MCID: CNT028
MIFTS: 52

Central Retinal Artery Occlusion malady

Eye diseases, Cardiovascular diseases categories

Summaries for Central Retinal Artery Occlusion

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66Wikipedia, 34MalaCards
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Wikipedia:66 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

MalaCards: Central Retinal Artery Occlusion is related to lupus erythematosus and retinal vein occlusion. An important gene associated with Central Retinal Artery Occlusion is SLC17A8 (solute carrier family 17 (vesicular glutamate transporter), member 8), and among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Integrin alphaIIb beta3 signaling. The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Central Retinal Artery Occlusion

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9Disease Ontology, 11DISEASES, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Cardiovascular diseases


Aliases & Descriptions:

central retinal artery occlusion 9 11 63


External Ids:

Disease Ontology9 DOID:13098
MeSH36 D015356
NCIt41 C34456
SNOMED-CT59 38742007
ICD9CM28 362.31
ICD1026 H34.1

Related Diseases for Central Retinal Artery Occlusion

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18GeneCards, 19GeneDecks
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Diseases in the Central Retinal Artery Occlusion family:

Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus31.0F5, SERPINC1, F2
2retinal vein occlusion30.8F5, MTHFR, SERPINC1
3branch retinal artery occlusion30.7F5
4protein s deficiency30.6F5, SERPINC1
5homocystinuria30.6SERPINC1, F5, MTHFR
6sneddon syndrome30.5SERPINC1
7central retinal vein occlusion30.5F5, PLAT, MTHFR
8purpura30.5SERPINC1
9endophthalmitis30.4PLAT
10hyperhomocysteinemia30.3SERPINC1, F5, MTHFR, SERPINE1, F2, PLAT
11antiphospholipid syndrome30.2F5, MTHFR, PLAT, SERPINC1, F2
12myocardial infarction30.1MTHFR, ITGB3, F5, SERPINE1, SERPINC1, PLAT
13thromboembolism30.1F2, SERPINE1, SERPINC1, MTHFR, PLAT, F5
14retinal artery occlusion11.5
15retinitis11.5
16neuropathy10.8
17churg-strauss syndrome10.7
18anterior ischemic optic neuropathy10.6
19glaucoma10.6
20systemic lupus erythematosus10.6
21wegener's granulomatosis10.6
22herpes zoster10.5
23cerebritis10.5
24vasculitis10.5
25sickle cell disease10.5
26blindness10.5
27neovascular glaucoma10.5
28choroiditis10.5
29orbital cellulitis10.5
30cellulitis10.5
31tuberculosis10.5
32herpes zoster ophthalmicus10.5
33carotid artery dissection10.4
34polyarteritis nodosa10.4
35patent foramen ovale10.4
36artery disease10.4
37carotid artery disease10.4
38cervicitis10.4
39ischemia10.4
40migraine10.4
41ophthalmoplegia10.4
42fibromuscular dysplasia10.4
43susac syndrome10.4
44aneurysm10.4
45mononeuritis multiplex10.2
46pseudoxanthoma elasticum10.2
47granulomatous angiitis10.2
48pulmonary tuberculosis10.2
49cryoglobulinemia10.2
50non-arteritic anterior ischemic optic neuropathy10.2

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to central retinal artery occlusion

Symptoms for Central Retinal Artery Occlusion

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Drugs & Therapeutics for Central Retinal Artery Occlusion

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Retinal Artery Occlusion

Drug clinical trials:

Search ClinicalTrials for Central Retinal Artery Occlusion

Search NIH Clinical Center for Central Retinal Artery Occlusion

Search CenterWatch for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

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Anatomical Context for Central Retinal Artery Occlusion

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34MalaCards
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MalaCards organs/tissues related to Central Retinal Artery Occlusion:

34
Eye, Retina, Brain, T cells

Animal Models for Central Retinal Artery Occlusion or affiliated genes

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Sources:
38MGI
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Publications for Central Retinal Artery Occlusion

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Sources:
53PubMed
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Articles related to Central Retinal Artery Occlusion:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Unilateral central retinal artery occlusion as the sole presenting sign of Susac syndrome in a young man: case report. (24232952)
2013
2
Acute, bilateral, concurrent central retinal artery occlusion in sickle cell disease after use of tadalafil (Cialis). (24052082)
2013
3
Surgical embolectomy for central retinal artery occlusion. (23561615)
2013
4
Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion. (23619503)
2013
5
Central retinal artery occlusion caused by fat embolism following endoscopic sinus surgery. (23571187)
2013
6
Carbogen in the management of a central retinal artery occlusion. (23256429)
2012
7
ANCA-associated vasculitis with central retinal artery occlusion developing during treatment with methimazole. (23154728)
2012
8
Comparison of optical coherence tomography findings in a patient with central retinal artery occlusion in one eye and end-stage glaucoma in the fellow eye. (22623869)
2012
9
Central retinal artery occlusion treated with oxygen: a literature review and treatment algorithm. (23045923)
2012
10
Traumatic optic neuropathy and central retinal artery occlusion following blunt ocular trauma. (22043273)
2011
11
Central retinal artery occlusion resembling Purtscher-like retinopathy. (21847341)
2011
12
Lesions of the mitral valve as a cause of central retinal artery occlusion: presentation and discussion of two cases. (20070361)
2010
13
Teaching NeuroImages: central retinal artery occlusion with cilioretinal artery sparing in giant cell arteritis. (20679629)
2010
14
Sequential central retinal artery occlusion and retinal vein stasis as a result of ocular ischemic syndrome. (20408094)
2010
15
Translation of clinical studies to clinical practice: survey on the treatment of central retinal artery occlusion. (19540987)
2009
16
Thrombolytic therapy in central retinal artery occlusion: cutting edge therapy, standard of care therapy, or impractical therapy? (19367164)
2009
17
Molecular and histological changes following central retinal artery occlusion in a mouse model. (18639547)
2008
18
Central retinal artery occlusion following transcatheter balloon aortic valvuloplasty in an adolescent with aortic valvular stenosis. (18094913)
2008
19
Systemic diseases in non-inflammatory branch and central retinal artery occlusion--an overview of 416 patients. (18024271)
2007
20
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
21
An unusual cause of central retinal artery occlusion: acquired immunodeficiency syndrome. (17671949)
2007
22
Intra-arterial thrombolysis for central retinal artery occlusion in United States: Nationwide In-patient Survey 2001-2003. (17894624)
2007
23
Central retinal artery occlusion in an ANCA negative Churg-Strauss syndrome patient. (17522782)
2007
24
Ocular ischemic syndrome presenting as central retinal artery occlusion in scleroderma. (16395147)
2006
25
Central retinal artery occlusion: association with patent foramen ovale. (15999129)
2006
26
Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. (15654031)
2005
27
Neodymium:yttrium-aluminum-garnet laser arteriotomy with embolectomy for central retinal artery occlusion. (14700675)
2004
28
Recovery of vision after bilateral arteritic central retinal artery occlusion. (15068446)
2004
29
Selective intraarterial fibrinolysis of acute central retinal artery occlusion. (14616215)
2003
30
Chlamydia pneumoniae in central retinal artery occlusion. (12485289)
2002
31
Henoch-Schonlein purpura with bilateral central retinal artery occlusion. (11864898)
2002
32
Interventions for acute non-arteritic central retinal artery occlusion. (11869617)
2002
33
Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: an experimental study in rhesus monkeys. (10926989)
2000
34
Central retinal artery occlusion in a patient homozygous for factor V Leiden. (10927002)
2000
35
Ocular massage in a case of central retinal artery occlusion the successful treatment of a hitherto undescribed type of embolism. (10799350)
2000
36
Characteristics of patients presenting with central retinal artery occlusion with and without giant cell arteritis. (11192446)
2000
37
Central retinal artery occlusion and bilateral choroidal infarcts in Wegener's granulomatosis. (10624439)
1999
38
A case of central retinal artery occlusion after carotid endoarterectomy. (9474333)
1997
39
Peripheral thrombolytic therapy for central retinal artery occlusion. CRAO Study Group. (7661736)
1995
40
Central retinal artery occlusion after varicella. (1642311)
1992
41
Convulsions, hemiparesis and central retinal artery occlusion due to left atrial myxoma in child. (1396924)
1992
42
Central retinal artery occlusion in a child after general anesthesia. (1882928)
1991
43
Delayed filling of retinal and ciliary circulation after central retinal artery occlusion. (3060337)
1988
44
Emergent treatment of central retinal artery occlusion caused by embolism. (6878717)
1983
45
Treatment of acute central-retinal-artery occlusion. (82689)
1978
46
Central retinal artery occlusion (reversible in sickle trait with glaucoma. (952815)
1976
47
Central retinal artery occlusion. (1121994)
1975
48
Early diagnosis of an atrial myxoma with central retinal artery occlusion. (4429326)
1974
49
Central retinal artery occlusion associated with cryoglobulinemia. (13410214)
1957
50
Bilateral central retinal artery occlusion; occurrence in a patient with cortisone-treated systemic lupus erythematosus, sickle cell trait, and active pulmonary tuberculosis. (13257998)
1955

Variations for Central Retinal Artery Occlusion

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Expression for genes affiliated with Central Retinal Artery Occlusion

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for genes affiliated with Central Retinal Artery Occlusion

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Sources:
51PathCards, 52PharmGKB, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 5Cell Signaling Technology, 31KEGG, 55R&D Systems
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Pathways related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGB3, F2
2
Show member pathways
9.7ITGB3, F2
39.3THY1, PLAT
49.3ITGB3, SERPINE1
5
Show member pathways
9.2F2, SERPINC1, F5
69.0PLAT, SERPINE1
7
Show member pathways
8.9F5, ITGB3, SERPINE1
88.8THY1, SERPINE1, ITGB3
9
Show member pathways
8.4F2, THY1, SERPINE1, ITGB3
10
Show member pathways
thioredoxin pathway39
8.1PLAT, MTHFR, SERPINE1, F2
11
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
7.8F2, SERPINE1, SERPINC1, PLAT, F5
12
Show member pathways
7.8F5, PLAT, SERPINC1, SERPINE1, F2
13
Show member pathways
7.4F2, SERPINE1, SERPINC1, ITGB3, PLAT, F5

Compounds for genes affiliated with Central Retinal Artery Occlusion

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1inogatran469.6F5, SERPINC1, F2
2hirugen469.6F2, F5, SERPINC1
3ecarin469.6F5, SERPINC1, F2
4danaparoid469.5F2, SERPINC1, F5
5ximelagatran46 1210.5F2, SERPINC1, F5
6heparinoids469.5F2, SERPINC1, F5
7desogestrel46 1210.4F5, F2, SERPINC1
8fibrinopeptide a469.4F2, PLAT, SERPINC1
9gestodene46 1210.3F5, SERPINC1, F2
10ppack469.2F2, SERPINC1, PLAT
11gabexate mesilate469.2PLAT, SERPINC1, F5
12tirofiban46 1210.1F2, SERPINC1, PLAT, ITGB3
13abciximab46 1210.1ITGB3, PLAT, SERPINC1, F2
14clopidogrel46 52 25 1212.1F2, SERPINC1, ITGB3, PLAT
15spectrozyme469.1F5, PLAT, SERPINC1, F2
16fondaparinux469.0F5, SERPINC1, F2, PLAT
17bivalirudin46 1210.0F2, SERPINC1, PLAT, F5
18argatroban46 1210.0SERPINC1, F5, PLAT, F2
19polyethylene glycol469.0F2, SERPINC1, F5, HMOX1
20protamine sulfate469.0SERPINC1, F2, PLAT, F5
21levonorgestrel46 62 30 1212.0PLAT, SERPINC1, F2, F5
22eaca469.0SERPINE1, PLAT, SERPINC1
23p-amino benzamidine468.9SERPINC1, PLAT, SERPINE1
24dermatan sulfate468.9F2, SERPINC1, PLAT, F5
25tibolone468.8SERPINE1, SERPINC1, F5
26ristocetin468.7F2, F5, PLAT, ITGB3, SERPINC1
27tranexamic acid46 129.7F2, SERPINE1, SERPINC1, PLAT
28epsilon aminocaproic acid468.6PLAT, SERPINC1, F2, SERPINE1
29batroxobin468.6F5, PLAT, F2, SERPINE1
30warfarin46 52 25 1211.5SERPINC1, F5, PLAT, MTHFR, F2
31ascorbic acid46 259.4SERPINC1, MTHFR, PLAT, F5, HMOX1
32pge1468.4F2, PLAT, F5, SERPINE1
33ancrod468.2PLAT, SERPINC1, SERPINE1, F2, F5
34prostacyclin468.2SERPINC1, SERPINE1, PLAT, F5, HMOX1
35desmopressin46 62 30 1211.2F5, PLAT, SERPINC1, SERPINE1, F2
36hirudin468.2SERPINC1, PLAT, SERPINE1, F5, F2
37simvastatin46 52 62 30 25 1213.2SERPINE1, F2, PLAT, F5, HMOX1
38protamine468.2F5, PLAT, SERPINC1, SERPINE1, F2
39kininogen468.2F5, PLAT, SERPINC1, SERPINE1, F2
40aprotinin46 129.2SERPINE1, SERPINC1, F2, F5, PLAT
41alanine468.0MTHFR, F5, HMOX1, F2, SERPINC1, ITGB3
42atorvastatin46 52 30 25 1212.0HMOX1, SERPINE1, F5, PLAT
43homocysteine46 258.7F2, SERPINE1, SERPINC1, F5, MTHFR, PLAT
44aspartate467.6ITGB3, PLAT, SERPINE1, F5, F2, MTHFR
45creatinine467.6F5, MTHFR, PLAT, SERPINC1, SERPINE1, F2
46heparin46 30 25 1210.6F5, F2, PLAT, MTHFR, SERPINC1, SERPINE1
47estrogen467.6ITGB3, F2, F5, SERPINC1, SERPINE1, MTHFR
48fibrinogen467.4ITGB3, F2, F5, PLAT, MTHFR, SERPINC1
49aspirin46 52 30 2510.1HMOX1, F5, PLAT, ITGB3, MTHFR, SERPINC1
50serine466.8SERPINE1, SERPINC1, MTHFR, ITGB3, F2, PLAT

GO Terms for genes affiliated with Central Retinal Artery Occlusion

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17Gene Ontology
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Cellular components related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2F5, SERPINE1
2extracellular regionGO:0055767.7F2, SERPINE1, SERPINC1, PLAT, F5
3extracellular spaceGO:0056157.5HMOX1, F5, PLAT, SERPINC1, SERPINE1, F2
4plasma membraneGO:0058867.2F2, THY1, SERPINE1, SERPINC1, ITGB3, F5

Biological processes related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:0149099.7PLAT, ITGB3
2negative regulation of proteolysisGO:0458619.5PLAT, F2
3blood circulationGO:0080159.5F5, MTHFR
4positive regulation of release of sequestered calcium ion into cytosolGO:0512819.4THY1, F2
5negative regulation of fibrinolysisGO:0519189.4SERPINE1, F2
6positive regulation of blood coagulationGO:0301949.4SERPINE1, F2
7negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.3SERPINE1, HMOX1
8platelet degranulationGO:0025769.0SERPINE1, ITGB3, F5
9fibrinolysisGO:0427308.9F2, SERPINE1, PLAT
10platelet activationGO:0301688.7F5, ITGB3, SERPINE1, F2
11angiogenesisGO:0015258.5HMOX1, SERPINE1, THY1
12blood coagulationGO:0075967.7F5, PLAT, ITGB3, SERPINC1, SERPINE1, F2

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042528.7F5, PLAT, F2
2protein bindingGO:0055156.9THY1, SERPINE1, SERPINC1, ITGB3, PLAT, F5

Products for genes affiliated with Central Retinal Artery Occlusion

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  • Antibodies
  • Proteins
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Sources for Central Retinal Artery Occlusion

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet