MCID: CRB059
MIFTS: 24

Cerebellar Degeneration malady

Summaries for Cerebellar Degeneration

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42NIH Rare Diseases, 43NINDS, 32MalaCards
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NIH Rare Diseases:42 Cerebellar degeneration is a disease process in which neurons in the cerebellum (the area of the brain that controls muscle coordination and balance) deteriorate and die. cerebellar degeneration does not constitute a specific diagnosis, but rather is used to describe the changes that occur in a person's nervous system. diseases that cause cerebellar degeneration can also involve areas of the brain that connect the cerebellum to the spinal cord, such as the medulla oblongata, the cerebral cortex, and the brain stem. cerebellar degeneration has many different causes, but is most often the result of inherited genetic mutations. last updated: 3/28/2011

MalaCards: Cerebellar Degeneration is related to breast cancer and lung cancer. An important gene associated with Cerebellar Degeneration is CDR1 (cerebellar degeneration-related protein 1, 34kDa). The compounds alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and nmda have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and cerebellum.

NINDS:43 Cerebellar degeneration is a process in which neurons in the cerebellum - the area of the brain that controls coordination and balance - deteriorate and die. Diseases that cause cerebellar degeneration can also involve other areas of the central nervous system,including the spinal cord, medulla oblongata, cerebral cortex, and brain stem. Cerebellar degeneration may be the result of inherited genetic mutations that alter the normal production of specific proteins that are necessary for the survival of neurons.

Aliases & Classifications for Cerebellar Degeneration

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42NIH Rare Diseases, 43NINDS, 44Novoseek, 60UMLS
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Aliases & Descriptions:

cerebellar degeneration 42 43 44 60


Related Diseases for Cerebellar Degeneration

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17GeneCards, 18GeneDecks
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Diseases in the Primary Cerebellar Degeneration family:

cerebellar degeneration Cerebellar Degeneration, Subacute

Diseases related to Cerebellar Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.6GSR, LGALS4, BLZF1, MYBL2, GRP, MRE11A
2lung cancer30.6GRP
3ovarian cancer30.5GRP, CDR2
4paraneoplastic cerebellar degeneration30.5BLZF1, CDR2
5cerebellar disease10.8
6neuronitis10.6
7adenocarcinoma10.5
8lambert-eaton myasthenic syndrome10.5
9cerebellar ataxia10.5
10primary cerebellar degeneration10.4
11prostatitis10.3
12parkinson's disease10.3
13cerebellar degeneration, subacute10.3
14dykes markes harper syndrome10.3
15neuroleptic malignant syndrome10.2
16bronchogenic carcinoma10.2
17hodgkin's lymphoma10.2
18lung squamous cell carcinoma10.2
19neuropathy10.2
20prostate adenocarcinoma10.2
21squamous cell carcinoma10.2
22papillary carcinoma10.1
23huntington's disease10.1
24ataxia telangiectasia10.1
25cerebritis10.1
26neuroaxonal dystrophy10.1
27cerebral degeneration10.1
28dementia10.1
29diarrhea10.1
30encephalitis10.1
31endometrial carcinoma10.1
32fallopian tube adenocarcinoma10.1
33movement disease10.1
34nephrotic syndrome10.1
35paraplegia10.1
36retinal degeneration10.1
37retinitis10.1
38severe combined immunodeficiency10.1
39spinocerebellar ataxia10.1
40spinocerebellar degeneration10.1
41alzheimer's disease10.0BLZF1, CDR1, GSR, PRNP
42stomach cancer10.0GRP, LGALS4, BLZF1, PRNP
43colorectal cancer10.0GRP, CA8, PKN1, LGALS4
44ipex syndrome10.0BLZF1, CDR1, MRE11A, LGALS4, PRNP
45marantic endocarditis10.0
46chediak-higashi syndrome10.0
47machado-joseph disease10.0
48neuroendocrine carcinoma10.0
49menkes disease10.0
50autoimmune thyroiditis10.0

Graphical network of the top 20 diseases related to Cerebellar Degeneration:



Diseases related to cerebellar degeneration

Clinical Features for Cerebellar Degeneration

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Drugs & Therapeutics for Cerebellar Degeneration

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebellar Degeneration

Drug clinical trials:

Search ClinicalTrials for Cerebellar Degeneration

Search NIH Clinical Center for Cerebellar Degeneration

Search CenterWatch for Cerebellar Degeneration

Genetic Tests for Cerebellar Degeneration

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Anatomical Context for Cerebellar Degeneration

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32MalaCards
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MalaCards organs/tissues related to Cerebellar Degeneration:

32
Spinal cord, Brain, Cerebellum, Cortex, Medulla oblongata

Animal Models for Cerebellar Degeneration or affiliated genes

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Publications for Cerebellar Degeneration

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Genetic Variations for Cerebellar Degeneration

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Expression for genes affiliated with Cerebellar Degeneration

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebellar Degeneration

Search GEO for disease gene expression data for Cerebellar Degeneration.

Pathways for genes affiliated with Cerebellar Degeneration

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Compounds for genes affiliated with Cerebellar Degeneration

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44Novoseek, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB, 11DrugBank
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Compounds related to Cerebellar Degeneration according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4410.3GSR, BLZF1
2nmda44 2811.1NRGN, GRP, BLZF1, GSR
3leucine449.9LGALS4, BLZF1, PKN1, PRNP, MORF4L1
4zinc44 2410.9LGALS4, BLZF1, PRNP, CA8, ZIC1
5genistein44 28 59 2 11 2414.8GSR, LGALS4, BLZF1, GRP
6tyrosine449.6PRNP, NRGN, PKN1, GRP, MYBL2, BLZF1
7arginine449.5MRE11A, PRNP, GRP, BLZF1, GSR

GO Terms for genes affiliated with Cerebellar Degeneration

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Products for genes affiliated with Cerebellar Degeneration

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebellar Degeneration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet