MCID: CRB008
MIFTS: 42

Cerebral Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Cerebral Atherosclerosis

MalaCards integrated aliases for Cerebral Atherosclerosis:

Name: Cerebral Atherosclerosis 12 51 14 69
Intracranial Arteriosclerosis 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12720
ICD10 32 I67.2
ICD9CM 34 437.0
MeSH 41 D002537
NCIt 46 C34459
UMLS 69 C0007775

Summaries for Cerebral Atherosclerosis

MalaCards based summary : Cerebral Atherosclerosis, also known as intracranial arteriosclerosis, is related to stroke, ischemic and sleep apnea. An important gene associated with Cerebral Atherosclerosis is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Selenium Micronutrient Network. The drugs Cilostazol and Probucol have been mentioned in the context of this disorder. Affiliated tissues include brain, smooth muscle and globus pallidus, and related phenotypes are Increased LDL uptake and cardiovascular system

Wikipedia : 72 Cerebral atherosclerosis is a type of atherosclerosis where build-up of plaque in the blood vessels of... more...

Related Diseases for Cerebral Atherosclerosis

Diseases related to Cerebral Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 stroke, ischemic 29.7 ACE APOE MTHFR
2 sleep apnea 29.4 ACE APOE
3 coronary heart disease 1 29.2 ACE APOA1 APOE
4 cerebrovascular disease 28.8 ACE APOA1 APOE MTHFR
5 vascular disease 28.8 ACE APOA1 APOE MTHFR
6 intracranial arteriosclerosis 12.2
7 cerebritis 10.7
8 moderate and severe traumatic brain injury 10.3 ACE APOE
9 retinal artery occlusion 10.3 ACE MTHFR
10 generalized atherosclerosis 10.3 ACE APOE
11 arteritic anterior ischemic optic neuropathy 10.2 ACE MTHFR
12 aortic atherosclerosis 10.2 ACE APOE
13 exfoliation syndrome 10.2 APOE MTHFR
14 hemorrhage, intracerebral 10.2 ACE APOE
15 familial lcat deficiency 10.2 APOA1 APOE
16 nephrosclerosis 10.2 ACE MTHFR
17 hepatic lipase deficiency 10.2 APOA1 APOE
18 ischemic optic neuropathy 10.2 ACE MTHFR
19 leukodystrophy, hypomyelinating, 3 10.2 APOA1 APOE
20 hypobetalipoproteinemia, familial, 1 10.2 APOA1 APOE
21 hyperlipoproteinemia, type iv 10.2 APOA1 APOE
22 hypolipoproteinemia 10.2 APOA1 APOE
23 nonarteritic anterior ischemic optic neuropathy 10.2 ACE MTHFR
24 hypertriglyceridemia, familial 10.2 APOA1 APOE
25 aging 10.2
26 arcus corneae 10.1 APOA1 APOE
27 hyperlipoproteinemia, type iii 10.1 APOA1 APOE
28 hyperlipidemia, familial combined 10.1 APOA1 APOE
29 migraine with aura 10.1 ACE MTHFR
30 hyperalphalipoproteinemia 1 10.1 APOA1 APOE
31 abetalipoproteinemia 10.1 APOA1 APOE
32 lecithin:cholesterol acyltransferase deficiency 10.1 APOA1 APOE
33 gallbladder disease 10.1 APOA1 APOE
34 tangier disease 10.0 APOA1 APOE
35 inherited metabolic disorder 10.0 APOA1 MTHFR
36 familial hyperlipidemia 10.0 APOA1 APOE
37 cerebral palsy 10.0 APOE MTHFR
38 carotid stenosis 10.0 ACE APOE MTHFR
39 vascular dementia 10.0 ACE APOE MTHFR
40 fibromuscular dysplasia 9.9 ACE RNF213
41 coronary stenosis 9.9 ACE APOA1 APOE
42 carotid artery disease 9.9 ACE APOA1 APOE
43 lipid metabolism disorder 9.9 ACE APOA1 APOE
44 atherosclerosis susceptibility 9.9 ACE APOA1 APOE
45 arteriosclerosis 9.9 ACE APOA1 APOE
46 aortic aneurysm, familial abdominal, 1 9.9 ACE APOE
47 alzheimer disease 9.8
48 cerebral arterial disease 9.8 RNF213 RPSA
49 moyamoya disease 1 9.8 RNF213 RPSA
50 peripheral vascular disease 9.6 ACE APOA1

Comorbidity relations with Cerebral Atherosclerosis via Phenotypic Disease Network (PDN): (show all 42)


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Aortic Valve Disease 1
Basilar Artery Insufficiency Benign Essential Hypertension
Borderline Personality Disorder Bronchitis
Bronchopneumonia Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypertensive Encephalopathy
Hypoglycemia Hypothyroidism
Intracranial Embolism Intracranial Thrombosis
Iron Deficiency Anemia Ischemic Heart Disease
Major Depressive Disorder Malignant Essential Hypertension
Osteoporosis Parkinson Disease, Late-Onset
Peripheral Vascular Disease Protein-Energy Malnutrition
Pseudobulbar Palsy Schizophreniform Disorder
Sinoatrial Node Disease Status Epilepticus
Swallowing Disorders Transient Cerebral Ischemia
Vascular Dementia Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Cerebral Atherosclerosis:



Diseases related to Cerebral Atherosclerosis

Symptoms & Phenotypes for Cerebral Atherosclerosis

GenomeRNAi Phenotypes related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 APOA1 APOE

MGI Mouse Phenotypes related to Cerebral Atherosclerosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 ACE APOA1 APOE RNF213 RPSA
2 endocrine/exocrine gland MP:0005379 9.02 ACE APOA1 APOE RNF213 RPSA

Drugs & Therapeutics for Cerebral Atherosclerosis

Drugs for Cerebral Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
2
Probucol Approved, Investigational Phase 4 23288-49-5 4912
3
Amlodipine Approved Phase 4 88150-42-9 2162
4
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
5
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
6 Anti-Asthmatic Agents Phase 4
7 Anticholesteremic Agents Phase 4
8 Antimetabolites Phase 4
9 Antioxidants Phase 4
10 Autonomic Agents Phase 4
11 Bronchodilator Agents Phase 4
12 Fibrinolytic Agents Phase 4
13 Hypolipidemic Agents Phase 4
14 Lipid Regulating Agents Phase 4
15 Neuroprotective Agents Phase 4
16 Peripheral Nervous System Agents Phase 4
17 Phosphodiesterase 3 Inhibitors Phase 4
18 Phosphodiesterase Inhibitors Phase 4
19 Platelet Aggregation Inhibitors Phase 4
20 Protective Agents Phase 4
21 Respiratory System Agents Phase 4
22 Vasodilator Agents Phase 4
23 Angiotensin II Type 1 Receptor Blockers Phase 4
24 Angiotensin Receptor Antagonists Phase 4
25 Angiotensinogen Phase 4
26 Antihypertensive Agents Phase 4
27 calcium channel blockers Phase 4
28 Calcium, Dietary Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
2 Trial Comparing Metabolic Effects of Telmisartan and Amlodipine on Hypertensive Patients With Obesity and Diabetes Completed NCT00847262 Phase 4 Temisartan;Amlodipine
3 Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis Recruiting NCT02315924

Search NIH Clinical Center for Cerebral Atherosclerosis

Cochrane evidence based reviews: intracranial arteriosclerosis

Genetic Tests for Cerebral Atherosclerosis

Anatomical Context for Cerebral Atherosclerosis

MalaCards organs/tissues related to Cerebral Atherosclerosis:

38
Brain, Smooth Muscle, Globus Pallidus, Endothelial, Heart

Publications for Cerebral Atherosclerosis

Articles related to Cerebral Atherosclerosis:

(show top 50) (show all 135)
# Title Authors Year
1
Ethnic Differences in Intracranial Artery Tortuosity: A Possible Reason for Different Locations of Cerebral Atherosclerosis. ( 29402073 )
2018
2
Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis? ( 28168435 )
2017
3
Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. ( 28319156 )
2017
4
Proteomic analysis and comparison of intraa89 and extracranial cerebral atherosclerosis responses to hyperlipidemia in rabbits. ( 28677755 )
2017
5
Interarm Systolic and Diastolic Blood Pressure Difference Is Diversely Associated With Cerebral Atherosclerosis in Noncardioembolic Stroke Patients. ( 28985258 )
2017
6
Intake of antioxidants and B vitamins is inversely associated with ischemic stroke and cerebral atherosclerosis. ( 27698959 )
2016
7
Location of cerebral atherosclerosis: Why is there a difference between East and West? ( 27145795 )
2016
8
Value of higher-resolution MRI in assessing middle cerebral atherosclerosis and predicting capsular warning syndrome. ( 27080075 )
2016
9
A pathological perspective on the natural history of cerebral atherosclerosis. ( 25854637 )
2015
10
Letter by Tsuda regarding article, "Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction". ( 24448990 )
2014
11
Response to letter regarding article, "Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction". ( 24448989 )
2014
12
Susceptibility vessel signs on T2*-weighted gradient echo images in patients with cerebral atherosclerosis. ( 25231582 )
2014
13
Different impact of hyperhomocysteinemia on cerebral small vessel ischemia and cervico-cerebral atherosclerosis in non-stroke individuals. ( 23218488 )
2013
14
Relationship between Cerebral Atherosclerosis and Leukoaraiosis in Aged Patients: Results from DSA. ( 24033698 )
2013
15
Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction. ( 24021686 )
2013
16
Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes. ( 23887837 )
2013
17
Nonrelevant cerebral atherosclerosis is a strong prognostic factor in acute cerebral infarction. ( 23686972 )
2013
18
Elevated AI^42 in aged, non-demented individuals with cerebral atherosclerosis. ( 23919773 )
2013
19
The association between cerebral atherosclerosis and arterial stiffness in acute ischemic stroke. ( 21974846 )
2011
20
Increases in cerebral atherosclerosis according to CHADS2 scores in patients with stroke with nonvalvular atrial fibrillation. ( 21350200 )
2011
21
Plasma total homocysteine and the methylenetetrahydrofolate reductase 677C>T polymorphism do not contribute to the distribution of cervico-cerebral atherosclerosis in ischaemic stroke patients. ( 20825473 )
2011
22
Gender differences in risk factors for intracranial cerebral atherosclerosis among asymptomatic subjects. ( 21497768 )
2011
23
Cerebral atherosclerosis causes neurodegenerative diseases. ( 20037498 )
2010
24
Endothelial function in lacunar infarction: a comparison of lacunar infarction, cerebral atherosclerosis and control group. ( 19556769 )
2009
25
Intracranial angioplasty and stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. ( 19560016 )
2009
26
Large vessel cerebral atherosclerosis is not in direct association with neuropathological lesions of Alzheimer's disease. ( 19521084 )
2009
27
Classic risk factors for atherosclerosis are not major determinants for location of extracranial or intracranial cerebral atherosclerosis. ( 19169042 )
2009
28
Risk factors of intracranial cerebral atherosclerosis among asymptomatics. ( 17690548 )
2007
29
Correlation of coronary and cerebral atherosclerosis: difference between extracranial and intracranial arteries. ( 16340186 )
2006
30
Intracranial angioplasty and stenting for cerebral atherosclerosis: new treatments for stroke are needed! ( 16622698 )
2006
31
Intracranial angioplasty & stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. ( 16221663 )
2005
32
Intracranial angioplasty & stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. ( 16223717 )
2005
33
Intracranial angioplasty and stent placement for cerebral atherosclerosis. ( 15101521 )
2004
34
Cerebral atherosclerosis and oxidative stress in Alzheimer's disease. ( 14757939 )
2003
35
Cerebral atherosclerosis and mild Alzheimer's disease. ( 12855821 )
2003
36
Cerebral atherosclerosis and coronary calcification. ( 12364716 )
2002
37
Cerebral atherosclerosis as predictor of stroke and mortality in representative elderly population. ( 11779914 )
2002
38
Cerebral atherosclerosis causes neurogenic hypertension. ( 11988586 )
2002
39
Cerebral atherosclerosis occurs spontaneously in homozygous WHHL rabbits. ( 11368997 )
2001
40
Early lesions of cerebral atherosclerosis from induced hypertension in Watanabe heritable hyperlipidemic rabbits. ( 11193506 )
2000
41
The influence of the degree of cerebral atherosclerosis on the changes in hemostatic system in patients with ischemic brain disease and atherosclerotic encephalopathy. ( 10645149 )
1999
42
Relation of plasma homocyst(e)ine to cerebral infarction and cerebral atherosclerosis. ( 9836754 )
1998
43
Cerebral atherosclerosis in Parkinsonian patients. ( 18591095 )
1998
44
The lipoprotein profile of young adults with cerebral atherosclerosis. ( 9031424 )
1996
45
Granule-laden perivascular cells observed in rabbits with experimental cerebral atherosclerosis. ( 8619506 )
1996
46
Association between deletion polymorphism of the angiotensin-converting enzyme gene and cerebral atherosclerosis. ( 8704045 )
1996
47
Race and sex differences in the distribution of cerebral atherosclerosis. ( 8898801 )
1996
48
Enhancement of the intracranial arterial wall at MR imaging: relationship to cerebral atherosclerosis. ( 7824729 )
1995
49
Pathology of cerebral atherosclerosis. Influence of age, race, and gender. ( 8249014 )
1993
50
The effects of hypertension on cerebral atherosclerosis in the cynomolgus monkey. ( 8342199 )
1993

Variations for Cerebral Atherosclerosis

Expression for Cerebral Atherosclerosis

Search GEO for disease gene expression data for Cerebral Atherosclerosis.

GO Terms for Cerebral Atherosclerosis

Cellular components related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.61 APOA1 APOE RPSA
2 extracellular vesicle GO:1903561 9.46 APOA1 APOE
3 high-density lipoprotein particle GO:0034364 9.4 APOA1 APOE
4 very-low-density lipoprotein particle GO:0034361 9.37 APOA1 APOE
5 endocytic vesicle lumen GO:0071682 9.32 APOA1 APOE
6 low-density lipoprotein particle GO:0034362 9.26 APOA1 APOE
7 chylomicron GO:0042627 9.16 APOA1 APOE
8 intermediate-density lipoprotein particle GO:0034363 8.96 APOA1 APOE
9 discoidal high-density lipoprotein particle GO:0034365 8.62 APOA1 APOE

Biological processes related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cholesterol metabolic process GO:0008203 9.58 APOA1 APOE
2 cholesterol homeostasis GO:0042632 9.57 APOA1 APOE
3 retinoid metabolic process GO:0001523 9.56 APOA1 APOE
4 triglyceride homeostasis GO:0070328 9.55 APOA1 APOE
5 triglyceride catabolic process GO:0019433 9.54 APOA1 APOE
6 lipoprotein metabolic process GO:0042157 9.52 APOA1 APOE
7 cholesterol efflux GO:0033344 9.51 APOA1 APOE
8 reverse cholesterol transport GO:0043691 9.49 APOA1 APOE
9 high-density lipoprotein particle remodeling GO:0034375 9.48 APOA1 APOE
10 high-density lipoprotein particle assembly GO:0034380 9.46 APOA1 APOE
11 phospholipid efflux GO:0033700 9.43 APOA1 APOE
12 chylomicron assembly GO:0034378 9.4 APOA1 APOE
13 positive regulation of cholesterol esterification GO:0010873 9.37 APOA1 APOE
14 chylomicron remodeling GO:0034371 9.32 APOA1 APOE
15 high-density lipoprotein particle clearance GO:0034384 9.26 APOA1 APOE
16 neuron projection regeneration GO:0031102 9.16 APOA1 APOE
17 regulation of Cdc42 protein signal transduction GO:0032489 8.96 APOA1 APOE
18 lipoprotein biosynthetic process GO:0042158 8.62 APOA1 APOE

Molecular functions related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.37 APOA1 APOE
2 cholesterol binding GO:0015485 9.32 APOA1 APOE
3 lipid transporter activity GO:0005319 9.26 APOA1 APOE
4 cholesterol transporter activity GO:0017127 9.16 APOA1 APOE
5 lipoprotein particle binding GO:0071813 8.96 APOA1 APOE
6 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 8.62 APOA1 APOE

Sources for Cerebral Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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