MCID: CNT046
MIFTS: 39

Central Nervous System Vasculitis malady

Cardiovascular diseases, Neuronal diseases categories
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Summaries for Central Nervous System Vasculitis

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MalaCards based summary: Central Nervous System Vasculitis, also known as vasculitis, central nervous system, is related to vasculitis and cerebritis. An important gene associated with Central Nervous System Vasculitis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Integrated Pancreatic Cancer Pathway and RNA Polymerase I Promoter Opening. The compounds aebsf and ndga have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are muscle and no phenotypic analysis.

Aliases & Classifications for Central Nervous System Vasculitis

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Central Nervous System Vasculitis, Aliases & Descriptions:

Name: Central Nervous System Vasculitis 8
 
Vasculitis, Central Nervous System 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Neuronal diseases


External Ids:

Disease Ontology8 DOID:525
MeSH34 D020293
NCIt39 C84622

Related Diseases for Central Nervous System Vasculitis

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Graphical network of the top 20 diseases related to Central Nervous System Vasculitis:



Diseases related to central nervous system vasculitis

Symptoms for Central Nervous System Vasculitis

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Drugs & Therapeutics for Central Nervous System Vasculitis

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Drug clinical trials:

Search ClinicalTrials for Central Nervous System Vasculitis

Search NIH Clinical Center for Central Nervous System Vasculitis

Genetic Tests for Central Nervous System Vasculitis

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Anatomical Context for Central Nervous System Vasculitis

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MalaCards organs/tissues related to Central Nervous System Vasculitis:

32
Brain, Spinal cord, Testes, Endothelial

Animal Models for Central Nervous System Vasculitis or affiliated genes

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MGI Mouse Phenotypes related to Central Nervous System Vasculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1APP, TNF
2MP:00030128.8APP, TNF

Publications for Central Nervous System Vasculitis

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Articles related to Central Nervous System Vasculitis:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
Varicella zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with natalizumab. (24479415)
2014
2
High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. (24722305)
2014
3
Unilateral chronic relapsing primary central nervous system vasculitis. (24528778)
2014
4
Malignant perivascular melanoma mimicking primary central nervous system vasculitis. (23263476)
2013
5
Childhood central nervous system vasculitis. (23608691)
2013
6
Central nervous system vasculitis. (23475760)
2013
7
L36. Evidence-based clinical science and art in the diagnosis of central nervous system vasculitis. (23474051)
2013
8
Childhood central nervous system vasculitis. (23622312)
2013
9
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. (23710607)
2013
10
Recent understanding on diagnosis and management of central nervous system vasculitis in children. (23008735)
2012
11
Possible central nervous system vasculitis as an early presentation of Crohn's disease. A challenge in diagnosis and management. (22964818)
2012
12
Cerebral haemorrhage in the presence of primary childhood central nervous system vasculitis--a review. (22684518)
2012
13
von Willebrand factor antigen--a possible biomarker of disease activity in childhood central nervous system vasculitis? (22740622)
2012
14
Vessel wall MRI to differentiate between reversible cerebral vasoconstriction syndrome and central nervous system vasculitis: preliminary results. (22156692)
2012
15
Rapidly progressive primary central nervous system vasculitis. (20959356)
2011
16
Primary central nervous system vasculitis presenting with intracranial hemorrhage. (22038406)
2011
17
Isolated central nervous system vasculitis associated with antiribonuclear protein antibody. (22937341)
2011
18
Central nervous system vasculitis: still more questions than answers. (22379458)
2011
19
Two uncommon manifestations of leptospirosis: Sweet's syndrome and central nervous system vasculitis. (21771425)
2011
20
Investigation of childhood central nervous system vasculitis: magnetic resonance angiography versus catheter cerebral angiography. (20132140)
2010
21
Primary central nervous system vasculitis and moyamoya disease: similarities and differences. (20037765)
2010
22
The role of imaging in the diagnosis of central nervous system vasculitis. (20425011)
2010
23
Primary central nervous system vasculitis: Is it a single disease? (21031572)
2010
24
Primary central nervous system vasculitis mimicking brain tumour: case report and literature review. (19370353)
2009
25
Angiographic diagnosis of primary central nervous system vasculitis with spinal cord involvement. (19364941)
2009
26
Refractory central nervous system vasculitis and gastrocnemius myalgia syndrome in Crohn's disease successfully treated with anti-tumor necrosis factor-alpha antibody. (18304612)
2009
27
Unusual cause of acute neurologic deficit in childhood: primary central nervous system vasculitis presenting with basilar arterial occlusion. (18690464)
2009
28
Central nervous system vasculitis. (19908043)
2009
29
Primary central nervous system vasculitis: is biopsy appropriate? (18350582)
2008
30
Brain abscess formation at the site of intracerebral hemorrhage secondary to central nervous system vasculitis. (18518742)
2008
31
Central nervous system vasculitis after starting methimazole in a woman with Graves' disease. (18788922)
2008
32
Primary central nervous system vasculitis with prominent leptomeningeal enhancement: a subset with a benign outcome. (18240248)
2008
33
Angiography-negative primary central nervous system vasculitis: a syndrome involving small cerebral vessels. (18794709)
2008
34
Efficacy of tumor necrosis factor alpha blockade in primary central nervous system vasculitis resistant to immunosuppressive treatment. (18240197)
2008
35
Central nervous system vasculitis. (12774201)
2003
36
Central nervous system vasculitis in the intensive care unit. (12418446)
2002
37
Unusual and instructive case of immune-mediated inner ear disease associated with central nervous system vasculitis. (10629494)
2000
38
Intravenous gammaglobulin in the treatment of central nervous system vasculitis associated with SjAPgren's syndrome. (10782846)
2000
39
Central nervous system vasculitis. (9642543)
1998
40
Uveitis and central nervous system vasculitis. (9517787)
1998
41
Central nervous system vasculitis in systemic lupus erythematosus: a case successfully treated with cyclophosphamide and steroids. (19078225)
1997
42
Classification and histopathologic spectrum of central nervous system vasculitis. (9367965)
1997
43
Radiographic features of central nervous system vasculitis. (9367964)
1997
44
Response of central nervous system vasculitis to irradiation. (1673534)
1991
45
Magnetic resonance imaging of central nervous system vasculitis. A case report of Henoch-SchAPnlein purpura. (2386069)
1990
46
Ephedrine-induced intracerebral hemorrhage and central nervous system vasculitis. (2237962)
1990
47
Phenylpropanolamine: an over-the-counter drug causing central nervous system vasculitis and intracerebral hemorrhage. Case report and review. (2956531)
1987
48
Central nervous system vasculitis. (3826768)
1987
49
Florid central nervous system vasculitis in a fatal case of systemic lupus erythematosus. (7175846)
1982
50
Central nervous system vasculitis in rheumatoid arthritis. (597801)
1977

Variations for Central Nervous System Vasculitis

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Expression for genes affiliated with Central Nervous System Vasculitis

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Expression patterns in normal tissues for genes affiliated with Central Nervous System Vasculitis

Search GEO for disease gene expression data for Central Nervous System Vasculitis.

Pathways for genes affiliated with Central Nervous System Vasculitis

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Pathways related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1APP, TNF
2
Show member pathways
9.1APP, TNF
3
Show member pathways
9.1APP, TNF
4
Show member pathways
Alzheimers Disease37
9.1APP, TNF
5
Show member pathways
9.1TNF, APP
6
Show member pathways
9.1APP, TNF
7
Show member pathways
9.1APP, TNF
8
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
9.1APP, TNF
9
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.1APP, TNF

Compounds for genes affiliated with Central Nervous System Vasculitis

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Compounds related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1aebsf449.5APP, TNF
2ndga449.4APP, TNF
3c2ceramide449.4APP, TNF
4chloroquine44 2 50 28 1113.4APP, TNF
5lactacystin449.4TNF, APP
6egcg449.4APP, TNF
7simvastatin44 50 61 28 24 1114.4APP, TNF
8curcumin449.4TNF, APP
9tacrolimus44 50 1111.4APP, TNF
10methotrexate50 44 1111.3TNF, APP
11butyrate449.3APP, TNF
12actinomycin d449.3APP, TNF
13cyclosporin a44 28 6111.2APP, TNF
14h2o2449.2TNF, APP
15dexamethasone44 50 28 1112.1APP, TNF
16lipid449.1APP, TNF
17vegf449.0APP, TNF
18retinoic acid44 249.8APP, TNF

GO Terms for genes affiliated with Central Nervous System Vasculitis

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Cellular components related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.1APP, TNF
2cell surfaceGO:0099868.8APP, TNF

Biological processes related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459449.1APP, TNF
2extracellular matrix organizationGO:0301988.8APP, TNF

Molecular functions related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1APP, TNF

Products for genes affiliated with Central Nervous System Vasculitis

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  • Antibodies
  • Proteins
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Sources for Central Nervous System Vasculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet