MCID: CNT025
MIFTS: 39

Central Pontine Myelinolysis malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Central Pontine Myelinolysis

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Central Pontine Myelinolysis, Aliases & Descriptions:

Name: Central Pontine Myelinolysis 9 41 42 11
Myelinolysis, Central Pontine 60
Myelinolysis Central Pontine 43
 
Central Pontine Myelinosis 9
Cpm 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:636
NCIt38 C84623
SNOMED-CT55 6807001
MeSH33 D017590
ICD1025 G37.2

Summaries for Central Pontine Myelinolysis

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NIH Rare Diseases:41 Central pontine myelinolysis (cpm) is a neurological disorder that most frequently occurs when sodium deficiency is treated too rapidly.  the part of the brain called the pons is especially sensitive and too much sodium can damage nerve fibers.  initial signs and symptoms appear within two to three days and include a depressed level of awareness, difficulty speaking, and difficulty swallowing.  additional symptoms often occur in the next one to two weeks, including impaired thinking, weakness or paralysis in the arms and legs, stiffness, impaired sensation, and difficulty with coordination.  severe cpm can lead to coma, “locked-in” syndrome, and death. treatment is focused on safely restoring sodium levels and relieving symptoms. many affected people improve over weeks to months; however, some have permanent disability or develop new symptoms later on including behavioral or intellectual impairment or movement disorders like parkinsonism or tremor. last updated: 7/21/2011

MalaCards based summary: Central Pontine Myelinolysis, also known as myelinolysis, central pontine, is related to leukemia and extrapontine myelinolysis. An important gene associated with Central Pontine Myelinolysis is FLVCR2 (feline leukemia virus subgroup C cellular receptor family, member 2), and among its related pathways are Glial Cell Differentiation and Spinal Cord Injury. The compounds ctla4-ig and methacholine have been mentioned in the context of this disorder. Affiliated tissues include brain, pons and liver.

NINDS:42 Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in sodium concentration is accompanied by the movement of small molecules and pulls water from brain cells. Through a mechanism that is only partly understood, the shift in water and brain molecules leads to the destruction of myelin, a substance that surrounds and protects nerve fibers. Nerve cells (neurons) can also be damaged. Certain areas of the brain are particularly susceptible to myelinolysis, especially the part of the brainstem called the

Wikipedia:63 Central pontine myelinolysis (CPM), also known as Osmotic demyelination syndrome, is a neurological... more...

Related Diseases for Central Pontine Myelinolysis

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Graphical network of the top 20 diseases related to Central Pontine Myelinolysis:



Diseases related to central pontine myelinolysis

Symptoms for Central Pontine Myelinolysis

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Drugs & Therapeutics for Central Pontine Myelinolysis

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Drug clinical trials:

Search ClinicalTrials for Central Pontine Myelinolysis

Search NIH Clinical Center for Central Pontine Myelinolysis

Genetic Tests for Central Pontine Myelinolysis

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Anatomical Context for Central Pontine Myelinolysis

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MalaCards organs/tissues related to Central Pontine Myelinolysis:

31
Brain, Pons, Liver, Bone marrow, Bone, Endothelial, Pituitary

Animal Models for Central Pontine Myelinolysis or affiliated genes

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Publications for Central Pontine Myelinolysis

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Articles related to Central Pontine Myelinolysis:

(show top 50)    (show all 352)
idTitleAuthorsYear
1
Osmotic demyelination syndrome: central pontine myelinolysis and extrapontine myelinolysis. (24745890)
2014
2
Central pontine myelinolysis in the hyperosmolar hyperglycaemic state. (22922267)
2013
3
Rare association of central pontine myelinolysis with infantile tremor syndrome. (22412274)
2012
4
Corticospinal tract and pontocerebellar fiber of central pontine myelinolysis. (23342326)
2012
5
Plasmapheresis and Intravenous Immune Globulin Improve Neurologic Outcome of Central Pontine Myelinolysis Occurring Post Orthotopic Liver Transplant (February). (21304032)
2011
6
Central pontine myelinolysis as a cause of bilateral vocal fold immobility due to hyponatremia. (21271583)
2011
7
Central pontine myelinolysis secondary to hypokalaemic nephrogenic diabetes insipidus. (19940203)
2010
8
Idiopathic central pontine myelinolysis in an eunatremic patient with AIDS. (19564726)
2009
9
Central pontine myelinolysis despite slow sodium rise in a case of severe community-acquired hyponatraemia. (19157357)
2009
10
The corticobasal syndrome triggered by central pontine myelinolysis. (16420397)
2006
11
Central pontine myelinolysis, an update. (16687066)
2006
12
Central pontine myelinolysis associated with hypokalaemia in anorexia nervosa. (15026526)
2004
13
Efficacy of clozapine in a non-schizophrenic patient with psychogenic polydipsia and central pontine myelinolysis. (12404683)
2002
14
Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity. (12630660)
2002
15
Central pontine myelinolysis: association with parenteral magnesium administration. (10870372)
2000
16
Severe hyponatraemia secondary to beer potomania complicated by central pontine myelinolysis. (10622059)
1998
17
Central pontine myelinolysis in a normonatremic child. (9255014)
1997
18
Central pontine myelinolysis in a previously healthy 4-year-old child with acute rotavirus gastroenteritis. (9113955)
1997
19
Extra and central pontine myelinolysis in a child with adrenal insufficiency. (9367298)
1997
20
Persistence of MRI changes in central pontine myelinolysis. (8971102)
1996
21
A chronic glue sniffer with hyperchloraemia metabolic acidosis, rhabdomyolysis, irreversible quadriplegia, central pontine myelinolysis, and hypothyroidism. (8918637)
1996
22
A case of central pontine myelinolysis after surgical removal of a pituitary tumor. (8677485)
1996
23
Central pontine myelinolysis: report of an asymptomatic case. (7727208)
1995
24
Central pontine myelinolysis secondary to frequent and rapid shifts in plasma glucose in a diabetic haemodialysis patient. (8396751)
1993
25
Movement disorders as sequelae of central pontine myelinolysis: report of three cases. (1584236)
1992
26
Central pontine myelinolysis and pontine lesions after rapid correction of hyponatremia: a prospective magnetic resonance imaging study. (2301929)
1990
27
Magnetic resonance imaging in central pontine myelinolysis. (2277006)
1990
28
Central pontine myelinolysis after liver transplantation. (2648187)
1989
29
Central pontine myelinolysis and its imitators: MR findings. (3406409)
1988
30
Acquired focal dystonia following recovery from central pontine myelinolysis. (3225594)
1988
31
Central pontine myelinolysis: report of a case with distinctive appearance on MR imaging. (3111231)
1987
32
Central pontine myelinolysis: diagnosis by computed tomography, magnetic resonance and evoked potentials. (3804711)
1986
33
Distribution of demyelinating lesions in pontine and extrapontine myelinolysis--three autopsy cases including one case devoid of central pontine myelinolysis. (3962604)
1986
34
Central pontine myelinolysis and abnormalities in serum sodium. (3815936)
1986
35
Central pontine myelinolysis accompanied by multifocal pseudocalcifications. (4083010)
1985
36
Changing concepts in treatment of severe symptomatic hyponatremia. Rapid correction and possible relation to central pontine myelinolysis. (4014266)
1985
37
Central pontine myelinolysis with widespread extrapontine lesions: a report of two cases. (6568941)
1984
38
Recovery from probably central pontine myelinolysis associated with Addison's disease. (6824444)
1983
39
Central pontine myelinolysis: correlation between CT and electrophysiologic data. (6410789)
1983
40
Central pontine myelinolysis. (7329883)
1981
41
Demyelination of the lateral geniculate nucleus in central pontine myelinolysis. (7235634)
1981
42
Central pontine myelinolysis following hyponatremia, demonstrated by computerized tomography. (518040)
1979
43
Central pontine myelinolysis. A clinical reappraisal. (843256)
1977
44
Central pontine myelinolysis. (4792161)
1973
45
Central pontine myelinolysis and Rosenthal fibers of the brainstem. Association with emaciation and prolonged intravenous hyperalimentation. (4117115)
1972
46
Central pontine myelinolysis in childhood. (5110124)
1971
47
Subacute necrotizing encephalomyelopathy. Its relationship to central pontine myelinolysis. (5478948)
1970
48
CENTRAL PONTINE MYELINOLYSIS. (14200786)
1964
49
CENTRAL PONTINE MYELINOLYSIS. (A CASE REPORT). (14191012)
1964
50
Central pontine myelinolysis. (13685966)
1960

Variations for Central Pontine Myelinolysis

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Expression for genes affiliated with Central Pontine Myelinolysis

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Search GEO for disease gene expression data for Central Pontine Myelinolysis.

Pathways for genes affiliated with Central Pontine Myelinolysis

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Compounds for genes affiliated with Central Pontine Myelinolysis

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Compounds related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

(show all 20)
idCompoundScoreTop Affiliating Genes
1ctla4-ig439.8MBP, IL2RB
2methacholine43 49 1211.8MBP, IL2RB
32,3-cyclic nucleotide439.7MAG, MBP
4prednisolone43 28 1211.6MBP, IL2RB
5sulfatide439.6MAG, MBP
6phosphothreonine439.6MBP, MAG
7phosphoserine43 2410.6MBP, MAG
8ganglioside439.5MBP, MAG
9vanadate439.5MAG, MBP
10cyclophosphamide43 49 1211.5MBP, IL2RB
11okadaic acid43 5910.5MBP, IL2RB
12ivig439.2MBP, MAG, IL2RB
13phosphatidylserine43 28 1211.2MBP, IL2RB
14phosphotyrosine439.2MBP, MAG, IL2RB
15thymidine43 2410.1IL2RB, MAG, MBP
16aspartate439.1IL2RB, MAG, MBP
17threonine439.0MBP, MAG, IL2RB
1812-o-tetradecanoylphorbol 13-acetate439.0MBP, IL2RB, FOXM1
19alanine438.9IL2RB, MAG, MBP
20retinoic acid43 249.6FOXM1, IL2RB, MBP

GO Terms for genes affiliated with Central Pontine Myelinolysis

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Biological processes related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:00507719.3MBP, MAG
2substantia nigra developmentGO:00217629.2MBP, MAG
3G2/M transition of mitotic cell cycleGO:00000869.1FOXM1, LIN37
4regulation of cell cycleGO:00517268.8FOXM1, LIN37

Products for genes affiliated with Central Pontine Myelinolysis

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Sources for Central Pontine Myelinolysis

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