CPM
MCID: CNT025
MIFTS: 42

Central Pontine Myelinolysis (CPM) malady

Neuronal diseases category

Summaries for Central Pontine Myelinolysis

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Sources:
42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Central pontine myelinolysis (cpm) is a neurological disorder that most frequently occurs when sodium deficiency is treated too rapidly.  the part of the brain called the pons is especially sensitive and too much sodium can damage nerve fibers.  initial signs and symptoms appear within two to three days and include a depressed level of awareness, difficulty speaking, and difficulty swallowing.  additional symptoms often occur in the next one to two weeks, including impaired thinking, weakness or paralysis in the arms and legs, stiffness, impaired sensation, and difficulty with coordination.  severe cpm can lead to coma, “locked-in” syndrome, and death. treatment is focused on safely restoring sodium levels and relieving symptoms. many affected people improve over weeks to months; however, some have permanent disability or develop new symptoms later on including behavioral or intellectual impairment or movement disorders like parkinsonism or tremor. last updated: 7/21/2011

MalaCards: Central Pontine Myelinolysis, also known as myelinolysis, central pontine, is related to diabetes mellitus and anorexia nervosa. An important gene associated with Central Pontine Myelinolysis is AVP (arginine vasopressin), and among its related pathways is Glial Cell Differentiation. The compounds ctla4-ig and methacholine have been mentioned in the context of this disorder. Affiliated tissues include brain, pons and liver.

NINDS:43 Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in sodium concentration is accompanied by the movement of small molecules and pulls water from brain cells. Through a mechanism that is only partly understood, the shift in water and brain molecules leads to the destruction of myelin, a substance that surrounds and protects nerve fibers. Nerve cells (neurons) can also be damaged. Certain areas of the brain are particularly susceptible to myelinolysis, especially the part of the brainstem called the

Wikipedia:63 Central pontine myelinolysis (CPM) is a neurological disease caused by severe damage of the myelin... more...

Aliases & Classifications for Central Pontine Myelinolysis

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

central pontine myelinolysis 8 42 43 10
myelinolysis, central pontine 60
myelinolysis central pontine 44
central pontine myelinosis 8
cpm 42


External Ids:

Disease Ontology8 DOID:636
MeSH34 D017590
SNOMED-CT56 6807001
NCIt39 C84623
ICD1025 G37.2

Related Diseases for Central Pontine Myelinolysis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Central Pontine Myelinolysis:



Diseases related to central pontine myelinolysis

Clinical Features for Central Pontine Myelinolysis

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Drugs & Therapeutics for Central Pontine Myelinolysis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Central Pontine Myelinolysis

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Anatomical Context for Central Pontine Myelinolysis

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32MalaCards
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MalaCards organs/tissues related to Central Pontine Myelinolysis:

32
Brain, Pons, Liver, Bone, Lung, Bone marrow, Endothelial, Pituitary

Animal Models for Central Pontine Myelinolysis or affiliated genes

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Publications for Central Pontine Myelinolysis

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50PubMed
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Articles related to Central Pontine Myelinolysis:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Central pontine myelinolysis. (23760391)
2013
2
Central pontine myelinolysis following acute hypoglycemia. (23948485)
2013
3
Asymptomatic central pontine myelinolysis: a case report. (23185169)
2012
4
Central pontine myelinolysis without hyponatraemia. (22441074)
2012
5
Central pontine myelinolysis: a lesson in humility*. (22343870)
2012
6
Central pontine myelinolysis: a case report and clinical-pathological review. (22023701)
2012
7
Central pontine and extrapontine myelinolysis in children: a review of 76 patients. (22647485)
2012
8
Complete clinical recovery of a central pontine and extrapontine myelinolysis delayed onset in a child with acute myeloblastic leukemia. (21311430)
2011
9
Central pontine myelinolysis secondary to hypokalaemic nephrogenic diabetes insipidus. (19940203)
2010
10
Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication. (19786335)
2010
11
Central pontine myelinolysis in a pediatric head injury patient. (20516740)
2010
12
Idiopathic central pontine myelinolysis in an eunatremic patient with AIDS. (19564726)
2009
13
Central pontine myelinolysis after liver transplantation: is sodium the only villain? Case report. (19488548)
2009
14
Central pontine myelinolysis. (19033724)
2009
15
Central pontine myelinolysis in a patient with hyperosmolar hyperglycemia and consistently normal serum sodium. (19565358)
2009
16
Central pontine and extrapontine myelinolysis after alcohol withdrawal. (18678596)
2008
17
A study of the pathogenesis and prevention of central pontine myelinolysis in a rat model. (16866020)
2006
18
Lower urinary tract dysfunction in central pontine myelinolysis: possible contribution of the pontine micturition centre. (16190922)
2005
19
Central pontine myelinolysis associated with hypokalaemia in anorexia nervosa. (15026526)
2004
20
Central pontine myelinolysis associated with hypokalaemia in anorexia nervosa. (12588925)
2003
21
Central pontine myelinolysis temporally related to hypophosphataemia. (12754365)
2003
22
Paroxysmal kinesigenic dyskinesia associated with central pontine myelinolysis. (14644002)
2003
23
Evidence for a role for apoptosis in central pontine myelinolysis. (12012091)
2002
24
Central pontine myelinolysis: sequele of hyponatremia during transcervical resection of endometrium. (12139553)
2002
25
Hepatic encephalopathy associated with central pontine myelinolysis. (12583486)
2002
26
Central pontine myelinolysis in a patient with anorexia nervosa. (11746309)
2001
27
Central pontine myelinolysis--a rare manifestation of CNS Sjogren's syndrome. (10981655)
2000
28
Central pontine myelinolysis in AIDS. (9829820)
1998
29
Central pontine myelinolysis causes bilateral loss of deep sensitivity and pseudochoreoathetosis. (9771804)
1998
30
Extra and central pontine myelinolysis in a child with adrenal insufficiency. (9367298)
1997
31
Central pontine myelinolysis: CT technique. (9265691)
1997
32
Central pontine myelinolysis at autopsy; a twelve year retrospective analysis. (8902733)
1996
33
Central pontine myelinolysis secondary to frequent and rapid shifts in plasma glucose in a diabetic haemodialysis patient. (8396751)
1993
34
Dystonia in central pontine myelinolysis without evidence of extrapontine myelinolysis. (8229036)
1993
35
Hodgkin's disease associated with central pontine myelinolysis. (7682285)
1993
36
Movement disorders as sequelae of central pontine myelinolysis: report of three cases. (1584236)
1992
37
Delayed-onset dystonia following recovery from central pontine myelinolysis. (1362667)
1992
38
Central pontine myelinolysis in a patient with AIDS. (1640250)
1992
39
Adaptive decreases in amino acids (taurine in particular), creatine, and electrolytes prevent cerebral edema in chronically hyponatremic mice: rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain. (3505340)
1987
40
Extensive extrapontine and central pontine myelinolysis associated with correction of profound hyponatraemia. (3574598)
1987
41
MR imaging of central pontine myelinolysis. (3597904)
1987
42
Central pontine myelinolysis complicating hyponatraemia. (3614073)
1987
43
Central pontine myelinolysis--a preventable condition. Two case reports and review of the literature. (3762141)
1986
44
A case of central pontine myelinolysis confirmed by computed tomography. (3579768)
1986
45
Central pontine myelinolysis following saline treatment of a diabetic rat for dehydration. (6643752)
1983
46
Central pontine myelinolysis following hyponatremia, demonstrated by computerized tomography. (518040)
1979
47
Brain stem auditory-evoked responses in suspected central pontine myelinolysis. (973811)
1976
48
Pathogenesis of central pontine myelinolysis. A clinical and pathological description of three cases. (4927761)
1971
49
Central pontine myelinolysis and cirrhosis of the liver. A report of four cases. (5912488)
1966
50
CENTRAL PONTINE MYELINOLYSIS. A REPORT OF TWO CASES. (14048191)
1963

Genetic Variations for Central Pontine Myelinolysis

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Expression for genes affiliated with Central Pontine Myelinolysis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Pontine Myelinolysis

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Pathways for genes affiliated with Central Pontine Myelinolysis

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37NCBI BioSystems Database
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Pathways related to Central Pontine Myelinolysis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MAG, MBP

Compounds for genes affiliated with Central Pontine Myelinolysis

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Central Pontine Myelinolysis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1ctla4-ig449.8MBP, IL2RB
2methacholine44 1110.7MBP, IL2RB
32,3-cyclic nucleotide449.6MBP, MAG
4sulfatide449.6MAG, MBP
5phosphothreonine449.6MAG, MBP
6phosphoserine44 2410.5MBP, MAG
7melatonin44 59 28 11 2413.3IL2RB, AVP
8norepinephrine44 11 2411.3AVP, IL2RB, MBP
9ganglioside449.3MBP, MAG
10creatinine449.2MBP, IL2RB, AVP
11vanadate449.2MAG, MBP
12ivig449.2IL2RB, MAG, MBP
13phosphotyrosine449.1MAG, IL2RB, MBP
14thymidine44 2410.0IL2RB, MAG, MBP
15aspartate448.9MBP, MAG, IL2RB
1612-o-tetradecanoylphorbol 13-acetate448.9FOXM1, IL2RB, MBP
17threonine448.8MBP, MAG, IL2RB, AVP
18alanine448.8IL2RB, AVP, MAG, MBP
19serine448.5MAG, AVP, MBP, IL2RB

GO Terms for genes affiliated with Central Pontine Myelinolysis

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16Gene Ontology
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Biological processes related to Central Pontine Myelinolysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:0507719.3MAG, MBP

Products for genes affiliated with Central Pontine Myelinolysis

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Sources for Central Pontine Myelinolysis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet