MCID: CNT028
MIFTS: 37

Central Retinal Artery Occlusion malady

Categories: Eye diseases, Cardiovascular diseases

Aliases & Classifications for Central Retinal Artery Occlusion

Aliases & Descriptions for Central Retinal Artery Occlusion:

Name: Central Retinal Artery Occlusion 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13098
ICD10 33 H34.1
ICD9CM 35 362.31
MeSH 42 D015356
NCIt 47 C34456
SNOMED-CT 64 38742007
UMLS 69 C0007688

Summaries for Central Retinal Artery Occlusion

Disease Ontology : 12 A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.

MalaCards based summary : Central Retinal Artery Occlusion is related to retinitis and retinal artery occlusion. An important gene associated with Central Retinal Artery Occlusion is HMOX1 (Heme Oxygenase 1), and among its related pathways/superpathways are Fluid shear stress and atherosclerosis and Apelin signaling pathway. The drugs Aspirin and Dipyridamole have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina, and related phenotype is muscle.

Wikipedia : 71 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

Related Diseases for Central Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
id Related Disease Score Top Affiliating Genes
1 retinitis 11.1
2 retinal artery occlusion 11.1
3 neuropathy 10.3
4 cerebritis 10.2
5 lupus erythematosus 10.2
6 ischemic optic neuropathy 10.2
7 churg-strauss syndrome 10.2
8 retinal vein occlusion 10.1
9 systemic lupus erythematosus 10.1
10 lymphoma 10.1
11 sickle cell disease 10.1
12 central retinal vein occlusion 10.0
13 susac syndrome 10.0
14 choroiditis 10.0
15 herpes zoster 10.0
16 branch retinal artery occlusion 10.0
17 vasculitis 10.0
18 neovascular glaucoma 10.0
19 cellulitis 10.0
20 herpes zoster ophthalmicus 10.0
21 tuberculosis 10.0
22 carotid artery dissection 10.0
23 cervicitis 10.0
24 aneurysm 10.0
25 orbital cellulitis 10.0
26 polyarteritis nodosa 10.0
27 ischemia 10.0
28 immunodeficiency, common variable, 6 9.9 PLAT SERPINA10
29 patent foramen ovale 9.9
30 carotid artery disease 9.9
31 fibromuscular dysplasia 9.9
32 homocystinuria 9.9
33 nonarteritic anterior ischemic optic neuropathy 9.9
34 hyperhomocysteinemia 9.9
35 protein s deficiency 9.9
36 nasopharyngitis 9.9
37 pneumonia 9.9
38 juvenile nasopharyngeal angiofibroma 9.9
39 antiphospholipid syndrome 9.9
40 retinal ischemia 9.9
41 artery disease 9.9
42 myocardial infarction 9.9
43 amaurosis fugax 9.9
44 bone development disease 9.8 PLAT SERPINA10
45 ovarian hyperstimulation syndrome 9.7
46 chickenpox 9.7
47 catastrophic antiphospholipid syndrome 9.7
48 hodgkin lymphoma 9.7
49 crest syndrome 9.7
50 tetralogy of fallot 9.7

Comorbidity relations with Central Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to Central Retinal Artery Occlusion

Symptoms & Phenotypes for Central Retinal Artery Occlusion

MGI Mouse Phenotypes related to Central Retinal Artery Occlusion:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 ACTA2 HMOX1 PLAT TBCE

Drugs & Therapeutics for Central Retinal Artery Occlusion

Drugs for Central Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
2
Dipyridamole Approved Phase 4 58-32-2 3108
3
Ranibizumab Approved Phase 4 347396-82-1 459903
4 Fibrinolytic Agents Phase 4,Phase 3,Phase 1
5 Analgesics Phase 4,Phase 3
6 Analgesics, Non-Narcotic Phase 4,Phase 3
7 Anti-Inflammatory Agents Phase 4,Phase 3
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
9 Antipyretics Phase 4,Phase 3
10 Antirheumatic Agents Phase 4,Phase 3
11 Cyclooxygenase Inhibitors Phase 4,Phase 3
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
13 Phosphodiesterase Inhibitors Phase 4,Phase 2
14 Platelet Aggregation Inhibitors Phase 4,Phase 3
15 Vasodilator Agents Phase 4,Phase 2
16 insulin Phase 4
17 Insulin, Globin Zinc Phase 4
18 Angiogenesis Inhibitors Phase 4
19 Angiogenesis Modulating Agents Phase 4
20
Vorapaxar Approved Phase 3 618385-01-6
21
Ethanol Approved Phase 3 64-17-5 702
22
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
23
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
24 Neurotransmitter Agents Phase 3,Phase 2
25 Adrenergic Agents Phase 3
26 Adrenergic Antagonists Phase 3
27 Adrenergic beta-Antagonists Phase 3
28 Anticoagulants Phase 3
29 Anticonvulsants Phase 3
30 calcium heparin Phase 3
31 Carbonic Anhydrase Inhibitors Phase 3
32 diuretics Phase 3
33 Natriuretic Agents Phase 3
34
Papaverine Approved Phase 2 61-25-6, 58-74-2 4680
35
Adenosine Approved, Investigational Phase 2 58-61-7 60961
36
Regadenoson Approved Phase 2 313348-27-5 219024
37 Autonomic Agents Phase 2
38 Moxaverine Phase 2
39 Parasympatholytics Phase 2
40 Plasminogen Phase 1
41 Tissue Plasminogen Activator Phase 1
42
Dipivefrin Approved 52365-63-6 3105
43
Triamcinolone Approved, Vet_approved 124-94-7 31307
44
Bevacizumab Approved, Investigational 216974-75-3
45
Lidocaine Approved, Vet_approved 137-58-6 3676
46
Tetracaine Approved, Vet_approved 94-24-6 5411
47 Anesthetics
48 glucocorticoids
49 Hormone Antagonists
50 Hormones

Interventional clinical trials:

(show all 39)
id Name Status NCT ID Phase
1 ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial Completed NCT00161070 Phase 4
2 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4
3 Ranibizumab and the Risk of Arterial Thromboembolic Events Terminated NCT01319188 Phase 4
4 Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183) Completed NCT00617123 Phase 3
5 Effect of Aerobic EXercise on MiCroVAscular RarefacTION in Chinese Mild HyperteNsive Patients(EXCAVATION-CHN1) Recruiting NCT02817204 Phase 3
6 EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye Terminated NCT00637468 Phase 3
7 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
8 Hyperbaric Chamber for Central Retinal Vein Occlusion (CRVO) Patients Unknown status NCT02405741 Phase 2
9 Effects of Moxaverine and Placebo on Ocular Blood Flow Completed NCT00709423 Phase 2
10 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Recruiting NCT03090087 Phase 2
11 Intraocular Pressure During Prone Spinal Surgery Terminated NCT00176722 Phase 2
12 Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion Unknown status NCT01581411 Phase 1
13 Intravitreal Aflibercept Injection for Symptomatic Macular Edema From Retinal Artery Macroaneurysms Recruiting NCT02403128 Phase 1
14 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
15 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
16 OCT in Rare Chorioretinal Diseases Unknown status NCT02141308
17 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102
18 Sheathotomy vs. Intravitreal Triamcinolone for Branch Retinal Vein Occlusion Completed NCT00612261
19 Autonomic Nervous System Activity and Normal Tension Glaucoma Completed NCT01192061
20 Insulin Resistance and Atherosclerosis in Women With Lupus Completed NCT00544102
21 Retinal Arteriolar Abnormalities and CV Mortality Completed NCT00011167
22 Multi-Ethnic Study of Atherosclerosis (MESA) - Ancillary Eye Study Completed NCT00041444
23 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
24 Reconstruction of Pathological Changes of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Recruiting NCT02679716
25 Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome Recruiting NCT01481662
26 Ocular Discomfort Assessment After Intravitreal Injections Recruiting NCT02806830
27 Spectral-domain Optical Coherence Tomography of the Eye Recruiting NCT02614625
28 Investigation of Biomarkers in Susac Syndrome Recruiting NCT01273792
29 Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A) Recruiting NCT02811536
30 Retinal Thrombosis and Atherosclerosis Recruiting NCT02257333
31 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245
32 Retrospective Data Analysis of Patients Treated for Macular Edema Due to Central Retinal Vein Occlusion Active, not recruiting NCT02645747
33 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
34 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Not yet recruiting NCT02898480
35 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion Not yet recruiting NCT03061526
36 Evaluation of the Capacity of a Camera to Identify Signs of Arteriosclerosis in Retinal Arterioles Not yet recruiting NCT02849405
37 Ocular Effects of Carotid Endarterectomy Not yet recruiting NCT02448355
38 Topical Anesthesia and Intra-arterial Chemotherapy for Retinoblastoma Not yet recruiting NCT02955524
39 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

Anatomical Context for Central Retinal Artery Occlusion

MalaCards organs/tissues related to Central Retinal Artery Occlusion:

39
Eye, Brain, Retina, Lung, T Cells

Publications for Central Retinal Artery Occlusion

Articles related to Central Retinal Artery Occlusion:

(show top 50) (show all 458)
id Title Authors Year
1
CENTRAL RETINAL ARTERY OCCLUSION WITH DOUBLE CILIORETINAL ARTERY SPARING. ( 28085758 )
2017
2
Evaluation of Ophthalmic Artery Branch Retrograde Intervention in the Treatment of Central Retinal Artery Occlusion (CRAO). ( 28064304 )
2017
3
Management of acute central retinal artery occlusion: Intravenous thrombolysis is feasible and safe. ( 28067616 )
2017
4
PARACENTRAL ACUTE MIDDLE MACULOPATHY AND DEEP RETINAL CAPILLARY PLEXUS INFARCTION SECONDARY TO REPERFUSED CENTRAL RETINAL ARTERY OCCLUSION. ( 27668500 )
2017
5
Fusiform Left Carotid-Ophthalmic Artery Aneurysm Presenting with Central Retinal Artery Occlusion. ( 27865695 )
2017
6
Update on the Management of Central Retinal Artery Occlusion. ( 27886897 )
2017
7
Central retinal artery occlusion and cerebral infarction associated with Mycoplasma pneumonia infection in children. ( 27938350 )
2016
8
Manifestations of central retinal artery occlusion revealed by fundus fluorescein angiography are associated with the degree of visual loss. ( 27313672 )
2016
9
Central Retinal Artery Occlusion and Cerebral Infarction Following Stem Cell Injection for Baldness. ( 27941403 )
2016
10
STRANGULATION-INDUCED CENTRAL RETINAL ARTERY OCCLUSION: CASE REPORT AND REVIEW OF THE LITERATURE. ( 27337704 )
2016
11
Central Retinal Artery Occlusion With Subsequent Central Retinal Vein Occlusion in Biopsy-Proven Giant Cell Arteritis. ( 27261946 )
2016
12
CENTRAL RETINAL ARTERY OCCLUSION IN A YOUNG HIV-INFECTED PATIENT ON HIGHLY ACTIVE ANTIRETROVIRAL THERAPY. ( 27111556 )
2016
13
Central Retinal Artery Occlusion: A Literature Review and the Rationale for Hyperbaric Oxygen Therapy. ( 27039492 )
2016
14
Central Retinal Artery Occlusion in Takayasu's Arteritis as the First Presentation of the Disease. ( 27867673 )
2016
15
Central retinal artery occlusion as a presenting manifestation of polycythaemia vera. ( 27797860 )
2016
16
CORRELATION OF OPTICAL INTENSITY ON OPTICAL COHERENCE TOMOGRAPHY AND VISUAL OUTCOME IN CENTRAL RETINAL ARTERY OCCLUSION. ( 26966866 )
2016
17
Central retinal artery occlusion after phacoemulsification under peribulbar anaesthesia: Pathogenic hypothesis. ( 26652970 )
2016
18
Spectral-Domain Optical Coherence Tomography Angiography of Central Retinal Artery Occlusion. ( 27183551 )
2016
19
Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion. ( 27698763 )
2016
20
Central Retinal Artery Occlusion in a Teenager. ( 27012699 )
2016
21
Visual Improvement after Intra-Arterial Thrombolysis for Central Retinal Artery Occlusion Does Not Correlate with Time to Treatment. ( 27781041 )
2016
22
Comparison of hyperbaric oxygen versus iloprost treatment in an experimental rat central retinal artery occlusion model. ( 27480178 )
2016
23
Embolic Central Retinal Artery Occlusion Detected with Point-of-care Ultrasonography in the Emergency Department. ( 26879704 )
2016
24
Ambient Air Pollution and the Risk of Central Retinal Artery Occlusion. ( 27745901 )
2016
25
Multimodal imaging of central retinal artery occlusion with retained cilioretinal perfusion. ( 27530879 )
2016
26
Central Retinal Artery Occlusion Masquerading as Branch Retinal Artery Occlusion. ( 27729760 )
2016
27
Early Onset of Ocular Neovascularization After Hyperbaric Oxygen Therapy in a Patient With Central Retinal Artery Occlusion. ( 27613631 )
2016
28
Central retinal artery occlusion, an early sign of crizotinib resistance in an alk positive adenocarcinoma of lung: A rare case report. ( 27606884 )
2016
29
Incidence and Clinical Features of Neovascularization of the Iris following Acute Central Retinal Artery Occlusion. ( 27729755 )
2016
30
Necrotizing Fasciitis of the Periorbital Region Complicated by Combined Central Retinal Artery Occlusion, Central Retinal Vein Occlusion, and Posterior Ciliary Occlusion. ( 27556345 )
2016
31
Retinal and choroidal changes and visual outcome in central retinal artery occlusion: an optical coherence tomography study. ( 25579642 )
2015
32
Idiopathic central retinal artery occlusion in an eight-year-old girl. ( 26549139 )
2015
33
Should Patients With Acute Central Retinal Artery Occlusion Be Treated With Intra-arterial t-PA?: Comment. ( 26457689 )
2015
34
Missing the 'window' might shut the light forever: Central retinal artery occlusion following spine surgery. ( 26060596 )
2015
35
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY SHOWS DEEP CAPILLARY PLEXUS HYPOPERFUSION IN INCOMPLETE CENTRAL RETINAL ARTERY OCCLUSION. ( 26355822 )
2015
36
Acute Management of Central Retinal Artery Occlusion. ( 26322435 )
2015
37
Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion. ( 26089631 )
2015
38
Catastrophic antiphospholipid syndrome presenting as bilateral central retinal artery occlusions. ( 25722904 )
2015
39
Predictors of prognosis and treatment outcome in central retinal artery occlusion: local intra-arterial fibrinolysis vs. conservative treatment. ( 26349479 )
2015
40
Central retinal artery occlusion associated with persistent truncus arteriosus and single atrium: a case report. ( 26481874 )
2015
41
Central retinal artery occlusion with ophthalmoparesis in spontaneous carotid artery dissection. ( 25751487 )
2015
42
Unusual presentation of a multiple sclerosis case involving central retinal artery occlusion. ( 25892937 )
2015
43
Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography for central retinal artery occlusion. ( 25784298 )
2015
44
Intra-arterial thrombolysis of central retinal artery occlusion following percutaneous atrial septal defect closure. ( 26153142 )
2015
45
Bilateral Central Retinal Artery Occlusion in a Patient with Systemic Lupus Erythematosus. ( 25906934 )
2015
46
Should Patients With Acute Central Retinal Artery Occlusion Be Treated With Intra-arterial t-PA?: Response. ( 26457688 )
2015
47
Embolic central retinal artery occlusion after subcutaneous auricular steroid injection. ( 26631356 )
2015
48
Cardiovascular Risk Factors in Central Retinal Artery Occlusion: Results of a Prospective and Standardized Medical Examination. ( 26231133 )
2015
49
Intravenous Fibrinolytic Therapy in Central Retinal Artery Occlusion: A Patient-Level Meta-analysis. ( 26258861 )
2015
50
Iatrogenic Central Retinal Artery Occlusion Following Retrobulbar Anesthesia for Intraocular Surgery. ( 26240507 )
2015

Variations for Central Retinal Artery Occlusion

Expression for Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for Central Retinal Artery Occlusion

Pathways related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.1 HMOX1 PLAT
2 10.76 ACTA2 PLAT

GO Terms for Central Retinal Artery Occlusion

Cellular components related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 ACTA2 HMOX1 PLAT SERPINA10

Biological processes related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 8.62 ACTA2 HMOX1

Sources for Central Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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