MCID: CRB027
MIFTS: 30

Cerebellar Disease malady

Summaries for Cerebellar Disease

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33MalaCards
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MalaCards: Cerebellar Disease, also known as cerebellar deficiency syndrome, is related to tremor and joubert syndrome. An important gene associated with Cerebellar Disease is NDUFA4 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa). Related mouse phenotype skeleton.

Aliases & Classifications for Cerebellar Disease

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

cerebellar disease 8
cerebellar deficiency syndrome 8
cerebellar dysfunction 45
cerebellar disorder 8
cerebellar diseases 61


External Ids:

Disease Ontology8 DOID:2786
MeSH35 D002526

Related Diseases for Cerebellar Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cerebellar Disease:



Diseases related to cerebellar disease

Clinical Features for Cerebellar Disease

Drugs & Therapeutics for Cerebellar Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Cerebellar Disease

Drug clinical trials:

Search ClinicalTrials for Cerebellar Disease

Search NIH Clinical Center for Cerebellar Disease

Search CenterWatch for Cerebellar Disease

Genetic Tests for Cerebellar Disease

Anatomical Context for Cerebellar Disease

Animal Models for Cerebellar Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Cerebellar Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.8ATXN7, PHF14, SATB2

Publications for Cerebellar Disease

Sources:
51PubMed
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Articles related to Cerebellar Disease:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
A rare cause of late-onset cerebellar ataxia: Erdheim-Chester disease. (23354540)
2013
2
Rituximab as potential therapy for paraneoplastic cerebellar degeneration in pediatric Hodgkin disease. (22532986)
2012
3
Factors influencing disease progression in autosomal dominant cerebellar ataxia and spastic paraplegia. (22491195)
2012
4
Cerebellar amyloid-I^ plaques: disturbed cortical circuitry in AI^PP/PS1 transgenic mice as a model of familial Alzheimer's disease. (22561329)
2012
5
Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration. (22072678)
2011
6
Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3. (21900579)
2011
7
Detecting bone marrow metastasis in cerebellar medulloblastoma: value of disease surveillance with FDG-PET in this setting. (21921346)
2011
8
Walking in circles: navigation deficits from Parkinson's disease but not from cerebellar ataxia. (21704129)
2011
9
Diffusion tensor imaging reveals disease-specific deep cerebellar nuclear changes in cerebellar degeneration. (20354716)
2010
10
Potential usefulness of D2R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases. (19002197)
2009
11
Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient. (19718409)
2009
12
Reduced saccadic resilience and impaired saccadic adaptation due to cerebellar disease. (18184318)
2008
13
A case of cerebral erdheim-chester disease with progressive cerebellar syndrome. (19513325)
2008
14
Time estimation in Parkinson's disease and degenerative cerebellar disease. (18580578)
2008
15
Recurrent audiovestibular disturbance initially mimicking MAcniA"re's disease in a patient with anterior inferior cerebellar infarction. (18941941)
2008
16
Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease. (18591368)
2008
17
Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies. (17404205)
2007
18
Morphological changes and prion accumulation in the cerebellar cortex in Creutzfeldt-Jacob disease]. (18290372)
2007
19
The Croonian Lectures On The Clinical Symptoms Of Cerebellar Disease And Their Interpretation. Lecture I. 1922. (17510914)
2007
20
Paraneoplastic syndrome: subacute cerebellar degeneration in Hodgkin's disease. (17454645)
2007
21
On autosomal dominant cerebellar ataxia (ADCA) other than polyglutamine diseases, with special reference to chromosome 16q22.1-linked ADCA. (16961073)
2006
22
Supervised learning of postural tasks in patients with poststroke hemiparesis, Parkinson's disease or cerebellar ataxia. (16175360)
2006
23
Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. (16112482)
2005
24
Subclinical celiac disease with cerebellar ataxia. (15508272)
2004
25
Cerebellar white matter involvement in Salla disease. (15179531)
2004
26
Cognitive impairments in cerebellar degeneration: a comparison with Huntington's disease. (15260369)
2004
27
The natural history of cerebellar hemangioblastomas in von Hippel-Lindau disease. (13679272)
2003
28
A fatal case of cerebellar hypoplasia associated with anterior horn cell disease. (12872823)
2003
29
Familial motor neurone disease with dementia: phenotypic variation and cerebellar pathology. (14617708)
2003
30
Paraneoplastic cerebellar degeneration and nephrotic syndrome preceding Hodgkin's disease: case report and review of the literature. (12144540)
2002
31
Medulloblastoma or cerebellar dysplastic gangliocytoma (Lhermitte-Duclos disease)? (12504212)
2002
32
Cerebellar-subcortical circuits and mania in cerebellar disease. (11207338)
2001
33
Effects of tetrahydrobiopterin on ataxia in Machado-Joseph disease may be based upon the theory of 'cerebellar long-term depression'. (11461169)
2001
34
Comorbid genetic diseases, von Hippel-Lindau disease and spinocerebellar ataxia type 2, confounding the diagnosis of cerebellar dysfunction in an adolescent. (11714564)
2001
35
Metastasis of renal carcinoma to a cerebellar hemangioblastoma in a patient with von Hippel Lindau disease: a case report. (10616572)
1999
36
Cerebellar astrocytoma associated with von Hippel-Lindau disease: case report with molecular findings. (10627785)
1999
37
Memory-guided saccadic eye movements: effects of cerebellar disease. (9893825)
1998
38
Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease. (9119979)
1997
39
Hereditary adult-onset Alexander's disease with palatal myoclonus, spastic paraparesis, and cerebellar ataxia. (8848205)
1995
40
The execution of bimanual movements in patients with Parkinson's, Huntington's and cerebellar disease. (8459247)
1993
41
Zinc deficiency and cerebellar disease. (1774146)
1991
42
Paraneoplastic subacute cerebellar degeneration in Hodgkin's disease. Report of three cases and review of the literature. (2555094)
1989
43
Control of isometric finger force in patients with cerebellar disease. (3179693)
1988
44
Tay-Sachs disease and normal cerebellar cells in culture: elevated levels of lysosomal enzymes in Tay-Sachs disease cells. (6816949)
1982
45
Glycolipids in cultured fetal Tay-Sachs disease cerebellar cells. (937117)
1976
46
Virus induced congenital anomalies of the bovine fetus. I. Cerebellar degeneration (hypoplasia), ocular lesions and fetal mummification following experimental infection with bovine viral diarrhea-mucosal disease virus. (4748881)
1973
47
SUBACUTE CEREBELLAR DEGENERATION WITH HODGKIN'S DISEASE. (14055787)
1963
48
Parenchymatous cortical cerebellar atrophy associated with Pick's disease. (20293596)
1947
49
Two Cases of Cerebellar Disease Followed by Autopsy. (18735985)
1913
50
On Some Clinical and Pathological Points in Cerebellar Disease. (20750924)
1884

Genetic Variations for Cerebellar Disease

Expression for genes affiliated with Cerebellar Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebellar Disease

Search GEO for disease gene expression data for Cerebellar Disease.

Pathways for genes affiliated with Cerebellar Disease

Compounds for genes affiliated with Cerebellar Disease

GO Terms for genes affiliated with Cerebellar Disease

Sources:
16Gene Ontology
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Cellular components related to Cerebellar Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear matrixGO:0163639.3ATXN7, SATB2

Molecular functions related to Cerebellar Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036829.3ATXN7, SATB2

Products for genes affiliated with Cerebellar Disease

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Sources for Cerebellar Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet