MCID: CNT016
MIFTS: 49

Central Retinal Vein Occlusion malady

Rare diseases, Cardiovascular diseases categories

Aliases & Classifications for Central Retinal Vein Occlusion

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Central Retinal Vein Occlusion, Aliases & Descriptions:

Name: Central Retinal Vein Occlusion 9 11 43 47 60
 
Crvo 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:2450
ICD9CM27 362.35
SNOMED-CT55 68478007, 193378003
Orphanet47 411527

Summaries for Central Retinal Vein Occlusion

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Wikipedia:63 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards based summary: Central Retinal Vein Occlusion, also known as crvo, is related to retinal vein occlusion and retinal artery occlusion. An important gene associated with Central Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Glypican 1 network and Immune response Oncostatin M signaling via JAK Stat in human cells. The compounds fondaparinux and kaolin have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are vision/eye and respiratory system.

Related Diseases for Central Retinal Vein Occlusion

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Diseases in the Retinal Vein Occlusion family:

central retinal vein occlusion

Diseases related to Central Retinal Vein Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vein occlusion32.6VEGFA, APOH, SERPINC1, MTHFR, F5
2retinal artery occlusion31.8APOH
3branch retinal artery occlusion31.6F5
4macular holes31.6SERPINF1
5purpura31.6SERPINC1
6central retinal artery occlusion31.5PLAT
7retinal detachment31.4SERPINF1, VEGFA, PLAT
8retinal vascular occlusion31.1APOH, F5
9nonarteritic anterior ischemic optic neuropathy31.1MTHFR, F5
10sneddon syndrome31.0APOH, SERPINC1
11eclampsia31.0SERPINC1, MTHFR
12hemophilia b30.9F8, F2
13vasculitis30.8F2, APOH, VWF
14lupus erythematosus30.8F2, APOH, SERPINC1, F5
15von willebrand's disease30.3F8, VWF, F2
16factor xii deficiency30.3F5, SERPINC1, APOH, VWF
17leukemia30.3JAK2, MTHFR, IL6, SERPINF1, F8
18essential thrombocythemia30.3JAK2, G6PD, VWF
19protein s deficiency30.2F2, APOH, SERPINE1, F5, F8, MTHFR
20rheumatoid arthritis30.2VEGFA, APOH, JAK2, MTHFR, IL6
21inflammatory bowel disease30.1JAK2, IL6, F5
22systemic lupus erythematosus30.1F2, F8, VWF, APOH, IL6
23protein c deficiency30.0APOH, F2, SERPINE1, SERPINC1, F5, MTHFR
24deficiency anemia29.9VWF, G6PD, JAK2, IL6, F2
25thrombocytosis29.9JAK2, SERPINC1, VWF, F2, IL6
26hyperhomocysteinemia29.8F5, PLAT, F8, MTHFR, SERPINC1, SERPINE1
27hellp syndrome29.8F5, MTHFR, SERPINC1, SERPINE1, APOH, VWF
28thrombophilia29.5F5, PLAT, F8, MTHFR, SERPINC1, SERPINE1
29vascular disease29.4IL6, F8, JAK2, SERPINC1, VEGFA, VWF
30retinitis11.7
31endotheliitis10.9
32chorioretinitis10.9
33neovascular glaucoma10.8
34choroiditis10.7
35neuropathy10.6
36thrombotic thrombocytopenic purpura10.6
37factor xiii deficiency10.5F5
38ischemic optic neuropathy10.5
39retinal vasculitis10.5
40tuberculosis10.5
41cytomegalovirus retinitis10.5
42pyruvate kinase deficiency10.5G6PD
43mediterranean spotted fever10.5G6PD
44patent foramen ovale10.5F5
45diabetic cataract10.5G6PD
46exudative vitreoretinopathy 110.5VEGFA
47homocysteinemia10.5MTHFR, F5
48mondor disease10.4APOH, F5
49intracranial thrombosis10.4PLAT, F5
50multiple myeloma10.4

Graphical network of the top 20 diseases related to Central Retinal Vein Occlusion:



Diseases related to central retinal vein occlusion

Symptoms for Central Retinal Vein Occlusion

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Drugs & Therapeutics for Central Retinal Vein Occlusion

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Drug clinical trials:

Search ClinicalTrials for Central Retinal Vein Occlusion

Search NIH Clinical Center for Central Retinal Vein Occlusion

Genetic Tests for Central Retinal Vein Occlusion

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Anatomical Context for Central Retinal Vein Occlusion

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MalaCards organs/tissues related to Central Retinal Vein Occlusion:

31
Retina, Eye, Endothelial, Myeloid, Colon, Liver, Skin

Animal Models for Central Retinal Vein Occlusion or affiliated genes

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Publications for Central Retinal Vein Occlusion

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Articles related to Central Retinal Vein Occlusion:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Flicker electroretinograms before and after intravitreal ranibizumab injection in eyes with central retinal vein occlusion. (25597703)
2015
2
Presentation of acute central retinal vein occlusion in scleroderma. (25892936)
2015
3
Dermatomyositis-Related Nonischemic Central Retinal Vein Occlusion. (25815857)
2015
4
The effect of antivascular endothelial growth factor therapy on the development of neovascular glaucoma after central retinal vein occlusion: a retrospective analysis. (24800060)
2014
5
Central retinal vein occlusion as a presenting feature in a young patient with protein S deficiency. (25331213)
2014
6
Vitrectomy and panretinal photocoagulation reduces the occurrence of neovascular glaucoma in central retinal vein occlusion with vitreous hemorrhage. (23114407)
2013
7
Three intravitreal bevacizumab versus two intravitreal triamcinolone injections in recent onset central retinal vein occlusion. (24373344)
2013
8
PENTRAXIN 3 AND OTHER INFLAMMATORY FACTORS IN CENTRAL RETINAL VEIN OCCLUSION AND MACULAR EDEMA. (23842103)
2013
9
Comparison of the effects of intravitreal bevacizumab and triamcinolone acetonide in the treatment of macular edema secondary to central retinal vein occlusion. (23571251)
2013
10
Macular infarction following intravitreal bevacizumab for treatment of central retinal vein occlusion. (22823029)
2012
11
Intravitreous bevacizumab treatment for macular edema due to central retinal vein occlusion. (22668313)
2012
12
Longer-term outcomes of a prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. (21317833)
2011
13
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (21275514)
2011
14
Correlation between spectral domain optical coherence tomography findings and visual outcomes in central retinal vein occlusion. (21468337)
2011
15
Predictors of short-term visual outcome after anti-VEGF therapy of macular edema due to central retinal vein occlusion. (21087958)
2011
16
Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study. (21552499)
2011
17
Prospective study of intravitreal triamcinolone acetonide versus bevacizumab for macular edema secondary to central retinal vein occlusion. (21293319)
2011
18
Optic disc area and diameter of the central retinal vein occlusion fellow eyes, determined by optical coherence tomography. (21717883)
2011
19
Cilioretinal artery occlusion combined with central retinal vein occlusion - a report of two cases and review of the literature. (20408080)
2010
20
Central retinal vein occlusion following trabeculectomy with OloGen in patients with advanced glaucoma: a possible side-effect? (20003111)
2010
21
Citalopram-associated central retinal vein occlusion. (18545940)
2009
22
Bilateral simultaneous central retinal vein occlusion secondary to hyperviscosity in Waldenstrom's macroglobulinaemia. (18600248)
2008
23
Crohn's disease complicated by granulomatous interstitial nephritis, choroidal neovascularization, and central retinal vein occlusion. (18195499)
2008
24
Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion. (18759522)
2008
25
The JAK2 V617F mutation is not a cause of central retinal vein occlusion. (18766271)
2008
26
Malnutrition and bilateral central retinal vein occlusion in a young woman: a case report. (18331629)
2008
27
Central retinal vein occlusion as a possible presenting manifestation of Sneddon syndrome. (17895826)
2007
28
Clinical case report: treatment of a central retinal vein occlusion with hyperbaric oxygen. (18019081)
2007
29
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
30
Retinal blood flow and macular edema after radial optic neurotomy for central retinal vein occlusion. (17011887)
2006
31
One-year safety and efficacy of intravitreal triamcinolone acetonide for the management of macular edema secondary to central retinal vein occlusion. (17031288)
2006
32
Laser chorioretinal venous anastomosis for progressive nonischemic central retinal vein occlusion. (16515021)
2005
33
Central retinal vein occlusion secondary to an intraocular nematode. (15883297)
2005
34
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
35
Characteristics of visual field defects by scanning laser ophthalmoscope microperimetry after radial optic neurotomy for central retinal vein occlusion. (16141857)
2005
36
Retinal endovascular surgery for central retinal vein occlusion: initial experience of four surgeons. (16077361)
2005
37
Vitrectomy with complete posterior hyaloid removal for ischemic central retinal vein occlusion: series of cases. (15943889)
2005
38
Central retinal vein occlusion associated with liquorice ingestion. (15180854)
2004
39
Exudative retinal detachment following central retinal vein occlusion. (14762434)
2004
40
The question of radial optic neurotomy in central retinal vein occlusion. (15477488)
2004
41
Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. (14707827)
2003
42
Vision-related quality of life in people with central retinal vein occlusion using the 25-item National Eye Institute Visual Function Questionnaire. (12963613)
2003
43
Central retinal vein occlusion in bird-shot retinochoroidopathy. (12096977)
2002
44
Lamina puncture: pars plana optic disc surgery for central retinal vein occlusion. (11934325)
2002
45
Intravitreal injection of tissue plasminogen activator for central retinal vein occlusion. (11797310)
2001
46
Activated protein C resistance in patients with central retinal vein occlusion. (9486021)
1997
47
Thrombolytic therapy for central retinal vein occlusion: results of a pilot study. (8981710)
1996
48
Primary empty sella syndrome and central retinal vein occlusion. (7746642)
1995
49
Prognosis for rubeosis iridis following central retinal vein occlusion. (508688)
1979
50
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978

Variations for Central Retinal Vein Occlusion

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Expression for genes affiliated with Central Retinal Vein Occlusion

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Search GEO for disease gene expression data for Central Retinal Vein Occlusion.

Pathways for genes affiliated with Central Retinal Vein Occlusion

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Pathways related to Central Retinal Vein Occlusion according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SERPINC1, VEGFA
29.7JAK2, VEGFA
3
Show member pathways
9.7JAK2, VEGFA
49.6PLAT, SERPINE1
59.0SERPINE1, IL6, PLAT
69.0IL6, SERPINE1, VEGFA
7
Show member pathways
9.0F2, SERPINC1, F8, F5
8
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.0IL6, JAK2, F2
9
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
8.7VEGFA, SERPINE1, JAK2, PLAT
10
Show member pathways
8.4IL6, JAK2, SERPINF1, VEGFA, F2
11
Show member pathways
thioredoxin pathway36
8.3F2, SERPINE1, MTHFR, IL6, PLAT
128.3VWF, VEGFA, JAK2, IL6
13
Show member pathways
8.1F5, F8, SERPINE1, VEGFA, VWF
14
Show member pathways
7.5F2, VWF, VEGFA, SERPINE1, JAK2, PLAT
15
Show member pathways
7.3F5, F2, VWF, SERPINE1, SERPINC1, F8
16
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
7.3F2, VWF, SERPINE1, SERPINC1, F8, PLAT
17
Show member pathways
6.4F2, VWF, VEGFA, SERPINE1, SERPINC1, JAK2

Compounds for genes affiliated with Central Retinal Vein Occlusion

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Compounds related to Central Retinal Vein Occlusion according to GeneCards Suite gene sharing:

(show top 50)    (show all 228)
idCompoundScoreTop Affiliating Genes
1fondaparinux439.8F5, F2, PLAT
2kaolin439.5F2, F8, F5, APOH
3spectrozyme439.5F5, SERPINC1, PLAT, F2
4bivalirudin43 1210.4F2, SERPINC1, PLAT, F5
5argatroban43 1210.4PLAT, F2, SERPINC1, F5
6gabexate mesilate439.2PLAT, F5, IL6, SERPINC1
7batroxobin439.2F5, PLAT, F2, SERPINE1
8protamine sulfate439.2F5, PLAT, F2, SERPINC1
9ancrod438.9F2, SERPINE1, SERPINC1, PLAT, F5
10dextran sulfate438.8F5, IL6, JAK2, SERPINC1, APOH
11ppack438.7VWF, F2, SERPINC1, PLAT
12hydroxyethyl starch438.7F2, F8, SERPINC1, VWF
1311-dehydrothromboxane b2438.6F2, APOH, VWF, SERPINE1
14dermatan sulfate438.6VWF, F5, PLAT, SERPINC1, F2
15vitamin b12438.5VWF, APOH, G6PD, F5, MTHFR
16tirofiban43 129.5F2, VWF, SERPINC1, PLAT
17folate438.3VWF, APOH, SERPINC1, G6PD, MTHFR, F5
18protamine438.3F5, IL6, SERPINC1, PLAT, SERPINE1, F2
19ristocetin438.3SERPINC1, F5, F8, VWF, F2, PLAT
20endotoxin438.2F5, IL6, JAK2, APOH, SERPINE1, F8
21citrate438.2F5, VWF, SERPINC1, G6PD, F8, F2
22phosphatidylserine43 28 1210.0F2, G6PD, F5, F8, VWF, APOH
23atorvastatin43 49 28 24 1212.0PLAT, VEGFA, SERPINE1, IL6, F5, VWF
24tranexamic acid43 129.0F8, PLAT, F2, SERPINC1, VWF, SERPINE1
25ascorbic acid43 248.9SERPINC1, G6PD, VWF, MTHFR, F5, PLAT
26kininogen437.8VWF, SERPINE1, APOH, F2, SERPINC1, F5
27warfarin43 49 24 1210.8F5, PLAT, F8, MTHFR, SERPINC1, APOH
28desmopressin43 59 28 1210.7F5, PLAT, F8, F2, VWF, SERPINE1
29hirudin437.7F5, PLAT, F8, SERPINC1, SERPINE1, VWF
30pge1437.7SERPINE1, APOH, VWF, F2, IL6, PLAT
31cyclophosphamide43 49 129.7VWF, F5, VEGFA, APOH, SERPINE1, G6PD
32simvastatin43 49 59 28 24 1212.6VEGFA, PLAT, IL6, SERPINE1, VWF, F2
33prostacyclin437.6SERPINC1, APOH, SERPINE1, F8, VEGFA, VWF
34epinephrine43 24 129.6F2, VWF, G6PD, JAK2, IL6, F8
35aprotinin43 128.5SERPINC1, SERPINE1, VWF, F2, IL6, PLAT
36lactate437.4F2, VWF, APOH, G6PD, F5, F8
37cyclosporin a43 28 599.3VWF, JAK2, MTHFR, IL6, F2, F8
38homocysteine43 248.2F2, VWF, APOH, SERPINE1, SERPINC1, MTHFR
39n acetylcysteine437.2SERPINC1, IL6, SERPINF1, VEGFA, VWF, G6PD
40cholesterol43 28 24 129.9PLAT, APOH, IL6, MTHFR, VWF, SERPINE1
41aspartate436.9F2, VWF, F5, SERPINE1, G6PD, JAK2
42dexamethasone43 49 28 129.8VWF, F8, VEGFA, IL6, JAK2, SERPINE1
43fibrinogen436.7VWF, F2, APOH, F5, PLAT, SERPINE1
44heparin43 28 24 129.6F2, F5, VWF, F8, PLAT, MTHFR
45nitric oxide43 24 128.5F5, VWF, SERPINF1, SERPINE1, JAK2, IL6
46vegf436.5SERPINC1, F5, JAK2, IL6, F8, SERPINE1
47aspirin43 49 28 249.3F8, VWF, F2, APOH, SERPINE1, F5
48creatinine436.3F2, F8, F5, PLAT, IL6, MTHFR
49serine436.2SERPINC1, SERPINE1, F8, VWF, G6PD, JAK2
50estrogen435.8APOH, VEGFA, VWF, F2, SERPINE1, SERPINC1

GO Terms for genes affiliated with Central Retinal Vein Occlusion

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Cellular components related to Central Retinal Vein Occlusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.2PLAT, SERPINE1, SERPINF1, APOH, VWF
2platelet alpha granule lumenGO:00310937.8VWF, VEGFA, SERPINE1, F8, F5
3extracellular spaceGO:00056156.7F5, F2, VEGFA, APOH, SERPINF1, SERPINE1
4extracellular regionGO:00055766.0F2, VWF, VEGFA, SERPINF1, SERPINE1, SERPINC1

Biological processes related to Central Retinal Vein Occlusion according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:003163910.2APOH, PLAT
2negative regulation of proteolysisGO:00458619.9PLAT, F2
3negative regulation of blood coagulationGO:00301959.8APOH, SERPINE1
4response to hypoxiaGO:00016669.8VEGFA, MTHFR, PLAT
5platelet-derived growth factor receptor signaling pathwayGO:00480089.7JAK2, PLAT
6positive regulation of protein import into nucleus, translocationGO:00331609.7IL6, JAK2
7response to glucocorticoidGO:00513849.6PLAT, IL6, SERPINF1
8mesoderm developmentGO:00074989.6JAK2, VEGFA
9negative regulation of fibrinolysisGO:00519189.5SERPINE1, APOH, F2
10positive regulation of blood coagulationGO:00301949.5F2, APOH, SERPINE1
11regulation of cell shapeGO:00083609.5F2, VEGFA, IL6
12defense response to Gram-negative bacteriumGO:00508299.4IL6, SERPINE1
13acute-phase responseGO:00069539.4F8, IL6, F2
14fibrinolysisGO:00427309.4PLAT, SERPINE1, F2
15positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4VEGFA, JAK2, IL6
16positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.4JAK2, IL6
17response to antibioticGO:00466779.4IL6, JAK2
18negative regulation of endopeptidase activityGO:00109519.4SERPINC1, SERPINE1, SERPINF1
19positive regulation of nitric oxide biosynthetic processGO:00454299.1IL6, JAK2
20blood coagulation, intrinsic pathwayGO:00075978.9F2, VWF, APOH, F8
21positive regulation of cell proliferationGO:00082848.9IL6, JAK2, VEGFA, F2
22platelet degranulationGO:00025768.5VWF, VEGFA, SERPINE1, F8, F5
23platelet activationGO:00301687.5F2, VWF, VEGFA, SERPINE1, IL6, F8
24blood coagulationGO:00075966.8F5, F2, VWF, VEGFA, SERPINE1, SERPINC1

Molecular functions related to Central Retinal Vein Occlusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.2SERPINC1, APOH, VEGFA
2growth factor activityGO:00080839.2IL6, VEGFA, F2
3serine-type endopeptidase activityGO:00042529.2F2, F8, PLAT, F5
4serine-type endopeptidase inhibitor activityGO:00048679.0SERPINF1, SERPINE1, SERPINC1
5protease bindingGO:00020208.6SERPINC1, SERPINE1, VWF
6protein bindingGO:00055155.4F5, F2, VWF, VEGFA, APOH, SERPINE1

Products for genes affiliated with Central Retinal Vein Occlusion

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Sources for Central Retinal Vein Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet