MCID: CNT028
MIFTS: 45

Central Retinal Artery Occlusion malady

Eye diseases category

Summaries for Central Retinal Artery Occlusion

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Wikipedia:63 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

MalaCards based summary: Central Retinal Artery Occlusion is related to branch retinal artery occlusion and sneddon syndrome. An important gene associated with Central Retinal Artery Occlusion is SLC17A8 (solute carrier family 17 (vesicular glutamate transporter), member 8), and among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Integrin alphaIIb beta3 signaling. The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Disease Ontology:9 A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.

Aliases & Classifications for Central Retinal Artery Occlusion

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Central Retinal Artery Occlusion, Aliases & Descriptions:

Name: Central Retinal Artery Occlusion 9 11 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:13098
NCIt38 C34456
MeSH33 D015356
SNOMED-CT55 38742007
ICD9CM27 362.31
ICD1025 H34.1

Related Diseases for Central Retinal Artery Occlusion

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Diseases in the Retinal Artery Occlusion family:

central retinal artery occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1branch retinal artery occlusion31.3F5
2sneddon syndrome31.1SERPINC1
3lupus erythematosus31.1F5, SERPINC1, F2
4purpura31.0SERPINC1
5retinal vein occlusion30.8SERPINC1, MTHFR, F5
6nonarteritic anterior ischemic optic neuropathy30.8MTHFR, F5
7endophthalmitis30.7PLAT
8homocystinuria30.6F5, MTHFR, SERPINC1
9central retinal vein occlusion30.3F5, PLAT, MTHFR
10atrial fibrillation30.3PLAT, F2
11protein s deficiency30.0F2, SERPINE1, SERPINC1, MTHFR, F5
12antiphospholipid syndrome29.8F2, SERPINC1, MTHFR, PLAT, F5
13hyperhomocysteinemia29.4PLAT, MTHFR, SERPINC1, SERPINE1, F2, F5
14myocardial infarction29.2F5, PLAT, ITGB3, MTHFR, SERPINC1, SERPINE1
15retinal artery occlusion11.6
16retinitis11.6
17neuropathy10.8
18ischemic optic neuropathy10.7
19systemic lupus erythematosus10.6
20churg-strauss syndrome10.6
21cerebritis10.6
22blindness10.6
23sickle cell disease10.6
24herpes zoster10.6
25choroiditis10.6
26vasculitis10.6
27susac syndrome10.6
28neovascular glaucoma10.5
29carotid artery dissection10.5
30polyarteritis nodosa10.5
31orbital cellulitis10.5
32cellulitis10.5
33ischemia10.5
34tuberculosis10.5
35herpes zoster ophthalmicus10.5
36factor xiii deficiency10.4F5
37migraine10.4
38retinal ischemia10.4
39patent foramen ovale10.4
40artery disease10.4
41carotid artery disease10.4
42cervicitis10.4
43ophthalmoplegia10.4
44amaurosis fugax10.4
45fibromuscular dysplasia10.4
46aneurysm10.4
47carotid artery thrombosis10.4SERPINE1
48hypersplenism10.4F2
49factor viii deficiency10.4F5
50hemophilia b10.4F2

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to central retinal artery occlusion

Symptoms for Central Retinal Artery Occlusion

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Drugs & Therapeutics for Central Retinal Artery Occlusion

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Drug clinical trials:

Search ClinicalTrials for Central Retinal Artery Occlusion

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

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Anatomical Context for Central Retinal Artery Occlusion

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MalaCards organs/tissues related to Central Retinal Artery Occlusion:

31
Eye, Brain, Retina, T cells

Animal Models for Central Retinal Artery Occlusion or affiliated genes

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Publications for Central Retinal Artery Occlusion

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Articles related to Central Retinal Artery Occlusion:

(show top 50)    (show all 399)
idTitleAuthorsYear
1
Retinal and choroidal changes and visual outcome in central retinal artery occlusion: an optical coherence tomography study. (25579642)
2015
2
Interest of local intra-arterial fibrinolysis in acute central retinal artery occlusion: Clinical experience in 16 patients. (25451669)
2014
3
Peripheral retinal ischemia after intravenous tissue plasminogen activator for central retinal artery occlusion. (25284117)
2014
4
Central retinal artery occlusion and brain infarctions after nasal filler injection. (25434051)
2014
5
Seronegative granulomatous polyangiitis with central retinal artery occlusion as the initial manifestation. (25372516)
2014
6
Nationwide incidence of clinically diagnosed central retinal artery occlusion in Korea, 2008 to 2011. (24913283)
2014
7
Systemic prostaglandin E1 to treat acute central retinal artery occlusion. (23580487)
2013
8
Unilateral central retinal artery occlusion as the sole presenting sign of Susac syndrome in a young man: case report. (24232952)
2013
9
Acute, bilateral, concurrent central retinal artery occlusion in sickle cell disease after use of tadalafil (Cialis). (24052082)
2013
10
Surgical embolectomy for central retinal artery occlusion. (23561615)
2013
11
Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion. (23619503)
2013
12
Carbogen in the management of a central retinal artery occlusion. (23256429)
2012
13
ANCA-associated vasculitis with central retinal artery occlusion developing during treatment with methimazole. (23154728)
2012
14
Comparison of optical coherence tomography findings in a patient with central retinal artery occlusion in one eye and end-stage glaucoma in the fellow eye. (22623869)
2012
15
Higher incidence of carotid stenosis in patients with central retinal artery occlusion. (20384592)
2011
16
Traumatic optic neuropathy and central retinal artery occlusion following blunt ocular trauma. (22043273)
2011
17
Lesions of the mitral valve as a cause of central retinal artery occlusion: presentation and discussion of two cases. (20070361)
2010
18
Teaching NeuroImages: central retinal artery occlusion with cilioretinal artery sparing in giant cell arteritis. (20679629)
2010
19
Translation of clinical studies to clinical practice: survey on the treatment of central retinal artery occlusion. (19540987)
2009
20
Thrombolytic therapy in central retinal artery occlusion: cutting edge therapy, standard of care therapy, or impractical therapy? (19367164)
2009
21
Molecular and histological changes following central retinal artery occlusion in a mouse model. (18639547)
2008
22
Central retinal artery occlusion following transcatheter balloon aortic valvuloplasty in an adolescent with aortic valvular stenosis. (18094913)
2008
23
Systemic diseases in non-inflammatory branch and central retinal artery occlusion--an overview of 416 patients. (18024271)
2007
24
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
25
An unusual cause of central retinal artery occlusion: acquired immunodeficiency syndrome. (17671949)
2007
26
Intra-arterial thrombolysis for central retinal artery occlusion in United States: Nationwide In-patient Survey 2001-2003. (17894624)
2007
27
Central retinal artery occlusion in an ANCA negative Churg-Strauss syndrome patient. (17522782)
2007
28
Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. (15654031)
2005
29
Neodymium:yttrium-aluminum-garnet laser arteriotomy with embolectomy for central retinal artery occlusion. (14700675)
2004
30
Recovery of vision after bilateral arteritic central retinal artery occlusion. (15068446)
2004
31
Selective intraarterial fibrinolysis of acute central retinal artery occlusion. (14616215)
2003
32
Chlamydia pneumoniae in central retinal artery occlusion. (12485289)
2002
33
Henoch-Schonlein purpura with bilateral central retinal artery occlusion. (11864898)
2002
34
Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: an experimental study in rhesus monkeys. (10926989)
2000
35
Central retinal artery occlusion in a patient homozygous for factor V Leiden. (10927002)
2000
36
Ocular massage in a case of central retinal artery occlusion the successful treatment of a hitherto undescribed type of embolism. (10799350)
2000
37
Characteristics of patients presenting with central retinal artery occlusion with and without giant cell arteritis. (11192446)
2000
38
Central retinal artery occlusion and bilateral choroidal infarcts in Wegener's granulomatosis. (10624439)
1999
39
A case of central retinal artery occlusion after carotid endoarterectomy. (9474333)
1997
40
Peripheral thrombolytic therapy for central retinal artery occlusion. CRAO Study Group. (7661736)
1995
41
Central retinal artery occlusion after varicella. (1642311)
1992
42
Central retinal artery occlusion in a child after general anesthesia. (1882928)
1991
43
Delayed filling of retinal and ciliary circulation after central retinal artery occlusion. (3060337)
1988
44
Emergent treatment of central retinal artery occlusion caused by embolism. (6878717)
1983
45
Treatment of acute central-retinal-artery occlusion. (82689)
1978
46
Central retinal artery occlusion (reversible in sickle trait with glaucoma. (952815)
1976
47
Central retinal artery occlusion. (1121994)
1975
48
Early diagnosis of an atrial myxoma with central retinal artery occlusion. (4429326)
1974
49
Central retinal artery occlusion associated with cryoglobulinemia. (13410214)
1957
50
Bilateral central retinal artery occlusion; occurrence in a patient with cortisone-treated systemic lupus erythematosus, sickle cell trait, and active pulmonary tuberculosis. (13257998)
1955

Variations for Central Retinal Artery Occlusion

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Expression for genes affiliated with Central Retinal Artery Occlusion

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Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for genes affiliated with Central Retinal Artery Occlusion

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Pathways related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGB3, F2
2
Show member pathways
9.7ITGB3, F2
39.3THY1, PLAT
49.3ITGB3, SERPINE1
5
Show member pathways
9.2F2, SERPINC1, F5
69.0PLAT, SERPINE1
7
Show member pathways
8.9F5, ITGB3, SERPINE1
88.8THY1, SERPINE1, ITGB3
9
Show member pathways
8.4F2, THY1, SERPINE1, ITGB3
10
Show member pathways
thioredoxin pathway36
8.1PLAT, MTHFR, SERPINE1, F2
11
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
7.8F2, SERPINE1, SERPINC1, PLAT, F5
12
Show member pathways
7.8F5, PLAT, SERPINC1, SERPINE1, F2
13
Show member pathways
7.4F2, SERPINE1, SERPINC1, ITGB3, PLAT, F5

Compounds for genes affiliated with Central Retinal Artery Occlusion

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Compounds related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1inogatran439.6F5, SERPINC1, F2
2hirugen439.6F2, F5, SERPINC1
3ecarin439.6F5, SERPINC1, F2
4danaparoid439.5F2, SERPINC1, F5
5ximelagatran43 1210.5F2, SERPINC1, F5
6heparinoids439.5F2, SERPINC1, F5
7desogestrel43 1210.4F5, F2, SERPINC1
8fibrinopeptide a439.4F2, PLAT, SERPINC1
9gestodene43 1210.3F5, SERPINC1, F2
10ppack439.2F2, SERPINC1, PLAT
11gabexate mesilate439.2PLAT, SERPINC1, F5
12tirofiban43 1210.1F2, SERPINC1, PLAT, ITGB3
13abciximab43 1210.1ITGB3, PLAT, SERPINC1, F2
14clopidogrel43 49 24 1212.1F2, SERPINC1, ITGB3, PLAT
15spectrozyme439.1F5, PLAT, SERPINC1, F2
16fondaparinux439.0F5, SERPINC1, F2, PLAT
17bivalirudin43 1210.0F2, SERPINC1, PLAT, F5
18argatroban43 1210.0SERPINC1, F5, PLAT, F2
19polyethylene glycol439.0F2, SERPINC1, F5, HMOX1
20protamine sulfate439.0SERPINC1, F2, PLAT, F5
21levonorgestrel43 59 28 1212.0PLAT, SERPINC1, F2, F5
22eaca439.0SERPINE1, PLAT, SERPINC1
23p-amino benzamidine438.9SERPINC1, PLAT, SERPINE1
24dermatan sulfate438.9F2, SERPINC1, PLAT, F5
25tibolone438.8SERPINE1, SERPINC1, F5
26ristocetin438.7F2, F5, PLAT, ITGB3, SERPINC1
27tranexamic acid43 129.7F2, SERPINE1, SERPINC1, PLAT
28epsilon aminocaproic acid438.6PLAT, SERPINC1, F2, SERPINE1
29batroxobin438.6F5, PLAT, F2, SERPINE1
30warfarin43 49 24 1211.5SERPINC1, F5, PLAT, MTHFR, F2
31ascorbic acid43 249.4SERPINC1, MTHFR, PLAT, F5, HMOX1
32pge1438.4F2, PLAT, F5, SERPINE1
33ancrod438.2PLAT, SERPINC1, SERPINE1, F2, F5
34prostacyclin438.2SERPINC1, SERPINE1, PLAT, F5, HMOX1
35desmopressin43 59 28 1211.2F5, PLAT, SERPINC1, SERPINE1, F2
36hirudin438.2SERPINC1, PLAT, SERPINE1, F5, F2
37simvastatin43 49 59 28 24 1213.2SERPINE1, F2, PLAT, F5, HMOX1
38protamine438.2F5, PLAT, SERPINC1, SERPINE1, F2
39kininogen438.2F5, PLAT, SERPINC1, SERPINE1, F2
40aprotinin43 129.2SERPINE1, SERPINC1, F2, F5, PLAT
41alanine438.0MTHFR, F5, HMOX1, F2, SERPINC1, ITGB3
42atorvastatin43 49 28 24 1212.0HMOX1, SERPINE1, F5, PLAT
43homocysteine43 248.7F2, SERPINE1, SERPINC1, F5, MTHFR, PLAT
44aspartate437.6ITGB3, PLAT, SERPINE1, F5, F2, MTHFR
45creatinine437.6F5, MTHFR, PLAT, SERPINC1, SERPINE1, F2
46heparin43 28 24 1210.6F5, F2, PLAT, MTHFR, SERPINC1, SERPINE1
47estrogen437.6ITGB3, F2, F5, SERPINC1, SERPINE1, MTHFR
48fibrinogen437.4ITGB3, F2, F5, PLAT, MTHFR, SERPINC1
49aspirin43 49 28 2410.1HMOX1, F5, PLAT, ITGB3, MTHFR, SERPINC1
50serine436.8SERPINE1, SERPINC1, MTHFR, ITGB3, F2, PLAT

GO Terms for genes affiliated with Central Retinal Artery Occlusion

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Cellular components related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.2F5, SERPINE1
2extracellular regionGO:00055767.7F2, SERPINE1, SERPINC1, PLAT, F5
3extracellular spaceGO:00056157.5HMOX1, F5, PLAT, SERPINC1, SERPINE1, F2
4plasma membraneGO:00058867.2F2, THY1, SERPINE1, SERPINC1, ITGB3, F5

Biological processes related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:00149099.7PLAT, ITGB3
2negative regulation of proteolysisGO:00458619.5PLAT, F2
3blood circulationGO:00080159.5F5, MTHFR
4positive regulation of release of sequestered calcium ion into cytosolGO:00512819.4THY1, F2
5negative regulation of fibrinolysisGO:00519189.4SERPINE1, F2
6positive regulation of blood coagulationGO:00301949.4SERPINE1, F2
7negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:019020429.3SERPINE1, HMOX1
8platelet degranulationGO:00025769.0SERPINE1, ITGB3, F5
9fibrinolysisGO:00427308.9F2, SERPINE1, PLAT
10platelet activationGO:00301688.7F5, ITGB3, SERPINE1, F2
11angiogenesisGO:00015258.5HMOX1, SERPINE1, THY1
12blood coagulationGO:00075967.7F5, PLAT, ITGB3, SERPINC1, SERPINE1, F2

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042528.7F5, PLAT, F2
2protein bindingGO:00055156.9THY1, SERPINE1, SERPINC1, ITGB3, PLAT, F5

Products for genes affiliated with Central Retinal Artery Occlusion

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Sources for Central Retinal Artery Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet