MCID: CNT046
MIFTS: 45

Central Nervous System Vasculitis

Categories: Neuronal diseases, Cardiovascular diseases

Aliases & Classifications for Central Nervous System Vasculitis

MalaCards integrated aliases for Central Nervous System Vasculitis:

Name: Central Nervous System Vasculitis 12 14
Vasculitis, Central Nervous System 69

Classifications:



External Ids:

Disease Ontology 12 DOID:525
MeSH 42 D020293
NCIt 47 C84622
UMLS 69 C0751878

Summaries for Central Nervous System Vasculitis

MalaCards based summary : Central Nervous System Vasculitis, also known as vasculitis, central nervous system, is related to toxoplasmosis and uveitis. An important gene associated with Central Nervous System Vasculitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs alemtuzumab and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include brain, neutrophil and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Related Diseases for Central Nervous System Vasculitis

Diseases related to Central Nervous System Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)
id Related Disease Score Top Affiliating Genes
1 toxoplasmosis 30.1 IL6 TNF
2 uveitis 29.5 CD40LG MPO TNF
3 inner ear disease 29.2 CD40LG IL6 TLR9 TNF
4 chickenpox 29.1 CD40LG CRP MPO TNF
5 lymphoma 26.7 CD40LG IL17A IL1B IL6 TLR9 TNF
6 systemic lupus erythematosus 26.6 CD40LG CRP HLA-DRB1 IL17A IL6 MPO
7 rheumatoid arthritis 26.6 CD40LG CRP HLA-DRB1 IL17A IL1B IL6
8 primary angiitis of the central nervous system 11.3
9 vasculitis 10.8
10 methotrexate-associated lymphoproliferation 10.7 SMUG1 TLR9
11 collagenopathy type 2 alpha 1 10.7 CRP IL6
12 crystal arthropathies 10.7 CRP IL6
13 shoulder impingement syndrome 10.7 CRP IL6
14 brachydactyly-distal symphalangism syndrome 10.7 CRP IL6
15 median arcuate ligament syndrome 10.6 CD40LG SMUG1
16 breast hemangiopericytoma 10.6 HLA-DRB1 TNFRSF10A
17 thrombocytopenia due to platelet alloimmunization 10.6 CDK9 SMUG1
18 acquired polycythemia 10.6 CD40LG CRP
19 morphine dependence 10.6 SMUG1 TNFRSF10A
20 peroneal nerve paralysis 10.6 IL6 TLR9
21 cerebral hemorrhage 10.6 CRP TNFRSF10A
22 leiomyosarcoma 10.6 CD40LG CRP
23 ocular motility disease 10.6 CD40LG SMUG1
24 erythema elevatum diutinum 10.6 CRP IL6
25 pancreatic vasoactive intestinal peptide producing tumor 10.6 CD40LG CRP
26 pseudovascular skin squamous cell carcinoma 10.6 CD40LG TNFRSF10A
27 chronic mucocutaneous candidiasis 10.5 CD40LG CRP
28 cataract congenital autosomal dominant 10.5 CRP IL6
29 hypertensive heart disease 10.5 CD40LG CRP
30 kidney carcinoma in situ 10.5 CD40LG TNFRSF10A
31 female breast upper-inner quadrant cancer 10.5 CRP SMUG1 TNFRSF10A
32 biemond syndrome 10.5 HLA-DRB1 TNF
33 myotonic cataract 10.5 CRP MPO
34 luxation of globe 10.5 CRP IL6 SMUG1
35 rocky mountain spotted fever 10.5 CD40LG CRP
36 smarca4-deficient sarcoma of thorax 10.4 IL6 TNF
37 mosaic trisomy 1 10.4 HLA-DRB1 TNF
38 prostate calculus 10.4 TNF TNFRSF10A
39 tracheal calcification 10.4 TLR9 TNF
40 chronic diarrhea due to guanylate cyclase 2c overactivity 10.4 CRP IL6
41 autoimmune retinopathy 10.4 HLA-DRB1 TNF
42 aortic arch interruption 10.4 IL6 TNF
43 generalized atherosclerosis 10.4 CD40LG IL6
44 euthyroid sick syndrome 10.4 CRP TNF
45 cutaneous leishmaniasis 10.4 IL6 TNF
46 rheumatic heart disease 10.4 CD40LG CRP SMUG1
47 axillary adenitis 10.4 CRP IL1B
48 spirillary rat-bite fever 10.4 IL6 TNF
49 somatoform disorder 10.4 CD40LG TLR9
50 hepatic encephalopathy 10.4 SMUG1 TNF

Graphical network of the top 20 diseases related to Central Nervous System Vasculitis:



Diseases related to Central Nervous System Vasculitis

Symptoms & Phenotypes for Central Nervous System Vasculitis

GenomeRNAi Phenotypes related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 MPO TNF TNFRSF10A CD40LG IL17A IL1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 MPO TNF TNFRSF10A CD40LG IL17A IL1B

MGI Mouse Phenotypes related to Central Nervous System Vasculitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 TNF TNFRSF10A CD40LG IL17A IL1B IL6
2 homeostasis/metabolism MP:0005376 9.85 SMUG1 TLR9 TNF TNFRSF10A CD40LG CRP
3 immune system MP:0005387 9.61 CD40LG CRP IL17A IL1B IL6 MPO
4 mortality/aging MP:0010768 9.32 CD40LG CDK9 IL17A IL1B IL6 MPO

Drugs & Therapeutics for Central Nervous System Vasculitis

Drugs for Central Nervous System Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 4 216503-57-0
2
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
3
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2 50-18-0, 6055-19-2 2907
4
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
6
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
7
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
8
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
9
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
10
rituximab Approved Phase 4,Phase 3,Phase 2 174722-31-7 10201696
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
12
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 143 6006
13 Alkylating Agents Phase 4,Phase 3,Phase 2
14 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
16 Antiemetics Phase 4,Phase 2,Phase 3
17 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
18 Antimetabolites Phase 4,Phase 3,Phase 2
19 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
20 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
21 Antirheumatic Agents Phase 4,Phase 3,Phase 2
22 Autonomic Agents Phase 4,Phase 2,Phase 3
23 Dermatologic Agents Phase 4,Phase 2
24 Folic Acid Antagonists Phase 4,Phase 2
25 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
26 glucocorticoids Phase 4,Phase 2,Phase 3
27 Hormone Antagonists Phase 4,Phase 2,Phase 3
28 Hormones Phase 4,Phase 2,Phase 3
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
30 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
32 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
33 Neuroprotective Agents Phase 4,Phase 2,Phase 3
34 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
35 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
36 Prednisolone acetate Phase 4,Phase 2,Phase 3
37 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
38 Prednisolone phosphate Phase 4,Phase 2,Phase 3
39 Protective Agents Phase 4,Phase 2,Phase 3
40 Vitamin B Complex Phase 4,Phase 2
41 Tin Fluorides Phase 4
42 Folate Nutraceutical Phase 4,Phase 2
43 Vitamin B9 Nutraceutical Phase 4,Phase 2
44
Adalimumab Approved Phase 3 331731-18-1 16219006
45
belimumab Approved Phase 3 356547-88-1 5957 10451420
46
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
47 Antibodies Phase 3,Phase 1,Phase 2
48 Antibodies, Monoclonal Phase 3,Phase 1,Phase 2
49 Immunoglobulins Phase 3,Phase 1,Phase 2
50 Antibodies, Antineutrophil Cytoplasmic Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 67)

id Name Status NCT ID Phase Drugs
1 Alemtuzumab for ANCA Associated Refractory Vasculitis Unknown status NCT01405807 Phase 4 Alemtuzumab
2 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
3 Low-dose Glucocorticoid Vasculitis Induction Study Recruiting NCT02198248 Phase 4 Rituximab;Glucocorticoids
4 A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis Recruiting NCT02115997 Phase 4 Methylprednisolone;Prednisone;Rituximab
5 Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis Active, not recruiting NCT02169219 Phase 4 Glucocorticoids;Rituximab
6 Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) Unknown status NCT00103792 Phase 3 mycophenolate mofetil;cyclophosphamide
7 Efficacy of Humira in Behcet Patients With Arthritis Completed NCT01497717 Phase 3 Adalimumab (Humira)
8 Pulse Versus Continuous Cyclophosphamide for Induction of Remission in ANCA-Associated Vasculitides Completed NCT00430105 Phase 2, Phase 3 cyclophosphamide
9 Efficacy Study of Two Treatments in the Remission of Vasculitis Completed NCT00748644 Phase 3 Rituximab;Azathioprine
10 Belimumab in Remission of VASculitis Completed NCT01663623 Phase 3 Azathioprine
11 Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis Completed NCT00104299 Phase 2, Phase 3 Rituximab plus cyclophosphamide placebo (rituximab group);Cyclophosphamide plus rituximab placebo (control group);Azathioprine;Methylprednisolone (or other glucocorticoid);Prednisone
12 Rituximab Vasculitis Maintenance Study Active, not recruiting NCT01697267 Phase 3 Azathioprine
13 Comparison Study of Two Rituximab Regimens in the Remission of ANCA Associated Vasculitis Active, not recruiting NCT01731561 Phase 3 Rituximab (Arm B);Rituximab (Arm A)
14 Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis Active, not recruiting NCT00987389 Phase 3 Glucocorticoids
15 Giant Cell Arteritis and Anakinra Trial Not yet recruiting NCT02902731 Phase 3 PLACEBO;ANAKINRA
16 GnRH-a for Ovarian Protection During CYC Therapy for Rheumatic Diseases Terminated NCT01257802 Phase 3 depot leuprolide acetate 3.75 mg;Placebo
17 Intravenous Immunoglobulin After Relapse in Vasculitis Terminated NCT00307658 Phase 3 Intravenous immunoglobulins (human immunoglobulins G)
18 IMPROVE: Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy in ANCA Associated Systemic Vasculitis Terminated NCT00307645 Phase 3 Cyclophosphamide;Mycophenolate mofetil;Azathioprine;Prednisone (and methylprednisolone)
19 Plasma Exchange for Renal Vasculitis Terminated NCT01408836 Phase 2, Phase 3 Intravenous methyl prednisolone;Methyl prednisolone
20 Phase Ib Study of SC Milatuzumab in SLE Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
21 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides Unknown status NCT00751517 Phase 2 Methotrexate;Cyclophosphamide
22 Anti-Cytokine Therapy for Vasculitis Completed NCT00753103 Phase 2 Cyclophosphamide;Prednisolone;Azathioprine;Mycophenolate mofetil;Methylprednisolone
23 Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis Completed NCT00556439 Phase 2 Abatacept;Placebo
24 Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritis Completed NCT00004686 Phase 2 methotrexate;prednisone
25 Study of Anti-Malarials in Incomplete Lupus Erythematosus Not yet recruiting NCT03030118 Phase 2 Hydroxychloroquine;Placebo Oral Capsule
26 BIANCA-SC: A Study of the Efficacy, Safety, and Tolerability of Blisibimod in Addition to Methotrexate During Induction of Remission in Subjects With ANCA-Associated Small Vessel Vasculitis Withdrawn NCT01598857 Phase 2 Blisibimod;Placebo
27 CellCept in p-ANCA Vasculitis Completed NCT00405860 Phase 1 CellCept (mycophenolate mofetil)
28 PRO Development for ANCA Associated Vasculitis Unknown status NCT01729624
29 Sensitivity and Specificity of Color Doppler Directed Temporal Artery Biopsy as Compared to Standard Random Biopsy in the Diagnosis of Temporal Arteritis Unknown status NCT00361192 Early Phase 1
30 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
31 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
32 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
33 Impact of Vasculitis on Employment and Income Completed NCT02476292
34 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
35 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
36 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002
37 RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides Completed NCT00307593 Infliximab;Rituximab
38 The ANCA Vasculitis Questionnaire (AAV-PRO©) Completed NCT02507024
39 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884
40 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671
41 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
42 Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis Completed NCT01795456
43 Vessel Wall Imaging for Diagnosis and Monitoring of Central Nervous System (CNS) Vasculitis Recruiting NCT03166319
44 Pediatric Vasculitis Initiative Recruiting NCT02006134
45 Vasculitis Pregnancy Registry Recruiting NCT02593565
46 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Recruiting NCT02456168
47 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Recruiting NCT01066208
48 One-Time DNA Study for Vasculitis Recruiting NCT01241305
49 Clinical Transcriptomics in Systemic Vasculitis (CUTIS) Recruiting NCT03004326
50 VCRC Tissue Repository Recruiting NCT02967068

Search NIH Clinical Center for Central Nervous System Vasculitis

Genetic Tests for Central Nervous System Vasculitis

Anatomical Context for Central Nervous System Vasculitis

MalaCards organs/tissues related to Central Nervous System Vasculitis:

39
Brain, Neutrophil, Liver, Spinal Cord, Endothelial, Testes

Publications for Central Nervous System Vasculitis

Articles related to Central Nervous System Vasculitis:

(show top 50) (show all 157)
id Title Authors Year
1
Association of primary central nervous system vasculitis with the presence of specific human leucocyte antigen gene variant. ( 28734234 )
2017
2
Pitfalls of PACNS: A Rare Case of Central Nervous System Vasculitis Associated with Toxoplasmosis. ( 28765346 )
2017
3
Magnetic resonance imaging in central nervous system vasculitis in a patient affected by crioglobulin-negative hepatitis C virus infection: A likely correlation. ( 28735554 )
2017
4
Case report of a 28-year-old male with the rapid progression of steroid-resistant central nervous system vasculitis diagnosed by a brain biopsy. ( 28804113 )
2017
5
Usual and Unusual Manifestations of Systemic and Central Nervous System Vasculitis. ( 27894445 )
2017
6
Central nervous system vasculitis in systemic lupus erythematosus: a case series report in a tertiary referral centre. ( 28420057 )
2017
7
Central nervous system vasculitis in adults: An update. ( 28087351 )
2017
8
Focal Hemispheric Central Nervous System Vasculitis: An Unusual Form Of Primary Angiitis. ( 28718271 )
2017
9
Primary central nervous system vasculitis and its mimicking diseases - clinical features, outcome, comorbidities and diagnostic results - A case control study. ( 28324788 )
2017
10
Successful Treatment of Central Nervous System Vasculitis Associated with Relapsing Polychondritis With Cyclophosphamide. ( 28502337 )
2017
11
Primary Central Nervous System Vasculitis Mimicking a Cortical Brain Tumor: A Case Report. ( 28516076 )
2017
12
Coccidioidal meningitis complicated by central nervous system vasculitis in a patient with leukemia. ( 28386527 )
2017
13
Concordance of Time-of-Flight MRA and Digital Subtraction Angiography in Adult Primary Central Nervous System Vasculitis. ( 28751515 )
2017
14
Adult Primary Central Nervous System Vasculitis. ( 28786262 )
2017
15
354a88Diagnostic Utility of Cerebral Biopsy Following Suggestive Cerebral Angiogram in the Workup of Central Nervous System Vasculitis. ( 27399552 )
2016
16
Isolated Central Nervous System Vasculitis as a Manifestation of Neurosarcoidosis. ( 27083067 )
2016
17
Primary Central Nervous System Vasculitis With Optic Nerve Involvement. ( 26693942 )
2016
18
Management of primary and secondary central nervous system vasculitis. ( 26599380 )
2016
19
Central nervous system vasculitis in pediatric microscopic polyangiitis: A case report and review of literature. ( 27156236 )
2016
20
A case of primary central nervous system vasculitis diagnosed by second brain biopsy and treated successfully. ( 26960271 )
2016
21
High-Resolution Vessel Wall MRI : Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis. ( 27530660 )
2016
22
The Role of Catheter Angiography in the Diagnosis of Central Nervous System Vasculitis. ( 27781050 )
2016
23
Central nervous system vasculitis in adults and children. ( 27112683 )
2016
24
Mycophenolate mofetil in primary central nervous system vasculitis. ( 25800827 )
2015
25
An update of the Mayo Clinic cohort of patients with adult primary central nervous system vasculitis: description of 163 patients. ( 26020379 )
2015
26
Adult primary central nervous system vasculitis treatment and course: Analysis of 163 patients. ( 25708615 )
2015
27
Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis. ( 25425493 )
2015
28
Primary central nervous system vasculitis preceded by granulomatous hypophysitis: Case report with a review of the literature. ( 26539311 )
2015
29
Unilateral chronic relapsing primary central nervous system vasculitis. ( 24528778 )
2014
30
Late onset Leigh syndrome mimicking central nervous system vasculitis. ( 27896101 )
2014
31
Catastrophic primary central nervous system vasculitis. ( 24854370 )
2014
32
Crohns disease with central nervous system vasculitis causing subarachnoid hemorrhage due to aneurysm and cerebral ischemic stroke. ( 25506170 )
2014
33
Central Nervous System vasculitis associated with Hepatitis C virus infection: A brain MRI-supported diagnosis. ( 24211061 )
2014
34
High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. ( 24722305 )
2014
35
Varicella zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with natalizumab. ( 24479415 )
2014
36
Diagnosis and classification of central nervous system vasculitis. ( 24491822 )
2014
37
Febrile ulceronecrotic Mucha-Habermann disease with central nervous system vasculitis. ( 22276640 )
2013
38
L36. Evidence-based clinical science and art in the diagnosis of central nervous system vasculitis. ( 23474051 )
2013
39
Circulating endothelial cells as potential diagnostic biomarkers in primary central nervous system vasculitis. ( 23243263 )
2013
40
Malignant perivascular melanoma mimicking primary central nervous system vasculitis. ( 23263476 )
2013
41
Central nervous system vasculitis secondary to systemic sclerosis. ( 23664129 )
2013
42
Vessel wall enhancement in herpes simplex virus central nervous system vasculitis. ( 23517674 )
2013
43
Central nervous system vasculitis associated with linear scleroderma. ( 23466848 )
2013
44
Central Nervous System Vasculitis. ( 24435038 )
2013
45
Central nervous system vasculitis. ( 23475760 )
2013
46
Childhood central nervous system vasculitis. ( 23622312 )
2013
47
Childhood central nervous system vasculitis. ( 23608691 )
2013
48
Pseudotumoral presentation of primary central nervous system vasculitis. ( 23689414 )
2013
49
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. ( 23710607 )
2013
50
Primary and secondary central nervous system vasculitis. ( 23006496 )
2012

Variations for Central Nervous System Vasculitis

Expression for Central Nervous System Vasculitis

Search GEO for disease gene expression data for Central Nervous System Vasculitis.

Pathways for Central Nervous System Vasculitis

Pathways related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 CD40LG CRP HLA-DRB1 IL17A IL1B IL6
2
Show member pathways
13.33 CD40LG IL17A IL1B IL6 TLR9 TNF
3
Show member pathways
13.29 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
4
Show member pathways
13.22 CD40LG IL17A IL1B IL6 TNF TNFRSF10A
5
Show member pathways
12.79 IL1B IL6 TLR9 TNF
6
Show member pathways
12.77 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
7
Show member pathways
12.71 HLA-DRB1 IL1B IL6 TLR9 TNF TNFRSF10A
8
Show member pathways
12.65 CD40LG IL1B IL6 TLR9 TNF
9
Show member pathways
12.57 CD40LG IL1B TLR9 TNF TNFRSF10A
10
Show member pathways
12.55 HLA-DRB1 IL17A IL1B IL6 TNF
11
Show member pathways
12.54 IL17A IL1B IL6 MPO TNF
12
Show member pathways
12.39 CD40LG IL17A IL1B IL6 TNF
13 12.38 CD40LG IL17A IL1B MPO TLR9 TNF
14
Show member pathways
12.3 IL17A IL1B IL6 TNF
15
Show member pathways
12.23 CD40LG HLA-DRB1 IL1B TNF
16
Show member pathways
12.15 IL1B IL6 TLR9 TNF
17
Show member pathways
12.11 IL17A IL1B IL6 TNF
18 12.08 HLA-DRB1 IL1B IL6 TLR9 TNF
19 11.96 IL1B IL6 TNF
20 11.95 IL6 MPO TNF
21 11.95 IL17A IL1B IL6 TNF
22 11.91 IL1B IL6 TNF
23 11.87 HLA-DRB1 IL1B IL6 TNF
24
Show member pathways
11.87 IL17A IL1B IL6 TLR9
25 11.86 IL1B IL6 TNF
26 11.85 IL1B IL6 TNF
27 11.84 CD40LG IL1B TNF
28
Show member pathways
11.78 CD40LG TNF TNFRSF10A
29 11.75 IL17A IL1B TNF
30 11.73 IL1B IL6 TNF
31 11.69 IL1B IL6 TLR9 TNF
32 11.64 IL1B IL6 TNF
33 11.64 CD40LG IL6 TLR9 TNF
34 11.58 IL1B IL6 TNF
35
Show member pathways
11.58 CD40LG IL1B IL6 TNF
36
Show member pathways
11.58 IL17A IL1B IL6 TLR9 TNF
37 11.52 IL1B IL6 TNF
38 11.51 IL6 MPO TNF
39 11.47 IL1B IL6 TNF
40 11.34 IL1B IL6 TNF
41 11.31 HLA-DRB1 IL17A IL1B IL6 TNF
42 11.28 IL1B IL6 TNF
43 11.21 IL1B IL6 TLR9 TNF
44 11.13 IL17A IL1B IL6 TNF
45 11.09 CD40LG IL17A IL1B IL6 TNF
46 11.05 IL1B TNF
47 11.05 IL6 TNF
48 11.03 HLA-DRB1 IL1B IL6 TNF
49 11.02 CRP IL6 TNF
50 10.9 IL1B MPO TNF

GO Terms for Central Nervous System Vasculitis

Cellular components related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CD40LG CRP IL17A IL1B IL6 MPO
2 lysosome GO:0005764 9.56 HLA-DRB1 IL1B MPO TLR9
3 extracellular space GO:0005615 9.56 CD40LG CRP IL17A IL1B IL6 MPO
4 external side of plasma membrane GO:0009897 9.02 CD40LG HLA-DRB1 IL17A IL6 TNF

Biological processes related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show all 34)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.85 CRP IL1B IL6 TLR9 TNF
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.83 CD40LG TNF TNFRSF10A
3 response to lipopolysaccharide GO:0032496 9.83 IL1B IL6 MPO TNFRSF10A
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.81 IL1B IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.79 CRP IL6 TNF
6 positive regulation of JNK cascade GO:0046330 9.77 IL1B TLR9 TNF
7 positive regulation of T cell proliferation GO:0042102 9.75 CD40LG IL1B IL6
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 IL1B IL6 TNF
9 positive regulation of interleukin-6 secretion GO:2000778 9.66 IL17A IL1B
10 positive regulation of osteoclast differentiation GO:0045672 9.66 IL17A TNF
11 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF
13 negative regulation of growth of symbiont in host GO:0044130 9.64 MPO TNF
14 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
16 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.62 IL1B TLR9
17 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
18 positive regulation of histone phosphorylation GO:0033129 9.61 CDK9 IL1B
19 positive regulation of interleukin-8 production GO:0032757 9.61 IL1B TLR9 TNF
20 regulation of establishment of endothelial barrier GO:1903140 9.58 IL1B TNF
21 positive regulation of NF-kappaB import into nucleus GO:0042346 9.58 IL1B TLR9 TNF
22 response to yeast GO:0001878 9.57 IL6 MPO
23 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.56 IL6 TNF
24 positive regulation of interleukin-6 production GO:0032755 9.56 IL1B IL6 TLR9 TNF
25 positive regulation of fever generation GO:0031622 9.55 IL1B TNF
26 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.55 CD40LG IL1B IL6 TLR9 TNF
27 regulation of immunoglobulin secretion GO:0051023 9.54 CD40LG TNF
28 positive regulation of chemokine production GO:0032722 9.54 IL6 TLR9 TNF
29 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
30 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
31 immune response GO:0006955 9.5 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
32 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IL1B TNF
33 inflammatory response GO:0006954 9.23 CD40LG CRP IL17A IL1B IL6 TLR9
34 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.08 CDK9 IL17A IL1B IL6 TLR9 TNF

Molecular functions related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CD40LG IL17A IL1B IL6 TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR9

Sources for Central Nervous System Vasculitis

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