MCID: CRB059
MIFTS: 33

Cerebellar Degeneration malady

Rare diseases, Neuronal diseases categories
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Summaries for Cerebellar Degeneration

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43NIH Rare Diseases, 44NINDS, 33MalaCards
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NIH Rare Diseases:43 Cerebellar degeneration is a disease process in which neurons in the cerebellum (the area of the brain that controls muscle coordination and balance) deteriorate and die. cerebellar degeneration does not constitute a specific diagnosis, but rather is used to describe the changes that occur in a person's nervous system. diseases that cause cerebellar degeneration can also involve areas of the brain that connect the cerebellum to the spinal cord, such as the medulla oblongata, the cerebral cortex, and the brain stem. cerebellar degeneration has many different causes, but is most often the result of inherited genetic mutations. last updated: 3/28/2011

MalaCards: Cerebellar Degeneration is related to paraneoplastic cerebellar degeneration and neuronitis. An important gene associated with Cerebellar Degeneration is CDR1 (cerebellar degeneration-related protein 1, 34kDa). Affiliated tissues include brain, cortex and cerebellum, and related mouse phenotype behavior/neurological.

NINDS:44 Cerebellar degeneration is a process in which neurons in the cerebellum - the area of the brain that controls coordination and balance - deteriorate and die. Diseases that cause cerebellar degeneration can also involve other areas of the central nervous system,including the spinal cord, medulla oblongata, cerebral cortex, and brain stem. Cerebellar degeneration may be the result of inherited genetic mutations that alter the normal production of specific proteins that are necessary for the survival of neurons.

Aliases & Classifications for Cerebellar Degeneration

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43NIH Rare Diseases, 44NINDS, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

cerebellar degeneration 43 44 45 62


Related Diseases for Cerebellar Degeneration

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17GeneCards, 18GeneDecks
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Diseases in the Primary Cerebellar Degeneration family:

cerebellar degeneration Cerebellar Degeneration, Subacute

Diseases related to Cerebellar Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1paraneoplastic cerebellar degeneration11.2
2neuronitis10.6
3adenocarcinoma10.5
4ataxia10.5
5lambert-eaton myasthenic syndrome10.5
6breast cancer10.5
7lung cancer10.4
8ovarian cancer10.4
9primary cerebellar degeneration10.4
10prostatitis10.3
11paraneoplastic syndromes10.3
12parkinson's disease10.3
13cerebellar degeneration, subacute10.3
14dykes markes harper syndrome10.3
15bronchogenic carcinoma10.2
16neuroleptic malignant syndrome10.2
17hodgkin's lymphoma10.2
18neuropathy10.2
19lambert syndrome10.2
20neuroaxonal dystrophy10.1
21huntington's disease10.1
22ataxia telangiectasia10.1
23cerebritis10.1
24dementia10.1
25diarrhea10.1
26encephalitis10.1
27endometrial carcinoma10.1
28fallopian tube adenocarcinoma10.1
29nephrotic syndrome10.1
30paraplegia10.1
31prostate adenocarcinoma10.1
32retinitis10.1
33severe combined immunodeficiency10.1
34spinocerebellar ataxia10.1
35limbic encephalitis10.1
36spasticity10.1
37tremor10.1
38autoimmune thyroiditis10.0
39machado-joseph disease10.0
40chediak-higashi syndrome10.0
41marantic endocarditis10.0
42familial hemiplegic migraine10.0
43dentatorubral-pallidoluysian atrophy10.0
44follicular lymphoma10.0
45hereditary spastic paraplegia10.0
46relapsing-remitting multiple sclerosis10.0
47retinitis pigmentosa10.0
48kuru10.0
49endometrial stromal sarcoma10.0
50mutism10.0

Graphical network of the top 20 diseases related to Cerebellar Degeneration:



Diseases related to cerebellar degeneration

Symptoms for Cerebellar Degeneration

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Drugs & Therapeutics for Cerebellar Degeneration

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cerebellar Degeneration

Search NIH Clinical Center for Cerebellar Degeneration

Genetic Tests for Cerebellar Degeneration

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Anatomical Context for Cerebellar Degeneration

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33MalaCards
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MalaCards organs/tissues related to Cerebellar Degeneration:

33
Brain, Cortex, Cerebellum, Medulla oblongata, Spinal cord, Lung, T cells, Breast, Prostate, Eye, B cells, Skin, Uterus, Colon, Testes, Cervix, Tonsil, Bone, Thyroid

Animal Models for Cerebellar Degeneration or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cerebellar Degeneration:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.5NRGN, CA8, ZIC1, MRE11A

Publications for Cerebellar Degeneration

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52PubMed
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Articles related to Cerebellar Degeneration:

(show top 50)    (show all 476)
idTitleAuthorsYear
1
Cerebellar degeneration in Lurcher mice under confocal laser scanning microscope. (23463661)
2013
2
VGCC antibody-positive paraneoplastic cerebellar degeneration presenting with positioning vertigo. (21678073)
2011
3
Paraneoplastic cerebellar degeneration]. (20420175)
2010
4
Antineuronal autoantibodies in paraneoplastic cerebellar degeneration associated with adenocarcinoma of the prostate. (20089262)
2010
5
Hereditary cerebellar degeneration in Scottish terriers. (20384950)
2010
6
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (19581925)
2009
7
Genetic interaction between the m-AAA protease isoenzymes reveals novel roles in cerebellar degeneration. (19289403)
2009
8
Trace eyeblink conditioning in patients with cerebellar degeneration: comparison of short and long trace intervals. (18253726)
2008
9
Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion. (17494993)
2007
10
Autoimmune paraneoplastic cerebellar degeneration secondary to a composite lymphoma. (17613783)
2007
11
Endometrial carcinoma first presenting as paraneoplastic cerebellar degeneration. (17428523)
2007
12
Paraneoplastic cerebellar degeneration associated with anti-neuronal anti-Tr antibodies in a patient with Hodgkin's disease. (17065013)
2006
13
Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration. (16543536)
2006
14
A rare saccade velocity profile in Stiff-Person Syndrome with cerebellar degeneration. (16725126)
2006
15
Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma. (16361612)
2006
16
Translocation of cytochrome c during cerebellar degeneration in Lurcher and weaver mutant mice. (17113939)
2006
17
Strategies in detection of the primary tumour in anti-Yo associated paraneoplastic cerebellar degeneration. (15729526)
2005
18
Effect of a paraneoplastic cerebellar degeneration-associated neural protein on B-myb promoter activity. (15056460)
2004
19
Qualitative evidence of anti-Yo-specific intrathecal antibody synthesis in patients with paraneoplastic cerebellar degeneration. (12965268)
2003
20
Cerebellar degeneration and polyglandular autoimmune syndrome with anti-glutamic acid decarboxylase antibodies. (11993540)
2002
21
Cerebellar degeneration in Old English Sheepdogs. (11043686)
2000
22
Paraneoplastic cerebellar degeneration and Horner syndrome: association of two uncommon findings in a child with Hodgkin disease. (10779031)
2000
23
Positive response to therapy in a patient with a seropositive paraneoplastic cerebellar degeneration and an endometrioid carcinoma of the vesicovaginal septum. (10577031)
1999
24
Malignant gastric carcinoid and paraneoplastic cerebellar degeneration. (10636557)
1999
25
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration. (10208103)
1999
26
Purkinje cells in olivopontocerebellar atrophy and granule cell-type cerebellar degeneration: an immunohistochemical study. (9678515)
1998
27
A reversible neuronal antibody (anti-Tr) associated paraneoplastic cerebellar degeneration in Hodgkin's disease. (9858108)
1998
28
Study of hereditary cerebellar degeneration in cats. (8669758)
1996
29
On an autosomal dominant form of retinal-cerebellar degeneration: an autopsy study of five patients in one family. (7839819)
1994
30
Passive transfer and active immunization with the recombinant leucine-zipper (Yo) protein as an attempt to establish an animal model of paraneoplastic cerebellar degeneration. (7707074)
1994
31
Pursuing an occult carcinoma in a patient with subacute cerebellar degeneration and anticerebellar antibodies. Need for vigorous follow-up. (1536083)
1992
32
Hair trace elements in cerebellar degeneration: low copper levels in late cortical cerebellar atrophy. (2370563)
1990
33
Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literature concerning heat-related nervous system injury. (2647908)
1989
34
Paraneoplastic cerebellar degeneration associated with Hodgkin's disease. (3430191)
1987
35
The clinical versus radiological diagnosis of alcoholic cerebellar degeneration. (3701368)
1986
36
Paraneoplastic cerebellar degeneration. A clinical and CT study. (6597869)
1984
37
Combined acute necrotic myelopathy (ANM) and cerebellar degeneration associated with malignant disease. (6851302)
1983
38
Electroretinographic changes in a case of spino-cerebellar degeneration (SCD). (7206914)
1980
39
The remote effects of cancer on the nervous system: cerebellar degeneration. (889453)
1977
40
Virus induced congenital anomalies of the bovine fetus. I. Cerebellar degeneration (hypoplasia), ocular lesions and fetal mummification following experimental infection with bovine viral diarrhea-mucosal disease virus. (4748881)
1973
41
Cerebellar degeneration in thiamine-deficient rats. (4908519)
1970
42
Parenchymatous cerebellar degeneration associated with carcinoma of the lung. (5766463)
1969
43
Carcinomatous cerebellar degeneration, encephalomyelitis, and sensory neuropathy (radiculitis). Report of a case incorporating both purely degenerative and intense inflammatory changes, with special prominence of the latter in the putamen. (4306982)
1969
44
Cerebellar degeneration in association with carcinoma of the stomach. (5636744)
1968
45
A case of spino-cerebellar degeneration associated with carcinoma of the prostate. (6021237)
1967
46
Cerebellar degeneration associated with chronic alcoholism. (5937065)
1966
47
ALCOHOLIC CEREBELLAR DEGENERATION: A REPORT OF 3 CASES. (14327213)
1965
48
ARRESTED CEREBELLAR DEVELOPMENT: A TYPE OF CEREBELLAR DEGENERATION IN AMAUROTIC IDIOCY. (14123923)
1964
49
SUBACUTE CEREBELLAR DEGENERATION WITH HODGKIN'S DISEASE. (14055787)
1963
50
Subacute cerebellar degeneration associated with bronchogenic carcinoma. (13446743)
1957

Variations for Cerebellar Degeneration

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Expression for genes affiliated with Cerebellar Degeneration

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebellar Degeneration

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Pathways for genes affiliated with Cerebellar Degeneration

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Compounds for genes affiliated with Cerebellar Degeneration

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GO Terms for genes affiliated with Cerebellar Degeneration

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Products for genes affiliated with Cerebellar Degeneration

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Sources for Cerebellar Degeneration

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet