MCID: CRB029
MIFTS: 33

Cerebellopontine Angle Tumor malady

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebellopontine Angle Tumor

Aliases & Descriptions for Cerebellopontine Angle Tumor:

Name: Cerebellopontine Angle Tumor 12 14 69
Neoplasm of the Cerebellopontine Angle 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3200
NCIt 47 C5414

Summaries for Cerebellopontine Angle Tumor

MalaCards based summary : Cerebellopontine Angle Tumor, also known as neoplasm of the cerebellopontine angle, is related to acoustic neuroma and distal trisomy 10q. An important gene associated with Cerebellopontine Angle Tumor is SDHD (Succinate Dehydrogenase Complex Subunit D). The drugs Gentamicins and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and prostate, and related phenotypes are Increased proliferation and cellular

Related Diseases for Cerebellopontine Angle Tumor

Diseases related to Cerebellopontine Angle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Related Disease Score Top Affiliating Genes
1 acoustic neuroma 11.2
2 distal trisomy 10q 10.3 NF2 SMARCB1
3 thrombophlebitis 10.3 GFAP SMARCB1
4 bronchitis 10.3 GFAP NF2
5 trombiculiasis 10.3 GFAP SMARCB1
6 pediatric cns embryonal cell carcinoma 10.3 GFAP NF2
7 external ear disease 10.3 GFAP NF2
8 diabetes hypogonadism deafness mental retardation 10.3 GFAP SYP
9 brain stem ependymoma 10.3 GFAP SYP
10 intrahepatic bile duct adenoma 10.3 GFAP SYP
11 pilocytic astrocytoma of cerebellum 10.2 GFAP SYP
12 children's interstitial lung disease 10.2 GFAP SYP
13 cervical benign neoplasm 10.2 GFAP SYP
14 subglottic angioma 10.2 KANTR NF2
15 epidermal appendage tumor 10.2 GFAP SYP
16 diffuse pulmonary fibrosis 10.2 NF2 SAMHD1
17 microinvasive cervical squamous cell carcinoma 10.2 GFAP SYP
18 acral lentiginous melanoma 10.2 KANTR SAMHD1
19 intestinal pseudo-obstruction 10.2 GFAP SMARCB1
20 clear cell meningioma 10.2 GFAP SYP
21 porokeratosis 10.2 GFAP NF2
22 c-p angle neurinoma 10.2 GFAP NF2 SMARCB1
23 nephrogenic adenoma of urinary bladder 10.2 GFAP SYP
24 pineal dysgerminoma 10.2 GFAP JAG1 NF2
25 cerebral folate receptor alpha deficiency 10.2 GFAP SYP
26 mast-cell sarcoma 10.2 GFAP SMARCB1 SYP
27 olfactory neuroblastoma 10.2 GFAP SMARCB1 SYP
28 vulvar benign neoplasm 10.2 GFAP SYP
29 pineoblastoma 10.2 GFAP SMARCB1 SYP
30 brain stem astrocytic neoplasm 10.2 GFAP SMARCB1 SYP
31 papillary tumor of the pineal region 10.2 GFAP IDH1 SYP
32 pancreatic cancer 10.2 GFAP SMARCB1 SYP
33 temporal lobe neoplasm 10.2 GFAP SMARCB1 SYP
34 paternal uniparental disomy of chromosome 1 10.2 GFAP IDH1 SYP
35 adenofibroma 10.2 GFAP IDH1 SYP
36 clear cell variant infiltrating bladder urothelial carcinoma 10.2 GFAP SMARCB1 SYP
37 inner ear cancer 10.2 GFAP SMARCB1 SYP
38 childhood medulloblastoma 10.2 GFAP SMARCB1 SYP
39 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.2 GFAP IDH1 SYP
40 brain oligodendroglioma 10.2 GFAP IDH1 SYP
41 aneurysm of sinus of valsalva 10.2 GFAP NF2 SYP
42 childhood central nervous system primitive neuroectodermal neoplasm 10.2 GFAP IDH1 SYP
43 pleomorphic xanthoastrocytoma 10.2 GFAP NF2 SYP
44 endocrine organ benign neoplasm 10.2 NF2 SMARCB1 SYP
45 middle ear disease 10.2 GFAP IDH1
46 thoracic outlet syndrome 10.2 NF2 SMARCB1 SYP
47 early myoclonic encephalopathy 10.2 GFAP IDH1 SYP
48 breast squamous cell carcinoma 10.2 GFAP NF2 SYP
49 pilocytic astrocytoma 10.2 GFAP SYP
50 epimetaphyseal dysplasia cataract 10.2 GFAP NF2 SYP

Graphical network of the top 20 diseases related to Cerebellopontine Angle Tumor:



Diseases related to Cerebellopontine Angle Tumor

Symptoms & Phenotypes for Cerebellopontine Angle Tumor

GenomeRNAi Phenotypes related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Cerebellopontine Angle Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 CTSS ESR2 FKBP4 GFAP JAG1 RTEL1
2 growth/size/body region MP:0005378 9.65 IDH1 JAG1 NF2 RTEL1 SDHD SLC26A2
3 mortality/aging MP:0010768 9.36 ESR2 FKBP4 GFAP IDH1 JAG1 NF2

Drugs & Therapeutics for Cerebellopontine Angle Tumor

Drugs for Cerebellopontine Angle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Gentamicins Phase 4
2 Anti-Bacterial Agents Phase 4,Phase 2,Early Phase 1
3 Anti-Infective Agents Phase 4,Phase 2,Early Phase 1
4
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
6 Prednisolone acetate Phase 3
7 glucocorticoids Phase 3
8 Gastrointestinal Agents Phase 3
9 Neuroprotective Agents Phase 3
10 Hormone Antagonists Phase 3
11 Hormones Phase 3
12 Peripheral Nervous System Agents Phase 3,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
14 Prednisolone hemisuccinate Phase 3
15 Prednisolone phosphate Phase 3
16 Protective Agents Phase 3
17 Antiemetics Phase 3
18 Anti-Inflammatory Agents Phase 3,Phase 2
19 Methylprednisolone acetate Phase 3
20 Methylprednisolone Hemisuccinate Phase 3
21 Autonomic Agents Phase 3
22 Antineoplastic Agents, Hormonal Phase 3
23
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
24
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 6442177
25
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
26
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 5284616 6436030 46835353
27
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
28
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
29
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
30 Protein Kinase Inhibitors Phase 2,Early Phase 1
31 Endostatins Phase 2 71581480
32 Angiogenesis Inhibitors Phase 2,Phase 1
33 Angiogenesis Modulating Agents Phase 2,Phase 1
34 Immunoglobulins Phase 2
35 Antibodies, Monoclonal Phase 2
36 Immunosuppressive Agents Phase 2,Early Phase 1
37 Antifungal Agents Phase 2,Early Phase 1
38 Antibiotics, Antitubercular Phase 2,Early Phase 1
39 Antibodies Phase 2
40 Analgesics Phase 2
41 Cyclooxygenase Inhibitors Phase 2
42 Analgesics, Non-Narcotic Phase 2
43 Platelet Aggregation Inhibitors Phase 2
44 Fibrinolytic Agents Phase 2
45 Anti-Inflammatory Agents, Non-Steroidal Phase 2
46 Antipyretics Phase 2
47 Antirheumatic Agents Phase 2
48
Menthol Approved Early Phase 1 2216-51-5 16666
49 Natriuretic Agents
50 Coagulants

Interventional clinical trials:

(show all 43)
id Name Status NCT ID Phase
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Recruiting NCT02379754 Phase 4
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3
5 Vestibular Schwannoma - Radiosurgery or Expectation: V-REX. Recruiting NCT02249572 Phase 2, Phase 3
6 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
7 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2
8 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
9 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2
10 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2
11 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
12 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Recruiting NCT01345136 Phase 2
13 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT02129647 Phase 2
14 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
15 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2
16 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Recruiting NCT02934256 Phase 2
17 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Recruiting NCT02831257 Phase 2
18 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2
19 Study of Aspirin in Patients With Vestibular Schwannoma Not yet recruiting NCT03079999 Phase 2
20 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2
21 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1
22 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
23 Concentration and Activity of Lapatinib in Vestibular Schwannomas Unknown status NCT00863122 Early Phase 1
24 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231
25 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
26 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896
27 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
28 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216
29 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
30 A Family Study of Adults With Glioma Completed NCT00339352
31 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560
32 Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study Recruiting NCT01938677
33 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Recruiting NCT02275325
34 Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma Recruiting NCT02282917 Early Phase 1
35 Exploring the Activity of RAD001 in Vestibular Schwannomas and Meningiomas Recruiting NCT01880749 Early Phase 1
36 Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy Recruiting NCT01129687
37 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Recruiting NCT02811718
38 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Active, not recruiting NCT02309099
39 Natural History Study of Patients With Neurofibromatosis Type 2 Active, not recruiting NCT00598351
40 Response Prediction After GKS in Patients With Vestibular Schwannoma Using DCE MR Imaging Not yet recruiting NCT03097822
41 Evaluating the Pre-Positioning Frame for Robotic Acoustic Neuroma Removal Surgery Not yet recruiting NCT03057678
42 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Not yet recruiting NCT02948790
43 Hearing Handicap in Patients With Single Sided Deafness Withdrawn NCT02525640

Search NIH Clinical Center for Cerebellopontine Angle Tumor

Genetic Tests for Cerebellopontine Angle Tumor

Anatomical Context for Cerebellopontine Angle Tumor

MalaCards organs/tissues related to Cerebellopontine Angle Tumor:

39
Testes, Brain, Prostate, Salivary Gland

Publications for Cerebellopontine Angle Tumor

Articles related to Cerebellopontine Angle Tumor:

(show top 50) (show all 53)
id Title Authors Year
1
Symptomatic Trigeminal Neuralgia Caused by Cerebellopontine Angle Tumors. ( 28468211 )
2017
2
Early Nerve Grafting for Facial Paralysis After Cerebellopontine Angle Tumor Resection With Preserved Facial Nerve Continuity. ( 26584060 )
2016
3
Bilaterally Abnormal Head Impulse Tests Indicate a Large Cerebellopontine Angle Tumor. ( 26754780 )
2016
4
Effect of corticosteroids on facial function after cerebellopontine angle tumor removal: a double-blind study versus placebo. ( 25924803 )
2015
5
Clinical use of skull tap vestibular evoked myogenic potentials for the diagnoses of the cerebellopontine angle tumor patients. ( 24804198 )
2014
6
Transient cardiac asystole induced by electrocautery during excision of a cerebellopontine angle tumor. ( 24262476 )
2013
7
A 68-year old man with a cerebellopontine angle tumor. ( 23936919 )
2013
8
Bruns nystagmus in cerebellopontine angle tumor. ( 23552728 )
2013
9
Gamma Knife surgery for hemifacial spasm related to cerebellopontine angle tumors. ( 23205806 )
2012
10
Intraoperative Transcranial Motor-Evoked Potential Monitoring of the Facial Nerve during Cerebellopontine Angle Tumor Resection. ( 24083121 )
2012
11
Retrosigmoid approach to cerebellopontine angle tumor resection: surgical modifications. ( 22815095 )
2012
12
Necrotizing meningoencephalitis mimicking cerebellopontine angle tumor as late complication following cochlear implantation. ( 22340754 )
2012
13
Early complications and symptoms of cerebellopontine angle tumor surgery: a prospective analysis. ( 21373897 )
2011
14
Secondary trigeminal neuralgia in cerebellopontine angle tumors. ( 22451828 )
2011
15
Cerebellopontine angle tumors causing hemifacial spasm: types, incidence, and mechanism in nine reported cases and literature review. ( 20845049 )
2010
16
Microsurgical treatment for 55 patients with hemifacial spasm due to cerebellopontine angle tumors. ( 20217169 )
2010
17
A 47-year old male with a cerebellopontine angle tumor. ( 19744047 )
2009
18
Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor. ( 20436847 )
2009
19
Brain stem candidiasis mimicking cerebellopontine angle tumor. ( 18313733 )
2008
20
Cerebellopontine angle tumor in a patient with a maternally inherited SDHD gene mutation. ( 19205158 )
2008
21
Chemical meningitis following cerebellopontine angle tumor surgery. ( 18312887 )
2008
22
Hyperventilation-induced nystagmus in peripheral vestibulopathy and cerebellopontine angle tumor. ( 17785675 )
2007
23
Intraoperative monitoring of hearing during cerebellopontine angle tumor surgery using transtympanic electrocochleography. ( 17529854 )
2007
24
Unresponsiveness and pinpoint pupils after cerebellopontine angle tumor resection: opioid overdose versus postoperative hemorrhage. ( 16861457 )
2006
25
Bilateral sudden sensorineural hearing loss as a presentation of metastatic adenocarcinoma of unknown primary mimicking cerebellopontine angle tumor on the magnetic resonance image. ( 16500481 )
2006
26
Clinicoradiological review: symptomatic superior cerebellar artery aneurysm imitating cerebellopontine angle tumor. ( 15792523 )
2005
27
Approach design and closure techniques to minimize cerebrospinal fluid leak after cerebellopontine angle tumor surgery. ( 16272937 )
2005
28
Distal anterior inferior cerebellar artery aneurysm masquerading as a cerebellopontine angle tumor: case report and review of literature. ( 16145591 )
2004
29
Pain relief by stellate ganglion block in a case with trigeminal neuralgia caused by a cerebellopontine angle tumor. ( 15384297 )
2002
30
Endolymphatic sac tumor: a rare cerebellopontine angle tumor. ( 12577100 )
2002
31
Preoperative versus postoperative role of vestibular-evoked myogenic potentials in cerebellopontine angle tumor. ( 11889382 )
2002
32
Renal carcinoma metastasis: an unusual cerebellopontine angle tumor. ( 12297820 )
2002
33
Pathologic quiz case: an unusual cerebellopontine angle tumor. ( 11473473 )
2001
34
Cerebellopontine angle tumor composed of Schwann and meningeal proliferations. ( 11701080 )
2001
35
Neurosarcoidosis: An unusual case presenting as a cerebellopontine angle tumor. ( 10471878 )
1999
36
Evoked facial nerve EMG and brainstem auditory evoked potential monitoring in cerebellopontine angle tumor resection. ( 9407677 )
1997
37
Cerebellopontine angle tumor outcomes in patients with hazardous occupations. ( 9396673 )
1997
38
Sudden contralateral deafness following cerebellopontine angle tumor surgery. ( 8172310 )
1994
39
Hearing preservation in cerebellopontine angle tumor surgery: the NYU experience 1974-1991. ( 8122702 )
1993
40
Facial nerve repair techniques in cerebellopontine angle tumor surgery. ( 1415500 )
1992
41
The simultaneous use of electrocochleogram, brainstem auditory evoked potential and facial muscle EMG in cerebellopontine angle tumor removal. ( 1358342 )
1992
42
Cerebellar metastasis from prostatic carcinoma simulating, on CT-scan, a cerebellopontine angle tumor. Case report. ( 2718811 )
1989
43
Effects of cerebellar retraction on brainstem auditory evoked potentials in an experimental animal model of cerebellopontine angle tumor. ( 2784229 )
1989
44
Effects of cerebellar retraction on brainstem auditory evoked potentials in an experimental animal model of cerebellopontine angle tumor. ( 3257305 )
1988
45
Cerebellopontine angle tumor causing contralateral trigeminal neuralgia: a case report. ( 3497359 )
1987
46
Facial nerve function in cerebellopontine angle tumor surgery. ( 3878090 )
1985
47
Chronic granulomatous abscess simulating cerebellopontine angle tumor. ( 6435434 )
1984
48
Salivary gland heterotopia: a unique cerebellopontine angle tumor. ( 6274273 )
1982
49
Giant aneurysm of the anterior inferior cerebellar artery simulating a cerebellopontine angle tumor. ( 6981217 )
1982
50
Cerebellopontine angle tumor: diagnosis by oblique projection vertebral angiography. ( 310563 )
1979

Variations for Cerebellopontine Angle Tumor

Expression for Cerebellopontine Angle Tumor

Search GEO for disease gene expression data for Cerebellopontine Angle Tumor.

Pathways for Cerebellopontine Angle Tumor

GO Terms for Cerebellopontine Angle Tumor

Biological processes related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of double-strand break repair via homologous recombination GO:0010569 8.62 RTEL1 RTEL1-TNFRSF6B

Molecular functions related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0016818 8.62 RTEL1 RTEL1-TNFRSF6B

Sources for Cerebellopontine Angle Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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