MCID: CNT028
MIFTS: 37

Central Retinal Artery Occlusion

Categories: Eye diseases, Cardiovascular diseases

Aliases & Classifications for Central Retinal Artery Occlusion

MalaCards integrated aliases for Central Retinal Artery Occlusion:

Name: Central Retinal Artery Occlusion 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13098
ICD10 33 H34.1
ICD9CM 35 362.31
MeSH 42 D015356
NCIt 47 C34456
SNOMED-CT 64 38742007
UMLS 69 C0007688

Summaries for Central Retinal Artery Occlusion

Disease Ontology : 12 A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.

MalaCards based summary : Central Retinal Artery Occlusion is related to retinitis and retinal artery occlusion. An important gene associated with Central Retinal Artery Occlusion is HMOX1 (Heme Oxygenase 1), and among its related pathways/superpathways are Cell adhesion_ECM remodeling and Cell adhesion_Plasmin signaling. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina.

Wikipedia : 72 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

Related Diseases for Central Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
id Related Disease Score Top Affiliating Genes
1 retinitis 11.1
2 retinal artery occlusion 11.1
3 lin-gettig syndrome 10.3 PLAT PLG
4 lateral myocardial infarction 10.3 PLAT PLG
5 egg allergy 10.3 PLAT PLG
6 neuropathy 10.3
7 internal auditory canal meningioma 10.3 PLAT PLG
8 coccidioidomycosis 10.3 PLAT PLG
9 hypopharynx cancer 10.3 PLAT PLG
10 barbiturate abuse 10.3 PLAT PLG
11 status asthmaticus 10.2 PLAT PLG
12 parasitic helminthiasis infectious disease 10.2 PLAT PLG
13 malignant hypertension 10.2 PLAT PLG
14 cerebritis 10.2
15 lupus erythematosus 10.2
16 ischemic optic neuropathy 10.2
17 churg-strauss syndrome 10.2
18 aryepiglottic fold cancer 10.1 PLAT PLG
19 retinal vein occlusion 10.1
20 systemic lupus erythematosus 10.1
21 haemophilus meningitis 10.1 PLAT PLG
22 aneurysm 10.1
23 sickle cell disease 10.1
24 lymphoma 10.1
25 thrombophilia due to activated protein c resistance 10.1 PLAT PLG
26 central retinal vein occlusion 10.0
27 susac syndrome 10.0
28 choroiditis 10.0
29 herpes zoster 10.0
30 branch retinal artery occlusion 10.0
31 ischemia 10.0
32 vasculitis 10.0
33 brill-zinsser disease 10.0 PLAT PLG
34 cellulitis 10.0
35 herpes zoster ophthalmicus 10.0
36 tuberculosis 10.0
37 carotid artery dissection 10.0
38 cervicitis 10.0
39 orbital cellulitis 10.0
40 polyarteritis nodosa 10.0
41 retinal ischemia 10.0
42 neovascular glaucoma 10.0
43 peripheral artery disease 9.9 ACTA2 PLAT PLG
44 cryptosporidiosis 9.9 FANCG PLG
45 homocystinuria 9.9
46 nonarteritic anterior ischemic optic neuropathy 9.9
47 hyperhomocysteinemia 9.9
48 protein s deficiency 9.9
49 nasopharyngitis 9.9
50 pneumonia 9.9

Comorbidity relations with Central Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to Central Retinal Artery Occlusion

Symptoms & Phenotypes for Central Retinal Artery Occlusion

Drugs & Therapeutics for Central Retinal Artery Occlusion

Drugs for Central Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4
3 Angiogenesis Modulating Agents Phase 4
4 insulin Phase 4
5 Insulin, Globin Zinc Phase 4
6
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
7
Salicylic acid Approved, Vet_approved Phase 3 69-72-7 338
8
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
9
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
10 Fibrinolytic Agents Phase 3,Phase 1
11 Plasminogen Phase 3,Phase 1
12 Tissue Plasminogen Activator Phase 3,Phase 1
13 Peripheral Nervous System Agents Phase 3,Phase 2
14 Neurotransmitter Agents Phase 3,Phase 2
15 Analgesics Phase 3
16 Analgesics, Non-Narcotic Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Anti-Inflammatory Agents, Non-Steroidal Phase 3
19 Antipyretics Phase 3
20 Antirheumatic Agents Phase 3
21 Cyclooxygenase Inhibitors Phase 3
22 Pharmaceutical Solutions Phase 3
23 Platelet Aggregation Inhibitors Phase 3
24 Adrenergic Agents Phase 3
25 Adrenergic Antagonists Phase 3
26 Adrenergic beta-Antagonists Phase 3
27 Anticoagulants Phase 3
28 Anticonvulsants Phase 3
29 calcium heparin Phase 3
30 Carbonic Anhydrase Inhibitors Phase 3
31 diuretics Phase 3
32 Natriuretic Agents Phase 3
33
Papaverine Approved Phase 2 61-25-6, 58-74-2 4680
34
Adenosine Approved, Investigational Phase 2 58-61-7 60961
35
Regadenoson Approved Phase 2 313348-27-5 219024
36 Moxaverine Investigational Phase 2 10539-19-2
37 Autonomic Agents Phase 2
38 Parasympatholytics Phase 2
39 Phosphodiesterase Inhibitors Phase 2
40 Vasodilator Agents Phase 2
41
Reteplase Approved Phase 1 133652-38-7 65820
42
Tenecteplase Approved Phase 1 191588-94-0
43
Bevacizumab Approved, Investigational 216974-75-3
44 Ophthalmic Solutions
45 Tetrahydrozoline

Interventional clinical trials:

(show all 22)

id Name Status NCT ID Phase Drugs
1 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4 ranibizumab
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Not yet recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 Hyperbaric Chamber for Central Retinal Vein Occlusion (CRVO) Patients Unknown status NCT02405741 Phase 2
6 Effects of Moxaverine and Placebo on Ocular Blood Flow Completed NCT00709423 Phase 2 Moxaverine;Moxaverin 150mg;NaCl
7 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Recruiting NCT03090087 Phase 2 Regadenoson
8 Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion Unknown status NCT01581411 Phase 1 Tissue Plasminogen Activator
9 Intravitreal Aflibercept Injection for Symptomatic Macular Edema From Retinal Artery Macroaneurysms Recruiting NCT02403128 Phase 1 aflibercept
10 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
11 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
12 OCT in Rare Chorioretinal Diseases Unknown status NCT02141308
13 Ocular Discomfort Assessment After Intravitreal Injections Completed NCT02806830 Optive
14 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102
15 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
16 Reconstruction of Pathological Changes of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Recruiting NCT02679716
17 Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome Recruiting NCT01481662
18 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245
19 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
20 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Not yet recruiting NCT02898480
21 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion Not yet recruiting NCT03061526
22 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

Anatomical Context for Central Retinal Artery Occlusion

MalaCards organs/tissues related to Central Retinal Artery Occlusion:

39
Eye, Brain, Retina, T Cells, Lung

Publications for Central Retinal Artery Occlusion

Articles related to Central Retinal Artery Occlusion:

(show top 50) (show all 477)
id Title Authors Year
1
The Penumbra Obscura Stimulates Iris Neovascularisation after Isolated Central Retinal Artery Occlusion. ( 28367049 )
2017
2
Systemic intravenous abciximab: a novel treatment for acute central retinal artery occlusion? ( 28470954 )
2017
3
Transient central retinal artery occlusion after sub-tenon's anaesthesia: Is it a safe technique? ( 28755793 )
2017
4
Optical Coherence Tomography Angiography of a Central Retinal Artery Occlusion Before and After Anterior Chamber Paracentesis. ( 28433123 )
2017
5
Triamcinolone emboli leading to central retinal artery occlusion: a multimodal imaging study. ( 28228436 )
2017
6
Iatrogenic central retinal artery occlusion after carotid body tumor embolization and excision. ( 28401029 )
2017
7
Disappearance of Myelinated Retinal Nerve Fibers after Central Retinal Artery Occlusion Reveals Nettleship Collaterals. ( 28823346 )
2017
8
Cystoid Macular Edema with Idiopathic Acute Central Retinal Artery Occlusion in a Healthy Child. ( 28791072 )
2017
9
Central retinal artery occlusion in a 30-year-old woman taking tranexamic acid. ( 28705840 )
2017
10
Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. ( 28096655 )
2017
11
Evaluation of Ophthalmic Artery Branch Retrograde Intervention in the Treatment of Central Retinal Artery Occlusion (CRAO). ( 28064304 )
2017
12
CENTRAL RETINAL ARTERY OCCLUSION WITH DOUBLE CILIORETINAL ARTERY SPARING. ( 28085758 )
2017
13
Update on the Management of Central Retinal Artery Occlusion. ( 27886897 )
2017
14
Hyperbaric, Central Retinal Artery Occlusion ( 28613728 )
2017
15
Is Intravenous Thrombolysis Safe and Effective in Central Retinal Artery Occlusion? A Critically Appraised Topic. ( 28644261 )
2017
16
Fusiform Left Carotid-Ophthalmic Artery Aneurysm Presenting with Central Retinal Artery Occlusion. ( 27865695 )
2017
17
Visual loss due to optic nerve infarction and central retinal artery occlusion after spine surgery in the prone position: A case report. ( 28767569 )
2017
18
Central retinal artery occlusion after percutaneous nephrolithotomy lithotripsy in the prone position. ( 28097535 )
2017
19
The efficacy of hyperbaric oxygen therapy in the treatment of central retinal artery occlusion. ( 28500127 )
2017
20
Carotid cavernous fistula with central retinal artery occlusion and Terson syndrome after mid-facial trauma. ( 28580223 )
2017
21
Management of acute central retinal artery occlusion: Intravenous thrombolysis is feasible and safe. ( 28067616 )
2017
22
PARACENTRAL ACUTE MIDDLE MACULOPATHY AND DEEP RETINAL CAPILLARY PLEXUS INFARCTION SECONDARY TO REPERFUSED CENTRAL RETINAL ARTERY OCCLUSION. ( 27668500 )
2017
23
Central Retinal Artery Occlusion by Left Atrial Myxoma. ( 28243029 )
2017
24
CENTRAL RETINAL ARTERY OCCLUSION IN A YOUNG HIV-INFECTED PATIENT ON HIGHLY ACTIVE ANTIRETROVIRAL THERAPY. ( 27111556 )
2016
25
Intra-arterial Thrombolysis for Central Retinal Artery Occlusion after the Coil Embolization of Paraclinoid Aneurysm. ( 28184347 )
2016
26
Multimodal imaging of central retinal artery occlusion with retained cilioretinal perfusion. ( 27530879 )
2016
27
Central Retinal Artery Occlusion: A Literature Review and the Rationale for Hyperbaric Oxygen Therapy. ( 27039492 )
2016
28
STRANGULATION-INDUCED CENTRAL RETINAL ARTERY OCCLUSION: CASE REPORT AND REVIEW OF THE LITERATURE. ( 27337704 )
2016
29
Central retinal artery occlusion, an early sign of crizotinib resistance in an alk positive adenocarcinoma of lung: A rare case report. ( 27606884 )
2016
30
Ambient Air Pollution and the Risk of Central Retinal Artery Occlusion. ( 27745901 )
2016
31
Central Retinal Artery Occlusion and Cerebral Infarction Following Stem Cell Injection for Baldness. ( 27941403 )
2016
32
Central Retinal Artery Occlusion after the Endovascular Treatment of Unruptured Ophthalmic Artery Aneurysm: A Case Report and a Literature Review. ( 28664002 )
2016
33
Necrotizing Fasciitis of the Periorbital Region Complicated by Combined Central Retinal Artery Occlusion, Central Retinal Vein Occlusion, and Posterior Ciliary Occlusion. ( 27556345 )
2016
34
Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion. ( 27698763 )
2016
35
Incidence and Clinical Features of Neovascularization of the Iris following Acute Central Retinal Artery Occlusion. ( 27729755 )
2016
36
Comparison of hyperbaric oxygen versus iloprost treatment in an experimental rat central retinal artery occlusion model. ( 27480178 )
2016
37
Central retinal artery occlusion after phacoemulsification under peribulbar anaesthesia: Pathogenic hypothesis. ( 26652970 )
2016
38
Manifestations of central retinal artery occlusion revealed by fundus fluorescein angiography are associated with the degree of visual loss. ( 27313672 )
2016
39
Spectral-Domain Optical Coherence Tomography Angiography of Central Retinal Artery Occlusion. ( 27183551 )
2016
40
Central Retinal Artery Occlusion Masquerading as Branch Retinal Artery Occlusion. ( 27729760 )
2016
41
Early Onset of Ocular Neovascularization After Hyperbaric Oxygen Therapy in a Patient With Central Retinal Artery Occlusion. ( 27613631 )
2016
42
Embolic Central Retinal Artery Occlusion Detected with Point-of-care Ultrasonography in the Emergency Department. ( 26879704 )
2016
43
Central Retinal Artery Occlusion in Takayasu's Arteritis as the First Presentation of the Disease. ( 27867673 )
2016
44
CORRELATION OF OPTICAL INTENSITY ON OPTICAL COHERENCE TOMOGRAPHY AND VISUAL OUTCOME IN CENTRAL RETINAL ARTERY OCCLUSION. ( 26966866 )
2016
45
Central Retinal Artery Occlusion in a Teenager. ( 27012699 )
2016
46
Central Retinal Artery Occlusion With Subsequent Central Retinal Vein Occlusion in Biopsy-Proven Giant Cell Arteritis. ( 27261946 )
2016
47
Central retinal artery occlusion as a presenting manifestation of polycythaemia vera. ( 27797860 )
2016
48
Visual Improvement after Intra-Arterial Thrombolysis for Central Retinal Artery Occlusion Does Not Correlate with Time to Treatment. ( 27781041 )
2016
49
Central retinal artery occlusion and cerebral infarction associated with Mycoplasma pneumonia infection in children. ( 27938350 )
2016
50
Central retinal artery occlusion following orbital tumor resection: Is rapid intervention effective? ( 26576528 )
2015

Variations for Central Retinal Artery Occlusion

Expression for Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for Central Retinal Artery Occlusion

Pathways related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.11 PLAT PLG
2 10.95 PLAT PLG
3 10.84 PLAT PLG
4 10.37 PLAT PLG
5 9.74 PLAT PLG

GO Terms for Central Retinal Artery Occlusion

Cellular components related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ACTA2 HMOX1 PLAT PLG SERPINA10

Biological processes related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.26 ACTA2 HMOX1
2 hemostasis GO:0007599 9.16 PLG SERPINA10
3 blood coagulation GO:0007596 9.13 PLAT PLG SERPINA10
4 fibrinolysis GO:0042730 8.62 PLAT PLG

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 PLG TBCE

Sources for Central Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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