MCID: CRB088
MIFTS: 33

Cerebral Atrophy malady

Summaries for Cerebral Atrophy

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means loss of cells. In brain tissue, atrophy describes a loss of neurons and the connections between them. Atrophy can be generalized, which means that all of the brain has shrunk; or it can be focal, affecting only a limited area of the brain and resulting in a decrease of the functions that area of the brain controls. If the cerebral hemispheres (the two lobes of the brain that form the cerebrum) are affected, conscious thought and voluntary processes may be impaired.

MalaCards: Cerebral Atrophy is related to dementia and hydrocephalus. An important gene associated with Cerebral Atrophy is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways are Regulation of innate immune responses to cytosolic DNA and Lagging Strand Synthesis. The compounds cycloheximide and tacrine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are renal/urinary system and muscle.

Wikipedia:63 Cerebral atrophy is a common feature of many of the diseases that affect the brain.Atrophy of any tissue... more...

Aliases & Classifications for Cerebral Atrophy

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43NINDS, 60UMLS
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Aliases & Descriptions:

cerebral atrophy 43 60


Related Diseases for Cerebral Atrophy

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.9MAPT, RPS27A, APOE, CLN5, GFAP
2hydrocephalus30.7MAPT
3parkinson's disease30.5APOE, RPS27A, MAPT
4lupus erythematosus30.2TREX1
5huntington's disease30.2MAPT, RPS27A, CREB1
6progressive supranuclear palsy30.1APOE, MAPT, RPS27A
7aphasia30.0MAPT
8lewy body dementia30.0MAPT, APOE
9frontotemporal dementia30.0MAPT, RPS27A, APOE
10multiple system atrophy30.0GFAP, MAPT, RPS27A
11hepatitis29.8SEPSECS
12motor neuron disease29.8MAPT, RPS27A
13encephalitis29.8GFAP
14vascular dementia29.8APOE, MAPT, RPS27A
15aicardi-goutieres syndrome29.8TREX1, SAMHD1, RNASEH2A, RNASEH2B, RNASEH2C
16cerebritis11.2
17multiple sclerosis10.5
18alzheimer's disease10.4
19schizophrenia10.4
20keratosis follicularis dwarfism and cerebral atrophy10.3
21normal pressure hydrocephalus10.3
22anorexia nervosa10.2
23hypertension10.2
24systemic lupus erythematosus10.2
25retinitis10.2
26cerebral atherosclerosis10.1
27atherosclerosis10.1
28cerebral palsy10.1
29intellectual deficit, x-linked - dysmorphism - cerebral atrophy10.1
30relapsing-remitting multiple sclerosis10.0
31acquired immunodeficiency syndrome10.0
32secondary progressive multiple sclerosis10.0
33neuropathy10.0
34uremia10.0
35vascular disease10.0
36progressive cerebello-cerebral atrophy10.0
37autosomal recessive cerebral atrophy10.0
38chilblain lupus10.0TREX1
39scrapie10.0MAPT
40brain ischemia10.0MAPT
41neuronal intranuclear inclusion disease10.0RPS27A
42semantic dementia10.0MAPT, RPS27A
43primary progressive aphasia10.0RPS27A, MAPT
44myositis10.0MAPT, RPS27A
45visual epilepsy10.0TPP1, CLN6
46inclusion body myositis10.0MAPT, RPS27A
47prion disease10.0GFAP
48cerebral amyloid angiopathy10.0MAPT, APOE
49brain disease10.0FH, MAPT, CLN5
50alzheimer disease type 210.0MAPT, APOE

Graphical network of the top 20 diseases related to Cerebral Atrophy:



Diseases related to cerebral atrophy

Clinical Features for Cerebral Atrophy

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Drugs & Therapeutics for Cerebral Atrophy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Cerebral Atrophy

Search NIH Clinical Center for Cerebral Atrophy

Search CenterWatch for Cerebral Atrophy

Genetic Tests for Cerebral Atrophy

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Anatomical Context for Cerebral Atrophy

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32MalaCards
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MalaCards organs/tissues related to Cerebral Atrophy:

32
Brain

Animal Models for Cerebral Atrophy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cerebral Atrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5CLN3, MAPT, TREX1, PPT1, APOE, FH
2MP:00053697.5APOE, PPT1, CREB1, TREX1, MAPT, DNAJC5
3MP:00053917.4GFAP, APOE, PPT1, TREX1, MAPT, DNAJC5
4MP:00053866.8APOE, PPT1, CREB1, MAPT, DNAJC5, CLN8
5MP:00036316.4APOE, PPT1, CREB1, MAPT, DNAJC5, RNASEH2B
6MP:00107686.0MAPT, TREX1, CREB1, PPT1, APOE, FH

Publications for Cerebral Atrophy

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Genetic Variations for Cerebral Atrophy

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Expression for genes affiliated with Cerebral Atrophy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Atrophy

Search GEO for disease gene expression data for Cerebral Atrophy.

Pathways for genes affiliated with Cerebral Atrophy

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53Reactome, 29KEGG, 4Cell Signaling Technology
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Pathways related to Cerebral Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TREX1, RPS27A
2
Hide members
9.8RNASEH2A, RNASEH2B, RNASEH2C
39.2PPT1, CLN3, CLN5, TPP1
48.6APOE, CREB1, MAPT, GFAP

Compounds for genes affiliated with Cerebral Atrophy

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Cerebral Atrophy according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5MAPT
2tacrine44 1111.0APOE, MAPT
3donepezil44 11 2411.9MAPT, APOE
4thioflavine s449.9MAPT, APOE, RPS27A
5gelfoam449.9GFAP, MAPT
6cysteamine44 11 2411.7APOE, RPS27A
7chloroquine44 2 49 28 1113.7MAPT, APOE, RPS27A
8quisqualate44 1110.7CREB1, MAPT
9sodium dodecylsulfate449.6RPS27A, APOE, MAPT
10palmitate449.6DNAJC5, PPT1, APOE, RPS27A
11silver449.6RPS27A, MAPT, GFAP
12mannose 6-phosphate44 2410.5TPP1, CLN3, PPT1
13spec-t449.5APOE, MAPT, GFAP
14streptozotocin449.5GFAP, APOE, RPS27A
15methamphetamine44 49 1111.4GFAP, CREB1, RPS27A
166-hydroxydopamine449.4RPS27A, CREB1, GFAP
174-hydroxynonenal44 2410.4RPS27A, APOE, CREB1, MAPT
18lactacystin449.3MAPT, CREB1, APOE, RPS27A
19formate449.3GFAP, MAPT, APOE, RPS27A
20nmda44 2810.2RPS27A, APOE, MAPT, GFAP
21n acetylcysteine449.2MAPT, CREB1, APOE, RPS27A
22butyrate449.0GFAP, MAPT, CREB1, RPS27A
23kainate44 2810.0APOE, CREB1, MAPT, GFAP
24creatinine448.8GFAP, MAPT, APOE, FH, RPS27A
25lactate448.8GFAP, MAPT, CREB1, FH, RPS27A
26acetylcholine44 49 28 11 2412.7RPS27A, APOE, CREB1, MAPT, GFAP
27glycogen44 249.7RPS27A, CREB1, MAPT, GFAP
28glutamine448.7RPS27A, APOE, CREB1, MAPT, GFAP
29dopamine44 28 11 2411.7RPS27A, APOE, CREB1, MAPT, GFAP
30actinomycin d448.6MAPT, CREB1, APOE, RPS27A
31aspartate448.6RPS27A, FH, APOE, MAPT, GFAP, TPP1
32testosterone44 59 11 2411.5GFAP, MAPT, CREB1, APOE, RPS27A
33glutamate448.3RPS27A, APOE, CREB1, MAPT, CLN3, GFAP
34cysteine448.1RPS27A, APOE, PPT1, CREB1, MAPT, DNAJC5
35atp44 289.1RPS27A, FH, PPT1, CREB1, CLN3, GFAP
36lipid448.0APOE, PPT1, CREB1, CLN8, CLN6, CLN3
37serine447.5RPS27A, APOE, PPT1, CREB1, MAPT, CLN3

GO Terms for genes affiliated with Cerebral Atrophy

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16Gene Ontology
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Cellular components related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribonuclease H2 complexGO:0322999.7RNASEH2C, RNASEH2B, RNASEH2A
2synaptic vesicleGO:0080219.6CLN3, PPT1, DNAJC5
3lysosomeGO:0057648.9TPP1, PPT1, CLN3, CLN5

Biological processes related to Cerebral Atrophy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1RNA catabolic processGO:00640110.1RNASEH2A, RNASEH2C, RNASEH2B
2cellular protein catabolic processGO:04425710.0PPT1, CLN8
3regulation of type I interferon productionGO:03247910.0RPS27A, TREX1
4negative regulation of proteolysisGO:0458619.9CLN8, CLN3
5associative learningGO:0083069.8CLN3, CLN8, PPT1
6regulation of cell sizeGO:0083619.8CREB1, CLN8
7ceramide metabolic processGO:0066729.8CLN3, CLN8
8lysosome organizationGO:0070409.8CLN3, CLN8, TPP1
9neuromuscular process controlling balanceGO:0508859.8CLN3, CLN8, TPP1
10cholesterol metabolic processGO:0082039.7CLN8, CLN6, APOE
11visual perceptionGO:0076019.7CLN5, CLN6, CLN8, PPT1
12lysosomal lumen acidificationGO:0070429.6CLN6, CLN3, CLN5, PPT1
13receptor-mediated endocytosisGO:0068989.5CLN3, PPT1, APOE
14positive regulation of axon extensionGO:0457739.5APOE, MAPT
15negative regulation of neuron apoptotic processGO:0435249.3APOE, PPT1, CLN3, DNAJC5
16protein catabolic processGO:0301639.1TPP1, PPT1, CLN8, CLN6, CLN3, CLN5
17cell deathGO:0082198.5CLN8, CLN6, APOE, CLN3, CLN5, TREX1

Molecular functions related to Cerebral Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.8MAPT, APOE

Products for genes affiliated with Cerebral Atrophy

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Sources for Cerebral Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet