MCID: CRB059
MIFTS: 36

Cerebellar Degeneration malady

Summaries for Cerebellar Degeneration

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43NIH Rare Diseases, 44NINDS, 33MalaCards
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NIH Rare Diseases:43 Cerebellar degeneration is a disease process in which neurons in the cerebellum (the area of the brain that controls muscle coordination and balance) deteriorate and die. cerebellar degeneration does not constitute a specific diagnosis, but rather is used to describe the changes that occur in a person's nervous system. diseases that cause cerebellar degeneration can also involve areas of the brain that connect the cerebellum to the spinal cord, such as the medulla oblongata, the cerebral cortex, and the brain stem. cerebellar degeneration has many different causes, but is most often the result of inherited genetic mutations. last updated: 3/28/2011

MalaCards: Cerebellar Degeneration is related to paraneoplastic cerebellar degeneration and cerebellar degeneration, subacute. An important gene associated with Cerebellar Degeneration is CDR1 (cerebellar degeneration-related protein 1, 34kDa). The compounds alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and nmda have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and brain.

NINDS:44 Cerebellar degeneration is a process in which neurons in the cerebellum - the area of the brain that controls coordination and balance - deteriorate and die. Diseases that cause cerebellar degeneration can also involve other areas of the central nervous system,including the spinal cord, medulla oblongata, cerebral cortex, and brain stem. Cerebellar degeneration may be the result of inherited genetic mutations that alter the normal production of specific proteins that are necessary for the survival of neurons.

Aliases & Classifications for Cerebellar Degeneration

Sources:
43NIH Rare Diseases, 44NINDS, 45Novoseek, 61UMLS
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Aliases & Descriptions:

cerebellar degeneration 43 44 45 61


Related Diseases for Cerebellar Degeneration

Sources:
17GeneCards, 18GeneDecks
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Diseases in the primary cerebellar degeneration family:

cerebellar degeneration cerebellar degeneration, subacute

Diseases related to Cerebellar Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1paraneoplastic cerebellar degeneration31.7BLZF1, CDR2
2cerebellar degeneration, subacute10.7
3lambert syndrome10.5
4adenocarcinoma10.5
5lambert-eaton myasthenic syndrome10.5
6ataxia10.5
7primary cerebellar degeneration10.4
8n syndrome10.4
9dykes markes harper syndrome10.3
10paraneoplastic syndromes10.3
11neuroleptic malignant syndrome10.2
12bronchogenic carcinoma10.2
13squamous cell carcinoma10.2
14papillary carcinoma10.1
15ataxia telangiectasia10.1
16neuroaxonal dystrophy10.1
17spinocerebellar ataxia10.1
18spinocerebellar degeneration10.1
19limbic encephalitis10.1
20tremor10.1
21ovarian cancer10.0GRP, CDR2
22alzheimer's disease10.0BLZF1, CDR1, GSR, PRNP
23stomach cancer10.0GRP, LGALS4, BLZF1, PRNP
24lung cancer10.0GRP
25colorectal cancer10.0GRP, CA8, PKN1, LGALS4
26ipex syndrome10.0BLZF1, CDR1, MRE11A, LGALS4, PRNP
27parkinson's disease10.0
28marantic endocarditis10.0
29chediak-higashi syndrome10.0
30machado-joseph disease10.0
31neuroendocrine carcinoma10.0
32menkes disease10.0
33autoimmune thyroiditis10.0
34olivopontocerebellar atrophy10.0
35papillary renal cell carcinoma10.0
36essential tremor10.0
37pseudomyxoma peritonei10.0
38small cell carcinoma10.0
39familial hemiplegic migraine10.0
40gastric lymphoma10.0
41retinitis pigmentosa10.0
42relapsing-remitting multiple sclerosis10.0
43dentatorubral-pallidoluysian atrophy10.0
44hereditary spastic paraplegia10.0
45endometrial stromal sarcoma10.0
46mutism10.0
47lymphosarcoma10.0
48composite lymphoma10.0
49stiff-person syndrome10.0
50gastroesophageal junction adenocarcinoma10.0

Graphical network of the top 20 diseases related to Cerebellar Degeneration:



Diseases related to cerebellar degeneration

Clinical Features for Cerebellar Degeneration

Drugs & Therapeutics for Cerebellar Degeneration

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Cerebellar Degeneration

Drug clinical trials:

Search ClinicalTrials for Cerebellar Degeneration

Search NIH Clinical Center for Cerebellar Degeneration

Search CenterWatch for Cerebellar Degeneration

Genetic Tests for Cerebellar Degeneration

Anatomical Context for Cerebellar Degeneration

Sources:
33MalaCards
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MalaCards organs/tissues related to Cerebellar Degeneration:

33
Skin, Spinal cord, Brain, Lung, Uterus, Bone marrow, Whole blood, Cortex, Cerebellum, Smooth muscle, Small intestine, Colon, Thyroid, Breast, Prostate, Cervix, Tonsil, T cells, B cells, Fetal brain, Cerebellum peduncles, Medulla oblongata, Fetal lung, Fetal thyroid

Animal Models for Cerebellar Degeneration or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Cerebellar Degeneration

Sources:
51PubMed
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Articles related to Cerebellar Degeneration:

(show top 50)    (show all 528)
idTitleAuthorsYear
1
Progressive cerebellar atrophy: hereditary ataxias and disorders with spinocerebellar degeneration. (23622410)
2013
2
The Role of the Cerebellum in Dynamic Changes of the Sense of Body Ownership: A Study in Patients with Cerebellar Degeneration. (24236765)
2013
3
Magnetic resonance imaging and brainstem auditory evoked responses in the diagnosis of cerebellar cortical degeneration in american staffordshire terriers. (23439286)
2013
4
Acute Wallerian degeneration of middle cerebellar peduncles due to basilar artery thrombosis. (24082483)
2013
5
Paraneoplastic cerebellar degeneration caused by ovarian clear-cell carcinoma. (24148073)
2013
6
Gastric diffuse large B cell lymphoma presenting as paraneoplastic cerebellar degeneration: case report and review of literature. (24207096)
2013
7
Paraneoplastic cerebellar degeneration with anti-Yo antibodies associated with metastatic uveal melanoma. (24035275)
2013
8
Essential tremor with ubiquitinated intranuclear inclusions and cerebellar degeneration. (22551915)
2012
9
Unusual paraneoplastic syndromes of breast carcinoma: a combination of cerebellar degeneration and Lambert-Eaton Myasthenic Syndrome. (19005633)
2011
10
Selective cerebellar degeneration following carbon monoxide poisoning. (21163883)
2011
11
Paraneoplastic cerebellar degeneration mimicking development of secondary progressive multiple sclerosis in a patient with relapsing-remitting multiple sclerosis. (21148018)
2011
12
Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration. (22072678)
2011
13
Long-term efficiency of intravenously administered immunoglobulin in anti-Yo syndrome with paraneoplastic cerebellar degeneration. (21174114)
2011
14
Cerebellar degeneration as presenting symptom of recurrent endometrial stromal sarcoma with sex-cord elements. (21490714)
2011
15
Spongy degeneration with cerebellar ataxia in Malinois puppies: a hereditary autosomal recessive disorder? (21488963)
2011
16
Comparative study of cerebellar degeneration in canine neuroaxonal dystrophy, cerebellar cortical abiotrophy, and neuronal ceroid-lipofuscinosis. (20585192)
2010
17
Genetic interaction between the m-AAA protease isoenzymes reveals novel roles in cerebellar degeneration. (19289403)
2009
18
Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with adenocarcinoma of the gastroesophageal junction. (17785986)
2007
19
Timing of rhythmic movements in patients with cerebellar degeneration. (17786818)
2007
20
Cerebellar degeneration and immune thrombocytopenic purpura associated with human immunodeficiency virus infection (HIV). (18094865)
2007
21
Paraneoplastic cerebellar degeneration: new insights into imaging and immunology. (16543516)
2006
22
Cachexia--induced cerebellar degeneration: involvement of serum TNF and MCP-1 in the course of experimental neoplastic disease. (16886721)
2006
23
Frequency and clinicopathological characteristics of alcoholic cerebellar degeneration in Japan: a cross-sectional study of 1,509 postmortems. (16622656)
2006
24
Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma. (16929086)
2006
25
Paraneoplastic cerebellar degeneration in a woman with ovarian cancer. (16462852)
2006
26
An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies. (15081253)
2004
27
Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse. (15345707)
2004
28
Acute onset paraneoplastic cerebellar degeneration in a patient with small cell lung cancer. (14571014)
2003
29
Cerebellar degeneration and autoimmunity to zinc-finger proteins of the cerebellum. (12499499)
2002
30
Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with gastric adenocarcinoma. (11311295)
2001
31
Paraneoplastic cerebellar degeneration and Horner syndrome: association of two uncommon findings in a child with Hodgkin disease. (10779031)
2000
32
Muscle sympathetic activity in cerebellar degeneration with or without mild autonomic dysfunction. (10510684)
1999
33
Reduced intracortical facilitation in patients with cerebellar degeneration. (9858101)
1998
34
Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice. (9060410)
1997
35
Subacute cerebellar degeneration as a remote effect of breast cancer. (9833407)
1997
36
A new family of Boucher-NeuhAouser syndrome: coexistence of Holmes type cerebellar atrophy, hypogonadotropic hypogonadism and retinochoroidal degeneration: case reports and review of literature. (7670566)
1995
37
Passive transfer and active immunization with the recombinant leucine-zipper (Yo) protein as an attempt to establish an animal model of paraneoplastic cerebellar degeneration. (7707074)
1994
38
Selective cerebellar degeneration in a Limousin cross heifer. (8337803)
1993
39
Pursuing an occult carcinoma in a patient with subacute cerebellar degeneration and anticerebellar antibodies. Need for vigorous follow-up. (1536083)
1992
40
Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients. (1407575)
1992
41
Hereditary cerebellar degeneration with downbeat nystagmus. A case and it's treatment. (2375245)
1990
42
Word deafness syndrome with lateralized, progressive action myoclonus, epilepsy and cerebellar signs. Coexistence of multifocal and system, asymmetrical CNS degeneration. (2518575)
1989
43
Normal cerebellar glutamate dehydrogenase protein in spinocerebellar degeneration. (2732740)
1989
44
Hyperactive vestibulo-ocular reflex in cerebellar degeneration: pathogenesis and treatment. (3796839)
1987
45
The clinical versus radiological diagnosis of alcoholic cerebellar degeneration. (3701368)
1986
46
Severe cerebellar degeneration in a patient with T-cell lymphoma. (3485877)
1986
47
Skull structure with primary cerebellar degeneration. (7393452)
1980
48
Virus induced congenital anomalies of the bovine fetus. I. Cerebellar degeneration (hypoplasia), ocular lesions and fetal mummification following experimental infection with bovine viral diarrhea-mucosal disease virus. (4748881)
1973
49
A biochemic test for differential diagnosis between acanthocytosis and spino-cerebellar degenerations. (4185977)
1969
50
Cerebellar degeneration associated with chronic alcoholism. (5881777)
1965

Genetic Variations for Cerebellar Degeneration

Expression for genes affiliated with Cerebellar Degeneration

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebellar Degeneration

Search GEO for disease gene expression data for Cerebellar Degeneration.

Pathways for genes affiliated with Cerebellar Degeneration

Compounds for genes affiliated with Cerebellar Degeneration

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB, 11DrugBank
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Compounds related to Cerebellar Degeneration according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4510.3BLZF1, GSR
2nmda45 2911.1BLZF1, GRP, NRGN, GSR
3leucine459.9LGALS4, MORF4L1, PRNP, PKN1, BLZF1
4zinc45 2410.9ZIC1, BLZF1, PRNP, CA8, LGALS4
5genistein45 29 60 2 11 2414.8BLZF1, LGALS4, GSR, GRP
6tyrosine459.6BLZF1, MYBL2, PRNP, NRGN, PKN1, GRP
7arginine459.5MRE11A, BLZF1, GRP, PRNP, GSR

GO Terms for genes affiliated with Cerebellar Degeneration

Products for genes affiliated with Cerebellar Degeneration

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  • Proteins
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Sources for Cerebellar Degeneration

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet