MCID: CRB004
MIFTS: 46

Cerebral Artery Occlusion

Categories: Cardiovascular diseases

Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 34 434 434.9
UMLS 69 C0028790

Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to infective endocarditis and arteries, anomalies of. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Abciximab and Fibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and cortex, and related phenotypes are cardiovascular system and cellular

Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 infective endocarditis 29.9 ODC1 TNF
2 arteries, anomalies of 29.3 IL1B NOS3 TNF
3 myocardial infarction 28.7 HIF1A IL1B NOS3 TNF
4 cerebritis 11.1
5 ischemia 10.5
6 neuronitis 10.4
7 brachial plexus lesion 10.3 BDNF GDNF
8 spinal cord disease 10.3 GDNF TNF
9 polyposis, gastric 10.3 IL1B TNF
10 paine syndrome 10.3 BDNF IL1B
11 systemic onset juvenile idiopathic arthritis 10.3 IL1B TNF
12 staphylococcal toxic shock syndrome 10.3 IL1B TNF
13 kashin-beck disease 10.3 IL1B TNF
14 burns 10.3 IL1B TNF
15 laryngitis 10.3 IL1B TNF
16 haemophilus influenzae 10.3 IL1B TNF
17 retinitis pigmentosa 60 10.3 IL1B TNF
18 actinic prurigo 10.3 IL1B TNF
19 poems syndrome 10.3 IL1B TNF
20 irritant dermatitis 10.3 IL1B TNF
21 crohn's colitis 10.3 IL1B TNF
22 burning mouth syndrome 10.3 IL1B TNF
23 central nervous system vasculitis 10.3 IL1B TNF
24 dental pulp disease 10.3 IL1B TNF
25 stachybotrys chartarum 10.3 IL1B TNF
26 early-onset schizophrenia 10.3 BDNF TNF
27 eales disease 10.3 IL1B TNF
28 blau syndrome 10.3 IL1B TNF
29 traumatic brain injury 10.3 BDNF HIF1A
30 endometritis 10.2 IL1B TNF
31 pulpitis 10.2 IL1B TNF
32 scrub typhus 10.2 IL1B TNF
33 hydrops, lactic acidosis, and sideroblastic anemia 10.2
34 lacrimal apparatus disease 10.2 IL1B TNF
35 pleural disease 10.2 IL1B TNF
36 middle ear disease 10.2 IL1B TNF
37 q fever 10.2 IL1B TNF
38 viral encephalitis 10.2 IL1B TNF
39 perinatal necrotizing enterocolitis 10.2 IL1B TNF
40 commensal bacterial infectious disease 10.2 IL1B TNF
41 brain injury 10.2
42 brain edema 10.2
43 palindromic rheumatism 10.2 IL1B TNF
44 acute respiratory distress syndrome 10.2 IL1B TNF
45 extrinsic cardiomyopathy 10.2 IL1B TNF
46 retinal ischemia 10.2 HIF1A TNF
47 purulent labyrinthitis 10.1 IL1B NOS3
48 ischemic heart disease 10.1 NOS3 TNF
49 chikungunya 10.1 IL1B TNF
50 spinal cord injury 10.1 BDNF GDNF TNF

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion

Symptoms & Phenotypes for Cerebral Artery Occlusion

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 IL1B IL1RN NOS3 EPHA3 TNF GDNF
2 cellular MP:0005384 9.87 HIF1A IL1RN NOS3 BDNF ODC1 TNF
3 growth/size/body region MP:0005378 9.76 IL1B IL1RN NOS3 BDNF ODC1 TNF
4 digestive/alimentary MP:0005381 9.65 HIF1A NOS3 BDNF TNF GDNF
5 mortality/aging MP:0010768 9.61 IL1B IL1RN NOS3 BDNF ODC1 EPHA3
6 respiratory system MP:0005388 9.02 HIF1A NOS3 BDNF EPHA3 TNF

Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
3 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
4 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2
5 Anticoagulants Phase 4,Phase 2
6 Plasminogen Phase 4,Phase 2
7 Antibodies Phase 4
8 Antibodies, Monoclonal Phase 4
9 Immunoglobulin Fab Fragments Phase 4
10 Immunoglobulins Phase 4
11
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
12
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
13
Ticlopidine Approved Phase 3 55142-85-3 5472
14 Analgesics Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antipyretics Phase 3
19 Antirheumatic Agents Phase 3
20 Cyclooxygenase Inhibitors Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 3
22 Neurotransmitter Agents Phase 3
23 Peripheral Nervous System Agents Phase 3
24 Purinergic P2 Receptor Antagonists Phase 3
25 Purinergic P2Y Receptor Antagonists Phase 3
26
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
27
Iron Approved Phase 2 7439-89-6 23925
28
Argatroban Approved, Investigational Phase 2 74863-84-6 152951
29
Tenecteplase Approved Phase 2 191588-94-0
30 Chelating Agents Phase 2
31 Iron Chelating Agents Phase 2
32 Pharmaceutical Solutions Phase 2
33 Antithrombin III Phase 2
34 Antithrombins Phase 2
35 HIV Protease Inhibitors Phase 2
36
protease inhibitors Phase 2
37 Serine Proteinase Inhibitors Phase 2
38 serine Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
2 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
3 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
4 Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion Unknown status NCT00336596 Phase 3
5 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
6 Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke Completed NCT02448069 Phase 2 Argatroban
7 Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion Not yet recruiting NCT02338466 Phase 2 rt-PA;tenecteplase
8 Use of Hypothermia During Robotic Prostatectomy Unknown status NCT00915031
9 Neurothrombectomy France Completed NCT02880579
10 Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase Terminated NCT02216565 Alteplase if patient is eligible

Search NIH Clinical Center for Cerebral Artery Occlusion

Genetic Tests for Cerebral Artery Occlusion

Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

38
Brain, Endothelial, Cortex, Bone, Bone Marrow, Retina, Thalamus

Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 684)
# Title Authors Year
1
The degree of leukoaraiosis predicts clinical outcomes and prognosis in patients with middle cerebral artery occlusion after intravenous thrombolysis. ( 29288062 )
2018
2
Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion. ( 29353043 )
2018
3
Licorice Pretreatment Protects Against Brain Damage Induced by Middle Cerebral Artery Occlusion in Mice. ( 29341803 )
2018
4
MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes. ( 29401609 )
2018
5
Ischemia Reperfusion Injury after Gradual versus Rapid Flow Restoration for Middle Cerebral Artery Occlusion Rats. ( 29374244 )
2018
6
Middle Cerebral Artery Occlusion by an Intraluminal Suture Method. ( 29222799 )
2018
7
Long non-coding RNA RMST silencing protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke. ( 29258823 )
2018
8
Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion. ( 29354885 )
2018
9
Protective effects of beef decoction rich in carnosine on cerebral ischemia injury by permanent middle cerebral artery occlusion in rats. ( 29399121 )
2018
10
Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of fluid-attenuated inversion recovery vascular hyperintensity scores. ( 29451209 )
2018
11
Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion. ( 29354887 )
2018
12
Targeted Temperature Management at 33A^C or 36A^C Produces Equivalent Neuroprotective Effects in the Middle Cerebral Artery Occlusion Rat Model of Ischemic Stroke. ( 29337840 )
2018
13
Myricetin against ischemic cerebral injury in rat middle cerebral artery occlusion model. ( 29257250 )
2018
14
Dipyridamole plus Triflusal versus Triflusal Alone in Infarct Reduction after Middle Cerebral Artery Occlusion. ( 29338983 )
2018
15
Mechanical Thrombectomy of Acute Middle Cerebral Artery Occlusion using Trans-Anterior Communicating Artery Approach. ( 29339323 )
2018
16
Leptomeningeal collateral status predicts outcome after middle cerebral artery occlusion. ( 28905995 )
2017
17
A Case of Acute Isolated Posterior Cerebral Artery Occlusion Successfully Treated with Endovascular Clot Aspiration. ( 28664028 )
2017
18
MRI Mouse Brain Data of Ischemic Lesion after Transient Middle Cerebral Artery Occlusion. ( 28932191 )
2017
19
Clinical Manifestations of Isolated Chronic Middle Cerebral Artery Occlusion in Relation to Angiographic Features. ( 28893698 )
2017
20
Hyperglycemia decreases preoxiredoxin-2 expression in a middle cerebral artery occlusion model. ( 28747974 )
2017
21
Metabolite changes in the ipsilateral and contralateral cerebral hemispheres in rats with middle cerebral artery occlusion. ( 28761426 )
2017
22
Successful Revascularization of Acute Middle Cerebral Artery Occlusion by Intravenous Thrombolysis While on Apixaban. ( 28615907 )
2017
23
Assessment of the Neuroprotective Effects of Arginine-Rich Protamine Peptides, Poly-Arginine Peptides (R12-Cyclic, R22) and Arginine-Tryptophan-Containing Peptides Following In Vitro Excitotoxicity and/or Permanent Middle Cerebral Artery Occlusion in Rats. ( 28523591 )
2017
24
Hypothermia exerts early neuroprotective effects involving protein conjugation of SUMOa892/3 in a rat model of middle cerebral artery occlusion. ( 28713891 )
2017
25
Hyperglycemia reduces PP2A subunit B expression in a middle cerebral artery occlusion animal model. ( 28652527 )
2017
26
Early Thrombectomy of a Proximal Middle Cerebral Artery Occlusion Leading to Complete Recovery with No Infarct. ( 28559829 )
2017
27
Transfusion of Polynitroxylated Pegylated Hemoglobin Stabilizes Pial Arterial Dilation and Decreases Infarct Volume After Transient Middle Cerebral Artery Occlusion. ( 28899897 )
2017
28
Spontaneous recanalization of atherosclerotic middle cerebral artery occlusion: Case report. ( 28682888 )
2017
29
Subacute endovascular recanalization of symptomatic cerebral artery occlusion: a propensity score-matched analysis. ( 28899866 )
2017
30
Safe time duration for temporary middle cerebral artery occlusion in aneurysm surgery based on motor-evoked potential monitoring. ( 28584682 )
2017
31
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats. ( 28518065 )
2017
32
Acute Cerebral Artery Occlusion by a Calcified Embolus with False Patency Sign on Computed Tomographic Angiography. ( 27789151 )
2017
33
The Pyk2/MCU pathway in the rat middle cerebral artery occlusion model of ischemic stroke. ( 28916471 )
2017
34
Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring. ( 29363906 )
2017
35
Therapeutic effects of oral dimethyl fumarate on stroke induced by middle cerebral artery occlusion: An animal experimental study. ( 28506000 )
2017
36
Quercetin attenuates the injury-induced reduction of I^-enolase expression in a middle cerebral artery occlusion animal model. ( 29399028 )
2017
37
Effects of crenolanib, a non-selective inhibitor of PDGFR, in a mouse model of transient middle cerebral artery occlusion. ( 28943249 )
2017
38
Infarct morphology assessment in patients with carotid artery/middle cerebral artery occlusion using fast fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH). ( 29190679 )
2017
39
Neuroprotective effect of lercanidipine in middle cerebral artery occlusion model of stroke in rats. ( 27794423 )
2017
40
Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models. ( 29246244 )
2017
41
The effect of exercise preconditioning on stroke outcome in ovariectomized mice with permanent middle cerebral artery occlusion. ( 28873322 )
2017
42
A small dose of apomorphine counteracts the deleterious effects of middle cerebral artery occlusion in different models. ( 29220863 )
2017
43
Intravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats. ( 28059661 )
2017
44
Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat. ( 27639457 )
2016
45
Neuroprotective Properties of a Macrolide Antibiotic in a Mouse Model of Middle Cerebral Artery Occlusion: Characterization of the Immunomodulatory Effects and Validation of the Efficacy of Intravenous Administration. ( 27392039 )
2016
46
Neuroprotective effects of Chrysophanol against inflammation in middle cerebral artery occlusion mice. ( 27450437 )
2016
47
Determinants of leptomeningeal collateral flow in stroke patients with a middle cerebral artery occlusion. ( 27438804 )
2016
48
Progesterone treatment shows greater protection in brain vs. retina in a rat modelA of middle cerebral artery occlusion: Progesterone receptor levels may play an important role. ( 27802245 )
2016
49
Cerebral Arterial Occlusion Did Not Promote the Prevalence of Cerebral Amyloid Angiopathy. ( 27497483 )
2016
50
Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice. ( 28060307 )
2016

Variations for Cerebral Artery Occlusion

Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 BDNF EPHA3 GDNF IL1B NOS3 TNF
2
Show member pathways
13.1 BDNF EPHA3 IL1B NOS3 TNF
3
Show member pathways
13.02 GDNF HIF1A IL1B IL1RN TNF
4 11.72 IL1B NOS3 TNF
5 11.55 HIF1A IL1B TNF
6 11.43 IL1B NOS3 TNF
7 11.34 BDNF GDNF IL1B TNF
8 11.23 BDNF HIF1A IL1B IL1RN TNF
9
Show member pathways
11.22 IL1B TNF
10 11.12 IL1B TNF
11 11.11 IL1B TNF
12 11.05 IL1B TNF
13 11.03 IL1B TNF
14 11.02 IL1B IL1RN TNF
15 11 IL1B TNF
16 10.87 HIF1A NOS3
17 10.8 IL1B TNF
18 10.68 BDNF EPHA3 IL1B TNF
19 10.57 IL1B TNF

GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 BDNF EPHA3 GDNF IL1B IL1RN TNF

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.8 GDNF IL1B TNF
2 positive regulation of angiogenesis GO:0045766 9.71 HIF1A IL1B NOS3
3 negative regulation of neuron apoptotic process GO:0043524 9.7 BDNF GDNF HIF1A
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 IL1B TNF
5 positive regulation of blood vessel endothelial cell migration GO:0043536 9.62 HIF1A NOS3
6 positive regulation of phagocytosis GO:0050766 9.61 IL1B TNF
7 neural crest cell migration GO:0001755 9.61 GDNF HIF1A
8 positive regulation of interleukin-8 production GO:0032757 9.6 IL1B TNF
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.59 HIF1A IL1B
10 regulation of nitric-oxide synthase activity GO:0050999 9.58 IL1B NOS3
11 positive regulation of NF-kappaB import into nucleus GO:0042346 9.58 IL1B TNF
12 positive regulation of chemokine production GO:0032722 9.57 HIF1A TNF
13 negative regulation of lipid catabolic process GO:0050995 9.56 IL1B TNF
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 IL1B TNF
15 regulation of receptor activity GO:0010469 9.55 BDNF GDNF IL1B IL1RN TNF
16 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.51 HIF1A IL1B
17 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.49 IL1B TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 IL1B TNF
19 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
20 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
21 fever generation GO:0001660 9.4 IL1B IL1RN
22 positive regulation of fever generation GO:0031622 9.37 IL1B TNF
23 sequestering of triglyceride GO:0030730 9.32 IL1B TNF
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
25 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.13 GDNF IL1B TNF
26 lipopolysaccharide-mediated signaling pathway GO:0031663 8.8 IL1B NOS3 TNF

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL1B IL1RN TNF
2 interleukin-1 receptor binding GO:0005149 8.62 IL1B IL1RN

Sources for Cerebral Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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