MCID: CNT016
MIFTS: 53

Central Retinal Vein Occlusion malady

Cardiovascular diseases category

Summaries for Central Retinal Vein Occlusion

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63Wikipedia, 32MalaCards
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Wikipedia:63 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards: Central Retinal Vein Occlusion is related to retinal vein occlusion and macular retinal edema. An important gene associated with Central Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Senescence and Autophagy and Dissolution of Fibrin Clot. The compounds estrogen and warfarin have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are cardiovascular system and vision/eye.

Aliases & Classifications for Central Retinal Vein Occlusion

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

central retinal vein occlusion 8 10 44 60


External Ids:

Disease Ontology8 DOID:2450
SNOMED-CT56 193378003, 68478007
ICD9CM27 362.35

Related Diseases for Central Retinal Vein Occlusion

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Retinal Vein Occlusion family:

central retinal vein occlusion

Diseases related to Central Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 249)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vein occlusion32.3APOH, F5, MTHFR, VEGFA, SERPINC1
2macular retinal edema31.8VEGFA, SERPINF1
3retinal artery occlusion31.3APOH
4central retinal artery occlusion31.3PLAT
5retinal vascular occlusion31.3APOH, F5
6glaucoma31.2SERPINF1
7hyperhomocysteinemia31.1MTHFR, VWF, F2, PLAT, SERPINE1, SERPINC1
8retinal detachment31.1SERPINF1, PLAT, VEGFA
9retinal disease30.9F8, VEGFA, VWF, SERPINE1, SERPINF1
10macular holes30.8SERPINF1
11hypertension30.8F5, MTHFR, F2, PLAT, SERPINE1
12branch retinal artery occlusion30.8F5
13purpura30.8SERPINC1
14thrombophilia30.7APOH, F8, F5, MTHFR, VWF, F2
15vasculitis30.7F2, VWF, APOH
16leukemia30.6F8, JAK2, MTHFR, IL6, SERPINF1
17protein s deficiency30.6APOH, F8, F5, MTHFR, F2, SERPINE1
18hemolytic-uremic syndrome30.5VWF
19myeloid leukemia30.5JAK2
20multiple myeloma30.5IL6
21hepatitis30.5F2, F8
22psoriasis30.5IL6
23hepatitis c30.5F8, F2
24factor v deficiency30.5F8, F5, F2
25lupus erythematosus30.5APOH, F5, F2, SERPINC1
26myeloma30.5JAK2, VEGFA, IL6
27deficiency anemia30.5G6PD, JAK2, IL6, VWF, F2
28systemic lupus erythematosus30.5F2, VWF, IL6, F8, APOH
29hemoglobinuria30.3G6PD
30cystic fibrosis30.3F8
31factor xii deficiency30.3F5
32migraine30.3MTHFR, APOH
33sneddon syndrome30.3APOH, SERPINC1
34eclampsia30.3MTHFR, SERPINC1
35acute leukemia30.3MTHFR, JAK2
36inflammatory bowel disease30.3IL6
37pneumonia30.3IL6
38arthritis30.3IL6
39sickle cell disease30.3G6PD, VWF
40hemophilia b30.3F2, F8
41colon cancer30.3VEGFA, MTHFR, JAK2
42retinal vascular disease30.3VEGFA, SERPINF1
43diabetic retinopathy30.3SERPINF1, SERPINE1, VEGFA
44antithrombin iii deficiency30.3SERPINC1, F2, MTHFR, APOH, F5
45von willebrand's disease30.3F2, VWF, F5, F8
46protein c deficiency30.3APOH, F5, MTHFR, F2, SERPINE1, SERPINC1
47rheumatoid arthritis30.3APOH, JAK2, MTHFR, VEGFA, IL6
48hellp syndrome30.3APOH, F5, MTHFR, VWF, SERPINE1, SERPINC1
49thrombocytosis30.3JAK2, IL6, VWF, F2, SERPINC1
50vascular disease30.3VEGFA, IL6, VWF, SERPINC1, JAK2, F8

Graphical network of the top 20 diseases related to Central Retinal Vein Occlusion:



Diseases related to central retinal vein occlusion

Clinical Features for Central Retinal Vein Occlusion

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Drugs & Therapeutics for Central Retinal Vein Occlusion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Central Retinal Vein Occlusion

Drug clinical trials:

Search ClinicalTrials for Central Retinal Vein Occlusion

Search NIH Clinical Center for Central Retinal Vein Occlusion

Search CenterWatch for Central Retinal Vein Occlusion

Genetic Tests for Central Retinal Vein Occlusion

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Anatomical Context for Central Retinal Vein Occlusion

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32MalaCards
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MalaCards organs/tissues related to Central Retinal Vein Occlusion:

32
Retina, Eye, Endothelial, Myeloid, Colon, Liver, Skin

Animal Models for Central Retinal Vein Occlusion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Central Retinal Vein Occlusion:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.4G6PD, F2, SERPINF1
2MP:00053919.4SERPINF1, PLAT
3MP:00107718.9VEGFA, IL6, F2
4MP:00036318.8F5, F2, PLAT, SERPINC1, SERPINF1
5MP:00053898.8F8, MTHFR, VEGFA, SERPINC1, SERPINF1
6MP:00053908.7PLAT, IL6, VEGFA, JAK2
7MP:00053817.4VEGFA, IL6, VWF, F2, PLAT, SERPINF1
8MP:00053786.9G6PD, JAK2, F5, MTHFR, VEGFA, IL6
9MP:00053876.5F8, JAK2, VEGFA, IL6, VWF, F2
10MP:00053976.2F8, G6PD, JAK2, VEGFA, IL6, VWF
11MP:00053765.5SERPINC1, APOH, F8, G6PD, JAK2, F5
12MP:00107685.5F5, JAK2, G6PD, F8, APOH, MTHFR

Publications for Central Retinal Vein Occlusion

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50PubMed
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Articles related to Central Retinal Vein Occlusion:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Aqueous flare and inflammatory factors in macular edema with central retinal vein occlusion: a case series. (24325604)
2013
2
Enhanced depth imaging optical coherence tomography of the choroid in central retinal vein occlusion. (23688711)
2013
3
Macular infarction following intravitreal bevacizumab for treatment of central retinal vein occlusion. (22823029)
2012
4
Macular edema in central retinal vein occlusion: correlation between optical coherence tomography, angiography and visual acuity. (22562161)
2012
5
Resolution of Persistent Cystoid Macular Edema due to Central Retinal Vein Occlusion in a Vitrectomized Eye following Intravitreal Implant of Dexamethasone 0.7 mg. (22615698)
2012
6
Optic disc area and diameter of the central retinal vein occlusion fellow eyes, determined by optical coherence tomography. (21717883)
2011
7
Intravitreal injection of bevacizumab alone or with triamcinolone acetonide for treatment of macular edema caused by central retinal vein occlusion. (22553618)
2011
8
Simultaneous anterior and posterior segment fluorescein angiography for ischemic central retinal vein occlusion. (21484661)
2011
9
Long-term effect of early intervention with single intravitreal injection of bevacizumab followed by panretinal and macular grid photocoagulation in central retinal vein occlusion (CRVO) with macular edema: a pilot study. (21307880)
2011
10
Atherosclerotic and thrombophilic risk factors in patients with ischemic central retinal vein occlusion. (21178660)
2011
11
Sequential central retinal artery occlusion and retinal vein stasis as a result of ocular ischemic syndrome. (20408094)
2010
12
The flicker electroretinogram interocular amplitude ratio is a strong prognostic indicator of neovascularization in patients with central retinal vein occlusion. (19813018)
2010
13
Efficacy of ranibizumab in patients with macular edema secondary to central retinal vein occlusion: results from the sham-controlled ROCC study. (20591399)
2010
14
Venous retinal flow reperfusion mechanisms following radial optic neurotomy with adjunctive intraocular triamcinolone in central retinal vein occlusion. (19756692)
2010
15
Hemorrhagic Macular Infarction After Intravitreal Bevacizumab for Central Retinal Vein Occlusion. (20337314)
2010
16
Central retinal vessel blood flow after surgical treatment for central retinal vein occlusion. (20706174)
2010
17
Treating central retinal vein occlusion. (20214044)
2009
18
Effects of repeated injection of intravitreal triamcinolone on macular oedema in central retinal vein occlusion. (18507724)
2009
19
Intravitreal bevacizumab (Avastin) as a treatment of the neovascular complications of laser-induced chorioretinal anastomosis for nonischaemic central retinal vein occlusion. (19624345)
2009
20
Radial optic neurotomy for central retinal vein occlusion. (23198058)
2009
21
Radial optic neurotomy for central retinal vein occlusion: long-term retinal perfusion outcome. (19420979)
2009
22
Malnutrition and bilateral central retinal vein occlusion in a young woman: a case report. (18331629)
2008
23
Central retinal vein occlusion in an otherwise healthy child. (18773278)
2008
24
Radial optic neurotomy in central retinal vein occlusion: comparison of outcome in younger vs older patients. (17113557)
2007
25
Long-term effects of radial optic neurotomy for central retinal vein occlusion consecutive interventional case series. (17406885)
2007
26
Intravitreal triamcinolone acetonide for treatment of serous macular detachment in central retinal vein occlusion. (18040239)
2007
27
Two-year results of intravitreal triamcinolone acetonide injection for the treatment of macular edema due to central retinal vein occlusion. (18025651)
2007
28
Anticoagulant therapy after retinal vein occlusion in patients with protein S deficiency (Protein S deficiency with homozygous factor V Leiden mutation in central retinal vein occlusion. Vol. 42[4]). (18059510)
2007
29
Natural history of non-ischemic central retinal vein occlusion versus iatrogenic intervention. (18097120)
2007
30
Retinal blood flow and macular edema after radial optic neurotomy for central retinal vein occlusion. (17011887)
2006
31
Visual field defects after radial optic neurotomy for central retinal vein occlusion. (16770262)
2006
32
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
33
Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. 1981. (16049359)
2005
34
Radial optic neurotomy in central retinal vein occlusion. (16137972)
2005
35
Role of early radial optic neurotomy in central retinal vein occlusion. (16137974)
2005
36
Submacular placoid pigment epithelial alteration after resolution of macular edema in central retinal vein occlusion. (15933608)
2005
37
Hyperhomocysteinemia and the methylenetetrahydrofolate reductase 677C-T mutation in patients under 50 years of age affected by central retinal vein occlusion. (15121372)
2004
38
Radial optic neurotomy as treatment for central retinal vein occlusion. (15183826)
2004
39
Is optic nerve head swelling of prognostic value in central retinal vein occlusion? (12719999)
2003
40
Multifocal electroretinographic features of central retinal vein occlusion. (14578422)
2003
41
Central retinal vein occlusion in bird-shot retinochoroidopathy. (12096977)
2002
42
Treatment of central retinal vein occlusion by vitrectomy with lysis of vitreopapillary and epipapillary adhesions, subretinal peripapillary tissue plasminogen activator injection, and photocoagulation. (12383824)
2002
43
Case records of Massachusetts General Hospital. Weekly clinicopathological exercises. Case 6-2002. A 54-year-old woman with left, then right, central-retinal-vein occlusion. (11856800)
2002
44
Central retinal vein occlusion in two patients with inflammatory bowel disease. (11131430)
2000
45
The formation and involution of optociliary veins during the course of central retinal vein occlusion. (10913654)
2000
46
Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion. (10634554)
1999
47
Vascular endothelial growth factor upregulation in human central retinal vein occlusion. (9499769)
1998
48
Activated protein C resistance in young adults with central retinal vein occlusion. (8703855)
1996
49
Experimental retinal vascular occlusion. III. An ultrastructural study of simultaneous occlusion of central retinal vein and artery. (3721722)
1986
50
Macular holes associated with central retinal vein occlusion. (5152652)
1971

Genetic Variations for Central Retinal Vein Occlusion

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Expression for genes affiliated with Central Retinal Vein Occlusion

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Retinal Vein Occlusion

Search GEO for disease gene expression data for Central Retinal Vein Occlusion.

Pathways for genes affiliated with Central Retinal Vein Occlusion

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore, 29KEGG, 52R&D Systems
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Pathways related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0SERPINE1
29.7SERPINE1, PLAT
3
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9.5SERPINF1, JAK2
4
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9.4F5, F2, SERPINC1
5
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9.4VWF, F2
6
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9.2F8, JAK2, F5, VEGFA
7
Translation Insulin regulation of translation
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9.0JAK2, VEGFA, PLAT, SERPINE1
8
Immune response Oncostatin M signaling via JAK-Stat in human cells
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8.9IL6, VEGFA, JAK2
98.8SERPINE1, IL6, VEGFA
10
Development PDGF signaling via STATs and NF-kB
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8.8F2, IL6, JAK2
11
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8.7SERPINE1, IL6, JAK2
12
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8.5SERPINC1, SERPINE1, F2, F5, F8
13
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8.4F8, F5, VEGFA, VWF, SERPINE1
148.3JAK2, VEGFA, IL6, VWF
158.1SERPINE1, PLAT, F2, IL6, MTHFR
16
Hide members
7.6SERPINC1, F8, F5, VWF, F2, PLAT
17
Hide members
7.6F8, F5, VWF, F2, PLAT, SERPINE1

Compounds for genes affiliated with Central Retinal Vein Occlusion

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 191)
idCompoundScoreTop Affiliating Genes
1estrogen4410.3APOH, F8
2warfarin44 49 11 2412.7SERPINC1, VWF, APOH
3creatinine449.6APOH, F8, F5, F2
4spectrozyme449.5F2, F5, PLAT, SERPINC1
5kaolin449.5F8, APOH, F2, F5
6fondaparinux449.5F5, PLAT, SERPINC1, F2
7bivalirudin44 1110.5F5, F2, PLAT, SERPINC1
8argatroban44 1110.5F2, SERPINC1, F5, PLAT
9phosphatidylserine44 28 1111.4F8, APOH, F2
10protamine sulfate449.4F5, F2, PLAT, SERPINC1
11batroxobin449.4F5, SERPINE1, PLAT, F2
12aspartate449.3F2, JAK2, G6PD, F8
13serine449.2JAK2, SERPINF1, G6PD, F8
14Drotrecogin alfa119.2F8, F5, F2, SERPINE1
15heparin44 28 11 2412.2VEGFA, SERPINF1, MTHFR, F8, APOH
16pge1449.1APOH, F5, F2, PLAT, SERPINE1
17ancrod449.1F2, F5, SERPINC1, SERPINE1, PLAT
18ppack449.0PLAT, VWF, F2, SERPINC1
19gabexate mesilate449.0IL6, PLAT, F5, SERPINC1
20hydroxyethyl starch449.0SERPINC1, F2, VWF, F8
21dextran sulfate449.0IL6, F5, JAK2, APOH
22cyclosporin a44 28 5910.9F2, JAK2, F8
2311-dehydrothromboxane b2448.9VWF, F2, SERPINE1, APOH
24aprotinin44 119.9SERPINC1, F5, VWF, PLAT, SERPINE1
25vitamin b12448.9F5, APOH, G6PD, MTHFR, VWF
26tirofiban44 119.9SERPINC1, PLAT, F2, VWF
27dermatan sulfate448.8F2, SERPINC1, VWF, F5, PLAT
28cyclophosphamide44 49 1110.8F5, APOH, F8, G6PD, MTHFR, VWF
29perindopril44 49 1110.8VWF, SERPINE1, PLAT, VEGFA
30ristocetin448.6F2, VWF, F5, PLAT, SERPINC1, F8
31folate448.6MTHFR, F5, G6PD, APOH, SERPINC1, VWF
32citrate448.4SERPINC1, F2, VWF, F5, G6PD, F8
33dexamethasone44 49 28 1111.4VEGFA, SERPINF1, IL6, F8
34ascorbic acid44 249.3JAK2, PLAT, MTHFR, F5, G6PD, SERPINC1
35tranexamic acid44 119.3F2, VWF, F8, SERPINC1, SERPINE1, PLAT
36protamine448.2SERPINE1, SERPINC1, F5, PLAT, F2, IL6
37kininogen448.2SERPINC1, SERPINE1, F2, VWF, F5, PLAT
38desmopressin44 59 28 1111.1F2, VWF, F5, F8, PLAT, SERPINE1
39hirudin448.1SERPINC1, SERPINE1, PLAT, F2, VWF, F5
40atorvastatin44 49 28 11 2412.0PLAT, VWF, IL6, VEGFA, F5, SERPINE1
41endotoxin448.0APOH, JAK2, F5, IL6, SERPINE1, F8
42prostacyclin448.0PLAT, F8, SERPINC1, SERPINE1, APOH, VWF
43simvastatin44 49 59 28 11 2412.6IL6, F2, F5, PLAT, VEGFA, SERPINE1
44epinephrine44 11 249.6VWF, JAK2, F5, G6PD, F8, F2
45homocysteine44 248.6APOH, F5, MTHFR, VWF, F8, F2
46n acetylcysteine447.1G6PD, JAK2, VEGFA, IL6, VWF, SERPINF1
47cholesterol44 28 11 2410.1F8, APOH, IL6, SERPINE1, MTHFR, F5
48aspirin44 49 28 249.8SERPINC1, SERPINE1, APOH, F8, G6PD, JAK2
49fibrinogen446.7SERPINC1, SERPINE1, PLAT, F2, VWF, MTHFR
50vegf446.5APOH, SERPINC1, SERPINE1, VWF, VEGFA, JAK2

GO Terms for genes affiliated with Central Retinal Vein Occlusion

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16Gene Ontology
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Cellular components related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.3F8, F5, VEGFA, VWF, SERPINE1
2extracellular matrixGO:0310128.3VWF, PLAT, SERPINE1, SERPINF1, APOH
3extracellular spaceGO:0056156.4SERPINF1, APOH, F8, F5, VEGFA, IL6
4extracellular regionGO:0055765.7F8, F5, VEGFA, IL6, VWF, F2

Biological processes related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.1PLAT, APOH
2negative regulation of proteolysisGO:0458619.8PLAT, F2
3negative regulation of blood coagulationGO:0301959.6APOH, SERPINE1
4negative regulation of fibrinolysisGO:0519189.5SERPINE1, F2, APOH
5positive regulation of blood coagulationGO:0301949.5APOH, F2, SERPINE1
6fibrinolysisGO:0427309.5SERPINE1, PLAT, F2
7positive regulation of protein import into nucleus, translocationGO:0331609.3IL6, JAK2
8negative regulation of endopeptidase activityGO:0109519.3SERPINF1, SERPINC1, SERPINE1
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1JAK2, VEGFA, IL6
10blood coagulation, intrinsic pathwayGO:0075979.1F2, VWF, F8, APOH
11acute-phase responseGO:0069539.0F8, IL6, F2
12regulation of cell shapeGO:0083608.9F2, IL6, VEGFA
13platelet degranulationGO:0025768.7F8, F5, VEGFA, VWF, SERPINE1
14positive regulation of cell proliferationGO:0082848.2F2, IL6, VEGFA, JAK2
15platelet activationGO:0301687.4F8, F5, VEGFA, IL6, VWF, F2
16blood coagulationGO:0075967.2SERPINC1, F8, JAK2, F5, VEGFA, VWF

Molecular functions related to Central Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.6SERPINC1, VEGFA, APOH
2protease bindingGO:0020208.9VWF, SERPINE1, SERPINC1
3serine-type endopeptidase inhibitor activityGO:0048678.8SERPINF1, SERPINC1, SERPINE1
4protein bindingGO:0055156.4SERPINC1, APOH, F8, G6PD, JAK2, F5

Products for genes affiliated with Central Retinal Vein Occlusion

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Retinal Vein Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet