CPM
MCID: CNT025
MIFTS: 42

Central Pontine Myelinolysis (CPM) malady

Neuronal diseases category

Summaries for Central Pontine Myelinolysis

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Sources:
42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Central pontine myelinolysis (cpm) is a neurological disorder that most frequently occurs when sodium deficiency is treated too rapidly.  the part of the brain called the pons is especially sensitive and too much sodium can damage nerve fibers.  initial signs and symptoms appear within two to three days and include a depressed level of awareness, difficulty speaking, and difficulty swallowing.  additional symptoms often occur in the next one to two weeks, including impaired thinking, weakness or paralysis in the arms and legs, stiffness, impaired sensation, and difficulty with coordination.  severe cpm can lead to coma, “locked-in” syndrome, and death. treatment is focused on safely restoring sodium levels and relieving symptoms. many affected people improve over weeks to months; however, some have permanent disability or develop new symptoms later on including behavioral or intellectual impairment or movement disorders like parkinsonism or tremor. last updated: 7/21/2011

MalaCards: Central Pontine Myelinolysis, also known as myelinolysis, central pontine, is related to diabetes mellitus and anorexia nervosa. An important gene associated with Central Pontine Myelinolysis is AVP (arginine vasopressin), and among its related pathways is Glial Cell Differentiation. The compounds ctla4-ig and methacholine have been mentioned in the context of this disorder. Affiliated tissues include brain, pons and liver.

NINDS:43 Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in sodium concentration is accompanied by the movement of small molecules and pulls water from brain cells. Through a mechanism that is only partly understood, the shift in water and brain molecules leads to the destruction of myelin, a substance that surrounds and protects nerve fibers. Nerve cells (neurons) can also be damaged. Certain areas of the brain are particularly susceptible to myelinolysis, especially the part of the brainstem called the

Wikipedia:63 Central pontine myelinolysis (CPM) is a neurological disease caused by severe damage of the myelin... more...

Aliases & Classifications for Central Pontine Myelinolysis

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

central pontine myelinolysis 8 42 43 10
myelinolysis, central pontine 60
myelinolysis central pontine 44
central pontine myelinosis 8
cpm 42


External Ids:

Disease Ontology8 DOID:636
MeSH34 D017590
SNOMED-CT56 6807001
NCIt39 C84623
ICD1025 G37.2

Related Diseases for Central Pontine Myelinolysis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Central Pontine Myelinolysis:



Diseases related to central pontine myelinolysis

Clinical Features for Central Pontine Myelinolysis

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Drugs & Therapeutics for Central Pontine Myelinolysis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Central Pontine Myelinolysis

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Anatomical Context for Central Pontine Myelinolysis

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32MalaCards
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MalaCards organs/tissues related to Central Pontine Myelinolysis:

32
Brain, Pons, Liver, Bone marrow, Bone, Lung, Endothelial, Pituitary

Animal Models for Central Pontine Myelinolysis or affiliated genes

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Publications for Central Pontine Myelinolysis

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50PubMed
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Articles related to Central Pontine Myelinolysis:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
A case of mistaken identity: alcohol withdrawal, schizophrenia, or central pontine myelinolysis? (22347796)
2012
2
Peduncular hallucinosis secondary to central pontine myelinolysis. (23252929)
2012
3
Plasmapheresis and Intravenous Immune Globulin Improve Neurologic Outcome of Central Pontine Myelinolysis Occurring Post Orthotopic Liver Transplant (February). (21304032)
2011
4
Central pontine myelinolysis as a cause of bilateral vocal fold immobility due to hyponatremia. (21271583)
2011
5
Central pontine myelinolysis. (21543311)
2011
6
Puzzles in practice. Central pontine myelinolysis (osmotic demyelination syndrome). (21608293)
2011
7
Central pontine and extrapontine myelinolysis. (19366078)
2008
8
Belly dancer's syndrome following central pontine and extrapontine myelinolysis. (17290456)
2007
9
Central pontine myelinolysis following 'optimal' rate of correction of hyponatraemia with a good clinical outcome. (17761038)
2007
10
Neuropsychological findings of extrapontine myelinolysis without central pontine myelinolysis. (17538198)
2007
11
Central pontine myelinolysis, an update. (16687066)
2006
12
Central pontine and extrapontine myelinolysis owing to disequilibrium syndrome. (12760433)
2003
13
Magnetic resonance imaging of sequelae of central pontine myelinolysis in chronic alcohol abusers. (14508621)
2003
14
Ataxic form of central pontine myelinolysis. (12849338)
2002
15
Diffusion-weighted MR findings of central pontine and extrapontine myelinolysis. (11903095)
2001
16
MR imaging of seven presumed cases of central pontine and extrapontine myelinolysis. (11512412)
2001
17
Central pontine myelinolysis and myocardial infarction following severe hypoglycemia. (11089780)
2000
18
Asymptomatic central pontine myelinolysis. (10496245)
1999
19
Reversal of MR findings of central pontine myelinolysis. (9843245)
1998
20
Central pontine myelinolysis and ataxia: an unusual manifestation of hypoglycaemia. (9545129)
1998
21
Central pontine myelinolysis after an operation. (9306999)
1997
22
Neurologic complications after orthotopic liver transplantation including central pontine myelinolysis. (8658834)
1996
23
MRI in central pontine myelinolysis. (7746384)
1995
24
Central pontine myelinolysis following orthotopic liver transplant: association with cyclosporine toxicity. (7784287)
1995
25
Central pontine myelinolysis as a complication of partial ornithine carbamoyl transferase deficiency. (7573173)
1995
26
An unusual case of central pontine myelinolysis. (8540908)
1995
27
Anorexia nervosa/bulimia and central pontine myelinolysis. (1521793)
1992
28
Delayed onset movement disorders as a complication of central pontine myelinolysis. (2057010)
1991
29
Central pontine myelinolysis: a case study. (2021557)
1991
30
Central pontine myelinolysis following correction of hyponatremia: MRI diagnosis. (2358009)
1990
31
Magnetic resonance imaging in central pontine myelinolysis. (2732743)
1989
32
Hyponatremia: cerebral symptoms and role in central pontine myelinolysis. (3705929)
1986
33
Brain-stem auditory evoked responses in diagnosis of central pontine myelinolysis. (3950661)
1986
34
Changing concepts in treatment of severe symptomatic hyponatremia. Rapid correction and possible relation to central pontine myelinolysis. (4014266)
1985
35
Evolution of central pontine myelinolysis on CT. (6421119)
1984
36
Central pontine myelinolysis in a 6-month-old infant with rapidly corrected hyponatremia. (6476799)
1984
37
Clinical and CT confirmed recovery from central pontine myelinolysis. (6717794)
1984
38
Hemiparesis apparently due to central pontine myelinolysis following hyponatremia. (6651252)
1983
39
Central pontine myelinolysis: an immunofluorescent study. (7051753)
1982
40
Central pontine myelinolysis and rapid correction of hyponatremia. (7147196)
1982
41
Demyelination of the lateral geniculate nucleus in central pontine myelinolysis. (7235634)
1981
42
Central pontine myelinolysis. A study of 37 cases in 1,000 consecutive autopsies. (7211204)
1981
43
Central pontine myelinolysis. Considerations on etiology, diagnosis, and treatment. (571058)
1979
44
Central pontine myelinolysis. (371456)
1979
45
Hyponatremia and central pontine myelinolysis. (557757)
1977
46
Central pontine myelinolysis. An ultrastructural and elemental study. (950576)
1976
47
Brainstem auditory potentials in clinically diagnosed central pontine myelinolysis. (1028266)
1976
48
Central pontine myelinolysis. (4850931)
1974
49
Central pontine myelinolysis. Report of six cases and review of the literature. (5622734)
1967
50
CENTRAL PONTINE MYELINOLYSIS. (14200786)
1964

Genetic Variations for Central Pontine Myelinolysis

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Expression for genes affiliated with Central Pontine Myelinolysis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Pontine Myelinolysis

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Pathways for genes affiliated with Central Pontine Myelinolysis

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37NCBI BioSystems Database
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Pathways related to Central Pontine Myelinolysis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MAG, MBP

Compounds for genes affiliated with Central Pontine Myelinolysis

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Central Pontine Myelinolysis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1ctla4-ig449.8IL2RB, MBP
2methacholine44 1110.7IL2RB, MBP
32,3-cyclic nucleotide449.6MAG, MBP
4sulfatide449.6MBP, MAG
5phosphothreonine449.6MAG, MBP
6phosphoserine44 2410.5MAG, MBP
7melatonin44 59 28 11 2413.3IL2RB, AVP
8norepinephrine44 11 2411.3MBP, IL2RB, AVP
9ganglioside449.3MAG, MBP
10creatinine449.2AVP, IL2RB, MBP
11vanadate449.2MAG, MBP
12ivig449.2IL2RB, MAG, MBP
13phosphotyrosine449.1MBP, MAG, IL2RB
14thymidine44 2410.0MBP, MAG, IL2RB
15aspartate448.9MBP, MAG, IL2RB
1612-o-tetradecanoylphorbol 13-acetate448.9IL2RB, FOXM1, MBP
17threonine448.8AVP, IL2RB, MAG, MBP
18alanine448.8MBP, MAG, IL2RB, AVP
19serine448.5AVP, IL2RB, MAG, MBP

GO Terms for genes affiliated with Central Pontine Myelinolysis

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16Gene Ontology
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Biological processes related to Central Pontine Myelinolysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:0507719.3MAG, MBP

Products for genes affiliated with Central Pontine Myelinolysis

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  • Antibodies
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  • Lysates
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Sources for Central Pontine Myelinolysis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet