MCID: CNT025
MIFTS: 41

Central Pontine Myelinolysis malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Central Pontine Myelinolysis

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Aliases & Descriptions for Central Pontine Myelinolysis:

Name: Central Pontine Myelinolysis 10 45 46 12
Myelinolysis, Central Pontine 65 36
Myelinolysis Central Pontine 47
 
Central Pontine Myelinosis 10
Cpm 45


Classifications:



External Ids:

Disease Ontology10 DOID:636
NCIt42 C84623
SNOMED-CT59 6807001
MeSH36 D017590
ICD1027 G37.2

Summaries for Central Pontine Myelinolysis

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NIH Rare Diseases:45 Central pontine myelinolysis (cpm) is a neurological disorder that most frequently occurs when sodium deficiency is treated too rapidly.  the part of the brain called the pons is especially sensitive and too much sodium can damage nerve fibers.  initial signs and symptoms appear within two to three days and include a depressed level of awareness, difficulty speaking, and difficulty swallowing.  additional symptoms often occur in the next one to two weeks, including impaired thinking, weakness or paralysis in the arms and legs, stiffness, impaired sensation, and difficulty with coordination.  severe cpm can lead to coma, “locked-in” syndrome, and death. treatment is focused on safely restoring sodium levels and relieving symptoms. many affected people improve over weeks to months; however, some have permanent disability or develop new symptoms later on including behavioral or intellectual impairment or movement disorders like parkinsonism or tremor. last updated: 7/21/2011

MalaCards based summary: Central Pontine Myelinolysis, also known as myelinolysis, central pontine, is related to secondary syphilis and encephalopathy. An important gene associated with Central Pontine Myelinolysis is MBP (Myelin Basic Protein), and among its related pathways are Bile secretion and Glial Cell Differentiation. Affiliated tissues include brain, pons and liver, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

NINDS:46 Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in sodium concentration is accompanied by the movement of small molecules and pulls water from brain cells. Through a mechanism that is only partly understood, the shift in water and brain molecules leads to the destruction of myelin, a substance that surrounds and protects nerve fibers. Nerve cells (neurons) can also be damaged. Certain areas of the brain are particularly susceptible to myelinolysis, especially the part of the brainstem called the

Wikipedia:68 Central pontine myelinolysis (CPM), also known as Osmotic demyelination syndrome or Central pontine... more...

Related Diseases for Central Pontine Myelinolysis

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Graphical network of the top 20 diseases related to Central Pontine Myelinolysis:



Diseases related to central pontine myelinolysis

Symptoms for Central Pontine Myelinolysis

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Drugs & Therapeutics for Central Pontine Myelinolysis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Central Pontine Myelinolysis


Cochrane evidence based reviews: Myelinolysis, Central Pontine

Genetic Tests for Central Pontine Myelinolysis

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Anatomical Context for Central Pontine Myelinolysis

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MalaCards organs/tissues related to Central Pontine Myelinolysis:

33
Brain, Pons, Liver, Bone, Endothelial, Pituitary, Lung

Animal Models for Central Pontine Myelinolysis or affiliated genes

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MGI Mouse Phenotypes related to Central Pontine Myelinolysis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6AQP1, AQP4, BCL2, MBP
2MP:00053918.3AQP1, AQP4, BCL2, MBP
3MP:00053678.3AQP1, AQP4, AVP, BCL2
4MP:00036317.1AQP1, AQP4, AVP, BCL2, MAG, MBP
5MP:00053866.8AQP1, AQP4, AVP, BCL2, MAG, MBP

Publications for Central Pontine Myelinolysis

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Articles related to Central Pontine Myelinolysis:

(show top 50)    (show all 357)
idTitleAuthorsYear
1
Central pontine myelinolysis: a rare presentation secondary to hyperglycaemia. (25917480)
2015
2
Osmotic demyelination syndrome: central pontine myelinolysis and extrapontine myelinolysis. (24745890)
2014
3
Central pontine myelinolysis in the hyperosmolar hyperglycaemic state. (22922267)
2013
4
Rare association of central pontine myelinolysis with infantile tremor syndrome. (22412274)
2012
5
Corticospinal tract and pontocerebellar fiber of central pontine myelinolysis. (23342326)
2012
6
Plasmapheresis and Intravenous Immune Globulin Improve Neurologic Outcome of Central Pontine Myelinolysis Occurring Post Orthotopic Liver Transplant (February). (21304032)
2011
7
Central pontine myelinolysis as a cause of bilateral vocal fold immobility due to hyponatremia. (21271583)
2011
8
Central pontine myelinolysis secondary to hypokalaemic nephrogenic diabetes insipidus. (19940203)
2010
9
Idiopathic central pontine myelinolysis in an eunatremic patient with AIDS. (19564726)
2009
10
Central pontine myelinolysis despite slow sodium rise in a case of severe community-acquired hyponatraemia. (19157357)
2009
11
The corticobasal syndrome triggered by central pontine myelinolysis. (16420397)
2006
12
Central pontine myelinolysis, an update. (16687066)
2006
13
Central pontine myelinolysis associated with hypokalaemia in anorexia nervosa. (15026526)
2004
14
Efficacy of clozapine in a non-schizophrenic patient with psychogenic polydipsia and central pontine myelinolysis. (12404683)
2002
15
Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity. (12630660)
2002
16
Central pontine myelinolysis: association with parenteral magnesium administration. (10870372)
2000
17
Severe hyponatraemia secondary to beer potomania complicated by central pontine myelinolysis. (10622059)
1998
18
Central pontine myelinolysis in a normonatremic child. (9255014)
1997
19
Central pontine myelinolysis in a previously healthy 4-year-old child with acute rotavirus gastroenteritis. (9113955)
1997
20
Extra and central pontine myelinolysis in a child with adrenal insufficiency. (9367298)
1997
21
Persistence of MRI changes in central pontine myelinolysis. (8971102)
1996
22
A chronic glue sniffer with hyperchloraemia metabolic acidosis, rhabdomyolysis, irreversible quadriplegia, central pontine myelinolysis, and hypothyroidism. (8918637)
1996
23
A case of central pontine myelinolysis after surgical removal of a pituitary tumor. (8677485)
1996
24
Central pontine myelinolysis: report of an asymptomatic case. (7727208)
1995
25
Central pontine myelinolysis secondary to frequent and rapid shifts in plasma glucose in a diabetic haemodialysis patient. (8396751)
1993
26
Movement disorders as sequelae of central pontine myelinolysis: report of three cases. (1584236)
1992
27
Central pontine myelinolysis and pontine lesions after rapid correction of hyponatremia: a prospective magnetic resonance imaging study. (2301929)
1990
28
Magnetic resonance imaging in central pontine myelinolysis. (2277006)
1990
29
Central pontine myelinolysis after liver transplantation. (2648187)
1989
30
Central pontine myelinolysis and its imitators: MR findings. (3406409)
1988
31
Acquired focal dystonia following recovery from central pontine myelinolysis. (3225594)
1988
32
Central pontine myelinolysis: report of a case with distinctive appearance on MR imaging. (3111231)
1987
33
Central pontine myelinolysis: diagnosis by computed tomography, magnetic resonance and evoked potentials. (3804711)
1986
34
Distribution of demyelinating lesions in pontine and extrapontine myelinolysis--three autopsy cases including one case devoid of central pontine myelinolysis. (3962604)
1986
35
Central pontine myelinolysis and abnormalities in serum sodium. (3815936)
1986
36
Central pontine myelinolysis accompanied by multifocal pseudocalcifications. (4083010)
1985
37
Changing concepts in treatment of severe symptomatic hyponatremia. Rapid correction and possible relation to central pontine myelinolysis. (4014266)
1985
38
Central pontine myelinolysis with widespread extrapontine lesions: a report of two cases. (6568941)
1984
39
Recovery from probably central pontine myelinolysis associated with Addison's disease. (6824444)
1983
40
Central pontine myelinolysis: correlation between CT and electrophysiologic data. (6410789)
1983
41
Central pontine myelinolysis. (7329883)
1981
42
Central pontine myelinolysis following hyponatremia, demonstrated by computerized tomography. (518040)
1979
43
Central pontine myelinolysis. A clinical reappraisal. (843256)
1977
44
Central pontine myelinolysis. (4792161)
1973
45
Central pontine myelinolysis and Rosenthal fibers of the brainstem. Association with emaciation and prolonged intravenous hyperalimentation. (4117115)
1972
46
Central pontine myelinolysis in childhood. (5110124)
1971
47
Subacute necrotizing encephalomyelopathy. Its relationship to central pontine myelinolysis. (5478948)
1970
48
CENTRAL PONTINE MYELINOLYSIS. (14200786)
1964
49
CENTRAL PONTINE MYELINOLYSIS. (A CASE REPORT). (14191012)
1964
50
Central pontine myelinolysis. (13685966)
1960

Variations for Central Pontine Myelinolysis

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Expression for genes affiliated with Central Pontine Myelinolysis

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Search GEO for disease gene expression data for Central Pontine Myelinolysis.

Pathways for genes affiliated with Central Pontine Myelinolysis

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GO Terms for genes affiliated with Central Pontine Myelinolysis

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Cellular components related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:00432098.6BCL2, MAG, MBP

Biological processes related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cellular water homeostasisGO:000999210.1AQP1, AQP4
2glycerol transportGO:001579310.1AQP1, AQP4
3substantia nigra developmentGO:00217629.8MAG, MBP
4negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.7AQP1, AVP
5cellular response to mechanical stimulusGO:00712609.7AQP1, MAG
6response to nicotineGO:00350949.6AVP, BCL2
7positive regulation of peptidyl-serine phosphorylationGO:00331389.5AVP, BCL2
8multicellular organismal water homeostasisGO:00508919.5AQP1, AQP4, AVP
9renal water homeostasisGO:00030919.5AQP1, AQP4, AVP
10water transportGO:00068339.5AQP1, AQP4, AVP
11positive regulation of cell growthGO:00303079.4AVP, BCL2
12response to toxic substanceGO:00096369.2BCL2, MBP
13cellular response to hypoxiaGO:00714568.9AQP1, BCL2
14negative regulation of apoptotic processGO:00430668.7AQP1, AVP, BCL2
15transmembrane transportGO:00550858.4AQP1, AQP4, AVP, BCL2

Molecular functions related to Central Pontine Myelinolysis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1water transmembrane transporter activityGO:00053729.6AQP1, AQP4
2water channel activityGO:00152509.6AQP1, AQP4
3glycerol channel activityGO:00152549.5AQP1, AQP4
4protease bindingGO:00020209.2BCL2, MBP

Sources for Central Pontine Myelinolysis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet