MCID: CNT028
MIFTS: 53

Central Retinal Artery Occlusion malady

Eye diseases, Cardiovascular diseases categories
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Summaries for Central Retinal Artery Occlusion

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Wikipedia:65 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

MalaCards based summary: Central Retinal Artery Occlusion is related to branch retinal artery occlusion and sneddon syndrome. An important gene associated with Central Retinal Artery Occlusion is SLC17A8 (solute carrier family 17 (vesicular glutamate transporter), member 8), and among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Integrin alphaIIb beta3 signaling. The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Disease Ontology:8 A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.

Aliases & Classifications for Central Retinal Artery Occlusion

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Central Retinal Artery Occlusion, Aliases & Descriptions:

Name: Central Retinal Artery Occlusion 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:13098
MeSH34 D015356
ICD9CM27 362.31
SNOMED-CT57 38742007
NCIt39 C34456
ICD1025 H34.1

Related Diseases for Central Retinal Artery Occlusion

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Diseases in the Central Retinal Artery Occlusion family:

Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1branch retinal artery occlusion31.3F5
2sneddon syndrome31.1SERPINC1
3lupus erythematosus31.0F5, SERPINC1, F2
4purpura31.0SERPINC1
5retinal vein occlusion30.8SERPINC1, MTHFR, F5
6endophthalmitis30.7PLAT
7homocystinuria30.6F5, MTHFR, SERPINC1
8central retinal vein occlusion30.4F5, PLAT, MTHFR
9protein s deficiency30.0F2, SERPINE1, SERPINC1, MTHFR, F5
10antiphospholipid syndrome29.6F2, SERPINC1, MTHFR, PLAT, F5
11hyperhomocysteinemia29.5PLAT, MTHFR, SERPINC1, SERPINE1, F2, F5
12myocardial infarction29.3F5, PLAT, ITGB3, MTHFR, SERPINC1, SERPINE1
13thromboembolism29.2F2, SERPINE1, SERPINC1, MTHFR, PLAT, F5
14retinal artery occlusion11.5
15retinitis11.5
16neuropathy10.8
17ischemic optic neuropathy10.7
18churg-strauss syndrome10.7
19cerebritis10.6
20anterior ischemic optic neuropathy10.6
21blindness10.6
22systemic lupus erythematosus10.6
23wegener's granulomatosis10.6
24sickle cell disease10.6
25vasculitis10.6
26susac syndrome10.6
27neovascular glaucoma10.5
28polyarteritis nodosa10.5
29herpes zoster10.5
30choroiditis10.5
31orbital cellulitis10.5
32cellulitis10.5
33ischemia10.5
34tuberculosis10.5
35herpes zoster ophthalmicus10.5
36factor xii deficiency10.4F5
37retinal ischemia10.4
38patent foramen ovale10.4
39carotid artery dissection10.4
40artery disease10.4
41carotid artery disease10.4
42migraine10.4
43ophthalmoplegia10.4
44amaurosis fugax10.4
45fibromuscular dysplasia10.4
46aneurysm10.4
47carotid artery thrombosis10.4SERPINE1
48hypersplenism10.4F2
49factor viii deficiency10.4F5
50hemophilia b10.4F2

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to central retinal artery occlusion

Symptoms for Central Retinal Artery Occlusion

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Drugs & Therapeutics for Central Retinal Artery Occlusion

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Drug clinical trials:

Search ClinicalTrials for Central Retinal Artery Occlusion

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

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Anatomical Context for Central Retinal Artery Occlusion

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MalaCards organs/tissues related to Central Retinal Artery Occlusion:

32
Eye, Brain, Retina, T cells

Animal Models for Central Retinal Artery Occlusion or affiliated genes

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Publications for Central Retinal Artery Occlusion

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Articles related to Central Retinal Artery Occlusion:

(show top 50)    (show all 382)
idTitleAuthorsYear
1
Peripheral retinal ischemia after intravenous tissue plasminogen activator for central retinal artery occlusion. (25284117)
2014
2
Seronegative granulomatous polyangiitis with central retinal artery occlusion as the initial manifestation. (25372516)
2014
3
Nationwide incidence of clinically diagnosed central retinal artery occlusion in Korea, 2008 to 2011. (24913283)
2014
4
Systemic prostaglandin E1 to treat acute central retinal artery occlusion. (23580487)
2013
5
Unilateral central retinal artery occlusion as the sole presenting sign of Susac syndrome in a young man: case report. (24232952)
2013
6
Acute, bilateral, concurrent central retinal artery occlusion in sickle cell disease after use of tadalafil (Cialis). (24052082)
2013
7
Surgical embolectomy for central retinal artery occlusion. (23561615)
2013
8
Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion. (23619503)
2013
9
Carbogen in the management of a central retinal artery occlusion. (23256429)
2012
10
ANCA-associated vasculitis with central retinal artery occlusion developing during treatment with methimazole. (23154728)
2012
11
Comparison of optical coherence tomography findings in a patient with central retinal artery occlusion in one eye and end-stage glaucoma in the fellow eye. (22623869)
2012
12
Higher incidence of carotid stenosis in patients with central retinal artery occlusion. (20384592)
2011
13
Traumatic optic neuropathy and central retinal artery occlusion following blunt ocular trauma. (22043273)
2011
14
Central retinal artery occlusion resembling Purtscher-like retinopathy. (21847341)
2011
15
Lesions of the mitral valve as a cause of central retinal artery occlusion: presentation and discussion of two cases. (20070361)
2010
16
Teaching NeuroImages: central retinal artery occlusion with cilioretinal artery sparing in giant cell arteritis. (20679629)
2010
17
Sequential central retinal artery occlusion and retinal vein stasis as a result of ocular ischemic syndrome. (20408094)
2010
18
Translation of clinical studies to clinical practice: survey on the treatment of central retinal artery occlusion. (19540987)
2009
19
Thrombolytic therapy in central retinal artery occlusion: cutting edge therapy, standard of care therapy, or impractical therapy? (19367164)
2009
20
Molecular and histological changes following central retinal artery occlusion in a mouse model. (18639547)
2008
21
Central retinal artery occlusion following transcatheter balloon aortic valvuloplasty in an adolescent with aortic valvular stenosis. (18094913)
2008
22
Systemic diseases in non-inflammatory branch and central retinal artery occlusion--an overview of 416 patients. (18024271)
2007
23
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
24
An unusual cause of central retinal artery occlusion: acquired immunodeficiency syndrome. (17671949)
2007
25
Intra-arterial thrombolysis for central retinal artery occlusion in United States: Nationwide In-patient Survey 2001-2003. (17894624)
2007
26
Central retinal artery occlusion in an ANCA negative Churg-Strauss syndrome patient. (17522782)
2007
27
Ocular ischemic syndrome presenting as central retinal artery occlusion in scleroderma. (16395147)
2006
28
Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. (15654031)
2005
29
Neodymium:yttrium-aluminum-garnet laser arteriotomy with embolectomy for central retinal artery occlusion. (14700675)
2004
30
Recovery of vision after bilateral arteritic central retinal artery occlusion. (15068446)
2004
31
Selective intraarterial fibrinolysis of acute central retinal artery occlusion. (14616215)
2003
32
Chlamydia pneumoniae in central retinal artery occlusion. (12485289)
2002
33
Henoch-Schonlein purpura with bilateral central retinal artery occlusion. (11864898)
2002
34
Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: an experimental study in rhesus monkeys. (10926989)
2000
35
Central retinal artery occlusion in a patient homozygous for factor V Leiden. (10927002)
2000
36
Ocular massage in a case of central retinal artery occlusion the successful treatment of a hitherto undescribed type of embolism. (10799350)
2000
37
Characteristics of patients presenting with central retinal artery occlusion with and without giant cell arteritis. (11192446)
2000
38
Central retinal artery occlusion and bilateral choroidal infarcts in Wegener's granulomatosis. (10624439)
1999
39
A case of central retinal artery occlusion after carotid endoarterectomy. (9474333)
1997
40
Peripheral thrombolytic therapy for central retinal artery occlusion. CRAO Study Group. (7661736)
1995
41
Central retinal artery occlusion after varicella. (1642311)
1992
42
Central retinal artery occlusion in a child after general anesthesia. (1882928)
1991
43
Delayed filling of retinal and ciliary circulation after central retinal artery occlusion. (3060337)
1988
44
Emergent treatment of central retinal artery occlusion caused by embolism. (6878717)
1983
45
Treatment of acute central-retinal-artery occlusion. (82689)
1978
46
Central retinal artery occlusion (reversible in sickle trait with glaucoma. (952815)
1976
47
Central retinal artery occlusion. (1121994)
1975
48
Early diagnosis of an atrial myxoma with central retinal artery occlusion. (4429326)
1974
49
Central retinal artery occlusion associated with cryoglobulinemia. (13410214)
1957
50
Bilateral central retinal artery occlusion; occurrence in a patient with cortisone-treated systemic lupus erythematosus, sickle cell trait, and active pulmonary tuberculosis. (13257998)
1955

Variations for Central Retinal Artery Occlusion

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Expression for genes affiliated with Central Retinal Artery Occlusion

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Expression patterns in normal tissues for genes affiliated with Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for genes affiliated with Central Retinal Artery Occlusion

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Pathways related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGB3, F2
2
Show member pathways
9.7ITGB3, F2
39.3THY1, PLAT
49.3ITGB3, SERPINE1
5
Show member pathways
9.2F2, SERPINC1, F5
69.0PLAT, SERPINE1
7
Show member pathways
8.9F5, ITGB3, SERPINE1
88.8THY1, SERPINE1, ITGB3
9
Show member pathways
8.4F2, THY1, SERPINE1, ITGB3
10
Show member pathways
thioredoxin pathway37
8.1PLAT, MTHFR, SERPINE1, F2
11
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
7.8F2, SERPINE1, SERPINC1, PLAT, F5
12
Show member pathways
7.8F5, PLAT, SERPINC1, SERPINE1, F2
13
Show member pathways
7.4F2, SERPINE1, SERPINC1, ITGB3, PLAT, F5

Compounds for genes affiliated with Central Retinal Artery Occlusion

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Compounds related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1inogatran449.6F5, SERPINC1, F2
2hirugen449.6F2, F5, SERPINC1
3ecarin449.6F5, SERPINC1, F2
4danaparoid449.5F2, SERPINC1, F5
5ximelagatran44 1110.5F2, SERPINC1, F5
6heparinoids449.5F2, SERPINC1, F5
7desogestrel44 1110.4F5, F2, SERPINC1
8fibrinopeptide a449.4F2, PLAT, SERPINC1
9gestodene44 1110.3F5, SERPINC1, F2
10ppack449.2F2, SERPINC1, PLAT
11gabexate mesilate449.2PLAT, SERPINC1, F5
12tirofiban44 1110.1F2, SERPINC1, PLAT, ITGB3
13abciximab44 1110.1ITGB3, PLAT, SERPINC1, F2
14clopidogrel44 50 24 1112.1F2, SERPINC1, ITGB3, PLAT
15spectrozyme449.1F5, PLAT, SERPINC1, F2
16fondaparinux449.0F5, SERPINC1, F2, PLAT
17bivalirudin44 1110.0F2, SERPINC1, PLAT, F5
18argatroban44 1110.0SERPINC1, F5, PLAT, F2
19polyethylene glycol449.0F2, SERPINC1, F5, HMOX1
20protamine sulfate449.0SERPINC1, F2, PLAT, F5
21levonorgestrel44 61 28 1112.0PLAT, SERPINC1, F2, F5
22eaca449.0SERPINE1, PLAT, SERPINC1
23p-amino benzamidine448.9SERPINC1, PLAT, SERPINE1
24dermatan sulfate448.9F2, SERPINC1, PLAT, F5
25tibolone448.8SERPINE1, SERPINC1, F5
26ristocetin448.7F2, F5, PLAT, ITGB3, SERPINC1
27tranexamic acid44 119.7F2, SERPINE1, SERPINC1, PLAT
28epsilon aminocaproic acid448.6PLAT, SERPINC1, F2, SERPINE1
29batroxobin448.6F5, PLAT, F2, SERPINE1
30warfarin44 50 24 1111.5SERPINC1, F5, PLAT, MTHFR, F2
31ascorbic acid44 249.4SERPINC1, MTHFR, PLAT, F5, HMOX1
32pge1448.4F2, PLAT, F5, SERPINE1
33ancrod448.2PLAT, SERPINC1, SERPINE1, F2, F5
34prostacyclin448.2SERPINC1, SERPINE1, PLAT, F5, HMOX1
35desmopressin44 61 28 1111.2F5, PLAT, SERPINC1, SERPINE1, F2
36hirudin448.2SERPINC1, PLAT, SERPINE1, F5, F2
37simvastatin44 50 61 28 24 1113.2SERPINE1, F2, PLAT, F5, HMOX1
38protamine448.2F5, PLAT, SERPINC1, SERPINE1, F2
39kininogen448.2F5, PLAT, SERPINC1, SERPINE1, F2
40aprotinin44 119.2SERPINE1, SERPINC1, F2, F5, PLAT
41alanine448.0MTHFR, F5, HMOX1, F2, SERPINC1, ITGB3
42atorvastatin44 50 28 24 1112.0HMOX1, SERPINE1, F5, PLAT
43homocysteine44 248.7F2, SERPINE1, SERPINC1, F5, MTHFR, PLAT
44aspartate447.6ITGB3, PLAT, SERPINE1, F5, F2, MTHFR
45creatinine447.6F5, MTHFR, PLAT, SERPINC1, SERPINE1, F2
46heparin44 28 24 1110.6F5, F2, PLAT, MTHFR, SERPINC1, SERPINE1
47estrogen447.6ITGB3, F2, F5, SERPINC1, SERPINE1, MTHFR
48fibrinogen447.4ITGB3, F2, F5, PLAT, MTHFR, SERPINC1
49aspirin44 50 28 2410.1HMOX1, F5, PLAT, ITGB3, MTHFR, SERPINC1
50serine446.8SERPINE1, SERPINC1, MTHFR, ITGB3, F2, PLAT

GO Terms for genes affiliated with Central Retinal Artery Occlusion

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Cellular components related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2F5, SERPINE1
2extracellular regionGO:0055767.7F2, SERPINE1, SERPINC1, PLAT, F5
3extracellular spaceGO:0056157.5HMOX1, F5, PLAT, SERPINC1, SERPINE1, F2
4plasma membraneGO:0058867.2F2, THY1, SERPINE1, SERPINC1, ITGB3, F5

Biological processes related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:0149099.7PLAT, ITGB3
2negative regulation of proteolysisGO:0458619.5PLAT, F2
3blood circulationGO:0080159.5F5, MTHFR
4positive regulation of release of sequestered calcium ion into cytosolGO:0512819.4THY1, F2
5negative regulation of fibrinolysisGO:0519189.4SERPINE1, F2
6positive regulation of blood coagulationGO:0301949.4SERPINE1, F2
7negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.3SERPINE1, HMOX1
8platelet degranulationGO:0025769.0SERPINE1, ITGB3, F5
9fibrinolysisGO:0427308.9F2, SERPINE1, PLAT
10platelet activationGO:0301688.7F5, ITGB3, SERPINE1, F2
11angiogenesisGO:0015258.5HMOX1, SERPINE1, THY1
12blood coagulationGO:0075967.7F5, PLAT, ITGB3, SERPINC1, SERPINE1, F2

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042528.7F5, PLAT, F2
2protein bindingGO:0055156.9THY1, SERPINE1, SERPINC1, ITGB3, PLAT, F5

Products for genes affiliated with Central Retinal Artery Occlusion

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Sources for Central Retinal Artery Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet