MCID: CNT015
MIFTS: 49

Central Sleep Apnea malady

Mental diseases, Neuronal diseases categories

Summaries for Central Sleep Apnea

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Disease Ontology:9 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary: Central Sleep Apnea, also known as central sleep apnea, primary, is related to congestive heart failure and primary pulmonary hypertension. An important gene associated with Central Sleep Apnea is NPPB (natriuretic peptide B), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Potassium transporters inward current. The compounds p00035 and hncs have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia:64 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Aliases & Classifications for Central Sleep Apnea

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Central Sleep Apnea, Aliases & Descriptions:

Name: Central Sleep Apnea 9 11
Central Sleep Apnea, Primary 61
 
Primary Central Sleep Apnea 9
Sleep Apnea, Central 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


External Ids:

Disease Ontology9 DOID:9220
ICD9CM28 327.21
MeSH34 D020182

Related Diseases for Central Sleep Apnea

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Diseases in the Central Sleep Apnea family:

Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure31.2NPPB, NPPA
2primary pulmonary hypertension30.7NPPB, NPPA
3pulmonary hypertension30.5NPPB, NPPA, NOS3
4hypertension30.1NPPB, NPPA, NOS3, LEP
5myocardial infarction30.0NPPB, NPPA, NOS3
6sleep apnea11.4
7obstructive sleep apnea10.6
8chiari malformation10.4
9mitral valve disease10.4NPPA
10sick sinus syndrome10.4NPPA
11dilated cardiomyopathy10.3
12pharyngitis10.3
13systolic heart failure10.3
14cerebritis10.3
15hypothyroidism10.3
16idiopathic alveolar hypoventilation syndrome10.3
17syndrome of inappropriate antidiuretic hormone10.2NPPA, NPPB
18mitral valve insufficiency10.2NPPA, NPPB
19mitral valve stenosis10.2NPPA, NPPB
20cor pulmonale10.2NPPA, NPPB
21heart valve disease10.2NPPA, NPPB
22hypertensive heart disease10.2NPPB, NPPA
23idiopathic edema10.2NPPA, NPPB
24aortic valve stenosis10.2NPPB, NPPA
25craniosynostosis10.2
26leukemia10.2
27obesity10.2
28acromegaly10.2
29leber hereditary optic neuropathy10.2
30carotid stenosis10.2
31hyperprolactinemia10.2
32joubert syndrome10.2
33cervicitis10.2
34esophagitis10.2
35neuropathy10.2
36sleep disorder10.2
37congenital central hypoventilation syndrome10.2
38chiari malformation type 110.2
39growth hormone deficiency10.2
40laryngomalacia10.2
41leptin deficiency10.2
42ataxia10.2
43autonomic dysfunction10.2
44hypoxia10.2
45central hypoventilation syndrome10.2
46blindness10.2
47eating disorder10.2LEP, NPPB
48congenital heart disease10.1NPPB, NPPA
49primary hyperoxaluria10.0LEP, NPPA
50septic shock9.9NPPB, NOS3

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to central sleep apnea

Symptoms for Central Sleep Apnea

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Drugs & Therapeutics for Central Sleep Apnea

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Drug clinical trials:

Search ClinicalTrials for Central Sleep Apnea

Search NIH Clinical Center for Central Sleep Apnea

Genetic Tests for Central Sleep Apnea

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Anatomical Context for Central Sleep Apnea

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MalaCards organs/tissues related to Central Sleep Apnea:

32
Heart, Brain, Testes, Tongue

Animal Models for Central Sleep Apnea or affiliated genes

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MGI Mouse Phenotypes related to Central Sleep Apnea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5NOS3, LEP, KCNK3, KCNK9
2MP:00053798.5NOS3, LEP, KCNK3, KCNK9
3MP:00053698.5LEP, NOS3, NPPA, NPPB
4MP:00036317.4KCNK9, KCNK3, LEP, NOTO, NOS3
5MP:00053857.0NPPB, KCNK9, KCNK3, LEP, NOTO, NOS3

Publications for Central Sleep Apnea

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Articles related to Central Sleep Apnea:

(show top 50)    (show all 229)
idTitleAuthorsYear
1
Effects of nocturnal oxygen therapy in patients with chronic heart failure and central sleep apnea: CHF-HOT study. (25348726)
2014
2
Left atrial size, chemosensitivity, and central sleep apnea in heart failure. (24522490)
2014
3
Adaptive servo-ventilation for the treatment of central sleep apnea in congestive heart failure: what have we learned? (25211247)
2014
4
Bradyarrhythmias may induce central sleep apnea in a patient with obstructive sleep apnea. (24748048)
2014
5
A novel therapeutic approach for the treatment of central sleep apnea: The remedA9Ar system. (24726495)
2014
6
Chiari 1 Malformation Presenting as Central Sleep Apnea during Pregnancy: A Case Report, Treatment Considerations, and Review of the Literature. (25386156)
2014
7
Positive airway pressure therapy in patients with opioid-related central sleep apnea. (24062011)
2013
8
Differential timing of arousals in obstructive and central sleep apnea in patients with heart failure. (23946707)
2013
9
Pearls & oy-sters: treatment of central sleep apnea with topiramate. (22508854)
2012
10
Treatment of central sleep apnea in U.S. veterans. (23066368)
2012
11
Central sleep apnea is a predictor of cardiac readmission in hospitalized patients with systolic heart failure. (22748486)
2012
12
Treatment of Cheyne-Stokes respiration-central sleep apnea in patients with heart failure. (22370166)
2012
13
Effectiveness of Adaptive Servo Ventilation in the treatment of hypocapnic central sleep apnea of various etiologies. (22030207)
2011
14
The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea. (22131607)
2011
15
Central sleep apnea. (20488284)
2010
16
Central sleep apnea indicates autonomic dysfunction in asymptomatic carotid stenosis: a potential marker of cerebrovascular and cardiovascular risk. (20337190)
2010
17
Impact of sleeping position on central sleep apnea/Cheyne-Stokes respiration in patients with heart failure. (20093078)
2010
18
Isolated central sleep apnea in type I Chiari malformation: improvement after surgery. (20848584)
2010
19
"Awakenings": electrocardiographic findings in central sleep apnea. (20946562)
2010
20
Real-time dynamic carbon dioxide administration: a novel treatment strategy for stabilization of periodic breathing with potential application to central sleep apnea. (21087712)
2010
21
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
22
Effective treatment for idiopathic central sleep apnea? (19968045)
2009
23
Central sleep apnea and ataxia caused by brainstem lesion due to chronic neuroleptospirosis. (19949038)
2009
24
Valve repair improves central sleep apnea in heart failure patients with valvular heart diseases. (19713650)
2009
25
Central sleep apnea in a geriatric patient treated with aripiprazole. (19300045)
2009
26
Quality of life in patients with congestive heart failure and central sleep apnea. (18203661)
2008
27
Expression of TASK-1 in brainstem and the occurrence of central sleep apnea in rats. (18272437)
2008
28
Influence of thermal drive on central sleep apnea in the preterm neonate. (18457243)
2008
29
Impaired pulmonary diffusing capacity and hypoxia in heart failure correlates with central sleep apnea severity. (18198261)
2008
30
Causality in the relationship between central sleep apnea and paroxysmal atrial fibrillation. (17644474)
2008
31
Treating central sleep apnea in heart failure: outcomes revisited. (17592088)
2007
32
Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea: a preliminary study. (17400681)
2007
33
Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). (17562959)
2007
34
Central sleep apnea: Pathophysiology and treatment. (17296668)
2007
35
Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing. (17803007)
2007
36
CPAP should not be used for central sleep apnea in congestive heart failure patients. (17557466)
2006
37
Cardiac resynchronization therapy, central sleep apnea, and Cheyne-Stokes respiration in chronic heart failure patients. (15708718)
2005
38
Effect of CO2 inhalation on central sleep apnea and arousals from sleep. (15467327)
2004
39
Pembrey's dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. (12576341)
2003
40
Primary pulmonary hypertension with central sleep apnea: sudden death after bilevel positive airway pressure therapy. (10981861)
2000
41
Treatment of central sleep apnea in heart failure. (10893108)
2000
42
Article reviewed: A mechanism of central sleep apnea in patients with heart failure. (10733623)
2000
43
Central sleep apnea after interrupting longterm acetazolamide therapy. (9696283)
1998
44
Effects of cardiac dysfunction on non-hypercapnic central sleep apnea. (9440576)
1998
45
Continuous versus bilevel positive airway pressure in a patient with idiopathic central sleep apnea. (9105099)
1997
46
Central sleep apnea-hypopnea syndrome in heart failure: prevalence, impact, and treatment. (9085518)
1996
47
Hypocapnia and increased ventilatory responsiveness in patients with idiopathic central sleep apnea. (8520761)
1995
48
Interaction of hyperventilation and arousal in the pathogenesis of idiopathic central sleep apnea. (8049835)
1994
49
Central sleep apnea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patients with acromegaly. (8049836)
1994
50
Successful treatment of central sleep apnea with an oral prosthesis. (1935315)
1991

Variations for Central Sleep Apnea

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Expression for genes affiliated with Central Sleep Apnea

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Expression patterns in normal tissues for genes affiliated with Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for genes affiliated with Central Sleep Apnea

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Pathways related to Central Sleep Apnea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NPPB, NPPA
29.6KCNK9, KCNK3
3
Show member pathways
9.6KCNK3, KCNK9
4
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
9.6KCNK3, KCNK9
5
Show member pathways
9.1NOS3, KCNK3, KCNK9

Compounds for genes affiliated with Central Sleep Apnea

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Compounds related to Central Sleep Apnea according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1p000354410.1NPPA, NPPB
2hncs4410.1NPPB, NPPA
3candoxatril44 1211.1NPPB, NPPA
4alacepril4410.1NPPB, NPPA
5imidapril44 5011.1NPPA, NPPB
6urodilatin4410.1NPPB, NPPA
7hanp4410.1NPPA, NPPB
8bisoprolol44 50 1212.1NPPA, NPPB
9trandolapril44 1211.1NPPB, NPPA
10dobutamine44 29 50 1213.1NPPB, NPPA
11moxonidine4410.0NPPA, NPPB
12fosinopril44 1211.0NPPB, NPPA
13enalaprilat4410.0NPPB, NPPA
14celiprolol4410.0NOS3, NPPB
15tetraethylammonium chloride609.9KCNK9, KCNK3
16dmp 543609.9KCNK9, KCNK3
17lisinopril44 50 25 1212.9NPPB, NPPA
18bl 1249609.9KCNK3, KCNK9
19ys-035 hydrochloride609.9KCNK3, KCNK9
20nppb29 44 6011.9NPPA, NPPB
21isosorbide dinitrate44 50 1211.9NPPA, NOS3
22mibg449.9NPPB, NPPA
23ramipril44 1210.8NPPB, NPPA
24papaverine44 3 1211.8NPPB, NOS3
25metoprolol44 50 29 25 1213.6NPPB, NPPA, NOS3
26cesium chloride44 6010.6KCNK3, KCNK9
27perindopril44 50 1211.6NPPA, NOS3, NPPB
28amlodipine44 50 25 1212.6NPPB, NPPA, NOS3
29carvedilol44 50 29 1212.6NPPB, NOS3, NPPA
30sildenafil29 44 50 25 1213.6NPPB, NPPA, NOS3
31s-nitroso-n-acetylpenicillamine449.6NPPA, NPPB, NOS3
32nitroglycerin44 1210.6NPPA, NPPB, NOS3
33ang ii449.6NPPB, NOS3, NPPA
34guanylate449.6NOS3, NPPA, NPPB
35cgmp44 2910.5NPPA, NOS3, NPPB
36telmisartan44 29 1211.5LEP, NPPB
37losartan44 50 29 1212.5LEP, NPPB, NPPA
38kt 582344 2910.4NOS3, NPPA
39anandamide60 44 29 2512.4LEP, KCNK9, KCNK3
408-bromo cgmp449.4NPPA, NPPB
418-isoprostane449.4NPPB, NOS3, LEP
42pravastatin44 50 29 25 1213.4NPPB, NOS3, LEP
43rosiglitazone29 44 50 25 1213.4LEP, NOS3, NPPB
44glycerol44 25 1211.2LEP, NOS3, NPPA
45l-nmma449.0LEP, NPPA, NPPB, NOS3
46phenylephrine44 29 25 1212.0NPPA, LEP, NOS3, NPPB
47sodium nitroprusside449.0NPPB, NPPA, NOS3, LEP
48prostacyclin449.0NPPB, NPPA, LEP, NOS3
49vegf448.6NPPB, NOS3, NPPA, LEP
50arginine448.6NOS3, NPPA, LEP, NPPB, KCNK3

GO Terms for genes affiliated with Central Sleep Apnea

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Cellular components related to Central Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6NPPB, NPPA, IK, LEP

Biological processes related to Central Sleep Apnea according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:0061829.8NPPA, NPPB
2receptor guanylyl cyclase signaling pathwayGO:0071689.8NPPB, NPPA
3cochlea developmentGO:0901029.6KCNK3, KCNK9
4ovulation from ovarian follicleGO:0015429.5NOS3, LEP
5female pregnancyGO:0075659.4NPPA, LEP
6regulation of blood vessel sizeGO:0508809.4NOS3, NPPA, NPPB
7potassium ion transportGO:0068139.3KCNK3, KCNK9
8response to insulinGO:0328689.3LEP, NPPA
9regulation of blood pressureGO:0082178.8NPPB, NPPA, NOS3, LEP

Molecular functions related to Central Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel activityGO:0052679.6KCNK3, KCNK9
2peptide hormone receptor bindingGO:0514289.1NPPA, LEP
3hormone activityGO:0051799.0NPPB, NPPA, LEP

Products for genes affiliated with Central Sleep Apnea

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Sources for Central Sleep Apnea

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet