MCID: CNT046
MIFTS: 38

Central Nervous System Vasculitis malady

Neuronal diseases, Cardiovascular diseases categories
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Summaries for Central Nervous System Vasculitis

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33MalaCards
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MalaCards: Central Nervous System Vasculitis, also known as vasculitis, central nervous system, is related to vasculitis and cerebritis. An important gene associated with Central Nervous System Vasculitis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Integrated Pancreatic Cancer Pathway and RNA Polymerase I Promoter Opening. The compounds aebsf and ndga have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are muscle and no phenotypic analysis.

Aliases & Classifications for Central Nervous System Vasculitis

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Sources:
8Disease Ontology, 62UMLS, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Cardiovascular diseases


Aliases & Descriptions:

central nervous system vasculitis 8
vasculitis, central nervous system 62


External Ids:

Disease Ontology8 DOID:525
MeSH35 D020293
NCIt40 C84622

Related Diseases for Central Nervous System Vasculitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Central Nervous System Vasculitis:



Diseases related to central nervous system vasculitis

Symptoms for Central Nervous System Vasculitis

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Drugs & Therapeutics for Central Nervous System Vasculitis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Central Nervous System Vasculitis

Search NIH Clinical Center for Central Nervous System Vasculitis

Genetic Tests for Central Nervous System Vasculitis

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Anatomical Context for Central Nervous System Vasculitis

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33MalaCards
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MalaCards organs/tissues related to Central Nervous System Vasculitis:

33
Brain, Spinal cord, Testes, Endothelial

Animal Models for Central Nervous System Vasculitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Central Nervous System Vasculitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1APP, TNF
2MP:00030128.8APP, TNF

Publications for Central Nervous System Vasculitis

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52PubMed
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Articles related to Central Nervous System Vasculitis:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Malignant perivascular melanoma mimicking primary central nervous system vasculitis. (23263476)
2013
2
Childhood central nervous system vasculitis. (23608691)
2013
3
Central nervous system vasculitis. (23475760)
2013
4
L36. Evidence-based clinical science and art in the diagnosis of central nervous system vasculitis. (23474051)
2013
5
Childhood central nervous system vasculitis. (23622312)
2013
6
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. (23710607)
2013
7
Recent understanding on diagnosis and management of central nervous system vasculitis in children. (23008735)
2012
8
Possible central nervous system vasculitis as an early presentation of Crohn's disease. A challenge in diagnosis and management. (22964818)
2012
9
Cerebral haemorrhage in the presence of primary childhood central nervous system vasculitis--a review. (22684518)
2012
10
von Willebrand factor antigen--a possible biomarker of disease activity in childhood central nervous system vasculitis? (22740622)
2012
11
Vessel wall MRI to differentiate between reversible cerebral vasoconstriction syndrome and central nervous system vasculitis: preliminary results. (22156692)
2012
12
Refractory primary central nervous system vasculitis of childhood: successful treatment with infliximab. (23118297)
2012
13
Rapidly progressive primary central nervous system vasculitis. (20959356)
2011
14
Primary central nervous system vasculitis presenting with intracranial hemorrhage. (22038406)
2011
15
Isolated central nervous system vasculitis associated with antiribonuclear protein antibody. (22937341)
2011
16
Central nervous system vasculitis: still more questions than answers. (22379458)
2011
17
Two uncommon manifestations of leptospirosis: Sweet's syndrome and central nervous system vasculitis. (21771425)
2011
18
Investigation of childhood central nervous system vasculitis: magnetic resonance angiography versus catheter cerebral angiography. (20132140)
2010
19
Primary central nervous system vasculitis and moyamoya disease: similarities and differences. (20037765)
2010
20
The role of imaging in the diagnosis of central nervous system vasculitis. (20425011)
2010
21
Primary central nervous system vasculitis: Is it a single disease? (21031572)
2010
22
Primary central nervous system vasculitis mimicking brain tumour: case report and literature review. (19370353)
2009
23
Angiographic diagnosis of primary central nervous system vasculitis with spinal cord involvement. (19364941)
2009
24
Refractory central nervous system vasculitis and gastrocnemius myalgia syndrome in Crohn's disease successfully treated with anti-tumor necrosis factor-alpha antibody. (18304612)
2009
25
Unusual cause of acute neurologic deficit in childhood: primary central nervous system vasculitis presenting with basilar arterial occlusion. (18690464)
2009
26
Central nervous system vasculitis. (19908043)
2009
27
Primary central nervous system vasculitis: is biopsy appropriate? (18350582)
2008
28
Brain abscess formation at the site of intracerebral hemorrhage secondary to central nervous system vasculitis. (18518742)
2008
29
Central nervous system vasculitis after starting methimazole in a woman with Graves' disease. (18788922)
2008
30
Primary central nervous system vasculitis with prominent leptomeningeal enhancement: a subset with a benign outcome. (18240248)
2008
31
Angiography-negative primary central nervous system vasculitis: a syndrome involving small cerebral vessels. (18794709)
2008
32
Efficacy of tumor necrosis factor alpha blockade in primary central nervous system vasculitis resistant to immunosuppressive treatment. (18240197)
2008
33
Primary central nervous system vasculitis: comparison of patients with and without cerebral amyloid angiopathy. (18753193)
2008
34
Central nervous system vasculitis. (12774201)
2003
35
Central nervous system vasculitis in the intensive care unit. (12418446)
2002
36
Unusual and instructive case of immune-mediated inner ear disease associated with central nervous system vasculitis. (10629494)
2000
37
Intravenous gammaglobulin in the treatment of central nervous system vasculitis associated with SjAPgren's syndrome. (10782846)
2000
38
Central nervous system vasculitis. (9642543)
1998
39
Uveitis and central nervous system vasculitis. (9517787)
1998
40
Central nervous system vasculitis in systemic lupus erythematosus: a case successfully treated with cyclophosphamide and steroids. (19078225)
1997
41
Classification and histopathologic spectrum of central nervous system vasculitis. (9367965)
1997
42
Radiographic features of central nervous system vasculitis. (9367964)
1997
43
Response of central nervous system vasculitis to irradiation. (1673534)
1991
44
Magnetic resonance imaging of central nervous system vasculitis. A case report of Henoch-SchAPnlein purpura. (2386069)
1990
45
Ephedrine-induced intracerebral hemorrhage and central nervous system vasculitis. (2237962)
1990
46
Phenylpropanolamine: an over-the-counter drug causing central nervous system vasculitis and intracerebral hemorrhage. Case report and review. (2956531)
1987
47
Central nervous system vasculitis. (3826768)
1987
48
Florid central nervous system vasculitis in a fatal case of systemic lupus erythematosus. (7175846)
1982
49
Intravascular malignant histiocytosis mimicking central nervous system vasculitis: an immunopathological diagnostic approach. (6758680)
1982
50
Central nervous system vasculitis in rheumatoid arthritis. (597801)
1977

Variations for Central Nervous System Vasculitis

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Expression for genes affiliated with Central Nervous System Vasculitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Nervous System Vasculitis

Search GEO for disease gene expression data for Central Nervous System Vasculitis.

Pathways for genes affiliated with Central Nervous System Vasculitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 53QIAGEN, 57SinoBiological, 54R&D Systems, 60Thomson Reuters
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Pathways related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1TNF, APP
2
Show member pathways
9.1TNF, APP
3
Show member pathways
9.1TNF, APP
4
Show member pathways
Alzheimers Disease38
9.1TNF, APP
5
Show member pathways
9.1APP, TNF
6
Show member pathways
9.1APP, TNF
7
Show member pathways
9.1APP, TNF
8
Show member pathways
Delta-Notch Signaling Pathway38
Notch Signaling Pathway38
9.1TNF, APP
9
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.1APP, TNF

Compounds for genes affiliated with Central Nervous System Vasculitis

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Sources:
45Novoseek, 3BitterDB, 51PharmGKB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB
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Compounds related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1aebsf459.5TNF, APP
2ndga459.4TNF, APP
3c2ceramide459.4APP, TNF
4chloroquine45 3 51 29 1113.4TNF, APP
5lactacystin459.4TNF, APP
6egcg459.4APP, TNF
7simvastatin45 51 61 29 24 1114.4APP, TNF
8curcumin459.4APP, TNF
9tacrolimus45 51 1111.4TNF, APP
10methotrexate51 45 1111.3TNF, APP
11butyrate459.3TNF, APP
12actinomycin d459.3TNF, APP
13cyclosporin a45 29 6111.2TNF, APP
14h2o2459.2TNF, APP
15dexamethasone45 51 29 1112.1APP, TNF
16lipid459.1TNF, APP
17vegf459.0TNF, APP
18retinoic acid45 249.8TNF, APP

GO Terms for genes affiliated with Central Nervous System Vasculitis

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16Gene Ontology
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Cellular components related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.1APP, TNF
2cell surfaceGO:0099868.8APP, TNF

Biological processes related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459449.1APP, TNF
2extracellular matrix organizationGO:0301988.8APP, TNF

Molecular functions related to Central Nervous System Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1APP, TNF

Products for genes affiliated with Central Nervous System Vasculitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Nervous System Vasculitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet