MCID: CNT015
MIFTS: 42

Central Sleep Apnea malady

Summaries for Central Sleep Apnea

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

MalaCards: Central Sleep Apnea, also known as central sleep apnea, primary, is related to congestive heart failure and hypertension. An important gene associated with Central Sleep Apnea is NPPB (natriuretic peptide B), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Potassium transporters: inward current. The compounds p00035 and hncs have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related mouse phenotype cardiovascular system.

Disease Ontology:8 A sleep disorder involving diminished capability to breath for short periods of time.

Aliases & Classifications for Central Sleep Apnea

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

central sleep apnea 8 10
central sleep apnea, primary 60
primary central sleep apnea 8
sleep apnea, central 60


External Ids:

Disease Ontology8 DOID:9220
MeSH34 D020182
ICD9CM27 327.21

Related Diseases for Central Sleep Apnea

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Central Sleep Apnea family:

Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure31.1NPPA, NPPB
2hypertension30.5NOS3, NPPA, NPPB
3stroke, ischemic30.4NOS3, NPPA
4dilated cardiomyopathy30.4NPPA, NPPB
5heart valve disease30.2NPPB, NPPA
6primary pulmonary hypertension30.2NPPB, NPPA
7pharyngitis10.3
8systolic heart failure10.3
9hypothyroidism10.3
10idiopathic alveolar hypoventilation syndrome10.3
11carotid stenosis10.2
12hyperprolactinemia10.2
13cerebritis10.2
14acromegaly10.2
15leber hereditary optic neuropathy10.2
16diastolic heart failure10.2
17adult syndrome10.2
18joubert syndrome10.2
19cervicitis10.2
20craniosynostosis10.2
21esophagitis10.2
22leukemia10.2
23myocardial infarction10.2
24neuropathy10.2
25obesity10.2
26sleep disorder10.2
27congenital central hypoventilation syndrome10.2
28image syndrome10.2
29central nervous system teratoma10.2
30myocarditis10.0NPPB
31hepatopulmonary syndrome10.0NOS3
32thromboembolism10.0NOS3
33sick sinus syndrome10.0NPPA
34graves' disease10.0NOS3
35hyperaldosteronism10.0NPPA
36pulmonary embolism10.0NPPB
37mitral valve insufficiency10.0NPPB, NPPA
38mitral valve stenosis10.0NPPB, NPPA
39syndrome of inappropriate antidiuretic hormone10.0NPPB, NPPA
40idiopathic edema10.0NPPB, NPPA
41aortic valve stenosis10.0NPPB, NPPA
42hypertensive heart disease10.0NPPA, NPPB
43cor pulmonale10.0NPPA, NPPB
44congenital heart defect10.0NPPA, NPPB
45acute myocardial infarction10.0NPPA, NPPB
46liver cirrhosis10.0NPPA, NOS3
47ischemic heart disease10.0NPPB, NPPA, NOS3
48coronary artery disease10.0NPPB, NPPA, NOS3
49chronic kidney failure10.0NPPB, NPPA, NOS3
50coronary heart disease10.0NOS3, NPPB

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to central sleep apnea

Clinical Features for Central Sleep Apnea

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Drugs & Therapeutics for Central Sleep Apnea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Sleep Apnea

Drug clinical trials:

Search ClinicalTrials for Central Sleep Apnea

Search NIH Clinical Center for Central Sleep Apnea

Search CenterWatch for Central Sleep Apnea

Genetic Tests for Central Sleep Apnea

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Anatomical Context for Central Sleep Apnea

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32MalaCards
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MalaCards organs/tissues related to Central Sleep Apnea:

32
Heart, Brain, Testes, Tongue

Animal Models for Central Sleep Apnea or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Central Sleep Apnea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.3NOTO, NOS3, NPPA, NPPB, KCNK3, KCNK9

Publications for Central Sleep Apnea

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50PubMed
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Articles related to Central Sleep Apnea:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Central sleep apnea in obese children with sleep-disordered breathing. (24048143)
2014
2
Surgical cure of central sleep apnea? (23905527)
2013
3
Contrasting effects of lower body positive pressure on upper airways resistance and partial pressure of carbon dioxide in men with heart failure and obstructive or central sleep apnea. (23375931)
2013
4
Randomized controlled trial of noninvasive positive pressure ventilation (NPPV) versus servoventilation in patients with CPAP-induced central sleep apnea (complex sleep apnea). (23904676)
2013
5
Central sleep apnea: effects on stroke volume in heart failure. (23418326)
2013
6
Pearls & oy-sters: treatment of central sleep apnea with topiramate. (22508854)
2012
7
Treatment of central sleep apnea in U.S. veterans. (23066368)
2012
8
Central sleep apnea is a predictor of cardiac readmission in hospitalized patients with systolic heart failure. (22748486)
2012
9
Reversal of central sleep apnea following discontinuation of opioids. (23066372)
2012
10
A novel approach to the treatment of central sleep apnea in patients with heart failure. (22351150)
2012
11
Effectiveness of Adaptive Servo Ventilation in the treatment of hypocapnic central sleep apnea of various etiologies. (22030207)
2011
12
Central sleep apnea detection and stimulation. (22256104)
2011
13
Sleep apnea syndrome: central sleep apnea and pulmonary hypertension worsened during treatment with auto-CPAP, but improved by adaptive servo-ventilation. (20190475)
2010
14
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
15
Postoperative pain relief with ketamine in patients with central sleep apnea. (19961036)
2009
16
Effectiveness of nocturnal home oxygen therapy to improve exercise capacity, cardiac function and cardiac sympathetic nerve activity in patients with chronic heart failure and central sleep apnea. (19122308)
2009
17
Opioid-associated central sleep apnea: a case series. (18807080)
2009
18
Obstructive sleep apnea in patients with central serous chorioretinopathy. (18546012)
2008
19
Influence of thermal drive on central sleep apnea in the preterm neonate. (18457243)
2008
20
Prevalence and management of central sleep apnea in heart failure patients. (19032919)
2008
21
Central sleep apnea and Cheyne-Stokes respiration. (18250216)
2008
22
Catathrenia: a rare parasomnia which may mimic central sleep apnea on polysomnogram. (18086548)
2008
23
Treating central sleep apnea in heart failure: outcomes revisited. (17592088)
2007
24
Sleep disturbances in 22q11.2 deletion syndrome: a case with obstructive and central sleep apnea. (17477750)
2007
25
CPAP should not be used for central sleep apnea in congestive heart failure patients. (17557466)
2006
26
Severe hypersomnolence associated with periodic limb movements and central sleep apnea in a cocaine addicted HIV patient. (16458599)
2006
27
First experience of using new adaptive servo-ventilation device for Cheyne-Stokes respiration with central sleep apnea among Japanese patients with congestive heart failure: report of 4 clinical cases. (16936427)
2006
28
Efficacy of nasal bi-level positive airway pressure in congestive heart failure patients with cheyne-stokes respiration and central sleep apnea. (16041159)
2005
29
Pathogenesis of obstructive and central sleep apnea. (16100008)
2005
30
Central sleep apnea in congestive heart failure: prevalence, mechanisms, impact, and therapeutic options. (16052417)
2005
31
Improvement of cheyne-stokes respiration, central sleep apnea and congestive heart failure by noninvasive bilevel positive pressure and medical treatment. (15329513)
2004
32
The effect of successful heart transplant treatment of heart failure on central sleep apnea. (14605034)
2003
33
Crossing the threshold: implications for central sleep apnea. (11991865)
2002
34
A case of diabetes, deafness, cardiomyopathy, and central sleep apnea: novel mitochondrial DNA polymorphisms. (12002277)
2002
35
Acetazolamide treatment for infantile central sleep apnea. (11510934)
2001
36
Primary pulmonary hypertension with central sleep apnea: sudden death after bilevel positive airway pressure therapy. (10981861)
2000
37
Central sleep apnea (9838017)
1998
38
"Dephlogisticated air" revisited. Oxygen treatment for central sleep apnea syndrome. (9041966)
1997
39
Reversal of central sleep apnea with oxygen. (8996011)
1997
40
Central sleep apnea-hypopnea syndrome in heart failure: prevalence, impact, and treatment. (9085518)
1996
41
Central sleep apnea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patients with acromegaly. (8049836)
1994
42
Evaluation of an aviator with chronic disequilibrium, oscillopsia, and central sleep apnea. (8185560)
1994
43
Central sleep apnea. (1521415)
1992
44
Central sleep apnea and partial obstruction of the upper airway. (3296946)
1987
45
Radiation necrosis causing failure of automatic ventilation during sleep with central sleep apnea. (3622038)
1987
46
Post-traumatic central sleep apnea in a child. (3295161)
1987
47
Clinical and physiologic heterogeneity of the central sleep apnea syndrome. (3740646)
1986
48
Recurrent hypothermia, hypersomnolence, central sleep apnea, hypodipsia, hypernatremia, hypothyroidism, hyperprolactinemia and growth hormone deficiency in a boy--treatment with clomipramine. (3465179)
1986
49
Reversal of central sleep apnea using nasal CPAP. (3525020)
1986
50
Trichloroethane (TCE) and central sleep apnea: a case study. (6827617)
1983

Genetic Variations for Central Sleep Apnea

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Expression for genes affiliated with Central Sleep Apnea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for genes affiliated with Central Sleep Apnea

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Sources:
51QIAGEN, 12EMD Millipore, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Central Sleep Apnea

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Central Sleep Apnea according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1p000354410.1NPPB, NPPA
2hncs4410.1NPPB, NPPA
3candoxatril44 1111.1NPPB, NPPA
4alacepril4410.1NPPB, NPPA
5imidapril4410.1NPPA, NPPB
6urodilatin4410.0NPPB, NPPA
7trandolapril44 1111.0NPPB, NPPA
8bisoprolol44 49 1112.0NPPB, NPPA
9hanp4410.0NPPB, NPPA
10dobutamine44 28 1112.0NPPB, NPPA
11fosinopril44 1111.0NPPA, NPPB
12moxonidine4410.0NPPA, NPPB
13celiprolol4410.0NPPB, NOS3
14enalaprilat4410.0NPPA, NPPB
15lisinopril44 11 2412.0NPPB, NPPA
16nppb44 59 2811.9NPPB, NPPA
17mibg449.9NPPA, NPPB
18ramipril44 1110.9NPPA, NPPB
19isosorbide dinitrate44 49 1111.9NOS3, NPPA
20papaverine44 2 1111.9NPPB, NOS3
218-bromo cgmp449.8NPPB, NPPA
22kt 582344 2810.7NPPA, NOS3
23enalapril44 49 1111.7NPPA, NPPB
24candesartan44 28 1111.7NOS3, NPPB
25Doxapram119.7KCNK9, KCNK3
26spironolactone49 44 59 28 1113.6NPPB, NPPA
27ng-nitro-l-arginine449.6NOS3, NPPA
28spec-t449.6NPPA, NPPB
29dmp 543599.6KCNK9, KCNK3
30ys-035 hydrochloride599.6KCNK9, KCNK3
31metoprolol44 28 49 11 2413.6NOS3, NPPA, NPPB
32perindopril44 49 1111.6NOS3, NPPA, NPPB
33bl 1249599.6KCNK9, KCNK3
34amlodipine44 49 11 2412.6NPPB, NPPA, NOS3
35carvedilol44 49 28 1112.6NOS3, NPPA, NPPB
36sildenafil44 49 28 11 2413.6NPPB, NPPA, NOS3
37tetraethylammonium chloride599.6KCNK9, KCNK3
38s-nitroso-n-acetylpenicillamine449.6NOS3, NPPA, NPPB
39nitroglycerin44 1110.6NOS3, NPPA, NPPB
40ang ii449.6NPPB, NPPA, NOS3
41l-nmma449.5NOS3, NPPA, NPPB
42phosphoramidon44 1110.5NPPA, NPPB
43phenylephrine44 28 11 2412.5NOS3, NPPA, NPPB
44sodium nitroprusside449.5NOS3, NPPA, NPPB
45guanylate449.5NPPB, NPPA, NOS3
46cesium chloride44 5910.5KCNK9, KCNK3
47cgmp44 2810.5NPPB, NPPA, NOS3
48prostacyclin449.4NOS3, NPPA, NPPB
49allopurinol44 49 1111.3NOS3, NPPB
50arginine448.5KCNK3, NPPB, NPPA, NOS3

GO Terms for genes affiliated with Central Sleep Apnea

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16Gene Ontology
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Biological processes related to Central Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:0061829.5NPPB, NPPA
2receptor guanylyl cyclase signaling pathwayGO:0071689.3NPPA, NPPB
3cochlea developmentGO:0901029.2KCNK3, KCNK9
4regulation of blood vessel sizeGO:0508809.2NOS3, NPPA, NPPB
5regulation of blood pressureGO:0082179.1NOS3, NPPA, NPPB

Molecular functions related to Central Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel activityGO:0052679.2KCNK3, KCNK9

Products for genes affiliated with Central Sleep Apnea

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  • Antibodies
  • Proteins
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Sources for Central Sleep Apnea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet