MCID: CNT028
MIFTS: 49

Central Retinal Artery Occlusion malady

Eye diseases category

Summaries for Central Retinal Artery Occlusion

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63Wikipedia, 32MalaCards
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Wikipedia:63 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

MalaCards: Central Retinal Artery Occlusion is related to retinal vein occlusion and central retinal vein occlusion. An important gene associated with Central Retinal Artery Occlusion is SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10), and among its related pathways are Platelet activation, signaling and aggregation and Dissolution of Fibrin Clot. The compounds warfarin and aspartate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Central Retinal Artery Occlusion

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

central retinal artery occlusion 8 10 60


External Ids:

Disease Ontology8 DOID:13098
MeSH34 D015356
NCIt39 C34456
SNOMED-CT56 38742007
ICD9CM27 362.31
ICD1025 H34.1

Related Diseases for Central Retinal Artery Occlusion

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Central Retinal Artery Occlusion family:

Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vein occlusion30.9F5, MTHFR, SERPINC1
2central retinal vein occlusion30.9F5, PLAT, MTHFR
3lupus erythematosus30.8SERPINC1, F2, F5
4sickle cell disease30.8HMOX1
5branch retinal artery occlusion30.8PSD, F5
6vasculitis30.7F2
7migraine30.5MTHFR
8patent foramen ovale30.5F5
9retinal vascular occlusion30.5F5
10ischemia30.5PLAT, HMOX1
11homocystinuria30.5F5, MTHFR, SERPINC1
12protein s deficiency30.5F5, MTHFR, F2, SERPINE1, SERPINC1
13hyperhomocysteinemia30.5SERPINC1, SERPINE1, PLAT, F2, MTHFR, F5
14purpura30.3SERPINC1
15pneumonia30.3HMOX1
16sneddon syndrome30.3SERPINC1
17ovarian hyperstimulation syndrome30.3F5
18endophthalmitis30.3PLAT
19hemorrhagic disease30.3F5, F2, SERPINC1
20antiphospholipid syndrome30.2F5, MTHFR, F2, PLAT, SERPINC1
21myocardial infarction30.2ITGB3, F5, MTHFR, PLAT, SERPINE1, SERPINC1
22retinal artery occlusion11.5
23retinitis11.5
24retinal disease10.9
25neuropathy10.8
26carotid artery occlusion10.8
27ischemic neuropathy10.6
28transient retinal arterial occlusion10.6
29churg-strauss syndrome10.6
30ischemic optic neuropathy10.6
31glaucoma10.6
32systemic lupus erythematosus10.6
33wegener's granulomatosis10.6
34retinal drusen10.5
35cerebral artery occlusion10.5
36cerebritis10.5
37herpes zoster10.5
38retinal vasculitis10.5
39neovascular glaucoma10.4
40choroiditis10.4
41orbital cellulitis10.4
42cellulitis10.4
43carotid artery dissection10.4
44carotid artery disease10.4
45tuberculosis10.4
46partial arterial retinal occlusion10.4
47retinal ischemia10.4
48polyarteritis nodosa10.4
49cervicitis10.4
50ophthalmoplegia10.4

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to central retinal artery occlusion

Clinical Features for Central Retinal Artery Occlusion

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Drugs & Therapeutics for Central Retinal Artery Occlusion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Retinal Artery Occlusion

Drug clinical trials:

Search ClinicalTrials for Central Retinal Artery Occlusion

Search NIH Clinical Center for Central Retinal Artery Occlusion

Search CenterWatch for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

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Anatomical Context for Central Retinal Artery Occlusion

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32MalaCards
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MalaCards organs/tissues related to Central Retinal Artery Occlusion:

32
Eye, Retina, Brain, T cells

Animal Models for Central Retinal Artery Occlusion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Central Retinal Artery Occlusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.3ITGB3
2MP:00107719.5EMILIN1, F2, SLC17A8
3MP:00053899.2SERPINC1, HMOX1, MTHFR, ITGB3
4MP:00053859.0SERPINA10, HMOX1, F2, EMILIN1, ITGB3
5MP:00053708.5ITGB3, F5, HMOX1, SERPINE1, SERPINC1
6MP:00053767.3ITGB3, F5, MTHFR, F2, PLAT, HMOX1
7MP:00036317.3F5, MTHFR, F2, PLAT, THY1, SLC17A8
8MP:00107687.1ITGB3, F5, MTHFR, F2, PLAT, HMOX1

Publications for Central Retinal Artery Occlusion

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50PubMed
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Articles related to Central Retinal Artery Occlusion:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Ophthalmic artery aneurysm: potential culprit of central retinal artery occlusion. (24311936)
2013
2
A review of central retinal artery occlusion: clinical presentation and management. (23470793)
2013
3
Central retinal artery occlusion following peribulbar anesthesia for pterygium excision. (22605889)
2012
4
Branch retinal artery occlusion and central retinal vein occlusion associated with pegylated interferon plus ribavirin combination therapy for chronic hepatitis C. (22172047)
2012
5
Central retinal artery occlusion in a patient with ANCA-negative Churg-Strauss syndrome. (22927731)
2012
6
The incidence of central retinal artery occlusion in Olmsted County, Minnesota. (21794842)
2011
7
Churg-Strauss syndrome complicated by central retinal artery occlusion: case report and a review of the literature. (21308387)
2011
8
Hemi-central retinal artery occlusion in young adults. (21836357)
2011
9
Ocular neovascularization following central retinal artery occlusion: prevalence and timing of onset. (20544682)
2010
10
Successful treatment of longstanding vasospastic central retinal artery occlusion. (19173685)
2010
11
A patient with acute visual loss and transient neurologic symptoms. Diagnosis: an acute central retinal artery occlusion (CRAO) in the left eye with severe retinal ischemia. (20944529)
2010
12
Thrombolytic therapy in central retinal artery occlusion: cutting edge therapy, standard of care therapy, or impractical therapy? (19367164)
2009
13
Central retinal vein occlusion with cilioretinal infarction from branch flow exclusion and choroidal arterial steal. (19898176)
2009
14
Central retinal artery occlusion and ophthalmoplegia following spinal surgery in the prone position. (20954560)
2009
15
Vitreous surgery with direct central retinal artery massage for central retinal artery occlusion. (18483498)
2009
16
Sentinel central retinal artery occlusion: a forme fruste of idiopathic renal infarction. (19371552)
2009
17
Sequential bilateral central retinal artery occlusions in a female carrier of Fabry disease. (19788678)
2009
18
Combined central retinal artery and vein occlusion complicating orbital cellulitis. (18689145)
2008
19
An unusual cause of central retinal artery occlusion: acquired immunodeficiency syndrome. (17671949)
2007
20
Bilateral simultaneous central retinal artery occlusion following head injury. (17687521)
2007
21
Central retinal artery occlusion: association with patent foramen ovale. (15999129)
2006
22
Wegener's granulomatosis presenting with painless bulbar-conjunctival ulcer and central retinal artery occlusion. (16451259)
2006
23
Multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications. EAGLE Study report no. 1 : EAGLE Study report no. 1. (16372192)
2006
24
Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. (15654031)
2005
25
Activation of the mitochondrial apoptotic pathway in a rat model of central retinal artery occlusion. (15914634)
2005
26
Translumenal Nd:YAG laser embolysis for central retinal artery occlusion. (16141875)
2005
27
Protein Z levels and central retinal vein or artery occlusion. (16191090)
2005
28
Central retinal artery occlusion: visual outcome. (16138997)
2005
29
Central retinal artery occlusion in a patient with fibromuscular dysplasia. (15187675)
2004
30
Interventions for acute non-arteritic central retinal artery occlusion. (11869617)
2002
31
Intravenous recombinant tissue-type plasminogen activator thrombolysis in treatment of central retinal artery occlusion. (12215107)
2002
32
Central retinal artery occlusion associated with severe ovarian hyperstimulation syndrome. (11681515)
2001
33
Ocular massage in a case of central retinal artery occlusion the successful treatment of a hitherto undescribed type of embolism. (10799350)
2000
34
Color Doppler ultrasound investigation of the therapeutic effect of plasmapheresis on a lymphoplasmocytoid lymphoma (immunocytoma): a case of central retinal artery occlusion. (8695720)
1996
35
Central retinal artery occlusion in a child after general anesthesia. (1882928)
1991
36
Recurrent cerebral infarction and central retinal artery occlusion following mandibular zoster. (2036611)
1991
37
Central retinal artery occlusion in giant cell arteritis: treatment with nitroglycerin. (1922829)
1991
38
Central retinal artery occlusion in homozygous sickle cell (SS) disease. (3250792)
1988
39
Central retinal artery occlusion. (3574867)
1987
40
Central retinal artery occlusion with an irido-embolus following carotid endarterectomy. (2438321)
1987
41
Experimental retinal vascular occlusion. II. A clinico-pathologic correlative study of simultaneous occlusion of central retinal vein and artery. (3721721)
1986
42
Experimental retinal vascular occlusion. III. An ultrastructural study of simultaneous occlusion of central retinal vein and artery. (3721722)
1986
43
Central retinal artery occlusion following YAG synechialysis. (3977702)
1985
44
Herpes zoster and central retinal artery occlusion. (6830188)
1983
45
Central retinal artery occlusion after facial trauma. (424177)
1979
46
Electroretinographic changes and choroidal defects in a case of central retinal artery occlusion. (868944)
1977
47
Central retinal artery occlusion. (1121994)
1975
48
Central retinal artery occlusion after blow-out fracture repair. (4412362)
1974
49
Successful remission of central retinal artery occlusion following the use of isoxsuprine. (5652737)
1968
50
Idiopathic central retinal artery occlusion. Case report and presentation of a general guide to therapy. (13904598)
1962

Genetic Variations for Central Retinal Artery Occlusion

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Expression for genes affiliated with Central Retinal Artery Occlusion

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for genes affiliated with Central Retinal Artery Occlusion

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Sources:
53Reactome, 51QIAGEN, 4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Central Retinal Artery Occlusion

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.6SERPINC1
2aspartate4410.4F2
3heparin44 28 11 2413.2SERPINA10, MTHFR
4serine4410.1SERPINA10
5creatinine449.9F5, F2
6inogatran449.7F2, SERPINC1, F5
7ecarin449.7F5, SERPINC1, F2
8hirugen449.7SERPINC1, F2, F5
9danaparoid449.7F5, SERPINC1, F2
10ximelagatran44 1110.7F5, F2, SERPINC1
11heparinoids449.7SERPINC1, F5, F2
12fibrinopeptide a449.6SERPINC1, F2, PLAT
13desogestrel44 1110.6F5, SERPINC1, F2
14eaca449.6PLAT, SERPINC1, SERPINE1
15p-amino benzamidine449.6PLAT, SERPINC1, SERPINE1
16Drotrecogin alfa119.6F2, SERPINE1, F5
17ppack449.5SERPINC1, PLAT, F2
18gestodene44 1110.5SERPINC1, F5, F2
19tirofiban44 1110.4PLAT, SERPINC1, F2, ITGB3
20abciximab44 1110.4SERPINC1, ITGB3, PLAT, F2
21clopidogrel49 44 11 2412.4SERPINC1, PLAT, F2, ITGB3
22gabexate mesilate449.4SERPINC1, PLAT, F5
23tranexamic acid44 1110.3F2, SERPINE1, PLAT, SERPINC1
24tibolone449.3SERPINC1, SERPINE1, F5
25epsilon aminocaproic acid449.3PLAT, F2, SERPINC1, SERPINE1
26spectrozyme449.3PLAT, SERPINC1, F2, F5
27fondaparinux449.3F5, PLAT, SERPINC1, F2
28bivalirudin44 1110.3F2, SERPINC1, F5, PLAT
29argatroban44 1110.3SERPINC1, F5, PLAT, F2
30protamine sulfate449.2PLAT, F5, F2, SERPINC1
31batroxobin449.2F5, F2, PLAT, SERPINE1
32levonorgestrel44 59 28 1112.2PLAT, SERPINC1, F2, F5
33aprotinin44 1110.2F5, SERPINC1, SERPINE1, PLAT
34dermatan sulfate449.1SERPINC1, F5, F2, PLAT
35polyethylene glycol449.1F2, F5, SERPINC1, HMOX1
36ristocetin449.0F5, F2, ITGB3, PLAT, SERPINC1
37pge1448.9PLAT, SERPINE1, F2, F5
38ancrod448.9PLAT, F5, F2, SERPINC1, SERPINE1
39desmopressin44 59 28 1111.9PLAT, SERPINE1, SERPINC1, F5, F2
40hirudin448.9F5, SERPINC1, SERPINE1, PLAT, F2
41protamine448.9SERPINC1, F2, SERPINE1, F5, PLAT
42kininogen448.9F5, SERPINC1, SERPINE1, PLAT, F2
43simvastatin44 49 59 28 11 2413.8SERPINE1, HMOX1, PLAT, F2, F5
44prostacyclin448.8PLAT, HMOX1, SERPINE1, SERPINC1, F5
45ascorbic acid44 249.5SERPINC1, F5, MTHFR, PLAT, HMOX1
46atorvastatin44 49 28 11 2412.5F5, PLAT, HMOX1, SERPINE1
47homocysteine44 249.5F5, MTHFR, F2, PLAT, SERPINC1, SERPINE1
48alanine448.4ITGB3, SERPINC1, F5, F2, HMOX1, SERPINA10
49fibrinogen448.2SERPINE1, ITGB3, SERPINC1, PLAT, F2, MTHFR
50aspirin44 49 28 2410.9SERPINE1, HMOX1, F2, MTHFR, F5, ITGB3

GO Terms for genes affiliated with Central Retinal Artery Occlusion

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16Gene Ontology
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Cellular components related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1SERPINE1, PLAT, EMILIN1
2extracellular spaceGO:0056157.8SERPINC1, F5, F2, PLAT, HMOX1, SERPINA10
3extracellular regionGO:0055767.6F5, EMILIN1, F2, PLAT, SERPINE1, SERPINC1

Biological processes related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.9HMOX1, SERPINE1
2smooth muscle cell migrationGO:0149099.9PLAT, ITGB3
3negative regulation of fibrinolysisGO:0519189.8F2, SERPINE1
4negative regulation of endopeptidase activityGO:0109519.7SERPINA10, SERPINE1, SERPINC1
5positive regulation of blood coagulationGO:0301949.7SERPINE1, F2
6negative regulation of proteolysisGO:0458619.6PLAT, F2
7platelet degranulationGO:0025769.5SERPINE1, F5, ITGB3
8fibrinolysisGO:0427309.5F2, PLAT, SERPINE1
9platelet activationGO:0301689.2SERPINE1, F2, F5, ITGB3
10positive regulation of release of sequestered calcium ion into cytosolGO:0512819.2THY1, F2
11blood coagulationGO:0075968.2SERPINC1, SERPINE1, SERPINA10, PLAT, F2, F5

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.5SERPINC1, SERPINE1, SERPINA10

Products for genes affiliated with Central Retinal Artery Occlusion

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  • Antibodies
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Sources for Central Retinal Artery Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet