MCID: CNT046
MIFTS: 46

Central Nervous System Vasculitis malady

Categories: Neuronal diseases, Cardiovascular diseases

Aliases & Classifications for Central Nervous System Vasculitis

Aliases & Descriptions for Central Nervous System Vasculitis:

Name: Central Nervous System Vasculitis 12 14
Vasculitis, Central Nervous System 69

Classifications:



External Ids:

Disease Ontology 12 DOID:525
MeSH 42 D020293
NCIt 47 C84622
UMLS 69 C0751878

Summaries for Central Nervous System Vasculitis

MalaCards based summary : Central Nervous System Vasculitis, also known as vasculitis, central nervous system, is related to hepatitis and uveitis. An important gene associated with Central Nervous System Vasculitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs alemtuzumab and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and endothelial, and related phenotypes are immune system and integument

Related Diseases for Central Nervous System Vasculitis

Diseases related to Central Nervous System Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 336)
id Related Disease Score Top Affiliating Genes
1 hepatitis 30.0 HLA-DRB1 IL6 TNF
2 uveitis 29.4 CD4 CD40LG TNF
3 histiocytosis 29.4 CRP IL1B IL6 TNF
4 rheumatoid arthritis 28.9 CD40LG CRP HLA-DRB1 IL1B IL6 TNF
5 primary angiitis of the central nervous system 11.3
6 vasculitis 10.8
7 coloboma of iris 10.3 CRP IL6
8 fallopian tube adenomatoid tumor 10.3 CRP SMUG1
9 hordeolum 10.3 CD40LG SMUG1
10 cutaneous sclerosis 10.3 CRP IL6
11 adrenal gland ganglioneuroblastoma 10.2 CD40LG TNFRSF10A
12 shoulder impingement syndrome 10.2 CRP IL6
13 polycythemia due to hypoxia 10.2 CD40LG CRP
14 lipodystrophy, familial partial, type 1 10.2 CD8A CRP
15 cannabis dependence 10.2 CD40LG CRP
16 cerebritis 10.2
17 female breast upper-inner quadrant cancer 10.2 CRP SMUG1 TNFRSF10A
18 neutrophilia, hereditary 10.2 CRP IL6
19 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
20 luxation of globe 10.2 CRP IL6 SMUG1
21 apple allergy 10.2 CD8A HLA-DRB1
22 sclerosing breast papilloma 10.2 CD40LG SMUG1
23 artery disease 10.2 CD40LG CRP SMUG1
24 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DRB1 TNF
25 mirizzi syndrome 10.2 HLA-DRB1 TNF
26 dyslexia 5 10.2 IL6 TNF
27 mild pre-eclampsia 10.2 CD40LG CD8A
28 aortic atherosclerosis 10.2 IL6 TNF
29 degenerative disc disease 10.2 IL6 TNF
30 steatitis 10.2 CD8A TNF
31 postcricoid region cancer 10.2 CD40LG CD8A
32 hypertropia 10.2 CRP SMUG1 TNF
33 autosomal dominant intermediate charcot-marie-tooth 10.1 HLA-DRB1 TNF
34 distal trisomy 14q 10.1 HLA-DRB1 TNF
35 retinal degeneration 10.1 CD40LG CRP IL6
36 homocystinuria 10.1 CD40LG TNFRSF10A
37 oculomotor nerve paralysis 10.1 IL1B IL6
38 common peroneal nerve lesion 10.1 IL1B IL6
39 intussusception 10.1 IL1B TNF
40 thymic neuroendocrine carcinoma 10.1 IL6 TNF
41 hyperoxaluria, primary, type ii 10.1 CD8A TNF
42 unilateral multicystic dysplastic kidney 10.1 CRP IL6 TNF
43 joint disorders 10.1 CRP IL6 TNF
44 cicatricial lagophthalmos 10.1 CRP IL6 TNF
45 viral infectious disease 10.1 CD4 SMUG1
46 reproductive system disease 10.1 CD40LG HLA-DRB1 IL6
47 autoimmune disease of central nervous system 10.1 CRP IL6 TNF
48 submandibular gland disease 10.1 CD40LG TNF
49 retinal cancer 10.1 CRP IL1B
50 leiomyosarcoma 10.1 CD40LG CRP

Graphical network of the top 20 diseases related to Central Nervous System Vasculitis:



Diseases related to Central Nervous System Vasculitis

Symptoms & Phenotypes for Central Nervous System Vasculitis

MGI Mouse Phenotypes related to Central Nervous System Vasculitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.86 CD4 CD40LG CD8A CRP IL1B IL6
2 integument MP:0010771 9.7 TNF CD4 CD40LG CD8A CDK9 IL1B
3 mortality/aging MP:0010768 9.61 CD4 CD40LG CD8A CDK9 IL1B IL6
4 neoplasm MP:0002006 9.02 IL1B IL6 SMUG1 TNF TNFRSF10A

Drugs & Therapeutics for Central Nervous System Vasculitis

Drugs for Central Nervous System Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 146)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 4,Phase 2 216503-57-0
2
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
3
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2 50-18-0, 6055-19-2 2907
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
7
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
8
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
9
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
10
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
11
rituximab Approved Phase 4,Phase 3,Phase 2 174722-31-7 10201696
12
Glatiramer Acetate Approved, Investigational Phase 4 147245-92-9 3081884
13
Dalteparin Approved Phase 4 9041-08-1
14
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
15
Ibuprofen Approved Phase 4 15687-27-1 3672
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
18 Alkylating Agents Phase 4,Phase 3,Phase 2
19 Antimetabolites Phase 4,Phase 3,Phase 2
20 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
21 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2
22 Antirheumatic Agents Phase 4,Phase 3,Phase 2
23 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
24 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
26 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
27 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
28 Hormones Phase 4,Phase 2,Phase 3,Phase 1
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
30 Antiemetics Phase 4,Phase 2,Phase 3
31 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
32 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
33 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
34 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
35 Neuroprotective Agents Phase 4,Phase 2,Phase 3
36 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Prednisolone acetate Phase 4,Phase 2,Phase 3
38 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
39 Prednisolone phosphate Phase 4,Phase 2,Phase 3
40 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
43 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
45 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
46 Vitamin B Complex Phase 4,Phase 3,Phase 2
47 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
48 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
49 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
50 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 132)
id Name Status NCT ID Phase
1 Alemtuzumab for ANCA Associated Refractory Vasculitis Unknown status NCT01405807 Phase 4
2 CHUSPAN PAN BP Treatment of Polyarteritis Nodosa and Microscopic Polyangiitis Without Poor-Prognosis Factors Unknown status NCT00400075 Phase 4
3 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4
4 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4
5 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4
6 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4
7 Glatiramer Acetate for Multiple Sclerosis With Autoimmune Comorbidities Completed NCT01456416 Phase 4
8 Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease Completed NCT01524939 Phase 4
9 Management of Superficial Thrombophlebitis Completed NCT00264381 Phase 4
10 Low-dose Glucocorticoid Vasculitis Induction Study Recruiting NCT02198248 Phase 4
11 A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis Recruiting NCT02115997 Phase 4
12 A Multi-center, Randomized to Compare the Efficacy of IVIG Alone and IVIG Plus High-dose Aspirin in Kawasaki Disease Recruiting NCT02951234 Phase 4
13 Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis Active, not recruiting NCT02169219 Phase 4
14 Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) Unknown status NCT00103792 Phase 3
15 Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica Unknown status NCT01423591 Phase 3
16 Efficacy of Humira in Behcet Patients With Arthritis Completed NCT01497717 Phase 3
17 Pulse Versus Continuous Cyclophosphamide for Induction of Remission in ANCA-Associated Vasculitides Completed NCT00430105 Phase 2, Phase 3
18 Efficacy Study of Two Treatments in the Remission of Vasculitis Completed NCT00748644 Phase 3
19 Belimumab in Remission of VASculitis Completed NCT01663623 Phase 3
20 Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis Completed NCT00104299 Phase 2, Phase 3
21 Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Completed NCT00647166 Phase 3
22 Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol. Completed NCT00138983 Phase 3
23 Etanercept Treatment in the Early Course of Polymyalgia Rheumatica Completed NCT00524381 Phase 3
24 Timed Release Tablet Prednisone in Polymyalgia Rheumatica Completed NCT00836810 Phase 2, Phase 3
25 Hydroxychloroquine in Giant Cell Arteritis Completed NCT00430807 Phase 3
26 HECTHOR: Humira to Spare Steroids in Giant Cell Arteritis Completed NCT00305539 Phase 3
27 Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) Completed NCT00000517 Phase 3
28 Etanercept for Wegener's Granulomatosis Completed NCT00005007 Phase 2, Phase 3
29 Efficacy and Safety Study of Sirukumab in Patients With Giant Cell Arteritis Recruiting NCT02531633 Phase 3
30 Safety and Efficacy of tocilizuMAb Versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence SEMAPHORE Recruiting NCT02908217 Phase 3
31 Evolution of Albumin on AOA1 Patients Supplemented With Coenzyme Q10 Recruiting NCT02333305 Phase 3
32 Belimumab in Myositis Recruiting NCT02347891 Phase 2, Phase 3
33 Rituximab Vasculitis Maintenance Study Active, not recruiting NCT01697267 Phase 3
34 Comparison Study of Two Rituximab Regimens in the Remission of ANCA Associated Vasculitis Active, not recruiting NCT01731561 Phase 3
35 Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis Active, not recruiting NCT00987389 Phase 3
36 An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA) Active, not recruiting NCT01791153 Phase 3
37 A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behcet's Disease Active, not recruiting NCT02307513 Phase 3
38 Giant Cell Arteritis and Anakinra Trial Not yet recruiting NCT02902731 Phase 3
39 Efficacy and Safety Study of Sirukumab in Subjects With Polymyalgia Rheumatica Not yet recruiting NCT02899026 Phase 3
40 GnRH-a for Ovarian Protection During CYC Therapy for Rheumatic Diseases Terminated NCT01257802 Phase 3
41 Intravenous Immunoglobulin After Relapse in Vasculitis Terminated NCT00307658 Phase 3
42 IMPROVE: Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy in ANCA Associated Systemic Vasculitis Terminated NCT00307645 Phase 3
43 Plasma Exchange for Renal Vasculitis Terminated NCT01408836 Phase 2, Phase 3
44 A Study Assessing the Efficacy and Safety of Lodotra® Compared to Prednisone IR in Subjects Suffering From PMR Terminated NCT01821040 Phase 3
45 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides Unknown status NCT00751517 Phase 2
46 Evaluation of Tocilizumab as an add-on Therapy to Corticoids in Horton's Disease: Proof of Concept Study. Unknown status NCT01910038 Phase 2
47 Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia Areata Unknown status NCT01840046 Phase 1, Phase 2
48 Anti-Cytokine Therapy for Vasculitis Completed NCT00753103 Phase 2
49 Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis Completed NCT00556439 Phase 2
50 Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritis Completed NCT00004686 Phase 2

Search NIH Clinical Center for Central Nervous System Vasculitis

Genetic Tests for Central Nervous System Vasculitis

Anatomical Context for Central Nervous System Vasculitis

MalaCards organs/tissues related to Central Nervous System Vasculitis:

39
Brain, Testes, Endothelial, Spinal Cord

Publications for Central Nervous System Vasculitis

Articles related to Central Nervous System Vasculitis:

(show top 50) (show all 146)
id Title Authors Year
1
Successful Treatment of Central Nervous System Vasculitis Associated with Relapsing Polychondritis With Cyclophosphamide. ( 28502337 )
2017
2
Usual and Unusual Manifestations of Systemic and Central Nervous System Vasculitis. ( 27894445 )
2017
3
Central nervous system vasculitis in adults: An update. ( 28087351 )
2017
4
Central nervous system vasculitis in adults and children. ( 27112683 )
2016
5
354a88Diagnostic Utility of Cerebral Biopsy Following Suggestive Cerebral Angiogram in the Workup of Central Nervous System Vasculitis. ( 27399552 )
2016
6
High-Resolution Vessel Wall MRI : Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis. ( 27530660 )
2016
7
A case of primary central nervous system vasculitis diagnosed by second brain biopsy and treated successfully. ( 26960271 )
2016
8
Primary Central Nervous System Vasculitis With Optic Nerve Involvement. ( 26693942 )
2016
9
Central nervous system vasculitis in pediatric microscopic polyangiitis: A case report and review of literature. ( 27156236 )
2016
10
The Role of Catheter Angiography in the Diagnosis of Central Nervous System Vasculitis. ( 27781050 )
2016
11
Isolated Central Nervous System Vasculitis as a Manifestation of Neurosarcoidosis. ( 27083067 )
2016
12
Management of primary and secondary central nervous system vasculitis. ( 26599380 )
2016
13
Adult primary central nervous system vasculitis treatment and course: Analysis of 163 patients. ( 25708615 )
2015
14
An update of the Mayo Clinic cohort of patients with adult primary central nervous system vasculitis: description of 163 patients. ( 26020379 )
2015
15
Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis. ( 25425493 )
2015
16
Primary central nervous system vasculitis preceded by granulomatous hypophysitis: Case report with a review of the literature. ( 26539311 )
2015
17
Mycophenolate mofetil in primary central nervous system vasculitis. ( 25800827 )
2015
18
High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. ( 24722305 )
2014
19
Unilateral chronic relapsing primary central nervous system vasculitis. ( 24528778 )
2014
20
Late onset Leigh syndrome mimicking central nervous system vasculitis. ( 27896101 )
2014
21
Catastrophic primary central nervous system vasculitis. ( 24854370 )
2014
22
Varicella zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with natalizumab. ( 24479415 )
2014
23
Diagnosis and classification of central nervous system vasculitis. ( 24491822 )
2014
24
Crohns disease with central nervous system vasculitis causing subarachnoid hemorrhage due to aneurysm and cerebral ischemic stroke. ( 25506170 )
2014
25
Central Nervous System vasculitis associated with Hepatitis C virus infection: A brain MRI-supported diagnosis. ( 24211061 )
2014
26
Central nervous system vasculitis. ( 23475760 )
2013
27
Circulating endothelial cells as potential diagnostic biomarkers in primary central nervous system vasculitis. ( 23243263 )
2013
28
Central nervous system vasculitis associated with linear scleroderma. ( 23466848 )
2013
29
L36. Evidence-based clinical science and art in the diagnosis of central nervous system vasculitis. ( 23474051 )
2013
30
Childhood central nervous system vasculitis. ( 23622312 )
2013
31
Febrile ulceronecrotic Mucha-Habermann disease with central nervous system vasculitis. ( 22276640 )
2013
32
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. ( 23710607 )
2013
33
Childhood central nervous system vasculitis. ( 23608691 )
2013
34
Central nervous system vasculitis secondary to systemic sclerosis. ( 23664129 )
2013
35
Vessel wall enhancement in herpes simplex virus central nervous system vasculitis. ( 23517674 )
2013
36
Central Nervous System Vasculitis. ( 24435038 )
2013
37
Pseudotumoral presentation of primary central nervous system vasculitis. ( 23689414 )
2013
38
Malignant perivascular melanoma mimicking primary central nervous system vasculitis. ( 23263476 )
2013
39
Adult primary central nervous system vasculitis. ( 22575778 )
2012
40
von Willebrand factor antigen--a possible biomarker of disease activity in childhood central nervous system vasculitis? ( 22740622 )
2012
41
Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C. ( 22253526 )
2012
42
Vessel wall MRI to differentiate between reversible cerebral vasoconstriction syndrome and central nervous system vasculitis: preliminary results. ( 22156692 )
2012
43
Adult primary central nervous system vasculitis: an update. ( 22157412 )
2012
44
Refractory primary central nervous system vasculitis of childhood: successful treatment with infliximab. ( 23118297 )
2012
45
Primary central nervous system vasculitis presenting as spinal subdural hematoma. ( 22120304 )
2012
46
A rare association of localized scleroderma type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. Case report. ( 23256875 )
2012
47
Recent understanding on diagnosis and management of central nervous system vasculitis in children. ( 23008735 )
2012
48
Primary and secondary central nervous system vasculitis. ( 23006496 )
2012
49
Fatal exserohilum meningitis and central nervous system vasculitis after cervical epidural methylprednisolone injection. ( 23277893 )
2012
50
Primary central nervous system vasculitis: pathology and mechanisms. ( 22421812 )
2012

Variations for Central Nervous System Vasculitis

Expression for Central Nervous System Vasculitis

Search GEO for disease gene expression data for Central Nervous System Vasculitis.

Pathways for Central Nervous System Vasculitis

Pathways related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 CD4 CD40LG IL1B IL6 TNF TNFRSF10A
2
Show member pathways
13.26 CD4 CD40LG HLA-DRB1 IL1B IL6 TNF
3
Show member pathways
13.2 CD4 CD40LG IL1B IL6 TNF TNFRSF10A
4
Show member pathways
12.8 CD4 IL6 TNF TNFRSF10A
5
Show member pathways
12.72 HLA-DRB1 IL1B IL6 TNF TNFRSF10A
6
Show member pathways
12.63 CD40LG IL1B IL6 TNF
7
Show member pathways
12.59 CD4 CD40LG IL1B TNF
8
Show member pathways
12.57 CD4 CD40LG HLA-DRB1 TNF
9
Show member pathways
12.54 CD40LG IL1B TNF TNFRSF10A
10
Show member pathways
12.54 CD4 CD40LG CD8A HLA-DRB1 IL1B IL6
11
Show member pathways
12.52 CD4 IL1B IL6 TNF
12
Show member pathways
12.47 CD4 HLA-DRB1 IL1B IL6 TNF
13 12.46 CD40LG CD8A IL1B TNF
14
Show member pathways
12.27 CRP IL1B IL6 TNF
15
Show member pathways
12.21 CD4 CD40LG CD8A IL1B IL6 TNF
16
Show member pathways
12.2 IL1B IL6 TNF
17
Show member pathways
12.19 CD40LG HLA-DRB1 IL1B TNF
18 12.15 HLA-DRB1 IL1B IL6 TNF
19
Show member pathways
12.12 IL1B IL6 TNF
20 12.11 IL1B IL6 TNF
21
Show member pathways
12.1 IL1B IL6 TNF
22 12.03 CD4 CD40LG CD8A HLA-DRB1
23 11.96 IL1B IL6 TNF
24 11.93 IL1B IL6 TNF
25
Show member pathways
11.9 CD4 CD8A HLA-DRB1
26 11.9 IL1B IL6 TNF
27 11.89 CD4 CD8A IL6 TNF
28
Show member pathways
11.87 CD4 IL1B IL6
29
Show member pathways
11.86 CD4 CD8A HLA-DRB1 IL1B
30 11.85 IL1B IL6 TNF
31 11.83 IL1B IL6 TNF
32 11.83 CD40LG IL1B TNF
33
Show member pathways
11.83 CD4 IL1B IL6 TNF
34
Show member pathways
11.77 CD40LG TNF TNFRSF10A
35 11.71 IL1B IL6 TNF
36 11.71 HLA-DRB1 IL1B IL6 TNF
37 11.68 CD4 CD8A HLA-DRB1
38 11.67 CD40LG IL6 TNF
39 11.64 CD4 CD8A IL1B TNF
40 11.62 IL1B IL6 TNF
41 11.55 IL1B IL6 TNF
42
Show member pathways
11.5 CD40LG IL1B IL6 TNF
43 11.49 IL1B IL6 TNF
44 11.43 IL1B IL6 TNF
45 11.43 CD4 CD8A IL1B IL6 TNF
46 11.42 CD4 CD8A HLA-DRB1 IL1B IL6 TNF
47 11.36 CD40LG IL1B IL6 TNF
48 11.34 CD4 CD40LG CD8A
49 11.3 IL1B IL6 TNF
50 11.3 IL1B IL6 TNF

GO Terms for Central Nervous System Vasculitis

Cellular components related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.43 CD4 CD40LG CD8A HLA-DRB1 TNF TNFRSF10A
2 T cell receptor complex GO:0042101 9.16 CD4 CD8A
3 external side of plasma membrane GO:0009897 9.1 CD4 CD40LG CD8A HLA-DRB1 IL6 TNF

Biological processes related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.91 CRP IL1B IL6 TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.83 CD4 IL1B TNF
3 positive regulation of protein phosphorylation GO:0001934 9.82 CD4 IL1B TNF
4 tumor necrosis factor-mediated signaling pathway GO:0033209 9.79 CD40LG TNF TNFRSF10A
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.77 IL1B IL6 TNF
6 T cell costimulation GO:0031295 9.73 CD4 CD40LG HLA-DRB1
7 defense response to Gram-positive bacterium GO:0050830 9.71 CRP IL6 TNF
8 T cell activation GO:0042110 9.65 CD4 CD8A IL6
9 positive regulation of NF-kappaB import into nucleus GO:0042346 9.64 IL1B TNF
10 positive regulation of calcium-mediated signaling GO:0050850 9.64 CD4 CD8A
11 negative regulation of lipid catabolic process GO:0050995 9.63 IL1B TNF
12 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B TNF
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.62 CD40LG IL1B IL6 TNF
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.61 IL1B TNF
16 positive regulation of interleukin-6 production GO:0032755 9.61 IL1B IL6 TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 IL1B TNF
18 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.58 CD4 IL1B
19 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B IL6 TNF
21 positive regulation of histone phosphorylation GO:0033129 9.57 CDK9 IL1B
22 positive regulation of T cell proliferation GO:0042102 9.56 CD4 CD40LG IL1B IL6
23 regulation of establishment of endothelial barrier GO:1903140 9.55 IL1B TNF
24 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.52 IL6 TNF
25 positive regulation of fever generation GO:0031622 9.51 IL1B TNF
26 regulation of immunoglobulin secretion GO:0051023 9.49 CD40LG TNF
27 sequestering of triglyceride GO:0030730 9.46 IL1B TNF
28 inflammatory response GO:0006954 9.43 CD40LG CRP IL1B IL6 TNF TNFRSF10A
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IL1B TNF
30 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
31 immune response GO:0006955 9.23 CD4 CD40LG CD8A HLA-DRB1 IL1B IL6

Molecular functions related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CD40LG IL1B IL6 TNF

Sources for Central Nervous System Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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