MCID: CRB088
MIFTS: 44

Cerebral Atrophy malady

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Summaries for Cerebral Atrophy

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44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means loss of cells. In brain tissue, atrophy describes a loss of neurons and the connections between them. Atrophy can be generalized, which means that all of the brain has shrunk; or it can be focal, affecting only a limited area of the brain and resulting in a decrease of the functions that area of the brain controls. If the cerebral hemispheres (the two lobes of the brain that form the cerebrum) are affected, conscious thought and voluntary processes may be impaired.

MalaCards: Cerebral Atrophy is related to dementia and parkinson's disease. An important gene associated with Cerebral Atrophy is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways are Signaling by NOTCH2 and Circadian Clock. The compounds fluorochrome and quisqualate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related mouse phenotypes are muscle and growth/size/body.

Wikipedia:65 Cerebral atrophy is a common feature of many of the diseases that affect the brain.Atrophy of any tissue... more...

Aliases & Classifications for Cerebral Atrophy

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44NINDS, 62UMLS
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Aliases & Descriptions:

cerebral atrophy 44 62


Related Diseases for Cerebral Atrophy

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.9GFAP, APOE, RPS27A, MAPT
2parkinson's disease30.5MAPT, RPS27A, APOE
3alzheimer's disease30.5GFAP, APOE, RPS27A, MAPT, CREB1
4huntington's disease30.3RPS27A, MAPT, CREB1
5progressive supranuclear palsy30.2MAPT, RPS27A, APOE
6multiple system atrophy30.1GFAP, RPS27A, MAPT
7frontotemporal dementia30.1APOE, RPS27A, MAPT
8primary progressive aphasia30.0RPS27A, MAPT
9tauopathy29.9RPS27A, MAPT
10motor neuron disease29.9MAPT, RPS27A
11amyotrophic lateral sclerosis29.9GFAP, RPS27A, MAPT
12vascular dementia29.8APOE, RPS27A, MAPT
13creutzfeldt-jakob disease29.8MAPT, RPS27A, APOE
14aicardi-goutieres syndrome29.8TREX1, SAMHD1, RNASEH2C, RNASEH2A, RNASEH2B
15memory impairment29.8CREB1, MAPT, APOE
16cerebrovascular disease29.8CREB1, MAPT, APOE
17cerebritis11.2
18multiple sclerosis10.6
19hydrocephalus10.5
20schizophrenia10.4
21keratosis follicularis dwarfism and cerebral atrophy10.4
22normal pressure hydrocephalus10.3
23brain injury10.3
24anorexia nervosa10.3
25systemic lupus erythematosus10.2
26hypertension10.2
27lupus erythematosus10.2
28retinitis10.2
29traumatic brain injury10.2
30atherosclerosis10.2
31head injury10.2
32x-linked intellectual disability - dysmorphism - cerebral atrophy10.2
33chilblain lupus10.1TREX1
34neuronal intranuclear inclusion disease10.1RPS27A
35acquired immunodeficiency syndrome10.1
36secondary progressive multiple sclerosis10.1
37aphasia10.1
38neuropathy10.1
39mental retardation10.1
40autosomal recessive cerebral atrophy10.1
41semantic dementia10.1RPS27A, MAPT
42inclusion body myositis10.1MAPT, RPS27A
43alexander disease10.0GFAP, RPS27A
44dentatorubral-pallidoluysian atrophy10.0RPS27A, CREB1
45alcohol abuse10.0RPS27A, CREB1
46spinocerebellar ataxia10.0MAPT, RPS27A
47movement disease10.0MAPT, RPS27A
48age related macular degeneration10.0APOE
49binswanger's disease10.0GFAP, MAPT
50hemorrhage, intracerebral10.0APOE, RPS27A

Graphical network of the top 20 diseases related to Cerebral Atrophy:



Diseases related to cerebral atrophy

Symptoms for Cerebral Atrophy

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Drugs & Therapeutics for Cerebral Atrophy

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Cerebral Atrophy

Search NIH Clinical Center for Cerebral Atrophy

Genetic Tests for Cerebral Atrophy

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Anatomical Context for Cerebral Atrophy

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33MalaCards
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MalaCards organs/tissues related to Cerebral Atrophy:

33
Brain, Testes, Temporal lobe, Kidney, Liver, Thyroid, Pineal

Animal Models for Cerebral Atrophy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cerebral Atrophy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.6GFAP, APOE, MAPT, CREB1, TREX1
2MP:00053787.3TREX1, CREB1, MAPT, RNASEH2B, APOE, GFAP
3MP:00053877.0GFAP, APOE, RNASEH2B, SAMHD1, MAPT, TREX1
4MP:00053846.4GFAP, APOE, RNASEH2B, SAMHD1, FH, MAPT
5MP:00107686.2TREX1, GFAP, APOE, RNASEH2B, RNASEH2C, SAMHD1

Publications for Cerebral Atrophy

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52PubMed
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Articles related to Cerebral Atrophy:

(show top 50)    (show all 371)
idTitleAuthorsYear
1
Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. (20576949)
2010
2
Cerebral atrophy, apolipoprotein E varepsilon4, and rate of decline in everyday function among patients with amnestic mild cognitive impairment. (20813341)
2010
3
Retinal vessel abnormalities are associated with elevated fasting insulin levels and cerebral atrophy in nondiabetic individuals. (19376581)
2009
4
Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. (19270764)
2009
5
Cerebral atrophy after traumatic white matter injury: correlation with acute neuroimaging and outcome. (19072588)
2008
6
Is intracranial atherosclerosis an independent risk factor for cerebral atrophy? A retrospective evaluation. (19102733)
2008
7
Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington's disease. (18831882)
2008
8
Determinants of cerebral atrophy rate at the time of diagnosis of multiple sclerosis. (17296834)
2007
9
Relationship between inflammatory lesions and cerebral atrophy in multiple sclerosis. (16505310)
2006
10
A 24-year follow-up of body mass index and cerebral atrophy. (15557505)
2004
11
Topography of cerebral atrophy in early Huntington's disease: a voxel based morphometric MRI study. (14742591)
2004
12
Cerebral atrophy after acute traumatic subdural or extradural hematomas in adults. (11904078)
2002
13
White matter T(1) relaxation time histograms and cerebral atrophy in multiple sclerosis. (11997065)
2002
14
Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. (12377138)
2002
15
Cerebral atrophy related to corticotherapy in systemic lupus erythematosus (SLE). (11529629)
2001
16
The prevalence of depression in relation to cerebral atrophy and cognitive performance in 70- and 74-year-old women in Gothenburg. The Women's Health Study. (11200959)
2001
17
Rates of global and regional cerebral atrophy in AD and frontotemporal dementia. (11723259)
2001
18
Primary antiphospholipid syndrome and cerebral atrophy: a rare association? (10372845)
1999
19
Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer's disease. (10382699)
1999
20
Parry-Romberg syndrome with ipsilateral cerebral atrophy of neonatal onset. (10651568)
1999
21
Apolipoprotein E in cerebrospinal fluid in 85-year-old subjects. Relation to dementia, apolipoprotein E polymorphism, cerebral atrophy, and white matter lesions. (9074395)
1997
22
Hemispheric cerebral atrophy after traumatic extra-axial hematoma in adults. (9414923)
1997
23
Progression of cerebral atrophy in hemodialysis patients: what about hypertension? (8773374)
1996
24
Progress in the CT evaluation of the cerebral atrophy in acute poisoning with carbon monoxide. (7644693)
1995
25
The relationship of pineal calcification to cerebral atrophy on CT scan in multiple sclerosis. (7960471)
1994
26
Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndrome. (8517682)
1993
27
Localized cerebral atrophy: an important cause of non-Alzheimer's dementia. (8242214)
1993
28
Cerebral atrophy in habitual cocaine abusers: a planimetric CT study. (1985292)
1991
29
Comparative assessment of the disorders of higher brain functions in various types of cerebral atrophy. (1758626)
1991
30
Widened subarachnoid space in pre-discharge cranial ultrasound: evidence of cerebral atrophy in immature infants? (2257986)
1990
31
Progressive dysphasic dementia with localized cerebral atrophy: report of an autopsy. (1703058)
1990
32
Intra- and interobserver variation in CT-evaluated cerebral atrophy. (2849155)
1988
33
Cerebral atrophy and neuropsychological correlates in schizophrenia. (3452986)
1987
34
Controlling for cerebral atrophy in positron emission tomography data. (2956273)
1987
35
Cerebral atrophy in younger persons: a comparative study between clinical examinations and computed tomography. (3621817)
1987
36
Automated measurements of cerebral atrophy in multiple sclerosis. (3329300)
1987
37
Rapid development of cerebral atrophy in systemic lupus erythematosus. (3730739)
1986
38
Cerebral atrophy and nephropathic cystinosis. (3707194)
1986
39
Cerebral atrophy in patients on long-term regular hemodialysis treatment. (3872759)
1985
40
Relation between central cerebral atrophy, memory defects and prolactin secretion. (7178373)
1982
41
CT-scan and EEG findings in professional pugilists: early detection of cerebral atrophy in young boxers. (7182434)
1982
42
Organic mental syndrome and confusional states in Parkinson's disease. Relationship to computerized tomographic signs of cerebral atrophy. (7236060)
1981
43
Cerebral atrophy in anorexia nervosa. (7365589)
1980
44
Differential effects of age and cerebral atrophy upon span of immediate recall and paired-associate learning in older patients suspected of dementia. (477343)
1979
45
Computed tomography scans of alcoholics: cerebral atrophy? (451571)
1979
46
Cerebral atrophy and cognitive impairment in chronic schizophrenia. (62915)
1976
47
Persistence of intraventricular air after pneumoencephalography: its failure to distinguish between cerebral atrophy and normal pressure hydrocephalus. (1226627)
1975
48
ANGIOGRAPHY IN LOCAL CORTICAL CEREBRAL ATROPHY. (14100393)
1963
49
Clinical aspects of cerebral atrophy revealed by encephalography. (13266111)
1955
50
Cerebral atrophy in psychiatric patients. (13207430)
1954

Variations for Cerebral Atrophy

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Expression for genes affiliated with Cerebral Atrophy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Atrophy

Search GEO for disease gene expression data for Cerebral Atrophy.

Pathways for genes affiliated with Cerebral Atrophy

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50PathCards, 55Reactome, 30KEGG, 53QIAGEN, 5Cell Signaling Technology
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Compounds for genes affiliated with Cerebral Atrophy

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 3BitterDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Cerebral Atrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1fluorochrome459.8RPS27A, MAPT
2quisqualate45 1110.7MAPT, CREB1
3gelfoam459.7GFAP, MAPT
4cysteamine45 24 1111.6RPS27A, APOE
5tacrine45 1110.5MAPT, APOE
6donepezil45 51 24 1112.4APOE, MAPT
7methamphetamine45 51 1111.4CREB1, RPS27A, GFAP
86-hydroxydopamine459.4CREB1, RPS27A, GFAP
9silver459.4MAPT, RPS27A, GFAP
10diisopropylfluorophosphate459.3MAPT, GFAP
11galantamine45 51 1111.3APOE, MAPT
12formaldehyde45 2410.3MAPT, RPS27A, GFAP
13thioflavine s459.2APOE, RPS27A, MAPT
14chloroquine45 3 51 29 1113.2MAPT, RPS27A, APOE
15gaba459.1GFAP, RPS27A, CREB1
16sodium dodecylsulfate459.1MAPT, RPS27A, APOE
17streptozotocin459.1GFAP, APOE, RPS27A
18isoproterenol45 1110.1GFAP, MAPT, CREB1
19valine459.0MAPT, RPS27A, APOE
20guanine45 24 1111.0CREB1, RPS27A, APOE
21spec-t458.9MAPT, APOE, GFAP
22retinoid458.9CREB1, RPS27A, APOE
23cyclosporin a45 29 6110.9MAPT, RPS27A, SEPSECS, APOE
24butyrate458.9GFAP, RPS27A, MAPT, CREB1
25glycogen45 249.8GFAP, RPS27A, MAPT, CREB1
264-hydroxynonenal45 249.7CREB1, MAPT, RPS27A, APOE
27lactacystin458.7APOE, RPS27A, MAPT, CREB1
28n acetylcysteine458.7APOE, RPS27A, MAPT, CREB1
29actinomycin d458.6APOE, RPS27A, MAPT, CREB1
30formate458.6MAPT, RPS27A, APOE, GFAP
31paraffin458.5GFAP, APOE, RPS27A, MAPT
32lactate458.5GFAP, FH, RPS27A, MAPT, CREB1
33h2o2458.5CREB1, MAPT, RPS27A, APOE
34threonine458.5CREB1, MAPT, RPS27A, GFAP
35kainate45 299.4CREB1, MAPT, APOE, GFAP
36vegf458.2GFAP, APOE, RPS27A, CREB1
37creatinine458.2GFAP, APOE, FH, RPS27A, MAPT
38aspartate458.2GFAP, APOE, FH, RPS27A, MAPT
39zinc45 249.2GFAP, RPS27A, MAPT, CREB1
40nmda45 299.1GFAP, APOE, RPS27A, MAPT, CREB1
41acetylcholine45 51 29 24 1112.1CREB1, MAPT, RPS27A, APOE, GFAP
42glutamine458.1GFAP, APOE, RPS27A, MAPT, CREB1
43dopamine45 29 24 1111.1CREB1, MAPT, RPS27A, APOE, GFAP
44arginine458.1GFAP, APOE, RPS27A, MAPT
45cycloheximide458.1GFAP, APOE, RPS27A, MAPT, CREB1
46testosterone45 61 24 1111.0GFAP, APOE, RPS27A, MAPT, CREB1
47glutamate458.0GFAP, APOE, RPS27A, MAPT, CREB1
48estrogen458.0GFAP, APOE, RPS27A, MAPT, CREB1
49cysteine458.0GFAP, APOE, RPS27A, MAPT, CREB1
50serine457.7GFAP, APOE, SEPSECS, RPS27A, MAPT, CREB1

GO Terms for genes affiliated with Cerebral Atrophy

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16Gene Ontology
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Cellular components related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribonuclease H2 complexGO:0322999.5RNASEH2C, RNASEH2A, RNASEH2B

Biological processes related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon productionGO:0324799.9TREX1, RPS27A
2mismatch repairGO:0062989.8RNASEH2A, TREX1
3stress-activated MAPK cascadeGO:0514039.6CREB1, RPS27A
4RNA catabolic processGO:0064019.6RNASEH2C, RNASEH2A, RNASEH2B
5positive regulation of axon extensionGO:0457739.1MAPT, APOE
6innate immune responseGO:0450878.6TREX1, CREB1, RPS27A, SAMHD1

Molecular functions related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA-DNA hybrid ribonuclease activityGO:0045239.7RNASEH2A, RNASEH2B
2lipoprotein particle bindingGO:0718138.8MAPT, APOE

Products for genes affiliated with Cerebral Atrophy

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Sources for Cerebral Atrophy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet