MCID: CNT060
MIFTS: 42

Central Serous Chorioretinopathy malady

Rare diseases, Bone diseases, Immune diseases categories
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Summaries for Central Serous Chorioretinopathy

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NIH Rare Diseases:42 Central serous chorioretinopathy is a disease that causes fluid to build up under the retina, the back part of the inner eye that sends sight information to the brain. the fluid leaks from the choroid (the blood vessel layer under the retina). the cause of this condition is unknown but stress can be a risk factor. signs and symptoms include dim and blurred blind spot in the center of vision, distortion of straight lines and seeing objects as smaller or farther away. many cases of central serous chorioretinopathy improve without treatment after 1-2 months. laser treatment may be an option for other individuals. last updated: 1/30/2014

MalaCards based summary: Central Serous Chorioretinopathy, also known as central serous choroidopathy, is related to hypertension and retinitis. An important gene associated with Central Serous Chorioretinopathy is SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), and among its related pathways are Senescence and Autophagy and Translation Insulin regulation of translation. The compounds notoginsenoside r1 and batroxobin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone marrow.

Wikipedia:65 Central serous retinopathy (CSR), also known as central serous chorioretinopathy (CSC), is an eye... more...

Aliases & Classifications for Central Serous Chorioretinopathy

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Central Serous Chorioretinopathy, Aliases & Descriptions:

Name: Central Serous Chorioretinopathy 42 62
Central Serous Choroidopathy 42 62
 
Central Serous Chorioretinopathy After Bone Marrow Transplantation 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Immune diseases


Related Diseases for Central Serous Chorioretinopathy

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Graphical network of the top 20 diseases related to Central Serous Chorioretinopathy:



Diseases related to central serous chorioretinopathy

Symptoms for Central Serous Chorioretinopathy

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Drugs & Therapeutics for Central Serous Chorioretinopathy

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Drug clinical trials:

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Genetic Tests for Central Serous Chorioretinopathy

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Anatomical Context for Central Serous Chorioretinopathy

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MalaCards organs/tissues related to Central Serous Chorioretinopathy:

32
Eye, Retina, Bone marrow, Bone, Brain, Endothelial, Cortex, Heart, Skin, Testes, B cells, Adrenal cortex

Animal Models for Central Serous Chorioretinopathy or affiliated genes

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Publications for Central Serous Chorioretinopathy

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Articles related to Central Serous Chorioretinopathy:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Helicobacter pylori as a risk factor for central serous chorioretinopathy: Literature review. (25133035)
2014
2
Success of Ranibizumab in Central Serous Chorioretinopathy Resistant to Bevacizumab. (25216333)
2014
3
Assessment of choroidal topographic changes by swept source optical coherence tomography after photodynamic therapy for central serous chorioretinopathy. (24412124)
2014
4
Current concepts in managing central serous chorioretinopathy. (24392907)
2014
5
Effects of smoking on visual acuity of central serous chorioretinopathy patients. (23841829)
2013
6
Getting serious with retinopathy: approaching an integrated hypothesis for central serous chorioretinopathy. (23669373)
2013
7
Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography. (24171107)
2013
8
Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy. (24365176)
2013
9
Central serous chorioretinopathy due to tadalafil use. (23065016)
2013
10
Cushing disease revealed by bilateral atypical central serous chorioretinopathy: case report. (24013974)
2013
11
New guidelines in the treatment of persistent central serous chorioretinopathy: PDT with half-dose verteporfin. (22495997)
2012
12
Central serous chorioretinopathy after blunt trauma. (22669212)
2012
13
Correlation of spectral domain optical coherence tomography findings in acute central serous chorioretinopathy with visual acuity. (23225998)
2012
14
Correlations among various functional and morphological tests in resolved central serous chorioretinopathy. (21617156)
2012
15
Central serous chorioretinopathy in myopic patients. (23044956)
2012
16
Intravitreal bevacizumab for choroidal neovascularization secondary to laser photocoagulation for central serous chorioretinopathy. (21928270)
2012
17
Improvement in multifocal electroretinography after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy: a randomized placebo-controlled trial. (21836413)
2011
18
Persistent subretinal fluid due to central serous chorioretinopathy after retinal detachment surgery. (22069347)
2011
19
Central serous chorioretinopathy mistaken for tuberculous choroiditis. (22454755)
2011
20
Review and update of central serous chorioretinopathy. (21427570)
2011
21
Bilateral central serous chorioretinopathy resolving rapidly with treatment for obstructive sleep apnea. (20049474)
2010
22
Cirrus HD-OCT high definition imaging is another tool available for visualization of the choroid and provides agreement with the finding that the choroidal thickness is increased in central serous chorioretinopathy in comparison to normal eyes. (20827146)
2010
23
Intravitreal bevacizumab injection for central serous chorioretinopathy. (20010322)
2010
24
Retinal thickness and perimetric sensitivity in central serous chorioretinopathy. (21191719)
2010
25
Correlation of retinal sensitivity and retinal thickness in central serous chorioretinopathy. (19684422)
2010
26
Intravitreal Bevacizumab for the Treatment of Central Serous Chorioretinopathy. (20429499)
2010
27
Central serous chorioretinopathy resulting in altered vision and color perception after glenohumeral corticosteroid injection. (19708628)
2009
28
Photodynamic therapy for chronic pigment epithelial detachment in central serous chorioretinopathy. (19491970)
2009
29
The optical coherence tomography-ophthalmoscope for examination of central serous chorioretinopathy with precipitates. (18536604)
2008
30
Photodynamic therapy as treatment of chronic idiopathic central serous chorioretinopathy. (19065564)
2008
31
Obstructive sleep apnea in patients with central serous chorioretinopathy. (18546012)
2008
32
Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy. (16936642)
2008
33
Elongation of photoreceptor outer segment in central serous chorioretinopathy. (18028861)
2008
34
Successful outcome of giant retinal pigment epithelium rip in idiopathic central serous chorioretinopathy. (18301045)
2008
35
Selective retina therapy in patients with central serous chorioretinopathy. (16758179)
2006
36
Safety enhanced photodynamic therapy with half dose verteporfin for chronic central serous chorioretinopathy: a short term pilot study. (16597666)
2006
37
Current and future role of photodynamic therapy in chronic central serous chorioretinopathy. (15734027)
2005
38
Central serous chorioretinopathy and glucocorticoids. (14711450)
2004
39
Indocyanine green dye-enhanced micropulsed diode laser: a novel approach to subthreshold RPE treatment in a case of central serous chorioretinopathy. (15005592)
2004
40
Effect of catecholamine on central serous chorioretinopathy. (14526445)
2003
41
Cystoid macular degeneration in chronic central serous chorioretinopathy. (12652224)
2003
42
Central serous chorioretinopathy. (12770954)
2003
43
Central serous chorioretinopathy associated with adrenal myelolipoma. (12664380)
2003
44
Indocyanine green-mediated photothrombosis as a new technique of treatment for persistent central serous chorioretinopathy. (12658548)
2002
45
Long-term follow-up of idiopathic central serous chorioretinopathy without laser. (11453866)
2001
46
Surgical management of exudative retinal detachment associated with central serous chorioretinopathy. (11125275)
2001
47
Retinal pigment epithelial tears associated with idiopathic central serous chorioretinopathy. (11340893)
2000
48
Polypoidal choroidal vasculopathy masquerading as central serous chorioretinopathy. (10768341)
2000
49
Bullous variant of idiopathic central serous chorioretinopathy. (10781512)
2000
50
Central serous chorioretinopathy complicating solar retinopathy treated with glucocorticoids. (9987635)
1999

Variations for Central Serous Chorioretinopathy

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Expression for genes affiliated with Central Serous Chorioretinopathy

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Expression patterns in normal tissues for genes affiliated with Central Serous Chorioretinopathy

Search GEO for disease gene expression data for Central Serous Chorioretinopathy.

Pathways for genes affiliated with Central Serous Chorioretinopathy

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Pathways related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1PLAT, SERPINE1
2
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1PLAT, SERPINE1
3
Show member pathways
9.1PLAT, SERPINE1
4
Show member pathways
9.1SERPINE1, PLAT
5
Show member pathways
thioredoxin pathway37
9.1PLAT, SERPINE1
6
Show member pathways
9.1PLAT, SERPINE1
7
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.1PLAT, SERPINE1
89.1PLAT, SERPINE1

Compounds for genes affiliated with Central Serous Chorioretinopathy

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Compounds related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1notoginsenoside r1449.6PLAT, SERPINE1
2batroxobin449.6PLAT, SERPINE1
3eaca449.6PLAT, SERPINE1
4p-amino benzamidine449.6SERPINE1, PLAT
5ancrod449.6SERPINE1, PLAT
6chloramine t449.6PLAT, SERPINE1
7quinapril44 50 1111.6SERPINE1, PLAT
8tranexamic acid44 1110.6PLAT, SERPINE1
9epsilon aminocaproic acid449.6SERPINE1, PLAT
10perindopril44 50 1111.6SERPINE1, PLAT
11fucoidan449.6PLAT, SERPINE1
12hydrochlorothiazide44 28 50 24 1113.6PLAT, SERPINE1
13enalapril44 50 1111.5SERPINE1, PLAT
14diisopropylfluorophosphate449.5PLAT, SERPINE1
15gemfibrozil28 44 1111.5PLAT, SERPINE1
16desmopressin44 61 28 1112.5SERPINE1, PLAT
17hirudin449.5PLAT, SERPINE1
18p005449.5PLAT, SERPINE1
19protamine449.5SERPINE1, PLAT
20kininogen449.5PLAT, SERPINE1
21fluvastatin44 50 28 1112.5PLAT, SERPINE1
22losartan44 50 28 1112.5SERPINE1, PLAT
23pge1449.5PLAT, SERPINE1
24aprotinin44 1110.5PLAT, SERPINE1
25p003449.5SERPINE1, PLAT
26sodium nitroprusside449.5PLAT, SERPINE1
27homocysteine44 2410.5PLAT, SERPINE1
28atorvastatin44 50 28 24 1113.5SERPINE1, PLAT
29troglitazone44 28 61 1112.5PLAT, SERPINE1
305-hydroxytryptamine449.5PLAT, SERPINE1
31simvastatin44 50 61 28 24 1114.5SERPINE1, PLAT
32heparan sulfate44 2410.5PLAT, SERPINE1
33isoproterenol44 1110.4PLAT, SERPINE1
34prostacyclin449.4SERPINE1, PLAT
35nicotine44 28 50 1112.4PLAT, SERPINE1
36aspirin44 50 28 2412.4PLAT, SERPINE1
37gnrh449.4SERPINE1, PLAT
38chloramphenicol44 2 50 1112.4PLAT, SERPINE1
39matrigel449.4PLAT, SERPINE1
40fibrinogen449.4SERPINE1, PLAT
41actinomycin d449.3PLAT, SERPINE1
42estradiol44 24 1111.3PLAT, SERPINE1
43creatinine449.3SERPINE1, PLAT
44aspartate449.2PLAT, SERPINE1
45heparin44 28 24 1112.2PLAT, SERPINE1
46adenylate449.1SERPINE1, PLAT
47cholesterol44 28 24 1112.1PLAT, SERPINE1
48cycloheximide449.0PLAT, SERPINE1
49progesterone44 28 61 24 1112.8PLAT, SERPINE1

GO Terms for genes affiliated with Central Serous Chorioretinopathy

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Cellular components related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1PLAT, SERPINE1

Biological processes related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1PLAT, SERPINE1
2fibrinolysisGO:0427308.8PLAT, SERPINE1

Products for genes affiliated with Central Serous Chorioretinopathy

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Sources for Central Serous Chorioretinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet