MCID: CRB059
MIFTS: 37

Cerebellar Degeneration

Categories: Rare diseases, Neuronal diseases, Metabolic diseases

Aliases & Classifications for Cerebellar Degeneration

MalaCards integrated aliases for Cerebellar Degeneration:

Name: Cerebellar Degeneration 50 51 52 69

Classifications:



Summaries for Cerebellar Degeneration

NINDS : 51 Cerebellar degeneration is a process in which neurons (nerve cells) in the cerebellum - the area of the brain that controls coordination and balance - deteriorate and die. Diseases that cause cerebellar degeneration can also involve other areas of the central nervous system, including the spinal cord, medulla oblongata, cerebral cortex, and brain stem. Cerebellar degeneration may be the result of inherited genetic mutations that alter the normal production of specific proteins that are necessary for the survival of neurons.  In some cases the disease is aqauired (is non-hereditary or non-genetic). The most characteristic symptom of cerebellar degeneration is a wide-based, unsteady, lurching walk, often accompanied by a back and forth tremor in the trunk of the body. Other symptoms may include slow, unsteady and jerky movement of the arms or legs, slowed and slurred speech, and nystagmus -- rapid, small movements of the eyes. Associated diseases: Diseases that are specific to the brain, as well as diseases that occur in other parts of the body, can cause neurons to die in the cerebellum. Neurological diseases that feature cerebellar degeneration include: ischemic or hemorrhagic stroke, when there is lack of blood flow or oxygen to the cerebellum cerebellar cortical atrophy, multisystem atrophy, and olivopontocerebellar degeneration, progressive degenerative disorders in which cerebellar degeneration is a key feature Friedreich’s ataxia, and other spinocerebellar ataxias, which are caused by inherited genetic mutations that result in ongoing loss of neurons in the cerebellum, brain stem, and spinal cord transmissible spongiform encephalopathies (such as Creutzfeldt-Jakob disease) in which abnormal proteins cause inflammation in the brain, including the cerebellum multiple sclerosis, in which damage to the insulating membrane (myelin) that wraps around and protects nerve cells can involve the cerebellum Acquired diseases that can cause cerebellar degeneration include: chronic alcohol abuse that leads to temporary or permanent cerebellar damage paraneoplastic disorders, in which a malignancy (cancer) in other parts of the body produces substances that cause immune system cells to attack neurons in the cerebellum

MalaCards based summary : Cerebellar Degeneration is related to subacute cerebellar degeneration and paraneoplastic cerebellar degeneration. An important gene associated with Cerebellar Degeneration is CDR1 (Cerebellar Degeneration Related Protein 1), and among its related pathways/superpathways are ATM Pathway and BRCA1 Pathway. The drugs Riluzole and calcitonin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related phenotype is Synthetic lethal with MLN4924 (a NAE inhibitor).

NIH Rare Diseases : 50 cerebellar degeneration refers to the deterioration of neurons (nerve cells) in the cerebellum (the area of the brain that controls muscle coordination and balance). conditions that cause cerebellar degeneration may also affect other areas of the central nervous system, such as the spinal cord, the cerebral cortex (the thin layer of cells covering the brain), and the brain stem. signs and symptoms of cerebellar degeneration may include a wide-based, uncoordinated walk; a back and forth tremor in the trunk of the body; uncoordinated movements of the arms and legs; slow and slurred speech; and nystagmus. cerebellar degeneration can be caused by a variety of factors including inheritedgene changes (mutations), chronic alcohol abuse, and paraneoplastic disorders. treatment for cerebellar degeneration varies depending on the underlying cause. last updated: 12/14/2014

Related Diseases for Cerebellar Degeneration

Diseases in the Cerebellar Degeneration family:

Primary Cerebellar Degeneration Subacute Cerebellar Degeneration

Diseases related to Cerebellar Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
id Related Disease Score Top Affiliating Genes
1 subacute cerebellar degeneration 12.3
2 paraneoplastic cerebellar degeneration 12.3
3 ichthyosis, hepatosplenomegaly, and cerebellar degeneration 12.0
4 primary cerebellar degeneration 12.0
5 dykes markes harper syndrome 11.3
6 ataxia 11.1
7 paraneoplastic syndromes 11.0
8 infantile cerebellar-retinal degeneration 10.8
9 spinocerebellar ataxia 2 10.8
10 ataxia-telangiectasia-like disorder 1 10.7
11 menkes disease 10.7
12 familial hemiplegic migraine 10.7
13 paraneoplastic neurologic disorders 10.7
14 ataxias and cerebellar or spinocerebellar degeneration 10.7
15 spinocerebellar atrophy 10.7
16 spinocerebellar degeneration 10.7
17 neuronitis 10.1
18 adenocarcinoma 10.1
19 lymphoma 10.1
20 breast cancer 10.1
21 lambert-eaton myasthenic syndrome 10.1
22 lung cancer 10.0
23 prostatitis 9.9
24 tremor 9.9
25 hodgkin lymphoma 9.8
26 encephalitis 9.8
27 limbic encephalitis 9.8
28 cone-rod dystrophy 5 9.8 ATM CACNA1A
29 lambert syndrome 9.8
30 neuroleptic malignant syndrome 9.8
31 squamous cell carcinoma 9.8
32 prostate adenocarcinoma 9.8
33 fallopian tube adenocarcinoma 9.8
34 merkel cell carcinoma 9.8
35 neuropathy 9.8
36 idiopathic interstitial pneumonia 9.7 ATM CACNA1A
37 prostate carcinoma in situ 9.7 ATM CACNA1A
38 cerebellar ataxia 9.7
39 ataxia-telangiectasia 9.7
40 endometrial cancer 9.7
41 b-cell lymphomas 9.7
42 diffuse large b-cell lymphoma 9.7
43 severe combined immunodeficiency 9.7
44 nephrotic syndrome 9.7
45 dementia 9.7
46 diarrhea 9.7
47 ichthyosis 9.7
48 hypogonadism 9.7
49 neuroaxonal dystrophy 9.7
50 cerebritis 9.7

Graphical network of the top 20 diseases related to Cerebellar Degeneration:



Diseases related to Cerebellar Degeneration

Symptoms & Phenotypes for Cerebellar Degeneration

GenomeRNAi Phenotypes related to Cerebellar Degeneration according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 MRE11 ATM CDR2 CDR2L
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 MRE11 ATM CDR2 CDR2L

Drugs & Therapeutics for Cerebellar Degeneration

Drugs for Cerebellar Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Riluzole Approved, Investigational Phase 2, Phase 3 1744-22-5 5070
2 calcitonin Phase 3,Phase 2
3 Hormone Antagonists Phase 3,Phase 2
4 Hormones Phase 3,Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
6 Thyrotropin-Releasing Hormone Phase 3,Phase 2
7 Anticonvulsants Phase 2, Phase 3
8 Excitatory Amino Acid Antagonists Phase 2, Phase 3
9 Excitatory Amino Acids Phase 2, Phase 3
10 Neuroprotective Agents Phase 2, Phase 3
11 Neurotransmitter Agents Phase 2, Phase 3
12 Protective Agents Phase 2, Phase 3,Phase 1
13 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
14 Vaccines Phase 3
15 Antidepressive Agents Phase 2, Phase 3
16 Antimanic Agents Phase 2, Phase 3
17 Central Nervous System Depressants Phase 2, Phase 3
18 Lithium carbonate Phase 2, Phase 3 554-13-2
19 Psychotropic Drugs Phase 2, Phase 3
20 Tranquilizing Agents Phase 2, Phase 3
21
Varenicline Approved, Investigational Phase 2 249296-44-4 5310966
22
Dopamine Approved Phase 1, Phase 2 51-61-6, 62-31-7 681
23 Antibodies Phase 2
24 gamma-Globulins Phase 2
25 Immunoglobulins Phase 2
26 Immunoglobulins, Intravenous Phase 2
27 Rho(D) Immune Globulin Phase 2
28 Cholinergic Agents Phase 2
29 Nicotinic Agonists Phase 2
30 Dopamine Agents Phase 1, Phase 2
31 Dopamine agonists Phase 1, Phase 2
32 Calcium, Dietary Phase 2
33
Idebenone Approved, Investigational Phase 1 58186-27-9
34 Micronutrients Phase 1
35 Trace Elements Phase 1
36 Ubiquinone Phase 1
37 Vitamins Phase 1
38 Antioxidants Phase 1
39
Coenzyme Q10 Experimental, Nutraceutical Phase 1 303-98-0 5281915
40
Prednisone Approved, Vet_approved 53-03-2 5865
41
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
42 Calcineurin Inhibitors
43 Immunosuppressive Agents
44 Liver Extracts
45 Omega 3 Fatty Acid Nutraceutical

Interventional clinical trials:

(show all 49)

id Name Status NCT ID Phase Drugs
1 An Extension Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) Completed NCT01970111 Phase 3 KPS-0373, High dose;KPS-0373, Low dose
2 A Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) Completed NCT01970098 Phase 3 KPS-0373, High dose;KPS-0373, Low dose;Placebo
3 Efficacy of Riluzole in Hereditary Cerebellar Ataxia Completed NCT01104649 Phase 2, Phase 3 riluzole;Placebo comparator
4 Conjugate Pneumococcal Vaccine in Ataxia Telangiectasia (AT) Completed NCT00656409 Phase 3 Conjugated pneumococcal vaccine (Prevenar)
5 A Long-Term Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) Completed NCT01970124 Phase 3 KPS-0373, High dose;KPS-0373, Low dose
6 A 24-week Open-label Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) Completed NCT01970137 Phase 3 KPS-0373, High dose;KPS-0373, Low dose
7 Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3 Completed NCT01096082 Phase 2, Phase 3 Lithium Carbonate;Placebo
8 An Additional Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) Recruiting NCT02889302 Phase 3 KPS-0373;Placebo
9 A New Method to Treat Hereditary Cerebellar Ataxia - Umbilical Cord Mesenchymal Stem Cells Transplantation Unknown status NCT01489267 Phase 2
10 Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Hereditary Ataxia Unknown status NCT01360164 Phase 1, Phase 2
11 The Influence of Deep TMS on Cerebellar Signs in Patients With Machado Joseph Disease Unknown status NCT02039206 Phase 2
12 High-Dose Intravenous Immunoglobulin to Treat Cerebellar Degeneration Completed NCT00034242 Phase 2 high-dose intravenous immunoglobulin (IVIG)
13 Study to Determine the Safety and Tolerability of Varenicline (Chantix®) in Treating Spinocerebellar Ataxia Type 3 Completed NCT00992771 Phase 2 varenicline;placebo
14 A Trial of 18F-AV-133 and 18F-AV-45 Positron Emission Tomography (PET) Completed NCT01503944 Phase 1, Phase 2 18F-AV-133;18F-AV-45
15 Effect of Riluzole as a Symptomatic Approach in Patients With Chronic Cerebellar Ataxia Completed NCT00202397 Phase 2 Riluzole
16 A Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) Completed NCT01004016 Phase 2 KPS-0373;Placebo
17 Phase II Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) Completed NCT00863538 Phase 2 KPS-0373
18 A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) Completed NCT01384435 Phase 2 KPS-0373;KPS-0373;KPS-0373;KPS-0373;Placebo
19 Efficacy and Safety Study of Stemchymal® in Polyglutamine Spinocerebellar Ataxia Recruiting NCT02540655 Phase 2
20 Intravenous Levetiracetam as First-line Anticonvulsive Treatment in Patients With Non-convulsive Status Epilepticus Withdrawn NCT00603135 Phase 2 first-line i/v-levetiracetam
21 Natural History, Genetic Bases and Phenotype-genotype Correlations in Autosomal Dominant Spinocerebellar Degenerations Unknown status NCT00136630 Phase 1
22 Coenzyme Q10 in Adult-Onset Ataxia Completed NCT00957216 Phase 1 Placebo (sugar pill);Coenzyme Q10
23 Phase 1 Trial of Idebenone to Treat Patients With Friedreich's Ataxia Completed NCT00078481 Phase 1 Idebenone
24 Safety Study of Idebenone to Treat Friedreich's Ataxia Completed NCT00015808 Phase 1 Idebenone
25 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Tacrolimus
26 Emotional Communication Disorders in Cerebellar Disease Completed NCT02106819
27 Parkinsonism in Spinocerebellar Ataxia Type 6 Completed NCT01934998
28 Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia Completed NCT02103075
29 Coordination Training With Complete Body Video Games in Children and Adults With Degenerative Ataxias Completed NCT02874911
30 Biomarkers in Autosomal Dominant Cerebellar Ataxia Completed NCT01470729
31 Transcranial Magnetic Stimulation in Spino-Cerebellar Ataxia Completed NCT01975909
32 Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias Completed NCT01488461
33 The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria Completed NCT01983670
34 The Effect of Whole Body Vibration Training on Neuromuscular Property in Individuals With Ataxia Completed NCT01983631
35 Sporadic Degenerative Ataxia With Adult Onset: Natural History Study Recruiting NCT02701036
36 Longitudinal Monitoring of Energy Expenditure, Dynamic Stability and Fatigue During Gait in Patients With Cerebellar Ataxia Gene Recruiting NCT02903290
37 Gaze Holding in Cerebellar Patients Recruiting NCT02185313
38 PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA) Recruiting NCT02035761
39 Neural Mechanisms Engaged in Control of Eye Movements Recruiting NCT00999934
40 FA Clinical Outcome Measures Recruiting NCT03090789
41 The Motor Network in Essential Tremor: Mechanisms of Therapy Recruiting NCT02712515
42 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
43 The EUROSCA Natural History Study Recruiting NCT02440763
44 Clinical and Molecular Investigations Into Ciliopathies Recruiting NCT00068224
45 Machado-Joseph Disease in Israel Recruiting NCT02175290
46 Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia Active, not recruiting NCT03120013
47 Docosahexaenoic Acid (DHA) Replacement for Treatment in Spinocerebellar Ataxia 38 Active, not recruiting NCT03109626
48 Early and Longitudinal Assessment of Neurodegeneration in the Brain and Spinal Cord in Friedreich's Ataxia Enrolling by invitation NCT01776164
49 Brain Network Activation in Patients With Movement Disorders Not yet recruiting NCT03269201

Search NIH Clinical Center for Cerebellar Degeneration

Genetic Tests for Cerebellar Degeneration

Anatomical Context for Cerebellar Degeneration

MalaCards organs/tissues related to Cerebellar Degeneration:

39
Brain, Cortex, Spinal Cord, Cerebellum, Eye, Lung, Medulla Oblongata

Publications for Cerebellar Degeneration

Articles related to Cerebellar Degeneration:

(show top 50) (show all 566)
id Title Authors Year
1
A Rare Clinical Entity in Bladder Cancer: Paraneoplastic Cerebellar Degeneration. ( 28506560 )
2017
2
Impaired Feedforward Control and Enhanced Feedback Control of Speech in Patients with Cerebellar Degeneration. ( 28842410 )
2017
3
CAG repeat length does not associate with the rate of cerebellar degeneration in spinocerebellar ataxia type 3. ( 27942452 )
2017
4
Subacute Cerebellar Degeneration due to a Paraneoplastic Phenomenon Associated with Metastatic Merkel Cell Carcinoma: A Case Report. ( 28878663 )
2017
5
Paraneoplastic cerebellar degeneration associated with anti-ITPR1 antibodies. ( 28203616 )
2017
6
Cerebellar degeneration affects cortico-cortical connectivity in motor learning networks. ( 28761810 )
2017
7
Adult Onset Sporadic Cerebellar Ataxia in Singapore: Diagnostic Outcomes of Paraneoplastic Antibody Testing and Early Clinical Features of Paraneoplastic Cerebellar Degeneration. ( 28417137 )
2017
8
Paraneoplastic cerebellar degeneration in a patient with a primary fallopian tube adenocarcinoma. A case report and brief review. ( 28386581 )
2017
9
Cerebellar degeneration-related proteins 2 and 2-like are present in ovarian cancer in patients with and without Yo antibodies. ( 28710511 )
2017
10
Structural cerebellar correlates of cognitive and motor dysfunctions in cerebellar degeneration. ( 28043955 )
2017
11
Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration. ( 27957508 )
2017
12
Anti-Yo positive paraneoplastic cerebellar degeneration in the setting of cholangiocarcinoma. ( 27816258 )
2017
13
Permanent Cerebellar Degeneration After Acute Hyperthermia with Non-toxic Lithium Levels: a Case Report and Review of Literature. ( 28593454 )
2017
14
Anti-Yo positive and late-onset paraneoplastic cerebellar degeneration associated with ovarian carcinoma: A case report. ( 28796031 )
2017
15
Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer. ( 28377827 )
2017
16
Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms. ( 28886188 )
2017
17
Paraneoplastic Cerebellar Degeneration Associated with Pelvic Liposarcoma: A Rare Case Report. ( 28092914 )
2017
18
Paraneoplastic cerebellar degeneration secondary to ovarian carcinosarcoma: a cerebellar conundrum. ( 28790096 )
2017
19
Effects of transcranial direct current stimulation on grip force control in patients with cerebellar degeneration. ( 28932407 )
2017
20
Paraneoplastic cerebellar degeneration as a marker of endometrial cancer recurrence. ( 27194676 )
2016
21
Autoimmune neurological syndromes associated limbic encephalitis and paraneoplastic cerebellar degeneration. ( 27592059 )
2016
22
Paraneoplastic cerebellar degeneration with anti-Yo antibodies - a review. ( 27606347 )
2016
23
Hodgkin's lymphoma associated with paraneoplastic cerebellar degeneration in children: a case report and review of the literature. ( 27796550 )
2016
24
Restoring Balance: Paraneoplastic Cerebellar Degeneration. ( 27816447 )
2016
25
Voltage-Gated P/Q-Type Calcium Channel Antibodies Associated With Cerebellar Degeneration. ( 27436538 )
2016
26
A case of slowly progressive anti-Yo-associated paraneoplastic cerebellar degeneration successfully treated with antitumor and immunotherapy. ( 27356731 )
2016
27
Multiple System Atrophy Mistaken for Autoimmune Cerebellar Degeneration. ( 27107926 )
2016
28
Voltage-gated calcium channel autoimmune cerebellar degeneration: Case and study of cytotoxicity. ( 27088118 )
2016
29
Progressive cerebellar degeneration revealing Primary SjAPgren Syndrome: a case report. ( 27777786 )
2016
30
Smaller Absolute Quantities but Greater Relative Densities of Microvessels Are Associated with Cerebellar Degeneration in Lurcher Mice. ( 27147979 )
2016
31
Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenia in a patient with Merkel cell carcinoma and voltage-gated calcium channel antibodies. ( 28006860 )
2016
32
Paraneoplastic cerebellar degeneration and endometrial cancer: a rare occurrence. ( 27020505 )
2016
33
Paraneoplastic Cerebellar Degeneration-A Rare Presentation of Ovarian Malignancy. ( 27803545 )
2016
34
Years of Drinking but Not the Amount of Alcohol Intake Contribute to the Association Between Alcoholic Cerebellar Degeneration and Worse Cognitive Performance. A Population-Based Study. ( 27696290 )
2016
35
An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review. ( 27209351 )
2016
36
Anti-Ri antibody-mediated paraneoplastic cerebellar degeneration: A rare, treatable yet poorly recognized entity. ( 27625249 )
2016
37
Population-based study of alcoholic cerebellar degeneration: The Atahualpa Project. ( 27423619 )
2016
38
Alcohol-related cerebellar degeneration: not all down to toxicity? ( 27729985 )
2016
39
Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration. ( 26908626 )
2016
40
Secondary orthostatic tremor in the setting of cerebellar degeneration. ( 26765757 )
2016
41
A Rare Case of Ovarian Cancer Presenting with Paraneoplastic Cerebellar Degeneration and Limbic Encephalitis. ( 26415811 )
2015
42
JC virus granule cell neuronopathy: A cause of infectious cerebellar degeneration. ( 26003226 )
2015
43
Rapid Onset of Motor Deficits in a Mouse Model of Spinocerebellar Ataxia Type 6 Precedes Late Cerebellar Degeneration. ( 26730403 )
2015
44
Paraneoplastic cerebellar degeneration in a patient with ovarian cancer. ( 26166348 )
2015
45
Gaze holding deficits discriminate early from late onset cerebellar degeneration. ( 25980905 )
2015
46
Ataxin-3, DNA damage repair, and SCA3 cerebellar degeneration: on the path to parsimony? ( 25633989 )
2015
47
Paraneoplastic cerebellar degeneration and dermatomyositis as first manifestations of underlying breast malignancy: a report of two cases and a brief review of the subject. ( 26366356 )
2015
48
Anti-yo antibody uptake and interaction with its intracellular target antigen causes purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. ( 25885452 )
2015
49
Paraneoplastic cerebellar degeneration associated with small cell neuroendocrine mediastinal carcinoma. ( 26026691 )
2015
50
Early-stage Alcoholic Cerebellar Degeneration: Diagnostic Imaging Clues. ( 26848494 )
2015

Variations for Cerebellar Degeneration

Expression for Cerebellar Degeneration

Search GEO for disease gene expression data for Cerebellar Degeneration.

Pathways for Cerebellar Degeneration

Pathways related to Cerebellar Degeneration according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.34 ATM MRE11
2
Show member pathways
11.29 ATM MRE11
3 11.14 ATM MRE11
4 10.92 ATM MRE11
5 10.82 ATM MRE11
6 10.42 ATM MRE11
7
Show member pathways
9.83 ATM MRE11

GO Terms for Cerebellar Degeneration

Cellular components related to Cerebellar Degeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromosome, telomeric region GO:0000784 8.96 ATM MRE11
2 chromosome, telomeric region GO:0000781 8.62 ATM MRE11

Biological processes related to Cerebellar Degeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 double-strand break repair via homologous recombination GO:0000724 9.37 ATM MRE11
2 double-strand break repair via nonhomologous end joining GO:0006303 9.32 ATM MRE11
3 DNA synthesis involved in DNA repair GO:0000731 9.26 ATM MRE11
4 reciprocal meiotic recombination GO:0007131 9.16 ATM MRE11
5 strand displacement GO:0000732 8.96 ATM MRE11
6 DNA double-strand break processing GO:0000729 8.62 ATM MRE11

Sources for Cerebellar Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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