MCID: CNT025
MIFTS: 38

Central Pontine Myelinolysis malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Central Pontine Myelinolysis

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Aliases & Descriptions for Central Pontine Myelinolysis:

Name: Central Pontine Myelinolysis 10 45 46 12
Myelinolysis, Central Pontine 36 65
Myelinolysis Central Pontine 47
 
Central Pontine Myelinosis 10
Cpm 45

Classifications:



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Disease Ontology10 DOID:636
ICD1027 G37.2
SNOMED-CT59 6807001
MeSH36 D017590
NCIt42 C84623
UMLS65 C0206083

Summaries for Central Pontine Myelinolysis

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NIH Rare Diseases:45 Central pontine myelinolysis (cpm) is a neurological disorder that most frequently occurs when sodium deficiency is treated too rapidly.  the part of the brain called the pons is especially sensitive and too much sodium can damage nerve fibers.  initial signs and symptoms appear within two to three days and include a depressed level of awareness, difficulty speaking, and difficulty swallowing.  additional symptoms often occur in the next one to two weeks, including impaired thinking, weakness or paralysis in the arms and legs, stiffness, impaired sensation, and difficulty with coordination.  severe cpm can lead to coma, “locked-in” syndrome, and death. treatment is focused on safely restoring sodium levels and relieving symptoms. many affected people improve over weeks to months; however, some have permanent disability or develop new symptoms later on including behavioral or intellectual impairment or movement disorders like parkinsonism or tremor. last updated: 7/21/2011

MalaCards based summary: Central Pontine Myelinolysis, also known as myelinolysis, central pontine, is related to gonadal dysgenesis and liposarcoma. An important gene associated with Central Pontine Myelinolysis is MBP (Myelin Basic Protein), and among its related pathways are Bile secretion and SIDS Susceptibility Pathways. Affiliated tissues include brain, pons and t cells, and related mouse phenotype hearing/vestibular/ear.

NINDS:46 Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in sodium concentration is accompanied by the movement of small molecules and pulls water from brain cells. Through a mechanism that is only partly understood, the shift in water and brain molecules leads to the destruction of myelin, a substance that surrounds and protects nerve fibers. Nerve cells (neurons) can also be damaged. Certain areas of the brain are particularly susceptible to myelinolysis, especially the part of the brain stem called the

Wikipedia:68 Central pontine myelinolysis (CPM), also known as Osmotic demyelination syndrome or Central pontine... more...

Related Diseases for Central Pontine Myelinolysis

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Diseases related to Central Pontine Myelinolysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 283)
idRelated DiseaseScoreTop Affiliating Genes
1gonadal dysgenesis30.2AQP1, AQP4
2liposarcoma11.5
3dentine erosion11.4
4extrapontine myelinolysis11.1
5thyroiditis10.6
6hepatitis10.6
7leukemia10.5
8retinitis10.5
9neuronitis10.5
10asthma10.4
11breast cancer10.4
12lymphoma10.4
13melanoma10.4
14cerebritis10.4
15pancreatitis10.4
16aneurysm10.4
17hepatocellular carcinoma10.3
18pulmonary hypertension10.3
19alopecia10.3
20brain injury10.3
21gastric cancer10.3
22liver disease10.3
23myelofibrosis10.3
24osteomyelitis10.3
25chlamydia10.3
26nephrotic syndrome10.3
27purpura10.3
28aortic aneurysm10.3
29ascariasis10.3
30pneumonia10.3
31adenoma10.3
32duodenitis10.3
33meningitis10.3
34neurofibroma10.3
35alopecia areata10.3
36glioblastoma10.3
37endotheliitis10.3
38pheochromocytoma10.2
39rheumatoid arthritis10.2
40neuroblastoma10.2
41colorectal cancer10.2
42myocardial infarction10.2
43lung cancer10.2
44atopy10.2
45melioidosis10.2
46prostate cancer10.2
47obesity10.2
48hodgkin lymphoma10.2
49bacteremia10.2
50hepatitis c virus10.2

Graphical network of the top 20 diseases related to Central Pontine Myelinolysis:



Diseases related to central pontine myelinolysis

Symptoms for Central Pontine Myelinolysis

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Drugs & Therapeutics for Central Pontine Myelinolysis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Central Pontine Myelinolysis


Cochrane evidence based reviews: myelinolysis, central pontine

Genetic Tests for Central Pontine Myelinolysis

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Anatomical Context for Central Pontine Myelinolysis

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MalaCards organs/tissues related to Central Pontine Myelinolysis:

33
Brain, Pons, T cells, Lung, Breast, Liver, Endothelial

Animal Models for Central Pontine Myelinolysis or affiliated genes

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MGI Mouse Phenotypes related to Central Pontine Myelinolysis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.9AQP1, AQP4, MBP

Publications for Central Pontine Myelinolysis

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Articles related to Central Pontine Myelinolysis:

(show top 50)    (show all 360)
idTitleAuthorsYear
1
Evaluation of AaDOP2 Receptor Antagonists Reveals Antidepressants and Antipsychotics as Novel Lead Molecules for Control of the Yellow Fever Mosquito, Aedes aegypti. (25332454)
2015
2
Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. (24796395)
2014
3
Effect of Lornoxicam Therapy on Expression of TLR2 and TLR4 mRNA during Systemic Complications of Acute Pancreatitis. (25403387)
2014
4
MDM2 SNP309 polymorphism is associated with colorectal cancer risk. (24797837)
2014
5
"It's us that have to deal with it seven days a week": carers and borderline personality disorder. (23054157)
2013
6
Age at onset and gender distribution of systemic lupus erythematosus, polymyositis/dermatomyositis, and systemic sclerosis in Japan. (22903259)
2013
7
Recurrent episodes of rhabdomyolysis in pontocerebellar hypoplasia type 2. (23177318)
2013
8
Occult hepatitis B virus infection among Egyptian blood donors. (23646231)
2013
9
Sarcoid reactions in the skin: 3 cases in association with B-cell lymphomas. (22063098)
2012
10
Contrast enhanced ultrasound in atherosclerotic carotid artery disease. (23222935)
2012
11
Targeted array CGH as a valuable molecular diagnostic approach: experience in the diagnosis of mitochondrial and metabolic disorders. (22494545)
2012
12
The CXCL16 A181V mutation selectively inhibits monocyte adhesion to CXCR6 but is not associated with human coronary heart disease. (21233446)
2011
13
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. (21907926)
2011
14
XRCC1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. (19329222)
2009
15
A fracture risk assessment model of the femur in children with osteogenesis imperfecta (OI) during gait. (19683956)
2009
16
Aliskiren (Rasilez), direct renin inhibitor]. (19051513)
2008
17
The Klotho gene family and the endocrine fibroblast growth factors. (18660672)
2008
18
Genotypic analysis of Asp299Gly and Thr399Ile polymorphism of Toll-like receptor 4 in systemic autoimmune diseases of Korean population. (17235555)
2007
19
Recurrent p.N767S mutation in the ATP2A2 gene in a Japanese family with haemorrhagic Darier disease clinically mimicking epidermolysis bullosa simplex with mottled pigmentation. (17635506)
2007
20
Metabolic conditions of fatty liver in non-diabetic obese women. (17923799)
2007
21
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. (17470554)
2007
22
Plasmodium vivax malaria relapses after primaquine prophylaxis. (17283643)
2006
23
The effect of fluvastatin on cICAM-1 as a biomarker of endothelial dysfunction in patients with dyslipidemia. (17164750)
2006
24
Binding of beta 2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells. (15486070)
2005
25
Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects. (16030156)
2005
26
Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death. (15845383)
2005
27
Pharmacokinetics and pharmacodynamics of etizolam are influenced by polymorphic CYP2C19 activity. (16261363)
2005
28
Leukocyte-endothelium interaction promotes SDF-1-dependent polarization of CXCR4. (12766157)
2003
29
Gastroesophageal junction adenocarcinoma. (12057146)
2000
30
A genetic analysis of synaptic development: pre- and postsynaptic dCBP control transmitter release at the Drosophila NMJ. (10774723)
2000
31
Computed tomographic features of hydrocele 'en bisac' with hydronephrosis. (10444151)
1999
32
Administration of intravenous immunoglobulin (IVIG) in vivo--down-regulatory effects on the IL-1 system. (9933433)
1999
33
Keratoacanthoma centrifugum marginatum arising from a scar after skin injury. (10487013)
1999
34
Lymph-node-based malignant lymphoma and reactive lymphadenopathy in eosinophilic fasciitis. (10555099)
1999
35
DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis. (9464502)
1998
36
Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. (9099960)
1997
37
Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients. (7613098)
1995
38
Genetic identification of a new Puumala virus strain causing severe hemorrhagic fever with renal syndrome in Germany. (7995985)
1994
39
Direct relationship between intracellular calcium mobilization and phospholipase D activation in prostaglandin E-stimulated human erythroleukemia cells. (1313295)
1992
40
cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. (2037293)
1991
41
Human teratocarcinoma cells express functional insulin-like growth factor I receptors. (2553456)
1989
42
Naevoid hypertrichosis--report of a patient with multiple lesions. (2805390)
1989
43
Hyperinsulinemia in acute intermittent porphyria. (3897010)
1985
44
The dysraphic state of the posterior fossa. Clinical review of the Dandy-Walker syndrome and the so-called arachnoid cysts. (536750)
1979
45
Letter: Self mutilation in Lesch-Nyhan syndrome. (4132504)
1974
46
Blood composition of horses before death from contagious bronchopneumonia. (13040883)
1952
47
Toxic encephalopathy occurring during topical therapy with asterol; report of two cases. (12990336)
1952
48
Blepharochalasis. (14877956)
1951
49
TREATMENT OF RAT-BITE FEVER WITH NOVARSENOBILLON. (20770586)
1922
50

Variations for Central Pontine Myelinolysis

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Expression for genes affiliated with Central Pontine Myelinolysis

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Search GEO for disease gene expression data for Central Pontine Myelinolysis.

Pathways for genes affiliated with Central Pontine Myelinolysis

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GO Terms for genes affiliated with Central Pontine Myelinolysis

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Biological processes related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycerol transportGO:00157939.6AQP1, AQP4
2renal water homeostasisGO:00030919.5AQP1, AVP
3water transportGO:00068339.4AQP1, AVP
4transmembrane transportGO:00550858.5AQP1, AQP4, AVP

Sources for Central Pontine Myelinolysis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet