CRVO
MCID: CNT016
MIFTS: 58

Central Retinal Vein Occlusion (CRVO) malady

Rare diseases, Cardiovascular diseases categories
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Summaries for Central Retinal Vein Occlusion

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Wikipedia:65 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards based summary: Central Retinal Vein Occlusion, also known as CRVO, is related to retinal vein occlusion and retinal artery occlusion. An important gene associated with Central Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Glypican 1 network and Immune response Oncostatin M signaling via JAK Stat in human cells. The compounds fondaparinux and kaolin have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are vision/eye and respiratory system.

Aliases & Classifications for Central Retinal Vein Occlusion

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Central Retinal Vein Occlusion, Aliases & Descriptions:

Name: Central Retinal Vein Occlusion 8 10 44 48 62
 
Crvo 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:2450
SNOMED-CT57 193378003, 68478007
ICD9CM27 362.35

Related Diseases for Central Retinal Vein Occlusion

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Diseases in the Retinal Vein Occlusion family:

central retinal vein occlusion

Diseases related to Central Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vein occlusion32.6VEGFA, APOH, SERPINC1, MTHFR, F5
2retinal artery occlusion31.8APOH
3branch retinal artery occlusion31.6F5
4macular holes31.6SERPINF1
5purpura31.6SERPINC1
6central retinal artery occlusion31.5PLAT
7retinal detachment31.4VEGFA, SERPINF1, PLAT
8factor xii deficiency31.2F5
9retinal vascular occlusion31.1F5, APOH
10sneddon syndrome31.0APOH, SERPINC1
11eclampsia31.0MTHFR, SERPINC1
12hemophilia b30.9F2, F8
13lupus erythematosus30.8F2, APOH, SERPINC1, F5
14hypertension30.7F2, SERPINE1, MTHFR, PLAT, F5
15vasculitis30.7APOH, VWF, F2
16diabetic retinopathy30.6VEGFA, SERPINF1, SERPINE1
17antithrombin iii deficiency30.4F2, APOH, SERPINC1, MTHFR, F5
18von willebrand's disease30.4F2, VWF, F8
19leukemia30.3SERPINF1, JAK2, MTHFR, IL6, F8
20protein s deficiency30.2F2, APOH, SERPINE1, SERPINC1, MTHFR, F8
21rheumatoid arthritis30.2VEGFA, APOH, JAK2, MTHFR, IL6
22inflammatory bowel disease30.1JAK2, IL6, F5
23systemic lupus erythematosus30.1F8, IL6, APOH, VWF, F2
24protein c deficiency30.0F2, APOH, SERPINE1, SERPINC1, MTHFR, F5
25deficiency anemia29.9IL6, JAK2, G6PD, VWF, F2
26thrombocytosis29.9F2, VWF, SERPINC1, JAK2, IL6
27hyperhomocysteinemia29.9SERPINE1, SERPINC1, MTHFR, F8, PLAT, F5
28hellp syndrome29.8VWF, APOH, SERPINE1, SERPINC1, MTHFR, F5
29thrombophilia29.5F2, VWF, APOH, SERPINE1, SERPINC1, MTHFR
30vascular disease29.2F5, PLAT, VWF, VEGFA, APOH, SERPINE1
31pre-eclampsia28.5SERPINC1, MTHFR, IL6, F8, PLAT, F5
32retinitis11.6
33chorioretinitis10.9
34endotheliitis10.9
35neovascular glaucoma10.8
36cystoid macular edema10.8
37choroiditis10.7
38neuropathy10.6
39thrombotic thrombocytopenic purpura10.6
40ischemic optic neuropathy10.5
41tuberculosis10.5
42cytomegalovirus retinitis10.5
43pyruvate kinase deficiency10.5G6PD
44mediterranean spotted fever10.5G6PD
45patent foramen ovale10.5F5
46diabetic cataract10.5G6PD
47retinopathy of prematurity10.5VEGFA
48homocysteinemia10.5F5, MTHFR
49mondor disease10.5F5, APOH
50intracranial thrombosis10.4PLAT, F5

Graphical network of the top 20 diseases related to Central Retinal Vein Occlusion:



Diseases related to central retinal vein occlusion

Symptoms for Central Retinal Vein Occlusion

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Drugs & Therapeutics for Central Retinal Vein Occlusion

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Drug clinical trials:

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Genetic Tests for Central Retinal Vein Occlusion

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Anatomical Context for Central Retinal Vein Occlusion

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MalaCards organs/tissues related to Central Retinal Vein Occlusion:

32
Retina, Eye, Endothelial, Myeloid, Colon, Liver, Skin

Animal Models for Central Retinal Vein Occlusion or affiliated genes

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Publications for Central Retinal Vein Occlusion

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Articles related to Central Retinal Vein Occlusion:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
The effect of antivascular endothelial growth factor therapy on the development of neovascular glaucoma after central retinal vein occlusion: a retrospective analysis. (24800060)
2014
2
Central retinal vein occlusion as a presenting feature in a young patient with protein S deficiency. (25331213)
2014
3
FUNDUS CHANGES IN CENTRAL RETINAL VEIN OCCLUSION. (25084156)
2014
4
Detection of underdiagnosed concurrent branch retinal artery occlusion in a patient with central retinal vein occlusion using spectral domain optical coherence tomography. (25015220)
2014
5
Vitrectomy and panretinal photocoagulation reduces the occurrence of neovascular glaucoma in central retinal vein occlusion with vitreous hemorrhage. (23114407)
2013
6
Three intravitreal bevacizumab versus two intravitreal triamcinolone injections in recent onset central retinal vein occlusion. (24373344)
2013
7
PENTRAXIN 3 AND OTHER INFLAMMATORY FACTORS IN CENTRAL RETINAL VEIN OCCLUSION AND MACULAR EDEMA. (23842103)
2013
8
Comparison of the effects of intravitreal bevacizumab and triamcinolone acetonide in the treatment of macular edema secondary to central retinal vein occlusion. (23571251)
2013
9
Macular infarction following intravitreal bevacizumab for treatment of central retinal vein occlusion. (22823029)
2012
10
Intravitreous bevacizumab treatment for macular edema due to central retinal vein occlusion. (22668313)
2012
11
Longer-term outcomes of a prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. (21317833)
2011
12
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (21275514)
2011
13
Correlation between spectral domain optical coherence tomography findings and visual outcomes in central retinal vein occlusion. (21468337)
2011
14
Predictors of short-term visual outcome after anti-VEGF therapy of macular edema due to central retinal vein occlusion. (21087958)
2011
15
Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study. (21552499)
2011
16
Prospective study of intravitreal triamcinolone acetonide versus bevacizumab for macular edema secondary to central retinal vein occlusion. (21293319)
2011
17
Optic disc area and diameter of the central retinal vein occlusion fellow eyes, determined by optical coherence tomography. (21717883)
2011
18
Rapid resolution of macular edema associated with central retinal vein occlusion using ranibizumab after failure with multiple bevacizumab injections. (22044337)
2011
19
Cilioretinal artery occlusion combined with central retinal vein occlusion - a report of two cases and review of the literature. (20408080)
2010
20
Central retinal vein occlusion following trabeculectomy with OloGen in patients with advanced glaucoma: a possible side-effect? (20003111)
2010
21
Citalopram-associated central retinal vein occlusion. (18545940)
2009
22
Crohn's disease complicated by granulomatous interstitial nephritis, choroidal neovascularization, and central retinal vein occlusion. (18195499)
2008
23
Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion. (18759522)
2008
24
The JAK2 V617F mutation is not a cause of central retinal vein occlusion. (18766271)
2008
25
Malnutrition and bilateral central retinal vein occlusion in a young woman: a case report. (18331629)
2008
26
Central retinal vein occlusion as a possible presenting manifestation of Sneddon syndrome. (17895826)
2007
27
Clinical case report: treatment of a central retinal vein occlusion with hyperbaric oxygen. (18019081)
2007
28
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
29
Retinal blood flow and macular edema after radial optic neurotomy for central retinal vein occlusion. (17011887)
2006
30
One-year safety and efficacy of intravitreal triamcinolone acetonide for the management of macular edema secondary to central retinal vein occlusion. (17031288)
2006
31
Laser chorioretinal venous anastomosis for progressive nonischemic central retinal vein occlusion. (16515021)
2005
32
Central retinal vein occlusion secondary to an intraocular nematode. (15883297)
2005
33
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
34
Characteristics of visual field defects by scanning laser ophthalmoscope microperimetry after radial optic neurotomy for central retinal vein occlusion. (16141857)
2005
35
Retinal endovascular surgery for central retinal vein occlusion: initial experience of four surgeons. (16077361)
2005
36
Vitrectomy with complete posterior hyaloid removal for ischemic central retinal vein occlusion: series of cases. (15943889)
2005
37
Central retinal vein occlusion associated with liquorice ingestion. (15180854)
2004
38
Exudative retinal detachment following central retinal vein occlusion. (14762434)
2004
39
The question of radial optic neurotomy in central retinal vein occlusion. (15477488)
2004
40
Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. (14707827)
2003
41
Vision-related quality of life in people with central retinal vein occlusion using the 25-item National Eye Institute Visual Function Questionnaire. (12963613)
2003
42
Central retinal vein occlusion immediately following cardiac surgery. (12757097)
2003
43
Central retinal vein occlusion in bird-shot retinochoroidopathy. (12096977)
2002
44
Lamina puncture: pars plana optic disc surgery for central retinal vein occlusion. (11934325)
2002
45
Intravitreal injection of tissue plasminogen activator for central retinal vein occlusion. (11797310)
2001
46
Activated protein C resistance in patients with central retinal vein occlusion. (9486021)
1997
47
Thrombolytic therapy for central retinal vein occlusion: results of a pilot study. (8981710)
1996
48
Primary empty sella syndrome and central retinal vein occlusion. (7746642)
1995
49
Prognosis for rubeosis iridis following central retinal vein occlusion. (508688)
1979
50
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978

Variations for Central Retinal Vein Occlusion

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Expression for genes affiliated with Central Retinal Vein Occlusion

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Expression patterns in normal tissues for genes affiliated with Central Retinal Vein Occlusion

Search GEO for disease gene expression data for Central Retinal Vein Occlusion.

Pathways for genes affiliated with Central Retinal Vein Occlusion

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Pathways related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SERPINC1, VEGFA
29.7JAK2, VEGFA
3
Show member pathways
9.7JAK2, VEGFA
49.6PLAT, SERPINE1
59.0SERPINE1, IL6, PLAT
69.0IL6, SERPINE1, VEGFA
7
Show member pathways
9.0F2, SERPINC1, F8, F5
8
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0IL6, JAK2, F2
9
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.7VEGFA, SERPINE1, JAK2, PLAT
10
Show member pathways
8.4IL6, JAK2, SERPINF1, VEGFA, F2
11
Show member pathways
thioredoxin pathway37
8.3F2, SERPINE1, MTHFR, IL6, PLAT
128.3VWF, VEGFA, JAK2, IL6
13
Show member pathways
8.1F5, F8, SERPINE1, VEGFA, VWF
14
Show member pathways
7.5F2, VWF, VEGFA, SERPINE1, JAK2, PLAT
15
Show member pathways
7.3F5, F2, VWF, SERPINE1, SERPINC1, F8
16
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
7.3F2, VWF, SERPINE1, SERPINC1, F8, PLAT
17
Show member pathways
6.4F2, VWF, VEGFA, SERPINE1, SERPINC1, JAK2

Compounds for genes affiliated with Central Retinal Vein Occlusion

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Compounds related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 228)
idCompoundScoreTop Affiliating Genes
1fondaparinux449.8F5, F2, PLAT
2kaolin449.5F2, F8, F5, APOH
3spectrozyme449.5F5, SERPINC1, PLAT, F2
4bivalirudin44 1110.4F2, SERPINC1, PLAT, F5
5argatroban44 1110.4PLAT, F2, SERPINC1, F5
6gabexate mesilate449.2PLAT, F5, IL6, SERPINC1
7batroxobin449.2F5, PLAT, F2, SERPINE1
8protamine sulfate449.2F5, PLAT, F2, SERPINC1
9ancrod448.9F2, SERPINE1, SERPINC1, PLAT, F5
10dextran sulfate448.8F5, IL6, JAK2, SERPINC1, APOH
11ppack448.7VWF, F2, SERPINC1, PLAT
12hydroxyethyl starch448.7F2, F8, SERPINC1, VWF
1311-dehydrothromboxane b2448.6F2, APOH, VWF, SERPINE1
14dermatan sulfate448.6VWF, F5, PLAT, SERPINC1, F2
15vitamin b12448.5VWF, APOH, G6PD, F5, MTHFR
16tirofiban44 119.5F2, VWF, SERPINC1, PLAT
17folate448.3VWF, APOH, SERPINC1, G6PD, MTHFR, F5
18protamine448.3F5, IL6, SERPINC1, PLAT, SERPINE1, F2
19ristocetin448.3SERPINC1, F5, F8, VWF, F2, PLAT
20endotoxin448.2F5, IL6, JAK2, APOH, SERPINE1, F8
21citrate448.2F5, VWF, SERPINC1, G6PD, F8, F2
22phosphatidylserine44 28 1110.0F2, G6PD, F5, F8, VWF, APOH
23atorvastatin44 50 28 24 1112.0PLAT, VEGFA, SERPINE1, IL6, F5, VWF
24tranexamic acid44 119.0F8, PLAT, F2, SERPINC1, VWF, SERPINE1
25ascorbic acid44 248.9SERPINC1, G6PD, VWF, MTHFR, F5, PLAT
26kininogen447.8VWF, SERPINE1, APOH, F2, SERPINC1, F5
27warfarin44 50 24 1110.8F5, PLAT, F8, MTHFR, SERPINC1, APOH
28desmopressin44 61 28 1110.7F5, PLAT, F8, F2, VWF, SERPINE1
29hirudin447.7F5, PLAT, F8, SERPINC1, SERPINE1, VWF
30pge1447.7SERPINE1, APOH, VWF, F2, IL6, PLAT
31cyclophosphamide44 50 119.7VWF, F5, VEGFA, APOH, SERPINE1, G6PD
32simvastatin44 50 61 28 24 1112.6VEGFA, PLAT, IL6, SERPINE1, VWF, F2
33prostacyclin447.6SERPINC1, APOH, SERPINE1, F8, VEGFA, VWF
34epinephrine44 24 119.6F2, VWF, G6PD, JAK2, IL6, F8
35aprotinin44 118.5SERPINC1, SERPINE1, VWF, F2, IL6, PLAT
36lactate447.4F2, VWF, APOH, G6PD, F5, F8
37cyclosporin a44 28 619.3VWF, JAK2, MTHFR, IL6, F2, F8
38homocysteine44 248.2F2, VWF, APOH, SERPINE1, SERPINC1, MTHFR
39n acetylcysteine447.2SERPINC1, IL6, SERPINF1, VEGFA, VWF, G6PD
40cholesterol44 28 24 119.9PLAT, APOH, IL6, MTHFR, VWF, SERPINE1
41aspartate446.9F2, VWF, F5, SERPINE1, G6PD, JAK2
42dexamethasone44 50 28 119.8VWF, F8, VEGFA, IL6, JAK2, SERPINE1
43fibrinogen446.7VWF, F2, APOH, F5, PLAT, SERPINE1
44heparin44 28 24 119.6F2, F5, VWF, F8, PLAT, MTHFR
45nitric oxide44 24 118.5F5, VWF, SERPINF1, SERPINE1, JAK2, IL6
46vegf446.5SERPINC1, F5, JAK2, IL6, F8, SERPINE1
47aspirin44 50 28 249.3F8, VWF, F2, APOH, SERPINE1, F5
48creatinine446.3F2, F8, F5, PLAT, IL6, MTHFR
49serine446.2SERPINC1, SERPINE1, F8, VWF, G6PD, JAK2
50estrogen445.8APOH, VEGFA, VWF, F2, SERPINE1, SERPINC1

GO Terms for genes affiliated with Central Retinal Vein Occlusion

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Cellular components related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.2PLAT, SERPINE1, SERPINF1, APOH, VWF
2platelet alpha granule lumenGO:0310937.8VWF, VEGFA, SERPINE1, F8, F5
3extracellular spaceGO:0056156.7F5, F2, VEGFA, APOH, SERPINF1, SERPINE1
4extracellular regionGO:0055766.0F2, VWF, VEGFA, SERPINF1, SERPINE1, SERPINC1

Biological processes related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.2APOH, PLAT
2negative regulation of proteolysisGO:0458619.9PLAT, F2
3negative regulation of blood coagulationGO:0301959.8APOH, SERPINE1
4response to hypoxiaGO:0016669.8VEGFA, MTHFR, PLAT
5platelet-derived growth factor receptor signaling pathwayGO:0480089.7JAK2, PLAT
6positive regulation of protein import into nucleus, translocationGO:0331609.7IL6, JAK2
7response to glucocorticoidGO:0513849.6PLAT, IL6, SERPINF1
8mesoderm developmentGO:0074989.6JAK2, VEGFA
9negative regulation of fibrinolysisGO:0519189.5SERPINE1, APOH, F2
10positive regulation of blood coagulationGO:0301949.5F2, APOH, SERPINE1
11regulation of cell shapeGO:0083609.5F2, VEGFA, IL6
12defense response to Gram-negative bacteriumGO:0508299.4IL6, SERPINE1
13acute-phase responseGO:0069539.4F8, IL6, F2
14fibrinolysisGO:0427309.4PLAT, SERPINE1, F2
15positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4VEGFA, JAK2, IL6
16positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.4JAK2, IL6
17response to antibioticGO:0466779.4IL6, JAK2
18negative regulation of endopeptidase activityGO:0109519.4SERPINC1, SERPINE1, SERPINF1
19positive regulation of nitric oxide biosynthetic processGO:0454299.1IL6, JAK2
20blood coagulation, intrinsic pathwayGO:0075978.9F2, VWF, APOH, F8
21positive regulation of cell proliferationGO:0082848.9IL6, JAK2, VEGFA, F2
22platelet degranulationGO:0025768.5VWF, VEGFA, SERPINE1, F8, F5
23platelet activationGO:0301687.5F2, VWF, VEGFA, SERPINE1, IL6, F8
24blood coagulationGO:0075966.8F5, F2, VWF, VEGFA, SERPINE1, SERPINC1

Molecular functions related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.2SERPINC1, APOH, VEGFA
2growth factor activityGO:0080839.2IL6, VEGFA, F2
3serine-type endopeptidase activityGO:0042529.2F2, F8, PLAT, F5
4serine-type endopeptidase inhibitor activityGO:0048679.0SERPINF1, SERPINE1, SERPINC1
5protease bindingGO:0020208.6SERPINC1, SERPINE1, VWF
6protein bindingGO:0055155.4F5, F2, VWF, VEGFA, APOH, SERPINE1

Products for genes affiliated with Central Retinal Vein Occlusion

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Sources for Central Retinal Vein Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet