MCID: CNT016
MIFTS: 50

Central Retinal Vein Occlusion malady

Cardiovascular category

Summaries for Central Retinal Vein Occlusion

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards: Central Retinal Vein Occlusion is related to central retinal artery occlusion and hyperhomocysteinemia. An important gene associated with Central Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Senescence and Autophagy and Dissolution of Fibrin Clot. The compounds estrogen and warfarin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and retina, and related mouse phenotypes are cardiovascular system and vision/eye.

Aliases & Classifications for Central Retinal Vein Occlusion

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

central retinal vein occlusion 8 10 45 61


External Ids:

Disease Ontology8 DOID:2450
SNOMED-CT57 193378003, 68478007
ICD9CM27 362.35

Related Diseases for Central Retinal Vein Occlusion

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the retinal vein occlusion family:

central retinal vein occlusion

Diseases related to Central Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1central retinal artery occlusion31.3PLAT
2hyperhomocysteinemia31.1MTHFR, VWF, F2, PLAT, SERPINE1, SERPINC1
3protein c deficiency30.8APOH, F5, MTHFR, F2, SERPINE1, SERPINC1
4thrombophilia30.8APOH, F8, F5, MTHFR, VWF, F2
5branch retinal artery occlusion30.7F5
6factor v deficiency30.7F8, F5, F2
7vasculitis30.7F2, VWF, APOH
8hemolytic-uremic syndrome30.6VWF
9hepatitis a30.6F2, F8
10hepatitis c30.6F8, F2
11deficiency anemia30.5G6PD, JAK2, IL6, VWF, F2
12systemic lupus erythematosus30.5F2, VWF, IL6, F8, APOH
13nephritis30.4APOH
14hemoglobinuria30.4G6PD
15cystic fibrosis30.4F8
16sneddon syndrome30.4APOH, SERPINC1
17eclampsia30.4MTHFR, SERPINC1
18macular holes30.4SERPINF1
19acute leukemia30.3MTHFR, JAK2
20hepatitis b30.3F8, F2
21arthritis30.3IL6
22sickle cell disease30.3G6PD, VWF
23thrombotic thrombocytopenic purpura, acquired30.3APOH, F8, VWF, SERPINE1
24hellp syndrome30.3APOH, F5, MTHFR, VWF, SERPINE1, SERPINC1
25protein s deficiency30.3APOH, F8, F5, MTHFR, F2, SERPINE1
26thrombocytosis30.3JAK2, IL6, VWF, F2, SERPINC1
27vascular disease30.3VEGFA, IL6, VWF, SERPINC1, JAK2, F8
28neovascular glaucoma10.7
29cystoid macular edema10.7
30vein disease10.7
31thrombotic thrombocytopenic purpura10.6
32protein r deficiency10.6
33ischemic neuropathy10.5
34ischemic optic neuropathy10.5
35retinal vasculitis10.5
36tuberculosis10.5
37cytomegalovirus retinitis10.5
38primary pulmonary hypertension10.4
39macroglobulinemia10.4
40primary open angle glaucoma10.4
41iron deficiency anemia10.4
42vitreous detachment10.4
43rubeosis iridis10.4
44ischemic retinopathy10.3
45pulmonary tuberculosis10.3
46retinal drusen10.3
47pseudotumor cerebri10.3
48exfoliation syndrome10.3
49posterior scleritis10.3
50acute myeloid leukemia10.3

Graphical network of the top 20 diseases related to Central Retinal Vein Occlusion:



Diseases related to central retinal vein occlusion

Clinical Features for Central Retinal Vein Occlusion

Drugs & Therapeutics for Central Retinal Vein Occlusion

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Central Retinal Vein Occlusion

Drug clinical trials:

Search ClinicalTrials for Central Retinal Vein Occlusion

Search NIH Clinical Center for Central Retinal Vein Occlusion

Search CenterWatch for Central Retinal Vein Occlusion

Genetic Tests for Central Retinal Vein Occlusion

Anatomical Context for Central Retinal Vein Occlusion

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Central Retinal Vein Occlusion:

33
Skin, Liver, Retina, Colon, Myeloid, B lymphoblasts, B cells, Endothelial

Animal Models for Central Retinal Vein Occlusion or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Central Retinal Vein Occlusion

Sources:
51PubMed
See all sources

Articles related to Central Retinal Vein Occlusion:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Retinal vessel tortuosity associated with central retinal vein occlusion: an optical coherence tomography study. (24327610)
2014
2
Comparative effectiveness of the dexamethasone intravitreal implant in vitrectomized and non-vitrectomized eyes with macular edema secondary to central retinal vein occlusion. (23418731)
2013
3
VEGF Trap-Eye for macular oedema secondary to central retinal vein occlusion: 6-month results of the phase III GALILEO study. (23298885)
2013
4
Reading Center Characterization of Central Retinal Vein Occlusion Using Optical Coherence Tomography During the COPERNICUS Trial. (24381819)
2013
5
Dexamethasone implants and neovascular glaucoma in central retinal vein occlusion. (23241218)
2013
6
Mortality in Patients with Central Retinal Vein Occlusion. (24053999)
2013
7
Intravitreous bevacizumab treatment for macular edema due to central retinal vein occlusion. (22668313)
2012
8
Combined anterior and posterior scleritis associated with central retinal vein occlusion: a case report. (22411459)
2012
9
Vascular endothelial growth factor Trap-Eye for macular edema secondary to central retinal vein occlusion: six-month results of the phase 3 COPERNICUS study. (22440275)
2012
10
Longer-term outcomes of a prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. (21317833)
2011
11
Predictors of short-term visual outcome after anti-VEGF therapy of macular edema due to central retinal vein occlusion. (21087958)
2011
12
Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study. (21552499)
2011
13
Intravitreal ranibizumab for macular edema secondary to central retinal vein occlusion. (21283055)
2011
14
Role of inflammation-related gene polymorphisms in patients with central retinal vein occlusion. (21269700)
2011
15
Ischemic index and neovascularization in central retinal vein occlusion. (21099454)
2011
16
Intravitreal bevacizumab for treatment of serous macular detachment in central retinal vein occlusion. (21053008)
2011
17
Peripheral areas of nonperfusion in treated central retinal vein occlusion as imaged by wide-field fluorescein angiography. (21487338)
2011
18
Intravitreal bevacizumab for macular edema due to central retinal vein occlusion: perfused vs. ischemic and early vs. late treatment. (21978179)
2011
19
Focal macular electroretinogram in macular edema secondary to central retinal vein occlusion. (21398283)
2011
20
Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion. (21538000)
2011
21
Electrophysiological evaluation and visual outcome in patients with central retinal vein occlusion, primary open-angle glaucoma and neovascular glaucoma. (19432876)
2010
22
Branch retinal artery occlusion and non-ischemic central retinal vein occlusion due to hyperhomocysteinemia in a 14-year-old child. (21158360)
2010
23
Aqueous humor levels of vasoactive molecules correlate with vitreous levels and macular edema in central retinal vein occlusion. (19967679)
2010
24
Early intravitreal bevacizumab for non-ischaemic central retinal vein occlusion. (18937800)
2009
25
Ischaemic change after intravitreal bevacizumab (Avastin) injection for macular oedema secondary to non-ischaemic central retinal vein occlusion. (18494740)
2008
26
Combined central retinal artery and vein occlusion complicating orbital cellulitis. (18689145)
2008
27
Long-term safety and efficacy of intravitreal bevacizumab (Avastin) for the management of central retinal vein occlusion. (19430392)
2008
28
Central retinal vein occlusion as a possible presenting manifestation of Sneddon syndrome. (17895826)
2007
29
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
30
Biometric indices evaluation in central retinal vein occlusion using partial coherence laser interferometry. (17534821)
2007
31
Chronic angle-closure glaucoma secondary to a suprachoroidal effusion induced by central retinal vein occlusion. (17552395)
2007
32
Panretinal photocoagulation and photodynamic therapy for anterior segment neovascularization secondary to ischemic central retinal vein occlusion. (17396687)
2007
33
Intractable glaucoma following posterior sub-tenon's triamcinolone acetonide for central retinal vein occlusion in a young adult. (16601743)
2006
34
Radial optic neurotomy for central retinal vein occlusion: 117 consecutive cases. (16508430)
2006
35
Controversies regarding radial optic neurotomy for central retinal vein occlusion. (16199974)
2005
36
Intravitreal triamcinolone acetonide for treatment of central retinal vein occlusion. (16329061)
2005
37
Role of early radial optic neurotomy in central retinal vein occlusion. (15976467)
2005
38
Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion. (15013911)
2004
39
Perivenular macular whitening during acute central retinal vein occlusion. (14557193)
2003
40
Recurrent central retinal vein occlusion in a young thrombophilic patient with factor V Leiden mutation. (12022286)
2002
41
Retinal oxygen saturation levels in patients with central retinal vein occlusion. (12153805)
2002
42
Central retinal vein occlusion in a patient with rheumatoid arthritis taking rofecoxib. (12384019)
2002
43
Central retinal vein occlusion associated with Sturge Weber syndrome. (12194091)
2002
44
Branch retinal artery obstruction with simultaneous central retinal vein occlusion. (11339596)
2001
45
The heterozygous 20210 G/A genotype prevalence in patients affected by central and branch retinal vein occlusion: a pilot study. (11450488)
2001
46
The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 in patients with central retinal vein occlusion. (10593436)
1999
47
The a- and b-wave latencies as a prognostic indicator of neovascularisation in central retinal vein occlusion. (11097117)
1999
48
Macular edema in retinal vein occlusion: up-date from the central retinal vein occlusion study. (10896341)
1999
49
Central retinal vein occlusion associated with cryofibrinogenemia in a young adult--study of skin dynamic capillaroscopy. (9872035)
1998
50
Screening for resistance to activated protein C and the mutant gene for factor V:Q506 in patients with central retinal vein occlusion. (9372721)
1997

Genetic Variations for Central Retinal Vein Occlusion

Expression for genes affiliated with Central Retinal Vein Occlusion

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Central Retinal Vein Occlusion

Search GEO for disease gene expression data for Central Retinal Vein Occlusion.

Pathways for genes affiliated with Central Retinal Vein Occlusion

Sources:
38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 12EMD Millipore, 30KEGG, 53R&D Systems
See all sources

Pathways related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0SERPINE1
29.7SERPINE1, PLAT
3
Hide members
9.5SERPINF1, JAK2
4
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9.4F5, F2, SERPINC1
5
Hide members
9.4VWF, F2
6
Hide members
9.2F8, JAK2, F5, VEGFA
7
Translation Insulin regulation of translation
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9.0JAK2, VEGFA, PLAT, SERPINE1
8
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
8.9IL6, VEGFA, JAK2
98.8SERPINE1, IL6, VEGFA
10
Development PDGF signaling via STATs and NF-kB
Hide members
8.8F2, IL6, JAK2
11
Hide members
8.7SERPINE1, IL6, JAK2
12
Hide members
8.5SERPINC1, SERPINE1, F2, F5, F8
13
Hide members
8.4F8, F5, VEGFA, VWF, SERPINE1
148.3JAK2, VEGFA, IL6, VWF
158.1SERPINE1, PLAT, F2, IL6, MTHFR
16
Hide members
7.6SERPINC1, F8, F5, VWF, F2, PLAT
17
Hide members
7.6F8, F5, VWF, F2, PLAT, SERPINE1

Compounds for genes affiliated with Central Retinal Vein Occlusion

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 191)
idCompoundScoreTop Affiliating Genes
1estrogen4510.3APOH, F8
2warfarin45 50 11 2412.7SERPINC1, VWF, APOH
3creatinine459.6APOH, F8, F5, F2
4spectrozyme459.5F2, F5, PLAT, SERPINC1
5kaolin459.5F8, APOH, F2, F5
6fondaparinux459.5F5, PLAT, SERPINC1, F2
7bivalirudin45 1110.5F5, F2, PLAT, SERPINC1
8argatroban45 1110.5F2, SERPINC1, F5, PLAT
9phosphatidylserine45 29 1111.4F8, APOH, F2
10protamine sulfate459.4F5, F2, PLAT, SERPINC1
11batroxobin459.4F5, SERPINE1, PLAT, F2
12aspartate459.3F2, JAK2, G6PD, F8
13serine459.2JAK2, SERPINF1, G6PD, F8
14Drotrecogin alfa119.2F8, F5, F2, SERPINE1
15heparin45 29 11 2412.2VEGFA, SERPINF1, MTHFR, F8, APOH
16pge1459.1APOH, F5, F2, PLAT, SERPINE1
17ancrod459.1F2, F5, SERPINC1, SERPINE1, PLAT
18ppack459.0PLAT, VWF, F2, SERPINC1
19gabexate mesilate459.0IL6, PLAT, F5, SERPINC1
20hydroxyethyl starch459.0SERPINC1, F2, VWF, F8
21dextran sulfate459.0IL6, F5, JAK2, APOH
22cyclosporin a45 29 6010.9F2, JAK2, F8
2311-dehydrothromboxane b2458.9VWF, F2, SERPINE1, APOH
24aprotinin45 119.9SERPINC1, F5, VWF, PLAT, SERPINE1
25vitamin b12458.9F5, APOH, G6PD, MTHFR, VWF
26tirofiban45 119.9SERPINC1, PLAT, F2, VWF
27dermatan sulfate458.8F2, SERPINC1, VWF, F5, PLAT
28cyclophosphamide45 50 1110.8F5, APOH, F8, G6PD, MTHFR, VWF
29perindopril45 50 1110.8VWF, SERPINE1, PLAT, VEGFA
30ristocetin458.6F2, VWF, F5, PLAT, SERPINC1, F8
31folate458.6MTHFR, F5, G6PD, APOH, SERPINC1, VWF
32citrate458.4SERPINC1, F2, VWF, F5, G6PD, F8
33dexamethasone45 50 29 1111.4VEGFA, SERPINF1, IL6, F8
34ascorbic acid45 249.3JAK2, PLAT, MTHFR, F5, G6PD, SERPINC1
35tranexamic acid45 119.3F2, VWF, F8, SERPINC1, SERPINE1, PLAT
36protamine458.2SERPINE1, SERPINC1, F5, PLAT, F2, IL6
37kininogen458.2SERPINC1, SERPINE1, F2, VWF, F5, PLAT
38desmopressin45 60 29 1111.1F2, VWF, F5, F8, PLAT, SERPINE1
39hirudin458.1SERPINC1, SERPINE1, PLAT, F2, VWF, F5
40atorvastatin45 50 29 11 2412.0PLAT, VWF, IL6, VEGFA, F5, SERPINE1
41endotoxin458.0APOH, JAK2, F5, IL6, SERPINE1, F8
42prostacyclin458.0PLAT, F8, SERPINC1, SERPINE1, APOH, VWF
43simvastatin45 50 60 29 11 2412.6IL6, F2, F5, PLAT, VEGFA, SERPINE1
44epinephrine45 11 249.6VWF, JAK2, F5, G6PD, F8, F2
45homocysteine45 248.6APOH, F5, MTHFR, VWF, F8, F2
46n acetylcysteine457.1G6PD, JAK2, VEGFA, IL6, VWF, SERPINF1
47cholesterol45 29 11 2410.1F8, APOH, IL6, SERPINE1, MTHFR, F5
48aspirin45 50 29 249.8SERPINC1, SERPINE1, APOH, F8, G6PD, JAK2
49fibrinogen456.7SERPINC1, SERPINE1, PLAT, F2, VWF, MTHFR
50vegf456.5APOH, SERPINC1, SERPINE1, VWF, VEGFA, JAK2

GO Terms for genes affiliated with Central Retinal Vein Occlusion

Sources:
16Gene Ontology
See all sources

Cellular components related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.3F8, F5, VEGFA, VWF, SERPINE1
2extracellular matrixGO:0310128.3VWF, PLAT, SERPINE1, SERPINF1, APOH
3extracellular spaceGO:0056156.4SERPINF1, APOH, F8, F5, VEGFA, IL6
4extracellular regionGO:0055765.7F8, F5, VEGFA, IL6, VWF, F2

Biological processes related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.1PLAT, APOH
2negative regulation of proteolysisGO:0458619.8PLAT, F2
3negative regulation of blood coagulationGO:0301959.6APOH, SERPINE1
4negative regulation of fibrinolysisGO:0519189.5SERPINE1, F2, APOH
5positive regulation of blood coagulationGO:0301949.5APOH, F2, SERPINE1
6fibrinolysisGO:0427309.5SERPINE1, PLAT, F2
7positive regulation of protein import into nucleus, translocationGO:0331609.3IL6, JAK2
8negative regulation of endopeptidase activityGO:0109519.3SERPINF1, SERPINC1, SERPINE1
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1JAK2, VEGFA, IL6
10blood coagulation, intrinsic pathwayGO:0075979.1F2, VWF, F8, APOH
11acute-phase responseGO:0069539.0F8, IL6, F2
12regulation of cell shapeGO:0083608.9F2, IL6, VEGFA
13platelet degranulationGO:0025768.7F8, F5, VEGFA, VWF, SERPINE1
14positive regulation of cell proliferationGO:0082848.2F2, IL6, VEGFA, JAK2
15platelet activationGO:0301687.4F8, F5, VEGFA, IL6, VWF, F2
16blood coagulationGO:0075967.2SERPINC1, F8, JAK2, F5, VEGFA, VWF

Molecular functions related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.6SERPINC1, VEGFA, APOH
2protease bindingGO:0020208.9VWF, SERPINE1, SERPINC1
3serine-type endopeptidase inhibitor activityGO:0048678.8SERPINF1, SERPINC1, SERPINE1
4protein bindingGO:0055156.4SERPINC1, APOH, F8, G6PD, JAK2, F5

Products for genes affiliated with Central Retinal Vein Occlusion

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Retinal Vein Occlusion

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet