MCID: CNT028
MIFTS: 52

Central Retinal Artery Occlusion malady

Eye diseases, Cardiovascular diseases categories
Download this MalaCard

Summaries for Central Retinal Artery Occlusion

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

MalaCards: Central Retinal Artery Occlusion is related to lupus erythematosus and retinal vein occlusion. An important gene associated with Central Retinal Artery Occlusion is SLC17A8 (solute carrier family 17 (vesicular glutamate transporter), member 8), and among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Integrin alphaIIb beta3 signaling. The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Central Retinal Artery Occlusion

About this section
Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Cardiovascular diseases


Aliases & Descriptions:

central retinal artery occlusion 8 10 62


External Ids:

Disease Ontology8 DOID:13098
MeSH35 D015356
NCIt40 C34456
SNOMED-CT58 38742007
ICD9CM27 362.31
ICD1025 H34.1

Related Diseases for Central Retinal Artery Occlusion

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Central Retinal Artery Occlusion family:

Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus31.0F5, SERPINC1, F2
2retinal vein occlusion30.8F5, MTHFR, SERPINC1
3branch retinal artery occlusion30.7F5
4protein s deficiency30.6F5, SERPINC1
5homocystinuria30.6SERPINC1, F5, MTHFR
6sneddon syndrome30.5SERPINC1
7central retinal vein occlusion30.5F5, PLAT, MTHFR
8purpura30.5SERPINC1
9endophthalmitis30.4PLAT
10hyperhomocysteinemia30.3SERPINC1, F5, MTHFR, SERPINE1, F2, PLAT
11antiphospholipid syndrome30.2F5, MTHFR, PLAT, SERPINC1, F2
12myocardial infarction30.1MTHFR, ITGB3, F5, SERPINE1, SERPINC1, PLAT
13thromboembolism30.1F2, SERPINE1, SERPINC1, MTHFR, PLAT, F5
14retinal artery occlusion11.5
15retinitis11.5
16neuropathy10.8
17churg-strauss syndrome10.7
18anterior ischemic optic neuropathy10.6
19glaucoma10.6
20systemic lupus erythematosus10.6
21wegener's granulomatosis10.6
22herpes zoster10.5
23cerebritis10.5
24vasculitis10.5
25sickle cell disease10.5
26blindness10.5
27neovascular glaucoma10.5
28choroiditis10.5
29orbital cellulitis10.5
30cellulitis10.5
31tuberculosis10.5
32herpes zoster ophthalmicus10.5
33carotid artery dissection10.4
34polyarteritis nodosa10.4
35patent foramen ovale10.4
36artery disease10.4
37carotid artery disease10.4
38cervicitis10.4
39ischemia10.4
40migraine10.4
41ophthalmoplegia10.4
42fibromuscular dysplasia10.4
43susac syndrome10.4
44aneurysm10.4
45mononeuritis multiplex10.2
46pseudoxanthoma elasticum10.2
47granulomatous angiitis10.2
48pulmonary tuberculosis10.2
49cryoglobulinemia10.2
50non-arteritic anterior ischemic optic neuropathy10.2

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to central retinal artery occlusion

Symptoms for Central Retinal Artery Occlusion

About this section

Drugs & Therapeutics for Central Retinal Artery Occlusion

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Central Retinal Artery Occlusion

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

About this section

Anatomical Context for Central Retinal Artery Occlusion

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Central Retinal Artery Occlusion:

33
Eye, Retina, Brain, T cells

Animal Models for Central Retinal Artery Occlusion or affiliated genes

About this section
Sources:
37MGI
See all sources

Publications for Central Retinal Artery Occlusion

About this section
Sources:
52PubMed
See all sources

Articles related to Central Retinal Artery Occlusion:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Unilateral central retinal artery occlusion as the sole presenting sign of Susac syndrome in a young man: case report. (24232952)
2013
2
Acute, bilateral, concurrent central retinal artery occlusion in sickle cell disease after use of tadalafil (Cialis). (24052082)
2013
3
Surgical embolectomy for central retinal artery occlusion. (23561615)
2013
4
Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion. (23619503)
2013
5
Central retinal artery occlusion caused by fat embolism following endoscopic sinus surgery. (23571187)
2013
6
Carbogen in the management of a central retinal artery occlusion. (23256429)
2012
7
ANCA-associated vasculitis with central retinal artery occlusion developing during treatment with methimazole. (23154728)
2012
8
Comparison of optical coherence tomography findings in a patient with central retinal artery occlusion in one eye and end-stage glaucoma in the fellow eye. (22623869)
2012
9
Central retinal artery occlusion treated with oxygen: a literature review and treatment algorithm. (23045923)
2012
10
Traumatic optic neuropathy and central retinal artery occlusion following blunt ocular trauma. (22043273)
2011
11
Central retinal artery occlusion resembling Purtscher-like retinopathy. (21847341)
2011
12
Lesions of the mitral valve as a cause of central retinal artery occlusion: presentation and discussion of two cases. (20070361)
2010
13
Teaching NeuroImages: central retinal artery occlusion with cilioretinal artery sparing in giant cell arteritis. (20679629)
2010
14
Sequential central retinal artery occlusion and retinal vein stasis as a result of ocular ischemic syndrome. (20408094)
2010
15
Translation of clinical studies to clinical practice: survey on the treatment of central retinal artery occlusion. (19540987)
2009
16
Thrombolytic therapy in central retinal artery occlusion: cutting edge therapy, standard of care therapy, or impractical therapy? (19367164)
2009
17
Molecular and histological changes following central retinal artery occlusion in a mouse model. (18639547)
2008
18
Central retinal artery occlusion following transcatheter balloon aortic valvuloplasty in an adolescent with aortic valvular stenosis. (18094913)
2008
19
Systemic diseases in non-inflammatory branch and central retinal artery occlusion--an overview of 416 patients. (18024271)
2007
20
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
21
An unusual cause of central retinal artery occlusion: acquired immunodeficiency syndrome. (17671949)
2007
22
Intra-arterial thrombolysis for central retinal artery occlusion in United States: Nationwide In-patient Survey 2001-2003. (17894624)
2007
23
Central retinal artery occlusion in an ANCA negative Churg-Strauss syndrome patient. (17522782)
2007
24
Ocular ischemic syndrome presenting as central retinal artery occlusion in scleroderma. (16395147)
2006
25
Central retinal artery occlusion: association with patent foramen ovale. (15999129)
2006
26
Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. (15654031)
2005
27
Neodymium:yttrium-aluminum-garnet laser arteriotomy with embolectomy for central retinal artery occlusion. (14700675)
2004
28
Recovery of vision after bilateral arteritic central retinal artery occlusion. (15068446)
2004
29
Selective intraarterial fibrinolysis of acute central retinal artery occlusion. (14616215)
2003
30
Chlamydia pneumoniae in central retinal artery occlusion. (12485289)
2002
31
Henoch-Schonlein purpura with bilateral central retinal artery occlusion. (11864898)
2002
32
Interventions for acute non-arteritic central retinal artery occlusion. (11869617)
2002
33
Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: an experimental study in rhesus monkeys. (10926989)
2000
34
Central retinal artery occlusion in a patient homozygous for factor V Leiden. (10927002)
2000
35
Ocular massage in a case of central retinal artery occlusion the successful treatment of a hitherto undescribed type of embolism. (10799350)
2000
36
Characteristics of patients presenting with central retinal artery occlusion with and without giant cell arteritis. (11192446)
2000
37
Central retinal artery occlusion and bilateral choroidal infarcts in Wegener's granulomatosis. (10624439)
1999
38
A case of central retinal artery occlusion after carotid endoarterectomy. (9474333)
1997
39
Peripheral thrombolytic therapy for central retinal artery occlusion. CRAO Study Group. (7661736)
1995
40
Central retinal artery occlusion after varicella. (1642311)
1992
41
Convulsions, hemiparesis and central retinal artery occlusion due to left atrial myxoma in child. (1396924)
1992
42
Central retinal artery occlusion in a child after general anesthesia. (1882928)
1991
43
Delayed filling of retinal and ciliary circulation after central retinal artery occlusion. (3060337)
1988
44
Emergent treatment of central retinal artery occlusion caused by embolism. (6878717)
1983
45
Treatment of acute central-retinal-artery occlusion. (82689)
1978
46
Central retinal artery occlusion (reversible in sickle trait with glaucoma. (952815)
1976
47
Central retinal artery occlusion. (1121994)
1975
48
Early diagnosis of an atrial myxoma with central retinal artery occlusion. (4429326)
1974
49
Central retinal artery occlusion associated with cryoglobulinemia. (13410214)
1957
50
Bilateral central retinal artery occlusion; occurrence in a patient with cortisone-treated systemic lupus erythematosus, sickle cell trait, and active pulmonary tuberculosis. (13257998)
1955

Variations for Central Retinal Artery Occlusion

About this section

Expression for genes affiliated with Central Retinal Artery Occlusion

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for genes affiliated with Central Retinal Artery Occlusion

About this section
Sources:
50PathCards, 51PharmGKB, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 5Cell Signaling Technology, 30KEGG, 54R&D Systems
See all sources

Pathways related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGB3, F2
2
Show member pathways
9.7ITGB3, F2
39.3THY1, PLAT
49.3ITGB3, SERPINE1
5
Show member pathways
9.2F2, SERPINC1, F5
69.0PLAT, SERPINE1
7
Show member pathways
8.9F5, ITGB3, SERPINE1
88.8THY1, SERPINE1, ITGB3
9
Show member pathways
8.4F2, THY1, SERPINE1, ITGB3
10
Show member pathways
thioredoxin pathway38
8.1PLAT, MTHFR, SERPINE1, F2
11
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
7.8F2, SERPINE1, SERPINC1, PLAT, F5
12
Show member pathways
7.8F5, PLAT, SERPINC1, SERPINE1, F2
13
Show member pathways
7.4F2, SERPINE1, SERPINC1, ITGB3, PLAT, F5

Compounds for genes affiliated with Central Retinal Artery Occlusion

About this section
Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1inogatran459.6F5, SERPINC1, F2
2hirugen459.6F2, F5, SERPINC1
3ecarin459.6F5, SERPINC1, F2
4danaparoid459.5F2, SERPINC1, F5
5ximelagatran45 1110.5F2, SERPINC1, F5
6heparinoids459.5F2, SERPINC1, F5
7desogestrel45 1110.4F5, F2, SERPINC1
8fibrinopeptide a459.4F2, PLAT, SERPINC1
9gestodene45 1110.3F5, SERPINC1, F2
10ppack459.2F2, SERPINC1, PLAT
11gabexate mesilate459.2PLAT, SERPINC1, F5
12tirofiban45 1110.1F2, SERPINC1, PLAT, ITGB3
13abciximab45 1110.1ITGB3, PLAT, SERPINC1, F2
14clopidogrel45 51 24 1112.1F2, SERPINC1, ITGB3, PLAT
15spectrozyme459.1F5, PLAT, SERPINC1, F2
16fondaparinux459.0F5, SERPINC1, F2, PLAT
17bivalirudin45 1110.0F2, SERPINC1, PLAT, F5
18argatroban45 1110.0SERPINC1, F5, PLAT, F2
19polyethylene glycol459.0F2, SERPINC1, F5, HMOX1
20protamine sulfate459.0SERPINC1, F2, PLAT, F5
21levonorgestrel45 61 29 1112.0PLAT, SERPINC1, F2, F5
22eaca459.0SERPINE1, PLAT, SERPINC1
23p-amino benzamidine458.9SERPINC1, PLAT, SERPINE1
24dermatan sulfate458.9F2, SERPINC1, PLAT, F5
25tibolone458.8SERPINE1, SERPINC1, F5
26ristocetin458.7F2, F5, PLAT, ITGB3, SERPINC1
27tranexamic acid45 119.7F2, SERPINE1, SERPINC1, PLAT
28epsilon aminocaproic acid458.6PLAT, SERPINC1, F2, SERPINE1
29batroxobin458.6F5, PLAT, F2, SERPINE1
30warfarin45 51 24 1111.5SERPINC1, F5, PLAT, MTHFR, F2
31ascorbic acid45 249.4SERPINC1, MTHFR, PLAT, F5, HMOX1
32pge1458.4F2, PLAT, F5, SERPINE1
33ancrod458.2PLAT, SERPINC1, SERPINE1, F2, F5
34prostacyclin458.2SERPINC1, SERPINE1, PLAT, F5, HMOX1
35desmopressin45 61 29 1111.2F5, PLAT, SERPINC1, SERPINE1, F2
36hirudin458.2SERPINC1, PLAT, SERPINE1, F5, F2
37simvastatin45 51 61 29 24 1113.2SERPINE1, F2, PLAT, F5, HMOX1
38protamine458.2F5, PLAT, SERPINC1, SERPINE1, F2
39kininogen458.2F5, PLAT, SERPINC1, SERPINE1, F2
40aprotinin45 119.2SERPINE1, SERPINC1, F2, F5, PLAT
41alanine458.0MTHFR, F5, HMOX1, F2, SERPINC1, ITGB3
42atorvastatin45 51 29 24 1112.0HMOX1, SERPINE1, F5, PLAT
43homocysteine45 248.7F2, SERPINE1, SERPINC1, F5, MTHFR, PLAT
44aspartate457.6ITGB3, PLAT, SERPINE1, F5, F2, MTHFR
45creatinine457.6F5, MTHFR, PLAT, SERPINC1, SERPINE1, F2
46heparin45 29 24 1110.6F5, F2, PLAT, MTHFR, SERPINC1, SERPINE1
47estrogen457.6ITGB3, F2, F5, SERPINC1, SERPINE1, MTHFR
48fibrinogen457.4ITGB3, F2, F5, PLAT, MTHFR, SERPINC1
49aspirin45 51 29 2410.1HMOX1, F5, PLAT, ITGB3, MTHFR, SERPINC1
50serine456.8SERPINE1, SERPINC1, MTHFR, ITGB3, F2, PLAT

GO Terms for genes affiliated with Central Retinal Artery Occlusion

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2F5, SERPINE1
2extracellular regionGO:0055767.7F2, SERPINE1, SERPINC1, PLAT, F5
3extracellular spaceGO:0056157.5HMOX1, F5, PLAT, SERPINC1, SERPINE1, F2
4plasma membraneGO:0058867.2F2, THY1, SERPINE1, SERPINC1, ITGB3, F5

Biological processes related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:0149099.7PLAT, ITGB3
2negative regulation of proteolysisGO:0458619.5PLAT, F2
3blood circulationGO:0080159.5F5, MTHFR
4positive regulation of release of sequestered calcium ion into cytosolGO:0512819.4THY1, F2
5negative regulation of fibrinolysisGO:0519189.4SERPINE1, F2
6positive regulation of blood coagulationGO:0301949.4SERPINE1, F2
7negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.3SERPINE1, HMOX1
8platelet degranulationGO:0025769.0SERPINE1, ITGB3, F5
9fibrinolysisGO:0427308.9F2, SERPINE1, PLAT
10platelet activationGO:0301688.7F5, ITGB3, SERPINE1, F2
11angiogenesisGO:0015258.5HMOX1, SERPINE1, THY1
12blood coagulationGO:0075967.7F5, PLAT, ITGB3, SERPINC1, SERPINE1, F2

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042528.7F5, PLAT, F2
2protein bindingGO:0055156.9THY1, SERPINE1, SERPINC1, ITGB3, PLAT, F5

Products for genes affiliated with Central Retinal Artery Occlusion

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Retinal Artery Occlusion

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet