Aliases & Classifications for Central Sleep Apnea

MalaCards integrated aliases for Central Sleep Apnea:

Name: Central Sleep Apnea 12 14
Central Sleep Apnea Syndrome 12 69
Sleep Apnea, Central 41 69
Central Sleep Apnea, Primary 69
Primary Central Sleep Apnea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9220
ICD10 32 G47.31
ICD9CM 34 327.21
MeSH 41 D020182
SNOMED-CT 64 9741000119101

Summaries for Central Sleep Apnea

Disease Ontology : 12 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary : Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and systolic heart failure, and has symptoms including apnea An important gene associated with Central Sleep Apnea is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Prolactin Signaling Pathway and AGE/RAGE pathway. The drugs Olanzapine and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and tongue.

Wikipedia : 72 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Related Diseases for Central Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 32.3 LEP NOS3 NPPB
2 systolic heart failure 30.4 HSPB7 NPPB
3 dilated cardiomyopathy 29.4 HSPB7 NOS3 NPPA NPPB
4 pulmonary hypertension 29.4 KCNK3 NOS3 NPPA NPPB
5 idiopathic alveolar hypoventilation syndrome 11.4
6 congestive heart failure 10.4
7 anterolateral myocardial infarction 10.3 NPPA NPPB
8 syndrome of inappropriate antidiuretic hormone 10.3 NPPA NPPB
9 apnea, obstructive sleep 10.3
10 syncope 10.3 NPPA NPPB
11 mitral valve stenosis 10.3 NPPA NPPB
12 idiopathic edema 10.3 NPPA NPPB
13 mitral valve insufficiency 10.2 NPPA NPPB
14 chronic mountain sickness 10.2 NOS3 NPPB
15 toxic myocarditis 10.2 NOS3 NPPB
16 renal artery disease 10.2 NOS3 NPPA
17 pericardial effusion 10.2 NPPA NPPB
18 vasculogenic impotence 10.2 NOS3 NPPA
19 diastolic heart failure 10.2 NOS3 NPPB
20 ischemic heart disease 10.2 NOS3 NPPB
21 atrial fibrillation 10.1
22 heart disease 10.1
23 renovascular hypertension 10.1 NOS3 NPPA
24 bulimia nervosa 1 10.1 LEP NPPB
25 cerebritis 10.1
26 chiari malformation 10.1
27 mitral valve disease 10.0 NOS3 NPPA
28 chronic kidney failure 10.0
29 kidney disease 10.0
30 hypoplastic left heart syndrome 10.0 LEP NPPA NPPB
31 pulmonary edema 10.0 NOS3 NPPB
32 aortic valve disease 2 10.0 NPPA NPPB
33 muscle hypertrophy 10.0 LEP NPPA
34 carotid artery occlusion 10.0 CA1 NOS3
35 coronary artery anomaly 9.9 NOS3 NPPA NPPB
36 stiff-person syndrome 9.9
37 episodic pain syndrome, familial, 1 9.9
38 hyperekplexia 1 9.9
39 hypothyroidism 9.9
40 pharyngitis 9.9
41 cervicitis 9.9
42 sleep disorder 9.9
43 streptococcal group a invasive disease 9.9
44 arteries, anomalies of 9.9 LEP NOS3 NPPB
45 apnea, central sleep 9.8
46 blood group, i system 9.8
47 multiple sclerosis 9.8
48 laryngomalacia 9.8
49 central hypoventilation syndrome, congenital 9.8
50 joubert syndrome 1 9.8

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to Central Sleep Apnea

Symptoms & Phenotypes for Central Sleep Apnea

UMLS symptoms related to Central Sleep Apnea:


apnea

Drugs & Therapeutics for Central Sleep Apnea

Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
2
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
5
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
6
Menthol Approved Phase 4 2216-51-5 16666
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
8
Zopiclone Approved Phase 4 43200-80-2 5735
9
Desflurane Approved Phase 4 57041-67-5 42113
10
Loperamide Approved Phase 4 53179-11-6 3955
11
Acetazolamide Approved, Vet_approved Phase 4,Phase 3 59-66-5 1986
12
Opium Approved, Illicit Phase 4 8008-60-4
13
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
14 tannic acid Approved, Nutraceutical Phase 4
15 Analgesics Phase 4,Phase 3,Not Applicable
16 Central Nervous System Depressants Phase 4,Phase 3,Early Phase 1
17 Narcotics Phase 4,Phase 3
18 Analgesics, Opioid Phase 4,Phase 3
19 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
20
Serotonin Phase 4,Phase 3 50-67-9 5202
21 Serotonin Agents Phase 4,Phase 3
22 Serotonin Uptake Inhibitors Phase 4,Phase 3
23 Gastrointestinal Agents Phase 4
24 Neurotransmitter Agents Phase 4,Phase 3
25 Tranquilizing Agents Phase 4,Phase 3
26 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3
27 Antidepressive Agents Phase 4,Phase 3
28 Antidepressive Agents, Second-Generation Phase 4,Phase 3
29 Antiemetics Phase 4
30 Psychotropic Drugs Phase 4,Phase 3
31 Antipsychotic Agents Phase 4
32 Autonomic Agents Phase 4
33 Adjuvants, Anesthesia Phase 4
34 Anesthetics Phase 4
35 Anesthetics, General Phase 4
36 Anesthetics, Inhalation Phase 4
37 Anesthetics, Intravenous Phase 4
38 Anti-Anxiety Agents Phase 4,Phase 3
39 Hypnotics and Sedatives Phase 4
40 Platelet Aggregation Inhibitors Phase 4
41 diuretics Phase 4,Phase 3
42 Respiratory System Agents Phase 4
43 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
44 Natriuretic Agents Phase 4,Phase 3
45 Anticonvulsants Phase 4,Phase 3
46 Antidiarrheals Phase 4
47 Carbonic Anhydrase Inhibitors Phase 4,Phase 3
48 Antitussive Agents Phase 4
49 Opium Poppy Nutraceutical Phase 4
50
Fluoxetine Approved, Vet_approved Phase 3 54910-89-3 3386

Interventional clinical trials:

(show top 50) (show all 99)

# Name Status NCT ID Phase Drugs
1 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
2 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
3 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
4 An Investigation of the Sleep Architecture and Consequent Cognitive Changes in Olanzapine-Treated Depressed Patients Completed NCT00520507 Phase 4 Olanzapine;Placebo
5 Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance Recruiting NCT02820441 Phase 4 Zopiclone;Placebo
6 Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome Recruiting NCT03031626 Phase 4
7 Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure Recruiting NCT01128816 Phase 4
8 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4 Trazodone;Placebo
9 Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome Recruiting NCT02717780 Phase 4 Fentanyl and sevoflurane;Remifentanil and desflurane
10 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Enrolling by invitation NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
11 Nocturnal Oxygen Needs and Central Sleep Apnea in Patients With Chronic Heart Failure. Not yet recruiting NCT03254212 Phase 4
12 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
13 Assessment of Desogestrel in Ondine Syndrome Completed NCT01243697 Phase 2, Phase 3 desogestrel
14 Efficacy of Fluoxetine Against Seizure-induced Central Apneas Completed NCT02569970 Phase 3 fluoxetine 20 mg;placebo 20 mg
15 Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study Completed NCT01020357 Phase 3 Caffeine citrate injection;placebo
16 Morphine in Moderate Obstructive Sleep Apnoea Recruiting NCT03127800 Phase 3 Morphine sulphate
17 Buspirone as a Potential Treatment for Recurrent Central Apnea Terminated NCT00746954 Phase 3 Acetazolamide;Buspirone
18 Dynamic Carbon Dioxide (CO2) Administration for Sleep Apnoea Unknown status NCT01041924 Phase 2
19 Chronic Evaluation of Respicardia Therapy Completed NCT01124370 Phase 2
20 Safety of Ramelteon in Subjects With Mild to Moderate Obstructive Sleep Apnea Completed NCT00672061 Phase 2 Ramelteon or Placebo
21 Stroke and CPAP Outcome Study 2 Recruiting NCT02809430 Phase 2
22 Effect of Fenofibrate on Sleep Apnea Syndrome Terminated NCT00816829 Phase 2 Placebo;Fenofibrate
23 Outcome and Treatment of Complex Sleep Apnea Withdrawn NCT01137214 Phase 2
24 Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes Respiration Unknown status NCT01212705
25 Opiate Sleep Disordered Breathing Study Unknown status NCT00791674
26 Pathophysiology of Central Apnoeas in Stroke Patients Unknown status NCT01723189
27 PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood Unknown status NCT00652964
28 Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D Unknown status NCT01733784 Not Applicable
29 Intrinsic Periodic Pattern of Breathing Unknown status NCT02201875
30 Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use Completed NCT01462084
31 PAC-IC-SAS Pilot Study - Central Sleep Apneas Syndrome and Ventricular Function Completed NCT01741337
32 The Effect of Adaptive Servo Ventilation and Oxygen Therapy in Central Sleep Apnea Patients Completed NCT01187823
33 Leg Fluid Shift in Patients With Chronic Heart Failure and Obstructive or Central Sleep Apnea Completed NCT03092388
34 BiPAP for Cardiomyopathy With Central Sleep Apnea Completed NCT00282789
35 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration Completed NCT01426776
36 Mechanisms of Action of Adaptive Servoventilation Completed NCT00976417
37 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244
38 Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175
39 Atrial Fibrillation Recurrence in Sleep Apnea Completed NCT00263757
40 Comparison of CPAP With SOMNOventCR in Patients With Underlying Heart Disease, Combined OSA and CSR Completed NCT00811668
41 Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients Completed NCT01199042
42 Nocturnal Oxygen Treatment in Heart Failure and Cheyne-Stokes Respiration Completed NCT00338078
43 Pre-operative Polysomnography Assessment of Cardiac Surgery Inpatients Completed NCT00922168
44 A Multi-Center Study to Assess the Performance of Saturation Patterns. Completed NCT00775346
45 Adaptive Servo-Ventilation in "Real Life" Conditions : the OTRLASV Study Completed NCT02429986
46 Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome in End Stage Renal Disease Patients Completed NCT01860209
47 Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry Completed NCT01500759
48 Late-onset Congenital Central Hypoventilation Syndrome and the Mutation of Phox2B Gene Completed NCT01225679
49 Validation of the Peripheral Arterial Tone to Detect Sleep-disordered Breathing in Patients With Chronic Heart Failure Completed NCT02760680
50 Validation of a New Automatic Bi-level Algorithm in the Treatment of Sleep-disordered Breathing Completed NCT00910195 Not Applicable

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

Genetic Tests for Central Sleep Apnea

Anatomical Context for Central Sleep Apnea

MalaCards organs/tissues related to Central Sleep Apnea:

38
Heart, Kidney, Tongue, Testes, Brain, Eye

Publications for Central Sleep Apnea

Articles related to Central Sleep Apnea:

(show top 50) (show all 310)
# Title Authors Year
1
Increasing cerebral blood flow reduces the severity of central sleep apnea at high altitude. ( 29389246 )
2018
2
Chiari type 1 malformation associated with central sleep apnea after high dose growth hormone (GH) therapy in a 12-year-old boy: A case report. ( 29403156 )
2018
3
Central Sleep Apnea with Cheyne-Stokes Breathing in Heart Failure - From Research to Clinical Practice and Beyond. ( 29411336 )
2018
4
Adaptive servo-ventilation and sleep quality in treatment emergent central sleep apnea and central sleep apnea in patients with heart disease and preserved ejection fraction. ( 29372314 )
2018
5
Microstructural cerebral lesions are associated with the severity of central sleep apnea with Cheyne-Stokes-respiration in heart failure and are modified by PAP-therapy. ( 29102807 )
2018
6
Low leptin concentration may identify heart failure patients with central sleep apnea. ( 28643476 )
2017
7
Predominant obstructive or central sleep apnea in patients with atrial fibrillation: influence of characterizing apneas versus apneas and hypopneas. ( 28899542 )
2017
8
Central sleep apnea during continuous positive airway pressure therapy in obstructive sleep apnea patients: from the compliance to adaptation, maladaptation and reflexes. ( 29268457 )
2017
9
Central Sleep Apnea in Patients with Congestive Heart Failure. ( 28477776 )
2017
10
Central Sleep Apnea and Stiff Person Syndrome: A Case Report. ( 28358591 )
2017
11
Association between central sleep apnea and left ventricular structure: the Multi-Ethnic Study of Atherosclerosis. ( 28220556 )
2017
12
Emergent central sleep apnea during CPAP therapy-clinical implications. ( 29268465 )
2017
13
Long-Term Experience with First-Generation Implantable Neurostimulation Device in Central Sleep Apnea Treatment. ( 28211952 )
2017
14
Rapid-eye-movement sleep-predominant central sleep apnea relieved by positive airway pressure: a case report. ( 28483860 )
2017
15
A Potential Novel Mechanism for Vagus Nerve Stimulator-Related Central Sleep Apnea. ( 28961186 )
2017
16
Relief for Central Sleep Apnea. ( 29164238 )
2017
17
Central Sleep Apnea in Heart Failure: Sleeping With the Wrong Enemy? ( 28335842 )
2017
18
Evaluation of the central sleep apnea in asymptomatic children with Chiari 1 malformation: an open question. ( 28382434 )
2017
19
Monitoring of nocturnal central sleep apnea in Heart failure patients using noncontact respiratory differences. ( 29060172 )
2017
20
Sleep Complaints and Sleep Architecture in Children With Idiopathic Central Sleep Apnea. ( 28212689 )
2017
21
Focus on Functional Delayed Central Sleep Apnea Following Cervical Laminectomy. An Example of Respiratory Dysfunction in Restorative Neurosurgical Procedures. ( 28120077 )
2017
22
Trajectories of Emergent Central Sleep Apnea During CPAP Therapy. ( 28629918 )
2017
23
Non-Mask-based Therapies for Central Sleep Apnea in Patients with Heart Failure. ( 28477779 )
2017
24
Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women. ( 28668820 )
2017
25
Central sleep apnea: the problem of diagnosis. ( 28153696 )
2017
26
Impairment of pulmonary diffusion correlates with hypoxemic burden in central sleep apnea heart failure patients. ( 28467884 )
2017
27
Respiratory drive in patients with chronic heart failure and central sleep apnea: Data from the Daunia Heart Failure Registry. ( 28065692 )
2017
28
Vertex Rolandic Spikes and Central Sleep Apnea inA aA Newborn. ( 27137362 )
2016
29
A novel therapeutic approach for central sleep apnea: Phrenic nerve stimulation by the remedA9Ar System. ( 26964705 )
2016
30
Identifying Predictors of Central Sleep Apnea/Cheyne-Stokes Breathing in Chronic Heart Failure: a Pathophysiological Approach. ( 28068279 )
2016
31
Central sleep apnea in children: experience at a single center. ( 27823711 )
2016
32
Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. ( 26894248 )
2016
33
Novel Therapies for the Treatment of Central Sleep Apnea. ( 27236059 )
2016
34
Treatment of central sleep apnea in heart failure patients: Benefit or harm? ( 27077544 )
2016
35
Is servoventilation in central sleep apnea syndrom still working?. ( 27209837 )
2016
36
Prognostic Importance of Novel Oxygen Desaturation Metrics in Patients with Heart Failure and Central Sleep Apnea. ( 27615064 )
2016
37
Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. ( 26886531 )
2016
38
A systematic review on prevalence and risk factors associated with treatment- emergent central sleep apnea. ( 27512510 )
2016
39
The effect of adaptive servo ventilation (ASV) on objective and subjective outcomes in Cheyne-Stokes respiration (CSR) with central sleep apnea (CSA) in heart failure (HF): A systematic review. ( 26995256 )
2016
40
Relationship between chronic kidney disease and central sleep apnea: the importance of volume management. ( 27638723 )
2016
41
A review of preventing central sleep apnea by inspired CO2. ( 27093535 )
2016
42
Ischemic Lesion Formation in Solitary Tract Nuclei During Central Sleep Apnea With Heart Failure. ( 26948864 )
2016
43
Central Sleep Apnea at High Altitude. ( 27343103 )
2016
44
Current treatment approaches and trials in central sleep apnea. ( 26961738 )
2016
45
Association of Central Sleep Apnea with Impaired Heart Structure and Cardiovascular Hemodynamics in Patients with Chronic Heart Failure. ( 27558771 )
2016
46
Central sleep apnea in multiple sclerosis: a pilot study. ( 27975178 )
2016
47
Probing the prevalence of central sleep apnea in patients with chronic kidney disease. ( 27638724 )
2016
48
End-Tidal CO2 Tension Is Predictive of Effective Nocturnal Oxygen Therapy in Patients with Chronic Heart Failure and Central Sleep Apnea. ( 27169493 )
2016
49
Congestive Heart Failure and Central Sleep Apnea. ( 26972039 )
2016
50
Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. ( 26886533 )
2016

Variations for Central Sleep Apnea

Expression for Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for Central Sleep Apnea

GO Terms for Central Sleep Apnea

Cellular components related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 NOS3 SRC

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.71 KCNK3 LEP NPPA NPPB
2 response to insulin GO:0032868 9.49 LEP NPPA
3 response to nutrient levels GO:0031667 9.48 LEP SRC
4 regulation of nitric-oxide synthase activity GO:0050999 9.46 LEP NOS3
5 cGMP biosynthetic process GO:0006182 9.43 NPPA NPPB
6 positive regulation of insulin receptor signaling pathway GO:0046628 9.37 LEP SRC
7 regulation of vascular permeability GO:0043114 9.32 NPPB SRC
8 receptor guanylyl cyclase signaling pathway GO:0007168 9.26 NPPA NPPB
9 ovulation from ovarian follicle GO:0001542 9.16 LEP NOS3
10 regulation of blood vessel size GO:0050880 9.13 NOS3 NPPA NPPB
11 regulation of blood pressure GO:0008217 8.92 LEP NOS3 NPPA NPPB

Molecular functions related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.56 LEP NPPA NPPB SRC
2 protein C-terminus binding GO:0008022 9.5 HSPB7 KCNK3 SRC
3 scaffold protein binding GO:0097110 9.37 NOS3 SRC
4 hormone activity GO:0005179 9.33 LEP NPPA NPPB
5 peptide hormone receptor binding GO:0051428 8.96 LEP NPPA
6 hormone receptor binding GO:0051427 8.8 NPPA NPPB SRC

Sources for Central Sleep Apnea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....