components related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ARG1 CD163 CXCL10 ELANE FAS FASLG
2 cell surface GO:0009986 9.65 ELANE FAS FASLG SCUBE2 SHH
3 membrane raft GO:0045121 9.46 FAS FASLG SELE SHH
4 extracellular space GO:0005615 9.36 ARG1 CXCL10 ELANE FASLG IL1B MMP9

Biological processes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 GLI1 IL1B POU3F3 SHH STAT1
2 negative regulation of apoptotic process GO:0043066 9.93 FAS MMP9 POU3F3 SHH TIMP1
3 cell-cell signaling GO:0007267 9.9 CXCL10 FASLG IL1B SHH
4 regulation of receptor activity GO:0010469 9.85 CXCL10 FASLG IL1B SHH TIMP1
5 leukocyte migration GO:0050900 9.78 ELANE IL1B MMP9 SELE
6 inflammatory response GO:0006954 9.77 CD163 CXCL10 FAS IL1B SELE
7 negative regulation of angiogenesis GO:0016525 9.74 CXCL10 FASLG STAT1
8 lung development GO:0030324 9.73 ARG1 GLI1 SHH
9 extracellular matrix disassembly GO:0022617 9.7 ELANE MMP9 TIMP1
10 apoptotic signaling pathway GO:0097190 9.69 FAS FASLG SHH
11 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.61 FAS FASLG
12 prostate gland development GO:0030850 9.58 GLI1 SHH
13 digestive tract morphogenesis GO:0048546 9.58 GLI1 SHH
14 response to peptide hormone GO:0043434 9.58 ARG1 STAT1 TIMP1
15 positive regulation of cell proliferation GO:0008284 9.56 CXCL10 FASLG GLI1 IL1B POU3F3 SHH
16 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.55 FAS FASLG
17 leukocyte migration involved in inflammatory response GO:0002523 9.49 ELANE SELE
18 necroptotic signaling pathway GO:0097527 9.43 FAS FASLG
19 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.32 GLI1 SHH
20 ventral midline development GO:0007418 9.26 GLI1 SHH
21 response to lipopolysaccharide GO:0032496 9.23 ARG1 CXCL10 ELANE FAS FASLG GJB6
22 metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136 9.16 SHH STAT1
23 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 CXCL10 GLI1 IL1B POU3F3 SHH STAT1

Molecular functions related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL10 FASLG IL1B TIMP1

Sources for Central Nervous System Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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47 NDF-RT
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54 OMIM via Orphanet
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65 SNOMED-CT via HPO
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70 UMLS via Orphanet
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