MCID: CNT015
MIFTS: 42

Central Sleep Apnea malady

Neuronal diseases category

Summaries for Central Sleep Apnea

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Disease Ontology:9 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary: Central Sleep Apnea, also known as central sleep apnea, primary, is related to congestive heart failure and atrial fibrillation. An important gene associated with Central Sleep Apnea is NPPB (natriuretic peptide B), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Potassium transporters inward current. The compounds p00035 and hncs have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia:63 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Aliases & Classifications for Central Sleep Apnea

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Central Sleep Apnea, Aliases & Descriptions:

Name: Central Sleep Apnea 9 11
Central Sleep Apnea, Primary 60
 
Primary Central Sleep Apnea 9
Sleep Apnea, Central 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:9220
ICD9CM27 327.21
MeSH33 D020182

Related Diseases for Central Sleep Apnea

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Diseases in the Sleep Apnea family:

central sleep apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure31.3NPPB, NPPA
2atrial fibrillation30.8NPPA, NPPB
3pulmonary hypertension30.5NPPB, NPPA, NOS3
4myocardial infarction30.0NPPB, NPPA, NOS3
5sleep apnea11.4
6obstructive sleep apnea10.7
7chiari malformation10.4
8mitral valve disease10.4NPPA
9sick sinus syndrome10.4NPPA
10dilated cardiomyopathy10.3
11pharyngitis10.3
12systolic heart failure10.3
13cerebritis10.3
14hypothyroidism10.3
15sleep disorder10.3
16idiopathic alveolar hypoventilation syndrome10.3
17syndrome of inappropriate antidiuretic hormone10.2NPPA, NPPB
18mitral valve insufficiency10.2NPPA, NPPB
19mitral valve stenosis10.2NPPA, NPPB
20cor pulmonale10.2NPPA, NPPB
21heart valve disease10.2NPPA, NPPB
22hypertensive heart disease10.2NPPB, NPPA
23idiopathic edema10.2NPPA, NPPB
24hyperprolactinemia10.2
25obesity10.2
26craniosynostosis10.2
27leukemia10.2
28acromegaly10.2
29leber hereditary optic neuropathy10.2
30carotid stenosis10.2
31cervicitis10.2
32esophagitis10.2
33neuropathy10.2
34chiari malformation type 110.2
35growth hormone deficiency10.2
36laryngomalacia10.2
37ataxia10.2
38autonomic dysfunction10.2
39chronic pain10.2
40hypoxia10.2
41blindness10.2
42aortic valve disease 210.2NPPB, NPPA
43eating disorder10.2LEP, NPPB
44congenital heart disease10.1NPPB, NPPA
45primary hyperoxaluria9.9LEP, NPPA
46uremia9.9NOS3, LEP
47stroke, ischemic9.8NPPA, NOS3
48coronary artery disease9.8NPPB, NPPA, NOS3
49liver cirrhosis9.8LEP, NOS3, NPPA
50preeclampsia/eclampsia 19.8LEP, NOS3, NPPA

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to central sleep apnea

Symptoms for Central Sleep Apnea

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Drugs & Therapeutics for Central Sleep Apnea

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Drug clinical trials:

Search ClinicalTrials for Central Sleep Apnea

Search NIH Clinical Center for Central Sleep Apnea

Genetic Tests for Central Sleep Apnea

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Anatomical Context for Central Sleep Apnea

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MalaCards organs/tissues related to Central Sleep Apnea:

31
Heart, Brain, Testes, Tongue

Animal Models for Central Sleep Apnea or affiliated genes

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MGI Mouse Phenotypes related to Central Sleep Apnea:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5NOS3, LEP, KCNK3, KCNK9
2MP:00053798.5NOS3, LEP, KCNK3, KCNK9
3MP:00053698.5LEP, NOS3, NPPA, NPPB
4MP:00036317.4KCNK9, KCNK3, LEP, NOTO, NOS3
5MP:00053857.0NPPB, KCNK9, KCNK3, LEP, NOTO, NOS3

Publications for Central Sleep Apnea

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Articles related to Central Sleep Apnea:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. (25572513)
2015
2
Prevalence of central sleep apnea during continous positive airway pressure (CPAP) titration in subjects with obstructive sleep apnea syndrome at an altitude of 2640a88m. (25683561)
2015
3
Effects of nocturnal oxygen therapy in patients with chronic heart failure and central sleep apnea: CHF-HOT study. (25348726)
2014
4
Left atrial size, chemosensitivity, and central sleep apnea in heart failure. (24522490)
2014
5
Adaptive servo-ventilation for the treatment of central sleep apnea in congestive heart failure: what have we learned? (25211247)
2014
6
Bradyarrhythmias may induce central sleep apnea in a patient with obstructive sleep apnea. (24748048)
2014
7
A novel therapeutic approach for the treatment of central sleep apnea: The remedA9Ar system. (24726495)
2014
8
Chiari 1 Malformation Presenting as Central Sleep Apnea during Pregnancy: A Case Report, Treatment Considerations, and Review of the Literature. (25386156)
2014
9
Positive airway pressure therapy in patients with opioid-related central sleep apnea. (24062011)
2013
10
Differential timing of arousals in obstructive and central sleep apnea in patients with heart failure. (23946707)
2013
11
Pearls & oy-sters: treatment of central sleep apnea with topiramate. (22508854)
2012
12
Treatment of central sleep apnea in U.S. veterans. (23066368)
2012
13
Central sleep apnea is a predictor of cardiac readmission in hospitalized patients with systolic heart failure. (22748486)
2012
14
Treatment of Cheyne-Stokes respiration-central sleep apnea in patients with heart failure. (22370166)
2012
15
Effectiveness of Adaptive Servo Ventilation in the treatment of hypocapnic central sleep apnea of various etiologies. (22030207)
2011
16
The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea. (22131607)
2011
17
Central sleep apnea. (20488284)
2010
18
Central sleep apnea indicates autonomic dysfunction in asymptomatic carotid stenosis: a potential marker of cerebrovascular and cardiovascular risk. (20337190)
2010
19
Impact of sleeping position on central sleep apnea/Cheyne-Stokes respiration in patients with heart failure. (20093078)
2010
20
"Awakenings": electrocardiographic findings in central sleep apnea. (20946562)
2010
21
Real-time dynamic carbon dioxide administration: a novel treatment strategy for stabilization of periodic breathing with potential application to central sleep apnea. (21087712)
2010
22
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
23
Effective treatment for idiopathic central sleep apnea? (19968045)
2009
24
Central sleep apnea and ataxia caused by brainstem lesion due to chronic neuroleptospirosis. (19949038)
2009
25
Valve repair improves central sleep apnea in heart failure patients with valvular heart diseases. (19713650)
2009
26
Central sleep apnea in a geriatric patient treated with aripiprazole. (19300045)
2009
27
Quality of life in patients with congestive heart failure and central sleep apnea. (18203661)
2008
28
Expression of TASK-1 in brainstem and the occurrence of central sleep apnea in rats. (18272437)
2008
29
Influence of thermal drive on central sleep apnea in the preterm neonate. (18457243)
2008
30
Impaired pulmonary diffusing capacity and hypoxia in heart failure correlates with central sleep apnea severity. (18198261)
2008
31
Causality in the relationship between central sleep apnea and paroxysmal atrial fibrillation. (17644474)
2008
32
Treating central sleep apnea in heart failure: outcomes revisited. (17592088)
2007
33
Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea: a preliminary study. (17400681)
2007
34
Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). (17562959)
2007
35
Central sleep apnea: Pathophysiology and treatment. (17296668)
2007
36
Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing. (17803007)
2007
37
CPAP should not be used for central sleep apnea in congestive heart failure patients. (17557466)
2006
38
Cardiac resynchronization therapy, central sleep apnea, and Cheyne-Stokes respiration in chronic heart failure patients. (15708718)
2005
39
Effect of CO2 inhalation on central sleep apnea and arousals from sleep. (15467327)
2004
40
Pembrey's dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. (12576341)
2003
41
Primary pulmonary hypertension with central sleep apnea: sudden death after bilevel positive airway pressure therapy. (10981861)
2000
42
Treatment of central sleep apnea in heart failure. (10893108)
2000
43
Article reviewed: A mechanism of central sleep apnea in patients with heart failure. (10733623)
2000
44
Central sleep apnea after interrupting longterm acetazolamide therapy. (9696283)
1998
45
Continuous versus bilevel positive airway pressure in a patient with idiopathic central sleep apnea. (9105099)
1997
46
Central sleep apnea-hypopnea syndrome in heart failure: prevalence, impact, and treatment. (9085518)
1996
47
Hypocapnia and increased ventilatory responsiveness in patients with idiopathic central sleep apnea. (8520761)
1995
48
Interaction of hyperventilation and arousal in the pathogenesis of idiopathic central sleep apnea. (8049835)
1994
49
Central sleep apnea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patients with acromegaly. (8049836)
1994
50
Successful treatment of central sleep apnea with an oral prosthesis. (1935315)
1991

Variations for Central Sleep Apnea

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Expression for genes affiliated with Central Sleep Apnea

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Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for genes affiliated with Central Sleep Apnea

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Pathways related to Central Sleep Apnea according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NPPB, NPPA
2
Show member pathways
9.6KCNK3, KCNK9
3
Show member pathways
Nicotine Activity on Dopaminergic Neurons36
9.6KCNK3, KCNK9
4
Show member pathways
9.1NOS3, KCNK3, KCNK9

Compounds for genes affiliated with Central Sleep Apnea

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Compounds related to Central Sleep Apnea according to GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1p000354310.1NPPA, NPPB
2hncs4310.1NPPB, NPPA
3candoxatril43 1211.1NPPB, NPPA
4alacepril4310.1NPPB, NPPA
5imidapril43 4911.1NPPA, NPPB
6urodilatin4310.1NPPB, NPPA
7hanp4310.1NPPA, NPPB
8bisoprolol43 49 1212.1NPPA, NPPB
9trandolapril43 1211.1NPPB, NPPA
10dobutamine43 28 49 1213.1NPPB, NPPA
11moxonidine4310.0NPPA, NPPB
12fosinopril43 1211.0NPPB, NPPA
13enalaprilat4310.0NPPB, NPPA
14celiprolol4310.0NOS3, NPPB
15tetraethylammonium chloride599.9KCNK9, KCNK3
16dmp 543599.9KCNK9, KCNK3
17lisinopril43 49 24 1212.9NPPB, NPPA
18bl 1249599.9KCNK3, KCNK9
19ys-035 hydrochloride599.9KCNK3, KCNK9
20nppb28 43 5911.9NPPA, NPPB
21isosorbide dinitrate43 49 1211.9NPPA, NOS3
22mibg439.9NPPB, NPPA
23ramipril43 1210.8NPPB, NPPA
24papaverine43 2 1211.8NPPB, NOS3
25metoprolol43 49 28 24 1213.6NPPB, NPPA, NOS3
26cesium chloride43 5910.6KCNK3, KCNK9
27perindopril43 49 1211.6NPPA, NOS3, NPPB
28amlodipine43 49 24 1212.6NPPB, NPPA, NOS3
29carvedilol43 49 28 1212.6NPPB, NOS3, NPPA
30sildenafil28 43 49 24 1213.6NPPB, NPPA, NOS3
31s-nitroso-n-acetylpenicillamine439.6NPPA, NPPB, NOS3
32nitroglycerin43 1210.6NPPA, NPPB, NOS3
33ang ii439.6NPPB, NOS3, NPPA
34guanylate439.6NOS3, NPPA, NPPB
35cgmp43 2810.5NPPA, NOS3, NPPB
36telmisartan43 28 1211.5LEP, NPPB
37losartan43 49 28 1212.5LEP, NPPB, NPPA
38kt 582343 2810.4NOS3, NPPA
39anandamide59 43 28 2412.4LEP, KCNK9, KCNK3
408-bromo cgmp439.4NPPA, NPPB
418-isoprostane439.4NPPB, NOS3, LEP
42pravastatin43 49 28 24 1213.4NPPB, NOS3, LEP
43rosiglitazone28 43 49 24 1213.4LEP, NOS3, NPPB
44glycerol43 24 1211.2LEP, NOS3, NPPA
45l-nmma439.0LEP, NPPA, NPPB, NOS3
46phenylephrine43 28 24 1212.0NPPA, LEP, NOS3, NPPB
47sodium nitroprusside439.0NPPB, NPPA, NOS3, LEP
48prostacyclin439.0NPPB, NPPA, LEP, NOS3
49vegf438.6NPPB, NOS3, NPPA, LEP
50arginine438.6NOS3, NPPA, LEP, NPPB, KCNK3

GO Terms for genes affiliated with Central Sleep Apnea

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Cellular components related to Central Sleep Apnea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.6NPPB, NPPA, IK, LEP

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00061829.8NPPA, NPPB
2receptor guanylyl cyclase signaling pathwayGO:00071689.8NPPB, NPPA
3cochlea developmentGO:00901029.6KCNK3, KCNK9
4ovulation from ovarian follicleGO:00015429.5NOS3, LEP
5female pregnancyGO:00075659.4NPPA, LEP
6regulation of blood vessel sizeGO:00508809.4NOS3, NPPA, NPPB
7potassium ion transportGO:00068139.3KCNK3, KCNK9
8response to insulinGO:00328689.3LEP, NPPA
9regulation of blood pressureGO:00082178.8NPPB, NPPA, NOS3, LEP

Molecular functions related to Central Sleep Apnea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1potassium channel activityGO:00052679.6KCNK3, KCNK9
2peptide hormone receptor bindingGO:00514289.1NPPA, LEP
3hormone activityGO:00051799.0NPPB, NPPA, LEP

Products for genes affiliated with Central Sleep Apnea

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Sources for Central Sleep Apnea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet