MCID: CNT060
MIFTS: 34

Central Serous Chorioretinopathy malady

Rare diseases, Bone diseases, Immune diseases categories

Aliases & Classifications for Central Serous Chorioretinopathy

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Central Serous Chorioretinopathy, Aliases & Descriptions:

Name: Central Serous Chorioretinopathy 41 60
Central Serous Chorioretinopathy After Bone Marrow Transplantation 41
 
Central Serous Choroidopathy 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Immune diseases


Summaries for Central Serous Chorioretinopathy

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NIH Rare Diseases:41 Central serous chorioretinopathy is a disease that causes fluid to build up under the retina, the back part of the inner eye that sends sight information to the brain. the fluid leaks from the choroid (the blood vessel layer under the retina). the cause of this condition is unknown but stress can be a risk factor. signs and symptoms include dim and blurred blind spot in the center of vision, distortion of straight lines and seeing objects as smaller or farther away. many cases of central serous chorioretinopathy improve without treatment after 1-2 months. laser treatment may be an option for other individuals. last updated: 1/30/2014

MalaCards based summary: Central Serous Chorioretinopathy, also known as central serous chorioretinopathy after bone marrow transplantation, is related to retinitis and choroiditis. An important gene associated with Central Serous Chorioretinopathy is SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), and among its related pathways are Senescence and Autophagy and Translation Insulin regulation of translation. The compounds notoginsenoside r1 and batroxobin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone marrow.

Related Diseases for Central Serous Chorioretinopathy

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Graphical network of the top 20 diseases related to Central Serous Chorioretinopathy:



Diseases related to central serous chorioretinopathy

Symptoms for Central Serous Chorioretinopathy

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Drugs & Therapeutics for Central Serous Chorioretinopathy

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Drug clinical trials:

Search ClinicalTrials for Central Serous Chorioretinopathy

Search NIH Clinical Center for Central Serous Chorioretinopathy

Genetic Tests for Central Serous Chorioretinopathy

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Anatomical Context for Central Serous Chorioretinopathy

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MalaCards organs/tissues related to Central Serous Chorioretinopathy:

31
Eye, Retina, Bone marrow, Bone, Brain, Endothelial, Cortex, Heart, Skin, Testes, B cells, Adrenal cortex

Animal Models for Central Serous Chorioretinopathy or affiliated genes

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Publications for Central Serous Chorioretinopathy

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Articles related to Central Serous Chorioretinopathy:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes. (25690981)
2015
2
Helicobacter pylori as a risk factor for central serous chorioretinopathy: Literature review. (25133035)
2014
3
Success of Ranibizumab in Central Serous Chorioretinopathy Resistant to Bevacizumab. (25216333)
2014
4
Assessment of choroidal topographic changes by swept source optical coherence tomography after photodynamic therapy for central serous chorioretinopathy. (24412124)
2014
5
Current concepts in managing central serous chorioretinopathy. (24392907)
2014
6
Effects of smoking on visual acuity of central serous chorioretinopathy patients. (23841829)
2013
7
Getting serious with retinopathy: approaching an integrated hypothesis for central serous chorioretinopathy. (23669373)
2013
8
Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography. (24171107)
2013
9
Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy. (24365176)
2013
10
Central serous chorioretinopathy due to tadalafil use. (23065016)
2013
11
Cushing disease revealed by bilateral atypical central serous chorioretinopathy: case report. (24013974)
2013
12
New guidelines in the treatment of persistent central serous chorioretinopathy: PDT with half-dose verteporfin. (22495997)
2012
13
Central serous chorioretinopathy after blunt trauma. (22669212)
2012
14
Correlation of spectral domain optical coherence tomography findings in acute central serous chorioretinopathy with visual acuity. (23225998)
2012
15
Correlations among various functional and morphological tests in resolved central serous chorioretinopathy. (21617156)
2012
16
Central serous chorioretinopathy in myopic patients. (23044956)
2012
17
Intravitreal bevacizumab for choroidal neovascularization secondary to laser photocoagulation for central serous chorioretinopathy. (21928270)
2012
18
Improvement in multifocal electroretinography after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy: a randomized placebo-controlled trial. (21836413)
2011
19
Persistent subretinal fluid due to central serous chorioretinopathy after retinal detachment surgery. (22069347)
2011
20
Central serous chorioretinopathy mistaken for tuberculous choroiditis. (22454755)
2011
21
Bilateral central serous chorioretinopathy resolving rapidly with treatment for obstructive sleep apnea. (20049474)
2010
22
Cirrus HD-OCT high definition imaging is another tool available for visualization of the choroid and provides agreement with the finding that the choroidal thickness is increased in central serous chorioretinopathy in comparison to normal eyes. (20827146)
2010
23
Intravitreal bevacizumab injection for central serous chorioretinopathy. (20010322)
2010
24
Retinal thickness and perimetric sensitivity in central serous chorioretinopathy. (21191719)
2010
25
Correlation of retinal sensitivity and retinal thickness in central serous chorioretinopathy. (19684422)
2010
26
Intravitreal Bevacizumab for the Treatment of Central Serous Chorioretinopathy. (20429499)
2010
27
Central serous chorioretinopathy resulting in altered vision and color perception after glenohumeral corticosteroid injection. (19708628)
2009
28
Photodynamic therapy for chronic pigment epithelial detachment in central serous chorioretinopathy. (19491970)
2009
29
The optical coherence tomography-ophthalmoscope for examination of central serous chorioretinopathy with precipitates. (18536604)
2008
30
Photodynamic therapy as treatment of chronic idiopathic central serous chorioretinopathy. (19065564)
2008
31
Obstructive sleep apnea in patients with central serous chorioretinopathy. (18546012)
2008
32
Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy. (16936642)
2008
33
Elongation of photoreceptor outer segment in central serous chorioretinopathy. (18028861)
2008
34
The value of contrast sensitivity in diagnosing central serous chorioretinopathy. (17535369)
2007
35
Selective retina therapy in patients with central serous chorioretinopathy. (16758179)
2006
36
Safety enhanced photodynamic therapy with half dose verteporfin for chronic central serous chorioretinopathy: a short term pilot study. (16597666)
2006
37
Current and future role of photodynamic therapy in chronic central serous chorioretinopathy. (15734027)
2005
38
Central serous chorioretinopathy and glucocorticoids. (14711450)
2004
39
Indocyanine green dye-enhanced micropulsed diode laser: a novel approach to subthreshold RPE treatment in a case of central serous chorioretinopathy. (15005592)
2004
40
Effect of catecholamine on central serous chorioretinopathy. (14526445)
2003
41
Cystoid macular degeneration in chronic central serous chorioretinopathy. (12652224)
2003
42
Central serous chorioretinopathy. (12770954)
2003
43
Central serous chorioretinopathy associated with adrenal myelolipoma. (12664380)
2003
44
Indocyanine green-mediated photothrombosis as a new technique of treatment for persistent central serous chorioretinopathy. (12658548)
2002
45
Long-term follow-up of idiopathic central serous chorioretinopathy without laser. (11453866)
2001
46
Surgical management of exudative retinal detachment associated with central serous chorioretinopathy. (11125275)
2001
47
Retinal pigment epithelial tears associated with idiopathic central serous chorioretinopathy. (11340893)
2000
48
Polypoidal choroidal vasculopathy masquerading as central serous chorioretinopathy. (10768341)
2000
49
Bullous variant of idiopathic central serous chorioretinopathy. (10781512)
2000
50
Central serous chorioretinopathy complicating solar retinopathy treated with glucocorticoids. (9987635)
1999

Variations for Central Serous Chorioretinopathy

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Expression for genes affiliated with Central Serous Chorioretinopathy

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Search GEO for disease gene expression data for Central Serous Chorioretinopathy.

Pathways for genes affiliated with Central Serous Chorioretinopathy

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Pathways related to Central Serous Chorioretinopathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1PLAT, SERPINE1
2
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.1PLAT, SERPINE1
3
Show member pathways
9.1PLAT, SERPINE1
4
Show member pathways
Metalloproteases in connective tissue degradation
9.1SERPINE1, PLAT
5
Show member pathways
thioredoxin pathway36
9.1PLAT, SERPINE1
6
Show member pathways
9.1PLAT, SERPINE1
7
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.1PLAT, SERPINE1
89.1PLAT, SERPINE1

Compounds for genes affiliated with Central Serous Chorioretinopathy

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Compounds related to Central Serous Chorioretinopathy according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1notoginsenoside r1439.6PLAT, SERPINE1
2batroxobin439.6PLAT, SERPINE1
3eaca439.6PLAT, SERPINE1
4p-amino benzamidine439.6SERPINE1, PLAT
5ancrod439.6SERPINE1, PLAT
6chloramine t439.6PLAT, SERPINE1
7quinapril43 49 1211.6SERPINE1, PLAT
8tranexamic acid43 1210.6PLAT, SERPINE1
9epsilon aminocaproic acid439.6SERPINE1, PLAT
10perindopril43 49 1211.6SERPINE1, PLAT
11fucoidan439.6PLAT, SERPINE1
12hydrochlorothiazide43 28 49 24 1213.6PLAT, SERPINE1
13enalapril43 49 1211.5SERPINE1, PLAT
14diisopropylfluorophosphate439.5PLAT, SERPINE1
15gemfibrozil28 43 1211.5PLAT, SERPINE1
16desmopressin43 59 28 1212.5SERPINE1, PLAT
17hirudin439.5PLAT, SERPINE1
18p005439.5PLAT, SERPINE1
19protamine439.5SERPINE1, PLAT
20kininogen439.5PLAT, SERPINE1
21fluvastatin43 49 28 1212.5PLAT, SERPINE1
22losartan43 49 28 1212.5SERPINE1, PLAT
23pge1439.5PLAT, SERPINE1
24aprotinin43 1210.5PLAT, SERPINE1
25p003439.5SERPINE1, PLAT
26sodium nitroprusside439.5PLAT, SERPINE1
27homocysteine43 2410.5PLAT, SERPINE1
28atorvastatin43 49 28 24 1213.5SERPINE1, PLAT
29troglitazone43 28 59 1212.5PLAT, SERPINE1
305-hydroxytryptamine439.5PLAT, SERPINE1
31simvastatin43 49 59 28 24 1214.5SERPINE1, PLAT
32heparan sulfate43 2410.5PLAT, SERPINE1
33isoproterenol43 1210.4PLAT, SERPINE1
34prostacyclin439.4SERPINE1, PLAT
35nicotine43 28 49 1212.4PLAT, SERPINE1
36aspirin43 49 28 2412.4PLAT, SERPINE1
37gnrh439.4SERPINE1, PLAT
38chloramphenicol43 2 49 1212.4PLAT, SERPINE1
39matrigel439.4PLAT, SERPINE1
40fibrinogen439.4SERPINE1, PLAT
41actinomycin d439.3PLAT, SERPINE1
42estradiol43 24 1211.3PLAT, SERPINE1
43creatinine439.3SERPINE1, PLAT
44aspartate439.2PLAT, SERPINE1
45heparin43 28 24 1212.2PLAT, SERPINE1
46adenylate439.1SERPINE1, PLAT
47cholesterol43 28 24 1212.1PLAT, SERPINE1
48cycloheximide439.0PLAT, SERPINE1
49progesterone43 28 59 24 1212.8PLAT, SERPINE1

GO Terms for genes affiliated with Central Serous Chorioretinopathy

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Cellular components related to Central Serous Chorioretinopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310129.1PLAT, SERPINE1

Biological processes related to Central Serous Chorioretinopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00075969.1PLAT, SERPINE1
2fibrinolysisGO:00427308.8PLAT, SERPINE1

Products for genes affiliated with Central Serous Chorioretinopathy

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Sources for Central Serous Chorioretinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet