MCID: CRB088
MIFTS: 44

Cerebral Atrophy malady

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Summaries for Cerebral Atrophy

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NINDS:43 Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means loss of cells. In brain tissue, atrophy describes a loss of neurons and the connections between them. Atrophy can be generalized, which means that all of the brain has shrunk; or it can be focal, affecting only a limited area of the brain and resulting in a decrease of the functions that area of the brain controls. If the cerebral hemispheres (the two lobes of the brain that form the cerebrum) are affected, conscious thought and voluntary processes may be impaired.

MalaCards based summary: Cerebral Atrophy is related to dementia and huntington's disease. An important gene associated with Cerebral Atrophy is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways are Signaling by NOTCH2 and Circadian Clock. The compounds fluorochrome and quisqualate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related mouse phenotypes are muscle and growth/size/body.

Wikipedia:65 Cerebral atrophy is a common feature of many of the diseases that affect the brain.Atrophy of any tissue... more...

Aliases & Classifications for Cerebral Atrophy

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Cerebral Atrophy, Aliases & Descriptions:

Name: Cerebral Atrophy 43 62


Related Diseases for Cerebral Atrophy

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Diseases related to Cerebral Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.5GFAP, MAPT, RPS27A, APOE
2huntington's disease30.4MAPT, CREB1, RPS27A
3parkinson's disease30.3RPS27A, APOE, MAPT
4tauopathy30.2RPS27A, MAPT
5progressive supranuclear palsy30.1MAPT, RPS27A, APOE
6multiple system atrophy30.1GFAP, RPS27A, MAPT
7frontotemporal dementia30.0RPS27A, APOE, MAPT
8motor neuron disease30.0RPS27A, MAPT
9alzheimer's disease29.8RPS27A, CREB1, MAPT, GFAP, APOE
10vascular dementia29.8MAPT, RPS27A, APOE
11creutzfeldt-jakob disease29.8MAPT, RPS27A, APOE
12aicardi-goutieres syndrome29.7RNASEH2A, RNASEH2C, SAMHD1, RNASEH2B, TREX1
13memory impairment29.6MAPT, CREB1, APOE
14cerebrovascular disease29.5CREB1, MAPT, APOE
15cerebritis11.2
16multiple sclerosis10.6
17hydrocephalus10.5
18chilblain lupus10.5TREX1
19schizophrenia10.5
20neuronal intranuclear inclusion disease10.5RPS27A
21keratosis follicularis dwarfism and cerebral atrophy10.4
22brain injury10.4
23normal pressure hydrocephalus10.3
24hypertension10.3
25traumatic brain injury10.3
26anorexia nervosa10.3
27semantic dementia10.3RPS27A, MAPT
28primary progressive aphasia10.3MAPT, RPS27A
29inclusion body myositis10.2MAPT, RPS27A
30systemic lupus erythematosus10.2
31lupus erythematosus10.2
32retinitis10.2
33alexander disease10.2GFAP, RPS27A
34dentatorubral-pallidoluysian atrophy10.2CREB1, RPS27A
35alcohol abuse10.2CREB1, RPS27A
36spinocerebellar ataxia10.2MAPT, RPS27A
37movement disease10.2RPS27A, MAPT
38atherosclerosis10.2
39head injury10.2
40x-linked intellectual disability - dysmorphism - cerebral atrophy10.2
41age related macular degeneration10.2APOE
42binswanger's disease10.1MAPT, GFAP
43hemorrhage, intracerebral10.1APOE, RPS27A
44myositis10.1RPS27A, MAPT
45diabetes mellitus10.1
46acquired immunodeficiency syndrome10.1
47diabetic encephalopathy10.1
48secondary progressive multiple sclerosis10.1
49incontinentia pigmenti achromians10.1
50neuropathy10.1

Graphical network of the top 20 diseases related to Cerebral Atrophy:



Diseases related to cerebral atrophy

Symptoms for Cerebral Atrophy

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Drugs & Therapeutics for Cerebral Atrophy

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Drug clinical trials:

Search ClinicalTrials for Cerebral Atrophy

Search NIH Clinical Center for Cerebral Atrophy

Genetic Tests for Cerebral Atrophy

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Anatomical Context for Cerebral Atrophy

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MalaCards organs/tissues related to Cerebral Atrophy:

32
Brain, Testes, Temporal lobe, Kidney, Liver, Thyroid, Pineal

Animal Models for Cerebral Atrophy or affiliated genes

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MGI Mouse Phenotypes related to Cerebral Atrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.6GFAP, APOE, MAPT, CREB1, TREX1
2MP:00053787.3TREX1, CREB1, MAPT, RNASEH2B, APOE, GFAP
3MP:00053877.0GFAP, APOE, RNASEH2B, SAMHD1, MAPT, TREX1
4MP:00053846.4GFAP, APOE, RNASEH2B, SAMHD1, FH, MAPT
5MP:00107686.2TREX1, GFAP, APOE, RNASEH2B, RNASEH2C, SAMHD1

Publications for Cerebral Atrophy

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Articles related to Cerebral Atrophy:

(show top 50)    (show all 379)
idTitleAuthorsYear
1
Retraction. Francis GJ, Martinez JA, Liu WQ, Xu K, Ayer A, Fine J, Tuor UI, Glazner G, Hanson LR, Frey WH 2nd, Toth C. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008 Dec;131(Pt 12):3311a8934. doi:10.1093/brain/awn288. (24860127)
2014
2
Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. (20576949)
2010
3
Cerebral atrophy, apolipoprotein E varepsilon4, and rate of decline in everyday function among patients with amnestic mild cognitive impairment. (20813341)
2010
4
The relation between Glasgow Coma Scale score and later cerebral atrophy in paediatric traumatic brain injury. (19205959)
2009
5
Retinal vessel abnormalities are associated with elevated fasting insulin levels and cerebral atrophy in nondiabetic individuals. (19376581)
2009
6
Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. (19270764)
2009
7
Cerebral atrophy after traumatic white matter injury: correlation with acute neuroimaging and outcome. (19072588)
2008
8
Is intracranial atherosclerosis an independent risk factor for cerebral atrophy? A retrospective evaluation. (19102733)
2008
9
Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington's disease. (18831882)
2008
10
Determinants of cerebral atrophy rate at the time of diagnosis of multiple sclerosis. (17296834)
2007
11
Rates of cerebral atrophy differ in different degenerative pathologies. (17347250)
2007
12
Relationship between inflammatory lesions and cerebral atrophy in multiple sclerosis. (16505310)
2006
13
A 24-year follow-up of body mass index and cerebral atrophy. (15557505)
2004
14
Topography of cerebral atrophy in early Huntington's disease: a voxel based morphometric MRI study. (14742591)
2004
15
Cerebral atrophy after acute traumatic subdural or extradural hematomas in adults. (11904078)
2002
16
White matter T(1) relaxation time histograms and cerebral atrophy in multiple sclerosis. (11997065)
2002
17
Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. (12377138)
2002
18
Cerebral atrophy related to corticotherapy in systemic lupus erythematosus (SLE). (11529629)
2001
19
The prevalence of depression in relation to cerebral atrophy and cognitive performance in 70- and 74-year-old women in Gothenburg. The Women's Health Study. (11200959)
2001
20
Rates of global and regional cerebral atrophy in AD and frontotemporal dementia. (11723259)
2001
21
Primary antiphospholipid syndrome and cerebral atrophy: a rare association? (10372845)
1999
22
Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer's disease. (10382699)
1999
23
Parry-Romberg syndrome with ipsilateral cerebral atrophy of neonatal onset. (10651568)
1999
24
Apolipoprotein E in cerebrospinal fluid in 85-year-old subjects. Relation to dementia, apolipoprotein E polymorphism, cerebral atrophy, and white matter lesions. (9074395)
1997
25
Hemispheric cerebral atrophy after traumatic extra-axial hematoma in adults. (9414923)
1997
26
Progression of cerebral atrophy in hemodialysis patients: what about hypertension? (8773374)
1996
27
Progress in the CT evaluation of the cerebral atrophy in acute poisoning with carbon monoxide. (7644693)
1995
28
The relationship of pineal calcification to cerebral atrophy on CT scan in multiple sclerosis. (7960471)
1994
29
Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndrome. (8517682)
1993
30
Localized cerebral atrophy: an important cause of non-Alzheimer's dementia. (8242214)
1993
31
Cerebral atrophy in habitual cocaine abusers: a planimetric CT study. (1985292)
1991
32
Comparative assessment of the disorders of higher brain functions in various types of cerebral atrophy. (1758626)
1991
33
Widened subarachnoid space in pre-discharge cranial ultrasound: evidence of cerebral atrophy in immature infants? (2257986)
1990
34
Progressive dysphasic dementia with localized cerebral atrophy: report of an autopsy. (1703058)
1990
35
Intra- and interobserver variation in CT-evaluated cerebral atrophy. (2849155)
1988
36
Controlling for cerebral atrophy in positron emission tomography data. (2956273)
1987
37
Cerebral atrophy in younger persons: a comparative study between clinical examinations and computed tomography. (3621817)
1987
38
Rapid development of cerebral atrophy in systemic lupus erythematosus. (3730739)
1986
39
Cerebral atrophy and nephropathic cystinosis. (3707194)
1986
40
Cerebral atrophy in patients on long-term regular hemodialysis treatment. (3872759)
1985
41
Relation between central cerebral atrophy, memory defects and prolactin secretion. (7178373)
1982
42
CT-scan and EEG findings in professional pugilists: early detection of cerebral atrophy in young boxers. (7182434)
1982
43
Cerebral atrophy in anorexia nervosa. (7365589)
1980
44
Differential effects of age and cerebral atrophy upon span of immediate recall and paired-associate learning in older patients suspected of dementia. (477343)
1979
45
Computed tomography scans of alcoholics: cerebral atrophy? (451571)
1979
46
Cerebral atrophy and cognitive impairment in chronic schizophrenia. (62915)
1976
47
Persistence of intraventricular air after pneumoencephalography: its failure to distinguish between cerebral atrophy and normal pressure hydrocephalus. (1226627)
1975
48
ANGIOGRAPHY IN LOCAL CORTICAL CEREBRAL ATROPHY. (14100393)
1963
49
Clinical aspects of cerebral atrophy revealed by encephalography. (13266111)
1955
50
Cerebral atrophy in psychiatric patients. (13207430)
1954

Variations for Cerebral Atrophy

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Expression for genes affiliated with Cerebral Atrophy

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Expression patterns in normal tissues for genes affiliated with Cerebral Atrophy

Search GEO for disease gene expression data for Cerebral Atrophy.

Pathways for genes affiliated with Cerebral Atrophy

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Compounds for genes affiliated with Cerebral Atrophy

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Compounds related to Cerebral Atrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1fluorochrome449.8MAPT, RPS27A
2quisqualate44 1110.7MAPT, CREB1
3gelfoam449.7MAPT, GFAP
4cysteamine44 24 1111.6APOE, RPS27A
5tacrine44 1110.5MAPT, APOE
6donepezil44 50 24 1112.4APOE, MAPT
7methamphetamine44 50 1111.4GFAP, RPS27A, CREB1
86-hydroxydopamine449.4CREB1, GFAP, RPS27A
9silver449.4GFAP, MAPT, RPS27A
10diisopropylfluorophosphate449.3GFAP, MAPT
11galantamine44 50 1111.3APOE, MAPT
12formaldehyde44 2410.3GFAP, MAPT, RPS27A
13thioflavine s449.2APOE, RPS27A, MAPT
14chloroquine44 2 50 28 1113.2RPS27A, MAPT, APOE
15gaba449.1CREB1, RPS27A, GFAP
16sodium dodecylsulfate449.1RPS27A, APOE, MAPT
17streptozotocin449.1RPS27A, GFAP, APOE
18isoproterenol44 1110.1GFAP, CREB1, MAPT
19valine449.0RPS27A, MAPT, APOE
20guanine44 24 1111.0APOE, CREB1, RPS27A
21spec-t448.9MAPT, GFAP, APOE
22retinoid448.9RPS27A, APOE, CREB1
23cyclosporin a44 28 6110.9RPS27A, MAPT, SEPSECS, APOE
24butyrate448.9CREB1, MAPT, GFAP, RPS27A
25glycogen44 249.8MAPT, CREB1, GFAP, RPS27A
264-hydroxynonenal44 249.7APOE, MAPT, RPS27A, CREB1
27lactacystin448.7MAPT, RPS27A, CREB1, APOE
28n acetylcysteine448.7MAPT, APOE, CREB1, RPS27A
29actinomycin d448.6CREB1, MAPT, RPS27A, APOE
30formate448.6APOE, GFAP, MAPT, RPS27A
31paraffin448.5GFAP, RPS27A, MAPT, APOE
32lactate448.5RPS27A, MAPT, CREB1, FH, GFAP
33h2o2448.5APOE, CREB1, MAPT, RPS27A
34threonine448.5GFAP, CREB1, MAPT, RPS27A
35kainate44 289.4MAPT, CREB1, GFAP, APOE
36vegf448.2GFAP, APOE, RPS27A, CREB1
37creatinine448.2FH, RPS27A, MAPT, GFAP, APOE
38aspartate448.2APOE, GFAP, RPS27A, MAPT, FH
39zinc44 249.2GFAP, RPS27A, MAPT, CREB1
40nmda44 289.1MAPT, APOE, RPS27A, GFAP, CREB1
41acetylcholine44 50 28 24 1112.1CREB1, RPS27A, APOE, GFAP, MAPT
42glutamine448.1GFAP, APOE, RPS27A, MAPT, CREB1
43dopamine44 28 24 1111.1CREB1, RPS27A, MAPT, APOE, GFAP
44arginine448.1APOE, GFAP, MAPT, RPS27A
45cycloheximide448.1MAPT, RPS27A, APOE, GFAP, CREB1
46testosterone44 61 24 1111.0CREB1, APOE, MAPT, RPS27A, GFAP
47glutamate448.0GFAP, CREB1, APOE, RPS27A, MAPT
48estrogen448.0CREB1, GFAP, MAPT, RPS27A, APOE
49cysteine448.0APOE, RPS27A, MAPT, CREB1, GFAP
50serine447.7CREB1, SEPSECS, RPS27A, MAPT, GFAP, APOE

GO Terms for genes affiliated with Cerebral Atrophy

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Cellular components related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribonuclease H2 complexGO:0322999.5RNASEH2C, RNASEH2A, RNASEH2B

Biological processes related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon productionGO:0324799.9TREX1, RPS27A
2mismatch repairGO:0062989.8RNASEH2A, TREX1
3stress-activated MAPK cascadeGO:0514039.6CREB1, RPS27A
4RNA catabolic processGO:0064019.6RNASEH2C, RNASEH2A, RNASEH2B
5positive regulation of axon extensionGO:0457739.1MAPT, APOE
6innate immune responseGO:0450878.6TREX1, CREB1, RPS27A, SAMHD1

Molecular functions related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA-DNA hybrid ribonuclease activityGO:0045239.7RNASEH2A, RNASEH2B
2lipoprotein particle bindingGO:0718138.8MAPT, APOE

Products for genes affiliated with Cerebral Atrophy

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Sources for Cerebral Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet