MCID: CNT016
MIFTS: 55

Central Retinal Vein Occlusion malady

Cardiovascular diseases category

Summaries for Central Retinal Vein Occlusion

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66Wikipedia, 34MalaCards
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Wikipedia:66 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards: Central Retinal Vein Occlusion is related to retinal vein occlusion and macular holes. An important gene associated with Central Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Glypican 1 network and Immune response Oncostatin M signaling via JAK Stat in human cells. The compounds fondaparinux and kaolin have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are vision/eye and respiratory system.

Aliases & Classifications for Central Retinal Vein Occlusion

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

central retinal vein occlusion 9 11 46 63


External Ids:

Disease Ontology9 DOID:2450
SNOMED-CT59 68478007, 193378003
ICD9CM28 362.35

Related Diseases for Central Retinal Vein Occlusion

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Retinal Vein Occlusion family:

central retinal vein occlusion

Diseases related to Central Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 192)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vein occlusion32.4VEGFA, APOH, SERPINC1, MTHFR, F5
2macular holes31.1SERPINF1
3retinal detachment31.1SERPINF1, VEGFA, PLAT
4retinal artery occlusion31.1APOH
5purpura30.9SERPINC1
6hyperhomocysteinemia30.9F5, PLAT, F8, MTHFR, SERPINC1, SERPINE1
7hypertension30.9PLAT, MTHFR, F5, SERPINE1, F2
8branch retinal artery occlusion30.8F5
9central retinal artery occlusion30.8PLAT
10protein s deficiency30.8F5, SERPINC1
11vasculitis30.7F2, APOH, VWF
12lupus erythematosus30.6F2, APOH, SERPINC1, F5
13leukemia30.6JAK2, MTHFR, IL6, SERPINF1, F8
14factor xii deficiency30.6F5
15retinal vascular occlusion30.6APOH, F5
16sneddon syndrome30.5APOH, SERPINC1
17eclampsia30.5SERPINC1, MTHFR
18thrombophilia30.5F5, PLAT, F8, MTHFR, SERPINC1, SERPINE1
19hemophilia b30.5F8, F2
20systemic lupus erythematosus30.5F2, F8, VWF, APOH, IL6
21deficiency anemia30.4VWF, G6PD, JAK2, IL6, F2
22diabetic retinopathy30.4VEGFA, SERPINE1, SERPINF1
23antithrombin iii deficiency30.4F5, F2, APOH, SERPINC1, MTHFR
24von willebrand's disease30.4F8, VWF, F2
25inflammatory bowel disease30.3JAK2, IL6, F5
26rheumatoid arthritis30.3VEGFA, APOH, JAK2, MTHFR, IL6
27protein c deficiency30.3APOH, F2, SERPINE1, SERPINC1, F5, MTHFR
28hellp syndrome30.2F5, MTHFR, SERPINC1, SERPINE1, APOH, VWF
29thrombocytosis30.2JAK2, SERPINC1, VWF, F2, IL6
30vascular disease30.1IL6, F8, JAK2, SERPINC1, VEGFA, VWF
31pre-eclampsia29.9F2, VWF, VEGFA, F5, PLAT, F8
32retinitis11.6
33glaucoma10.9
34chorioretinitis10.9
35endotheliitis10.8
36neovascular glaucoma10.7
37cystoid macular edema10.7
38choroiditis10.7
39neuropathy10.6
40thrombotic thrombocytopenic purpura10.5
41tuberculosis10.5
42cytomegalovirus retinitis10.5
43hepatitis c10.4
44iron deficiency anemia10.4
45retinal vasculitis10.4
46macroglobulinemia10.4
47rubeosis iridis10.4
48primary pulmonary hypertension10.4
49hepatitis10.4
50multiple myeloma10.4

Graphical network of the top 20 diseases related to Central Retinal Vein Occlusion:



Diseases related to central retinal vein occlusion

Symptoms for Central Retinal Vein Occlusion

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Drugs & Therapeutics for Central Retinal Vein Occlusion

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Central Retinal Vein Occlusion

Drug clinical trials:

Search ClinicalTrials for Central Retinal Vein Occlusion

Search NIH Clinical Center for Central Retinal Vein Occlusion

Search CenterWatch for Central Retinal Vein Occlusion

Genetic Tests for Central Retinal Vein Occlusion

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Anatomical Context for Central Retinal Vein Occlusion

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34MalaCards
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MalaCards organs/tissues related to Central Retinal Vein Occlusion:

34
Retina, Eye, Endothelial, Myeloid, Skin, Liver, Colon

Animal Models for Central Retinal Vein Occlusion or affiliated genes

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38MGI
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Publications for Central Retinal Vein Occlusion

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53PubMed
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Articles related to Central Retinal Vein Occlusion:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Vitrectomy and panretinal photocoagulation reduces the occurrence of neovascular glaucoma in central retinal vein occlusion with vitreous hemorrhage. (23114407)
2013
2
Three intravitreal bevacizumab versus two intravitreal triamcinolone injections in recent onset central retinal vein occlusion. (24373344)
2013
3
PENTRAXIN 3 AND OTHER INFLAMMATORY FACTORS IN CENTRAL RETINAL VEIN OCCLUSION AND MACULAR EDEMA. (23842103)
2013
4
Comparison of the effects of intravitreal bevacizumab and triamcinolone acetonide in the treatment of macular edema secondary to central retinal vein occlusion. (23571251)
2013
5
Progressive optic nerve collateralization after serial intravitreal ranibizumab injections for central retinal vein occlusion. (23190926)
2013
6
Macular infarction following intravitreal bevacizumab for treatment of central retinal vein occlusion. (22823029)
2012
7
Intravitreous bevacizumab treatment for macular edema due to central retinal vein occlusion. (22668313)
2012
8
Longer-term outcomes of a prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. (21317833)
2011
9
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (21275514)
2011
10
Correlation between spectral domain optical coherence tomography findings and visual outcomes in central retinal vein occlusion. (21468337)
2011
11
Predictors of short-term visual outcome after anti-VEGF therapy of macular edema due to central retinal vein occlusion. (21087958)
2011
12
Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study. (21552499)
2011
13
Prospective study of intravitreal triamcinolone acetonide versus bevacizumab for macular edema secondary to central retinal vein occlusion. (21293319)
2011
14
Optic disc area and diameter of the central retinal vein occlusion fellow eyes, determined by optical coherence tomography. (21717883)
2011
15
Rapid resolution of macular edema associated with central retinal vein occlusion using ranibizumab after failure with multiple bevacizumab injections. (22044337)
2011
16
Cilioretinal artery occlusion combined with central retinal vein occlusion - a report of two cases and review of the literature. (20408080)
2010
17
Central retinal vein occlusion following trabeculectomy with OloGen in patients with advanced glaucoma: a possible side-effect? (20003111)
2010
18
Comparison of two doses of intravitreal bevacizumab as primary treatment for macular edema secondary to central retinal vein occlusion: results of the pan American collaborative retina study group at 24 months. (20616679)
2010
19
Citalopram-associated central retinal vein occlusion. (18545940)
2009
20
Bilateral simultaneous central retinal vein occlusion secondary to hyperviscosity in Waldenstrom's macroglobulinaemia. (18600248)
2008
21
Crohn's disease complicated by granulomatous interstitial nephritis, choroidal neovascularization, and central retinal vein occlusion. (18195499)
2008
22
Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion. (18759522)
2008
23
The JAK2 V617F mutation is not a cause of central retinal vein occlusion. (18766271)
2008
24
Malnutrition and bilateral central retinal vein occlusion in a young woman: a case report. (18331629)
2008
25
Central retinal vein occlusion as a possible presenting manifestation of Sneddon syndrome. (17895826)
2007
26
Clinical case report: treatment of a central retinal vein occlusion with hyperbaric oxygen. (18019081)
2007
27
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
28
Retinal blood flow and macular edema after radial optic neurotomy for central retinal vein occlusion. (17011887)
2006
29
One-year safety and efficacy of intravitreal triamcinolone acetonide for the management of macular edema secondary to central retinal vein occlusion. (17031288)
2006
30
Laser chorioretinal venous anastomosis for progressive nonischemic central retinal vein occlusion. (16515021)
2005
31
Central retinal vein occlusion secondary to an intraocular nematode. (15883297)
2005
32
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
33
Characteristics of visual field defects by scanning laser ophthalmoscope microperimetry after radial optic neurotomy for central retinal vein occlusion. (16141857)
2005
34
Retinal endovascular surgery for central retinal vein occlusion: initial experience of four surgeons. (16077361)
2005
35
Vitrectomy with complete posterior hyaloid removal for ischemic central retinal vein occlusion: series of cases. (15943889)
2005
36
Central retinal vein occlusion associated with liquorice ingestion. (15180854)
2004
37
Exudative retinal detachment following central retinal vein occlusion. (14762434)
2004
38
The question of radial optic neurotomy in central retinal vein occlusion. (15477488)
2004
39
Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. (14707827)
2003
40
Vision-related quality of life in people with central retinal vein occlusion using the 25-item National Eye Institute Visual Function Questionnaire. (12963613)
2003
41
Central retinal vein occlusion immediately following cardiac surgery. (12757097)
2003
42
Central retinal vein occlusion in bird-shot retinochoroidopathy. (12096977)
2002
43
Lamina puncture: pars plana optic disc surgery for central retinal vein occlusion. (11934325)
2002
44
Recurrent central retinal vein occlusion in a young thrombophilic patient with factor V Leiden mutation. (12022286)
2002
45
Intravitreal injection of tissue plasminogen activator for central retinal vein occlusion. (11797310)
2001
46
Activated protein C resistance in patients with central retinal vein occlusion. (9486021)
1997
47
Thrombolytic therapy for central retinal vein occlusion: results of a pilot study. (8981710)
1996
48
Primary empty sella syndrome and central retinal vein occlusion. (7746642)
1995
49
Prognosis for rubeosis iridis following central retinal vein occlusion. (508688)
1979
50
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978

Variations for Central Retinal Vein Occlusion

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Expression for genes affiliated with Central Retinal Vein Occlusion

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Retinal Vein Occlusion

Search GEO for disease gene expression data for Central Retinal Vein Occlusion.

Pathways for genes affiliated with Central Retinal Vein Occlusion

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 31KEGG, 54QIAGEN, 55R&D Systems
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Pathways related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8VEGFA, SERPINC1
29.7VEGFA, JAK2
3
Show member pathways
9.7JAK2, VEGFA
49.6SERPINE1, PLAT
59.0PLAT, IL6, SERPINE1
69.0SERPINE1, IL6, VEGFA
7
Show member pathways
9.0F8, F5, SERPINC1, F2
8
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.0IL6, JAK2, F2
9
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
8.7JAK2, PLAT, VEGFA, SERPINE1
10
Show member pathways
8.4IL6, JAK2, VEGFA, F2, SERPINF1
11
Show member pathways
thioredoxin pathway39
8.3SERPINE1, MTHFR, F2, IL6, PLAT
128.3JAK2, VEGFA, IL6, VWF
13
Show member pathways
8.1SERPINE1, VWF, F5, F8, VEGFA
14
Show member pathways
7.5JAK2, VWF, F2, PLAT, VEGFA, SERPINE1
15
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
7.3F2, VWF, SERPINE1, F5, SERPINC1, PLAT
16
Show member pathways
7.3VWF, F2, SERPINE1, SERPINC1, F8, PLAT
17
Show member pathways
6.4F2, VEGFA, SERPINE1, SERPINC1, VWF, F5

Compounds for genes affiliated with Central Retinal Vein Occlusion

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 228)
idCompoundScoreTop Affiliating Genes
1fondaparinux469.8F5, F2, PLAT
2kaolin469.5F2, F8, F5, APOH
3spectrozyme469.5F5, SERPINC1, PLAT, F2
4bivalirudin46 1210.4F2, SERPINC1, PLAT, F5
5argatroban46 1210.4PLAT, F2, SERPINC1, F5
6gabexate mesilate469.2PLAT, F5, IL6, SERPINC1
7batroxobin469.2F5, PLAT, F2, SERPINE1
8protamine sulfate469.2F5, PLAT, F2, SERPINC1
9ancrod468.9F2, SERPINE1, SERPINC1, PLAT, F5
10dextran sulfate468.8F5, IL6, JAK2, SERPINC1, APOH
11ppack468.7VWF, F2, SERPINC1, PLAT
12hydroxyethyl starch468.7F2, F8, SERPINC1, VWF
1311-dehydrothromboxane b2468.6F2, APOH, VWF, SERPINE1
14dermatan sulfate468.6VWF, F5, PLAT, SERPINC1, F2
15vitamin b12468.5VWF, APOH, G6PD, F5, MTHFR
16tirofiban46 129.5F2, VWF, SERPINC1, PLAT
17folate468.3VWF, APOH, SERPINC1, G6PD, MTHFR, F5
18protamine468.3F5, IL6, SERPINC1, PLAT, SERPINE1, F2
19ristocetin468.3SERPINC1, F5, F8, VWF, F2, PLAT
20endotoxin468.2F5, IL6, JAK2, APOH, SERPINE1, F8
21citrate468.2F5, VWF, SERPINC1, G6PD, F8, F2
22phosphatidylserine46 30 1210.0F2, G6PD, F5, F8, VWF, APOH
23atorvastatin46 52 30 25 1212.0PLAT, VEGFA, SERPINE1, IL6, F5, VWF
24tranexamic acid46 129.0F8, PLAT, F2, SERPINC1, VWF, SERPINE1
25ascorbic acid46 258.9SERPINC1, G6PD, VWF, MTHFR, F5, PLAT
26kininogen467.8VWF, SERPINE1, APOH, F2, SERPINC1, F5
27warfarin46 52 25 1210.8F5, PLAT, F8, MTHFR, SERPINC1, APOH
28desmopressin46 62 30 1210.7F5, PLAT, F8, F2, VWF, SERPINE1
29hirudin467.7F5, PLAT, F8, SERPINC1, SERPINE1, VWF
30pge1467.7SERPINE1, APOH, VWF, F2, IL6, PLAT
31cyclophosphamide46 52 129.7VWF, F5, VEGFA, APOH, SERPINE1, G6PD
32simvastatin46 52 62 30 25 1212.6VEGFA, PLAT, IL6, SERPINE1, VWF, F2
33prostacyclin467.6SERPINC1, APOH, SERPINE1, F8, VEGFA, VWF
34epinephrine46 25 129.6F2, VWF, G6PD, JAK2, IL6, F8
35aprotinin46 128.5SERPINC1, SERPINE1, VWF, F2, IL6, PLAT
36lactate467.4F2, VWF, APOH, G6PD, F5, F8
37cyclosporin a46 30 629.3VWF, JAK2, MTHFR, IL6, F2, F8
38homocysteine46 258.2F2, VWF, APOH, SERPINE1, SERPINC1, MTHFR
39n acetylcysteine467.2SERPINC1, IL6, SERPINF1, VEGFA, VWF, G6PD
40cholesterol46 30 25 129.9PLAT, APOH, IL6, MTHFR, VWF, SERPINE1
41aspartate466.9F2, VWF, F5, SERPINE1, G6PD, JAK2
42dexamethasone46 52 30 129.8VWF, F8, VEGFA, IL6, JAK2, SERPINE1
43fibrinogen466.7VWF, F2, APOH, F5, PLAT, SERPINE1
44heparin46 30 25 129.6F2, F5, VWF, F8, PLAT, MTHFR
45nitric oxide46 25 128.5F5, VWF, SERPINF1, SERPINE1, JAK2, IL6
46vegf466.5SERPINC1, F5, JAK2, IL6, F8, SERPINE1
47aspirin46 52 30 259.3F8, VWF, F2, APOH, SERPINE1, F5
48creatinine466.3F2, F8, F5, PLAT, IL6, MTHFR
49serine466.2SERPINC1, SERPINE1, F8, VWF, G6PD, JAK2
50estrogen465.8APOH, VEGFA, VWF, F2, SERPINE1, SERPINC1

GO Terms for genes affiliated with Central Retinal Vein Occlusion

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17Gene Ontology
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Cellular components related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.2VWF, APOH, SERPINF1, SERPINE1, PLAT
2platelet alpha granule lumenGO:0310937.8VEGFA, SERPINE1, F8, F5, VWF
3extracellular spaceGO:0056156.7SERPINE1, PLAT, F8, IL6, SERPINC1, F5
4extracellular regionGO:0055766.0F5, F2, PLAT, F8, IL6, SERPINC1

Biological processes related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.2PLAT, APOH
2negative regulation of proteolysisGO:0458619.9PLAT, F2
3negative regulation of blood coagulationGO:0301959.8APOH, SERPINE1
4response to hypoxiaGO:0016669.8VEGFA, MTHFR, PLAT
5platelet-derived growth factor receptor signaling pathwayGO:0480089.7PLAT, JAK2
6positive regulation of protein import into nucleus, translocationGO:0331609.7JAK2, IL6
7response to glucocorticoidGO:0513849.6IL6, PLAT, SERPINF1
8mesoderm developmentGO:0074989.6JAK2, VEGFA
9positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.5IL6, JAK2
10negative regulation of fibrinolysisGO:0519189.5SERPINE1, APOH, F2
11positive regulation of blood coagulationGO:0301949.5SERPINE1, F2, APOH
12regulation of cell shapeGO:0083609.5F2, VEGFA, IL6
13defense response to Gram-negative bacteriumGO:0508299.4SERPINE1, IL6
14acute-phase responseGO:0069539.4F8, F2, IL6
15fibrinolysisGO:0427309.4F2, PLAT, SERPINE1
16positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4IL6, VEGFA, JAK2
17response to antibioticGO:0466779.4IL6, JAK2
18negative regulation of endopeptidase activityGO:0109519.4SERPINC1, SERPINE1, SERPINF1
19positive regulation of nitric oxide biosynthetic processGO:0454299.1JAK2, IL6
20blood coagulation, intrinsic pathwayGO:0075978.9F2, VWF, APOH, F8
21positive regulation of cell proliferationGO:0082848.9F2, IL6, JAK2, VEGFA
22platelet degranulationGO:0025768.5VEGFA, VWF, F5, F8, SERPINE1
23platelet activationGO:0301687.5SERPINE1, IL6, F2, VWF, VEGFA, F5
24blood coagulationGO:0075966.8SERPINE1, F2, VWF, VEGFA, SERPINC1, JAK2

Molecular functions related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.2APOH, SERPINC1, VEGFA
2growth factor activityGO:0080839.2F2, VEGFA, IL6
3serine-type endopeptidase activityGO:0042529.2F2, F8, PLAT, F5
4serine-type endopeptidase inhibitor activityGO:0048679.0SERPINF1, SERPINE1, SERPINC1
5protease bindingGO:0020208.6SERPINC1, VWF, SERPINE1
6protein bindingGO:0055155.4JAK2, SERPINC1, IL6, F8, PLAT, F5

Products for genes affiliated with Central Retinal Vein Occlusion

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Retinal Vein Occlusion

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet