MCID: CNT028
MIFTS: 40

Central Retinal Artery Occlusion

Categories: Eye diseases, Cardiovascular diseases

Aliases & Classifications for Central Retinal Artery Occlusion

MalaCards integrated aliases for Central Retinal Artery Occlusion:

Name: Central Retinal Artery Occlusion 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13098
ICD10 32 H34.1
ICD9CM 34 362.31
MeSH 41 D015356
NCIt 46 C34456
SNOMED-CT 64 38742007
UMLS 69 C0007688

Summaries for Central Retinal Artery Occlusion

Disease Ontology : 12 A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.

MalaCards based summary : Central Retinal Artery Occlusion is related to carotid artery dissection and arteries, anomalies of. An important gene associated with Central Retinal Artery Occlusion is HMOX1 (Heme Oxygenase 1), and among its related pathways/superpathways are Cell adhesion_ECM remodeling and Cell adhesion_Plasmin signaling. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina.

Wikipedia : 72 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

Related Diseases for Central Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 carotid artery dissection 30.2 PLAT PLG
2 arteries, anomalies of 29.8 PLAT PLG
3 branch retinal artery occlusion 29.8 FANCG TBCE
4 thrombosis 29.0 PLAT SERPINA10
5 retinitis 11.1
6 retinal artery occlusion 11.1
7 neuropathy 10.4
8 cerebritis 10.3
9 ischemic optic neuropathy 10.2
10 churg-strauss syndrome 10.2
11 lupus erythematosus 10.2
12 ligneous conjunctivitis 10.2 PLAT PLG
13 inferior myocardial infarction 10.2 PLAT PLG
14 intracranial embolism 10.2 PLAT PLG
15 systemic lupus erythematosus 10.2
16 nonarteritic anterior ischemic optic neuropathy 10.2
17 retinal vein occlusion 10.2
18 occlusion precerebral artery 10.2 PLAT PLG
19 basilar artery occlusion 10.2 PLAT PLG
20 acute cor pulmonale 10.2 PLAT PLG
21 acute pulmonary heart disease 10.2 PLAT PLG
22 hydrops, lactic acidosis, and sideroblastic anemia 10.1
23 lymphoma 10.1
24 sickle cell disease 10.1
25 aneurysm 10.1
26 intermediate coronary syndrome 10.1 PLAT PLG
27 stroke, ischemic 10.1
28 choroiditis 10.1
29 neovascular glaucoma 10.1
30 central retinal vein occlusion 10.1
31 ischemia 10.1
32 herpes zoster 10.1
33 vasculitis 10.1
34 susac syndrome 10.1
35 vein disease 10.1 PLAT PLG
36 hepatic veno-occlusive disease 10.1 PLAT PLG
37 dirofilariasis 10.1 PLAT PLG
38 mycobacterium tuberculosis 1 10.0
39 polyarteritis nodosa, childhood-onset 10.0
40 retinal ischemia 10.0
41 orbital cellulitis 10.0
42 cervicitis 10.0
43 cellulitis 10.0
44 polyarteritis nodosa 10.0
45 herpes zoster ophthalmicus 10.0
46 thrombophilia due to activated protein c resistance 10.0 PLAT PLG
47 disseminated intravascular coagulation 10.0 PLAT PLG
48 fibromuscular dysplasia 9.9
49 migraine with or without aura 1 9.9
50 myocardial infarction 9.9

Comorbidity relations with Central Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to Central Retinal Artery Occlusion

Symptoms & Phenotypes for Central Retinal Artery Occlusion

Drugs & Therapeutics for Central Retinal Artery Occlusion

Drugs for Central Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4
3 Angiogenesis Modulating Agents Phase 4
4 insulin Phase 4
5 Insulin, Globin Zinc Phase 4
6
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
7
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
8
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
9
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
10 Analgesics Phase 3
11 Analgesics, Non-Narcotic Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Antipyretics Phase 3
15 Antirheumatic Agents Phase 3
16 Cyclooxygenase Inhibitors Phase 3
17 Fibrinolytic Agents Phase 3
18 Peripheral Nervous System Agents Phase 3
19 Pharmaceutical Solutions Phase 3
20 Plasminogen Phase 3
21 Platelet Aggregation Inhibitors Phase 3
22 Tissue Plasminogen Activator Phase 3
23 Adrenergic Agents Phase 3
24 Adrenergic Antagonists Phase 3
25 Adrenergic beta-Antagonists Phase 3
26 Anticoagulants Phase 3
27 Anticonvulsants Phase 3
28 calcium heparin Phase 3
29 Carbonic Anhydrase Inhibitors Phase 3
30 diuretics Phase 3
31 Natriuretic Agents Phase 3
32 Neurotransmitter Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4 ranibizumab
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Not yet recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
6 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
7 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817
8 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245
9 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

Anatomical Context for Central Retinal Artery Occlusion

MalaCards organs/tissues related to Central Retinal Artery Occlusion:

38
Eye, Brain, Retina, T Cells, Lung

Publications for Central Retinal Artery Occlusion

Articles related to Central Retinal Artery Occlusion:

(show top 50) (show all 490)
# Title Authors Year
1
Current treatment of central retinal artery occlusion: a national survey. ( 29236169 )
2018
2
Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion. ( 29358594 )
2018
3
Ophthalmic artery MRI in an arteritis-related central retinal artery occlusion. ( 29358510 )
2018
4
Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion. ( 29378380 )
2018
5
Thrombus in Lamina Cribrosa Seen Using Swept-Source Optical Coherence Tomography in Eye With Central Retinal Artery Occlusion. ( 29360684 )
2018
6
Cystoid Macular Edema with Idiopathic Acute Central Retinal Artery Occlusion in a Healthy Child. ( 28791072 )
2017
7
Is Intravenous Thrombolysis Safe and Effective in Central Retinal Artery Occlusion? A Critically Appraised Topic. ( 28644261 )
2017
8
Evaluation of Ophthalmic Artery Branch Retrograde Intervention in the Treatment of Central Retinal Artery Occlusion (CRAO). ( 28064304 )
2017
9
Central Retinal Artery Occlusion by Left Atrial Myxoma. ( 28243029 )
2017
10
Optical Coherence Tomography Angiography of a Central Retinal Artery Occlusion Before and After Anterior Chamber Paracentesis. ( 28433123 )
2017
11
CENTRAL RETINAL ARTERY OCCLUSION WITH DOUBLE CILIORETINAL ARTERY SPARING. ( 28085758 )
2017
12
Central retinal artery occlusion in a 30-year-old woman taking tranexamic acid. ( 28705840 )
2017
13
Triamcinolone emboli leading to central retinal artery occlusion: a multimodal imaging study. ( 28228436 )
2017
14
Bilateral Central Retinal Artery Occlusion Associated with Bilateral Lymphoproliferative Infiltrative Optic Neuropathy. ( 29071274 )
2017
15
Central retinal artery occlusion without underlying chronic ocular ischemic syndrome may lead to neovascular glaucoma. ( 29055729 )
2017
16
The efficacy of hyperbaric oxygen therapy in the treatment of central retinal artery occlusion. ( 28500127 )
2017
17
Central retinal artery occlusion after percutaneous nephrolithotomy lithotripsy in the prone position. ( 28097535 )
2017
18
Transient central retinal artery occlusion after sub-tenon's anaesthesia: Is it a safe technique? ( 28755793 )
2017
19
Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. ( 28096655 )
2017
20
The Penumbra Obscura Stimulates Iris Neovascularisation after Isolated Central Retinal Artery Occlusion. ( 28367049 )
2017
21
Fusiform Left Carotid-Ophthalmic Artery Aneurysm Presenting with Central Retinal Artery Occlusion. ( 27865695 )
2017
22
Multimodal Images of Acute Central Retinal Artery Occlusion. ( 29348953 )
2017
23
Update on the Management of Central Retinal Artery Occlusion. ( 27886897 )
2017
24
Traumatic optic neuropathy and central retinal artery occlusion following blunt trauma to the eyebrow. ( 29264089 )
2017
25
PARACENTRAL ACUTE MIDDLE MACULOPATHY AND DEEP RETINAL CAPILLARY PLEXUS INFARCTION SECONDARY TO REPERFUSED CENTRAL RETINAL ARTERY OCCLUSION. ( 27668500 )
2017
26
Disappearance of Myelinated Retinal Nerve Fibers after Central Retinal Artery Occlusion Reveals Nettleship Collaterals. ( 28823346 )
2017
27
Hyperbaric, Central Retinal Artery Occlusion ( 28613728 )
2017
28
Systemic intravenous abciximab: a novel treatment for acute central retinal artery occlusion? ( 28470954 )
2017
29
Carotid cavernous fistula with central retinal artery occlusion and Terson syndrome after mid-facial trauma. ( 28580223 )
2017
30
Management of acute central retinal artery occlusion: Intravenous thrombolysis is feasible and safe. ( 28067616 )
2017
31
Visual loss due to optic nerve infarction and central retinal artery occlusion after spine surgery in the prone position: A case report. ( 28767569 )
2017
32
Central Retinal Artery Occlusion: Acute Management and Treatment. ( 29051845 )
2017
33
Transient central retinal artery occlusion following viperine snake bite. ( 29217042 )
2017
34
Central Retinal Artery Occlusion ( 29262124 )
2017
35
Iatrogenic central retinal artery occlusion after carotid body tumor embolization and excision. ( 28401029 )
2017
36
Simultaneous Traumatic Central Retinal Artery Occlusion and Optic Neuropathy. ( 29055368 )
2017
37
Early Onset of Ocular Neovascularization After Hyperbaric Oxygen Therapy in a Patient With Central Retinal Artery Occlusion. ( 27613631 )
2016
38
Central retinal artery occlusion and cerebral infarction associated with Mycoplasma pneumonia infection in children. ( 27938350 )
2016
39
Central Retinal Artery Occlusion and Cerebral Infarction Following Stem Cell Injection for Baldness. ( 27941403 )
2016
40
Intra-arterial Thrombolysis for Central Retinal Artery Occlusion after the Coil Embolization of Paraclinoid Aneurysm. ( 28184347 )
2016
41
Central Retinal Artery Occlusion: A Literature Review and the Rationale for Hyperbaric Oxygen Therapy. ( 27039492 )
2016
42
Central Retinal Artery Occlusion With Subsequent Central Retinal Vein Occlusion in Biopsy-Proven Giant Cell Arteritis. ( 27261946 )
2016
43
Central Retinal Artery Occlusion in a Teenager. ( 27012699 )
2016
44
Spectral-Domain Optical Coherence Tomography Angiography of Central Retinal Artery Occlusion. ( 27183551 )
2016
45
CORRELATION OF OPTICAL INTENSITY ON OPTICAL COHERENCE TOMOGRAPHY AND VISUAL OUTCOME IN CENTRAL RETINAL ARTERY OCCLUSION. ( 26966866 )
2016
46
Central retinal artery occlusion, an early sign of crizotinib resistance in an alk positive adenocarcinoma of lung: A rare case report. ( 27606884 )
2016
47
Manifestations of central retinal artery occlusion revealed by fundus fluorescein angiography are associated with the degree of visual loss. ( 27313672 )
2016
48
Central Retinal Artery Occlusion after the Endovascular Treatment of Unruptured Ophthalmic Artery Aneurysm: A Case Report and a Literature Review. ( 28664002 )
2016
49
STRANGULATION-INDUCED CENTRAL RETINAL ARTERY OCCLUSION: CASE REPORT AND REVIEW OF THE LITERATURE. ( 27337704 )
2016
50
Ambient Air Pollution and the Risk of Central Retinal Artery Occlusion. ( 27745901 )
2016

Variations for Central Retinal Artery Occlusion

Expression for Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for Central Retinal Artery Occlusion

Pathways related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.11 PLAT PLG
2 10.95 PLAT PLG
3 10.84 PLAT PLG
4 10.32 PLAT PLG
5 9.74 PLAT PLG

GO Terms for Central Retinal Artery Occlusion

Cellular components related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ACTA2 HMOX1 PLAT PLG SERPINA10

Biological processes related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 9.16 PLG SERPINA10
2 blood coagulation GO:0007596 9.13 PLAT PLG SERPINA10
3 fibrinolysis GO:0042730 8.62 PLAT PLG

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 PLG TBCE

Sources for Central Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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