MCID: CNT075
MIFTS: 50

Central Precocious Puberty

Categories: Reproductive diseases, Endocrine diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Central Precocious Puberty

MalaCards integrated aliases for Central Precocious Puberty:

Name: Central Precocious Puberty 25 56 29
Precocious Puberty, Central 13 69
Cpp 25 56
Gonadotropin-Dependent Precocious Puberty 25
Gonadotropin-Dependant Precocious Puberty 56

Characteristics:

Orphanet epidemiological data:

56
central precocious puberty
Inheritance: Autosomal dominant,Not applicable; Age of onset: Childhood,Infancy; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 56 ORPHA759
UMLS via Orphanet 70 C0342543
ICD10 via Orphanet 34 E22.8

Summaries for Central Precocious Puberty

Genetics Home Reference : 25 Central precocious puberty is a condition that causes early sexual development in girls and boys. While puberty normally starts between ages 8 and 13 in girls and between ages 9 and 14 in boys, girls with central precocious puberty begin exhibiting signs before age 8, and boys with this disorder begin before age 9. Signs of puberty include development of pubic and underarm hair, a rapid increase in height (commonly referred to as a "growth spurt"), acne, and underarm odor. Girls also develop breasts and begin their menstrual periods. Boys have growth of the penis and testes and deepening of the voice. Because of the early growth spurt, children with central precocious puberty may be taller than their peers; however, they may stop growing abnormally early. Without proper treatment, some affected individuals are shorter in adulthood compared with other members of their family. Developing ahead of their peers can be emotionally difficult for affected individuals and may lead to psychological and behavioral problems.

MalaCards based summary : Central Precocious Puberty, also known as precocious puberty, central, is related to idiopathic central precocious puberty and secondary central precocious puberty, and has symptoms including isosexual precocious puberty, increased circulating gonadotropin level and overgrowth. An important gene associated with Central Precocious Puberty is KISS1R (KISS1 Receptor), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Leuprolide and Antineoplastic Agents, Hormonal have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and pituitary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and endocrine/exocrine gland

Related Diseases for Central Precocious Puberty

Diseases in the Precocious Puberty family:

Precocious Puberty, Central, 2 Precocious Puberty, Central, 1
Central Precocious Puberty Secondary Central Precocious Puberty

Diseases related to Central Precocious Puberty via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 idiopathic central precocious puberty 12.3
2 secondary central precocious puberty 12.2
3 choroid plexus papilloma 11.9
4 precocious puberty, central, 2 11.8
5 precocious puberty, central, 1 11.8
6 precocious puberty 11.6
7 hypothalamic hamartomas, somatic 11.0
8 atypical choroid plexus papilloma 10.8
9 prostatitis 10.2
10 nephrogenic adenofibroma 10.1 GNRH1 LEP
11 acute gonococcal salpingitis 10.1 GNRH1 LEP
12 obesity 10.1
13 insulin-like growth factor i 10.1
14 polycystic ovary syndrome 10.1
15 congenital adrenal hyperplasia 10.1
16 vaginitis 10.1
17 hyperandrogenism 10.0
18 growth hormone deficiency 10.0
19 avoidant personality disorder 10.0 GNRH1 KISS1
20 prader-willi syndrome 9.9
21 fetal parvovirus syndrome 9.9 IGF1 LEP
22 neurogenic arthropathy 9.9 IGF1 LEP
23 bladder sarcoma 9.9 IGF1 LEP
24 chondroma 9.9 IGF1 LEP
25 uterine ligament clear cell adenocarcinoma 9.9 GNRH1 IGF1
26 renal-hepatic-pancreatic dysplasia 9.9 GNRH1 IGF1
27 adamantinous craniopharyngioma 9.9 GNRH1 IGF1
28 pelvic muscle wasting 9.9 GNRH1 IGF1
29 haverhill fever 9.9 GNRH1 IGF1
30 alpha-methylacyl-coa racemase deficiency 9.8 GNRH1 IGF1
31 medullomyoblastoma 9.8 GNRH1 IGF1
32 diabetic encephalopathy 9.8 IGF1 LEP
33 allergic asthma 9.8 GNRH1 IGF1
34 hyperprolactinemia 9.8
35 williams-beuren syndrome 9.8
36 phenylketonuria 9.8
37 neurofibromatosis, type 1 9.8
38 hypophosphatemic rickets 9.8
39 cerebral palsy 9.8
40 hydrocephalus 9.8
41 fibrous dysplasia 9.8
42 hypogonadotropic hypogonadism 9.8
43 rickets 9.8
44 neonatal diabetes mellitus 9.8
45 epilepsy 9.8
46 hypogonadism 9.8
47 astrocytoma 9.8
48 rhabdomyosarcoma 9.8
49 histiocytosis 9.8
50 cerebritis 9.8

Graphical network of the top 20 diseases related to Central Precocious Puberty:



Diseases related to Central Precocious Puberty

Symptoms & Phenotypes for Central Precocious Puberty

Human phenotypes related to Central Precocious Puberty:

56 32 (show all 15)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 isosexual precocious puberty 56 32 obligate (100%) Obligate (100%) HP:0008236
2 increased circulating gonadotropin level 56 32 frequent (33%) Frequent (79-30%) HP:0000837
3 overgrowth 56 32 frequent (33%) Frequent (79-30%) HP:0001548
4 accelerated bone age after puberty 56 32 frequent (33%) Frequent (79-30%) HP:0002805
5 proportionate short stature 56 32 frequent (33%) Frequent (79-30%) HP:0003508
6 abnormality of secondary sexual hair 56 32 frequent (33%) Frequent (79-30%) HP:0009888
7 premature thelarche 56 32 frequent (33%) Frequent (79-30%) HP:0010314
8 acne 56 32 occasional (7.5%) Occasional (29-5%) HP:0001061
9 obesity 56 32 occasional (7.5%) Occasional (29-5%) HP:0001513
10 hypothalamic hamartoma 56 32 occasional (7.5%) Occasional (29-5%) HP:0002444
11 prenatal maternal abnormality 56 32 occasional (7.5%) Occasional (29-5%) HP:0002686
12 hydrocephalus 56 32 very rare (1%) Very rare (<4-1%) HP:0000238
13 cafe-au-lait spot 56 32 very rare (1%) Very rare (<4-1%) HP:0000957
14 meningitis 56 32 very rare (1%) Very rare (<4-1%) HP:0001287
15 increased body weight 56 Frequent (79-30%)

GenomeRNAi Phenotypes related to Central Precocious Puberty according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.62 LEP IGF1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.62 LEP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.62 KISS1R
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.62 IGF1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.62 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.62 IGF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.62 IGF1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.62 KISS1R
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.62 IGF1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.62 KISS1R
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.62 IGF1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.62 IGF1 KISS1R LEP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.62 LEP
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.62 IGF1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.62 LEP
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.62 KISS1R
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.62 IGF1

MGI Mouse Phenotypes related to Central Precocious Puberty:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.77 LEP IGF1 KISS1 KISS1R GNRH1
2 integument MP:0010771 9.72 IGF1 KISS1 KISS1R LEP GNRH1
3 digestive/alimentary MP:0005381 9.71 GNRH1 LEP KISS1 KISS1R
4 adipose tissue MP:0005375 9.61 IGF1 KISS1 LEP
5 liver/biliary system MP:0005370 9.56 GNRH1 LEP KISS1 KISS1R
6 nervous system MP:0003631 9.55 GNRH1 LEP IGF1 KISS1 KISS1R
7 renal/urinary system MP:0005367 9.35 IGF1 KISS1 KISS1R LEP GNRH1
8 reproductive system MP:0005389 9.02 IGF1 KISS1 KISS1R LEP GNRH1

Drugs & Therapeutics for Central Precocious Puberty

Drugs for Central Precocious Puberty (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Leuprolide Approved, Investigational Phase 4,Phase 3 53714-56-0 3911 657181
2 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
3 Contraceptive Agents Phase 4,Phase 3
4 Luteolytic Agents Phase 4,Phase 3
5 Triptorelin Pamoate Phase 4,Phase 3
6 Deslorelin Phase 4,Phase 3,Phase 2
7 Fertility Agents Phase 4,Phase 3
8 Hormones Phase 4,Phase 3,Phase 2
9 Pharmaceutical Solutions Phase 3
10
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
11
Testolactone Approved Phase 2 968-93-4 13769
12
Testosterone Approved, Investigational Phase 2 58-22-0 6013
13
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
14
Bicalutamide Approved Phase 2 90357-06-5 56069 2375
15 diuretics Phase 2
16 Diuretics, Potassium Sparing Phase 2
17 Hormone Antagonists Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
19 Mineralocorticoid Receptor Antagonists Phase 2
20 Mineralocorticoids Phase 2
21 Natriuretic Agents Phase 2
22 Androgens Phase 2
23 Androgen Antagonists Phase 2
24 Aromatase Inhibitors Phase 2
25 Estrogen Antagonists Phase 2
26 Estrogens Phase 2
27 Steroid Synthesis Inhibitors Phase 2
28
Epinephrine Approved, Vet_approved 51-43-4 5816
29 Racepinephrine Approved
30 Epinephryl borate
31 Soy Bean Nutraceutical

Interventional clinical trials:

(show all 25)

id Name Status NCT ID Phase Drugs
1 Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls Unknown status NCT01278290 Phase 4 Triptorelin acetate and Gonadorelin acetate;Gonadorelin acetate and Triptorelin acetate
2 Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children Unknown status NCT00438217 Phase 4 Triptorelin (GnRH agonists);Leuprolide (GnRH agonists)
3 Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty Completed NCT02920515 Phase 4 Triptorlin or Leuprorelin;Zhibo dihuang pills;Dabu ying pills
4 The Clinical Trial to Evaluate the Efficacy and Safety of Luphere Depot Inj. 3.75mg(Leuprolide Acetate 3.75mg) in Patients With Precocious Puberty Completed NCT01634321 Phase 4 Luphere depot 3.75mg(Leuprolide acetate 3.75mg)
5 Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty Recruiting NCT03316482 Phase 4 Leuplin DPS 11.25mg
6 Analysis of Body Mass Index in Central Precocious Puberty Patients Treated With Leuprolide Acetate Recruiting NCT02974270 Phase 4 Leuprolide
7 A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty in Chinese Patients Active, not recruiting NCT02427958 Phase 4 Leuprorelin
8 Histrelin Subcutaneous Implant in Children With Central Precocious Puberty Completed NCT00779103 Phase 3 Histrelin Subcutaneous Implant
9 Safety Extension Study Of Leuprolide Acetate (Lupron Depot) In The Treatment Of Central Precocious Puberty Completed NCT00667446 Phase 3 Leuprolide Acetate 3 Month Depot
10 Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty Completed NCT01467882 Phase 3 Triptorelin
11 Study of Lupron Depot In The Treatment of Central Precocious Puberty Completed NCT00660010 Phase 3 Lupron (leuprolide acetate)
12 A Study of Leuprolide 11.25 mg and 30 mg Administered Every 3 Months to Treat Central Precocious Puberty Completed NCT00635817 Phase 3 Leuprolide acetate 11.25 mg;Leuprolide acetate 30 mg
13 Pharmacokinetic Study of Leuprolide Acetate Injectable Suspension in the Treatment of Central Precocious Puberty Active, not recruiting NCT02452931 Phase 3 Leuprolide Acetate 45 mg
14 Treatment of Boys With Precocious Puberty Completed NCT00001202 Phase 2 Spironolactone;Testolactone;Deslorelin
15 Pediatrics Testotoxicosis Study [Bicalutamide Anastrozole Treatment for Testotoxicosis] Active, not recruiting NCT00094328 Phase 2 Bicalutamide;Anastrozole
16 Markers of Pubertal Suppression During Therapy for Precocious Puberty Unknown status NCT02006680
17 First-Voided Urinary LH vs. GnRH-stimulation in Differentiating Slowly- From Rapidly Progressive-Precocious Puberty Unknown status NCT01800565
18 Psychosocial Impact of Early Puberty in Girls Aged 6 to 8 Years Completed NCT01679925
19 Purification of Testis-Stimulating Factor in Precocious Puberty Completed NCT00004344 leuprolide;testosterone
20 A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty Among Chinese Participants Recruiting NCT02993926 Leuprorelin
21 Effect of a GnRH Injection on Ghrelin Concentrations in Girls With Suspected Premature Puberty Recruiting NCT02431416 Gonadotropin releasing hormone (GnRH);Sodium Chloride
22 The Effect of Medical Clown on the Pain and Anxiety Perception During LRH Analog Treatment or GH Provocation Test Recruiting NCT02199587
23 Association Between Soy Based Formula in Infancy and Puberty Recruiting NCT02908971
24 Long-term Outcome of GnRH Analogues Treatment of Children With Idiopathic Central Precocious Puberty Enrolling by invitation NCT02790112
25 Natural History Study of Patients With Excess Androgen Enrolling by invitation NCT00250159

Search NIH Clinical Center for Central Precocious Puberty

Genetic Tests for Central Precocious Puberty

Genetic tests related to Central Precocious Puberty:

id Genetic test Affiliating Genes
1 Central Precocious Puberty 29

Anatomical Context for Central Precocious Puberty

MalaCards organs/tissues related to Central Precocious Puberty:

39
Testes, Bone, Pituitary, Testis, Ovary, Brain, Pineal

Publications for Central Precocious Puberty

Articles related to Central Precocious Puberty:

(show top 50) (show all 407)
id Title Authors Year
1
Genetic Variations of the KISS1R Gene in Korean Girls with Central Precocious Puberty. ( 27914139 )
2017
2
Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study. ( 28791047 )
2017
3
Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty. ( 28791667 )
2017
4
Lung Function in Women with Idiopathic Central Precocious Puberty: A Pilot Studya8c. ( 28114141 )
2017
5
Central Precocious Puberty Secondary to Adrenocortical Adenoma in a Female Child: Case Report and Review of the Literature. ( 28578183 )
2017
6
Change in body mass index and insulin resistance after 1-year treatment with gonadotropin-releasing hormone agonists in girls with central precocious puberty. ( 28443256 )
2017
7
MKRN3 levels in girls with central precocious puberty and correlation with sexual hormone levels: a pilot study. ( 28299573 )
2017
8
SERUM NESFATIN-1 LEVELS IN GIRLS WITH IDIOPATHIC CENTRAL PRECOCIOUS PUBERTY. ( 28739555 )
2017
9
Effects of pomegranate extract in supplementing gonadotropin-releasing hormone therapy on idiopathic central precocious puberty in Chinese girls: a randomized, placebo-controlled, double-blind clinical trial. ( 28091641 )
2017
10
The different effects of gonadotropin-releasing hormone agonist therapy on body mass index and growth between normal-weight and overweight girls with central precocious puberty. ( 28443259 )
2017
11
Increased high molecular weight adiponectin, but decreased total adiponectin and kisspeptin, in central precocious puberty compared with aged-matched prepubertal girls. ( 28610651 )
2017
12
Long-term Outcomes of Patients with Central Precocious Puberty due to Hypothalamic Hamartoma After GnRH Analog Treatment: Anthropometric, Metabolic and Reproductive Aspects. ( 28558376 )
2017
13
Meta-Analysis of Paediatric Patients with Central Precocious Puberty Treated with Intramuscular Triptorelin 11.25 mg 3-Month Prolonged-Release Formulationa8c. ( 28334719 )
2017
14
Commentary: Cognitive, Emotional, and Psychosocial Functioning of Girls Treated with Pharmacological Puberty Blockage for Idiopathic Central Precocious Puberty. ( 28167925 )
2017
15
Marked geographic patterns in the incidence of idiopathic central precocious puberty: a nationwide study in France. ( 28890442 )
2017
16
The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). ( 28251550 )
2017
17
The first Japanese case of central precocious puberty with a novel MKRN3 mutation. ( 28546864 )
2017
18
Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty. ( 28324015 )
2017
19
Metabolic Outcomes, Bone Health, and Risk of Polycystic Ovary Syndrome in Girls with Idiopathic Central Precocious Puberty Treated with Gonadotropin-Releasing Hormone Analogues. ( 28391271 )
2017
20
Molecular Screening of MKRN3, DLK1, and KCNK9 Genes in Girls with Idiopathic Central Precocious Puberty. ( 28672280 )
2017
21
Assessment of stress levels in girls with central precocious puberty before and during long-acting gonadotropin-releasing hormone agonist treatment: a pilot study. ( 28599388 )
2017
22
Changes in body mass index during gonadotropin-releasing hormone agonist treatment for central precocious puberty and early puberty. ( 27444748 )
2016
23
Underdiagnosis of central precocious puberty in boys with loss-of function mutations of MKRN3. ( 28043686 )
2016
24
The Diagnostic Value of Pelvic Ultrasound in Girls with Central Precocious Puberty. ( 26866003 )
2016
25
Changes in Body Mass Index in Girls with Idiopathic Central Precocious Puberty under Gonadotropin-Releasing Hormone Analogue Therapy: The Spanish Registry. ( 27529349 )
2016
26
NR0B1 Frameshift Mutation in a Boy with Idiopathic Central Precocious Puberty. ( 27648561 )
2016
27
Central precocious puberty in children with devastating brain damage: Two cases. ( 27625256 )
2016
28
Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty. ( 26675317 )
2016
29
High Frequency of MKRN3 Mutations in Male Central Precocious Puberty Previously Classified as Idiopathic. ( 27225315 )
2016
30
Cognitive, Emotional, and Psychosocial Functioning of Girls Treated with Pharmacological Puberty Blockage for Idiopathic Central Precocious Puberty. ( 27462292 )
2016
31
An update on the genetic causes of central precocious puberty. ( 27462581 )
2016
32
Influence of obesity on luteinizing hormone secretion during gonadotropin-releasing hormone stimulation tests in girls with central precocious puberty. ( 27215137 )
2016
33
Central precocious puberty in a boy with 22q13 deletion syndrome and NOTCH-1 gene duplication. ( 27235670 )
2016
34
Causes, diagnosis, and treatment of central precocious puberty. ( 26852255 )
2016
35
Sexual Precocity--Genetic Bases of Central Precocious Puberty and Autonomous Gonadal Activation. ( 26680572 )
2016
36
Leptin and adiponectin levels in girls with central precocious puberty before and during GnRH agonist treatment. ( 28164072 )
2016
37
An 11-month-old girl with central precocious puberty caused by hypothalamic hamartoma. ( 28164078 )
2016
38
Central precocious puberty due to hypothalamic hamartoma in neurofibromatosis type 1. ( 26732170 )
2016
39
Boy with central precocious puberty probably due to a peripheral cause. ( 27256994 )
2016
40
Efficacy and safety of triptorelin 6-month formulation in patients with central precocious puberty. ( 26887034 )
2016
41
Basal Serum Neurokinin B Level can be used to Differentiate Idiopathic Central Precocious Puberty from Premature Thelarche in Girls. ( 28008860 )
2016
42
Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls. ( 27304100 )
2016
43
Two Frameshift Mutations in MKRN3 in Turkish Patients with Familial Central Precocious Puberty. ( 27798941 )
2016
44
Effects and safety of combination therapy with gonadotropin-releasing hormone analogue and growth hormone in girls with idiopathic central precocious puberty: a meta-analysis. ( 27225286 )
2016
45
Body mass index in girls with idiopathic central precocious puberty during and after treatment with GnRH analogues. ( 27499763 )
2016
46
Mutations in the maternally imprinted gene MKRN3 are common in familial central precocious puberty. ( 26431553 )
2016
47
Central precocious puberty: revisiting the diagnosis and therapeutic management. ( 27191050 )
2016
48
Monitoring treatment of central precocious puberty using basal luteinizing hormone levels and practical considerations for dosing with a 3-month leuprolide acetate formulation. ( 27740929 )
2016
49
Central Precocious Puberty: A Case Report. ( 27941749 )
2016
50
Clinical Exome Sequencing Reveals MKRN3 Pathogenic Variants in Familial and Nonfamilial Idiopathic Central Precocious Puberty. ( 27931036 )
2016

Variations for Central Precocious Puberty

ClinVar genetic disease variations for Central Precocious Puberty:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 KISS1R NM_032551.4(KISS1R): c.1157G> C (p.Arg386Pro) single nucleotide variant Pathogenic/Likely pathogenic rs121908499 GRCh37 Chromosome 19, 920708: 920708

Expression for Central Precocious Puberty

Search GEO for disease gene expression data for Central Precocious Puberty.

Pathways for Central Precocious Puberty

Pathways related to Central Precocious Puberty according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.61 IGF1 LEP

GO Terms for Central Precocious Puberty

Cellular components related to Central Precocious Puberty according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 GNRH1 IGF1 KISS1 LEP

Biological processes related to Central Precocious Puberty according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.54 GNRH1 IGF1 LEP
2 response to ethanol GO:0045471 9.43 GNRH1 LEP
3 female pregnancy GO:0007565 9.4 GNRH1 LEP
4 positive regulation of MAPK cascade GO:0043410 9.33 IGF1 KISS1 LEP
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.32 IGF1 LEP
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.96 IGF1
7 bone mineralization involved in bone maturation GO:0035630 8.96 IGF1 LEP
8 positive regulation of luteinizing hormone secretion GO:0033686 8.62 KISS1 LEP

Molecular functions related to Central Precocious Puberty according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 GNRH1 IGF1 LEP

Sources for Central Precocious Puberty

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
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55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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