MCID: CNT060
MIFTS: 41

Central Serous Chorioretinopathy malady

Rare diseases, Bone diseases, Immune diseases categories

Summaries for Central Serous Chorioretinopathy

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Central serous chorioretinopathy is a disease that causes fluid to build up under the retina, the back part of the inner eye that sends sight information to the brain. the fluid leaks from the choroid (the blood vessel layer under the retina). the cause of this condition is unknown but stress can be a risk factor. signs and symptoms include dim and blurred blind spot in the center of vision, distortion of straight lines and seeing objects as smaller or farther away. many cases of central serous chorioretinopathy improve without treatment after 1-2 months. laser treatment may be an option for other individuals. last updated: 1/30/2014

MalaCards: Central Serous Chorioretinopathy, also known as central serous chorioretinopathy after bone marrow transplantation, is related to hypertension and retinitis. An important gene associated with Central Serous Chorioretinopathy is SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), and among its related pathways are Senescence and Autophagy and Translation Insulin regulation of translation. The compounds notoginsenoside r1 and batroxobin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone.

Wikipedia:66 Central serous retinopathy (CSR), also known as central serous chorioretinopathy (CSC), is an eye... more...

Aliases & Classifications for Central Serous Chorioretinopathy

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Immune diseases


Aliases & Descriptions:

central serous chorioretinopathy 44 63
central serous chorioretinopathy after bone marrow transplantation 44
central serous choroidopathy 44


Related Diseases for Central Serous Chorioretinopathy

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Central Serous Chorioretinopathy:



Diseases related to central serous chorioretinopathy

Symptoms for Central Serous Chorioretinopathy

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Drugs & Therapeutics for Central Serous Chorioretinopathy

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Serous Chorioretinopathy

Drug clinical trials:

Search ClinicalTrials for Central Serous Chorioretinopathy

Search NIH Clinical Center for Central Serous Chorioretinopathy

Search CenterWatch for Central Serous Chorioretinopathy

Genetic Tests for Central Serous Chorioretinopathy

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Anatomical Context for Central Serous Chorioretinopathy

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34MalaCards
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MalaCards organs/tissues related to Central Serous Chorioretinopathy:

34
Eye, Retina, Bone, Bone marrow, Brain, Endothelial, Cortex, B cells, Heart, Testes, Adrenal cortex

Animal Models for Central Serous Chorioretinopathy or affiliated genes

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Publications for Central Serous Chorioretinopathy

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53PubMed
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Articles related to Central Serous Chorioretinopathy:

(show top 50)    (show all 486)
idTitleAuthorsYear
1
Assessment of choroidal topographic changes by swept source optical coherence tomography after photodynamic therapy for central serous chorioretinopathy. (24412124)
2014
2
Current concepts in managing central serous chorioretinopathy. (24392907)
2014
3
Effects of smoking on visual acuity of central serous chorioretinopathy patients. (23841829)
2013
4
Getting serious with retinopathy: approaching an integrated hypothesis for central serous chorioretinopathy. (23669373)
2013
5
Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography. (24171107)
2013
6
Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy. (24365176)
2013
7
Central serous chorioretinopathy due to tadalafil use. (23065016)
2013
8
Cushing disease revealed by bilateral atypical central serous chorioretinopathy: case report. (24013974)
2013
9
New guidelines in the treatment of persistent central serous chorioretinopathy: PDT with half-dose verteporfin. (22495997)
2012
10
Central serous chorioretinopathy after blunt trauma. (22669212)
2012
11
Correlation of spectral domain optical coherence tomography findings in acute central serous chorioretinopathy with visual acuity. (23225998)
2012
12
Correlations among various functional and morphological tests in resolved central serous chorioretinopathy. (21617156)
2012
13
Central serous chorioretinopathy in myopic patients. (23044956)
2012
14
Intravitreal bevacizumab for choroidal neovascularization secondary to laser photocoagulation for central serous chorioretinopathy. (21928270)
2012
15
Improvement in multifocal electroretinography after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy: a randomized placebo-controlled trial. (21836413)
2011
16
Persistent subretinal fluid due to central serous chorioretinopathy after retinal detachment surgery. (22069347)
2011
17
Central serous chorioretinopathy mistaken for tuberculous choroiditis. (22454755)
2011
18
Review and update of central serous chorioretinopathy. (21427570)
2011
19
Bilateral central serous chorioretinopathy resolving rapidly with treatment for obstructive sleep apnea. (20049474)
2010
20
Cirrus HD-OCT high definition imaging is another tool available for visualization of the choroid and provides agreement with the finding that the choroidal thickness is increased in central serous chorioretinopathy in comparison to normal eyes. (20827146)
2010
21
Intravitreal bevacizumab injection for central serous chorioretinopathy. (20010322)
2010
22
Retinal thickness and perimetric sensitivity in central serous chorioretinopathy. (21191719)
2010
23
Correlation of retinal sensitivity and retinal thickness in central serous chorioretinopathy. (19684422)
2010
24
Intravitreal Bevacizumab for the Treatment of Central Serous Chorioretinopathy. (20429499)
2010
25
Central serous chorioretinopathy resulting in altered vision and color perception after glenohumeral corticosteroid injection. (19708628)
2009
26
Photodynamic therapy for chronic pigment epithelial detachment in central serous chorioretinopathy. (19491970)
2009
27
The optical coherence tomography-ophthalmoscope for examination of central serous chorioretinopathy with precipitates. (18536604)
2008
28
Photodynamic therapy as treatment of chronic idiopathic central serous chorioretinopathy. (19065564)
2008
29
Obstructive sleep apnea in patients with central serous chorioretinopathy. (18546012)
2008
30
Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy. (16936642)
2008
31
Elongation of photoreceptor outer segment in central serous chorioretinopathy. (18028861)
2008
32
Successful outcome of giant retinal pigment epithelium rip in idiopathic central serous chorioretinopathy. (18301045)
2008
33
The value of contrast sensitivity in diagnosing central serous chorioretinopathy. (17535369)
2007
34
Selective retina therapy in patients with central serous chorioretinopathy. (16758179)
2006
35
Safety enhanced photodynamic therapy with half dose verteporfin for chronic central serous chorioretinopathy: a short term pilot study. (16597666)
2006
36
Current and future role of photodynamic therapy in chronic central serous chorioretinopathy. (15734027)
2005
37
Central serous chorioretinopathy and glucocorticoids. (14711450)
2004
38
Indocyanine green dye-enhanced micropulsed diode laser: a novel approach to subthreshold RPE treatment in a case of central serous chorioretinopathy. (15005592)
2004
39
Effect of catecholamine on central serous chorioretinopathy. (14526445)
2003
40
Cystoid macular degeneration in chronic central serous chorioretinopathy. (12652224)
2003
41
Central serous chorioretinopathy. (12770954)
2003
42
Central serous chorioretinopathy associated with adrenal myelolipoma. (12664380)
2003
43
Indocyanine green-mediated photothrombosis as a new technique of treatment for persistent central serous chorioretinopathy. (12658548)
2002
44
Long-term follow-up of idiopathic central serous chorioretinopathy without laser. (11453866)
2001
45
Surgical management of exudative retinal detachment associated with central serous chorioretinopathy. (11125275)
2001
46
Retinal pigment epithelial tears associated with idiopathic central serous chorioretinopathy. (11340893)
2000
47
Polypoidal choroidal vasculopathy masquerading as central serous chorioretinopathy. (10768341)
2000
48
Bullous variant of idiopathic central serous chorioretinopathy. (10781512)
2000
49
Central serous chorioretinopathy complicated by massive bilateral subretinal haemorrhage. (10906108)
2000
50
Central serous chorioretinopathy complicating solar retinopathy treated with glucocorticoids. (9987635)
1999

Variations for Central Serous Chorioretinopathy

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Expression for genes affiliated with Central Serous Chorioretinopathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Serous Chorioretinopathy

Search GEO for disease gene expression data for Central Serous Chorioretinopathy.

Pathways for genes affiliated with Central Serous Chorioretinopathy

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome, 13EMD Millipore, 54QIAGEN, 55R&D Systems
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Pathways related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1PLAT, SERPINE1
2
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
9.1PLAT, SERPINE1
3
Show member pathways
9.1PLAT, SERPINE1
4
Show member pathways
9.1SERPINE1, PLAT
5
Show member pathways
thioredoxin pathway39
9.1PLAT, SERPINE1
6
Show member pathways
9.1PLAT, SERPINE1
7
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.1PLAT, SERPINE1
89.1PLAT, SERPINE1

Compounds for genes affiliated with Central Serous Chorioretinopathy

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1notoginsenoside r1469.6PLAT, SERPINE1
2batroxobin469.6PLAT, SERPINE1
3eaca469.6PLAT, SERPINE1
4p-amino benzamidine469.6SERPINE1, PLAT
5ancrod469.6SERPINE1, PLAT
6chloramine t469.6PLAT, SERPINE1
7quinapril46 52 1211.6SERPINE1, PLAT
8tranexamic acid46 1210.6PLAT, SERPINE1
9epsilon aminocaproic acid469.6SERPINE1, PLAT
10perindopril46 52 1211.6SERPINE1, PLAT
11fucoidan469.6PLAT, SERPINE1
12hydrochlorothiazide46 30 52 25 1213.6PLAT, SERPINE1
13enalapril46 52 1211.5SERPINE1, PLAT
14diisopropylfluorophosphate469.5PLAT, SERPINE1
15gemfibrozil30 46 1211.5PLAT, SERPINE1
16desmopressin46 62 30 1212.5SERPINE1, PLAT
17hirudin469.5PLAT, SERPINE1
18p005469.5PLAT, SERPINE1
19protamine469.5SERPINE1, PLAT
20kininogen469.5PLAT, SERPINE1
21fluvastatin46 52 30 1212.5PLAT, SERPINE1
22losartan46 52 30 1212.5SERPINE1, PLAT
23pge1469.5PLAT, SERPINE1
24aprotinin46 1210.5PLAT, SERPINE1
25p003469.5SERPINE1, PLAT
26sodium nitroprusside469.5PLAT, SERPINE1
27homocysteine46 2510.5PLAT, SERPINE1
28atorvastatin46 52 30 25 1213.5SERPINE1, PLAT
29troglitazone46 30 62 1212.5PLAT, SERPINE1
305-hydroxytryptamine469.5PLAT, SERPINE1
31simvastatin46 52 62 30 25 1214.5SERPINE1, PLAT
32heparan sulfate46 2510.5PLAT, SERPINE1
33isoproterenol46 1210.4PLAT, SERPINE1
34prostacyclin469.4SERPINE1, PLAT
35nicotine46 30 52 1212.4PLAT, SERPINE1
36aspirin46 52 30 2512.4PLAT, SERPINE1
37gnrh469.4SERPINE1, PLAT
38chloramphenicol46 3 52 1212.4PLAT, SERPINE1
39matrigel469.4PLAT, SERPINE1
40fibrinogen469.4SERPINE1, PLAT
41actinomycin d469.3PLAT, SERPINE1
42estradiol46 25 1211.3PLAT, SERPINE1
43creatinine469.3SERPINE1, PLAT
44aspartate469.2PLAT, SERPINE1
45heparin46 30 25 1212.2PLAT, SERPINE1
46adenylate469.1SERPINE1, PLAT
47cholesterol46 30 25 1212.1PLAT, SERPINE1
48cycloheximide469.0PLAT, SERPINE1
49progesterone46 30 62 25 1212.8PLAT, SERPINE1

GO Terms for genes affiliated with Central Serous Chorioretinopathy

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17Gene Ontology
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Cellular components related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1PLAT, SERPINE1

Biological processes related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1PLAT, SERPINE1
2fibrinolysisGO:0427308.8PLAT, SERPINE1

Products for genes affiliated with Central Serous Chorioretinopathy

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  • Antibodies
  • Proteins
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Sources for Central Serous Chorioretinopathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet