MCID: CRB059
MIFTS: 29

Cerebellar Degeneration malady

Rare diseases, Metabolic diseases categories

Summaries for Cerebellar Degeneration

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NIH Rare Diseases:41 Cerebellar degeneration refers to the deterioration of neurons in the cerebellum (the area of the brain that controls muscle coordination and balance). conditions that cause cerebellar degeneration may also affect other areas of the central nervous system, such as the spinal cord, the cerebral cortex, and the brain stem. signs and symptoms of cerebellar degeneration may include a wide-based, uncoordinated walk; a back and forth tremor in the trunk of the body; uncoordinated movements of the arms and legs; slow and slurred speech; and nystagmus. cerebellar degeneration can be caused by a variety of factors including inherited gene changes (mutations), chronic alcohol abuse, and paraneoplastic disorders. treatment for cerebellar degeneration varies depending on the underlying cause. last updated: 12/14/2014

MalaCards based summary: Cerebellar Degeneration is related to paraneoplastic cerebellar degeneration and subacute cerebellar degeneration. An important gene associated with Cerebellar Degeneration is CDR1 (cerebellar degeneration-related protein 1, 34kDa). Affiliated tissues include brain, cortex and cerebellum, and related mouse phenotype behavior/neurological.

NINDS:42 Cerebellar degeneration is a process in which neurons in the cerebellum - the area of the brain that controls coordination and balance - deteriorate and die. Diseases that cause cerebellar degeneration can also involve other areas of the central nervous system,including the spinal cord, medulla oblongata, cerebral cortex, and brain stem. Cerebellar degeneration may be the result of inherited genetic mutations that alter the normal production of specific proteins that are necessary for the survival of neurons.

Aliases & Classifications for Cerebellar Degeneration

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Sources:
41NIH Rare Diseases, 42NINDS, 43Novoseek, 60UMLS
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Cerebellar Degeneration, Aliases & Descriptions:

Name: Cerebellar Degeneration 41 42 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Metabolic diseases


Related Diseases for Cerebellar Degeneration

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Diseases in the Cerebellar Degeneration family:

Primary Cerebellar Degeneration Subacute Cerebellar Degeneration

Diseases related to Cerebellar Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1paraneoplastic cerebellar degeneration11.2
2subacute cerebellar degeneration10.8
3neuronitis10.6
4adenocarcinoma10.6
5lambert-eaton myasthenic syndrome10.5
6breast cancer10.5
7ataxia10.5
8lung cancer10.4
9primary cerebellar degeneration10.4
10prostatitis10.4
11paraneoplastic syndromes10.4
12dykes markes harper syndrome10.3
13neuroleptic malignant syndrome10.2
14neuropathy10.2
15prostate adenocarcinoma10.2
16lambert syndrome10.2
17tremor10.2
18bronchogenic carcinoma10.2
19ataxia-telangiectasia10.1
20ataxia-telangiectasia-like disorder10.1
21hodgkin lymphoma10.1
22b-cell lymphomas10.1
23diffuse large b-cell lymphoma10.1
24severe combined immunodeficiency10.1
25neuroaxonal dystrophy10.1
26cerebritis10.1
27dementia10.1
28diarrhea10.1
29encephalitis10.1
30fallopian tube adenocarcinoma10.1
31hypogonadism10.1
32nephrotic syndrome10.1
33paraplegia10.1
34retinitis10.1
35limbic encephalitis10.1
36spasticity10.1
37schizophrenia10.0
38rheumatoid arthritis10.0
39prostate cancer10.0
40chediak-higashi syndrome10.0
41spinocerebellar ataxia 710.0
42machado-joseph disease10.0
43insulin-like growth factor i10.0
44abdominal obesity-metabolic syndrome 310.0
45kuru10.0
46infantile cerebellar-retinal degeneration10.0
47renal cell carcinoma10.0
48essential tremor10.0
49cerebellar ataxia10.0
50multiple myeloma10.0

Graphical network of the top 20 diseases related to Cerebellar Degeneration:



Diseases related to cerebellar degeneration

Symptoms for Cerebellar Degeneration

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Drugs & Therapeutics for Cerebellar Degeneration

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Drug clinical trials:

Search ClinicalTrials for Cerebellar Degeneration

Search NIH Clinical Center for Cerebellar Degeneration

Genetic Tests for Cerebellar Degeneration

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Anatomical Context for Cerebellar Degeneration

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MalaCards organs/tissues related to Cerebellar Degeneration:

31
Brain, Cortex, Cerebellum, Spinal cord, Medulla oblongata, Lung, Breast, T cells, Prostate, Eye, B cells, Skin, Uterus, Testes, Bone, Colon, Thyroid, Ovary, Cervix, Tonsil, Neutrophil

Animal Models for Cerebellar Degeneration or affiliated genes

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MGI Mouse Phenotypes related to Cerebellar Degeneration:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.5NRGN, CA8, ZIC1, MRE11A

Publications for Cerebellar Degeneration

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Articles related to Cerebellar Degeneration:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Surgical diagnosis of stage I fallopian tube cancer in anti-Yo antibody paraneoplastic cerebellar degeneration. (24960213)
2014
2
Cerebellar degeneration in Lurcher mice under confocal laser scanning microscope. (23463661)
2013
3
VGCC antibody-positive paraneoplastic cerebellar degeneration presenting with positioning vertigo. (21678073)
2011
4
Paraneoplastic cerebellar degeneration]. (20420175)
2010
5
Antineuronal autoantibodies in paraneoplastic cerebellar degeneration associated with adenocarcinoma of the prostate. (20089262)
2010
6
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (19581925)
2009
7
Genetic interaction between the m-AAA protease isoenzymes reveals novel roles in cerebellar degeneration. (19289403)
2009
8
Trace eyeblink conditioning in patients with cerebellar degeneration: comparison of short and long trace intervals. (18253726)
2008
9
Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with adenocarcinoma of the gastroesophageal junction. (17785986)
2007
10
Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion. (17494993)
2007
11
Autoimmune paraneoplastic cerebellar degeneration secondary to a composite lymphoma. (17613783)
2007
12
Endometrial carcinoma first presenting as paraneoplastic cerebellar degeneration. (17428523)
2007
13
Paraneoplastic cerebellar degeneration associated with anti-neuronal anti-Tr antibodies in a patient with Hodgkin's disease. (17065013)
2006
14
Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration. (16543536)
2006
15
A rare saccade velocity profile in Stiff-Person Syndrome with cerebellar degeneration. (16725126)
2006
16
Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma. (16361612)
2006
17
Translocation of cytochrome c during cerebellar degeneration in Lurcher and weaver mutant mice. (17113939)
2006
18
Strategies in detection of the primary tumour in anti-Yo associated paraneoplastic cerebellar degeneration. (15729526)
2005
19
Effect of a paraneoplastic cerebellar degeneration-associated neural protein on B-myb promoter activity. (15056460)
2004
20
Qualitative evidence of anti-Yo-specific intrathecal antibody synthesis in patients with paraneoplastic cerebellar degeneration. (12965268)
2003
21
Cerebellar degeneration and polyglandular autoimmune syndrome with anti-glutamic acid decarboxylase antibodies. (11993540)
2002
22
Anti-Ri-associated paraneoplastic cerebellar degeneration without opsoclonus in a patient with a neuroendocrine carcinoma of the stomach. (10826224)
2000
23
Cerebellar degeneration in Old English Sheepdogs. (11043686)
2000
24
Paraneoplastic cerebellar degeneration and Horner syndrome: association of two uncommon findings in a child with Hodgkin disease. (10779031)
2000
25
Positive response to therapy in a patient with a seropositive paraneoplastic cerebellar degeneration and an endometrioid carcinoma of the vesicovaginal septum. (10577031)
1999
26
Malignant gastric carcinoid and paraneoplastic cerebellar degeneration. (10636557)
1999
27
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration. (10208103)
1999
28
Purkinje cells in olivopontocerebellar atrophy and granule cell-type cerebellar degeneration: an immunohistochemical study. (9678515)
1998
29
A reversible neuronal antibody (anti-Tr) associated paraneoplastic cerebellar degeneration in Hodgkin's disease. (9858108)
1998
30
Study of hereditary cerebellar degeneration in cats. (8669758)
1996
31
On an autosomal dominant form of retinal-cerebellar degeneration: an autopsy study of five patients in one family. (7839819)
1994
32
Pursuing an occult carcinoma in a patient with subacute cerebellar degeneration and anticerebellar antibodies. Need for vigorous follow-up. (1536083)
1992
33
Hair trace elements in cerebellar degeneration: low copper levels in late cortical cerebellar atrophy. (2370563)
1990
34
Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literature concerning heat-related nervous system injury. (2647908)
1989
35
Antibodies to brain proteins in a patient with subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome. (3686524)
1987
36
Paraneoplastic cerebellar degeneration associated with Hodgkin's disease. (3430191)
1987
37
The clinical versus radiological diagnosis of alcoholic cerebellar degeneration. (3701368)
1986
38
Paraneoplastic cerebellar degeneration. A clinical and CT study. (6597869)
1984
39
Electroretinographic changes in a case of spino-cerebellar degeneration (SCD). (7206914)
1980
40
The remote effects of cancer on the nervous system: cerebellar degeneration. (889453)
1977
41
Virus induced congenital anomalies of the bovine fetus. I. Cerebellar degeneration (hypoplasia), ocular lesions and fetal mummification following experimental infection with bovine viral diarrhea-mucosal disease virus. (4748881)
1973
42
Cerebellar degeneration in thiamine-deficient rats. (4908519)
1970
43
Parenchymatous cerebellar degeneration associated with carcinoma of the lung. (5766463)
1969
44
Carcinomatous cerebellar degeneration, encephalomyelitis, and sensory neuropathy (radiculitis). Report of a case incorporating both purely degenerative and intense inflammatory changes, with special prominence of the latter in the putamen. (4306982)
1969
45
Cerebellar degeneration in association with carcinoma of the stomach. (5636744)
1968
46
A case of spino-cerebellar degeneration associated with carcinoma of the prostate. (6021237)
1967
47
Cerebellar degeneration associated with chronic alcoholism. (5937065)
1966
48
ALCOHOLIC CEREBELLAR DEGENERATION: A REPORT OF 3 CASES. (14327213)
1965
49
SUBACUTE CEREBELLAR DEGENERATION WITH HODGKIN'S DISEASE. (14055787)
1963
50
Subacute cerebellar degeneration associated with bronchogenic carcinoma. (13446743)
1957

Variations for Cerebellar Degeneration

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Expression for genes affiliated with Cerebellar Degeneration

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Search GEO for disease gene expression data for Cerebellar Degeneration.

Pathways for genes affiliated with Cerebellar Degeneration

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Compounds for genes affiliated with Cerebellar Degeneration

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GO Terms for genes affiliated with Cerebellar Degeneration

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Products for genes affiliated with Cerebellar Degeneration

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Sources for Cerebellar Degeneration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet