MCID: CRB086
MIFTS: 37

Cerebral Aneurysms malady

Summaries for Cerebral Aneurysms

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43NINDS, 32MalaCards
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NINDS:43 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.

MalaCards: Cerebral Aneurysms, also known as cerebral aneurysm, is related to intracranial aneurysm and aneurysm disease. An important gene associated with Cerebral Aneurysms is ELANE (elastase, neutrophil expressed), and among its related pathways are Collagen biosynthesis and modifying enzymes and Degradation of the extracellular matrix. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are integument and respiratory system.

Aliases & Classifications for Cerebral Aneurysms

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43NINDS, 44Novoseek, 60UMLS
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Aliases & Descriptions:

cerebral aneurysms 43
cerebral aneurysm 44 60


Related Diseases for Cerebral Aneurysms

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Aneurysms via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1intracranial aneurysm30.9ELN, ELANE, SERPINA1, COL1A2, PKD1
2aneurysm disease30.5TIMP2, CST3, PKD1, MMP14, MMP9, SERPINA1
3ischemia30.2MB, CST3, CHKB, MMP14, HMOX1, SELP
4polycystic kidney disease30.1PKD1
5meningitis30.1MMP9
6stroke, ischemic30.1SELP
7hypertension30.1CST3, AGTR1, REN, MMP9
8compartment syndrome29.9MB, CHKB
9polycystic kidney disease, autosomal dominant29.9REN, PKD1, CST3
10hyperhomocysteinemia29.9ELN, SELP, CST3
11renovascular hypertension29.9AGTR1, REN
12hepatitis29.9SELP, SERPINA1, TIMP2
13cerebritis11.3
14arteriovenous malformation10.4
15hydrocephalus10.3
16cerebral arteritis10.2
17cerebral palsy10.2
18cerebral artery occlusion10.2
19intracranial embolism10.2
20aseptic meningitis10.1
21carotid artery dissection10.1
22alagille syndrome10.1
23carotid artery occlusion10.1
24osteogenesis imperfecta10.1
25polycystic liver disease10.1
26aortic aneurysm10.1
27choriocarcinoma10.1
28cranial nerve palsy10.1
29kidney disease10.1
30liver disease10.1
31ruptured aortic aneurysm10.1
32myeloid leukemia10.0ELANE
33synovitis10.0TIMP2
34bronchopulmonary dysplasia10.0ELANE
35galactosemia10.0SERPINA1
36myeloma10.0CST3
37portal hypertension10.0REN
38leukemia10.0HMOX1
39sarcoma10.0MB
40neuropathy10.0MB
41malaria10.0MB
42obesity10.0HMOX1
43fibromuscular dysplasia10.0REN
44thromboembolism10.0SELP
45lichen sclerosus10.0ELN
46anuria10.0MB
47fibromyalgia10.0SERPINA1
48mitral valve prolapse10.0AGTR1
49interstitial lung disease10.0MMP9
50allergic rhinitis10.0PDE4A

Graphical network of the top 20 diseases related to Cerebral Aneurysms:



Diseases related to cerebral aneurysms

Clinical Features for Cerebral Aneurysms

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Drugs & Therapeutics for Cerebral Aneurysms

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebral Aneurysms

Drug clinical trials:

Search ClinicalTrials for Cerebral Aneurysms

Search NIH Clinical Center for Cerebral Aneurysms

Search CenterWatch for Cerebral Aneurysms

Genetic Tests for Cerebral Aneurysms

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Anatomical Context for Cerebral Aneurysms

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32MalaCards
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MalaCards organs/tissues related to Cerebral Aneurysms:

32
Brain

Animal Models for Cerebral Aneurysms or affiliated genes

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36MGI
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Publications for Cerebral Aneurysms

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Genetic Variations for Cerebral Aneurysms

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Expression for genes affiliated with Cerebral Aneurysms

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Aneurysms

Search GEO for disease gene expression data for Cerebral Aneurysms.

Pathways for genes affiliated with Cerebral Aneurysms

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53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Cerebral Aneurysms according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ELN, ELANE
2
Hide members
10.2ELANE, MMP9
3
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10.0MMP9, MMP14, TIMP2
410.0MMP9, CTSB, CST3
510.0MMP9, SELP, ELANE
69.9COL1A2, MMP9, HMOX1
7
Cell adhesion Cell-matrix glycoconjugates
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9.9TIMP2, MMP9, ELANE, ELN
8
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9.9COL1A2, TIMP2, CTSB, MMP14
99.8TIMP2, CTSB, REN, MMP9
109.8HMOX1, MMP9, REN, TIMP2
11
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9.7COL1A2, TIMP2, CTSB, MMP14, MMP9
12
Cell adhesion ECM remodeling
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9.6ELN, MMP9, MMP14, CST3, TIMP2, COL1A2

Compounds for genes affiliated with Cerebral Aneurysms

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cerebral Aneurysms according to GeneCards/GeneDecks:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CHKB, ELN
2cycloheximide4410.4ELN, PDE4A
3kininogen4410.3CTSB, REN, CST3
4(4-aminophenyl)mercuric acetate4410.3TIMP2, MMP9, ELN, ELANE
5dexamethasone44 49 28 1113.1PDE4A, REN, MMP14, MMP9
6alpha tocopherol4410.1ELANE, CHKB
7pge24410.1MMP9, MB, PDE4A, REN
8chymostatin4410.1AGTR1, MMP9, ELANE, REN
9aspartate4410.1CST3, ELN, CHKB, COL1A2, PDE4A
10desmosine4410.0ELN, ELANE, SERPINA1
11glutamate4410.0MB, AGTR1, CHKB, PKD1
12aprotinin44 1111.0SELP, TIMP2, MB, CTSB, ELANE
13norepinephrine44 11 2412.0ELANE, PDE4A, MB, CHKB, HMOX1
14nitroglycerin44 1110.9ELANE, AGTR1, SELP, REN, CHKB
15vitamin a44 11 2411.8MMP9, ELANE, SERPINA1, CST3, MB
16losartan44 49 28 1112.8REN, SELP, TIMP2, ELN, AGTR1
17fluvastatin44 49 28 1112.8MB, SELP, MMP9, CHKB, AGTR1
18polyethylene glycol449.8MB, CST3, CHKB, ELN, HMOX1
19theophylline44 28 11 2412.8CHKB, SELP, ELN, MB, PDE4A
20imidazole449.8HMOX1, PDE4A, AGTR1, MB, CTSB
21simvastatin44 49 59 28 11 2414.7COL1A2, SELP, HMOX1, CHKB, MMP9, AGTR1
22chloramphenicol44 2 1111.6ELN, ELANE, MMP9, MMP14, COL1A2, HMOX1
23heparin44 28 11 2412.5CHKB, SERPINA1, ELN, SELP, CTSB, MB
24paraffin449.5SERPINA1, TIMP2, MMP14, MB, CTSB, CHKB
25cyclosporin a44 28 5911.5TIMP2, PDE4A, CTSB, CHKB, HMOX1, CST3
26prostacyclin449.5ELANE, SELP, PDE4A, AGTR1, IGFBP7, REN
27aspirin44 49 28 2412.5PDE4A, AGTR1, CHKB, HMOX1, ELANE, SELP
28ascorbic acid44 2410.5ELN, SERPINA1, HMOX1, MB, TIMP2, CHKB
29n acetylcysteine449.4ELN, SELP, HMOX1, MMP9, CHKB, AGTR1
30actinomycin d449.4MMP9, ELN, HMOX1, TIMP2, PDE4A, CTSB
31oxygen44 2410.4ELANE, HMOX1, MMP14, CTSB, MB, PDE4A
32ly294002449.4COL1A2, TIMP2, PDE4A, CTSB, MMP14, MMP9
33sodium nitroprusside449.4ELANE, ELN, MB, PDE4A, AGTR1, REN
34epinephrine44 11 2411.4ELANE, SELP, MMP9, REN, CHKB, AGTR1
35cholesterol44 28 11 2412.2SELP, SERPINA1, MMP14, CHKB, TIMP2, CTSB
36glucose449.1CTSB, REN, IGFBP7, CHKB, AGTR1, CST3
37h2o2449.1CHKB, SERPINA1, AGTR1, CTSB, MB, ELANE
38fibrinogen449.1ELN, ELANE, SELP, SERPINA1, MMP9, MMP14
39lactate449.1CST3, HMOX1, MMP14, CHKB, MMP9, TIMP2
40nitric oxide44 11 2411.1SELP, SERPINA1, HMOX1, TIMP2, PDE4A, CTSB
41retinoic acid44 2410.0SELP, ELN, MMP9, TIMP2, PDE4A, CTSB
42creatinine449.0TIMP2, AGTR1, REN, MMP9, SERPINA1, SELP
43alanine449.0MMP14, CHKB, PKD1, AGTR1, CTSB, CST3
44superoxide44 249.9AGTR1, PDE4A, ELANE, HMOX1, CST3, CHKB
45serine448.9ELN, TIMP2, MMP9, MMP14, COL1A2, PDE4A
46arginine448.9REN, HMOX1, IKBKG, ELN, SELP, MB
47tyrosine448.7SERPINA1, SELP, MMP14, MMP9, COL1A2, TIMP2
48calcium44 49 11 2411.7CHKB, CST3, COL1A2, CTSB, AGTR1, TIMP2
49vegf448.4PDE4A, MB, CST3, CTSB, AGTR1, CHKB
50cysteine448.4ELN, SELP, SERPINA1, HMOX1, MMP9, MMP14

GO Terms for genes affiliated with Cerebral Aneurysms

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16Gene Ontology
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Cellular components related to Cerebral Aneurysms according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1TIMP2, CST3, CTSB, REN, MMP9, SERPINA1
2extracellular spaceGO:0056158.4SELP, COL1A2, TIMP2, CST3, CTSB, IGFBP7

Biological processes related to Cerebral Aneurysms according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:00201810.1REN, AGTR1
2endothelial cell proliferationGO:00193510.1HMOX1, MMP14
3regulation of blood pressureGO:0082179.9HMOX1, REN, COL1A2
4response to lipopolysaccharideGO:0324969.9REN, SERPINA1, SELP, ELANE
5collagen catabolic processGO:0305749.8COL1A2, CTSB, MMP14, MMP9, ELANE
6extracellular matrix disassemblyGO:0226179.8ELANE, MMP9, MMP14, CTSB, TIMP2, COL1A2
7kidney developmentGO:0018229.6REN, PKD1, AGTR1
8extracellular matrix organizationGO:0301989.6COL1A2, TIMP2, CTSB, MMP14, MMP9, ELANE
9proteolysisGO:0065089.6CTSB, REN, MMP14, MMP9, ELANE

Molecular functions related to Cerebral Aneurysms according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:00823310.0ELANE, REN, CTSB
2protease bindingGO:0020209.7ELANE, SERPINA1, CST3
3protein bindingGO:0055157.9ELN, KLF5, COL1A2, PDE4A, CST3, CTSB

Products for genes affiliated with Cerebral Aneurysms

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Aneurysms

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet