CPM
MCID: CNT025
MIFTS: 40

Central Pontine Myelinolysis (CPM) malady

Neuronal category

Summaries for Central Pontine Myelinolysis

Sources:
43NIH Rare Diseases, 44NINDS, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Central pontine myelinolysis (cpm) is a neurological disorder that most frequently occurs when sodium deficiency is treated too rapidly.  the part of the brain called the pons is especially sensitive and too much sodium can damage nerve fibers.  initial signs and symptoms appear within two to three days and include a depressed level of awareness, difficulty speaking, and difficulty swallowing.  additional symptoms often occur in the next one to two weeks, including impaired thinking, weakness or paralysis in the arms and legs, stiffness, impaired sensation, and difficulty with coordination.  severe cpm can lead to coma, “locked-in” syndrome, and death. treatment is focused on safely restoring sodium levels and relieving symptoms. many affected people improve over weeks to months; however, some have permanent disability or develop new symptoms later on including behavioral or intellectual impairment or movement disorders like parkinsonism or tremor. last updated: 7/21/2011

MalaCards: Central Pontine Myelinolysis, also known as myelinolysis, central pontine, is related to extrapontine myelinolysis and wernicke encephalopathy. An important gene associated with Central Pontine Myelinolysis is AVP (arginine vasopressin), and among its related pathways is Glial Cell Differentiation. The compounds ctla4-ig and methacholine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung.

NINDS:44 Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in sodium concentration is accompanied by the movement of small molecules and pulls water from brain cells. Through a mechanism that is only partly understood, the shift in water and brain molecules leads to the destruction of myelin, a substance that surrounds and protects nerve fibers. Nerve cells (neurons) can also be damaged. Certain areas of the brain are particularly susceptible to myelinolysis, especially the part of the brainstem called the

Wikipedia:64 Central pontine myelinolysis (CPM) is a neurological disease caused by severe damage of the myelin... more...

Aliases & Classifications for Central Pontine Myelinolysis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

central pontine myelinolysis 8 43 44 10
myelinolysis, central pontine 61
myelinolysis central pontine 45
central pontine myelinosis 8
cpm 43


External Ids:

Disease Ontology8 DOID:636
MeSH35 D017590
SNOMED-CT57 6807001
NCIt40 C84623
ICD1025 G37.2

Related Diseases for Central Pontine Myelinolysis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Central Pontine Myelinolysis:



Diseases related to central pontine myelinolysis

Clinical Features for Central Pontine Myelinolysis

Drugs & Therapeutics for Central Pontine Myelinolysis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Central Pontine Myelinolysis

Genetic Tests for Central Pontine Myelinolysis

Anatomical Context for Central Pontine Myelinolysis

Sources:
33MalaCards
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MalaCards organs/tissues related to Central Pontine Myelinolysis:

33
Liver, Brain, Lung, Bone marrow, Endothelial, Pons, Pituitary

Animal Models for Central Pontine Myelinolysis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Central Pontine Myelinolysis

Sources:
51PubMed
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Articles related to Central Pontine Myelinolysis:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Central pontine and extra-pontine myelinolysis after correction of severe hypoglycemia. (23728716)
2013
2
Central pontine myelinolysis in a chronic alcoholic: a clinical and brain magnetic resonance imaging follow-up. (24069831)
2013
3
Identifying Risk Factors for Central Pontine and Extrapontine Myelinolysis After Liver Transplantation: A Case-Control Study. (24233816)
2013
4
Brainstem somatosensory and auditory evoked responses in central pontine myelinolysis. (23975561)
2013
5
Wernicke's encephalopathy and central pontine myelinolysis in hyperemesis gravidarum. (23546346)
2013
6
Central pontine and extrapontine myelinolysis associated with acute hepatic dysfunction. (22080394)
2012
7
Acute psychosis with a favorable outcome as a complication of central pontine/extrapontine myelinolysis in a middle aged man. (23372330)
2012
8
Central pontine and extrapontine myelinolysis: a rare and fatal complication after liver transplantation. (21839243)
2011
9
A good prognosis of central pontine myelinolysis in a type II diabetic patient. (22065007)
2011
10
Central pontine myelinolysis. (20624565)
2010
11
A case of late adult-onset dentatorubral-pallidoluysian atrophy mimicking central pontine myelinolysis. (19390768)
2009
12
Antidepressants, thiazide diuretics and alcoholism: central pontine myelinolysis waiting to happen? (19451878)
2009
13
Possible causes of central pontine myelinolysis after liver transplantation. (15300900)
2004
14
Serial magnetic resonance imaging of central pontine myelinolysis. (12089721)
2002
15
Benign course of central pontine myelinolysis in a patient with anorexia nervosa. (12213614)
2002
16
Central pontine myelinolysis. (11803185)
2002
17
Subclinical central pontine myelinolysis following liver transplantation. (11934516)
2002
18
Central pontine myelinolysis: association with parenteral magnesium administration. (10870372)
2000
19
Central pontine and extrapontine myelinolysis presenting with parkinsonism in a patient with cystic fibrosis. (10348485)
1999
20
Outcome of central pontine and extrapontine myelinolysis (n = 44). (10460448)
1999
21
Severe hyponatraemia secondary to beer potomania complicated by central pontine myelinolysis. (10622059)
1998
22
Central pontine myelinolysis in a patient with classic heat stroke. (9267966)
1997
23
A chronic glue sniffer with hyperchloraemia metabolic acidosis, rhabdomyolysis, irreversible quadriplegia, central pontine myelinolysis, and hypothyroidism. (8918637)
1996
24
Central pontine myelinolysis: report of an asymptomatic case. (7727208)
1995
25
Idiopathic hypereosinophilic syndrome with a radiologic pattern of central pontine myelinolysis. (7628500)
1995
26
Central pontine myelinolysis: a multidisciplinary approach to care. (8195648)
1994
27
Central pontine myelinolysis after correction of chronic hyponatraemia. (8100973)
1993
28
Correction of hyponatremia and development of central pontine myelinolysis. (8498405)
1993
29
Central pontine myelinolysis: report of two occurrences after cisplatin-containing chemotherapy for nasopharyngeal carcinoma. (8305365)
1993
30
Magnetic resonance imaging of extrapontine lesions in central pontine myelinolysis. (1400147)
1992
31
Central pontine myelinolysis in liver transplantation. (1752981)
1991
32
Central pontine myelinolysis and changes in serum sodium. (1971908)
1990
33
Thalamic extrapontine lesions in central pontine myelinolysis. (2124066)
1990
34
Gd-DTPA enhancement in MR imaging of central pontine myelinolysis. (2505569)
1989
35
Pathologic crying as a prominent behavioral manifestation of central pontine myelinolysis. (3415524)
1988
36
Autopsy validation of MRI in central pontine myelinolysis. (3386813)
1988
37
MR demonstration of mesencephalic lesions in osmotic demyelination syndrome (central pontine myelinolysis). (3431707)
1987
38
Neurological complications associated with parenteral treatment: central pontine myelinolysis and Wernicke's encephalopathy. (3081224)
1986
39
Central pontine myelinolysis diagnosed by magnetic resonance imaging. (3994319)
1985
40
Mild central pontine myelinolysis: a frequently undetected syndrome. (4092709)
1985
41
Central pontine myelinolysis: correlation between CT and electrophysiologic data. (6410789)
1983
42
Central pontine myelinolysis. Resolution shown by computed tomography. (6824443)
1983
43
Association between rise in serum sodium and central pontine myelinolysis. (7073246)
1982
44
Wernickes encephalopathy with central pontine myelinolysis presenting with hypothermia. (6954396)
1982
45
Central pontine myelinolysis in association with Hodgkin's lymphoma. (7301676)
1981
46
Rapid correction of hyponatremia causes demyelination: relation to central pontine myelinolysis. (7466381)
1981
47
Kernicterus and central pontine myelinolysis in a 14-year-old boy with fulminating viral hepatitis. (7212653)
1980
48
Association of central pontine myelinolysis and Marchiafave-Bignami disease. (569789)
1978
49
Central pontine myelinolysis. (4792161)
1973
50
Central pontine myelinolysis. A clinical and pathological study of 10 cases. (4655276)
1972

Genetic Variations for Central Pontine Myelinolysis

Expression for genes affiliated with Central Pontine Myelinolysis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Pontine Myelinolysis

Search GEO for disease gene expression data for Central Pontine Myelinolysis.

Pathways for genes affiliated with Central Pontine Myelinolysis

Sources:
38NCBI BioSystems Database
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Pathways related to Central Pontine Myelinolysis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MAG, MBP

Compounds for genes affiliated with Central Pontine Myelinolysis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Central Pontine Myelinolysis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1ctla4-ig459.8MBP, IL2RB
2methacholine45 1110.7MBP, IL2RB
32,3-cyclic nucleotide459.6MBP, MAG
4sulfatide459.6MAG, MBP
5phosphothreonine459.6MAG, MBP
6phosphoserine45 2410.5MBP, MAG
7melatonin45 60 29 11 2413.3IL2RB, AVP
8norepinephrine45 11 2411.3AVP, IL2RB, MBP
9ganglioside459.3MBP, MAG
10creatinine459.2MBP, IL2RB, AVP
11vanadate459.2MAG, MBP
12ivig459.2IL2RB, MAG, MBP
13phosphotyrosine459.1MAG, IL2RB, MBP
14thymidine45 2410.0IL2RB, MAG, MBP
15aspartate458.9MBP, MAG, IL2RB
1612-o-tetradecanoylphorbol 13-acetate458.9FOXM1, IL2RB, MBP
17threonine458.8MBP, MAG, IL2RB, AVP
18alanine458.8IL2RB, AVP, MAG, MBP
19serine458.5MAG, AVP, MBP, IL2RB

GO Terms for genes affiliated with Central Pontine Myelinolysis

Sources:
16Gene Ontology
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Biological processes related to Central Pontine Myelinolysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:0507719.3MAG, MBP

Products for genes affiliated with Central Pontine Myelinolysis

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Sources for Central Pontine Myelinolysis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet