MCID: CNT028
MIFTS: 49

Central Retinal Artery Occlusion malady

Eye diseases category

Summaries for Central Retinal Artery Occlusion

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63Wikipedia, 32MalaCards
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Wikipedia:63 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

MalaCards: Central Retinal Artery Occlusion is related to retinal vein occlusion and central retinal vein occlusion. An important gene associated with Central Retinal Artery Occlusion is SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10), and among its related pathways are Platelet activation, signaling and aggregation and Dissolution of Fibrin Clot. The compounds warfarin and aspartate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Central Retinal Artery Occlusion

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

central retinal artery occlusion 8 10 60


External Ids:

Disease Ontology8 DOID:13098
MeSH34 D015356
NCIt39 C34456
SNOMED-CT56 38742007
ICD9CM27 362.31
ICD1025 H34.1

Related Diseases for Central Retinal Artery Occlusion

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Central Retinal Artery Occlusion family:

Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vein occlusion30.9F5, MTHFR, SERPINC1
2central retinal vein occlusion30.9F5, PLAT, MTHFR
3lupus erythematosus30.8SERPINC1, F2, F5
4sickle cell disease30.8HMOX1
5branch retinal artery occlusion30.8PSD, F5
6vasculitis30.7F2
7migraine30.5MTHFR
8patent foramen ovale30.5F5
9retinal vascular occlusion30.5F5
10ischemia30.5PLAT, HMOX1
11homocystinuria30.5F5, MTHFR, SERPINC1
12protein s deficiency30.5F5, MTHFR, F2, SERPINE1, SERPINC1
13hyperhomocysteinemia30.5SERPINC1, SERPINE1, PLAT, F2, MTHFR, F5
14purpura30.3SERPINC1
15pneumonia30.3HMOX1
16sneddon syndrome30.3SERPINC1
17ovarian hyperstimulation syndrome30.3F5
18endophthalmitis30.3PLAT
19hemorrhagic disease30.3F5, F2, SERPINC1
20antiphospholipid syndrome30.2F5, MTHFR, F2, PLAT, SERPINC1
21myocardial infarction30.2ITGB3, F5, MTHFR, PLAT, SERPINE1, SERPINC1
22retinal artery occlusion11.5
23retinitis11.5
24retinal disease10.9
25neuropathy10.8
26carotid artery occlusion10.8
27ischemic neuropathy10.6
28transient retinal arterial occlusion10.6
29churg-strauss syndrome10.6
30ischemic optic neuropathy10.6
31glaucoma10.6
32systemic lupus erythematosus10.6
33wegener's granulomatosis10.6
34retinal drusen10.5
35cerebral artery occlusion10.5
36cerebritis10.5
37herpes zoster10.5
38retinal vasculitis10.5
39neovascular glaucoma10.4
40choroiditis10.4
41orbital cellulitis10.4
42cellulitis10.4
43carotid artery dissection10.4
44carotid artery disease10.4
45tuberculosis10.4
46partial arterial retinal occlusion10.4
47retinal ischemia10.4
48polyarteritis nodosa10.4
49cervicitis10.4
50ophthalmoplegia10.4

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to central retinal artery occlusion

Clinical Features for Central Retinal Artery Occlusion

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Drugs & Therapeutics for Central Retinal Artery Occlusion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Retinal Artery Occlusion

Drug clinical trials:

Search ClinicalTrials for Central Retinal Artery Occlusion

Search NIH Clinical Center for Central Retinal Artery Occlusion

Search CenterWatch for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

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Anatomical Context for Central Retinal Artery Occlusion

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32MalaCards
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MalaCards organs/tissues related to Central Retinal Artery Occlusion:

32
Eye, Retina, Brain, T cells

Animal Models for Central Retinal Artery Occlusion or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Central Retinal Artery Occlusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.3ITGB3
2MP:00107719.5EMILIN1, F2, SLC17A8
3MP:00053899.2SERPINC1, HMOX1, MTHFR, ITGB3
4MP:00053859.0SERPINA10, HMOX1, F2, EMILIN1, ITGB3
5MP:00053708.5ITGB3, F5, HMOX1, SERPINE1, SERPINC1
6MP:00053767.3ITGB3, F5, MTHFR, F2, PLAT, HMOX1
7MP:00036317.3F5, MTHFR, F2, PLAT, THY1, SLC17A8
8MP:00107687.1ITGB3, F5, MTHFR, F2, PLAT, HMOX1

Publications for Central Retinal Artery Occlusion

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50PubMed
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Articles related to Central Retinal Artery Occlusion:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Ischaemia-reperfusion injury in central retinal artery occlusion. (24145508)
2013
2
Unilateral central retinal artery occlusion as the sole presenting sign of Susac syndrome in a young man: case report. (23929083)
2013
3
Isolated central retinal artery occlusion as an initial presentation of paroxysmal nocturnal hemoglobinuria and successful long-term prevention of systemic thrombosis with eculizumab. (23765390)
2013
4
DWI findings of optic nerve ischemia in the setting of central retinal artery occlusion. (21699599)
2013
5
Treatment options for central retinal artery occlusion. (23070637)
2013
6
Cystoid macular edema in acute presentation of central retinal artery occlusion. (22606497)
2012
7
Sequential bilateral central retinal artery occlusion as the primary manifestation of systemic lupus erythematosus. (22613664)
2012
8
Combined central retinal artery and vein occlusion secondary to cataract surgery in a patient with persistent hyaloid artery. (24269395)
2012
9
Efficacy of intravenous tissue-type plasminogen activator in central retinal artery occlusion: report from a randomized, controlled trial. (21757667)
2011
10
Combined optic neuropathy and central retinal artery occlusion in presumed ocular tuberculosis without detectable systemic infection. (21834697)
2011
11
Combined cilioretinal artery and central retinal vein occlusion treated with a single injection of Ranibizumab. (21484666)
2011
12
Translation of clinical studies to clinical practice: survey on the treatment of central retinal artery occlusion. (19540987)
2009
13
Peribulbar anesthesia leading to central retinal artery occlusion. (19502037)
2009
14
Intravenous tissue plasminogen activator in central retinal artery occlusion. (19463547)
2009
15
Central retinal artery occlusion: timing and mode of presentation. (19374663)
2009
16
Branch retinal vein occlusion followed by central retinal artery occlusion in Churg-Strauss syndrome: unusual ocular manifestations in allergic granulomatous angiitis. (19253257)
2009
17
A case of subperiosteal abscess of the orbit with central retinal artery occlusion. (19253249)
2009
18
Intravenous thrombolysis with low-dose recombinant tissue plasminogen activator in central retinal artery occlusion. (18718570)
2008
19
The Association between Dominant Macular Drusen and Central Retinal Artery Occlusion in Young Females with Cardiac Valve Disease. (21369470)
2008
20
Fundus changes in central retinal artery occlusion. (17460582)
2007
21
Traumatic optic nerve avulsion and central retinal artery occlusion following rugby injury. (16451269)
2006
22
Recovery of vision after bilateral arteritic central retinal artery occlusion. (15068446)
2004
23
Predominant loss of the photopic negative response in central retinal artery occlusion. (15126164)
2004
24
Accelerated reperfusion of poorly perfused retinal areas in central retinal artery occlusion and branch retinal artery occlusion after a short treatment with enhanced external counterpulsation. (15300074)
2004
25
Selective intraarterial fibrinolysis of acute central retinal artery occlusion. (14616215)
2003
26
Transient central retinal artery occlusion after posterior sub-Tenon's anesthesia. (14522307)
2003
27
Chlamydia pneumoniae in central retinal artery occlusion. (12485289)
2002
28
Oral contraceptive-induced central retinal artery occlusion. (12421041)
2002
29
Branch retinal artery obstruction with simultaneous central retinal vein occlusion. (11339596)
2001
30
Central retinal artery occlusion as the initial sign of aortic valve papillary fibroelastoma. (11336952)
2001
31
Vitreous surgery for central retinal artery occlusion. (11074821)
2000
32
Trabeculectomy for central retinal artery occlusion. (10845034)
2000
33
Plasma lipoprotein(a) levels are high in patients with central retinal artery occlusion. (9736419)
1998
34
Redistribution of GABA immunoreactivity following central retinal artery occlusion. (7552261)
1995
35
Postpartum central retinal artery occlusion simulating Purtscher's retinopathy. (7715926)
1995
36
Central retinal artery occlusion in a child with T-cell lymphoma. (7611320)
1995
37
Toxoplasmic papillitis with central retinal artery occlusion. (8963940)
1995
38
Intra-arterial fibrinolytic therapy in central retinal artery occlusion. (8278042)
1993
39
Homocystinuria presenting as central retinal artery occlusion and longstanding thromboembolic disease. (2223710)
1990
40
Migrainous central retinal artery occlusion. (2942572)
1986
41
Central retinal artery occlusion associated with periocular corticosteroid injection for juvenile hemangioma. (3714192)
1986
42
Emergent treatment of central retinal artery occlusion caused by embolism. (6878717)
1983
43
Ocular neovascularization with retinal vascular occlusion. II. Occurrence in central and branch retinal artery occlusion. (6182865)
1982
44
Salmon-patch hemorrhages after central retinal artery occlusion in sickle cell disease. (7469857)
1981
45
Central retinal artery occlusion following cosmetic blepharoplasty. (7448145)
1980
46
Carotid artery disease and central retinal artery occlusion. (436273)
1979
47
Anterior chamber paracentesis in the management of acute nonarteritic central retinal artery occlusion. (617526)
1977
48
Traumatic central retinal artery occlusion with sickle cell trait. (1180306)
1975
49
Sickle-cell trait and central retinal-artery occlusion. (6019533)
1967
50
Central retinal artery occlusion associated with cryoglobulinemia. (13410214)
1957

Genetic Variations for Central Retinal Artery Occlusion

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Expression for genes affiliated with Central Retinal Artery Occlusion

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for genes affiliated with Central Retinal Artery Occlusion

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Sources:
53Reactome, 51QIAGEN, 4Cell Signaling Technology, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG
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Compounds for genes affiliated with Central Retinal Artery Occlusion

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.6SERPINC1
2aspartate4410.4F2
3heparin44 28 11 2413.2SERPINA10, MTHFR
4serine4410.1SERPINA10
5creatinine449.9F5, F2
6inogatran449.7F2, SERPINC1, F5
7ecarin449.7F5, SERPINC1, F2
8hirugen449.7SERPINC1, F2, F5
9danaparoid449.7F5, SERPINC1, F2
10ximelagatran44 1110.7F5, F2, SERPINC1
11heparinoids449.7SERPINC1, F5, F2
12fibrinopeptide a449.6SERPINC1, F2, PLAT
13desogestrel44 1110.6F5, SERPINC1, F2
14eaca449.6PLAT, SERPINC1, SERPINE1
15p-amino benzamidine449.6PLAT, SERPINC1, SERPINE1
16Drotrecogin alfa119.6F2, SERPINE1, F5
17ppack449.5SERPINC1, PLAT, F2
18gestodene44 1110.5SERPINC1, F5, F2
19tirofiban44 1110.4PLAT, SERPINC1, F2, ITGB3
20abciximab44 1110.4SERPINC1, ITGB3, PLAT, F2
21clopidogrel49 44 11 2412.4SERPINC1, PLAT, F2, ITGB3
22gabexate mesilate449.4SERPINC1, PLAT, F5
23tranexamic acid44 1110.3F2, SERPINE1, PLAT, SERPINC1
24tibolone449.3SERPINC1, SERPINE1, F5
25epsilon aminocaproic acid449.3PLAT, F2, SERPINC1, SERPINE1
26spectrozyme449.3PLAT, SERPINC1, F2, F5
27fondaparinux449.3F5, PLAT, SERPINC1, F2
28bivalirudin44 1110.3F2, SERPINC1, F5, PLAT
29argatroban44 1110.3SERPINC1, F5, PLAT, F2
30protamine sulfate449.2PLAT, F5, F2, SERPINC1
31batroxobin449.2F5, F2, PLAT, SERPINE1
32levonorgestrel44 59 28 1112.2PLAT, SERPINC1, F2, F5
33aprotinin44 1110.2F5, SERPINC1, SERPINE1, PLAT
34dermatan sulfate449.1SERPINC1, F5, F2, PLAT
35polyethylene glycol449.1F2, F5, SERPINC1, HMOX1
36ristocetin449.0F5, F2, ITGB3, PLAT, SERPINC1
37pge1448.9PLAT, SERPINE1, F2, F5
38ancrod448.9PLAT, F5, F2, SERPINC1, SERPINE1
39desmopressin44 59 28 1111.9PLAT, SERPINE1, SERPINC1, F5, F2
40hirudin448.9F5, SERPINC1, SERPINE1, PLAT, F2
41protamine448.9SERPINC1, F2, SERPINE1, F5, PLAT
42kininogen448.9F5, SERPINC1, SERPINE1, PLAT, F2
43simvastatin44 49 59 28 11 2413.8SERPINE1, HMOX1, PLAT, F2, F5
44prostacyclin448.8PLAT, HMOX1, SERPINE1, SERPINC1, F5
45ascorbic acid44 249.5SERPINC1, F5, MTHFR, PLAT, HMOX1
46atorvastatin44 49 28 11 2412.5F5, PLAT, HMOX1, SERPINE1
47homocysteine44 249.5F5, MTHFR, F2, PLAT, SERPINC1, SERPINE1
48alanine448.4ITGB3, SERPINC1, F5, F2, HMOX1, SERPINA10
49fibrinogen448.2SERPINE1, ITGB3, SERPINC1, PLAT, F2, MTHFR
50aspirin44 49 28 2410.9SERPINE1, HMOX1, F2, MTHFR, F5, ITGB3

GO Terms for genes affiliated with Central Retinal Artery Occlusion

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16Gene Ontology
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Cellular components related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1SERPINE1, PLAT, EMILIN1
2extracellular spaceGO:0056157.8SERPINC1, F5, F2, PLAT, HMOX1, SERPINA10
3extracellular regionGO:0055767.6F5, EMILIN1, F2, PLAT, SERPINE1, SERPINC1

Biological processes related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.9HMOX1, SERPINE1
2smooth muscle cell migrationGO:0149099.9PLAT, ITGB3
3negative regulation of fibrinolysisGO:0519189.8F2, SERPINE1
4negative regulation of endopeptidase activityGO:0109519.7SERPINA10, SERPINE1, SERPINC1
5positive regulation of blood coagulationGO:0301949.7SERPINE1, F2
6negative regulation of proteolysisGO:0458619.6PLAT, F2
7platelet degranulationGO:0025769.5SERPINE1, F5, ITGB3
8fibrinolysisGO:0427309.5F2, PLAT, SERPINE1
9platelet activationGO:0301689.2SERPINE1, F2, F5, ITGB3
10positive regulation of release of sequestered calcium ion into cytosolGO:0512819.2THY1, F2
11blood coagulationGO:0075968.2SERPINC1, SERPINE1, SERPINA10, PLAT, F2, F5

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.5SERPINC1, SERPINE1, SERPINA10

Products for genes affiliated with Central Retinal Artery Occlusion

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  • Antibodies
  • Proteins
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Sources for Central Retinal Artery Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet