CPM
MCID: CNT025
MIFTS: 41

Central Pontine Myelinolysis (CPM) malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Central Pontine Myelinolysis

Aliases & Descriptions for Central Pontine Myelinolysis:

Name: Central Pontine Myelinolysis 12 50 51 14
Myelinolysis, Central Pontine 42 69
Osmotic Demyelination Syndrome 12
Myelinolysis Central Pontine 52
Cpm 50

Classifications:



External Ids:

Disease Ontology 12 DOID:636
ICD10 33 G37.2
MeSH 42 D017590
NCIt 47 C84623
SNOMED-CT 64 6807001
UMLS 69 C0206083

Summaries for Central Pontine Myelinolysis

NIH Rare Diseases : 50 central pontine myelinolysis (cpm) is a neurological disorder that most frequently occurs when sodium deficiency is treated too rapidly.  the part of the brain called the pons is especially sensitive and too much sodium can damage nerve fibers.  initial signs and symptoms appear within two to three days and include a depressed level of awareness, difficulty speaking, and difficulty swallowing.  additional symptoms often occur in the next one to two weeks, including impaired thinking, weakness or paralysis in the arms and legs, stiffness, impaired sensation, and difficulty with coordination.  severe cpm can lead to coma, “locked-in” syndrome, and death. treatment is focused on safely restoring sodium levels and relieving symptoms. many affected people improve over weeks to months; however, some have permanent disability or develop new symptoms later on including behavioral or intellectual impairment or movement disorders like parkinsonism or tremor. last updated: 7/21/2011

MalaCards based summary : Central Pontine Myelinolysis, also known as myelinolysis, central pontine, is related to extrapontine myelinolysis and atypical lipomatous tumor, and has symptoms including acute paralysis, dysphagia and dysarthria. An important gene associated with Central Pontine Myelinolysis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Bile secretion and Spinal Cord Injury. Affiliated tissues include pons, brain and liver, and related phenotypes are behavior/neurological and hearing/vestibular/ear

Disease Ontology : 12 A demyelination disease that is characterized by severe damage to the myelin sheath of the pons' nerve cells and has symptom acute paralysis, has symptom dysphagia, and has symptom dysarthria.

NINDS : 51 Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in sodium concentration is accompanied by the movement of small molecules and pulls water from brain cells. Through a mechanism that is only partly understood, the shift in water and brain molecules leads to the destruction of myelin, a substance that surrounds and protects nerve fibers. Nerve cells (neurons) can also be damaged. Certain areas of the brain are particularly susceptible to myelinolysis, especially the part of the brain stem called the pons.  Some individuals will also have damage in other areas of the brain, which is called extrapontine myelinolysis (EPM). Experts estimate that 10 percent of those with CPM will also have areas of EPM.

Wikipedia : 71 Central pontine myelinolysis (CPM), also known as osmotic demyelination syndrome or central pontine... more...

Related Diseases for Central Pontine Myelinolysis

Diseases related to Central Pontine Myelinolysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Related Disease Score Top Affiliating Genes
1 extrapontine myelinolysis 11.5
2 atypical lipomatous tumor 11.0
3 encephalopathy 10.3
4 anorexia nervosa 10.2
5 lymphoma 10.1
6 dystonia 10.1
7 ataxia 10.1
8 cerebellar liponeurocytoma 10.1 BCL2 MBP
9 crest syndrome 10.1 AQP4 MBP
10 trichomalacia 10.1 AQP4 MBP
11 gastric dilatation 10.1 AQP4 MBP
12 clear cell adenoma 10.1 AQP4 MBP
13 ehlers-danlos syndrome, kyphoscoliotic form 10.1 AQP1 AQP4
14 superior vena cava syndrome 10.0 AQP1 AQP4
15 cerebellar ataxia 10.0
16 hepatitis 10.0
17 leukemia 10.0
18 hypophosphatemia 10.0
19 cerebritis 10.0
20 myoclonus 10.0
21 tremor 10.0
22 urea cycle disorder 10.0 AQP4 MBP
23 lung adenoid cystic carcinoma 10.0 AQP1 BCL2
24 leiomyoma 10.0 AQP1 AQP4
25 schwannoma of twelfth cranial nerve 10.0 AQP4 MBP
26 rickets due to defect in vitamin d 25-hydroxylation 10.0 MAG MBP
27 urethral gland abscess 10.0 AQP1 AQP4
28 nerve fibre bundle defect 10.0 AQP4 MBP
29 uterine corpus cancer 10.0 AQP1 AQP4
30 lice infestation 10.0 MAG MBP
31 basal cell carcinoma 4 10.0 AQP1 AQP4
32 mohr-tranebjaerg syndrome 10.0 MAG MBP
33 korsakoff's amnesic syndrome 10.0 MAG MBP
34 alcohol dependence 10.0
35 wilson disease 10.0
36 b-cell lymphomas 10.0
37 diffuse large b-cell lymphoma 10.0
38 locked-in syndrome 10.0
39 quadriplegia 10.0
40 sjogren's syndrome 10.0
41 wernicke encephalopathy 10.0
42 pancreatitis 10.0
43 hypoglycemia 10.0
44 chondrocalcinosis 10.0 AQP1 BCL2
45 histiocytoid hemangioma 9.9 AQP1 AQP4
46 ovarian disease 9.9 AQP1 AQP4 MBP
47 niemann-pick disease 9.9 AQP1 AQP4 MBP
48 white piedra 9.9 MAG MBP
49 neonatal jaundice 9.8 AQP4 MBP
50 megakaryocytic leukemia 9.8 BCL2 MAG MBP

Graphical network of the top 20 diseases related to Central Pontine Myelinolysis:



Diseases related to Central Pontine Myelinolysis

Symptoms & Phenotypes for Central Pontine Myelinolysis

Symptoms:

12
  • acute paralysis
  • dysphagia
  • dysarthria

MGI Mouse Phenotypes related to Central Pontine Myelinolysis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.77 AQP1 AQP4 BCL2 MAG MBP
2 hearing/vestibular/ear MP:0005377 9.72 MBP AQP1 AQP4 BCL2 MAG
3 hematopoietic system MP:0005397 9.65 AQP1 AQP4 BCL2 MAG MBP
4 homeostasis/metabolism MP:0005376 9.55 AQP1 AQP4 BCL2 MAG MBP
5 nervous system MP:0003631 9.35 AQP1 AQP4 BCL2 MAG MBP
6 vision/eye MP:0005391 8.92 AQP1 AQP4 BCL2 MBP

Drugs & Therapeutics for Central Pontine Myelinolysis

Search Clinical Trials , NIH Clinical Center for Central Pontine Myelinolysis

Cochrane evidence based reviews: myelinolysis, central pontine

Genetic Tests for Central Pontine Myelinolysis

Anatomical Context for Central Pontine Myelinolysis

MalaCards organs/tissues related to Central Pontine Myelinolysis:

39
Pons, Brain, Liver, B Cells, Lung, Endothelial, Pituitary

Publications for Central Pontine Myelinolysis

Articles related to Central Pontine Myelinolysis:

(show top 50) (show all 375)
id Title Authors Year
1
Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical Horizon. ( 27610136 )
2016
2
Poster 282 Functional Gains after Diagnosis of Central Pontine Myelinolysis due to Hypophosphatemia in a Leukemia Patient on an Acute Inpatient Rehabilitation Unit: A Case Report. ( 27673041 )
2016
3
IMAGES IN CLINICAL MEDICINE. Central Pontine Myelinolysis. ( 26886548 )
2016
4
Central pontine myelinolysis during pregnancy: Pathogenesis, diagnosis and management. ( 27922286 )
2016
5
Striking Central Pontine Myelinolysis in a Patient With Alcohol Dependence Syndrome Without Hyponatremia. ( 26720620 )
2016
6
Hypertensive brainstem encephalopathy mimicking central pontine myelinolysis: a potential pitfall. ( 26935223 )
2016
7
Central pontine myelinolysis caused by hypernatremia. ( 27772775 )
2016
8
Psychiatric symptoms and limb tremors associated with central pontine myelinolysis: A case of alcoholism without hyponatremia. ( 27882183 )
2016
9
Asymptomatic central pontine myelinolysis without hyponatriemia in diffuse large B cell lymphoma. ( 27488303 )
2016
10
Central pontine myelinolysis in Sjogren's syndrome with hypokalemia. ( 26929036 )
2016
11
Central pontine myelinolysis secondary to hyperglycaemia. ( 27407176 )
2016
12
Osmotic myelinolysis: Does extrapontine myelinolysis precede central pontine myelinolysis? Report of two cases and review of literature. ( 25969642 )
2015
13
Urinary incontinence a first presentation of central pontine myelinolysis: a case report. ( 26209689 )
2015
14
The owl and the monkey - The varied faces of pons in central pontine myelinolysis. ( 26588651 )
2015
15
Diffuse large B-cell lymphoma presenting with central pontine myelinolysis: a case report. ( 26044457 )
2015
16
Central pontine myelinolysis-induced mania: A case study. ( 25732324 )
2015
17
A Case of Central Pontine Myelinolysis Caused by Hypophosphatemia Secondary to Refeeding Syndrome. ( 26557081 )
2015
18
A Rare Case of Central Pontine Myelinolysis in Overcorrection of Hyponatremia with Total Parenteral Nutrition in Pregnancy. ( 26798530 )
2015
19
Central Pontine Myelinolysis with Minimal Hyponatremia in the Setting of AIDS. ( 26605097 )
2015
20
Central pontine myelinolysis presenting as isolated sixth nerve palsy in third trimester of pregnancy. ( 25745319 )
2015
21
Central pontine myelinolysis in a case of alcohol dependence syndrome. ( 27212829 )
2015
22
Central pontine myelinolysis: a rare presentation secondary to hyperglycaemia. ( 25917480 )
2015
23
Central pontine myelinolysis. ( 25395281 )
2014
24
Plasma exchange successfully treats central pontine myelinolysis after acute hypernatremia from intravenous sodium bicarbonate therapy. ( 24708786 )
2014
25
Central pontine myelinolysis: electrolytes and beyond. ( 24682140 )
2014
26
Locked-in Syndrome due to Central Pontine Myelinolysis: Case Report. ( 25379502 )
2014
27
Osmotic demyelination syndrome: central pontine myelinolysis and extrapontine myelinolysis. ( 24745890 )
2014
28
Central pontine myelinolysis following pediatric living donor liver transplantation: a case report and review of literature. ( 24725019 )
2014
29
Central pontine myelinolysis without electrolyte disorder, alcoholism or denutrition. ( 24906708 )
2014
30
Central pontine myelinolysis associated with Wilson disease in a 7-year-old child. ( 23704419 )
2013
31
Wernicke's encephalopathy and central pontine myelinolysis in hyperemesis gravidarum. ( 23546346 )
2013
32
Central Pontine Myelinolysis Presenting With Tremor in a Child With Celiac Disease. ( 23390116 )
2013
33
Central pontine myelinolysis in advanced HIV infection with tuberculosis and multicentric Castleman's disease. ( 23970776 )
2013
34
Central pontine myelinolysis in the hyperosmolar hyperglycaemic state. ( 22922267 )
2013
35
Can central pontine myelinolysis be prevented through non-rapid serum sodium correction? ( 23065440 )
2013
36
Central pontine myelinolysis. ( 23760391 )
2013
37
Central pontine myelinolysis with meticulous correction of hyponatraemia in chronic alcoholics. ( 23813514 )
2013
38
Central pontine myelinolysis. ( 23608854 )
2013
39
Central pontine myelinolysis in a patient with persistent mild hypernatremia following cadaver donor liver transplantation. ( 23904947 )
2013
40
Evidence of aquaporin involvement in human central pontine myelinolysis. ( 24252214 )
2013
41
Central pontine myelinolysis in a chronic alcoholic patient with hyperglycemic hyperosmotic state. ( 24030096 )
2013
42
Central pontine myelinolysis following acute hypoglycemia. ( 23948485 )
2013
43
Recovery of locked-in syndrome in central pontine myelinolysis. ( 23826473 )
2013
44
Central pontine myelinolysis in a chronic alcoholic: a clinical and brain magnetic resonance imaging follow-up. ( 24069831 )
2013
45
Brainstem somatosensory and auditory evoked responses in central pontine myelinolysis. ( 23975561 )
2013
46
Central pontine myelinolysis in a patient with non-Hodgkin lymphoma. ( 23384152 )
2013
47
Central pontine myelinolysis: a case report and clinical-pathological review. ( 22023701 )
2012
48
Asymptomatic central pontine myelinolysis: a case report. ( 23185169 )
2012
49
Pontine hyperperfusion during recovery from central pontine myelinolysis. ( 22466847 )
2012
50
Rare association of central pontine myelinolysis with infantile tremor syndrome. ( 22412274 )
2012

Variations for Central Pontine Myelinolysis

Expression for Central Pontine Myelinolysis

Search GEO for disease gene expression data for Central Pontine Myelinolysis.

Pathways for Central Pontine Myelinolysis

Pathways related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.11 AQP1 AQP4
2 11 AQP1 AQP4 MAG MBP
3 10.95 MAG MBP
4 9.86 MAG MBP

GO Terms for Central Pontine Myelinolysis

Cellular components related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.8 BCL2 MAG MBP

Biological processes related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.4 BCL2 MAG
2 cellular response to hypoxia GO:0071456 9.37 AQP1 BCL2
3 response to toxic substance GO:0009636 9.32 BCL2 MBP
4 cellular response to mechanical stimulus GO:0071260 9.26 AQP1 MAG
5 renal water homeostasis GO:0003091 9.16 AQP1 AQP4
6 water transport GO:0006833 8.96 AQP1 AQP4
7 multicellular organismal water homeostasis GO:0050891 8.62 AQP1 AQP4

Molecular functions related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.16 BCL2 MBP
2 water channel activity GO:0015250 8.96 AQP1 AQP4
3 water transmembrane transporter activity GO:0005372 8.62 AQP1 AQP4

Sources for Central Pontine Myelinolysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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