MCID: CRB088
MIFTS: 44

Cerebral Atrophy malady

Summaries for Cerebral Atrophy

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45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means loss of cells. In brain tissue, atrophy describes a loss of neurons and the connections between them. Atrophy can be generalized, which means that all of the brain has shrunk; or it can be focal, affecting only a limited area of the brain and resulting in a decrease of the functions that area of the brain controls. If the cerebral hemispheres (the two lobes of the brain that form the cerebrum) are affected, conscious thought and voluntary processes may be impaired.

MalaCards: Cerebral Atrophy is related to dementia and parkinson's disease. An important gene associated with Cerebral Atrophy is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways are Signaling by NOTCH2 and Circadian Clock. The compounds fluorochrome and quisqualate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related mouse phenotypes are muscle and growth/size/body.

Wikipedia:66 Cerebral atrophy is a common feature of many of the diseases that affect the brain.Atrophy of any tissue... more...

Aliases & Classifications for Cerebral Atrophy

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45NINDS, 63UMLS
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Aliases & Descriptions:

cerebral atrophy 45 63


Related Diseases for Cerebral Atrophy

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18GeneCards, 19GeneDecks
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Diseases related to Cerebral Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.9GFAP, APOE, RPS27A, MAPT
2parkinson's disease30.5MAPT, RPS27A, APOE
3alzheimer's disease30.5GFAP, APOE, RPS27A, MAPT, CREB1
4huntington's disease30.3RPS27A, MAPT, CREB1
5progressive supranuclear palsy30.2MAPT, RPS27A, APOE
6multiple system atrophy30.1GFAP, RPS27A, MAPT
7frontotemporal dementia30.1APOE, RPS27A, MAPT
8primary progressive aphasia30.0RPS27A, MAPT
9tauopathy29.9RPS27A, MAPT
10motor neuron disease29.9MAPT, RPS27A
11amyotrophic lateral sclerosis29.9GFAP, RPS27A, MAPT
12vascular dementia29.8APOE, RPS27A, MAPT
13creutzfeldt-jakob disease29.8MAPT, RPS27A, APOE
14aicardi-goutieres syndrome29.8TREX1, SAMHD1, RNASEH2C, RNASEH2A, RNASEH2B
15memory impairment29.8CREB1, MAPT, APOE
16cerebrovascular disease29.8CREB1, MAPT, APOE
17cerebritis11.2
18multiple sclerosis10.6
19hydrocephalus10.5
20schizophrenia10.4
21keratosis follicularis dwarfism and cerebral atrophy10.4
22normal pressure hydrocephalus10.3
23brain injury10.3
24anorexia nervosa10.3
25systemic lupus erythematosus10.2
26hypertension10.2
27lupus erythematosus10.2
28retinitis10.2
29traumatic brain injury10.2
30atherosclerosis10.2
31head injury10.2
32x-linked intellectual disability - dysmorphism - cerebral atrophy10.2
33chilblain lupus10.1TREX1
34neuronal intranuclear inclusion disease10.1RPS27A
35acquired immunodeficiency syndrome10.1
36secondary progressive multiple sclerosis10.1
37aphasia10.1
38neuropathy10.1
39mental retardation10.1
40autosomal recessive cerebral atrophy10.1
41semantic dementia10.1RPS27A, MAPT
42inclusion body myositis10.1MAPT, RPS27A
43alexander disease10.0GFAP, RPS27A
44dentatorubral-pallidoluysian atrophy10.0RPS27A, CREB1
45alcohol abuse10.0RPS27A, CREB1
46spinocerebellar ataxia10.0MAPT, RPS27A
47movement disease10.0MAPT, RPS27A
48age related macular degeneration10.0APOE
49binswanger's disease10.0GFAP, MAPT
50hemorrhage, intracerebral10.0APOE, RPS27A

Graphical network of the top 20 diseases related to Cerebral Atrophy:



Diseases related to cerebral atrophy

Symptoms for Cerebral Atrophy

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Drugs & Therapeutics for Cerebral Atrophy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Cerebral Atrophy

Drug clinical trials:

Search ClinicalTrials for Cerebral Atrophy

Search NIH Clinical Center for Cerebral Atrophy

Search CenterWatch for Cerebral Atrophy

Genetic Tests for Cerebral Atrophy

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Anatomical Context for Cerebral Atrophy

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34MalaCards
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MalaCards organs/tissues related to Cerebral Atrophy:

34
Brain, Testes, Temporal lobe, Kidney, Liver, Thyroid, Pineal

Animal Models for Cerebral Atrophy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Cerebral Atrophy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.6GFAP, APOE, MAPT, CREB1, TREX1
2MP:00053787.3TREX1, CREB1, MAPT, RNASEH2B, APOE, GFAP
3MP:00053877.0GFAP, APOE, RNASEH2B, SAMHD1, MAPT, TREX1
4MP:00053846.4GFAP, APOE, RNASEH2B, SAMHD1, FH, MAPT
5MP:00107686.2TREX1, GFAP, APOE, RNASEH2B, RNASEH2C, SAMHD1

Publications for Cerebral Atrophy

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53PubMed
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Articles related to Cerebral Atrophy:

(show top 50)    (show all 371)
idTitleAuthorsYear
1
Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. (20576949)
2010
2
Cerebral atrophy, apolipoprotein E varepsilon4, and rate of decline in everyday function among patients with amnestic mild cognitive impairment. (20813341)
2010
3
Retinal vessel abnormalities are associated with elevated fasting insulin levels and cerebral atrophy in nondiabetic individuals. (19376581)
2009
4
Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. (19270764)
2009
5
Cerebral atrophy after traumatic white matter injury: correlation with acute neuroimaging and outcome. (19072588)
2008
6
Is intracranial atherosclerosis an independent risk factor for cerebral atrophy? A retrospective evaluation. (19102733)
2008
7
Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington's disease. (18831882)
2008
8
Determinants of cerebral atrophy rate at the time of diagnosis of multiple sclerosis. (17296834)
2007
9
Relationship between inflammatory lesions and cerebral atrophy in multiple sclerosis. (16505310)
2006
10
A 24-year follow-up of body mass index and cerebral atrophy. (15557505)
2004
11
Topography of cerebral atrophy in early Huntington's disease: a voxel based morphometric MRI study. (14742591)
2004
12
Cerebral atrophy after acute traumatic subdural or extradural hematomas in adults. (11904078)
2002
13
White matter T(1) relaxation time histograms and cerebral atrophy in multiple sclerosis. (11997065)
2002
14
Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. (12377138)
2002
15
Cerebral atrophy related to corticotherapy in systemic lupus erythematosus (SLE). (11529629)
2001
16
The prevalence of depression in relation to cerebral atrophy and cognitive performance in 70- and 74-year-old women in Gothenburg. The Women's Health Study. (11200959)
2001
17
Rates of global and regional cerebral atrophy in AD and frontotemporal dementia. (11723259)
2001
18
Primary antiphospholipid syndrome and cerebral atrophy: a rare association? (10372845)
1999
19
Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer's disease. (10382699)
1999
20
Parry-Romberg syndrome with ipsilateral cerebral atrophy of neonatal onset. (10651568)
1999
21
Apolipoprotein E in cerebrospinal fluid in 85-year-old subjects. Relation to dementia, apolipoprotein E polymorphism, cerebral atrophy, and white matter lesions. (9074395)
1997
22
Hemispheric cerebral atrophy after traumatic extra-axial hematoma in adults. (9414923)
1997
23
Progression of cerebral atrophy in hemodialysis patients: what about hypertension? (8773374)
1996
24
Progress in the CT evaluation of the cerebral atrophy in acute poisoning with carbon monoxide. (7644693)
1995
25
The relationship of pineal calcification to cerebral atrophy on CT scan in multiple sclerosis. (7960471)
1994
26
Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndrome. (8517682)
1993
27
Localized cerebral atrophy: an important cause of non-Alzheimer's dementia. (8242214)
1993
28
Cerebral atrophy in habitual cocaine abusers: a planimetric CT study. (1985292)
1991
29
Comparative assessment of the disorders of higher brain functions in various types of cerebral atrophy. (1758626)
1991
30
Widened subarachnoid space in pre-discharge cranial ultrasound: evidence of cerebral atrophy in immature infants? (2257986)
1990
31
Progressive dysphasic dementia with localized cerebral atrophy: report of an autopsy. (1703058)
1990
32
Intra- and interobserver variation in CT-evaluated cerebral atrophy. (2849155)
1988
33
Cerebral atrophy and neuropsychological correlates in schizophrenia. (3452986)
1987
34
Controlling for cerebral atrophy in positron emission tomography data. (2956273)
1987
35
Cerebral atrophy in younger persons: a comparative study between clinical examinations and computed tomography. (3621817)
1987
36
Automated measurements of cerebral atrophy in multiple sclerosis. (3329300)
1987
37
Rapid development of cerebral atrophy in systemic lupus erythematosus. (3730739)
1986
38
Cerebral atrophy and nephropathic cystinosis. (3707194)
1986
39
Cerebral atrophy in patients on long-term regular hemodialysis treatment. (3872759)
1985
40
Relation between central cerebral atrophy, memory defects and prolactin secretion. (7178373)
1982
41
CT-scan and EEG findings in professional pugilists: early detection of cerebral atrophy in young boxers. (7182434)
1982
42
Organic mental syndrome and confusional states in Parkinson's disease. Relationship to computerized tomographic signs of cerebral atrophy. (7236060)
1981
43
Cerebral atrophy in anorexia nervosa. (7365589)
1980
44
Differential effects of age and cerebral atrophy upon span of immediate recall and paired-associate learning in older patients suspected of dementia. (477343)
1979
45
Computed tomography scans of alcoholics: cerebral atrophy? (451571)
1979
46
Cerebral atrophy and cognitive impairment in chronic schizophrenia. (62915)
1976
47
Persistence of intraventricular air after pneumoencephalography: its failure to distinguish between cerebral atrophy and normal pressure hydrocephalus. (1226627)
1975
48
ANGIOGRAPHY IN LOCAL CORTICAL CEREBRAL ATROPHY. (14100393)
1963
49
Clinical aspects of cerebral atrophy revealed by encephalography. (13266111)
1955
50
Cerebral atrophy in psychiatric patients. (13207430)
1954

Variations for Cerebral Atrophy

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Expression for genes affiliated with Cerebral Atrophy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Atrophy

Search GEO for disease gene expression data for Cerebral Atrophy.

Pathways for genes affiliated with Cerebral Atrophy

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Sources:
51PathCards, 56Reactome, 31KEGG, 54QIAGEN, 5Cell Signaling Technology
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Compounds for genes affiliated with Cerebral Atrophy

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46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 3BitterDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Cerebral Atrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1fluorochrome469.8RPS27A, MAPT
2quisqualate46 1210.7MAPT, CREB1
3gelfoam469.7GFAP, MAPT
4cysteamine46 25 1211.6RPS27A, APOE
5tacrine46 1210.5MAPT, APOE
6donepezil46 52 25 1212.4APOE, MAPT
7methamphetamine46 52 1211.4CREB1, RPS27A, GFAP
86-hydroxydopamine469.4CREB1, RPS27A, GFAP
9silver469.4MAPT, RPS27A, GFAP
10diisopropylfluorophosphate469.3MAPT, GFAP
11galantamine46 52 1211.3APOE, MAPT
12formaldehyde46 2510.3MAPT, RPS27A, GFAP
13thioflavine s469.2APOE, RPS27A, MAPT
14chloroquine46 3 52 30 1213.2MAPT, RPS27A, APOE
15gaba469.1GFAP, RPS27A, CREB1
16sodium dodecylsulfate469.1MAPT, RPS27A, APOE
17streptozotocin469.1GFAP, APOE, RPS27A
18isoproterenol46 1210.1GFAP, MAPT, CREB1
19valine469.0MAPT, RPS27A, APOE
20guanine46 25 1211.0CREB1, RPS27A, APOE
21spec-t468.9MAPT, APOE, GFAP
22retinoid468.9CREB1, RPS27A, APOE
23cyclosporin a46 30 6210.9MAPT, RPS27A, SEPSECS, APOE
24butyrate468.9GFAP, RPS27A, MAPT, CREB1
25glycogen46 259.8GFAP, RPS27A, MAPT, CREB1
264-hydroxynonenal46 259.7CREB1, MAPT, RPS27A, APOE
27lactacystin468.7APOE, RPS27A, MAPT, CREB1
28n acetylcysteine468.7APOE, RPS27A, MAPT, CREB1
29actinomycin d468.6APOE, RPS27A, MAPT, CREB1
30formate468.6MAPT, RPS27A, APOE, GFAP
31paraffin468.5GFAP, APOE, RPS27A, MAPT
32lactate468.5GFAP, FH, RPS27A, MAPT, CREB1
33h2o2468.5CREB1, MAPT, RPS27A, APOE
34threonine468.5CREB1, MAPT, RPS27A, GFAP
35kainate46 309.4CREB1, MAPT, APOE, GFAP
36vegf468.2GFAP, APOE, RPS27A, CREB1
37creatinine468.2GFAP, APOE, FH, RPS27A, MAPT
38aspartate468.2GFAP, APOE, FH, RPS27A, MAPT
39zinc46 259.2GFAP, RPS27A, MAPT, CREB1
40nmda46 309.1GFAP, APOE, RPS27A, MAPT, CREB1
41acetylcholine46 52 30 25 1212.1CREB1, MAPT, RPS27A, APOE, GFAP
42glutamine468.1GFAP, APOE, RPS27A, MAPT, CREB1
43dopamine46 30 25 1211.1CREB1, MAPT, RPS27A, APOE, GFAP
44arginine468.1GFAP, APOE, RPS27A, MAPT
45cycloheximide468.1GFAP, APOE, RPS27A, MAPT, CREB1
46testosterone46 62 25 1211.0GFAP, APOE, RPS27A, MAPT, CREB1
47glutamate468.0GFAP, APOE, RPS27A, MAPT, CREB1
48estrogen468.0GFAP, APOE, RPS27A, MAPT, CREB1
49cysteine468.0GFAP, APOE, RPS27A, MAPT, CREB1
50serine467.7GFAP, APOE, SEPSECS, RPS27A, MAPT, CREB1

GO Terms for genes affiliated with Cerebral Atrophy

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17Gene Ontology
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Cellular components related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribonuclease H2 complexGO:0322999.5RNASEH2C, RNASEH2A, RNASEH2B

Biological processes related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon productionGO:0324799.9TREX1, RPS27A
2mismatch repairGO:0062989.8RNASEH2A, TREX1
3stress-activated MAPK cascadeGO:0514039.6CREB1, RPS27A
4RNA catabolic processGO:0064019.6RNASEH2C, RNASEH2A, RNASEH2B
5positive regulation of axon extensionGO:0457739.1MAPT, APOE
6innate immune responseGO:0450878.6TREX1, CREB1, RPS27A, SAMHD1

Molecular functions related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA-DNA hybrid ribonuclease activityGO:0045239.7RNASEH2A, RNASEH2B
2lipoprotein particle bindingGO:0718138.8MAPT, APOE

Products for genes affiliated with Cerebral Atrophy

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  • Antibodies
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Sources for Cerebral Atrophy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet