MCID: CNT015
MIFTS: 42

Central Sleep Apnea malady

Summaries for Central Sleep Apnea

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

MalaCards: Central Sleep Apnea, also known as central sleep apnea, primary, is related to congestive heart failure and hypertension. An important gene associated with Central Sleep Apnea is NPPB (natriuretic peptide B), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Potassium transporters: inward current. The compounds hncs and p00035 have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related mouse phenotype cardiovascular system.

Disease Ontology:8 A sleep disorder involving diminished capability to breath for short periods of time.

Aliases & Classifications for Central Sleep Apnea

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

central sleep apnea 8 10
central sleep apnea, primary 60
primary central sleep apnea 8
sleep apnea, central 60


External Ids:

Disease Ontology8 DOID:9220
MeSH34 D020182
ICD9CM27 327.21

Related Diseases for Central Sleep Apnea

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Central Sleep Apnea family:

Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure31.1NPPA, NPPB
2hypertension30.5NOS3, NPPA, NPPB
3stroke, ischemic30.4NOS3, NPPA
4dilated cardiomyopathy30.4NPPA, NPPB
5heart valve disease30.2NPPB, NPPA
6primary pulmonary hypertension30.2NPPB, NPPA
7pharyngitis10.3
8systolic heart failure10.3
9hypothyroidism10.3
10idiopathic alveolar hypoventilation syndrome10.3
11carotid stenosis10.2
12hyperprolactinemia10.2
13cerebritis10.2
14acromegaly10.2
15leber hereditary optic neuropathy10.2
16diastolic heart failure10.2
17adult syndrome10.2
18joubert syndrome10.2
19cervicitis10.2
20craniosynostosis10.2
21esophagitis10.2
22leukemia10.2
23myocardial infarction10.2
24neuropathy10.2
25obesity10.2
26sleep disorder10.2
27congenital central hypoventilation syndrome10.2
28image syndrome10.2
29central nervous system teratoma10.2
30myocarditis10.0NPPB
31hepatopulmonary syndrome10.0NOS3
32thromboembolism10.0NOS3
33sick sinus syndrome10.0NPPA
34graves' disease10.0NOS3
35hyperaldosteronism10.0NPPA
36pulmonary embolism10.0NPPB
37mitral valve insufficiency10.0NPPB, NPPA
38mitral valve stenosis10.0NPPB, NPPA
39syndrome of inappropriate antidiuretic hormone10.0NPPB, NPPA
40idiopathic edema10.0NPPB, NPPA
41aortic valve stenosis10.0NPPB, NPPA
42hypertensive heart disease10.0NPPA, NPPB
43cor pulmonale10.0NPPA, NPPB
44congenital heart defect10.0NPPA, NPPB
45acute myocardial infarction10.0NPPA, NPPB
46liver cirrhosis10.0NPPA, NOS3
47ischemic heart disease10.0NPPB, NPPA, NOS3
48coronary artery disease10.0NPPB, NPPA, NOS3
49chronic kidney failure10.0NPPB, NPPA, NOS3
50coronary heart disease10.0NOS3, NPPB

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to central sleep apnea

Clinical Features for Central Sleep Apnea

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Drugs & Therapeutics for Central Sleep Apnea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Central Sleep Apnea

Drug clinical trials:

Search ClinicalTrials for Central Sleep Apnea

Search NIH Clinical Center for Central Sleep Apnea

Search CenterWatch for Central Sleep Apnea

Genetic Tests for Central Sleep Apnea

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Anatomical Context for Central Sleep Apnea

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32MalaCards
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MalaCards organs/tissues related to Central Sleep Apnea:

32
Heart, Brain, Testes, Tongue

Animal Models for Central Sleep Apnea or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Central Sleep Apnea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.3NOTO, NOS3, NPPA, NPPB, KCNK3, KCNK9

Publications for Central Sleep Apnea

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50PubMed
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Articles related to Central Sleep Apnea:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Differential timing of arousals in obstructive and central sleep apnea in patients with heart failure. (23946707)
2013
2
A case of positional central sleep apnea. (23493439)
2013
3
Type I Chiari malformation presenting central sleep apnea. (24161709)
2013
4
Adapting our approach to treatment-emergent central sleep apnea. (23904668)
2013
5
Central sleep apnea interfering with adequate left ventricular filling in a patient with left ventricular assist device. (23372470)
2013
6
Treatment of Cheyne-Stokes respiration-central sleep apnea in patients with heart failure. (22370166)
2012
7
Slowly progressive sleep apnea in late-onset central hypoventilation syndrome. (22507157)
2012
8
The appearance of central sleep apnea after treatment of obstructive sleep apnea. (22871763)
2012
9
Relation of natriuretic peptide concentrations to central sleep apnea in patients with heart failure. (21636668)
2011
10
Impact of sleeping position on central sleep apnea/Cheyne-Stokes respiration in patients with heart failure. (20093078)
2010
11
Central Sleep Apnea in Patients due to Severe Aortic Stenosis. (20592995)
2010
12
Central sleep apnea detection from ECG-derived respiratory signals. Application of multivariate recurrence plot analysis. (20490427)
2010
13
Secondary nocturnal enuresis caused by central sleep apnea from Chiari malformation type 1. (19854680)
2010
14
Effective treatment for idiopathic central sleep apnea? (19968045)
2009
15
Valve repair improves central sleep apnea in heart failure patients with valvular heart diseases. (19713650)
2009
16
Central sleep apnea in a geriatric patient treated with aripiprazole. (19300045)
2009
17
Heart failure, central sleep apnea, CPAP, and arousals: another piece of the puzzle. (19189772)
2009
18
Effect of continuous positive airway pressure on sleep structure in heart failure patients with central sleep apnea. (19189783)
2009
19
Quality of life in patients with congestive heart failure and central sleep apnea. (18203661)
2008
20
Causality in the relationship between central sleep apnea and paroxysmal atrial fibrillation. (17644474)
2008
21
Alleviation of pulmonary hypertension by cardiac resynchronization therapy is associated with improvement in central sleep apnea. (19067803)
2008
22
Images in cardiovascular medicine. Central sleep apnea induces ventricular bigeminus: conclusions from a single polygraphy. (18809809)
2008
23
Effects of dynamic bilevel positive airway pressure support on central sleep apnea in men with heart failure. (17951617)
2008
24
Bi-level positive airway pressure ventilation for treating heart failure with central sleep apnea that is unresponsive to continuous positive airway pressure. (18577818)
2008
25
Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing. (17803007)
2007
26
Central sleep apnea on commencement of continuous positive airway pressure in patients with a primary diagnosis of obstructive sleep apnea-hypopnea. (17803008)
2007
27
Does the severity of central sleep apnea correlate with respiratory gas indexes during cardiopulmonary exercise testing? (17268123)
2006
28
Lateral sleeping position reduces severity of central sleep apnea / Cheyne-Stokes respiration. (16944673)
2006
29
The development of central sleep apnea with an oral appliance. (16194621)
2006
30
Cardiac resynchronization therapy, central sleep apnea, and Cheyne-Stokes respiration in chronic heart failure patients. (15708718)
2005
31
Central sleep apnea in stable methadone maintenance treatment patients. (16162728)
2005
32
Effectiveness of short-term treatment with nocturnal oxygen therapy for central sleep apnea in patients with congestive heart failure. (16127894)
2005
33
Raised sympathetic nerve activity in heart failure and central sleep apnea is due to heart failure severity. (12642360)
2003
34
Polysomnographic features of idiopathic central sleep apnea. (12047616)
2002
35
Short-term CPAP does not influence the increased CO2 drive in idiopathic central sleep apnea. (12174695)
2002
36
Central Sleep Apnea and Hypoventilation Syndrome. (11123858)
2001
37
Apnea during spinal anesthesia in an unsedated patient with central sleep apnea syndrome. (11435058)
2001
38
Central sleep apnea and heart failure. (10660391)
2000
39
Central sleep apnea and heart failure. (10660390)
2000
40
Pathophysiology of central sleep apnea syndrome. (10893106)
2000
41
A polysomnographic study on masticatory and tongue muscle activity during obstructive and central sleep apnea. (9781863)
1998
42
Relationship between CO2 drive and characteristics of apneas in obstructive and central sleep apnea. (9865592)
1998
43
Central sleep apnea. (9044468)
1997
44
Hypersomnolence and pure central sleep apnea associated with the Chiari I malformation. (7769182)
1995
45
Pharyngeal narrowing/occlusion during central sleep apnea. (7649916)
1995
46
Mechanisms and management of central sleep apnea. (1732682)
1992
47
Termination of central sleep apnea episodes by upper airway stimulation using intermittent positive pressure ventilation. (2036846)
1991
48
Differences in pharyngeal properties between snorers with predominantly central sleep apnea and those without sleep apnea. (3813202)
1987
49
Characteristics of obstructive and central sleep apnea in the elderly: an interim report. (3593813)
1987
50
Central sleep apnea and acetazolamide therapy. (6860061)
1983

Genetic Variations for Central Sleep Apnea

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Expression for genes affiliated with Central Sleep Apnea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for genes affiliated with Central Sleep Apnea

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Sources:
51QIAGEN, 12EMD Millipore, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Central Sleep Apnea

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Central Sleep Apnea according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1hncs4410.1NPPA, NPPB
2p000354410.1NPPA, NPPB
3candoxatril44 1111.1NPPB, NPPA
4alacepril4410.1NPPB, NPPA
5imidapril4410.1NPPB, NPPA
6urodilatin4410.0NPPA, NPPB
7hanp4410.0NPPB, NPPA
8bisoprolol44 49 1112.0NPPA, NPPB
9trandolapril44 1111.0NPPB, NPPA
10dobutamine44 28 1112.0NPPA, NPPB
11moxonidine4410.0NPPA, NPPB
12fosinopril44 1111.0NPPA, NPPB
13celiprolol4410.0NPPB, NOS3
14enalaprilat4410.0NPPB, NPPA
15lisinopril44 11 2412.0NPPB, NPPA
16nppb44 59 2811.9NPPB, NPPA
17mibg449.9NPPB, NPPA
18ramipril44 1110.9NPPB, NPPA
198-bromo cgmp449.9NPPA, NPPB
20papaverine44 2 1111.9NPPB, NOS3
21isosorbide dinitrate44 49 1111.9NOS3, NPPA
22kt 582344 2810.7NPPA, NOS3
23enalapril44 49 1111.7NPPB, NPPA
24candesartan44 28 1111.7NPPB, NOS3
25Doxapram119.7KCNK9, KCNK3
26spironolactone49 44 59 28 1113.6NPPA, NPPB
27ng-nitro-l-arginine449.6NPPA, NOS3
28tetraethylammonium chloride599.6KCNK9, KCNK3
298-isoprostane449.6NPPB, NOS3
30bl 1249599.6KCNK3, KCNK9
31metoprolol44 28 49 11 2413.6NPPA, NOS3, NPPB
32perindopril44 49 1111.6NPPB, NPPA, NOS3
33ys-035 hydrochloride599.6KCNK3, KCNK9
34amlodipine44 49 11 2412.6NPPA, NPPB, NOS3
35carvedilol44 49 28 1112.6NPPB, NPPA, NOS3
36sildenafil44 49 28 11 2413.6NPPA, NOS3, NPPB
37dmp 543599.6KCNK9, KCNK3
38s-nitroso-n-acetylpenicillamine449.6NPPB, NPPA, NOS3
39nitroglycerin44 1110.6NPPA, NOS3, NPPB
40ang ii449.6NPPA, NPPB, NOS3
41l-nmma449.5NOS3, NPPA, NPPB
42phenylephrine44 28 11 2412.5NOS3, NPPB, NPPA
43sodium nitroprusside449.5NOS3, NPPA, NPPB
44guanylate449.5NPPB, NPPA, NOS3
45allopurinol44 49 1111.5NOS3, NPPB
46cgmp44 2810.5NOS3, NPPA, NPPB
47cesium chloride44 5910.4KCNK9, KCNK3
48prostacyclin449.4NOS3, NPPA, NPPB
49phosphoramidon44 1110.3NPPB, NPPA
50arginine448.5KCNK3, NOS3, NPPB, NPPA

GO Terms for genes affiliated with Central Sleep Apnea

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16Gene Ontology
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Biological processes related to Central Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:0061829.5NPPB, NPPA
2receptor guanylyl cyclase signaling pathwayGO:0071689.3NPPA, NPPB
3cochlea developmentGO:0901029.2KCNK3, KCNK9
4regulation of blood vessel sizeGO:0508809.2NOS3, NPPA, NPPB
5regulation of blood pressureGO:0082179.1NOS3, NPPA, NPPB

Molecular functions related to Central Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel activityGO:0052679.2KCNK3, KCNK9

Products for genes affiliated with Central Sleep Apnea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Central Sleep Apnea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet