MCID: CNT060
MIFTS: 41

Central Serous Chorioretinopathy malady

Rare diseases, Bone diseases, Immune diseases categories
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Summaries for Central Serous Chorioretinopathy

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Central serous chorioretinopathy is a disease that causes fluid to build up under the retina, the back part of the inner eye that sends sight information to the brain. the fluid leaks from the choroid (the blood vessel layer under the retina). the cause of this condition is unknown but stress can be a risk factor. signs and symptoms include dim and blurred blind spot in the center of vision, distortion of straight lines and seeing objects as smaller or farther away. many cases of central serous chorioretinopathy improve without treatment after 1-2 months. laser treatment may be an option for other individuals. last updated: 1/30/2014

MalaCards: Central Serous Chorioretinopathy, also known as central serous chorioretinopathy after bone marrow transplantation, is related to hypertension and retinitis. An important gene associated with Central Serous Chorioretinopathy is SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), and among its related pathways are Senescence and Autophagy and Translation Insulin regulation of translation. The compounds notoginsenoside r1 and batroxobin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone.

Wikipedia:65 Central serous retinopathy (CSR), also known as central serous chorioretinopathy (CSC), is an eye... more...

Aliases & Classifications for Central Serous Chorioretinopathy

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Immune diseases


Aliases & Descriptions:

central serous chorioretinopathy 43 62
central serous chorioretinopathy after bone marrow transplantation 43
central serous choroidopathy 43


Related Diseases for Central Serous Chorioretinopathy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Central Serous Chorioretinopathy:



Diseases related to central serous chorioretinopathy

Symptoms for Central Serous Chorioretinopathy

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Drugs & Therapeutics for Central Serous Chorioretinopathy

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Central Serous Chorioretinopathy

Search NIH Clinical Center for Central Serous Chorioretinopathy

Genetic Tests for Central Serous Chorioretinopathy

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Anatomical Context for Central Serous Chorioretinopathy

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33MalaCards
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MalaCards organs/tissues related to Central Serous Chorioretinopathy:

33
Eye, Retina, Bone, Bone marrow, Brain, Endothelial, Cortex, B cells, Heart, Testes, Adrenal cortex

Animal Models for Central Serous Chorioretinopathy or affiliated genes

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Publications for Central Serous Chorioretinopathy

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52PubMed
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Articles related to Central Serous Chorioretinopathy:

(show top 50)    (show all 486)
idTitleAuthorsYear
1
Assessment of choroidal topographic changes by swept source optical coherence tomography after photodynamic therapy for central serous chorioretinopathy. (24412124)
2014
2
Current concepts in managing central serous chorioretinopathy. (24392907)
2014
3
Effects of smoking on visual acuity of central serous chorioretinopathy patients. (23841829)
2013
4
Getting serious with retinopathy: approaching an integrated hypothesis for central serous chorioretinopathy. (23669373)
2013
5
Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography. (24171107)
2013
6
Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy. (24365176)
2013
7
Central serous chorioretinopathy due to tadalafil use. (23065016)
2013
8
Cushing disease revealed by bilateral atypical central serous chorioretinopathy: case report. (24013974)
2013
9
New guidelines in the treatment of persistent central serous chorioretinopathy: PDT with half-dose verteporfin. (22495997)
2012
10
Central serous chorioretinopathy after blunt trauma. (22669212)
2012
11
Correlation of spectral domain optical coherence tomography findings in acute central serous chorioretinopathy with visual acuity. (23225998)
2012
12
Correlations among various functional and morphological tests in resolved central serous chorioretinopathy. (21617156)
2012
13
Central serous chorioretinopathy in myopic patients. (23044956)
2012
14
Intravitreal bevacizumab for choroidal neovascularization secondary to laser photocoagulation for central serous chorioretinopathy. (21928270)
2012
15
Improvement in multifocal electroretinography after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy: a randomized placebo-controlled trial. (21836413)
2011
16
Persistent subretinal fluid due to central serous chorioretinopathy after retinal detachment surgery. (22069347)
2011
17
Central serous chorioretinopathy mistaken for tuberculous choroiditis. (22454755)
2011
18
Review and update of central serous chorioretinopathy. (21427570)
2011
19
Bilateral central serous chorioretinopathy resolving rapidly with treatment for obstructive sleep apnea. (20049474)
2010
20
Cirrus HD-OCT high definition imaging is another tool available for visualization of the choroid and provides agreement with the finding that the choroidal thickness is increased in central serous chorioretinopathy in comparison to normal eyes. (20827146)
2010
21
Intravitreal bevacizumab injection for central serous chorioretinopathy. (20010322)
2010
22
Retinal thickness and perimetric sensitivity in central serous chorioretinopathy. (21191719)
2010
23
Correlation of retinal sensitivity and retinal thickness in central serous chorioretinopathy. (19684422)
2010
24
Intravitreal Bevacizumab for the Treatment of Central Serous Chorioretinopathy. (20429499)
2010
25
Central serous chorioretinopathy resulting in altered vision and color perception after glenohumeral corticosteroid injection. (19708628)
2009
26
Photodynamic therapy for chronic pigment epithelial detachment in central serous chorioretinopathy. (19491970)
2009
27
The optical coherence tomography-ophthalmoscope for examination of central serous chorioretinopathy with precipitates. (18536604)
2008
28
Photodynamic therapy as treatment of chronic idiopathic central serous chorioretinopathy. (19065564)
2008
29
Obstructive sleep apnea in patients with central serous chorioretinopathy. (18546012)
2008
30
Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy. (16936642)
2008
31
Elongation of photoreceptor outer segment in central serous chorioretinopathy. (18028861)
2008
32
Successful outcome of giant retinal pigment epithelium rip in idiopathic central serous chorioretinopathy. (18301045)
2008
33
The value of contrast sensitivity in diagnosing central serous chorioretinopathy. (17535369)
2007
34
Selective retina therapy in patients with central serous chorioretinopathy. (16758179)
2006
35
Safety enhanced photodynamic therapy with half dose verteporfin for chronic central serous chorioretinopathy: a short term pilot study. (16597666)
2006
36
Current and future role of photodynamic therapy in chronic central serous chorioretinopathy. (15734027)
2005
37
Central serous chorioretinopathy and glucocorticoids. (14711450)
2004
38
Indocyanine green dye-enhanced micropulsed diode laser: a novel approach to subthreshold RPE treatment in a case of central serous chorioretinopathy. (15005592)
2004
39
Effect of catecholamine on central serous chorioretinopathy. (14526445)
2003
40
Cystoid macular degeneration in chronic central serous chorioretinopathy. (12652224)
2003
41
Central serous chorioretinopathy. (12770954)
2003
42
Central serous chorioretinopathy associated with adrenal myelolipoma. (12664380)
2003
43
Indocyanine green-mediated photothrombosis as a new technique of treatment for persistent central serous chorioretinopathy. (12658548)
2002
44
Long-term follow-up of idiopathic central serous chorioretinopathy without laser. (11453866)
2001
45
Surgical management of exudative retinal detachment associated with central serous chorioretinopathy. (11125275)
2001
46
Retinal pigment epithelial tears associated with idiopathic central serous chorioretinopathy. (11340893)
2000
47
Polypoidal choroidal vasculopathy masquerading as central serous chorioretinopathy. (10768341)
2000
48
Bullous variant of idiopathic central serous chorioretinopathy. (10781512)
2000
49
Central serous chorioretinopathy complicated by massive bilateral subretinal haemorrhage. (10906108)
2000
50
Central serous chorioretinopathy complicating solar retinopathy treated with glucocorticoids. (9987635)
1999

Variations for Central Serous Chorioretinopathy

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Expression for genes affiliated with Central Serous Chorioretinopathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Serous Chorioretinopathy

Search GEO for disease gene expression data for Central Serous Chorioretinopathy.

Pathways for genes affiliated with Central Serous Chorioretinopathy

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG, 55Reactome, 12EMD Millipore, 53QIAGEN, 54R&D Systems
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Pathways related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1PLAT, SERPINE1
2
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1PLAT, SERPINE1
3
Show member pathways
9.1PLAT, SERPINE1
4
Show member pathways
9.1SERPINE1, PLAT
5
Show member pathways
thioredoxin pathway38
9.1PLAT, SERPINE1
6
Show member pathways
9.1PLAT, SERPINE1
7
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.1PLAT, SERPINE1
89.1PLAT, SERPINE1

Compounds for genes affiliated with Central Serous Chorioretinopathy

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1notoginsenoside r1459.6PLAT, SERPINE1
2batroxobin459.6PLAT, SERPINE1
3eaca459.6PLAT, SERPINE1
4p-amino benzamidine459.6SERPINE1, PLAT
5ancrod459.6SERPINE1, PLAT
6chloramine t459.6PLAT, SERPINE1
7quinapril45 51 1111.6SERPINE1, PLAT
8tranexamic acid45 1110.6PLAT, SERPINE1
9epsilon aminocaproic acid459.6SERPINE1, PLAT
10perindopril45 51 1111.6SERPINE1, PLAT
11fucoidan459.6PLAT, SERPINE1
12hydrochlorothiazide45 29 51 24 1113.6PLAT, SERPINE1
13enalapril45 51 1111.5SERPINE1, PLAT
14diisopropylfluorophosphate459.5PLAT, SERPINE1
15gemfibrozil29 45 1111.5PLAT, SERPINE1
16desmopressin45 61 29 1112.5SERPINE1, PLAT
17hirudin459.5PLAT, SERPINE1
18p005459.5PLAT, SERPINE1
19protamine459.5SERPINE1, PLAT
20kininogen459.5PLAT, SERPINE1
21fluvastatin45 51 29 1112.5PLAT, SERPINE1
22losartan45 51 29 1112.5SERPINE1, PLAT
23pge1459.5PLAT, SERPINE1
24aprotinin45 1110.5PLAT, SERPINE1
25p003459.5SERPINE1, PLAT
26sodium nitroprusside459.5PLAT, SERPINE1
27homocysteine45 2410.5PLAT, SERPINE1
28atorvastatin45 51 29 24 1113.5SERPINE1, PLAT
29troglitazone45 29 61 1112.5PLAT, SERPINE1
305-hydroxytryptamine459.5PLAT, SERPINE1
31simvastatin45 51 61 29 24 1114.5SERPINE1, PLAT
32heparan sulfate45 2410.5PLAT, SERPINE1
33isoproterenol45 1110.4PLAT, SERPINE1
34prostacyclin459.4SERPINE1, PLAT
35nicotine45 29 51 1112.4PLAT, SERPINE1
36aspirin45 51 29 2412.4PLAT, SERPINE1
37gnrh459.4SERPINE1, PLAT
38chloramphenicol45 3 51 1112.4PLAT, SERPINE1
39matrigel459.4PLAT, SERPINE1
40fibrinogen459.4SERPINE1, PLAT
41actinomycin d459.3PLAT, SERPINE1
42estradiol45 24 1111.3PLAT, SERPINE1
43creatinine459.3SERPINE1, PLAT
44aspartate459.2PLAT, SERPINE1
45heparin45 29 24 1112.2PLAT, SERPINE1
46adenylate459.1SERPINE1, PLAT
47cholesterol45 29 24 1112.1PLAT, SERPINE1
48cycloheximide459.0PLAT, SERPINE1
49progesterone45 29 61 24 1112.8PLAT, SERPINE1

GO Terms for genes affiliated with Central Serous Chorioretinopathy

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16Gene Ontology
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Cellular components related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1PLAT, SERPINE1

Biological processes related to Central Serous Chorioretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1PLAT, SERPINE1
2fibrinolysisGO:0427308.8PLAT, SERPINE1

Products for genes affiliated with Central Serous Chorioretinopathy

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  • Antibodies
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Sources for Central Serous Chorioretinopathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet