MCID: CRB059
MIFTS: 35

Cerebellar Degeneration malady

Rare diseases, Neuronal diseases, Metabolic diseases categories
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Summaries for Cerebellar Degeneration

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NIH Rare Diseases:42 Cerebellar degeneration is a disease process in which neurons in the cerebellum (the area of the brain that controls muscle coordination and balance) deteriorate and die. cerebellar degeneration does not constitute a specific diagnosis, but rather is used to describe the changes that occur in a person's nervous system. diseases that cause cerebellar degeneration can also involve areas of the brain that connect the cerebellum to the spinal cord, such as the medulla oblongata, the cerebral cortex, and the brain stem. cerebellar degeneration has many different causes, but is most often the result of inherited genetic mutations. last updated: 3/28/2011

MalaCards based summary: Cerebellar Degeneration is related to paraneoplastic cerebellar degeneration and subacute cerebellar degeneration. An important gene associated with Cerebellar Degeneration is CDR1 (cerebellar degeneration-related protein 1, 34kDa). Affiliated tissues include brain, cortex and cerebellum, and related mouse phenotype behavior/neurological.

NINDS:43 Cerebellar degeneration is a process in which neurons in the cerebellum - the area of the brain that controls coordination and balance - deteriorate and die. Diseases that cause cerebellar degeneration can also involve other areas of the central nervous system,including the spinal cord, medulla oblongata, cerebral cortex, and brain stem. Cerebellar degeneration may be the result of inherited genetic mutations that alter the normal production of specific proteins that are necessary for the survival of neurons.

Aliases & Classifications for Cerebellar Degeneration

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Sources:
42NIH Rare Diseases, 43NINDS, 44Novoseek, 62UMLS
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Cerebellar Degeneration, Aliases & Descriptions:

Name: Cerebellar Degeneration 42 43 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Metabolic diseases
Anatomical: Neuronal diseases


Related Diseases for Cerebellar Degeneration

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Diseases in the Subacute Cerebellar Degeneration family:

Primary Cerebellar Degeneration cerebellar degeneration

Diseases related to Cerebellar Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1paraneoplastic cerebellar degeneration11.2
2subacute cerebellar degeneration10.8
3neuronitis10.6
4adenocarcinoma10.5
5lambert-eaton myasthenic syndrome10.5
6ataxia10.5
7breast cancer10.5
8lung cancer10.4
9ovarian cancer10.4
10paraneoplastic syndromes10.4
11primary cerebellar degeneration10.4
12prostatitis10.4
13parkinson's disease10.3
14dykes markes harper syndrome10.3
15neuroleptic malignant syndrome10.2
16neuropathy10.2
17lambert syndrome10.2
18tremor10.2
19bronchogenic carcinoma10.2
20ataxia telangiectasia10.2
21b-cell lymphomas10.2
22diffuse large b-cell lymphoma10.2
23hodgkin's lymphoma10.2
24huntington's disease10.2
25severe combined immunodeficiency10.2
26neuroaxonal dystrophy10.2
27olivopontocerebellar atrophy10.2
28cerebritis10.2
29dementia10.2
30diarrhea10.2
31encephalitis10.2
32endometrial carcinoma10.2
33fallopian tube adenocarcinoma10.2
34hypogonadism10.2
35nephrotic syndrome10.2
36prostate adenocarcinoma10.2
37retinitis10.2
38spinocerebellar ataxia10.2
39spinocerebellar degeneration10.2
40limbic encephalitis10.2
41alzheimer's disease10.0
42arthritis10.0
43bipolar disorder10.0
44cerebellar ataxia10.0
45chediak-higashi syndrome10.0
46diabetes mellitus10.0
47follicular lymphoma10.0
48hereditary spastic paraplegia10.0
49hiv/aids10.0
50multiple myeloma10.0

Graphical network of the top 20 diseases related to Cerebellar Degeneration:



Diseases related to cerebellar degeneration

Symptoms for Cerebellar Degeneration

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Drugs & Therapeutics for Cerebellar Degeneration

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Drug clinical trials:

Search ClinicalTrials for Cerebellar Degeneration

Search NIH Clinical Center for Cerebellar Degeneration

Genetic Tests for Cerebellar Degeneration

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Anatomical Context for Cerebellar Degeneration

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MalaCards organs/tissues related to Cerebellar Degeneration:

32
Brain, Cortex, Cerebellum, Spinal cord, Medulla oblongata, Lung, Breast, T cells, Prostate, Eye, B cells, Skin, Uterus, Bone, Colon, Thyroid, Testes, Cervix, Tonsil, Neutrophil

Animal Models for Cerebellar Degeneration or affiliated genes

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MGI Mouse Phenotypes related to Cerebellar Degeneration:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.5NRGN, CA8, ZIC1, MRE11A

Publications for Cerebellar Degeneration

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Articles related to Cerebellar Degeneration:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Surgical diagnosis of stage I fallopian tube cancer in anti-Yo antibody paraneoplastic cerebellar degeneration. (24960213)
2014
2
Cerebellar degeneration in Lurcher mice under confocal laser scanning microscope. (23463661)
2013
3
VGCC antibody-positive paraneoplastic cerebellar degeneration presenting with positioning vertigo. (21678073)
2011
4
Paraneoplastic cerebellar degeneration]. (20420175)
2010
5
Antineuronal autoantibodies in paraneoplastic cerebellar degeneration associated with adenocarcinoma of the prostate. (20089262)
2010
6
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (19581925)
2009
7
Genetic interaction between the m-AAA protease isoenzymes reveals novel roles in cerebellar degeneration. (19289403)
2009
8
Trace eyeblink conditioning in patients with cerebellar degeneration: comparison of short and long trace intervals. (18253726)
2008
9
Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with adenocarcinoma of the gastroesophageal junction. (17785986)
2007
10
Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion. (17494993)
2007
11
Autoimmune paraneoplastic cerebellar degeneration secondary to a composite lymphoma. (17613783)
2007
12
Endometrial carcinoma first presenting as paraneoplastic cerebellar degeneration. (17428523)
2007
13
Paraneoplastic cerebellar degeneration associated with anti-neuronal anti-Tr antibodies in a patient with Hodgkin's disease. (17065013)
2006
14
Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration. (16543536)
2006
15
A rare saccade velocity profile in Stiff-Person Syndrome with cerebellar degeneration. (16725126)
2006
16
Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma. (16361612)
2006
17
Translocation of cytochrome c during cerebellar degeneration in Lurcher and weaver mutant mice. (17113939)
2006
18
Strategies in detection of the primary tumour in anti-Yo associated paraneoplastic cerebellar degeneration. (15729526)
2005
19
Effect of a paraneoplastic cerebellar degeneration-associated neural protein on B-myb promoter activity. (15056460)
2004
20
Qualitative evidence of anti-Yo-specific intrathecal antibody synthesis in patients with paraneoplastic cerebellar degeneration. (12965268)
2003
21
Cerebellar degeneration and polyglandular autoimmune syndrome with anti-glutamic acid decarboxylase antibodies. (11993540)
2002
22
Anti-Ri-associated paraneoplastic cerebellar degeneration without opsoclonus in a patient with a neuroendocrine carcinoma of the stomach. (10826224)
2000
23
Cerebellar degeneration in Old English Sheepdogs. (11043686)
2000
24
Paraneoplastic cerebellar degeneration and Horner syndrome: association of two uncommon findings in a child with Hodgkin disease. (10779031)
2000
25
Positive response to therapy in a patient with a seropositive paraneoplastic cerebellar degeneration and an endometrioid carcinoma of the vesicovaginal septum. (10577031)
1999
26
Malignant gastric carcinoid and paraneoplastic cerebellar degeneration. (10636557)
1999
27
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration. (10208103)
1999
28
Purkinje cells in olivopontocerebellar atrophy and granule cell-type cerebellar degeneration: an immunohistochemical study. (9678515)
1998
29
A reversible neuronal antibody (anti-Tr) associated paraneoplastic cerebellar degeneration in Hodgkin's disease. (9858108)
1998
30
Study of hereditary cerebellar degeneration in cats. (8669758)
1996
31
On an autosomal dominant form of retinal-cerebellar degeneration: an autopsy study of five patients in one family. (7839819)
1994
32
Pursuing an occult carcinoma in a patient with subacute cerebellar degeneration and anticerebellar antibodies. Need for vigorous follow-up. (1536083)
1992
33
Hair trace elements in cerebellar degeneration: low copper levels in late cortical cerebellar atrophy. (2370563)
1990
34
Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literature concerning heat-related nervous system injury. (2647908)
1989
35
Antibodies to brain proteins in a patient with subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome. (3686524)
1987
36
Paraneoplastic cerebellar degeneration associated with Hodgkin's disease. (3430191)
1987
37
The clinical versus radiological diagnosis of alcoholic cerebellar degeneration. (3701368)
1986
38
Paraneoplastic cerebellar degeneration. A clinical and CT study. (6597869)
1984
39
Electroretinographic changes in a case of spino-cerebellar degeneration (SCD). (7206914)
1980
40
The remote effects of cancer on the nervous system: cerebellar degeneration. (889453)
1977
41
Virus induced congenital anomalies of the bovine fetus. I. Cerebellar degeneration (hypoplasia), ocular lesions and fetal mummification following experimental infection with bovine viral diarrhea-mucosal disease virus. (4748881)
1973
42
Cerebellar degeneration in thiamine-deficient rats. (4908519)
1970
43
Parenchymatous cerebellar degeneration associated with carcinoma of the lung. (5766463)
1969
44
Carcinomatous cerebellar degeneration, encephalomyelitis, and sensory neuropathy (radiculitis). Report of a case incorporating both purely degenerative and intense inflammatory changes, with special prominence of the latter in the putamen. (4306982)
1969
45
Cerebellar degeneration in association with carcinoma of the stomach. (5636744)
1968
46
A case of spino-cerebellar degeneration associated with carcinoma of the prostate. (6021237)
1967
47
Cerebellar degeneration associated with chronic alcoholism. (5937065)
1966
48
ALCOHOLIC CEREBELLAR DEGENERATION: A REPORT OF 3 CASES. (14327213)
1965
49
SUBACUTE CEREBELLAR DEGENERATION WITH HODGKIN'S DISEASE. (14055787)
1963
50
Subacute cerebellar degeneration associated with bronchogenic carcinoma. (13446743)
1957

Variations for Cerebellar Degeneration

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Expression for genes affiliated with Cerebellar Degeneration

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Expression patterns in normal tissues for genes affiliated with Cerebellar Degeneration

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Pathways for genes affiliated with Cerebellar Degeneration

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Compounds for genes affiliated with Cerebellar Degeneration

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GO Terms for genes affiliated with Cerebellar Degeneration

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Products for genes affiliated with Cerebellar Degeneration

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  • Antibodies
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Sources for Cerebellar Degeneration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet