MCID: CRB088
MIFTS: 40

Cerebral Atrophy malady

Neuronal diseases, Rare diseases categories

Aliases & Classifications for Cerebral Atrophy

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Cerebral Atrophy, Aliases & Descriptions:

Name: Cerebral Atrophy 42 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Summaries for Cerebral Atrophy

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NINDS:42 Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means loss of cells. In brain tissue, atrophy describes a loss of neurons and the connections between them. Atrophy can be generalized, which means that all of the brain has shrunk; or it can be focal, affecting only a limited area of the brain and resulting in a decrease of the functions that area of the brain controls. If the cerebral hemispheres (the two lobes of the brain that form the cerebrum) are affected, conscious thought and voluntary processes may be impaired.

MalaCards based summary: Cerebral Atrophy is related to dementia and tauopathy. An important gene associated with Cerebral Atrophy is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways are Signaling by NOTCH2 and Circadian Clock. The compounds fluorochrome and quisqualate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related mouse phenotypes are muscle and growth/size/body.

Wikipedia:63 Cerebral atrophy is a common feature of many of the diseases that affect the brain.Atrophy of any tissue... more...

Related Diseases for Cerebral Atrophy

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Diseases in the Cerebral Atrophy family:

Autosomal Recessive Cerebral Atrophy

Diseases related to Cerebral Atrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.0APOE, MAPT
2tauopathy30.2RPS27A, MAPT
3multiple system atrophy30.1GFAP, RPS27A, MAPT
4motor neuron disease29.9MAPT, RPS27A
5huntington disease29.9RPS27A, MAPT, CREB1
6vascular dementia29.7APOE, RPS27A, MAPT
7creutzfeldt-jakob disease29.7MAPT, RPS27A, APOE
8aicardi-goutieres syndrome29.7TREX1, SAMHD1, RNASEH2C, RNASEH2A, RNASEH2B
9alzheimer disease29.4GFAP, APOE, RPS27A, MAPT, CREB1
10cerebritis11.2
11hydrocephalus10.5
12chilblain lupus10.5TREX1
13schizophrenia10.5
14neuronal intranuclear inclusion disease10.4RPS27A
15keratosis follicularis dwarfism and cerebral atrophy10.4
16brain injury10.3
17normal pressure hydrocephalus10.3
18anorexia nervosa10.3
19traumatic brain injury10.3
20retinitis10.3
21semantic dementia10.3RPS27A, MAPT
22frontotemporal lobar degeneration with ubiquitin-positive inclusions10.2RPS27A, MAPT
23inclusion body myositis10.2MAPT, RPS27A
24systemic lupus erythematosus10.2
25lupus erythematosus10.2
26alexander disease10.2GFAP, RPS27A
27dentatorubro-pallidoluysian atrophy10.2RPS27A, CREB1
28alcohol abuse10.2RPS27A, CREB1
29spinocerebellar ataxia10.2MAPT, RPS27A
30movement disease10.2MAPT, RPS27A
31macular degeneration, age-related, 110.2APOE
32atherosclerosis10.2
33head injury10.2
34x-linked intellectual disability - dysmorphism - cerebral atrophy10.2
35autosomal recessive cerebral atrophy10.2
36hypotonia-cerebral atrophy-hyperglycinemia syndrome10.2
37congenital microcephaly-severe encephalopathy-progressive cerebral atrophy syndrome10.2
38binswanger's disease10.1GFAP, MAPT
39hemorrhage, intracerebral10.1APOE, RPS27A
40myositis10.1MAPT, RPS27A
41aicardi-goutieres syndrome 710.1
42epileptic encephalopathy, early infantile, 1710.1
43aicardi-goutieres syndrome 1, dominant and recessive10.1
44pontocerebellar hypoplasia type 2d10.1
45diabetic encephalopathy10.1
46acquired immunodeficiency syndrome10.1
47secondary progressive multiple sclerosis10.1
48aphasia10.1
49neuropathy10.1
50uremia10.1

Graphical network of the top 20 diseases related to Cerebral Atrophy:



Diseases related to cerebral atrophy

Symptoms for Cerebral Atrophy

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Drugs & Therapeutics for Cerebral Atrophy

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Drug clinical trials:

Search ClinicalTrials for Cerebral Atrophy

Search NIH Clinical Center for Cerebral Atrophy

Genetic Tests for Cerebral Atrophy

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Anatomical Context for Cerebral Atrophy

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MalaCards organs/tissues related to Cerebral Atrophy:

31
Brain, Testes, Temporal lobe, Kidney, Liver, Thyroid, Pineal

Animal Models for Cerebral Atrophy or affiliated genes

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MGI Mouse Phenotypes related to Cerebral Atrophy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.6GFAP, APOE, MAPT, CREB1, TREX1
2MP:00053787.3TREX1, CREB1, MAPT, RNASEH2B, APOE, GFAP
3MP:00053877.0GFAP, APOE, RNASEH2B, SAMHD1, MAPT, TREX1
4MP:00053846.4GFAP, APOE, RNASEH2B, SAMHD1, FH, MAPT
5MP:00107686.2TREX1, GFAP, APOE, RNASEH2B, RNASEH2C, SAMHD1

Publications for Cerebral Atrophy

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Articles related to Cerebral Atrophy:

(show top 50)    (show all 386)
idTitleAuthorsYear
1
Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. (20576949)
2010
2
Cerebral atrophy, apolipoprotein E varepsilon4, and rate of decline in everyday function among patients with amnestic mild cognitive impairment. (20813341)
2010
3
The relation between Glasgow Coma Scale score and later cerebral atrophy in paediatric traumatic brain injury. (19205959)
2009
4
Retinal vessel abnormalities are associated with elevated fasting insulin levels and cerebral atrophy in nondiabetic individuals. (19376581)
2009
5
Cerebral atrophy after traumatic white matter injury: correlation with acute neuroimaging and outcome. (19072588)
2008
6
Is intracranial atherosclerosis an independent risk factor for cerebral atrophy? A retrospective evaluation. (19102733)
2008
7
Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington's disease. (18831882)
2008
8
Determinants of cerebral atrophy rate at the time of diagnosis of multiple sclerosis. (17296834)
2007
9
Rates of cerebral atrophy differ in different degenerative pathologies. (17347250)
2007
10
Relationship between inflammatory lesions and cerebral atrophy in multiple sclerosis. (16505310)
2006
11
A 24-year follow-up of body mass index and cerebral atrophy. (15557505)
2004
12
Topography of cerebral atrophy in early Huntington's disease: a voxel based morphometric MRI study. (14742591)
2004
13
Cerebral atrophy after acute traumatic subdural or extradural hematomas in adults. (11904078)
2002
14
White matter T(1) relaxation time histograms and cerebral atrophy in multiple sclerosis. (11997065)
2002
15
Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. (12377138)
2002
16
Cerebral atrophy related to corticotherapy in systemic lupus erythematosus (SLE). (11529629)
2001
17
The prevalence of depression in relation to cerebral atrophy and cognitive performance in 70- and 74-year-old women in Gothenburg. The Women's Health Study. (11200959)
2001
18
Rates of global and regional cerebral atrophy in AD and frontotemporal dementia. (11723259)
2001
19
Primary antiphospholipid syndrome and cerebral atrophy: a rare association? (10372845)
1999
20
Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer's disease. (10382699)
1999
21
Parry-Romberg syndrome with ipsilateral cerebral atrophy of neonatal onset. (10651568)
1999
22
Apolipoprotein E in cerebrospinal fluid in 85-year-old subjects. Relation to dementia, apolipoprotein E polymorphism, cerebral atrophy, and white matter lesions. (9074395)
1997
23
Hemispheric cerebral atrophy after traumatic extra-axial hematoma in adults. (9414923)
1997
24
Progression of cerebral atrophy in hemodialysis patients: what about hypertension? (8773374)
1996
25
Progress in the CT evaluation of the cerebral atrophy in acute poisoning with carbon monoxide. (7644693)
1995
26
The relationship of pineal calcification to cerebral atrophy on CT scan in multiple sclerosis. (7960471)
1994
27
Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndrome. (8517682)
1993
28
Localized cerebral atrophy: an important cause of non-Alzheimer's dementia. (8242214)
1993
29
Cerebral atrophy in habitual cocaine abusers: a planimetric CT study. (1985292)
1991
30
Comparative assessment of the disorders of higher brain functions in various types of cerebral atrophy. (1758626)
1991
31
Widened subarachnoid space in pre-discharge cranial ultrasound: evidence of cerebral atrophy in immature infants? (2257986)
1990
32
Progressive dysphasic dementia with localized cerebral atrophy: report of an autopsy. (1703058)
1990
33
Intra- and interobserver variation in CT-evaluated cerebral atrophy. (2849155)
1988
34
Cerebral atrophy and neuropsychological correlates in schizophrenia. (3452986)
1987
35
Controlling for cerebral atrophy in positron emission tomography data. (2956273)
1987
36
Cerebral atrophy in younger persons: a comparative study between clinical examinations and computed tomography. (3621817)
1987
37
Rapid development of cerebral atrophy in systemic lupus erythematosus. (3730739)
1986
38
Cerebral atrophy and nephropathic cystinosis. (3707194)
1986
39
Cerebral atrophy in patients on long-term regular hemodialysis treatment. (3872759)
1985
40
Relation between central cerebral atrophy, memory defects and prolactin secretion. (7178373)
1982
41
CT-scan and EEG findings in professional pugilists: early detection of cerebral atrophy in young boxers. (7182434)
1982
42
Organic mental syndrome and confusional states in Parkinson's disease. Relationship to computerized tomographic signs of cerebral atrophy. (7236060)
1981
43
Cerebral atrophy in anorexia nervosa. (7365589)
1980
44
Differential effects of age and cerebral atrophy upon span of immediate recall and paired-associate learning in older patients suspected of dementia. (477343)
1979
45
Computed tomography scans of alcoholics: cerebral atrophy? (451571)
1979
46
Cerebral atrophy and cognitive impairment in chronic schizophrenia. (62915)
1976
47
Persistence of intraventricular air after pneumoencephalography: its failure to distinguish between cerebral atrophy and normal pressure hydrocephalus. (1226627)
1975
48
ANGIOGRAPHY IN LOCAL CORTICAL CEREBRAL ATROPHY. (14100393)
1963
49
Clinical aspects of cerebral atrophy revealed by encephalography. (13266111)
1955
50
Cerebral atrophy in psychiatric patients. (13207430)
1954

Variations for Cerebral Atrophy

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Expression for genes affiliated with Cerebral Atrophy

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Search GEO for disease gene expression data for Cerebral Atrophy.

Pathways for genes affiliated with Cerebral Atrophy

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Compounds for genes affiliated with Cerebral Atrophy

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Compounds related to Cerebral Atrophy according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1fluorochrome439.8RPS27A, MAPT
2quisqualate43 1210.7MAPT, CREB1
3gelfoam439.7GFAP, MAPT
4cysteamine43 24 1211.6RPS27A, APOE
5tacrine43 1210.5MAPT, APOE
6donepezil43 49 24 1212.4APOE, MAPT
7methamphetamine43 49 1211.4CREB1, RPS27A, GFAP
86-hydroxydopamine439.4CREB1, RPS27A, GFAP
9silver439.4MAPT, RPS27A, GFAP
10diisopropylfluorophosphate439.3MAPT, GFAP
11galantamine43 49 1211.3APOE, MAPT
12formaldehyde43 2410.3MAPT, RPS27A, GFAP
13thioflavine s439.2APOE, RPS27A, MAPT
14chloroquine43 2 49 28 1213.2MAPT, RPS27A, APOE
15gaba439.1GFAP, RPS27A, CREB1
16sodium dodecylsulfate439.1MAPT, RPS27A, APOE
17streptozotocin439.1GFAP, APOE, RPS27A
18isoproterenol43 1210.1GFAP, MAPT, CREB1
19valine439.0MAPT, RPS27A, APOE
20guanine43 24 1211.0CREB1, RPS27A, APOE
21spec-t438.9MAPT, APOE, GFAP
22retinoid438.9CREB1, RPS27A, APOE
23cyclosporin a43 28 5910.9MAPT, RPS27A, SEPSECS, APOE
24butyrate438.9GFAP, RPS27A, MAPT, CREB1
25glycogen43 249.8GFAP, RPS27A, MAPT, CREB1
264-hydroxynonenal43 249.7CREB1, MAPT, RPS27A, APOE
27lactacystin438.7APOE, RPS27A, MAPT, CREB1
28n acetylcysteine438.7APOE, RPS27A, MAPT, CREB1
29actinomycin d438.6APOE, RPS27A, MAPT, CREB1
30formate438.6MAPT, RPS27A, APOE, GFAP
31paraffin438.5GFAP, APOE, RPS27A, MAPT
32lactate438.5GFAP, FH, RPS27A, MAPT, CREB1
33h2o2438.5CREB1, MAPT, RPS27A, APOE
34threonine438.5CREB1, MAPT, RPS27A, GFAP
35kainate43 289.4CREB1, MAPT, APOE, GFAP
36vegf438.2GFAP, APOE, RPS27A, CREB1
37creatinine438.2GFAP, APOE, FH, RPS27A, MAPT
38aspartate438.2GFAP, APOE, FH, RPS27A, MAPT
39zinc43 249.2GFAP, RPS27A, MAPT, CREB1
40nmda43 289.1GFAP, APOE, RPS27A, MAPT, CREB1
41acetylcholine43 49 28 24 1212.1CREB1, MAPT, RPS27A, APOE, GFAP
42glutamine438.1GFAP, APOE, RPS27A, MAPT, CREB1
43dopamine43 28 24 1211.1CREB1, MAPT, RPS27A, APOE, GFAP
44arginine438.1GFAP, APOE, RPS27A, MAPT
45cycloheximide438.1GFAP, APOE, RPS27A, MAPT, CREB1
46testosterone43 59 24 1211.0GFAP, APOE, RPS27A, MAPT, CREB1
47glutamate438.0GFAP, APOE, RPS27A, MAPT, CREB1
48estrogen438.0GFAP, APOE, RPS27A, MAPT, CREB1
49cysteine438.0GFAP, APOE, RPS27A, MAPT, CREB1
50serine437.7GFAP, APOE, SEPSECS, RPS27A, MAPT, CREB1

GO Terms for genes affiliated with Cerebral Atrophy

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Cellular components related to Cerebral Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ribonuclease H2 complexGO:00322999.5RNASEH2C, RNASEH2A, RNASEH2B

Biological processes related to Cerebral Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon productionGO:00324799.9TREX1, RPS27A
2mismatch repairGO:00062989.8RNASEH2A, TREX1
3stress-activated MAPK cascadeGO:00514039.6CREB1, RPS27A
4RNA catabolic processGO:00064019.6RNASEH2C, RNASEH2A, RNASEH2B
5positive regulation of axon extensionGO:00457739.1MAPT, APOE
6innate immune responseGO:00450878.6TREX1, CREB1, RPS27A, SAMHD1

Molecular functions related to Cerebral Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA-DNA hybrid ribonuclease activityGO:00045239.7RNASEH2A, RNASEH2B
2lipoprotein particle bindingGO:00718138.8MAPT, APOE

Products for genes affiliated with Cerebral Atrophy

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Sources for Cerebral Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet