MCID: CNT015
MIFTS: 49

Central Sleep Apnea malady

Mental diseases, Neuronal diseases categories

Summaries for Central Sleep Apnea

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards: Central Sleep Apnea, also known as central sleep apnea, primary, is related to congestive heart failure and hypertension. An important gene associated with Central Sleep Apnea is NPPB (natriuretic peptide B), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Potassium transporters inward current. The compounds p00035 and hncs have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and tongue, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia:66 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Aliases & Classifications for Central Sleep Apnea

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 28ICD9CM, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

central sleep apnea 9 11
central sleep apnea, primary 63
primary central sleep apnea 9
sleep apnea, central 63


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Disease Ontology9 DOID:9220
ICD9CM28 327.21
MeSH36 D020182

Related Diseases for Central Sleep Apnea

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Central Sleep Apnea family:

Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure31.2NPPA, NPPB
2hypertension30.5NPPB, NPPA, LEP, NOS3
3primary pulmonary hypertension30.2NOS3, NPPB, NPPA
4myocardial infarction30.2NOS3, NPPA, NPPB
5sleep apnea11.3
6obstructive sleep apnea10.6
7chiari malformation10.4
8pharyngitis10.3
9systolic heart failure10.3
10dilated cardiomyopathy10.3
11hypothyroidism10.3
12idiopathic alveolar hypoventilation syndrome10.3
13acromegaly10.2
14leber hereditary optic neuropathy10.2
15hyperprolactinemia10.2
16cerebritis10.2
17joubert syndrome10.2
18carotid stenosis10.2
19cervicitis10.2
20craniosynostosis10.2
21esophagitis10.2
22leukemia10.2
23neuropathy10.2
24obesity10.2
25sleep disorder10.2
26chiari malformation type 110.2
27growth hormone deficiency10.2
28ataxia10.2
29autonomic dysfunction10.2
30hypoxia10.2
31insomnia10.2
32blindness10.2
33mitral valve disease10.1NPPA
34sick sinus syndrome10.1NPPA
35mitral valve stenosis10.1NPPA, NPPB
36syndrome of inappropriate antidiuretic hormone10.1NPPB, NPPA
37mitral valve insufficiency10.1NPPA, NPPB
38cor pulmonale10.1NPPB, NPPA
39heart valve disease10.1NPPB, NPPA
40hypertensive heart disease10.0NPPA, NPPB
41idiopathic edema10.0NPPA, NPPB
42aortic valve stenosis10.0NPPA, NPPB
43eating disorder10.0LEP, NPPB
44congenital heart disease10.0NPPB, NPPA
45primary hyperoxaluria10.0LEP, NPPA
46septic shock10.0NPPB, NOS3
47uremia10.0LEP, NOS3
48stroke, ischemic10.0NOS3, NPPA
49coronary artery disease10.0NPPB, NOS3, NPPA
50cerebrovascular disease10.0NPPB, NPPA, NOS3

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to central sleep apnea

Symptoms for Central Sleep Apnea

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Drugs & Therapeutics for Central Sleep Apnea

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Sleep Apnea

Drug clinical trials:

Search ClinicalTrials for Central Sleep Apnea

Search NIH Clinical Center for Central Sleep Apnea

Search CenterWatch for Central Sleep Apnea

Genetic Tests for Central Sleep Apnea

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Anatomical Context for Central Sleep Apnea

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34MalaCards
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MalaCards organs/tissues related to Central Sleep Apnea:

34
Heart, Brain, Tongue, Testes

Animal Models for Central Sleep Apnea or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Central Sleep Apnea:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5NOS3, LEP, KCNK3, KCNK9
2MP:00053798.5NOS3, LEP, KCNK3, KCNK9
3MP:00053698.5LEP, NOS3, NPPA, NPPB
4MP:00036317.4KCNK9, KCNK3, LEP, NOTO, NOS3
5MP:00053857.0NPPB, KCNK9, KCNK3, LEP, NOTO, NOS3

Publications for Central Sleep Apnea

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Sources:
53PubMed
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Articles related to Central Sleep Apnea:

(show top 50)    (show all 208)
idTitleAuthorsYear
1
Positive airway pressure therapy in patients with opioid-related central sleep apnea. (24062011)
2013
2
Differential timing of arousals in obstructive and central sleep apnea in patients with heart failure. (23946707)
2013
3
Tetraplegia is a Risk Factor for Central Sleep Apnea. (24114704)
2013
4
Pearls & oy-sters: treatment of central sleep apnea with topiramate. (22508854)
2012
5
Treatment of central sleep apnea in U.S. veterans. (23066368)
2012
6
Central sleep apnea is a predictor of cardiac readmission in hospitalized patients with systolic heart failure. (22748486)
2012
7
Treatment of Cheyne-Stokes respiration-central sleep apnea in patients with heart failure. (22370166)
2012
8
Effectiveness of Adaptive Servo Ventilation in the treatment of hypocapnic central sleep apnea of various etiologies. (22030207)
2011
9
The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea. (22131607)
2011
10
Central sleep apnea. (20488284)
2010
11
Central sleep apnea indicates autonomic dysfunction in asymptomatic carotid stenosis: a potential marker of cerebrovascular and cardiovascular risk. (20337190)
2010
12
Impact of sleeping position on central sleep apnea/Cheyne-Stokes respiration in patients with heart failure. (20093078)
2010
13
Isolated central sleep apnea in type I Chiari malformation: improvement after surgery. (20848584)
2010
14
"Awakenings": electrocardiographic findings in central sleep apnea. (20946562)
2010
15
Real-time dynamic carbon dioxide administration: a novel treatment strategy for stabilization of periodic breathing with potential application to central sleep apnea. (21087712)
2010
16
Central sleep apnea in cancer patients on opioids. (20678888)
2010
17
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
18
Central sleep apnea and ataxia caused by brainstem lesion due to chronic neuroleptospirosis. (19949038)
2009
19
Valve repair improves central sleep apnea in heart failure patients with valvular heart diseases. (19713650)
2009
20
Central sleep apnea in a geriatric patient treated with aripiprazole. (19300045)
2009
21
Heart failure, central sleep apnea, CPAP, and arousals: another piece of the puzzle. (19189772)
2009
22
Combined adaptive servo-ventilation and automatic positive airway pressure (anticyclic modulated ventilation) in co-existing obstructive and central sleep apnea syndrome and periodic breathing. (19303811)
2009
23
Quality of life in patients with congestive heart failure and central sleep apnea. (18203661)
2008
24
Expression of TASK-1 in brainstem and the occurrence of central sleep apnea in rats. (18272437)
2008
25
Influence of thermal drive on central sleep apnea in the preterm neonate. (18457243)
2008
26
Impaired pulmonary diffusing capacity and hypoxia in heart failure correlates with central sleep apnea severity. (18198261)
2008
27
Causality in the relationship between central sleep apnea and paroxysmal atrial fibrillation. (17644474)
2008
28
Treating central sleep apnea in heart failure: outcomes revisited. (17592088)
2007
29
Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea: a preliminary study. (17400681)
2007
30
Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). (17562959)
2007
31
Central sleep apnea: Pathophysiology and treatment. (17296668)
2007
32
Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing. (17803007)
2007
33
Assessment of central chemosensitivity and cardiac sympathetic nerve activity using I-123 MIBG imaging in central sleep apnea syndrome in patients with dilated cardiomyopathy. (17373339)
2007
34
CPAP should not be used for central sleep apnea in congestive heart failure patients. (17557466)
2006
35
Cardiac resynchronization therapy, central sleep apnea, and Cheyne-Stokes respiration in chronic heart failure patients. (15708718)
2005
36
Effect of CO2 inhalation on central sleep apnea and arousals from sleep. (15467327)
2004
37
Pembrey's dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. (12576341)
2003
38
Primary pulmonary hypertension with central sleep apnea: sudden death after bilevel positive airway pressure therapy. (10981861)
2000
39
Treatment of central sleep apnea in heart failure. (10893108)
2000
40
Article reviewed: A mechanism of central sleep apnea in patients with heart failure. (10733623)
2000
41
Central sleep apnea after interrupting longterm acetazolamide therapy. (9696283)
1998
42
Effects of cardiac dysfunction on non-hypercapnic central sleep apnea. (9440576)
1998
43
Continuous versus bilevel positive airway pressure in a patient with idiopathic central sleep apnea. (9105099)
1997
44
Central sleep apnea-hypopnea syndrome in heart failure: prevalence, impact, and treatment. (9085518)
1996
45
Hypocapnia and increased ventilatory responsiveness in patients with idiopathic central sleep apnea. (8520761)
1995
46
Interaction of hyperventilation and arousal in the pathogenesis of idiopathic central sleep apnea. (8049835)
1994
47
Central sleep apnea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patients with acromegaly. (8049836)
1994
48
Successful treatment of central sleep apnea with an oral prosthesis. (1935315)
1991
49
Differences in pharyngeal properties between snorers with predominantly central sleep apnea and those without sleep apnea. (3813202)
1987
50
Central sleep apnea and partial obstruction of the upper airway. (3296946)
1987

Variations for Central Sleep Apnea

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Expression for genes affiliated with Central Sleep Apnea

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for genes affiliated with Central Sleep Apnea

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Sources:
51PathCards, 54QIAGEN, 13EMD Millipore, 52PharmGKB, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Central Sleep Apnea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NPPB, NPPA
29.6KCNK9, KCNK3
3
Show member pathways
9.6KCNK3, KCNK9
4
Show member pathways
Nicotine Activity on Dopaminergic Neurons39
9.6KCNK3, KCNK9
5
Show member pathways
9.1NOS3, KCNK3, KCNK9

Compounds for genes affiliated with Central Sleep Apnea

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Central Sleep Apnea according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1p000354610.1NPPA, NPPB
2hncs4610.1NPPB, NPPA
3candoxatril46 1211.1NPPB, NPPA
4alacepril4610.1NPPB, NPPA
5imidapril46 5211.1NPPA, NPPB
6urodilatin4610.1NPPB, NPPA
7hanp4610.1NPPA, NPPB
8bisoprolol46 52 1212.1NPPA, NPPB
9trandolapril46 1211.1NPPB, NPPA
10dobutamine46 30 52 1213.1NPPB, NPPA
11moxonidine4610.0NPPA, NPPB
12fosinopril46 1211.0NPPB, NPPA
13enalaprilat4610.0NPPB, NPPA
14celiprolol4610.0NOS3, NPPB
15tetraethylammonium chloride629.9KCNK9, KCNK3
16dmp 543629.9KCNK9, KCNK3
17lisinopril46 52 25 1212.9NPPB, NPPA
18bl 1249629.9KCNK3, KCNK9
19ys-035 hydrochloride629.9KCNK3, KCNK9
20nppb30 46 6211.9NPPA, NPPB
21isosorbide dinitrate46 52 1211.9NPPA, NOS3
22mibg469.9NPPB, NPPA
23ramipril46 1210.8NPPB, NPPA
24papaverine46 3 1211.8NPPB, NOS3
25metoprolol46 52 30 25 1213.6NPPB, NPPA, NOS3
26cesium chloride46 6210.6KCNK3, KCNK9
27perindopril46 52 1211.6NPPA, NOS3, NPPB
28amlodipine46 52 25 1212.6NPPB, NPPA, NOS3
29carvedilol46 52 30 1212.6NPPB, NOS3, NPPA
30sildenafil30 46 52 25 1213.6NPPB, NPPA, NOS3
31s-nitroso-n-acetylpenicillamine469.6NPPA, NPPB, NOS3
32nitroglycerin46 1210.6NPPA, NPPB, NOS3
33ang ii469.6NPPB, NOS3, NPPA
34guanylate469.6NOS3, NPPA, NPPB
35cgmp46 3010.5NPPA, NOS3, NPPB
36telmisartan46 30 1211.5LEP, NPPB
37losartan46 52 30 1212.5LEP, NPPB, NPPA
38kt 582346 3010.4NOS3, NPPA
39anandamide62 46 30 2512.4LEP, KCNK9, KCNK3
408-bromo cgmp469.4NPPA, NPPB
418-isoprostane469.4NPPB, NOS3, LEP
42pravastatin46 52 30 25 1213.4NPPB, NOS3, LEP
43rosiglitazone30 46 52 25 1213.4LEP, NOS3, NPPB
44glycerol46 25 1211.2LEP, NOS3, NPPA
45l-nmma469.0LEP, NPPA, NPPB, NOS3
46phenylephrine46 30 25 1212.0NPPA, LEP, NOS3, NPPB
47sodium nitroprusside469.0NPPB, NPPA, NOS3, LEP
48prostacyclin469.0NPPB, NPPA, LEP, NOS3
49vegf468.6NPPB, NOS3, NPPA, LEP
50arginine468.6NOS3, NPPA, LEP, NPPB, KCNK3

GO Terms for genes affiliated with Central Sleep Apnea

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17Gene Ontology
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Cellular components related to Central Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6NPPB, NPPA, IK, LEP

Biological processes related to Central Sleep Apnea according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:0061829.8NPPA, NPPB
2receptor guanylyl cyclase signaling pathwayGO:0071689.8NPPB, NPPA
3cochlea developmentGO:0901029.6KCNK3, KCNK9
4ovulation from ovarian follicleGO:0015429.5NOS3, LEP
5female pregnancyGO:0075659.4NPPA, LEP
6regulation of blood vessel sizeGO:0508809.4NOS3, NPPA, NPPB
7potassium ion transportGO:0068139.3KCNK3, KCNK9
8response to insulinGO:0328689.3LEP, NPPA
9regulation of blood pressureGO:0082178.8NPPB, NPPA, NOS3, LEP

Molecular functions related to Central Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel activityGO:0052679.6KCNK3, KCNK9
2peptide hormone receptor bindingGO:0514289.1NPPA, LEP
3hormone activityGO:0051799.0NPPB, NPPA, LEP

Products for genes affiliated with Central Sleep Apnea

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Sources for Central Sleep Apnea

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet