MCID: CNT046
MIFTS: 47

Central Nervous System Vasculitis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Vasculitis

MalaCards integrated aliases for Central Nervous System Vasculitis:

Name: Central Nervous System Vasculitis 12 14
Vasculitis, Central Nervous System 69

Classifications:



External Ids:

Disease Ontology 12 DOID:525
MeSH 41 D020293
NCIt 46 C84622
UMLS 69 C0751878

Summaries for Central Nervous System Vasculitis

MalaCards based summary : Central Nervous System Vasculitis, also known as vasculitis, central nervous system, is related to vasculitis and microscopic polyangiitis. An important gene associated with Central Nervous System Vasculitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Glucosamine and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and spinal cord, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Central Nervous System Vasculitis

Diseases related to Central Nervous System Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)
# Related Disease Score Top Affiliating Genes
1 vasculitis 31.4 CD40LG CRP TNF
2 microscopic polyangiitis 30.1 HLA-DRB1 TNF
3 purpura 30.0 CD40LG CRP TNF
4 relapsing polychondritis 29.9 CRP IFNG IL6
5 hematopoietic stem cell transplantation 29.6 IFNG IL6 TNF
6 cytomegalovirus infection 29.6 IFNG IL6 TNF
7 familial mediterranean fever 29.3 CRP IL1B TNF
8 uveitis 29.3 IFNG IL17A TNF
9 brucellosis 28.8 CD40LG CRP IFNG IL6 TNF
10 leptospirosis 28.5 CD40LG CRP IL1B IL6 TNF
11 crohn's disease 28.3 CRP IFNG IL1B IL6 TLR9 TNF
12 central nervous system disease 28.1 IFNG IL17A IL1B TLR9 TNF
13 meningitis 27.9 CD40LG CRP IFNG IL1B IL6 TLR9
14 toxoplasmosis 27.8 CD40LG IFNG IL1B IL6 TLR9 TNF
15 arthritis 27.6 HLA-DRB1 IFNG IL17A IL1B IL6 TNF
16 nervous system disease 27.5 CD40LG IFNG IL1B IL6 SMUG1 TLR9
17 multiple sclerosis 27.3 HLA-DRB1 IFNG IL17A IL1B IL6 TLR9
18 systemic lupus erythematosus 26.8 CD40LG CRP HLA-DRB1 IFNG IL17A IL1B
19 rheumatoid arthritis 26.8 CD40LG CRP HLA-DRB1 IFNG IL17A IL1B
20 primary angiitis of the central nervous system 11.4
21 ovarian squamous cell carcinoma 10.6 CRP SMUG1
22 aortitis 10.5 CRP SMUG1
23 cerebral lymphoma 10.5 SMUG1 TLR9
24 cold agglutinin disease 10.5 CRP IL6
25 diabetic foot ulcers 10.4 CRP IL6
26 cryopyrin-associated periodic syndrome 10.4 CRP IL6
27 neutrophilia, hereditary 10.4 CRP IL6
28 acute cholangitis 10.4 CRP IL6
29 cardiovascular syphilis 10.4 CD40LG SMUG1
30 cardiogenic shock 10.4 CRP IL6
31 acalculous cholecystitis 10.4 CD40LG CRP
32 eye lymphoma 10.4 IL6 TLR9
33 chondromalacia 10.4 SMUG1 TNFRSF10A
34 mononeuritis multiplex 10.4 CD40LG CRP
35 laryngeal tuberculosis 10.4 CDK9 SMUG1
36 spinal disease 10.4 CRP IL6
37 tolosa-hunt syndrome 10.4 CD40LG SMUG1
38 neuronitis 10.4 CD40LG TNFRSF10A
39 acute maxillary sinusitis 10.3 CD40LG CRP
40 castleman disease 10.3 CRP IL6
41 cartilage disease 10.3 CRP SMUG1 TNFRSF10A
42 anca-associated vasculitis 10.3 HLA-DRB1 IL6
43 skeletal tuberculosis 10.3 CRP SMUG1 TNFRSF10A
44 beryllium disease 10.3 HLA-DRB1 TNF
45 japanese spotted fever 10.3 CD40LG CRP
46 geniculate herpes zoster 10.3 CD40LG TNFRSF10A
47 intermittent explosive disorder 10.3 CRP IL6 SMUG1
48 berylliosis 10.3 HLA-DRB1 IFNG
49 cerebritis 10.3
50 scorpion envenomation 10.3 IL6 TNF

Graphical network of the top 20 diseases related to Central Nervous System Vasculitis:



Diseases related to Central Nervous System Vasculitis

Symptoms & Phenotypes for Central Nervous System Vasculitis

MGI Mouse Phenotypes related to Central Nervous System Vasculitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 SMUG1 CD40LG TLR9 TNF CRP IFNG
2 hematopoietic system MP:0005397 9.92 CD40LG TLR9 TNF IFNG TNFRSF10A IL17A
3 immune system MP:0005387 9.81 CD40LG TLR9 TNF CRP IFNG TNFRSF10A
4 mortality/aging MP:0010768 9.65 SMUG1 CD40LG TLR9 CDK9 TNF IFNG
5 neoplasm MP:0002006 9.1 SMUG1 TNF IFNG TNFRSF10A IL1B IL6

Drugs & Therapeutics for Central Nervous System Vasculitis

Drugs for Central Nervous System Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glucosamine Approved, Investigational, Nutraceutical 3416-24-8 439213
2 Antibodies
3 Antibodies, Antiphospholipid
4 Immunoglobulins
5 Anticoagulants
6 Antimetabolites
7 Fibrinolytic Agents
8 Glucuronyl glucosamine glycan sulfate
9 Hypoglycemic Agents
10 Hypolipidemic Agents
11 Lipid Regulating Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
2 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
3 Impact of Vasculitis on Employment and Income Completed NCT02476292
4 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
5 Vessel Wall Imaging for Diagnosis and Monitoring of Central Nervous System (CNS) Vasculitis Recruiting NCT03166319
6 Pediatric Vasculitis Initiative Recruiting NCT02006134
7 Vasculitis Pregnancy Registry Recruiting NCT02593565
8 Journey of Patients With Vasculitis From First Symptom to Diagnosis Recruiting NCT03410290
9 Magnetic Resonance Imaging of Intracranial Vasculopathies Not yet recruiting NCT03032809

Search NIH Clinical Center for Central Nervous System Vasculitis

Genetic Tests for Central Nervous System Vasculitis

Anatomical Context for Central Nervous System Vasculitis

MalaCards organs/tissues related to Central Nervous System Vasculitis:

38
Brain, Endothelial, Spinal Cord, Testes

Publications for Central Nervous System Vasculitis

Articles related to Central Nervous System Vasculitis:

(show top 50) (show all 161)
# Title Authors Year
1
Primary central nervous system vasculitis associated with lymphoma. ( 29429967 )
2018
2
Central nervous system vasculitis in a patient with HIV infection: a diagnostic challenge. ( 29236897 )
2017
3
Focal Hemispheric Central Nervous System Vasculitis: An Unusual Form Of Primary Angiitis. ( 28718271 )
2017
4
Central nervous system vasculitis presenting as an ischaemic stroke in a young woman with systemic sclerosis. ( 28977489 )
2017
5
Pitfalls of PACNS: A Rare Case of Central Nervous System Vasculitis Associated with Toxoplasmosis. ( 28765346 )
2017
6
Case report of a 28-year-old male with the rapid progression of steroid-resistant central nervous system vasculitis diagnosed by a brain biopsy. ( 28804113 )
2017
7
Central nervous system vasculitis in systemic lupus erythematosus: a case series report in a tertiary referral centre. ( 28420057 )
2017
8
Association of primary central nervous system vasculitis with the presence of specific human leucocyte antigen gene variant. ( 28734234 )
2017
9
Unihemispheric central nervous system vasculitis. ( 29260024 )
2017
10
Central nervous system vasculitis imaging: Simplified. ( 29133684 )
2017
11
Coccidioidal meningitis complicated by central nervous system vasculitis in a patient with leukemia. ( 28386527 )
2017
12
Central nervous system vasculitis in adults: An update. ( 28087351 )
2017
13
Magnetic resonance imaging in central nervous system vasculitis in a patient affected by crioglobulin-negative hepatitis C virus infection: A likely correlation. ( 28735554 )
2017
14
Adult Primary Central Nervous System Vasculitis. ( 28786262 )
2017
15
Primary Central Nervous System Vasculitis Mimicking a Cortical Brain Tumor: A Case Report. ( 28516076 )
2017
16
Successful Treatment of Central Nervous System Vasculitis Associated with Relapsing Polychondritis With Cyclophosphamide. ( 28502337 )
2017
17
Primary central nervous system vasculitis and its mimicking diseases - clinical features, outcome, comorbidities and diagnostic results - A case control study. ( 28324788 )
2017
18
Concordance of Time-of-Flight MRA and Digital Subtraction Angiography in Adult Primary Central Nervous System Vasculitis. ( 28751515 )
2017
19
Usual and Unusual Manifestations of Systemic and Central Nervous System Vasculitis. ( 27894445 )
2017
20
Central nervous system vasculitis in adults and children. ( 27112683 )
2016
21
High-Resolution Vessel Wall MRI : Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis. ( 27530660 )
2016
22
Management of primary and secondary central nervous system vasculitis. ( 26599380 )
2016
23
The Role of Catheter Angiography in the Diagnosis of Central Nervous System Vasculitis. ( 27781050 )
2016
24
A case of primary central nervous system vasculitis diagnosed by second brain biopsy and treated successfully. ( 26960271 )
2016
25
Central nervous system vasculitis in pediatric microscopic polyangiitis: A case report and review of literature. ( 27156236 )
2016
26
Isolated Central Nervous System Vasculitis as a Manifestation of Neurosarcoidosis. ( 27083067 )
2016
27
Primary Central Nervous System Vasculitis With Optic Nerve Involvement. ( 26693942 )
2016
28
354a88Diagnostic Utility of Cerebral Biopsy Following Suggestive Cerebral Angiogram in the Workup of Central Nervous System Vasculitis. ( 27399552 )
2016
29
Adult primary central nervous system vasculitis treatment and course: Analysis of 163 patients. ( 25708615 )
2015
30
Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis. ( 25425493 )
2015
31
Mycophenolate mofetil in primary central nervous system vasculitis. ( 25800827 )
2015
32
Primary central nervous system vasculitis preceded by granulomatous hypophysitis: Case report with a review of the literature. ( 26539311 )
2015
33
An update of the Mayo Clinic cohort of patients with adult primary central nervous system vasculitis: description of 163 patients. ( 26020379 )
2015
34
Catastrophic primary central nervous system vasculitis. ( 24854370 )
2014
35
Unilateral chronic relapsing primary central nervous system vasculitis. ( 24528778 )
2014
36
Varicella zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with natalizumab. ( 24479415 )
2014
37
Central Nervous System vasculitis associated with Hepatitis C virus infection: A brain MRI-supported diagnosis. ( 24211061 )
2014
38
High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. ( 24722305 )
2014
39
Late onset Leigh syndrome mimicking central nervous system vasculitis. ( 27896101 )
2014
40
Diagnosis and classification of central nervous system vasculitis. ( 24491822 )
2014
41
Crohns disease with central nervous system vasculitis causing subarachnoid hemorrhage due to aneurysm and cerebral ischemic stroke. ( 25506170 )
2014
42
Childhood central nervous system vasculitis. ( 23608691 )
2013
43
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. ( 23710607 )
2013
44
Febrile ulceronecrotic Mucha-Habermann disease with central nervous system vasculitis. ( 22276640 )
2013
45
Childhood central nervous system vasculitis. ( 23622312 )
2013
46
Malignant perivascular melanoma mimicking primary central nervous system vasculitis. ( 23263476 )
2013
47
Central nervous system vasculitis associated with linear scleroderma. ( 23466848 )
2013
48
Central nervous system vasculitis secondary to systemic sclerosis. ( 23664129 )
2013
49
Central Nervous System Vasculitis. ( 24435038 )
2013
50
Pseudotumoral presentation of primary central nervous system vasculitis. ( 23689414 )
2013

Variations for Central Nervous System Vasculitis

Expression for Central Nervous System Vasculitis

Search GEO for disease gene expression data for Central Nervous System Vasculitis.

Pathways for Central Nervous System Vasculitis

Pathways related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 CD40LG CRP HLA-DRB1 IFNG IL17A IL1B
2
Show member pathways
13.6 CD40LG IFNG IL17A IL1B IL6 TNF
3
Show member pathways
13.37 CD40LG IL17A IL1B IL6 TLR9 TNF
4
Show member pathways
13.32 CD40LG HLA-DRB1 IFNG IL17A IL1B IL6
5
Show member pathways
13.25 CD40LG IL17A IL1B IL6 TNF TNFRSF10A
6
Show member pathways
12.81 CD40LG HLA-DRB1 IFNG IL17A IL1B IL6
7
Show member pathways
12.73 HLA-DRB1 IFNG IL1B IL6 TLR9 TNF
8
Show member pathways
12.69 CD40LG IL1B IL6 TLR9 TNF
9
Show member pathways
12.68 IFNG IL1B IL6 TNF
10
Show member pathways
12.63 CD40LG IFNG IL1B TNF
11
Show member pathways
12.61 CD40LG IL1B TLR9 TNF TNFRSF10A
12
Show member pathways
12.59 CD40LG HLA-DRB1 IFNG TNF
13
Show member pathways
12.58 IFNG IL17A IL1B IL6 TNF
14
Show member pathways
12.58 HLA-DRB1 IFNG IL17A IL1B IL6 TNF
15 12.54 CD40LG IFNG IL17A IL1B TLR9 TNF
16
Show member pathways
12.53 IFNG IL1B IL6 TLR9 TNF
17
Show member pathways
12.4 CD40LG IFNG IL17A IL1B IL6 TNF
18
Show member pathways
12.34 CRP IFNG IL1B IL6 TNF
19
Show member pathways
12.34 IFNG IL17A IL1B IL6 TNF
20
Show member pathways
12.27 IFNG IL1B IL6 TNF
21
Show member pathways
12.26 CD40LG HLA-DRB1 IFNG IL1B TNF
22
Show member pathways
12.22 IFNG IL1B TNF TNFRSF10A
23
Show member pathways
12.19 IFNG IL1B IL6 TLR9 TNF
24 12.18 IFNG IL6 TLR9 TNF
25 12.16 HLA-DRB1 IFNG IL1B IL6 TLR9 TNF
26
Show member pathways
12.14 IFNG IL17A IL1B IL6 TNF
27 12.06 IFNG IL1B TNF
28 12.03 IFNG IL1B IL6 TNF
29 12.02 IFNG IL1B TNF
30 12 IL17A IL1B IL6 TNF
31 11.97 IFNG IL6 TNF
32
Show member pathways
11.96 HLA-DRB1 IFNG IL1B
33 11.93 IL1B IL6 TNF
34 11.92 IFNG IL1B IL6
35 11.92 HLA-DRB1 IL1B IL6 TNF
36 11.91 IFNG IL1B IL6 TNF
37 11.89 IL1B IL6 TNF
38 11.87 CD40LG IL1B TNF
39
Show member pathways
11.86 IFNG IL17A IL1B IL6 TLR9 TNF
40
Show member pathways
11.83 IFNG IL17A IL1B IL6 TLR9
41 11.82 IFNG IL1B IL6
42 11.82 IFNG IL17A IL1B TNF
43
Show member pathways
11.8 CD40LG TNF TNFRSF10A
44
Show member pathways
11.76 CD40LG IFNG TNF
45 11.76 IL1B IL6 TNF
46 11.72 CD40LG IL6 TLR9 TNF
47 11.72 IFNG IL1B IL6 TLR9 TNF
48 11.67 IL1B IL6 TNF
49 11.61 IL1B IL6 TNF
50
Show member pathways
11.6 CD40LG IFNG IL1B IL6 TNF

GO Terms for Central Nervous System Vasculitis

Cellular components related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CD40LG CRP IFNG IL17A IL1B IL6
2 external side of plasma membrane GO:0009897 9.46 CD40LG HLA-DRB1 IL17A TNF
3 extracellular space GO:0005615 9.23 CD40LG CRP IFNG IL17A IL1B IL6

Biological processes related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.91 CD40LG IFNG IL17A IL1B IL6 TNF
2 positive regulation of gene expression GO:0010628 9.88 CRP IFNG IL1B IL6 TLR9 TNF
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.84 CD40LG TNF TNFRSF10A
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 IL1B IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.83 CRP IL6 TNF
6 positive regulation of JNK cascade GO:0046330 9.8 IL1B TLR9 TNF
7 regulation of insulin secretion GO:0050796 9.79 IFNG IL1B TNF
8 positive regulation of T cell proliferation GO:0042102 9.79 CD40LG IL1B IL6
9 humoral immune response GO:0006959 9.78 IFNG IL6 TNF
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 IFNG IL1B TNF
11 extrinsic apoptotic signaling pathway GO:0097191 9.73 IFNG TNF TNFRSF10A
12 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR9 TNF
13 positive regulation of interleukin-12 production GO:0032735 9.7 CD40LG IFNG TLR9
14 positive regulation of NF-kappaB import into nucleus GO:0042346 9.69 IL1B TLR9 TNF
15 negative regulation of lipid catabolic process GO:0050995 9.67 IL1B TNF
16 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG IL17A TNF
17 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.66 IL1B TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL1B TNF
19 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.65 IL1B TLR9
20 positive regulation of chemokine production GO:0032722 9.65 IL6 TLR9 TNF
21 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 CD40LG IL1B IL6 TLR9 TNF
22 positive regulation of chemokine biosynthetic process GO:0045080 9.64 IL1B TNF
23 positive regulation of histone phosphorylation GO:0033129 9.64 CDK9 IL1B
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IFNG IL1B TNF
25 regulation of establishment of endothelial barrier GO:1903140 9.62 IL1B TNF
26 positive regulation of interleukin-6 production GO:0032755 9.62 IL1B IL6 TLR9 TNF
27 positive regulation of interleukin-23 production GO:0032747 9.6 IFNG IL17A
28 positive regulation of fever generation GO:0031622 9.59 IL1B TNF
29 regulation of immunoglobulin secretion GO:0051023 9.58 CD40LG TNF
30 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
31 immune response GO:0006955 9.56 CD40LG HLA-DRB1 IFNG IL17A IL1B IL6
32 positive regulation of vitamin D biosynthetic process GO:0060557 9.55 IFNG TNF
33 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.33 IFNG IL1B TNF
35 inflammatory response GO:0006954 9.23 CD40LG CRP IL17A IL1B IL6 TLR9
36 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 CDK9 IL17A IL1B IL6 TLR9 TNF

Molecular functions related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CD40LG IFNG IL17A IL1B IL6 TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR9

Sources for Central Nervous System Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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