MCID: CNT060
MIFTS: 35

Central Serous Chorioretinopathy malady

Bone, Immune categories

Summaries for Central Serous Chorioretinopathy

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Central serous chorioretinopathy is a disease that causes fluid to build up under the retina, the back part of the inner eye that sends sight information to the brain. the fluid leaks from the choroid (the blood vessel layer under the retina). the cause of this condition is unknown but stress can be a risk factor. signs and symptoms include dim and blurred blind spot in the center of vision, distortion of straight lines and seeing objects as smaller or farther away. many cases of central serous chorioretinopathy improve without treatment after 1-2 months. laser treatment may be an option for other individuals. last updated: 1/30/2014

MalaCards: Central Serous Chorioretinopathy, also known as central serous chorioretinopathy after bone marrow transplantation, is related to antiphospholipid syndrome and vascular disease. An important gene associated with Central Serous Chorioretinopathy is SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), and among its related pathways are Senescence and Autophagy and Translation Insulin regulation of translation. The compounds notoginsenoside r1 and batroxobin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cortex.

Wikipedia:64 Central serous retinopathy (CSR), also known as central serous chorioretinopathy (CSC), is an eye... more...

Aliases & Classifications for Central Serous Chorioretinopathy

Sources:
43NIH Rare Diseases, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone, Immune


Aliases & Descriptions:

central serous chorioretinopathy 43 61
central serous chorioretinopathy after bone marrow transplantation 43
central serous choroidopathy 43


Related Diseases for Central Serous Chorioretinopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Central Serous Chorioretinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1antiphospholipid syndrome30.4PLAT
2vascular disease30.3SERPINE1, PLAT
3central sleep apnea10.6
4sleep apnea10.6
5choroiditis10.4
6macular holes10.3
7hallermann-streiff syndrome10.3
8solar retinopathy10.3
9cushing's syndrome10.3
10systemic lupus erythematosus10.3
11retinitis pigmentosa10.3
12scotoma10.3
13alexithymia10.3
14ulcerative colitis10.3
15gastroesophageal reflux disease10.3
16vitelliform macular dystrophy10.3
17adrenal carcinoma10.3
18acute leukemia10.3
19adenoma10.3
20angioedema10.3
21uveitis10.3
22macular dystrophy, atypical vitelliform10.3
23macular dystrophy10.3
24coronary heart disease10.3
25blindness10.3
26hyperopia10.3
27central retinal artery occlusion10.0PLAT
28central retinal vein occlusion10.0PLAT
29pulmonary embolism10.0PLAT
30age related macular degeneration10.0PLAT
31hellp syndrome10.0SERPINE1
32arteriosclerosis10.0SERPINE1
33hypercholesterolemia10.0SERPINE1
34diabetic retinopathy10.0SERPINE1
35polycystic ovary syndrome10.0SERPINE1
36hepatic vein thrombosis10.0SERPINE1, PLAT
37coronary thrombosis10.0PLAT, SERPINE1
38hemorrhagic disease10.0SERPINE1, PLAT
39venous thrombosis10.0SERPINE1, PLAT
40thrombophilia10.0SERPINE1, PLAT
41disseminated intravascular coagulation10.0PLAT, SERPINE1
42hyperhomocysteinemia10.0SERPINE1, PLAT
43ischemic heart disease10.0PLAT, SERPINE1
44hypertriglyceridemia10.0SERPINE1, PLAT
45stroke, ischemic10.0PLAT, SERPINE1
46factor v leiden thrombophilia10.0SERPINE1, PLAT
47pre-eclampsia10.0PLAT, SERPINE1
48thromboembolism10.0SERPINE1, PLAT
49hyperglycemia10.0SERPINE1
50coronary artery disease,10.0PLAT, SERPINE1

Graphical network of the top 20 diseases related to Central Serous Chorioretinopathy:



Diseases related to central serous chorioretinopathy

Clinical Features for Central Serous Chorioretinopathy

Drugs & Therapeutics for Central Serous Chorioretinopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Central Serous Chorioretinopathy

Drug clinical trials:

Search ClinicalTrials for Central Serous Chorioretinopathy

Search NIH Clinical Center for Central Serous Chorioretinopathy

Search CenterWatch for Central Serous Chorioretinopathy

Genetic Tests for Central Serous Chorioretinopathy

Anatomical Context for Central Serous Chorioretinopathy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Central Serous Chorioretinopathy:

33
Bone marrow, Brain, Cortex, Retina, Heart, Skin, B lymphoblasts, B cells, Endothelial, Adrenal cortex

Animal Models for Central Serous Chorioretinopathy or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Central Serous Chorioretinopathy

Sources:
51PubMed
See all sources

Articles related to Central Serous Chorioretinopathy:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Current concepts in managing central serous chorioretinopathy. (24392907)
2014
2
Changes in choroidal thickness after photodynamic therapy in patients with central serous chorioretinopathy. (24219859)
2014
3
Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy. (24365176)
2013
4
Central serous chorioretinopathy due to tadalafil use. (23065016)
2013
5
Serum cortisol and testosterone levels in chronic central serous chorioretinopathy. (22718204)
2013
6
Bilateral central serous chorioretinopathy with retinal pigment epithelium tears following epidural steroid injection. (24104712)
2013
7
The efficacy of intravitreal bevacizumab for acute central serous chorioretinopathy. (22925113)
2013
8
Intravitreal ranibizumab for acute central serous chorioretinopathy. (23257663)
2013
9
Central serous chorioretinopathy produces macular pigment profile changes. (23770658)
2013
10
DOES MICROPERIMETRY HAVE A PROGNOSTIC VALUE IN CENTRAL SEROUS CHORIORETINOPATHY? (23975001)
2013
11
Outer retinal tubulations in chronic central serous chorioretinopathy. (22955718)
2013
12
Photodynamic therapy for chronic central serous chorioretinopathy: a 4-year follow-up study. (23095766)
2013
13
CHARACTERISTICS OF CENTRAL SEROUS CHORIORETINOPATHY COMPLICATED BY FOCAL CHOROIDAL EXCAVATION. (24240563)
2013
14
Full-thickness macular hole formation associated with central serous chorioretinopathy. (22729443)
2012
15
Long-term results of half-fluence photodynamic therapy for chronic central serous chorioretinopathy. (21928269)
2012
16
Correlation of integrity of cone outer segment tips line with retinal sensitivity after half-dose photodynamic therapy for chronic central serous chorioretinopathy. (22818904)
2012
17
Transpupillary thermotherapy for atypical central serous chorioretinopathy. (22331974)
2012
18
Subretinal dot-like precipitates and yellow material in central serous chorioretinopathy. (21052035)
2011
19
Intravitreal bevacizumab injection for central serous chorioretinopathy. (21260959)
2011
20
Aqueous humor and plasma levels of vascular endothelial growth factor and interleukin-8 in patients with central serous chorioretinopathy. (20526231)
2010
21
Clinical factors related to visual outcome in central serous chorioretinopathy. (20616688)
2010
22
Transpupillary Thermotherapy for Juxtafoveal Leak in Central Serous Chorioretinopathy. (20337348)
2010
23
Central serous chorioretinopathy and phosphodiesterase-5 inhibitors: a case-control postmarketing surveillance study. (20010456)
2010
24
Role of Avastin in management of central serous chorioretinopathy. (23960879)
2010
25
Central serous chorioretinopathy after dacryocystorhinostomy operation on the same side. (19075414)
2009
26
Helicobacter pylori--a risk factor for the developement of the central serous chorioretinopathy. (19517842)
2009
27
Nonvisible subthreshold micropulse diode laser (810 nm) treatment of central serous chorioretinopathy. A pilot study. (18988165)
2008
28
Risk factors for posterior cystoid retinal degeneration in central serous chorioretinopathy. (18779722)
2008
29
Relation of optical coherence tomography and unusual angiographic leakage patterns in central serous chorioretinopathy. (17464304)
2008
30
Half-dose verteporfin photodynamic therapy for acute central serous chorioretinopathy: one-year results of a randomized controlled trial. (18538401)
2008
31
The value of contrast sensitivity in diagnosing central serous chorioretinopathy. (17535369)
2007
32
Assessment of central serous chorioretinopathy by optical coherence tomography and multifocal electroretinography. (17728550)
2007
33
Choroidal neovascularization following photodynamic therapy in a patient with chronic central serous chorioretinopathy. (17894291)
2007
34
Safety enhanced photodynamic therapy with half dose verteporfin for chronic central serous chorioretinopathy: a short term pilot study. (16597666)
2006
35
Central serous chorioretinopathy and Helicobacter pylori. (16703546)
2006
36
Central serous chorioretinopathy associated with testosterone therapy. (15846380)
2006
37
Three-dimensional optical coherence tomographic findings in central serous chorioretinopathy. (16596405)
2006
38
Photodynamic therapy for focal retinal pigment epithelial leaks secondary to central serous chorioretinopathy. (16325707)
2005
39
Intravitreal triamcinolone acetonide and central serous chorioretinopathy. (15722324)
2005
40
Central serous chorioretinopathy in patients receiving systemic corticosteroid therapy. (16049541)
2005
41
Ocular photodynamic therapy in choroidal neovascularization complicating idiopathic central serous chorioretinopathy. (15088832)
2004
42
Optical coherence tomographic findings in pregnancy-associated central serous chorioretinopathy. (15490217)
2004
43
Effect of catecholamine on central serous chorioretinopathy. (14526445)
2003
44
Perfluorocarbon liquid-assisted external drainage in the management of central serous chorioretinopathy with bullous serous retinal detachment. (14717214)
2003
45
Central serous chorioretinopathy associated with administration of sympathomimetic agents. (12834690)
2003
46
Factors associated with reduced visual acuity during long-term follow-up of patients with idiopathic central serous chorioretinopathy. (11884873)
2002
47
Involvement of corticosteroids and catecholamines in the pathogenesis of central serous chorioretinopathy: a rationale for new treatment strategies. (12359592)
2002
48
Idiopathic central serous chorioretinopathy--a physical complication of stress? (11307690)
2001
49
Central serous chorioretinopathy after bone marrow transplantation. (11384585)
2001
50
Systemic findings associated with central serous chorioretinopathy. (10482095)
1999

Genetic Variations for Central Serous Chorioretinopathy

Expression for genes affiliated with Central Serous Chorioretinopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Central Serous Chorioretinopathy

Search GEO for disease gene expression data for Central Serous Chorioretinopathy.

Pathways for genes affiliated with Central Serous Chorioretinopathy

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 53R&D Systems, 30KEGG
See all sources

Pathways related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SERPINE1, PLAT
2
Translation Insulin regulation of translation
Hide members
9.1SERPINE1, PLAT
3
Cell adhesion ECM remodeling
Hide members
9.1SERPINE1, PLAT
49.1PLAT, SERPINE1
5
Hide members
9.1SERPINE1, PLAT
6
Hide members
9.1SERPINE1, PLAT
79.1SERPINE1, PLAT

Compounds for genes affiliated with Central Serous Chorioretinopathy

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1notoginsenoside r1459.6SERPINE1, PLAT
2batroxobin459.6PLAT, SERPINE1
3eaca459.6PLAT, SERPINE1
4p-amino benzamidine459.6SERPINE1, PLAT
5ancrod459.6SERPINE1, PLAT
6Urokinase119.6PLAT, SERPINE1
7chloramine t459.5SERPINE1, PLAT
8quinapril45 1110.5SERPINE1, PLAT
9tranexamic acid45 1110.5SERPINE1, PLAT
10epsilon aminocaproic acid459.5PLAT, SERPINE1
11perindopril45 50 1111.5PLAT, SERPINE1
12fucoidan459.5SERPINE1, PLAT
13hydrochlorothiazide45 50 29 11 2413.5PLAT, SERPINE1
14enalapril45 50 1111.5SERPINE1, PLAT
15diisopropylfluorophosphate459.5SERPINE1, PLAT
16gemfibrozil45 29 1111.5PLAT, SERPINE1
17desmopressin45 60 29 1112.5SERPINE1, PLAT
18hirudin459.5SERPINE1, PLAT
19p005459.5PLAT, SERPINE1
20protamine459.5SERPINE1, PLAT
21fluvastatin45 50 29 1112.5SERPINE1, PLAT
22kininogen459.5PLAT, SERPINE1
23losartan45 50 29 1112.5SERPINE1, PLAT
24pge1459.5SERPINE1, PLAT
25aprotinin45 1110.5PLAT, SERPINE1
26p003459.5SERPINE1, PLAT
27homocysteine45 2410.4PLAT, SERPINE1
28sodium nitroprusside459.4PLAT, SERPINE1
29atorvastatin45 50 29 11 2413.4SERPINE1, PLAT
30troglitazone45 29 60 1112.4PLAT, SERPINE1
315-hydroxytryptamine459.4SERPINE1, PLAT
32simvastatin45 50 60 29 11 2414.4SERPINE1, PLAT
33heparan sulfate45 2410.4PLAT, SERPINE1
34isoproterenol45 1110.4SERPINE1, PLAT
35prostacyclin459.3PLAT, SERPINE1
36nicotine45 50 29 1112.3PLAT, SERPINE1
37aspirin45 50 29 2412.3SERPINE1, PLAT
38gnrh459.2PLAT, SERPINE1
39chloramphenicol45 2 1111.2SERPINE1, PLAT
40matrigel459.1SERPINE1, PLAT
41estradiol45 11 2411.1SERPINE1, PLAT
42fibrinogen459.0PLAT, SERPINE1
43actinomycin d458.8SERPINE1, PLAT

GO Terms for genes affiliated with Central Serous Chorioretinopathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1SERPINE1, PLAT

Biological processes related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.1SERPINE1, PLAT

Products for genes affiliated with Central Serous Chorioretinopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Serous Chorioretinopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet