MCID: CRB086
MIFTS: 38

Cerebral Aneurysms malady

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Summaries for Cerebral Aneurysms

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44NINDS, 33MalaCards
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NINDS:44 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.

MalaCards: Cerebral Aneurysms, also known as cerebral aneurysm, is related to aneurysm and intracranial aneurysm. An important gene associated with Cerebral Aneurysms is MT-CO2 (mitochondrially encoded cytochrome c oxidase II), and among its related pathways are Cell adhesion ECM remodeling and Cell adhesion Cell matrix glycoconjugates. The compounds vancomycin and zymosan have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and liver, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Cerebral Aneurysms

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44NINDS, 45Novoseek, 62UMLS
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Aliases & Descriptions:

cerebral aneurysms 44
cerebral aneurysm 45 62


Related Diseases for Cerebral Aneurysms

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Aneurysms via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm31.9CST3, ELN, ELANE
2intracranial aneurysm30.6ELN, ELANE
3hyperhomocysteinemia29.9CST3, ELN
4cerebritis11.3
5thromboembolism10.5
6arteriovenous malformation10.4
7hydrocephalus10.3
8headache10.3
9endotheliitis10.3
10ischemia10.2
11fibromuscular dysplasia10.2
12thunderclap headache10.2
13alagille syndrome10.1
14carotid artery dissection10.1
15polycystic kidney disease10.1
16carotid artery occlusion10.1
17aseptic meningitis10.1
18polycystic liver disease10.1
19osteogenesis imperfecta10.1
20choriocarcinoma10.1
21cranial nerve palsy10.1
22hypertension10.1
23kidney disease10.1
24liver disease10.1
25meningitis10.1
26emphysema due to aat deficiency10.1ELANE
27gingivitis10.0ELANE, CST3
28ehlers-danlos syndrome10.0ELN, ELANE
29pulmonary emphysema10.0ELANE, ELN
30cutis laxa10.0ELN, ELANE
31wegener's granulomatosis10.0ELN, ELANE
32meningioma10.0IGFBP7, CST3
33primary pulmonary hypertension10.0ELN, ELANE
34arteriovenous fistula10.0
35neurofibromatosis10.0
36renovascular hypertension10.0
37relapsing polychondritis10.0
38parametritis10.0
39hereditary hemorrhagic telangiectasia10.0
40factor vii deficiency10.0
41meningocele10.0
42acromegaly10.0
43scotoma10.0
44polyarteritis nodosa10.0
45aortitis10.0
46median arcuate ligament syndrome10.0
47acquired immunodeficiency syndrome10.0
48malignant hyperthermia10.0
49myxosarcoma10.0
50gastric dilatation10.0

Graphical network of the top 20 diseases related to Cerebral Aneurysms:



Diseases related to cerebral aneurysms

Symptoms for Cerebral Aneurysms

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Drugs & Therapeutics for Cerebral Aneurysms

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cerebral Aneurysms

Search NIH Clinical Center for Cerebral Aneurysms

Genetic Tests for Cerebral Aneurysms

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Anatomical Context for Cerebral Aneurysms

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33MalaCards
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MalaCards organs/tissues related to Cerebral Aneurysms:

33
Brain, Endothelial, Liver, Kidney, Heart, Smooth muscle, Testes

Animal Models for Cerebral Aneurysms or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cerebral Aneurysms:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9KLF5, CST3, ELANE

Publications for Cerebral Aneurysms

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52PubMed
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Articles related to Cerebral Aneurysms:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Approximating hemodynamics of cerebral aneurysms with steady flow simulations. (24262847)
2014
2
The result of surgical treatment in patients with cerebral aneurysms in Maharaj Nakorn Chiang Mai Hospital: a report of 225 cases. (24319852)
2013
3
Rescue stenting in endovascular treatment of acutely ruptured cerebral aneurysms. (23472719)
2013
4
Complications of endovascular treatment of cerebral aneurysms. (23332977)
2013
5
An angiographic atlas of intracranial arterial diameters associated with cerebral aneurysms. (23946098)
2013
6
Stent-assisted coiling in endovascular treatment of 500 consecutive cerebral aneurysms with long-term follow-up. (23886748)
2013
7
Endovascular methods for the treatment of intracranial cerebral aneurysms. (24156851)
2013
8
Endovascular treatment of cerebral aneurysms using the hydrocoil embolic system. (24007730)
2013
9
Pediatric cerebral aneurysms. (24156864)
2013
10
Silent embolism after stent-assisted coiling of cerebral aneurysms: diffusion-weighted MRI study of 75 cases. (23929549)
2013
11
Simultaneous presentation of two cerebral aneurysms. (23269051)
2012
12
Treatment of ruptured and unruptured cerebral aneurysms in the USA: a paradigm shift. (21990481)
2012
13
Hospitalization costs for endovascular and surgical treatment of unruptured cerebral aneurysms in the United States are substantially higher than medicare payments. (22033718)
2012
14
Intra-luminal stent navigation for embolization of cerebral aneurysms with marked angular acuity of incorporated branch vasculature. (22521183)
2012
15
Angiographic CT with intravenous contrast injection compared with conventional rotational angiography in the diagnostic work-up of cerebral aneurysms. (22268091)
2012
16
Early and midterm results of complex cerebral aneurysms treated with Silk stent. (22695740)
2012
17
Annual rupture risk of growing unruptured cerebral aneurysms detected by magnetic resonance angiography. (22540400)
2012
18
Microembolic signal monitoring after coiling of unruptured cerebral aneurysms: an observational analysis of 123 cases. (21680657)
2011
19
Waffle-cone technique with Solitairea8c AB remodeling device: endovascular treatment of highly selected complex cerebral aneurysms. (20821314)
2011
20
Flow diversion for cerebral aneurysms: a cautionary tale. (21071535)
2011
21
Combined treatment with stenting and coiling for complex cerebral aneurysms: preliminary experience of twenty aneurysms treated by new generation intracranial stents. (24148541)
2010
22
Balloon-assisted extrasaccular coil embolization technique for the treatment of very small cerebral aneurysms. (19499982)
2010
23
Angiographic computed tomography and computed tomographic angiography techniques: actual interventional and diagnostic possibilities of their use in patients with cerebral aneurysms. (21577343)
2010
24
Symptomatic unruptured cerebral aneurysms: features and surgical outcome. (20885113)
2010
25
Application of the FlexiForce contact surface force sensor to continuous extraocular compression monitoring during craniotomy for cerebral aneurysms. (19816203)
2010
26
Role of shear stress in the blister formation of cerebral aneurysms. (20948401)
2010
27
Preliminary use of the Leo stent in the endovascular treatment of wide-necked cerebral aneurysms. (20849796)
2010
28
Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats. (19620512)
2009
29
Estimating continuous 4D wall motion of cerebral aneurysms from 3D rotational angiography. (20425981)
2009
30
Development of cranial nerve palsy shortly after endosaccular embolization for asymptomatic cerebral aneurysm: report of two cases and literature review. (19262981)
2009
31
Endovascular management of multiple cerebral aneurysms in acute subarachnoid hemorrhage associated with fenestrated basilar artery. A case report and literature review. (24256763)
2008
32
Endovascular and surgical treatment of ruptured cerebral aneurysms in pediatric patients. (19005375)
2008
33
Flat panel detector angiographic CT for stent-assisted coil embolization of broad-based cerebral aneurysms. (17893214)
2007
34
Completion angiography for surgically treated cerebral aneurysms: an economic analysis. (18162894)
2007
35
Role of image fusion combining three-dimensional digital subtraction angiography with magnetic resonance imaging in evaluation of unruptured cerebral aneurysms. (17427277)
2007
36
Endovascular management of cerebral aneurysms: work in progress. (17352339)
2007
37
Rebleeding of ruptured cerebral aneurysms during three-dimensional computed tomographic angiography: report of two cases and literature review. (17345112)
2007
38
The implications of ISAT and ISUIA for the management of cerebral aneurysms during pregnancy. (17508225)
2007
39
Nonlinear anisotropic stress analysis of anatomically realistic cerebral aneurysms. (17227102)
2007
40
Cerebral aneurysms. (16943405)
2006
41
Impaired progression of cerebral aneurysms in interleukin-1beta-deficient mice. (16439700)
2006
42
Model analysis of coil embolization of cerebral aneurysms: prediction of thrombus formation in aneurysms based on the coil embolization rate. (16551435)
2006
43
Central hyperthermia suspected of malignant hyperthermia in a patient undergoing radical neck clipping for cerebral aneurysm]. (15717469)
2005
44
Altered arterial homeostasis and cerebral aneurysms: a molecular epidemiology study. (15157303)
2004
45
Disruption of gene for inducible nitric oxide synthase reduces progression of cerebral aneurysms. (14615616)
2003
46
Development of the biologically active Guglielmi detachable coil for the treatment of cerebral aneurysms. Part II: an experimental study in a swine aneurysm model. (10588133)
1999
47
Prevalence of cerebral aneurysms in patients with fibromuscular dysplasia: a reassessment. (9488296)
1998
48
Collagen cross-linkage, elastolytic and collagenolytic activities in cerebral aneurysms: a preliminary investigation. (9698037)
1998
49
Are cerebral aneurysms atherosclerotic? (8165691)
1994
50
Multiple cerebral aneurysms associated with aortitis syndrome--case report. (7532804)
1994

Variations for Cerebral Aneurysms

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Expression for genes affiliated with Cerebral Aneurysms

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Aneurysms

Search GEO for disease gene expression data for Cerebral Aneurysms.

Pathways for genes affiliated with Cerebral Aneurysms

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50PathCards, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Cerebral Aneurysms according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1CST3, ELN
29.0ELN, ELANE

Compounds for genes affiliated with Cerebral Aneurysms

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Cerebral Aneurysms according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1vancomycin45 1110.7CST3, ELANE
2zymosan459.7CST3, ELANE
3polysulfone459.7CST3, ELANE
4cellulose acetate459.7ELANE, CST3
5leupeptin459.7ELANE, CST3
6captopril45 61 51 29 1113.7CST3, ELANE
7kininogen459.6CST3, ELANE
8rofecoxib45 51 29 1112.6MT-CO2, ELN
9aprotinin45 1110.6ELANE, CST3
10citrate459.6MT-CO2, ELANE
11isodesmosine459.4ELN, ELANE
12desmosine459.4ELN, ELANE
13tetrapeptide459.4ELN, CST3
14tannins459.4ELN, ELANE
15(4-aminophenyl)mercuric acetate459.4ELN, ELANE
16thermolysin459.4ELN, ELANE
17polyethylene glycol459.4CST3, ELN
18diisopropylfluorophosphate459.4ELANE, ELN
19alginate459.4ELN, ELANE
20dermatan sulfate459.3ELN, ELANE
21prostacyclin459.3ELANE, IGFBP7
22doxycycline45 1110.3ELN, ELANE
23sodium dodecylsulfate459.3ELN, ELANE
24copper45 2410.2MT-CO2, ELN
25sodium nitroprusside459.2ELN, ELANE
26hydrocortisone45 3 61 1112.2ELN, ELANE
27hyaluronic acid45 2410.1ELANE, ELN
28carbon458.9ELN, ELANE
29vitamin a45 24 1110.9ELANE, ELN, CST3
30fibrinogen458.9ELANE, ELN, CST3
31vegf458.8IGFBP7, ELN, CST3
32alanine458.8ELN, CST3, KLF5
33lactate458.5ELANE, ELN, MT-CO2, CST3
34estrogen458.4IGFBP7, ELANE, ELN, KLF5
35cysteine458.4ELANE, ELN, CST3, KLF5
36retinoic acid45 249.2IGFBP7, ELANE, ELN
37serine457.9IGFBP7, ELANE, ELN, CST3, KLF5

GO Terms for genes affiliated with Cerebral Aneurysms

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16Gene Ontology
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Cellular components related to Cerebral Aneurysms according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0CST3, ELN, ELANE, IGFBP7

Biological processes related to Cerebral Aneurysms according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.0ELN, ELANE

Molecular functions related to Cerebral Aneurysms according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3CST3, ELANE

Products for genes affiliated with Cerebral Aneurysms

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Aneurysms

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet