Cerebral Amyloid Angiopathy malady

Genetics Home Reference: Hereditary cerebral amyloid angiopathy is a condition that can cause a progressive loss of intellectual function (dementia), stroke, and other neurological problems starting in mid-adulthood. Due to neurological decline, this condition is typically fatal in one's sixties, although there is variation depending on the severity of the signs and symptoms. Most affected individuals die within a decade after signs and symptoms first appear, although some people with the disease have survived longer.¹⁷

MalaCards: Cerebral Amyloid Angiopathy, also known as hereditary cerebral haemorrhage with amyloidosis - dutch type (disorder), is related to hereditary cerebral amyloid angiopathy and alzheimer's disease. An important gene associated with Cerebral Amyloid Angiopathy is APP (amyloid beta (A4) precursor protein), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Cytoskeleton remodeling Slit-Robo signaling. The compounds threonine and glucose have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and smooth muscle, and related mouse phenotypes are hematopoietic system and respiratory system.

Wikipedia: For a comprehensive review and update, see ⁴⁴ more...

OMIM: 105150

Aliases & Descriptions:

cerebral amyloid angiopathy 6 7 8 33 32 43 hereditary cerebral haemorrhage with amyloidosis - dutch type (disorder) 6 dutch hereditary cerebral amyloid angiopathy 6

cerebral amyloid angiopathy, hereditary 43 cerebral hemorrhage 43

Diseases related to cerebral amyloid angiopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 433)

id	Related Disease	Score	Top Affiliating Genes
1	hereditary cerebral amyloid angiopathy	37.4	TUBB, CST3
2	alzheimer's disease	36.8	LRP1, APOE, APP, A2M, ACE
3	dementia familial british	31.8	ITM2B, APP, TUBB
4	hereditary cerebral hemorrhage with amyloidosis	31.7	IL6, APP, HSPB6, HSPB8, RPS27A, PSEN1
5	arteriosclerosis	30.9	IL6, APOE, APP, PLAT, ACE, TTR
6	cerebral hemorrhage	30.8	SERPINA3, IL6, APOE, APP, HSPB6, HSPB8
7	vascular dementia	29.7	SERPINA3, BCHE, APOE, APP, MBP, MAPT
8	polyneuropathy	29.1	MMP9, GSN, IL6, APOE, APP, MBP
9	anorexia nervosa	27.3	MME, IL6, APOE, PLAT, ABCB1, TTR
10	traumatic brain injury	26.7	MME, MMP9, IL1A, IL6, AQP4, APOE
11	brain injury	26.2	MME, MMP9, IL1A, IL6, AQP4, APOE
12	cerebritis	26.1	LRP1, SERPINA3, BCHE, CH25H, ITM2B, MME
13	amyloidosis	25.7	LRP1, SERPINA3, ITM2B, MME, MMP9, GSN
14	dementia	25.2	LRP1, SERPINA3, BCHE, ITM2B, MME, MMP9
15	cerebral infarction	24.3	MMP9, IL1A, IL6, AQP4, APOE, AOC3
16	hyperglycemia	23.9	MMP9, IL1A, IL6, AOC3, IDE, CAV1
17	atherosclerosis	22.9	LRP1, MME, MMP9, IL1A, IL6, APOE
18	hypertension	22.0	LRP1, SERPINA3, MME, MMP9, IL1A, IL6
19	neuronitis	19.3	LRP1, SERPINA3, BCHE, ITM2B, MME, MMP9
20	cholesterol	18.8	LRP1, SERPINA3, BCHE, CH25H, MMP9, IL1A
21	binswanger's disease	13.8	APOE, APP, MAPT
22	cognitive disease	13.7	APOE, APP, MAPT
23	pick's disease	13.7	MAPT, PSEN1
24	al amyloidosis	13.7	APP, TTR, CST3
25	niemann-pick disease type c1	13.7	APP, MAPT, ABCA1
26	lattice corneal dystrophy type ii	13.7	GSN, APOE, TTR
27	scrapie	13.6	APOE, APP, MAPT, PRNP, CST3
28	gerstmann-straussler-scheinker disease	13.6	APP, PRNP
29	alzheimer disease type 3	13.6	MAPT, PSEN1, PSEN2
30	early-onset familial alzheimer disease	13.6	APP, PSEN1, PSEN2, CST3
31	semantic dementia	13.6	APOE, MAPT, RPS27A
32	familial idiopathic basal ganglia calcification	13.6	APP, MAPT, PSEN1, PSEN2
33	basal ganglia calcification	13.5	APP, MAPT, PSEN1, PSEN2
34	distal hereditary motor neuropathy, type ii	13.5	HSPB8, TUBA1B, TUBB
35	bovine spongiform encephalopathy	13.5	AQP1, AQP4, PRNP
36	inclusion body myositis	13.5	MME, APP, MAPT, RPS27A
37	inclusion body myopathy	13.5	MME, APP, RPS27A, PSEN1
38	hereditary amyloidosis	13.5	GSN, TTR
39	amyloid neuropathy	13.5	GSN, TTR
40	alzheimer disease type 2	13.5	BCHE, IDE
41	tauopathy	13.5	APP, MAPT, RPS27A, PSEN1
42	cerebral atrophy	13.5	APOE, MAPT, RPS27A
43	neuroaxonal dystrophy, infantile	13.4	APP, RPS27A
44	alzheimer disease type 1	13.4	APOE, APP, MAPT, PSEN1, PSEN2, CST3
45	corticobasal degeneration	13.4	MAPT, HSPB2, RPS27A
46	prion disease	13.4	APP, MAPT, PSEN1, PSEN2, PRNP, CST3
47	central nervous system disease	13.4	APP, MBP, MAPT, TTR
48	niemann–pick disease	13.4	APP, MBP, MAPT, ABCA1
49	primary progressive aphasia	13.4	MAPT, RPS27A
50	memory impairment	13.3	BCHE, APOE, APP, MAPT, PSEN1, PRNP

Clinical features from OMIM: 105150

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cerebral amyloid angiopathy:

²²

MGI Mouse Phenotypes related to cerebral amyloid angiopathy:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.3	IFNAR1, AQP1, GSN
2	respiratory system phenotype	MP:0005388	9.8	PSEN2, PSEN1, ABCA1, HSPB8, APOE, AQP4
3	no phenotypic analysis	MP:0003012	9.5	ABCG2, IFNAR1, MAPT, APP, AQP4, ITM2B
4	endocrine/exocrine gland phenotype	MP:0005379	9.5	PSEN2, PSEN1, CAV1, AQP1, GSN
5	liver/biliary system phenotype	MP:0005370	9.3	ABCB1, ABCA1, IL6
6	renal/urinary system phenotype	MP:0005367	9.2	PSEN2, PSEN1, ABCA1, CAV1, IFNAR1, MAPT
7	integument phenotype	MP:0010771	9.0	PSEN2, PSEN1, ABCG2, CAV1, IFNAR1, MAPT
8	other phenotype	MP:0005395	8.6	ABCA1, ABCB1, ABCG2, PSEN1, PRNP, CAV1
9	reproductive system phenotype	MP:0005389	8.2	PRNP, TGFB1, CAV1, IFNAR1, APP, IL6
10	nervous system phenotype	MP:0003631	8.0	CST3, PSEN1, TGFB1, ABCG2, CAV1, HSPB2
11	immune system phenotype	MP:0005387	7.8	OLR1, PLAT, ABCA1, PSEN1, PSEN2, PRNP
12	adipose tissue phenotype	MP:0005375	7.6	TGFB1, ACE, CAV1, CAV2, HSPB2, APOE
13	digestive/alimentary phenotype	MP:0005381	7.3	PSEN2, PSEN1, TGFB1, ABCA1, PLAT, CAV1
14	growth/size phenotype	MP:0005378	7.3	PLAT, ABCA1, ACE, PSEN1, PSEN2, PRNP
15	vision/eye phenotype	MP:0005391	7.0	HSPB2, PLAT, TTR, TGFB1, PSEN1, PSEN2
16	muscle phenotype	MP:0005369	6.9	OLR1, PLAT, ABCA1, TGFB1, PSEN1, PRNP
17	tumorigenesis	MP:0002006	6.8	CST3, TGFB1, ACE, CAV1, IFNAR1, MAPT
18	behavior/neurological phenotype	MP:0005386	5.2	CAV1, PLAT, ABCB1, ACE, TGFB1, PSEN1
19	cellular phenotype	MP:0005384	5.0	PLAT, ABCA1, ABCB1, ACE, TGFB1, PSEN1
20	homeostasis/metabolism phenotype	MP:0005376	4.8	LRP1, OLR1, PLAT, ABCA1, ABCB1, ABCG2
21	cardiovascular system phenotype	MP:0005385	4.7	PLAT, ABCA1, ABCB1, ABRA, ACE, TGFB1
22	mortality/aging	MP:0010768	4.4	HSPB2, CAV1, PLAT, ABCA1, ABCB1, ACE

Articles related to cerebral amyloid angiopathy:

(show top 50)    (show all 105)

id	Title	Authors	Year	Affiliating Genes
1	Capillary cerebral amyloid angiopathy identifies a di stinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. (20535486)	Thal D.R.... Ghebremedhin E.	2010	LRP1, APOE, CH25H
2	ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides. (19403814)	Xiong H.... Zhang W.	2009	ABCG2
3	Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2. (18410407)	Vidal R.... Ghetti B.	2009	ITM2B
4	Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion. (17629591)	Wilhelmus M.M.... Verbeek M.M.	2009	IL6, HSPB8, HSPB6
5	Cerebral amyloid angiopathy: a common cause of cerebr al hemorrhage. (19601795)	Pezzini A.... Padovani A.	2009	APP, GSN, TTR
6	Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques. (18184371)	Kumar-Singh S.	2008	APP
7	The contribution of cerebral vascular semicarbazide-sensitive amine oxidase to cerebral amyloid angiopathy in Alzheimer's disease. (17971074)	Jiang Z.J.... Yu P.H.	2008	AOC3
8	Human postmortem brain-derived cerebrovascular smooth muscle cells express all genes of the classical complement pathway: a potential mechanism for vascular damage in cerebral amyloid angiopathy and Alzheimer's disease. (18048067)	Walker D.G.... Lue L.F.	2008	C1R
9	Cerebral amyloid angiopathy and its relationship to Alzheimer's disease. (18369648)	Thal D.R.... Ghebremedhin E.	2008	APP
10	Caveolin-1 and -2 and their relationship to cerebral amyloid angiopathy in Alzheimer's disease. (17493012)	van Helmond Z.K.... Kehoe P.G.	2007	CAV1, CAV2
11	Inhibition of familial cerebral amyloid angiopathy mutant amyloid beta-protein fibril assembly by myelin basic protein. (17259179)	Hoos M.D.... Van Nostrand W.E.	2007	APP, MBP
12	Differential deposition of amyloid beta peptides in cerebral amyloid angiopathy associated with Alzheimer's disease and vascular dementia. (16555084)	Haglund M.... Englund E.	2006	APP
13	Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy. (17021406)	Miners J.S.... Kehoe P.G.	2006	MME
14	Association of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy. (15834029)	Hamaguchi T.... Yamada M.	2005	TGFB1, APOE
15	Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotype. (15654038)	Leclercq P.D.... Gentleman S.M.	2005	APOE
16	Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage. (15760647)	Lee J.M.... Xu J.	2005	MMP9
17	Clinical manifestations of cerebral amyloid angiopathy-related inflammation. (14755729)	Eng J.A.... Greenberg S.M.	2004	APP
18	Cerebral amyloid angiopathy and dementia. (15876981)	Tian J.... Mann D.M.	2004	APP, GSN, TTR
19	Cerebral amyloid angiopathy and gene polymorphisms. (15537517)	Yamada M.	2004	PSEN1, SERPINA3
20	Hereditary dementia with intracerebral hemorrhages and cerebral amyloid angiopathy. (15277614)	Remes A.M.... Majamaa K.	2004	APP, PSEN2, PSEN1
21	Negative association between amyloid plaques and cerebral amyloid angiopathy in Alzheimer's disease. (14625042)	Tian J.... Mann D.M.	2003	APP
22	Association of neprilysin polymorphism with cerebral amyloid angiopathy. (12754344)	Yamada M.... Mizusawa H.	2003	APP, MME
23	Cerebral amyloid angiopathy in aged Chinese: a clinico-neuropathological study. (12698265)	Xu D.... Wang L.	2003	APP
24	Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease. (12944403)	Murakami K.... Shirasawa T.	2003	APP
25	Declining expression of neprilysin in Alzheimer disease vasculature: possible involvement in cerebral amyloid angiopathy. (12387451)	Carpentier M.... Marcinkiewicz M.	2002	MME
26	Cerebral amyloid angiopathy and vessel dysfunction. (11901242)	Greenberg S.M.	2002	APP
27	Cerebral amyloid angiopathy associated with hemorrhage: immunohistochemical study of 41 biopsy cases. (11760381)	Izumihara A.... Ito H.	2001	APP, APOE, CST3
28	Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy. (11816788)	Holtzman D.M.	2001	APOE
29	Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy. (10644793)	Yasuda M.... Tanaka C.	2000	PSEN1
30	Cerebral amyloid angiopathy: an overview. (10935432)	Yamada M.	2000	ITM2B
31	Increased frequency of the alpha-1-antichymotrypsin T allele in cerebral amyloid angiopathy. (11132933)	Durany N.... Cruz-Sanchez F.F.	2000	SERPINA3
32	Cerebral amyloid angiopathies (11094619)	Masson C.... BuAce L.	2000	CST3
33	Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons. (11021833)	Van Dorpe J.... Van Leuven F.	2000	APP
34	Association of alpha1-antichymotrypsin polymorphism with cerebral amyloid angiopathy. (9667601)	Yamada M.... Mizusawa H.	1998	SERPINA3
35	Butyrylcholinesterase K variant and cerebral amyloid angiopathy. (9836756)	Yamada M.... Mizusawa H.	1998	BCHE
36	No mutations in cystatin C gene in cerebral amyloid angiopathy with cystatin C deposition. (9493177)	Nagai A.... Nakamura M.	1998	CST3
37	Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy. (9274858)	Urmoneit B.... Prior R.	1997	APOE
38	Cerebral amyloid angiopathy and apolipoprotein E: bad news for the good allele? (9189029)	Greenberg S.M.... Hyman B.T.	1997	APOE
39	Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype. (9153536)	Bornebroek M.... Roos R.A.	1997	APOE
40	Immune reactions associated with cerebral amyloid angiopathy. (8685920)	Yamada M.... Otomo E.	1996	CST3
41	Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. (8711797)	Greenberg S.M.... Pessin M.S.	1996	APOE
42	Leukoencephalopathy-related cerebral amyloid angiopathy with cystatin C deposition. (8711812)	Shimode K.... Nagai A.	1996	CST3
43	Apolipoprotein E genotype and cerebral amyloid angiopathy. (7475834)	Kalaria R.N.... Premkumar D.R.	1995	APOE
44	beta-Amyloid precursor protein gene in squirrel monkeys with cerebral amyloid angiopathy. (8532114)	Levy E.... Walker L.C.	1995	APP
45	Clinical aspects of cerebral amyloid angiopathy. (8087182)	Haan J.... Roos R.A.	1994	TTR, CST3
46	Creutzfeldt-Jakob disease and cerebral amyloid angiopathy. (7941967)	Gray F.... Degos J.D.	1994	PRNP
47	Spinal cord vascular and leptomeningeal amyloid beta- protein deposition in a case with cerebral amyloid angiopathy. (1523975)	Tokuda T.... Ito N.	1992	APP
48	Characterization of amyloid fibril protein from a case of cerebral amyloid angiopathy showing immunohistochemical reactivity for both beta protein and cystatin C. (1436711)	Maruyama K.... Yanagisawa N.	1992	CST3
49	Transthyretin-type cerebral amyloid angiopathy in type I familial amyloid polyneuropathy. (1858483)	Ushiyama M.... Yanagisawa N.	1991	TTR
50	Diagnosis of cerebral amyloid angiopathy by enzyme-linked immunosorbent assay of cystatin C in cerebrospinal fluid. (1853405)	Shimode K.... Tsunematsu T.	1991	CST3

Genes related to cerebral amyloid angiopathy according to GeneCards:

(show all 48)

id	Symbol	Description	Score	GeneCards Section Context
1	APP	amyloid beta (A4) precursor protein	11.1	Publications, Summaries
2	CST3	cystatin C	11.1	Publications
3	APOE	apolipoprotein E	11.1	Publications
4	ITM2B	integral membrane protein 2B	11.0	Publications
5	HSPB6	heat shock protein, alpha-crystallin-related, B6	11.0	Publications
6	AOC3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	11.0	Publications
7	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
8	IFNAR1	interferon (alpha, beta and omega) receptor 1	11.0	Publications
9	LRP1	low density lipoprotein receptor-related protein 1	11.0	Publications
10	TTR	transthyretin	11.0	Publications
11	TUBB	tubulin, beta class I	11.0	Publications
12	MME	membrane metallo-endopeptidase	11.0	Publications
13	PSEN1	presenilin 1	11.0	Publications
14	PRNP	prion protein	11.0	Publications
15	PON1	paraoxonase 1	11.0	Publications
16	MAPT	microtubule-associated protein tau	11.0
17	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	11.0
18	CH25H	cholesterol 25-hydroxylase	11.0	Publications
19	TUBB4A	tubulin, beta 4A class IVa	11.0	Publications
20	C1R	complement component 1, r subcomponent	11.0	Publications
21	ABRA	actin-binding Rho activating protein	11.0	Disorders
22	HSPB8	heat shock 22kDa protein 8	11.0	Publications
23	AQP4	aquaporin 4	11.0	Publications
24	C1D	C1D nuclear receptor corepressor	11.0
25	CAV2	caveolin 2	11.0	Publications
26	CYP46A1	cytochrome P450, family 46, subfamily A, polypeptide 1	11.0	Publications
27	GSN	gelsolin	11.0	Publications
28	ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	11.0
29	HSPB2	heat shock 27kDa protein 2	11.0
30	OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	11.0	Publications
31	IDE	insulin-degrading enzyme	11.0	Publications
32	AQP1	aquaporin 1 (Colton blood group)	11.0	Publications
33	A2M	alpha-2-macroglobulin	11.0	Publications
34	PSEN2	presenilin 2 (Alzheimer disease 4)	11.0	Publications
35	TUBA1B	tubulin, alpha 1b	11.0	Publications
36	COLEC12	collectin sub-family member 12	11.0	Expressions
37	RPS27A	ribosomal protein S27a	11.0	Publications
38	BCHE	butyrylcholinesterase	11.0	Publications
39	IL1A	interleukin 1, alpha	11.0	Publications
40	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	11.0	Publications
41	CAV1	caveolin 1, caveolae protein, 22kDa	11.0	Publications
42	PLAT	plasminogen activator, tissue	11.0	Publications
43	MBP	myelin basic protein	11.0	Publications
44	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
45	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
46	TGFB1	transforming growth factor, beta 1	11.0	Publications
47	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
48	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to cerebral amyloid angiopathy according to GeneDecks:

(show all 19)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.5	MME
2	Cytoskeleton remodeling Slit-Robo signaling10	10.1	TUBB4A, TUBB, TUBA1B, MAPT
3	Development_Slit-Robo signaling41	10.1	MAPT, TUBA1B, TUBB, TUBB4A
4	Cell adhesion Gap junctions10	9.9	CAV1, TUBA1B, TUBB, TUBB4A
5	Neuroscience3	9.9	PSEN2, PSEN1, TUBB, TUBA1B, MAPT, APP
6	Cell adhesion_Gap junctions41	9.9	CAV1, TUBA1B, TUBB, TUBB4A
7	Neurophysiological process Receptor-mediated axon growth repulsion10	9.9	MAPT, TUBA1B, TUBB, TUBB4A
8	Neurophysiological process_Receptor-mediated axon growth repulsion41	9.9	MAPT, TUBA1B, TUBB, TUBB4A
9	Alzheimers Disease Pathway36	9.9	LRP1, PSEN2, PSEN1, A2M, MAPT, APP
10	Taxane Pathway, Pharmacokinetics34	9.9	ABCG2, ABCB1, MAPT
11	Alzheimers disease20	9.8	PSEN2, PSEN1, IDE, MAPT, APP, APOE
12	Statin Pathway, Pharmacodynamics34	9.7	ABCB1, APOE, LRP1
13	Phagosome20	9.7	C1R, COLEC12, OLR1, TUBB4A, TUBB, TUBA1B
14	Irinotecan Pathway, Pharmacokinetics34	9.7	ABCG2, ABCB1, BCHE
15	Irinotecan Pathway, Pharmacodynamics34	9.7	ABCG2, ABCB1, BCHE
16	Cytoskeleton remodeling Reverse signaling by ephrin B10	9.6	MAPT, TUBA1B, TUBB, TUBB4A
17	Metalloproteases in connective tissue degradation10	9.6	CST3, MBP, MMP9, LRP1
18	Bile secretion20	9.4	ABCG2, ABCB1, AQP4, AQP1
19	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.1	TGFB1, ACE, MME

Compounds related to cerebral amyloid angiopathy according to GeneDecks:

(show top 50)    (show all 213)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.0	TUBB, MAPT, CAV1, PSEN1, TTR
2	glucose32	9.8	TUBA1B, HSPB2, MME, GSN, AQP1, IDE
3	lysine32	9.7	MME, AOC3, A2M, PSEN2, PRNP, PSEN1
4	pravastatin32 34 9 18 9	13.5	BCHE, IL6, APOE, OLR1, ABCG2
5	methionine32	9.4	CST3, TTR, SERPINA3, MAPT, AQP1, TUBB
6	tacrine32 9 9	11.4	ABCB1, MAPT, APP, APOE, BCHE
7	4-hydroxynonenal32 18	10.3	PON1, PSEN1, TGFB1, RPS27A, MAPT, APP
8	aspartate32	9.2	MMP9, CST3, APP, APOE, MBP, RPS27A
9	lactacystin32	9.1	APOE, ABCA1, PSEN1, PSEN2, RPS27A, MAPT
10	valine32	9.0	MAPT, IDE, TUBA1B, TUBB, RPS27A, TTR
11	leucine32	8.9	AOC3, LRP1, SERPINA3, MME, IDE, TUBA1B
12	folate32	8.9	CAV1, SERPINA3, PON1, CST3, PSEN1, TTR
13	heparin32 9 18 9	11.8	APP, SERPINA3, BCHE, APOE, MBP, MAPT
14	sodium dodecylsulfate32	8.8	LRP1, GSN, IL1A, APOE, APP, MBP
15	glycerol32 9 18 9	11.8	PSEN1, AQP1, AQP4, MAPT, IDE, RPS27A
16	superoxide32 18	9.7	HSPB2, TUBA1B, GSN, CAV1, MME, OLR1
17	oxygen32 18	9.6	SERPINA3, BCHE, CH25H, AOC3, HSPB6, HSPB2
18	h2o232	8.6	PRNP, PSEN2, PSEN1, RPS27A, TUBB, TUBA1B
19	oligonucleotide32	8.5	GSN, LRP1, TUBB, AQP1, AQP4, C1D
20	acetylcholine32 9 18 9	11.4	MME, IL1A, HSPB2, MAPT, APOE, APP
21	calcium32 9 18 9	11.2	AQP1, CST3, PSEN1, ABCG2, C1R, A2M
22	formaldehyde32 18	9.2	MBP, TGFB1, RPS27A, PRNP, TUBB, MAPT
23	atorvastatin32 34 9 18 9	12.1	ABCB1, PON1, PLAT, OLR1, APOE, IL6
24	epinephrine32 9 18 9	11.1	TTR, ABCG2, ABCB1, RPS27A, MMP9, IL1A
25	aspirin32 34 18	9.9	ACE, PON1, TGFB1, PLAT, BCHE, APOE
26	testosterone32 9 18 9	10.8	GSN, MMP9, MME, IL1A, APOE, APP
27	cysteine32	7.7	CST3, PSEN1, RPS27A, PLAT, LRP1, SERPINA3
28	alanine32	7.6	TTR, CST3, PON1, ABCG2, BCHE, MMP9
29	glutamine32	7.6	PSEN1, ABCG2, TTR, TGFB1, CST3, PON1
30	arginine32	7.6	SERPINA3, BCHE, RPS27A, C1D, TTR, PSEN1
31	simvastatin32 34 42 9 18 9	12.5	PON1, ABCB1, MMP9, IL1A, IL6, APOE
32	lactate32	7.3	MBP, MME, PSEN2, TGFB1, TTR, RPS27A
33	paclitaxel32 34 9 9	10.3	PSEN2, ABCG2, ABCB1, TUBB, TUBA1B, CAV1
34	nitric oxide32 9 18 9	10.3	PSEN2, ACE, ABCA1, OLR1, TUBB, CAV1
35	curcumin32	7.3	MMP9, IL1A, IL6, APP, RPS27A, ABCB1
36	glutamate32	7.2	IDE, CAV1, TUBA1B, TUBB, PLAT, RPS27A
37	paraffin32	7.2	MME, SERPINA3, TGFB1, TTR, RPS27A, PLAT
38	actinomycin d32	7.1	RPS27A, APP, APOE, IL6, IL1A, MMP9
39	indomethacin32 9 9	8.8	MME, IL1A, TGFB1, ABCB1, RPS27A, PLAT
40	vegf32	6.8	APP, LRP1, MMP9, MME, CST3, PSEN2
41	cycloheximide32	6.7	PSEN2, PSEN1, TGFB1, CAV1, RPS27A, PLAT
42	creatinine32	6.6	SERPINA3, BCHE, MMP9, IL1A, AQP1, APP
43	estrogen32	6.5	MBP, SERPINA3, MME, TTR, MMP9, APOE
44	tyrosine32	6.3	CAV1, HSPB2, LRP1, MME, MMP9, GSN
45	dexamethasone32 42 34 9 9	10.2	TTR, ABCB1, CST3, TGFB1, AQP1, IL6
46	lipid32	6.2	LRP1, SERPINA3, MME, GSN, IL6, AQP1
47	cyclosporin a32 42	7.1	MME, MMP9, IL1A, ABCG2, TTR, TGFB1
48	cholesterol32 9 18 9	8.9	PLAT, A2M, ABCA1, ABCB1, ABCG2, ACE
49	retinoic acid32 42 18	7.8	SERPINA3, TUBA1B, CAV1, CAV2, PLAT, MAPT
50	serine32	4.4	AQP1, TUBA1B, TUBB, PLAT, RPS27A, A2M

Cellular components related to cerebral amyloid angiopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	internode region of axon	GO:033269	9.9	MBP, TUBB4A
2	integral to plasma membrane	GO:005887	8.5	CAV1, OLR1, ABCA1, PSEN1, PSEN2, CAV2
3	cell surface	GO:009986	7.9	TGFB1, ABCB1, PLAT, CAV1, CAV2, IDE
4	cytosol	GO:005829	7.4	ERCC6L, TUBB, TUBB4A, RPS27A, A2M, PSEN2
5	extracellular region	GO:005576	6.6	PLAT, A2M, C1R, TTR, TGFB1, CST3
6	extracellular space	GO:005615	6.4	ITM2B, PON1, CST3, TGFB1, TTR, ACE
7	plasma membrane	GO:005886	5.6	OLR1, RPS27A, ABCA1, ABCB1, ABCG2, ABRA

Biological processes related to cerebral amyloid angiopathy according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of coagulation	GO:050820	10.4	PSEN1, PSEN2
2	positive regulation of cholesterol efflux	GO:010875	10.4	LRP1, APOE, ABCA1, PON1
3	cholesterol efflux	GO:033344	10.1	APOE, CAV1, ABCA1
4	Notch receptor processing	GO:007220	10.1	PSEN2, PSEN1, RPS27A
5	multicellular organismal water homeostasis	GO:050891	10.0	AQP4, AQP1
6	caveola assembly	GO:070836	10.0	CAV1, CAV2
7	negative regulation of endothelial cell proliferation	GO:001937	10.0	CAV1, CAV2, APOE
8	regulation of synaptic plasticity	GO:048167	9.9	PSEN2, PSEN1, PLAT
9	myeloid leukocyte differentiation	GO:002573	9.8	PSEN2, PSEN1
10	hemopoietic progenitor cell differentiation	GO:002244	9.8	PSEN2, PSEN1, TGFB1
11	mononuclear cell proliferation	GO:032943	9.3	ACE, TGFB1
12	response to glucocorticoid stimulus	GO:051384	9.0	BCHE, IL6, CAV1, PLAT
13	inflammatory response	GO:006954	8.8	TGFB1, OLR1, AOC3, IL6, IL1A, SERPINA3
14	response to hypoxia	GO:001666	8.4	PSEN2, TGFB1, PLAT, CAV1, IL1A, MMP9
15	response to drug	GO:042493	8.0	TGFB1, ABCG2, ABCB1, CAV1, AQP1, MMP9

Molecular functions related to cerebral amyloid angiopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	apolipoprotein binding	GO:034185	10.1	LRP1, MAPT, ABCA1
2	beta-amyloid binding	GO:001540	10.0	CST3, APOE, ITM2B, BCHE
3	syntaxin binding	GO:019905	9.5	ABCA1, CAV1, CAV2
4	endopeptidase activity	GO:004175	9.4	MME, ACE, PSEN1
5	protein homodimerization activity	GO:042803	8.7	PON1, TGFB1, ABCG2, CAV2, HSPB6, IDE
6	protein binding	GO:005515	3.5	CST3, TUBA1B, TUBB4A, PLAT, A2M, C1D