MCID: CRB029
MIFTS: 38

Cerebellopontine Angle Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebellopontine Angle Tumor

MalaCards integrated aliases for Cerebellopontine Angle Tumor:

Name: Cerebellopontine Angle Tumor 12 14 69
Neoplasm of the Cerebellopontine Angle 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3200
NCIt 46 C5414
UMLS 69 C0474740

Summaries for Cerebellopontine Angle Tumor

MalaCards based summary : Cerebellopontine Angle Tumor, also known as neoplasm of the cerebellopontine angle, is related to facial paralysis and meningioma, familial. An important gene associated with Cerebellopontine Angle Tumor is SDHD (Succinate Dehydrogenase Complex Subunit D). The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and salivary gland, and related phenotypes are Increased proliferation and cellular

Related Diseases for Cerebellopontine Angle Tumor

Diseases related to Cerebellopontine Angle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 facial paralysis 30.0 KANTR NF2
2 meningioma, familial 29.9 GFAP NF2 SMARCB1 SYP
3 acoustic neuroma 11.4
4 monosomy 22 10.6 NF2 SMARCB1
5 schwannomatosis 1 10.5 NF2 SMARCB1
6 melanotic medulloblastoma 10.5 GFAP SMARCB1
7 cerebral convexity meningioma 10.5 GFAP NF2
8 intraventricular meningioma 10.5 GFAP NF2
9 cornea cancer 10.5 GFAP NF2
10 nodular medulloblastoma 10.5 GFAP SMARCB1
11 spinal cancer 10.4 GFAP NF2
12 optic nerve sheath meningioma 10.4 NF2 SAMHD1
13 chordoid glioma 10.4 GFAP NF2
14 mixed glioma 10.4 GFAP IDH1
15 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
16 lung combined type small cell carcinoma 10.4 GFAP SYP
17 plexiform schwannoma 10.4 GFAP NF2
18 cellular ependymoma 10.4 GFAP SYP
19 atypical neurofibroma 10.4 GFAP NF2
20 extraosseous chondrosarcoma 10.4 SMARCB1 SYP
21 gangliocytoma 10.4 GFAP SYP
22 pilomyxoid astrocytoma 10.4 GFAP SYP
23 cowden syndrome 3 10.4 ENSG00000255292 SDHD
24 foramen magnum meningioma 10.4 KANTR NF2
25 chordoid meningioma 10.4 GFAP SYP
26 central nervous system primitive neuroectodermal neoplasm 10.4 GFAP SYP
27 subependymal glioma 10.4 GFAP SYP
28 chiari malformation 10.4 GFAP SYP
29 neural crest tumor 10.4 ENSG00000255292 SDHD
30 cerebral neuroblastoma 10.4 GFAP SYP
31 paragangliomas 1 10.4 ENSG00000255292 SDHD
32 astroblastoma 10.4 GFAP SYP
33 malignant ependymoma 10.3 GFAP NF2
34 pineal gland cancer 10.3 GFAP SYP
35 neurilemmoma 10.3 GFAP NF2 SMARCB1
36 spinal cord ependymoma 10.3 GFAP JAG1 NF2
37 neuroma 10.3 GFAP NF2 SMARCB1
38 paraganglioma and gastric stromal sarcoma 10.3 ENSG00000255292 SDHD
39 melanotic neuroectodermal tumor 10.3 GFAP SYP
40 subependymoma 10.3 GFAP SYP
41 obstructive hydrocephalus 10.3 GFAP SYP
42 oculogyric crisis 10.3 JAG1 KANTR
43 accommodative esotropia 10.3 KANTR SAMHD1
44 fibrillary astrocytoma 10.3 GFAP IDH1
45 medulloepithelioma 10.3 GFAP SYP
46 progesterone resistance 10.3 ESR2 FKBP4
47 organ system benign neoplasm 10.3 NF2 SMARCB1 SYP
48 cerebral ventricle cancer 10.3 GFAP SMARCB1 SYP
49 cerebrum cancer 10.3 GFAP SMARCB1 SYP
50 supratentorial cancer 10.3 GFAP SMARCB1 SYP

Graphical network of the top 20 diseases related to Cerebellopontine Angle Tumor:



Diseases related to Cerebellopontine Angle Tumor

Symptoms & Phenotypes for Cerebellopontine Angle Tumor

GenomeRNAi Phenotypes related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Cerebellopontine Angle Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 CTSS ESR2 FKBP4 GFAP HEYL JAG1
2 growth/size/body region MP:0005378 10 ESR2 FKBP4 GFAP HEYL IDH1 JAG1
3 mortality/aging MP:0010768 9.93 IDH1 JAG1 NF2 RTEL1 SAMHD1 SDHD
4 muscle MP:0005369 9.5 GFAP HEYL JAG1 RTEL1 SMARCB1 CTSS
5 normal MP:0002873 9.23 ESR2 GFAP HEYL JAG1 RTEL1 SAMHD1

Drugs & Therapeutics for Cerebellopontine Angle Tumor

Drugs for Cerebellopontine Angle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 2,Early Phase 1
2 Anti-Infective Agents Phase 4,Phase 2,Early Phase 1
3 Gentamicins Phase 4
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6 Antiemetics Phase 3
7 Anti-Inflammatory Agents Phase 3,Phase 2
8 Antineoplastic Agents, Hormonal Phase 3
9 Autonomic Agents Phase 3
10 Gastrointestinal Agents Phase 3
11 glucocorticoids Phase 3
12 Hormone Antagonists Phase 3
13 Hormones Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
15 Methylprednisolone acetate Phase 3
16 Methylprednisolone Hemisuccinate Phase 3
17 Neuroprotective Agents Phase 3
18 Peripheral Nervous System Agents Phase 3,Phase 2
19 Prednisolone acetate Phase 3
20 Prednisolone hemisuccinate Phase 3
21 Prednisolone phosphate Phase 3
22 Protective Agents Phase 3
23
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
24
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 6442177
25
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
26
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 46835353 6436030 5284616
27
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
28
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
29
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
30 Protein Kinase Inhibitors Phase 2,Early Phase 1
31 Angiogenesis Inhibitors Phase 2,Phase 1
32 Angiogenesis Modulating Agents Phase 2,Phase 1
33 Antibodies Phase 2
34 Antibodies, Monoclonal Phase 2
35 Immunoglobulins Phase 2
36 Antibiotics, Antitubercular Phase 2,Early Phase 1
37 Antifungal Agents Phase 2,Early Phase 1
38 Immunosuppressive Agents Phase 2,Early Phase 1
39 Endostatins Phase 2 71581480
40 Analgesics Phase 2
41 Analgesics, Non-Narcotic Phase 2
42 Anti-Inflammatory Agents, Non-Steroidal Phase 2
43 Antipyretics Phase 2
44 Antirheumatic Agents Phase 2
45 Cyclooxygenase Inhibitors Phase 2
46 Fibrinolytic Agents Phase 2
47 Platelet Aggregation Inhibitors Phase 2
48
Menthol Approved Early Phase 1 2216-51-5 16666
49 Arginine Vasopressin
50 Coagulants

Interventional clinical trials:

(show all 48)

# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Recruiting NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4 Gentamicin
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
5 Vestibular Schwannoma - Radiosurgery or Expectation: V-REX. Recruiting NCT02249572 Phase 2, Phase 3
6 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
7 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
8 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2 RAD001
9 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2 Endostatin
10 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
11 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
12 RGD PET/MRI in Sporadic Vestibular Schwannoma Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
13 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT02129647 Phase 2 Axitinib
14 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
15 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
16 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Recruiting NCT02934256 Phase 2 Icotinib
17 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2 Bevacizumab
18 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
19 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Active, not recruiting NCT02831257 Phase 2 AZD2014
20 Study of Aspirin in Patients With Vestibular Schwannoma Not yet recruiting NCT03079999 Phase 2 Aspirin;Placebo
21 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
22 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
23 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
24 Concentration and Activity of Lapatinib in Vestibular Schwannomas Unknown status NCT00863122 Early Phase 1 lapatinib
25 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231
26 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
27 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896 gentamicin
28 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099
29 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
30 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216
31 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
32 A Family Study of Adults With Glioma Completed NCT00339352
33 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560
34 Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study Recruiting NCT01938677
35 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Recruiting NCT02275325
36 Vestibular Outcomes in Vestibular Schwannoma Recruiting NCT03346889
37 Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma Recruiting NCT02282917 Early Phase 1 AR-42
38 Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy Recruiting NCT01129687
39 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726
40 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Recruiting NCT02811718
41 Exploring the Activity of RAD001 in Vestibular Schwannomas and Meningiomas Active, not recruiting NCT01880749 Early Phase 1 RAD001
42 Natural History Study of Patients With Neurofibromatosis Type 2 Active, not recruiting NCT00598351
43 Response Prediction After GKS in Patients With Vestibular Schwannoma Using DCE MR Imaging Not yet recruiting NCT03097822
44 Evaluating the Pre-Positioning Frame for Robotic Acoustic Neuroma Removal Surgery Not yet recruiting NCT03057678
45 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Not yet recruiting NCT02948790
46 WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Not yet recruiting NCT03210285
47 Endoscopic-assisted Microsurgical Removal of Cerebellopontine Angle Lesions Not yet recruiting NCT03228511
48 Hearing Handicap in Patients With Single Sided Deafness Withdrawn NCT02525640

Search NIH Clinical Center for Cerebellopontine Angle Tumor

Genetic Tests for Cerebellopontine Angle Tumor

Anatomical Context for Cerebellopontine Angle Tumor

MalaCards organs/tissues related to Cerebellopontine Angle Tumor:

38
Brain, Testes, Salivary Gland, Prostate

Publications for Cerebellopontine Angle Tumor

Articles related to Cerebellopontine Angle Tumor:

(show top 50) (show all 56)
# Title Authors Year
1
Spontaneously Resolving Symptomatic Subdural Hygromas After Cerebellopontine Angle Tumor Surgery. ( 29101072 )
2018
2
The relation between flocculus volume and tinnitus after cerebellopontine angle tumor surgery. ( 29398141 )
2018
3
Focal hyperintensity in the dorsal brain stem of patients with cerebellopontine angle tumor: A high-resolution 3a88T MRI study. ( 29343821 )
2018
4
Symptomatic Trigeminal Neuralgia Caused by Cerebellopontine Angle Tumors. ( 28468211 )
2017
5
Early Nerve Grafting for Facial Paralysis After Cerebellopontine Angle Tumor Resection With Preserved Facial Nerve Continuity. ( 26584060 )
2016
6
Bilaterally Abnormal Head Impulse Tests Indicate a Large Cerebellopontine Angle Tumor. ( 26754780 )
2016
7
Effect of corticosteroids on facial function after cerebellopontine angle tumor removal: a double-blind study versus placebo. ( 25924803 )
2015
8
Clinical use of skull tap vestibular evoked myogenic potentials for the diagnoses of the cerebellopontine angle tumor patients. ( 24804198 )
2014
9
Bruns nystagmus in cerebellopontine angle tumor. ( 23552728 )
2013
10
A 68-year old man with a cerebellopontine angle tumor. ( 23936919 )
2013
11
Transient cardiac asystole induced by electrocautery during excision of a cerebellopontine angle tumor. ( 24262476 )
2013
12
Retrosigmoid approach to cerebellopontine angle tumor resection: surgical modifications. ( 22815095 )
2012
13
Intraoperative Transcranial Motor-Evoked Potential Monitoring of the Facial Nerve during Cerebellopontine Angle Tumor Resection. ( 24083121 )
2012
14
Necrotizing meningoencephalitis mimicking cerebellopontine angle tumor as late complication following cochlear implantation. ( 22340754 )
2012
15
Gamma Knife surgery for hemifacial spasm related to cerebellopontine angle tumors. ( 23205806 )
2012
16
Secondary trigeminal neuralgia in cerebellopontine angle tumors. ( 22451828 )
2011
17
Early complications and symptoms of cerebellopontine angle tumor surgery: a prospective analysis. ( 21373897 )
2011
18
Microsurgical treatment for 55 patients with hemifacial spasm due to cerebellopontine angle tumors. ( 20217169 )
2010
19
Cerebellopontine angle tumors causing hemifacial spasm: types, incidence, and mechanism in nine reported cases and literature review. ( 20845049 )
2010
20
Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor. ( 20436847 )
2009
21
A 47-year old male with a cerebellopontine angle tumor. ( 19744047 )
2009
22
Chemical meningitis following cerebellopontine angle tumor surgery. ( 18312887 )
2008
23
Cerebellopontine angle tumor in a patient with a maternally inherited SDHD gene mutation. ( 19205158 )
2008
24
Brain stem candidiasis mimicking cerebellopontine angle tumor. ( 18313733 )
2008
25
Hyperventilation-induced nystagmus in peripheral vestibulopathy and cerebellopontine angle tumor. ( 17785675 )
2007
26
Intraoperative monitoring of hearing during cerebellopontine angle tumor surgery using transtympanic electrocochleography. ( 17529854 )
2007
27
Unresponsiveness and pinpoint pupils after cerebellopontine angle tumor resection: opioid overdose versus postoperative hemorrhage. ( 16861457 )
2006
28
Bilateral sudden sensorineural hearing loss as a presentation of metastatic adenocarcinoma of unknown primary mimicking cerebellopontine angle tumor on the magnetic resonance image. ( 16500481 )
2006
29
Approach design and closure techniques to minimize cerebrospinal fluid leak after cerebellopontine angle tumor surgery. ( 16272937 )
2005
30
Clinicoradiological review: symptomatic superior cerebellar artery aneurysm imitating cerebellopontine angle tumor. ( 15792523 )
2005
31
Distal anterior inferior cerebellar artery aneurysm masquerading as a cerebellopontine angle tumor: case report and review of literature. ( 16145591 )
2004
32
Preoperative versus postoperative role of vestibular-evoked myogenic potentials in cerebellopontine angle tumor. ( 11889382 )
2002
33
Pain relief by stellate ganglion block in a case with trigeminal neuralgia caused by a cerebellopontine angle tumor. ( 15384297 )
2002
34
Renal carcinoma metastasis: an unusual cerebellopontine angle tumor. ( 12297820 )
2002
35
Endolymphatic sac tumor: a rare cerebellopontine angle tumor. ( 12577100 )
2002
36
Pathologic quiz case: an unusual cerebellopontine angle tumor. ( 11473473 )
2001
37
Cerebellopontine angle tumor composed of Schwann and meningeal proliferations. ( 11701080 )
2001
38
Neurosarcoidosis: An unusual case presenting as a cerebellopontine angle tumor. ( 10471878 )
1999
39
Cerebellopontine angle tumor outcomes in patients with hazardous occupations. ( 9396673 )
1997
40
Evoked facial nerve EMG and brainstem auditory evoked potential monitoring in cerebellopontine angle tumor resection. ( 9407677 )
1997
41
Sudden contralateral deafness following cerebellopontine angle tumor surgery. ( 8172310 )
1994
42
Hearing preservation in cerebellopontine angle tumor surgery: the NYU experience 1974-1991. ( 8122702 )
1993
43
Facial nerve repair techniques in cerebellopontine angle tumor surgery. ( 1415500 )
1992
44
The simultaneous use of electrocochleogram, brainstem auditory evoked potential and facial muscle EMG in cerebellopontine angle tumor removal. ( 1358342 )
1992
45
Effects of cerebellar retraction on brainstem auditory evoked potentials in an experimental animal model of cerebellopontine angle tumor. ( 2784229 )
1989
46
Cerebellar metastasis from prostatic carcinoma simulating, on CT-scan, a cerebellopontine angle tumor. Case report. ( 2718811 )
1989
47
Effects of cerebellar retraction on brainstem auditory evoked potentials in an experimental animal model of cerebellopontine angle tumor. ( 3257305 )
1988
48
Cerebellopontine angle tumor causing contralateral trigeminal neuralgia: a case report. ( 3497359 )
1987
49
Facial nerve function in cerebellopontine angle tumor surgery. ( 3878090 )
1985
50
Chronic granulomatous abscess simulating cerebellopontine angle tumor. ( 6435434 )
1984

Variations for Cerebellopontine Angle Tumor

Expression for Cerebellopontine Angle Tumor

Search GEO for disease gene expression data for Cerebellopontine Angle Tumor.

Pathways for Cerebellopontine Angle Tumor

GO Terms for Cerebellopontine Angle Tumor

Cellular components related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial envelope GO:0005740 8.96 ENSG00000255292 SDHD
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 ENSG00000255292 SDHD

Biological processes related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pulmonary valve morphogenesis GO:0003184 9.16 HEYL JAG1
2 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.96 ENSG00000255292 SDHD
3 tricarboxylic acid cycle GO:0006099 8.8 ENSG00000255292 IDH1 SDHD

Molecular functions related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 8.96 ENSG00000255292 SDHD
2 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 ENSG00000255292 SDHD

Sources for Cerebellopontine Angle Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....