MCID: CNT015
MIFTS: 44

Central Sleep Apnea malady

Categories: Mental diseases

Aliases & Classifications for Central Sleep Apnea

Aliases & Descriptions for Central Sleep Apnea:

Name: Central Sleep Apnea 12 14
Central Sleep Apnea Syndrome 12 69
Sleep Apnea, Central 42 69
Central Sleep Apnea, Primary 69
Primary Central Sleep Apnea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9220
ICD10 33 G47.31
ICD9CM 35 327.21
MeSH 42 D020182
SNOMED-CT 64 9741000119101
UMLS 69 C0751762

Summaries for Central Sleep Apnea

Disease Ontology : 12 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary : Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and idiopathic alveolar hypoventilation syndrome. An important gene associated with Central Sleep Apnea is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Prolactin Signaling Pathway and AGE/RAGE pathway. The drugs Gabapentin and Morphine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and testes, and related phenotype is respiratory system.

Wikipedia : 71 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Related Diseases for Central Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 sleep apnea 11.5
2 idiopathic alveolar hypoventilation syndrome 11.3
3 central hypoventilation syndrome, congenital 11.1
4 congestive heart failure 10.3
5 obstructive sleep apnea 10.2
6 inferolateral myocardial infarct 10.2 NPPA NPPB
7 syringomelia hyperkeratosis 10.2 NPPA NPPB
8 american histoplasmosis 10.1 NPPA NPPB
9 eastern equine encephalitis 10.1 NPPA NPPB
10 ectodermal dysplasia 9, hair/nail type 10.1 NOS3 NPPB
11 iida kannari syndrome 10.1 NPPA NPPB
12 vitreous disease 10.1 NOS3 NPPB
13 iris disease 10.1 NOS3 NPPA
14 eye degenerative disease 10.1 NOS3 NPPB
15 rapidly progressive glomerulonephritis 10.1 NOS3 NPPA
16 suppurative otitis media 10.1 NPPA NPPB
17 joint disorders 10.1 NOS3 NPPB
18 urinary bladder posterior wall cancer 10.1 NPPA NPPB
19 ichthyosis lamellar 3 10.0 LEP NPPA NPPB
20 systolic heart failure 10.0
21 chiari malformation 10.0
22 cardiomyopathy 10.0
23 lymphadenitis 10.0 NOS3 NPPA NPPB
24 cerebral convexity meningioma 10.0 NOS3 NPPA NPPB
25 3-hydroxyisobutryl-coa hydrolase deficiency 10.0 LEP NPPA
26 pyelonephritis 10.0 NOS3 NPPA NPPB
27 limb ischemia 10.0 LEP NOS3
28 welander distal myopathy 10.0 LEP NOS3
29 diabetic encephalopathy 10.0 LEP NOS3 NPPB
30 ceroid lipofuscinosis, neuronal, kufs type, adult onset 9.9 NPPA NPPB
31 pulmonary hypertension 9.9
32 dilated cardiomyopathy 9.9
33 atrial fibrillation 9.9
34 heart disease 9.9
35 kidney disease 9.9
36 xanthogranulomatous pyelonephritis 9.9 NOS3 NPPA NPPB
37 stiff-person syndrome 9.8
38 hypothyroidism 9.8
39 pharyngitis 9.8
40 cerebritis 9.8
41 sleep disorder 9.8
42 hypertension, essential 9.8 LEP NOS3 NPPA NPPB
43 sydenham chorea 9.8 KCNK3 NOS3 NPPA NPPB
44 myocardial infarction 9.7
45 obesity 9.7
46 hyperprolactinemia 9.7
47 vici syndrome 9.7
48 laryngomalacia 9.7
49 craniosynostosis 9.7
50 leukemia 9.7

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to Central Sleep Apnea

Symptoms & Phenotypes for Central Sleep Apnea

MGI Mouse Phenotypes related to Central Sleep Apnea:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 8.92 KCNK3 LEP NOS3 SRC

Drugs & Therapeutics for Central Sleep Apnea

Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 315)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
2
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
3
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
4
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
5
Budesonide Approved Phase 4 51333-22-3 63006 5281004
6
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
7
Remifentanil Approved Phase 4,Phase 1,Early Phase 1 132875-61-7 60815
8
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 2078-54-8 4943
9
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
10
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 437-38-7 3345
12
Dopamine Approved Phase 4,Phase 1 51-61-6, 62-31-7 681
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
14
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
15
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
16
Losartan Approved Phase 4 114798-26-4 3961
17
Donepezil Approved Phase 4 120014-06-4 3152
18
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
19
Adalimumab Approved Phase 4 331731-18-1 16219006
20
Olanzapine Approved, Investigational Phase 4,Phase 1 132539-06-1 4585
21
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
22
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
23
Acetazolamide Approved, Vet_approved Phase 4,Phase 3,Phase 2 59-66-5 1986
24
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
25
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
26
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
27
Zolpidem Approved Phase 4 82626-48-0 5732
28
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68693-11-8 4236
29
Trazodone Approved, Investigational Phase 4,Phase 1,Early Phase 1 19794-93-5 5533
30
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2 2216-51-5 16666
31
Eszopiclone Approved Phase 4,Phase 2,Early Phase 1 138729-47-2 969472
32
Zopiclone Approved Phase 4,Phase 3 43200-80-2 5735
33
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112111-43-0
34
Sodium oxybate Approved Phase 4 502-85-2 5360545
35
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
36
Levodopa Approved Phase 4 59-92-7 6047
37
Apomorphine Approved, Investigational Phase 4 41372-20-7, 58-00-4 6005
38
Carbidopa Approved Phase 4 28860-95-9 34359 38101
39
Desflurane Approved Phase 4 57041-67-5 42113
40
Topiramate Approved Phase 4 97240-79-4 5284627
41
Phentermine Approved, Illicit Phase 4 122-09-8 4771
42
Loperamide Approved Phase 4 53179-11-6 3955
43
Opium Approved, Illicit Phase 4 8008-60-4
44
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
45
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
46
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
47
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
48 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
49 insulin Phase 4,Phase 3,Phase 2
50
Dexlansoprazole Phase 4 138530-94-6, 103577-45-3 9578005

Interventional clinical trials:

(show top 50) (show all 758)
id Name Status NCT ID Phase
1 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
2 Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4
3 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Unknown status NCT00560586 Phase 4
4 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
5 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
6 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
7 Sleep Apnea. Concordance Between Non-reference and Reference Centres Completed NCT00424658 Phase 4
8 An Investigation of the Sleep Architecture and Consequent Cognitive Changes in Olanzapine-Treated Depressed Patients Completed NCT00520507 Phase 4
9 Continuous Positive Airway Pressure (CPAP) Promotion And Prognosis - the Army Sleep Apnea Program (ASAP) Completed NCT00612157 Phase 4
10 CPAP in SAHS Patients With Hypertension Completed NCT02398032 Phase 4
11 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed NCT01344759 Phase 4
12 Ezopiclone Improves the Quality of Overnight Polysomnography Completed NCT00507117 Phase 4
13 Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment Completed NCT00701428 Phase 4
14 Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea Completed NCT01181570 Phase 4
15 Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude Completed NCT00928655 Phase 4
16 Treatment of Sleep Disordered Breathing In Acute Decompensated Heart Failure Patients Completed NCT00804349 Phase 4
17 Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4
18 Serotonin and the Upper Airway in Obstructive Sleep Apnea Completed NCT00100464 Phase 4
19 "Pilot Study of Armodafinil in Patients With Dementia With Lewy Bodies" Completed NCT01023672 Phase 4
20 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
21 The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726) Completed NCT00359216 Phase 4
22 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed NCT00518986 Phase 4
23 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4
24 Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea Completed NCT00307957 Phase 4
25 The Effect of Anticholinesterase Drugs on Sleep in Alzheimer's Disease Patients Completed NCT00480870 Phase 4
26 Study to Evaluate Armodafinil Treatment in Improving Prefrontal Cortical Activation and Working Memory Performance Completed NCT00711516 Phase 4
27 Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea Completed NCT00772044 Phase 4
28 A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial Completed NCT01895348 Phase 4
29 Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) Patients Completed NCT00708786 Phase 4
30 Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude Completed NCT02450994 Phase 4
31 Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome Recruiting NCT03031626 Phase 4
32 Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance Recruiting NCT02820441 Phase 4
33 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4
34 Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome Recruiting NCT02717780 Phase 4
35 Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea Recruiting NCT02494102 Phase 4
36 Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease Recruiting NCT03111485 Phase 4
37 Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure Recruiting NCT01128816 Phase 4
38 Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea. Recruiting NCT02963597 Phase 4
39 CPAP Effect on the Progression of Diabetic Retinopathy in Patients With Sleep Apnea Recruiting NCT02874313 Phase 4
40 Telemedicine Monitoring of Sleep Apnea in Stroke Recruiting NCT02748681 Phase 4
41 Oxygen Versus PAP for Treatment of Sleep Apnea in Chronic Heart Failure Recruiting NCT01807897 Phase 4
42 Impact of Intrathecal Morphine on Sleep Apnea Syndrome Recruiting NCT02566226 Phase 4
43 Somnodent vs Herbst in Mild and Moderate OSA Patients Recruiting NCT02724865 Phase 4
44 Ketamine Infusion for Pediatric Patients With Obstructive Sleep Apnea Syndrome (OSAS) After Tonsillectomy Recruiting NCT02425202 Phase 4
45 Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes Recruiting NCT02746874 Phase 4
46 Inspire® Post-Approval Study / Protocol Number 2014-001 Recruiting NCT02413970 Phase 4
47 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4
48 Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy Recruiting NCT02643979 Phase 4
49 Ketamine for Pain Relief in Bariatric Surgery Recruiting NCT03052673 Phase 4
50 Surgery Versus Best Medical Management for the Long Term Remission of Type 2 Diabetes and Related Diseases (REMISSION) Recruiting NCT02390973 Phase 4

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

Genetic Tests for Central Sleep Apnea

Anatomical Context for Central Sleep Apnea

MalaCards organs/tissues related to Central Sleep Apnea:

39
Heart, Kidney, Testes, Tongue, Brain

Publications for Central Sleep Apnea

Articles related to Central Sleep Apnea:

(show top 50) (show all 284)
id Title Authors Year
1
Respiratory drive in patients with chronic heart failure and central sleep apnea: Data from the Daunia Heart Failure Registry. ( 28065692 )
2017
2
Central Sleep Apnea and Stiff Person Syndrome: A Case Report. ( 28358591 )
2017
3
Medium Increased Risk for Central Sleep Apnea but Not Obstructive Sleep Apnea in Long-Term Opioid Users: A Systematic Review and Meta-Analysis. ( 26943709 )
2016
4
Clinical predictors of central sleep apnea evoked by positive airway pressure titration. ( 27555802 )
2016
5
Severe Central Sleep Apnea Associated WithA Chronic Baclofen Therapy: A Case Series. ( 27157226 )
2016
6
Relationship between chronic kidney disease and central sleep apnea: the importance of volume management. ( 27638723 )
2016
7
A systematic review on prevalence and risk factors associated with treatment- emergent central sleep apnea. ( 27512510 )
2016
8
Central Sleep Apnea at High Altitude. ( 27343103 )
2016
9
End-Tidal CO2 Tension Is Predictive of Effective Nocturnal Oxygen Therapy in Patients with Chronic Heart Failure and Central Sleep Apnea. ( 27169493 )
2016
10
Novel Therapies for the Treatment of Central Sleep Apnea. ( 27236059 )
2016
11
Current treatment approaches and trials in central sleep apnea. ( 26961738 )
2016
12
Probing the prevalence of central sleep apnea in patients with chronic kidney disease. ( 27638724 )
2016
13
Updated Adaptive Servo-Ventilation Recommendations for the 2012 AASM Guideline: "The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses". ( 27092695 )
2016
14
The effect of adaptive servo ventilation (ASV) on objective and subjective outcomes in Cheyne-Stokes respiration (CSR) with central sleep apnea (CSA) in heart failure (HF): A systematic review. ( 26995256 )
2016
15
Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. ( 26886531 )
2016
16
Association between polymorphisms of the HSPB7 gene and Cheyne-Stokes respiration with central sleep apnea in patients with dilated cardiomyopathy and congestive heart failure. ( 27441470 )
2016
17
Pathophysiology of central sleep apnea in chronic kidney disease. ( 27752026 )
2016
18
Treatment of central sleep apnea in heart failure patients: Benefit or harm? ( 27077544 )
2016
19
Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. ( 26886532 )
2016
20
A novel therapeutic approach for central sleep apnea: Phrenic nerve stimulation by the remedA9Ar System. ( 26964705 )
2016
21
Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. ( 26886534 )
2016
22
Association of Central Sleep Apnea with Impaired Heart Structure and Cardiovascular Hemodynamics in Patients with Chronic Heart Failure. ( 27558771 )
2016
23
Ischemic Lesion Formation in Solitary Tract Nuclei During Central Sleep Apnea With Heart Failure. ( 26948864 )
2016
24
Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. ( 26886533 )
2016
25
High Coronary Heart Disease Risk in Hemodialysis Patients with Central Sleep Apnea: A Pilot Study. ( 27771703 )
2016
26
Prognostic Importance of Novel Oxygen Desaturation Metrics in Patients with Heart Failure and Central Sleep Apnea. ( 27615064 )
2016
27
A review of preventing central sleep apnea by inspired CO2. ( 27093535 )
2016
28
Central sleep apnea in multiple sclerosis: a pilot study. ( 27975178 )
2016
29
Sympathetic nervous system, systolic heart failure, and central sleep apnea: Are we about to find the missing link? ( 27457530 )
2016
30
Vertex Rolandic Spikes and Central Sleep Apnea inA aA Newborn. ( 27137362 )
2016
31
Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. ( 26894248 )
2016
32
Congestive Heart Failure and Central Sleep Apnea. ( 26972039 )
2016
33
Central sleep apnea in children: experience at a single center. ( 27823711 )
2016
34
Ischemic Lesion Formation in Solitary Tract Nuclei During Central Sleep Apnea With Heart Failurea88- Reply. ( 26948866 )
2016
35
Ischemic Lesion Formation in Solitary Tract Nuclei During Central Sleep Apnea With Heart Failure - Reply -a88Adaptive Servo-Ventilation Therapy for Patients With Chronic Heart Failure in a Confirmatory, Multicenter, Randomized, Controlled Study. ( 26948865 )
2016
36
Identifying Predictors of Central Sleep Apnea/Cheyne-Stokes Breathing in Chronic Heart Failure: a Pathophysiological Approach. ( 28068279 )
2016
37
Is servoventilation in central sleep apnea syndrom still working?. ( 27209837 )
2016
38
Relationship between central sleep apnea and Cheyne-Stokes Respiration. ( 26961739 )
2016
39
Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea. ( 25770408 )
2015
40
Prevalence of central sleep apnea during continous positive airway pressure (CPAP) titration in subjects with obstructive sleep apnea syndrome at an altitude of 2640a88m. ( 25683561 )
2015
41
Severe Central Sleep Apnea in Vici Syndrome. ( 26482670 )
2015
42
Prognostic impact of central sleep apnea in patients with heart failure. ( 25451705 )
2015
43
Stiff-person syndrome with central sleep apnea after thymoma excision: report of the first known case. ( 26238984 )
2015
44
Home-use servo-ventilation therapy in chronic pain patients with central sleep apnea: initial and 3-month follow-up. ( 25813356 )
2015
45
Central sleep apnea in pregnant women with sleep disordered breathing. ( 25566940 )
2015
46
Treatment-emergent central sleep apnea at high altitude. ( 25465532 )
2015
47
Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. ( 25572513 )
2015
48
Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. ( 26323938 )
2015
49
Exercise End-Tidal Carbon Dioxide Predicts Central Sleep Apnea in Heart Failure Patients. ( 25742609 )
2015
50
A 44-year-old woman with excessive sleepiness. Opioid-induced central sleep apnea. ( 25451363 )
2014

Variations for Central Sleep Apnea

Expression for Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for Central Sleep Apnea

GO Terms for Central Sleep Apnea

Cellular components related to Central Sleep Apnea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 NOS3 SRC

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.49 LEP SRC
2 response to insulin GO:0032868 9.48 LEP NPPA
3 response to nutrient levels GO:0031667 9.46 LEP SRC
4 regulation of nitric-oxide synthase activity GO:0050999 9.43 LEP NOS3
5 cGMP biosynthetic process GO:0006182 9.4 NPPA NPPB
6 positive regulation of insulin receptor signaling pathway GO:0046628 9.37 LEP SRC
7 regulation of vascular permeability GO:0043114 9.32 NPPB SRC
8 receptor guanylyl cyclase signaling pathway GO:0007168 9.26 NPPA NPPB
9 ovulation from ovarian follicle GO:0001542 9.16 LEP NOS3
10 regulation of blood vessel size GO:0050880 9.13 NOS3 NPPA NPPB
11 regulation of blood pressure GO:0008217 8.92 LEP NOS3 NPPA NPPB

Molecular functions related to Central Sleep Apnea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.26 NOS3 SRC
2 peptide hormone receptor binding GO:0051428 9.16 LEP NPPA
3 hormone activity GO:0005179 9.13 LEP NPPA NPPB
4 receptor binding GO:0005102 8.92 LEP NPPA NPPB SRC

Sources for Central Sleep Apnea

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
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18 FMA
28 GO
29 GTR
30 HGMD
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33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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