AMYL6
MCID: CRB019
MIFTS: 58

Cerebral Amyloid Angiopathy (AMYL6) malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases, Neuronal diseases, Bone diseases, Metabolic diseases

Aliases & Classifications for Cerebral Amyloid Angiopathy

Aliases & Descriptions for Cerebral Amyloid Angiopathy:

Name: Cerebral Amyloid Angiopathy 54 12 50 66 29 13 52 14 69
Hereditary Cerebral Hemorrhage with Amyloidosis 50 24 56 66
Hchwa 50 24 56 66
Hereditary Cystatin C Amyloid Angiopathy 56 66 69
Cerebral Amyloid Angiopathy, Familial 50 42
Hereditary Cerebral Hemorrhage with Amyloidosis, Icelandic Type 56
Hereditary Cerebral Hemorrhage with Amyloidosis Icelandic Type 66
Hereditary Cerebral Haemorrhage with Amyloidosis - Dutch Type 12
Hereditary Cerebral Amyloid Angiopathy, Icelandic Type 69
Cerebral Hemorrhage, Hereditary with Amyloidosis 24
Dutch Hereditary Cerebral Amyloid Angiopathy 12
Amyloidosis, Cerebroarterial, Icelandic Type 24
Cerebroarterial Amyloidosis Icelandic Type 66
Cerebral Amyloid Angiopathy, Cst3-Related 54
Cst3-Related Cerebral Amyloid Angiopathy 24
Cerebral Amyloid Angiopathy Cst3-Related 66
Cerebral Amyloid Angiopathy, Hereditary 69
Cerebral Amyloid Angiopathy, Genetic 50
Familial Cerebral Amyloid Angiopathy 69
Cst3-Related Amyloidosis 56
Cystatin C Amyloidosis 66
Hchwa, Icelandic Type 56
Cystatin Amyloidosis 56
Acys Amyloidosis 56
Amyloidosis Vi 24
Caa, Familial 50
Amyloidosis 6 66
Hchwa-I 66
Hchwai 66
Hccaa 66
Amyl6 66
Acys 66
Caa 66

Characteristics:

Orphanet epidemiological data:

56
hereditary cerebral hemorrhage with amyloidosis
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: adult;
acys amyloidosis
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Adolescent,Adult; Age of death: adult;

HPO:

32
cerebral amyloid angiopathy:
Mortality/Aging death in early adulthood
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 105150
Disease Ontology 12 DOID:9246
MeSH 42 D028243
SNOMED-CT 64 56453003
ICD10 via Orphanet 34 E85.4+ I68.0*
ICD10 33 I68.0
UMLS 69 C0268394

Summaries for Cerebral Amyloid Angiopathy

NIH Rare Diseases : 50 hereditary cerebral hemorrhage with amyloidosis (hchwa) is a neurological condition in which an abnormal protein (amyloid) builds up in the walls of the arteries of the brain (and less frequently, veins). this process is known as amyloid deposition, which can lead to strokes, seizures, neurological deficits, cognitive decline, and dementia. symptoms usually present before the 5th decade of life. there are many different ways of classifying the types of hchwa based on the underlying genetic changes, proteins involved, signs and symptoms, and the regions in which they were first described. based on the region in which they were first described, the subtypes include:the dutch, arctic, piedmont, iowa, flemish, italian types are caused by mutations in the app gene the british and danish types are caused by mutations in the itm2b gene the icelandic type is caused by mutations in the cst3 gene  all types of hchwa currently described are inherited in an autosomal dominant manner. there is no cure for hchwa, however, antihypertensive therapy is typically recommended. last updated: 7/19/2016

MalaCards based summary : Cerebral Amyloid Angiopathy, also known as hereditary cerebral hemorrhage with amyloidosis, is related to cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants and hereditary cerebral amyloid angiopathy, and has symptoms including stroke, cerebral hemorrhage and death in early adulthood. An important gene associated with Cerebral Amyloid Angiopathy is CST3 (Cystatin C), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. Affiliated tissues include brain, cortex and spleen, and related phenotypes are homeostasis/metabolism and integument

UniProtKB/Swiss-Prot : 66 Amyloidosis 6: A hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.

OMIM : 54 Cerebral amyloid angiopathy (CAA), defined by the deposition of congophilic material in the vessels of the cortex and... (105150) more...

Disease Ontology : 12 An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia.

Wikipedia : 71 Cerebral amyloid angiopathy (CAA), also known as congophilic angiopathy, is a form of angiopathy in... more...

Related Diseases for Cerebral Amyloid Angiopathy

Diseases in the Cerebral Amyloid Angiopathy family:

Hereditary Cerebral Amyloid Angiopathy

Diseases related to Cerebral Amyloid Angiopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
id Related Disease Score Top Affiliating Genes
1 cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants 12.6
2 hereditary cerebral amyloid angiopathy 12.6
3 dementia, familial british 12.0
4 dementia, familial danish 12.0
5 alzheimer disease 11.9
6 aural atresia, congenital 11.7
7 cerebritis 11.2
8 hereditary amyloidosis 11.2
9 gerstmann-straussler disease 11.1
10 dementia 10.6
11 siderosis 10.5
12 superficial siderosis 10.5
13 cerebral hemorrhage 10.4
14 postaxial polydactyly, type a2 10.3 CST3 ITM2B
15 rieger syndrome, type 2 10.3 APP ITM2B
16 ectodermal dysplasia mental retardation syndactyly 10.3 APP PSEN1
17 encephalopathy 10.2
18 urethritis 10.2 APOE PSEN1
19 amyloidosis 10.2
20 active cochlear meniere's disease 10.2 APP MME
21 pick disease 10.2 APP PSEN1
22 mitochondrial dna depletion syndrome 14, cardioencephalomyopathic type 10.2 APP ITM2B
23 homocystinuria caused by cystathionine beta-synthase deficiency 10.2 APOE PRNP
24 porencephaly 2 10.2 APOE APP CST3
25 fancf-related fanconi anemia 10.2 APOE PRNP
26 encephalitozoonosis 10.2 APOE APP PSEN1
27 intracranial structure hemangioma 10.2 APP PSEN1
28 foxp2-related speech and language disorders 10.2 APP ITM2B PSEN1
29 severe congenital nemaline myopathy 10.1 APOE PSEN1
30 vascular dementia 10.1
31 primary angiitis of the central nervous system 10.1
32 acromegaly 10.1 MME SERPINA3
33 myopathy, myofibrillar, fatal infantile hypertrophy, alpha-b crystallin-related 10.1 APP GSN
34 anaplastic ependymoma 10.1 GSN TTR
35 cellulitis 10.1 GSN TTR
36 charcot-marie-tooth disease 10.1 APP CST3 PRNP
37 neuronitis 10.1
38 polyneuropathy 10.1
39 brain injury 10.1
40 traumatic brain injury 10.1
41 syringocystadenoma papilliferum 10.1 APOE APP PRNP
42 cardiomyopathy, dilated, 1v 10.1 APP PSEN1
43 hereditary lymphedema type ii 10.1 GSN TTR
44 prion disease with protracted course 10.1 APOE CST3 PRNP
45 penis agenesis 10.1 GSN TTR
46 autoimmune disease of urogenital tract 10.1 APOE PRNP PSEN1
47 huntington disease-like 1 10.1 APP PRNP
48 alopecia-mental retardation syndrome 3 10.1 GSN TTR
49 arthrogryposis, lethal, with anterior horn cell disease 10.0 APOE GSN TTR
50 endotheliitis 10.0

Graphical network of the top 20 diseases related to Cerebral Amyloid Angiopathy:



Diseases related to Cerebral Amyloid Angiopathy

Symptoms & Phenotypes for Cerebral Amyloid Angiopathy

Symptoms by clinical synopsis from OMIM:

105150

Clinical features from OMIM:

105150

Human phenotypes related to Cerebral Amyloid Angiopathy:

56 32 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 stroke 56 32 Very frequent (99-80%) HP:0001297
2 cerebral hemorrhage 56 32 Very frequent (99-80%) HP:0001342
3 cerebral amyloid angiopathy 56 32 Very frequent (99-80%) HP:0011970
4 death in early adulthood 56 Occasional (29-5%)
5 dementia 32 HP:0000726
6 intracranial hemorrhage 32 HP:0002170
7 amyloidosis 56 Frequent (79-30%)
8 generalized amyloid deposition 32 HP:0003216

MGI Mouse Phenotypes related to Cerebral Amyloid Angiopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 APOE APP BACE1 CST3 GSN LRP1
2 integument MP:0010771 9.87 APOE APP BACE1 GSN MME PRNP
3 nervous system MP:0003631 9.81 APP BACE1 CST3 GSN ITM2B LRP1
4 muscle MP:0005369 9.8 APOE APP BACE1 CST3 LRP1 PRNP
5 no phenotypic analysis MP:0003012 9.43 PRNP TTR APOE APP BACE1 ITM2B
6 reproductive system MP:0005389 9.17 APOE APP CST3 GSN LRP1 PRNP

Drugs & Therapeutics for Cerebral Amyloid Angiopathy

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study of CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease Not yet recruiting NCT03131453 Phase 2, Phase 3
2 Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy Completed NCT01821118 Phase 2
3 Cerebril™ in Patients With Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy Completed NCT00056238 Phase 2
4 Methods of Etiological Diagnosis of Cerebral Amyloid Angiopathy Unknown status NCT02361411
5 The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage? Completed NCT02837354
6 Amyloid Imaging and Cognitive Impairment After Intracerebral Hemorrhage Recruiting NCT01619709
7 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
8 Genetics of Mendelian Forms of Young Onset Alzheimer Disease Active, not recruiting NCT01622894
9 Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis Not yet recruiting NCT02664571
10 F-18-AV-45 Uptake, Spot Sign Presence and Cerebral Amyloid Angiopathy (CAA) in Primary Intracranial Hemorrhage (ICH) Withdrawn NCT01382849

Search NIH Clinical Center for Cerebral Amyloid Angiopathy

Cochrane evidence based reviews: cerebral amyloid angiopathy, familial

Genetic Tests for Cerebral Amyloid Angiopathy

Genetic tests related to Cerebral Amyloid Angiopathy:

id Genetic test Affiliating Genes
1 Cerebral Amyloid Angiopathy 29
2 Cst3-Related Cerebral Amyloid Angiopathy 24 CST3

Anatomical Context for Cerebral Amyloid Angiopathy

MalaCards organs/tissues related to Cerebral Amyloid Angiopathy:

39
Brain, Cortex, Spleen, Salivary Gland, Smooth Muscle, Bone, Endothelial

Publications for Cerebral Amyloid Angiopathy

Articles related to Cerebral Amyloid Angiopathy:

(show top 50) (show all 649)
id Title Authors Year
1
Tumoral Presentation of Homonymous Hemianopia and Prosopagnosia in Cerebral Amyloid Angiopathy-Related Inflammation. ( 28187081 )
2017
2
Relationship between white matter connectivity loss and cortical thinning in cerebral amyloid angiopathy. ( 28462514 )
2017
3
Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. ( 28356458 )
2017
4
Visuospatial Functioning in Cerebral Amyloid Angiopathy: A Pilot Study. ( 28222510 )
2017
5
Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature. ( 27812816 )
2017
6
Erratum to: Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. ( 28243752 )
2017
7
Taxifolin inhibits amyloid-I^ oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. ( 28376923 )
2017
8
Histological and immunohistochemical characteristics of cerebral amyloid angiopathy in elderly dogs. ( 27669976 )
2017
9
Identification of neurovascular changes associated with cerebral amyloid angiopathy from subject-specific hemodynamic response functions. ( 28145796 )
2017
10
Cerebral amyloid angiopathy: a long-term consequence of traumatic brain injury? ( 27796651 )
2017
11
Emerging concepts in sporadic cerebral amyloid angiopathy. ( 28334869 )
2017
12
Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. ( 28154972 )
2017
13
Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease. ( 28463681 )
2017
14
Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy. ( 28478503 )
2017
15
Erratum to: Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature. ( 27913939 )
2017
16
APP Mutations in Cerebral Amyloid Angiopathy with or without Cortical Calcifications: Report of Three Families and aA Literature Review. ( 27858710 )
2017
17
Intracranial IL-17A overexpression decreases cerebral amyloid angiopathy by upregulation of ABCA1 in an animal model of Alzheimer's disease. ( 28526436 )
2017
18
I^-Amyloid in CSF: Biomarker for preclinical cerebral amyloid angiopathy. ( 27903811 )
2017
19
18F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy. ( 28282808 )
2017
20
Distribution of lacunes in cerebral amyloid angiopathy and hypertensive small vessel disease. ( 28476760 )
2017
21
Creutzfeldt-Jakob disease, cerebral amyloid angiopathy and AI^-related angiitis with neuropsychiatric manifestations. ( 28176535 )
2017
22
Dementia incidence and predictors in cerebral amyloid angiopathy patients without intracerebral hemorrhage. ( 28318355 )
2017
23
Imaging the Acute Formation of a Cortical Microbleed in Cerebral Amyloid Angiopathy. ( 27893876 )
2017
24
MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy. ( 28228568 )
2017
25
Cerebrovascular function in presymptomatic and symptomatic individuals with hereditary cerebral amyloid angiopathy: a case-control study. ( 27989553 )
2017
26
Cerebral Amyloid Angiopathy-Related Microbleeds and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease. ( 27802236 )
2017
27
Amyloid-Related Imaging Abnormalities inA an Aged Squirrel Monkey with Cerebral Amyloid Angiopathy. ( 28269776 )
2017
28
Cerebral Amyloid Angiopathy in Stroke Medicine. ( 28179050 )
2017
29
Lacunes: Black holes in our understanding of cerebral amyloid angiopathy. ( 28476757 )
2017
30
Acute Convexity Subarachnoid Hemorrhage Related to Cerebral Amyloid Angiopathy: Clinicoradiological Features and Outcome. ( 26923093 )
2016
31
Sporadic Cerebral Amyloid Angiopathy: Pathophysiology, Neuroimaging Features, and Clinical Implications. ( 27214698 )
2016
32
Vicinity of FLAIR Hyperintensities and SWI Microbleeds in Cerebral Amyloid Angiopathy-Related Inflammation. ( 27115699 )
2016
33
Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer's Disease. ( 27915995 )
2016
34
Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy. ( 26988843 )
2016
35
Influence of Low-dose Aspirin on Cerebral Amyloid Angiopathy in Mice. ( 27079719 )
2016
36
Progression of Brain Network Alterations in Cerebral Amyloid Angiopathy. ( 27576378 )
2016
37
Microbleeds on MRI are associated with microinfarcts on autopsy in cerebral amyloid angiopathy. ( 27613583 )
2016
38
Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy. ( 27771772 )
2016
39
Clinico-Radiological Characteristics and Pathological Diagnosis of Cerebral Amyloid Angiopathy-Related Intracerebral Hemorrhage. ( 27151414 )
2016
40
Intracerebral hemorrhage due to cerebral amyloid angiopathy after head injury: Report of a case and review of the literature. ( 27145894 )
2016
41
Pre-critical MRI findings of an Alzheimer's disease patient with pathologically proven cerebral amyloid angiopathy related lobar hemorrhage. ( 27151228 )
2016
42
Sporadic cerebral amyloid angiopathy as a cause of relapsing lobar hemorrhage, convexal subarachnoid hemorrhage and cortical superficial siderosis. ( 27259571 )
2016
43
Cognitive Profile and its Association with Neuroimaging Markers of Non-Demented Cerebral Amyloid Angiopathy Patients in a Stroke Unit. ( 27060947 )
2016
44
Iowa APP mutation-related hereditary cerebral amyloid angiopathy (CAA): A new family from Spain. ( 27000221 )
2016
45
High-Fat-Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders. ( 27412896 )
2016
46
Florbetapir-PET to diagnose cerebral amyloid angiopathy: A prospective study. ( 27605173 )
2016
47
Systems proteomic analysis reveals that Clusterin and Tissue Inhibitor of Metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy. ( 27543695 )
2016
48
Intracerebral haemorrhage recurrence in cerebral amyloid angiopathy: Time to look beyond microbleeds? ( 27423589 )
2016
49
Evolution of Subarachnoid Hemorrhage Extension in Lobar Hemorrhage in the Early Chronic Phase and the Impact on Cerebral Amyloid Angiopathy Criteria. ( 27542696 )
2016
50
Cerebral Arterial Occlusion Did Not Promote the Prevalence of Cerebral Amyloid Angiopathy. ( 27497483 )
2016

Variations for Cerebral Amyloid Angiopathy

UniProtKB/Swiss-Prot genetic disease variations for Cerebral Amyloid Angiopathy:

66
id Symbol AA change Variation ID SNP ID
1 CST3 p.Leu94Gln VAR_002207 rs28939068

ClinVar genetic disease variations for Cerebral Amyloid Angiopathy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CST3 NM_000099.3(CST3): c.281T> A (p.Leu94Gln) single nucleotide variant Pathogenic rs28939068 GRCh37 Chromosome 20, 23615967: 23615967

Expression for Cerebral Amyloid Angiopathy

Search GEO for disease gene expression data for Cerebral Amyloid Angiopathy.

Pathways for Cerebral Amyloid Angiopathy

GO Terms for Cerebral Amyloid Angiopathy

Cellular components related to Cerebral Amyloid Angiopathy according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 APOE APP CST3 GSN HSPB6 ITM2B
2 Golgi apparatus GO:0005794 9.93 APOE APP BACE1 ITM2B PRNP PSEN1
3 cell surface GO:0009986 9.84 APP BACE1 PRNP PSEN1
4 extracellular exosome GO:0070062 9.81 APOE APP CST3 GSN ITM2B MME
5 extracellular space GO:0005615 9.8 APOE APP CST3 GSN ITM2B SERPINA3
6 neuronal cell body GO:0043025 9.78 APOE CST3 LRP1 PSEN1
7 endoplasmic reticulum lumen GO:0005788 9.73 APOE APP BACE1 CST3
8 blood microparticle GO:0072562 9.7 APOE GSN SERPINA3
9 membrane raft GO:0045121 9.62 APP BACE1 PRNP PSEN1
10 dendritic shaft GO:0043198 9.55 APP PSEN1
11 smooth endoplasmic reticulum GO:0005790 9.51 APP PSEN1
12 multivesicular body GO:0005771 9.49 BACE1 CST3
13 ciliary rootlet GO:0035253 9.4 APP PSEN1
14 dendrite GO:0030425 9.35 APOE LRP1 MME PRNP PSEN1
15 axon GO:0030424 9.02 APP BACE1 CST3 MME PSEN1

Biological processes related to Cerebral Amyloid Angiopathy according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.85 CST3 GSN MME PSEN1 SERPINA3 TTR
2 negative regulation of endopeptidase activity GO:0010951 9.75 APP CST3 SERPINA3
3 negative regulation of neuron apoptotic process GO:0043524 9.74 APOE LRP1 PSEN1
4 negative regulation of peptidase activity GO:0010466 9.73 APP CST3 SERPINA3
5 retinoid metabolic process GO:0001523 9.67 APOE LRP1 TTR
6 learning or memory GO:0007611 9.65 APP PRNP PSEN1
7 response to oxidative stress GO:0006979 9.65 APOE APP CST3 PRNP PSEN1
8 regulation of synaptic plasticity GO:0048167 9.61 APP PSEN1
9 positive regulation of dendritic spine development GO:0060999 9.6 APOE PSEN1
10 membrane protein ectodomain proteolysis GO:0006509 9.59 BACE1 PSEN1
11 regulation of protein binding GO:0043393 9.58 APP PSEN1
12 positive regulation of cholesterol efflux GO:0010875 9.55 APOE LRP1
13 cellular copper ion homeostasis GO:0006878 9.54 APP PRNP
14 amyloid precursor protein metabolic process GO:0042982 9.52 APOE PSEN1
15 amyloid fibril formation GO:1990000 9.51 APP GSN
16 beta-amyloid metabolic process GO:0050435 9.5 BACE1 MME PSEN1
17 regulation of epidermal growth factor-activated receptor activity GO:0007176 9.46 APP PSEN1
18 negative regulation of long-term synaptic potentiation GO:1900272 9.43 APOE PRNP
19 smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 9.4 APP PSEN1
20 cellular response to beta-amyloid GO:1904646 9.33 APP LRP1 PSEN1
21 cellular protein metabolic process GO:0044267 9.23 APOE APP BACE1 CST3 GSN ITM2B
22 astrocyte activation involved in immune response GO:0002265 9.13 APP LRP1 PSEN1

Molecular functions related to Cerebral Amyloid Angiopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 APOE APP BACE1 CST3 GSN HSPB6
2 identical protein binding GO:0042802 9.72 APOE APP CST3 PRNP TTR
3 peptidase inhibitor activity GO:0030414 9.43 APP CST3 SERPINA3
4 aspartic-type endopeptidase activity GO:0004190 9.37 BACE1 PSEN1
5 endopeptidase activity GO:0004175 9.33 BACE1 MME PSEN1
6 beta-amyloid binding GO:0001540 9.02 APOE BACE1 CST3 ITM2B PRNP

Sources for Cerebral Amyloid Angiopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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