MCID: CNT060
MIFTS: 28

Central Serous Chorioretinopathy malady

Bone diseases, Immune diseases categories

Summaries for Central Serous Chorioretinopathy

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Central serous chorioretinopathy is a disease that causes fluid to build up under the retina, the back part of the inner eye that sends sight information to the brain. the fluid leaks from the choroid (the blood vessel layer under the retina). the cause of this condition is unknown but stress can be a risk factor. signs and symptoms include dim and blurred blind spot in the center of vision, distortion of straight lines and seeing objects as smaller or farther away. many cases of central serous chorioretinopathy improve without treatment after 1-2 months. laser treatment may be an option for other individuals. last updated: 1/30/2014

MalaCards: Central Serous Chorioretinopathy, also known as central serous chorioretinopathy after bone marrow transplantation, is related to age related macular degeneration and antiphospholipid syndrome. An important gene associated with Central Serous Chorioretinopathy is SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), and among its related pathways are Senescence and Autophagy and Translation Insulin regulation of translation. The compounds notoginsenoside r1 and batroxobin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone.

Wikipedia:63 Central serous retinopathy (CSR), also known as central serous chorioretinopathy (CSC), is an eye... more...

Aliases & Classifications for Central Serous Chorioretinopathy

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Immune diseases


Aliases & Descriptions:

central serous chorioretinopathy 42 60
central serous chorioretinopathy after bone marrow transplantation 42
central serous choroidopathy 42


Related Diseases for Central Serous Chorioretinopathy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Central Serous Chorioretinopathy:



Diseases related to central serous chorioretinopathy

Clinical Features for Central Serous Chorioretinopathy

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Drugs & Therapeutics for Central Serous Chorioretinopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Central Serous Chorioretinopathy

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Anatomical Context for Central Serous Chorioretinopathy

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32MalaCards
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MalaCards organs/tissues related to Central Serous Chorioretinopathy:

32
Eye, Retina, Bone, Brain, Bone marrow

Animal Models for Central Serous Chorioretinopathy or affiliated genes

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Publications for Central Serous Chorioretinopathy

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Genetic Variations for Central Serous Chorioretinopathy

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Expression for genes affiliated with Central Serous Chorioretinopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Serous Chorioretinopathy

Search GEO for disease gene expression data for Central Serous Chorioretinopathy.

Pathways for genes affiliated with Central Serous Chorioretinopathy

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 52R&D Systems, 29KEGG
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Pathways related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SERPINE1, PLAT
2
Translation Insulin regulation of translation
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9.1SERPINE1, PLAT
3
Cell adhesion ECM remodeling
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9.1SERPINE1, PLAT
49.1PLAT, SERPINE1
5
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9.1SERPINE1, PLAT
6
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9.1SERPINE1, PLAT
79.1SERPINE1, PLAT

Compounds for genes affiliated with Central Serous Chorioretinopathy

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1notoginsenoside r1449.6SERPINE1, PLAT
2batroxobin449.6PLAT, SERPINE1
3eaca449.6PLAT, SERPINE1
4p-amino benzamidine449.6SERPINE1, PLAT
5ancrod449.6SERPINE1, PLAT
6Urokinase119.6PLAT, SERPINE1
7chloramine t449.5SERPINE1, PLAT
8quinapril44 1110.5SERPINE1, PLAT
9tranexamic acid44 1110.5SERPINE1, PLAT
10epsilon aminocaproic acid449.5PLAT, SERPINE1
11perindopril44 49 1111.5PLAT, SERPINE1
12fucoidan449.5SERPINE1, PLAT
13hydrochlorothiazide44 49 28 11 2413.5PLAT, SERPINE1
14enalapril44 49 1111.5SERPINE1, PLAT
15diisopropylfluorophosphate449.5SERPINE1, PLAT
16gemfibrozil44 28 1111.5PLAT, SERPINE1
17desmopressin44 59 28 1112.5SERPINE1, PLAT
18hirudin449.5SERPINE1, PLAT
19p005449.5PLAT, SERPINE1
20protamine449.5SERPINE1, PLAT
21fluvastatin44 49 28 1112.5SERPINE1, PLAT
22kininogen449.5PLAT, SERPINE1
23losartan44 49 28 1112.5SERPINE1, PLAT
24pge1449.5SERPINE1, PLAT
25aprotinin44 1110.5PLAT, SERPINE1
26p003449.5SERPINE1, PLAT
27homocysteine44 2410.4PLAT, SERPINE1
28sodium nitroprusside449.4PLAT, SERPINE1
29atorvastatin44 49 28 11 2413.4SERPINE1, PLAT
30troglitazone44 28 59 1112.4PLAT, SERPINE1
315-hydroxytryptamine449.4SERPINE1, PLAT
32simvastatin44 49 59 28 11 2414.4SERPINE1, PLAT
33heparan sulfate44 2410.4PLAT, SERPINE1
34isoproterenol44 1110.4SERPINE1, PLAT
35prostacyclin449.3PLAT, SERPINE1
36nicotine44 49 28 1112.3PLAT, SERPINE1
37aspirin44 49 28 2412.3SERPINE1, PLAT
38gnrh449.2PLAT, SERPINE1
39chloramphenicol44 2 1111.2SERPINE1, PLAT
40matrigel449.1SERPINE1, PLAT
41estradiol44 11 2411.1SERPINE1, PLAT
42fibrinogen449.0PLAT, SERPINE1
43actinomycin d448.8SERPINE1, PLAT

GO Terms for genes affiliated with Central Serous Chorioretinopathy

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16Gene Ontology
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Cellular components related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1SERPINE1, PLAT

Biological processes related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.1SERPINE1, PLAT

Products for genes affiliated with Central Serous Chorioretinopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Serous Chorioretinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet