MCID: CRB088
MIFTS: 46

Cerebral Atrophy malady

Summaries for Cerebral Atrophy

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means loss of cells. In brain tissue, atrophy describes a loss of neurons and the connections between them. Atrophy can be generalized, which means that all of the brain has shrunk; or it can be focal, affecting only a limited area of the brain and resulting in a decrease of the functions that area of the brain controls. If the cerebral hemispheres (the two lobes of the brain that form the cerebrum) are affected, conscious thought and voluntary processes may be impaired.

MalaCards: Cerebral Atrophy is related to progressive supranuclear palsy and parkinson's disease. An important gene associated with Cerebral Atrophy is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways are Regulation of innate immune responses to cytosolic DNA and Lagging Strand Synthesis. The compounds cycloheximide and tacrine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and cerebellum, and related mouse phenotypes are renal/urinary system and muscle.

Wikipedia:64 Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any... more...

Aliases & Classifications for Cerebral Atrophy

Sources:
44NINDS, 61UMLS
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Aliases & Descriptions:

cerebral atrophy 44 61


Related Diseases for Cerebral Atrophy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cerebral Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1progressive supranuclear palsy30.2MAPT, APOE, RPS27A
2parkinson's disease30.2MAPT, APOE, RPS27A
3aphasia30.1MAPT
4frontotemporal dementia30.0MAPT, APOE, RPS27A
5huntington's disease30.0RPS27A, CREB1, MAPT
6memory impairment30.0APOE, CREB1, MAPT
7mental retardation30.0CLN8, MAPT, CREB1, PPT1
8primary progressive aphasia29.8RPS27A, MAPT
9vascular dementia29.8RPS27A, APOE, MAPT
10aicardi-goutieres syndrome29.8SAMHD1, TREX1, RNASEH2C, RNASEH2B, RNASEH2A
11hemorrhage, intracerebral29.8APOE, RPS27A
12keratosis follicularis dwarfism and cerebral atrophy10.4
13brain injury10.3
14normal pressure hydrocephalus10.3
15alzheimer's disease10.3
16anorexia nervosa10.3
17n syndrome10.3
18traumatic brain injury10.3
19systemic lupus erythematosus10.2
20cerebral atherosclerosis10.1
21atherosclerosis10.1
22head injury10.1
23progressive cerebello-cerebral atrophy10.1
24intellectual deficit, x-linked - dysmorphism - cerebral atrophy10.1
25relapsing-remitting multiple sclerosis10.1
26acquired immunodeficiency syndrome10.1
27secondary progressive multiple sclerosis10.1
28uremia10.1
29vascular disease10.1
30autosomal recessive cerebral atrophy10.1
31hepatitis10.0SEPSECS
32chilblain lupus10.0TREX1
33scrapie10.0MAPT
34brain ischemia10.0MAPT
35neuronal intranuclear inclusion disease10.0RPS27A
36hydrocephalus10.0MAPT
37semantic dementia10.0MAPT, RPS27A
38myositis10.0MAPT, RPS27A
39visual epilepsy10.0TPP1, CLN6
40inclusion body myositis10.0MAPT, RPS27A
41motor neuron disease10.0MAPT, RPS27A
42prion disease10.0GFAP
43encephalitis10.0GFAP
44lewy body dementia10.0APOE, MAPT
45cerebral amyloid angiopathy10.0APOE, MAPT
46brain disease10.0FH, MAPT, CLN5
47lupus erythematosus10.0TREX1
48alzheimer disease type 210.0MAPT, APOE
49fibrous histiocytoma10.0CREB1
50creutzfeldt-jakob syndrome10.0MAPT, APOE, RPS27A

Graphical network of the top 20 diseases related to Cerebral Atrophy:



Diseases related to cerebral atrophy

Clinical Features for Cerebral Atrophy

Drugs & Therapeutics for Cerebral Atrophy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cerebral Atrophy

Drug clinical trials:

Search ClinicalTrials for Cerebral Atrophy

Search NIH Clinical Center for Cerebral Atrophy

Search CenterWatch for Cerebral Atrophy

Genetic Tests for Cerebral Atrophy

Anatomical Context for Cerebral Atrophy

Sources:
33MalaCards
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MalaCards organs/tissues related to Cerebral Atrophy:

33
Brain, Cortex, Cerebellum, Retina, Heart, Kidney, Liver, Thyroid, T cells, B lymphoblasts, B cells, Temporal lobe, Thalamus, Pineal

Animal Models for Cerebral Atrophy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cerebral Atrophy

Sources:
51PubMed
See all sources

Articles related to Cerebral Atrophy:

(show top 50)    (show all 417)
idTitleAuthorsYear
1
Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease. (21596458)
2012
2
Rapid progressive cerebral atrophy in systemic lupus erythematosus. (22134797)
2011
3
Marked cerebral atrophy is correlated with kidney dysfunction in nondisabled adults. (20944639)
2010
4
Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. (19270764)
2009
5
Foetal cerebral hemispheric atrophy and porencephaly after intrauterine exposure to maternal warfarin for mechanical prosthetic heart valve. (18186154)
2008
6
Day-of-injury computerized tomography, rehabilitation status, and development of cerebral atrophy in persons with traumatic brain injury. (16998426)
2006
7
Cerebral autoregulation is preserved in multiple system atrophy: A transcranial Doppler study. (17029266)
2006
8
Cerebral atrophy measurements using Jacobian integration: comparison with the boundary shift integral. (16675272)
2006
9
Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy. (15843423)
2005
10
Distribution of cerebral atrophy assessed by magnetic resonance imaging reflects patterns of neuropsychological deficits in Alzheimer's dementia. (15135882)
2004
11
The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementia. (14644147)
2004
12
Progressive cerebral atrophy in multiple system atrophy. (11897242)
2002
13
Partial cerebral atrophy (1909) [classical article]. (11721867)
2001
14
Generalised cerebral atrophy following temporal lobectomy for intractable epilepsy associated with mesial temporal sclerosis. (10745135)
2000
15
Primary antiphospholipid syndrome and cerebral atrophy: a rare association? (10372845)
1999
16
Inter- and intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts. (8864706)
1996
17
Amylaceous (polyglucosan) bodies in familial cerebral atrophy of early onset. (8745390)
1996
18
Correlations of leuko-araiosis with cerebral atrophy and perfusion in elderly normal subjects and demented patients. (8437007)
1993
19
Cerebral cortical pathology of sporadic olivopontocerebellar atrophy. (8251013)
1993
20
Cocaine and cerebral atrophy. (1741838)
1991
21
Cerebral atrophy in bulimia. (2720004)
1989
22
Severe cerebral atrophy in progressive supranuclear palsy: a case report. (2776386)
1989
23
Pathogenesis of cerebral atrophy in uraemia. State of the art. (3288891)
1988
24
Controlling for cerebral atrophy in positron emission tomography data. (2956273)
1987
25
Automated measurements of cerebral atrophy in multiple sclerosis. (3329300)
1987
26
Rapid development of cerebral atrophy in systemic lupus erythematosus. (3730739)
1986
27
Diagnosis of cerebral atrophy in infants by near-field cranial sonography. (3524196)
1986
28
N-acetylaspartic aciduria in a child with a progressive cerebral atrophy. (3769199)
1986
29
The severity of alcoholism and its relation to intellectual impairment and cerebral atrophy. (3457600)
1986
30
A comparison of cerebral atrophy in CT scan findings among alcoholic groups. (6582765)
1983
31
Cerebral atrophy in torture victims. (6835290)
1983
32
Cerebral atrophy in systemic lupus erythematosus: steroid- or disease-induced phenomenon? (6800237)
1982
33
Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease. (7194430)
1981
34
Cerebral atrophy in anorexia nervosa. (7365589)
1980
35
Apparent cerebral atrophy in patients on treatment with steroids. (6250932)
1980
36
Schizophrenia and cerebral atrophy. (6104161)
1980
37
Bicaudate index in computerized tomography of Huntington disease and cerebral atrophy. (152416)
1978
38
Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans. (653357)
1978
39
Cerebral atrophy and cognitive impairment in chronic schizophrenia. (63778)
1976
40
Cerebrospinal fluid uric acid levels in cerebral atrophy occurring in psychiatric and neurologic patients. (4850944)
1974
41
Measurement of intrathecal I131-albumin transport to plasma. Inability to distinguish cerebral atrophy from communicating hydrocephalus. (4499965)
1974
42
Cerebral atrophy in young cannabis smokers. (4143590)
1971
43
Radiographic findings in hypothalamic acceleration of growth associated with cerebral atrophy and mental retardation (cerebral gigantism). (4289663)
1967
44
ANGIOGRAPHY IN LOCAL CORTICAL CEREBRAL ATROPHY. (14100393)
1963
45
Familial occurrence of neural muscle atrophy (Tooth-Marie-Charcot) combined with cerebral atrophy and parkinsonism. (14475031)
1961
46
Subacute spongiform encephalopathy--a subacute form of encephalopathy attributable to vascular dysfunction (spongiform cerebral atrophy). (13728615)
1960
47
Clinical aspects of cerebral atrophy revealed by encephalography. (13266111)
1955
48
Cerebral atrophy; clinical manifestations in adults. (13150199)
1954
49
Shift of writing function to minor hemisphere at the age of seventy-two years; report of case with advanced left cerebral atrophy. (12997924)
1952
50
Reversible cerebral atrophy. (13085010)
1951

Genetic Variations for Cerebral Atrophy

Expression for genes affiliated with Cerebral Atrophy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Atrophy

Search GEO for disease gene expression data for Cerebral Atrophy.

Pathways for genes affiliated with Cerebral Atrophy

Sources:
54Reactome, 30KEGG, 4Cell Signaling Technology
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Pathways related to Cerebral Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TREX1, RPS27A
2
Hide members
9.8RNASEH2C, RNASEH2B, RNASEH2A
39.2TPP1, CLN5, CLN3, PPT1
48.6GFAP, MAPT, CREB1, APOE

Compounds for genes affiliated with Cerebral Atrophy

Sources:
45Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Cerebral Atrophy according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5MAPT
2tacrine45 1111.0APOE, MAPT
3donepezil45 11 2411.9MAPT, APOE
4thioflavine s459.9MAPT, APOE, RPS27A
5gelfoam459.9GFAP, MAPT
6cysteamine45 11 2411.7APOE, RPS27A
7chloroquine45 2 50 29 1113.7MAPT, APOE, RPS27A
8quisqualate45 1110.7CREB1, MAPT
9sodium dodecylsulfate459.6RPS27A, APOE, MAPT
10palmitate459.6DNAJC5, PPT1, APOE, RPS27A
11silver459.6RPS27A, MAPT, GFAP
12mannose 6-phosphate45 2410.5TPP1, CLN3, PPT1
13spec-t459.5APOE, MAPT, GFAP
14streptozotocin459.5GFAP, APOE, RPS27A
15methamphetamine45 50 1111.4GFAP, CREB1, RPS27A
166-hydroxydopamine459.4RPS27A, CREB1, GFAP
174-hydroxynonenal45 2410.4RPS27A, APOE, CREB1, MAPT
18lactacystin459.3MAPT, CREB1, APOE, RPS27A
19formate459.3GFAP, MAPT, APOE, RPS27A
20nmda45 2910.2RPS27A, APOE, MAPT, GFAP
21n acetylcysteine459.2MAPT, CREB1, APOE, RPS27A
22butyrate459.0GFAP, MAPT, CREB1, RPS27A
23kainate45 2910.0APOE, CREB1, MAPT, GFAP
24creatinine458.8GFAP, MAPT, APOE, FH, RPS27A
25lactate458.8GFAP, MAPT, CREB1, FH, RPS27A
26acetylcholine45 50 29 11 2412.7RPS27A, APOE, CREB1, MAPT, GFAP
27glycogen45 249.7RPS27A, CREB1, MAPT, GFAP
28glutamine458.7RPS27A, APOE, CREB1, MAPT, GFAP
29dopamine45 29 11 2411.7RPS27A, APOE, CREB1, MAPT, GFAP
30actinomycin d458.6MAPT, CREB1, APOE, RPS27A
31aspartate458.6RPS27A, FH, APOE, MAPT, GFAP, TPP1
32testosterone45 60 11 2411.5GFAP, MAPT, CREB1, APOE, RPS27A
33glutamate458.3RPS27A, APOE, CREB1, MAPT, CLN3, GFAP
34cysteine458.1RPS27A, APOE, PPT1, CREB1, MAPT, DNAJC5
35atp45 299.1RPS27A, FH, PPT1, CREB1, CLN3, GFAP
36lipid458.0APOE, PPT1, CREB1, CLN8, CLN6, CLN3
37serine457.5RPS27A, APOE, PPT1, CREB1, MAPT, CLN3

GO Terms for genes affiliated with Cerebral Atrophy

Sources:
16Gene Ontology
See all sources

Cellular components related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribonuclease H2 complexGO:0322999.7RNASEH2A, RNASEH2B, RNASEH2C
2synaptic vesicleGO:0080219.6CLN3, DNAJC5, PPT1
3lysosomeGO:0057648.9PPT1, CLN3, CLN5, TPP1

Biological processes related to Cerebral Atrophy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1RNA catabolic processGO:00640110.1RNASEH2C, RNASEH2B, RNASEH2A
2cellular protein catabolic processGO:04425710.0CLN8, PPT1
3regulation of type I interferon productionGO:03247910.0RPS27A, TREX1
4negative regulation of proteolysisGO:0458619.9CLN3, CLN8
5associative learningGO:0083069.8PPT1, CLN8, CLN3
6regulation of cell sizeGO:0083619.8CLN8, CREB1
7ceramide metabolic processGO:0066729.8CLN3, CLN8
8lysosome organizationGO:0070409.8CLN8, CLN3, TPP1
9neuromuscular process controlling balanceGO:0508859.8TPP1, CLN3, CLN8
10cholesterol metabolic processGO:0082039.7APOE, CLN8, CLN6
11visual perceptionGO:0076019.7CLN5, CLN6, CLN8, PPT1
12lysosomal lumen acidificationGO:0070429.6PPT1, CLN6, CLN3, CLN5
13receptor-mediated endocytosisGO:0068989.5APOE, PPT1, CLN3
14positive regulation of axon extensionGO:0457739.5MAPT, APOE
15negative regulation of neuron apoptotic processGO:0435249.3CLN3, DNAJC5, PPT1, APOE
16protein catabolic processGO:0301639.1TPP1, PPT1, CLN8, CLN6, CLN3, CLN5
17cell deathGO:0082198.5APOE, TREX1, DNAJC5, CLN8, CLN6, CLN3

Molecular functions related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.8MAPT, APOE

Products for genes affiliated with Cerebral Atrophy

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Sources for Cerebral Atrophy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet