MCID: CNT016
MIFTS: 53

Central Retinal Vein Occlusion malady

Cardiovascular diseases category

Summaries for Central Retinal Vein Occlusion

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63Wikipedia, 32MalaCards
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Wikipedia:63 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards: Central Retinal Vein Occlusion is related to retinal vein occlusion and macular retinal edema. An important gene associated with Central Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Senescence and Autophagy and Dissolution of Fibrin Clot. The compounds estrogen and warfarin have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are cardiovascular system and vision/eye.

Aliases & Classifications for Central Retinal Vein Occlusion

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

central retinal vein occlusion 8 10 44 60


External Ids:

Disease Ontology8 DOID:2450
SNOMED-CT56 193378003, 68478007
ICD9CM27 362.35

Related Diseases for Central Retinal Vein Occlusion

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17GeneCards, 18GeneDecks
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Diseases in the Retinal Vein Occlusion family:

central retinal vein occlusion

Diseases related to Central Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 249)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vein occlusion32.3APOH, F5, MTHFR, VEGFA, SERPINC1
2macular retinal edema31.8VEGFA, SERPINF1
3retinal artery occlusion31.3APOH
4central retinal artery occlusion31.3PLAT
5retinal vascular occlusion31.3APOH, F5
6glaucoma31.2SERPINF1
7hyperhomocysteinemia31.1MTHFR, VWF, F2, PLAT, SERPINE1, SERPINC1
8retinal detachment31.1SERPINF1, PLAT, VEGFA
9retinal disease30.9F8, VEGFA, VWF, SERPINE1, SERPINF1
10macular holes30.8SERPINF1
11hypertension30.8F5, MTHFR, F2, PLAT, SERPINE1
12branch retinal artery occlusion30.8F5
13purpura30.8SERPINC1
14thrombophilia30.7APOH, F8, F5, MTHFR, VWF, F2
15vasculitis30.7F2, VWF, APOH
16leukemia30.6F8, JAK2, MTHFR, IL6, SERPINF1
17protein s deficiency30.6APOH, F8, F5, MTHFR, F2, SERPINE1
18hemolytic-uremic syndrome30.5VWF
19myeloid leukemia30.5JAK2
20multiple myeloma30.5IL6
21hepatitis30.5F2, F8
22psoriasis30.5IL6
23hepatitis c30.5F8, F2
24factor v deficiency30.5F8, F5, F2
25lupus erythematosus30.5APOH, F5, F2, SERPINC1
26myeloma30.5JAK2, VEGFA, IL6
27deficiency anemia30.5G6PD, JAK2, IL6, VWF, F2
28systemic lupus erythematosus30.5F2, VWF, IL6, F8, APOH
29hemoglobinuria30.3G6PD
30cystic fibrosis30.3F8
31factor xii deficiency30.3F5
32migraine30.3MTHFR, APOH
33sneddon syndrome30.3APOH, SERPINC1
34eclampsia30.3MTHFR, SERPINC1
35acute leukemia30.3MTHFR, JAK2
36inflammatory bowel disease30.3IL6
37pneumonia30.3IL6
38arthritis30.3IL6
39sickle cell disease30.3G6PD, VWF
40hemophilia b30.3F2, F8
41colon cancer30.3VEGFA, MTHFR, JAK2
42retinal vascular disease30.3VEGFA, SERPINF1
43diabetic retinopathy30.3SERPINF1, SERPINE1, VEGFA
44antithrombin iii deficiency30.3SERPINC1, F2, MTHFR, APOH, F5
45von willebrand's disease30.3F2, VWF, F5, F8
46protein c deficiency30.3APOH, F5, MTHFR, F2, SERPINE1, SERPINC1
47rheumatoid arthritis30.3APOH, JAK2, MTHFR, VEGFA, IL6
48hellp syndrome30.3APOH, F5, MTHFR, VWF, SERPINE1, SERPINC1
49thrombocytosis30.3JAK2, IL6, VWF, F2, SERPINC1
50vascular disease30.3VEGFA, IL6, VWF, SERPINC1, JAK2, F8

Graphical network of the top 20 diseases related to Central Retinal Vein Occlusion:



Diseases related to central retinal vein occlusion

Clinical Features for Central Retinal Vein Occlusion

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Drugs & Therapeutics for Central Retinal Vein Occlusion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Central Retinal Vein Occlusion

Drug clinical trials:

Search ClinicalTrials for Central Retinal Vein Occlusion

Search NIH Clinical Center for Central Retinal Vein Occlusion

Search CenterWatch for Central Retinal Vein Occlusion

Genetic Tests for Central Retinal Vein Occlusion

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Anatomical Context for Central Retinal Vein Occlusion

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32MalaCards
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MalaCards organs/tissues related to Central Retinal Vein Occlusion:

32
Retina, Eye, Endothelial, Myeloid, Colon, Liver, Skin

Animal Models for Central Retinal Vein Occlusion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Central Retinal Vein Occlusion:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.4G6PD, F2, SERPINF1
2MP:00053919.4SERPINF1, PLAT
3MP:00107718.9VEGFA, IL6, F2
4MP:00036318.8F5, F2, PLAT, SERPINC1, SERPINF1
5MP:00053898.8F8, MTHFR, VEGFA, SERPINC1, SERPINF1
6MP:00053908.7PLAT, IL6, VEGFA, JAK2
7MP:00053817.4VEGFA, IL6, VWF, F2, PLAT, SERPINF1
8MP:00053786.9G6PD, JAK2, F5, MTHFR, VEGFA, IL6
9MP:00053876.5F8, JAK2, VEGFA, IL6, VWF, F2
10MP:00053976.2F8, G6PD, JAK2, VEGFA, IL6, VWF
11MP:00053765.5SERPINC1, APOH, F8, G6PD, JAK2, F5
12MP:00107685.5F5, JAK2, G6PD, F8, APOH, MTHFR

Publications for Central Retinal Vein Occlusion

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50PubMed
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Articles related to Central Retinal Vein Occlusion:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Prospective study of peripheral panretinal photocoagulation of areas of nonperfusion in central retinal vein occlusion. (23269405)
2013
2
A prospective, randomised, multicenter trial for surgical treatment of central retinal vein occlusion: results of the Radial Optic Neurotomy for Central Vein Occlusion (ROVO) study group. (22960949)
2013
3
Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1-year results from the phase 3 COPERNICUS study. (23218699)
2013
4
Acute central retinal vein occlusion following episode of myopericarditis in an adolescent patient. (23907977)
2013
5
Aflibercept: newly approved for the treatment of macular edema following central retinal vein occlusion. (23673531)
2013
6
Cytomegalovirus retinitis after central retinal vein occlusion in a patient on systemic immunosuppression: does venooclusive disease predispose to cytomegalovirus retinitis in patients already at risk? (22570539)
2012
7
Critical appraisal of the clinical utility of the dexamethasone intravitreal implant (Ozurdex) for the treatment of macular edema related to branch retinal vein occlusion or central retinal vein occlusion. (21845032)
2011
8
A woman with unilateral sudden painless vision loss. Left central retinal vein occlusion. (22018104)
2011
9
Malignant glaucoma and central retinal vein occlusion after Nd: YAG laser posterior capsulotomy. (22256568)
2011
10
Long-term effects of vitrectomy and internal limiting membrane peeling for macular edema secondary to central retinal vein occlusion and hemiretinal vein occlusion. (19996831)
2010
11
Aqueous humor nitric oxide in patients with central retinal vein occlusion. (20884370)
2010
12
Central retinal vein occlusion following Sirsasana (headstand posture). (19075418)
2009
13
Ocular blood flow levels and visual prognosis in a patient with nonischemic type central retinal vein occlusion. (19750123)
2009
14
Pars plana vitrectomy, internal limiting membrane peeling, and panretinal endophotocoagulation for macular edema secondary to central retinal vein occlusion. (19193361)
2009
15
Pegaptanib sodium for macular edema secondary to central retinal vein occlusion. (19365011)
2009
16
Secondary macular hole associated with central retinal vein occlusion treated with corticosteroid injection. (19484453)
2009
17
Branch Retinal Vein Occlusion followed by Central Retinal Vein Occlusion. (23056675)
2009
18
Familial central retinal vein occlusion. (17173011)
2008
19
Central retinal vein occlusion with non-arteritic ischemic optic neuropathy and cystoid macular edema. (18491126)
2008
20
Hyperhomocysteinemia and central retinal vein occlusion in Iranian population. (17636432)
2008
21
Rapid improvement of retinal and iris neovascularization after a single intravitreal bevacizumab injection in a patient with central retinal vein occlusion and neovascular glaucoma. (17609852)
2008
22
Leuprolide acetate and central retinal vein occlusion. (18050813)
2007
23
Early treatment of severe cystoid macular edema in central retinal vein occlusion with posterior sub-tenon triamcinolone acetonide. (17290200)
2007
24
Effect of oral pentoxifylline on cystoid macular edema associated with central retinal vein occlusion. (18040238)
2007
25
Laser chorioretinal venous anastomosis for progressive nonischemic central retinal vein occlusion. (16515021)
2005
26
Retinal endovascular surgery for central retinal vein occlusion: initial experience of four surgeons. (16077361)
2005
27
Noninfectious hypopion after intravitreal triamcinolone acetonide injection for central retinal vein occlusion: a case report. (16302450)
2005
28
Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for macular edema from central retinal vein occlusion. (16156153)
2005
29
Nonischemic central retinal vein occlusion associated with celiac disease. (15704767)
2005
30
The question of radial optic neurotomy in central retinal vein occlusion. (15477488)
2004
31
Medical and surgical management of central retinal vein occlusion. (14704516)
2004
32
Choroidal neovascularization after radial optic neurotomy for central retinal vein occlusion. (15300083)
2004
33
Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. (14707827)
2003
34
Vision-related quality of life in people with central retinal vein occlusion using the 25-item National Eye Institute Visual Function Questionnaire. (12963613)
2003
35
A pilot study of pars plana vitrectomy, intraocular gas, and radial neurotomy in ischaemic central retinal vein occlusion. (12928281)
2003
36
Laser induced chorioretinal venous anastomosis in ischaemic central retinal vein occlusion. (12881352)
2003
37
Intravitreous triamcinolone acetonide as treatment for macular edema from central retinal vein occlusion. (12215101)
2002
38
Intravitreal injection of tissue plasminogen activator for central retinal vein occlusion. (11797310)
2001
39
Successful erbium: YAG laser-induced chorioretinal venous anastomosis for the management of ischemic central retinal vein occlusion. A report of two cases. (11789869)
2001
40
Bilateral central retinal vein occlusion in Eisenmenger syndrome. (11476697)
2001
41
Simultaneous bilateral central retinal vein occlusion associated with anticardiolipin antibodies in leukemia. (11476696)
2001
42
Prevalence of factor V Leiden and activated protein C resistance in central retinal vein occlusion. (11321143)
2001
43
Central retinal vein occlusion associated with primary pulmonary hypertension. (11217943)
2001
44
Retinal surgery for treatment of central retinal vein occlusion. (10743932)
2000
45
Hyperhomocysteinemia: a risk factor for central retinal vein occlusion. (10844057)
2000
46
Hyperhomocystinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. (10919914)
2000
47
Investigation of blood flow velocity by color Doppler imaging in nonischemic central retinal vein occlusion with collateral veins. (11094189)
2000
48
Cilioretinal artery occlusion with central retinal vein occlusion. (10566858)
1999
49
Acute central retinal vein occlusion successfully treated with intravenous thrombolysis. (10636648)
1999
50
Experimental retinal vascular occlusion. II. A clinico-pathologic correlative study of simultaneous occlusion of central retinal vein and artery. (3721721)
1986

Genetic Variations for Central Retinal Vein Occlusion

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Expression for genes affiliated with Central Retinal Vein Occlusion

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Retinal Vein Occlusion

Search GEO for disease gene expression data for Central Retinal Vein Occlusion.

Pathways for genes affiliated with Central Retinal Vein Occlusion

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore, 29KEGG, 52R&D Systems
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Pathways related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0SERPINE1
29.7SERPINE1, PLAT
3
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9.5SERPINF1, JAK2
4
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9.4F5, F2, SERPINC1
5
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9.4VWF, F2
6
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9.2F8, JAK2, F5, VEGFA
7
Translation Insulin regulation of translation
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9.0JAK2, VEGFA, PLAT, SERPINE1
8
Immune response Oncostatin M signaling via JAK-Stat in human cells
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8.9IL6, VEGFA, JAK2
98.8SERPINE1, IL6, VEGFA
10
Development PDGF signaling via STATs and NF-kB
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8.8F2, IL6, JAK2
11
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8.7SERPINE1, IL6, JAK2
12
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8.5SERPINC1, SERPINE1, F2, F5, F8
13
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8.4F8, F5, VEGFA, VWF, SERPINE1
148.3JAK2, VEGFA, IL6, VWF
158.1SERPINE1, PLAT, F2, IL6, MTHFR
16
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7.6SERPINC1, F8, F5, VWF, F2, PLAT
17
Hide members
7.6F8, F5, VWF, F2, PLAT, SERPINE1

Compounds for genes affiliated with Central Retinal Vein Occlusion

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 191)
idCompoundScoreTop Affiliating Genes
1estrogen4410.3APOH, F8
2warfarin44 49 11 2412.7SERPINC1, VWF, APOH
3creatinine449.6APOH, F8, F5, F2
4spectrozyme449.5F2, F5, PLAT, SERPINC1
5kaolin449.5F8, APOH, F2, F5
6fondaparinux449.5F5, PLAT, SERPINC1, F2
7bivalirudin44 1110.5F5, F2, PLAT, SERPINC1
8argatroban44 1110.5F2, SERPINC1, F5, PLAT
9phosphatidylserine44 28 1111.4F8, APOH, F2
10protamine sulfate449.4F5, F2, PLAT, SERPINC1
11batroxobin449.4F5, SERPINE1, PLAT, F2
12aspartate449.3F2, JAK2, G6PD, F8
13serine449.2JAK2, SERPINF1, G6PD, F8
14Drotrecogin alfa119.2F8, F5, F2, SERPINE1
15heparin44 28 11 2412.2VEGFA, SERPINF1, MTHFR, F8, APOH
16pge1449.1APOH, F5, F2, PLAT, SERPINE1
17ancrod449.1F2, F5, SERPINC1, SERPINE1, PLAT
18ppack449.0PLAT, VWF, F2, SERPINC1
19gabexate mesilate449.0IL6, PLAT, F5, SERPINC1
20hydroxyethyl starch449.0SERPINC1, F2, VWF, F8
21dextran sulfate449.0IL6, F5, JAK2, APOH
22cyclosporin a44 28 5910.9F2, JAK2, F8
2311-dehydrothromboxane b2448.9VWF, F2, SERPINE1, APOH
24aprotinin44 119.9SERPINC1, F5, VWF, PLAT, SERPINE1
25vitamin b12448.9F5, APOH, G6PD, MTHFR, VWF
26tirofiban44 119.9SERPINC1, PLAT, F2, VWF
27dermatan sulfate448.8F2, SERPINC1, VWF, F5, PLAT
28cyclophosphamide44 49 1110.8F5, APOH, F8, G6PD, MTHFR, VWF
29perindopril44 49 1110.8VWF, SERPINE1, PLAT, VEGFA
30ristocetin448.6F2, VWF, F5, PLAT, SERPINC1, F8
31folate448.6MTHFR, F5, G6PD, APOH, SERPINC1, VWF
32citrate448.4SERPINC1, F2, VWF, F5, G6PD, F8
33dexamethasone44 49 28 1111.4VEGFA, SERPINF1, IL6, F8
34ascorbic acid44 249.3JAK2, PLAT, MTHFR, F5, G6PD, SERPINC1
35tranexamic acid44 119.3F2, VWF, F8, SERPINC1, SERPINE1, PLAT
36protamine448.2SERPINE1, SERPINC1, F5, PLAT, F2, IL6
37kininogen448.2SERPINC1, SERPINE1, F2, VWF, F5, PLAT
38desmopressin44 59 28 1111.1F2, VWF, F5, F8, PLAT, SERPINE1
39hirudin448.1SERPINC1, SERPINE1, PLAT, F2, VWF, F5
40atorvastatin44 49 28 11 2412.0PLAT, VWF, IL6, VEGFA, F5, SERPINE1
41endotoxin448.0APOH, JAK2, F5, IL6, SERPINE1, F8
42prostacyclin448.0PLAT, F8, SERPINC1, SERPINE1, APOH, VWF
43simvastatin44 49 59 28 11 2412.6IL6, F2, F5, PLAT, VEGFA, SERPINE1
44epinephrine44 11 249.6VWF, JAK2, F5, G6PD, F8, F2
45homocysteine44 248.6APOH, F5, MTHFR, VWF, F8, F2
46n acetylcysteine447.1G6PD, JAK2, VEGFA, IL6, VWF, SERPINF1
47cholesterol44 28 11 2410.1F8, APOH, IL6, SERPINE1, MTHFR, F5
48aspirin44 49 28 249.8SERPINC1, SERPINE1, APOH, F8, G6PD, JAK2
49fibrinogen446.7SERPINC1, SERPINE1, PLAT, F2, VWF, MTHFR
50vegf446.5APOH, SERPINC1, SERPINE1, VWF, VEGFA, JAK2

GO Terms for genes affiliated with Central Retinal Vein Occlusion

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16Gene Ontology
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Cellular components related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.3F8, F5, VEGFA, VWF, SERPINE1
2extracellular matrixGO:0310128.3VWF, PLAT, SERPINE1, SERPINF1, APOH
3extracellular spaceGO:0056156.4SERPINF1, APOH, F8, F5, VEGFA, IL6
4extracellular regionGO:0055765.7F8, F5, VEGFA, IL6, VWF, F2

Biological processes related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.1PLAT, APOH
2negative regulation of proteolysisGO:0458619.8PLAT, F2
3negative regulation of blood coagulationGO:0301959.6APOH, SERPINE1
4negative regulation of fibrinolysisGO:0519189.5SERPINE1, F2, APOH
5positive regulation of blood coagulationGO:0301949.5APOH, F2, SERPINE1
6fibrinolysisGO:0427309.5SERPINE1, PLAT, F2
7positive regulation of protein import into nucleus, translocationGO:0331609.3IL6, JAK2
8negative regulation of endopeptidase activityGO:0109519.3SERPINF1, SERPINC1, SERPINE1
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1JAK2, VEGFA, IL6
10blood coagulation, intrinsic pathwayGO:0075979.1F2, VWF, F8, APOH
11acute-phase responseGO:0069539.0F8, IL6, F2
12regulation of cell shapeGO:0083608.9F2, IL6, VEGFA
13platelet degranulationGO:0025768.7F8, F5, VEGFA, VWF, SERPINE1
14positive regulation of cell proliferationGO:0082848.2F2, IL6, VEGFA, JAK2
15platelet activationGO:0301687.4F8, F5, VEGFA, IL6, VWF, F2
16blood coagulationGO:0075967.2SERPINC1, F8, JAK2, F5, VEGFA, VWF

Molecular functions related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.6SERPINC1, VEGFA, APOH
2protease bindingGO:0020208.9VWF, SERPINE1, SERPINC1
3serine-type endopeptidase inhibitor activityGO:0048678.8SERPINF1, SERPINC1, SERPINE1
4protein bindingGO:0055156.4SERPINC1, APOH, F8, G6PD, JAK2, F5

Products for genes affiliated with Central Retinal Vein Occlusion

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Retinal Vein Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet