MCID: CRB085
MIFTS: 39

Cerebral Hemorrhage malady

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Summaries for Cerebral Hemorrhage

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Wikipedia:65 A cerebral haemorrhage (also spelled hemorrhage; aka intracranial hemorrhage, cerebral hematoma,... more...

MalaCards based summary: Cerebral Hemorrhage is related to amyloidosis and cerebral amyloid angiopathy. An important gene associated with Cerebral Hemorrhage is CST3 (cystatin C), and among its related pathways are A-beta Plaque Formation and APP Metabolism and Response to elevated platelet cytosolic Ca2+. The compounds vitamin b6 and leupeptin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and neutrophil, and related mouse phenotypes are homeostasis/metabolism and muscle.

Aliases & Classifications for Cerebral Hemorrhage

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Cerebral Hemorrhage, Aliases & Descriptions:

Name: Cerebral Hemorrhage 30 62


Related Diseases for Cerebral Hemorrhage

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Diseases related to Cerebral Hemorrhage via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.4APP, CST3
2cerebral amyloid angiopathy30.8APP, HSPB6, CST3
3aneurysm30.1LOX, CST3
4alzheimer's disease29.4APP, CST3, AGRN, HSPB6, HSPB8, LOX
5cerebritis11.1
6hereditary cerebral hemorrhage with amyloidosis10.9
7oral submucous fibrosis10.4LOX
8hypertension10.4
9cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.4
10dementia10.3
11brain edema10.2
12endocarditis10.2
13prion disease10.2CST3, APP
14vascular dementia10.1APP, CST3
15creutzfeldt-jakob disease10.1APP, CST3
16amyloid tumor10.1CST3, APP
17cerebrovascular disease10.1CST3, APP
18brain injury10.1
19leukemia10.1
20traumatic brain injury10.1
21moyamoya disease10.1
22nephrosclerosis10.1
23neuronitis10.1
24infective endocarditis10.1
25purpura10.1
26hereditary cerebral amyloid angiopathy10.1
27tetanus10.0APP, CST3
28ischemia10.0HSPB8, HSPB6, CST3
29hemorrhage, intracerebral10.0CST3, APP, SERPINF2
30west syndrome9.9
31glomerulonephritis9.9
32malaria9.9
33multiple sclerosis9.9
34osteopetrosis9.9
35systemic lupus erythematosus9.9
36antiphospholipid syndrome9.9
37cryoglobulinemia9.9
38factor xi deficiency9.9
39congenital afibrinogenemia9.9
40acute poststreptococcal glomerulonephritis9.9
41cerebral malaria9.9
42fabry disease9.9
43cardiac tamponade9.9
44diabetic ketoacidosis9.9
45hypoglycemic coma9.9
46eclampsia9.9
47alexia9.9
48cadasil9.9
49hypertensive encephalopathy9.9
50subacute bacterial endocarditis9.9

Graphical network of the top 20 diseases related to Cerebral Hemorrhage:



Diseases related to cerebral hemorrhage

Symptoms for Cerebral Hemorrhage

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Drugs & Therapeutics for Cerebral Hemorrhage

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Drug clinical trials:

Search ClinicalTrials for Cerebral Hemorrhage

Search NIH Clinical Center for Cerebral Hemorrhage

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Cerebral Hemorrhage cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cerebral Hemorrhage:
GLP-1 CellBeads
Embryonic/Adult Cultured Cells Related to Cerebral Hemorrhage:
GLP-transfected mesenchymal stem cells, PMIDs: 22985173, 22034462

Genetic Tests for Cerebral Hemorrhage

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Anatomical Context for Cerebral Hemorrhage

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MalaCards organs/tissues related to Cerebral Hemorrhage:

32
Brain, Heart, Neutrophil, Pituitary

Animal Models for Cerebral Hemorrhage or affiliated genes

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MGI Mouse Phenotypes related to Cerebral Hemorrhage:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0APP, SERPINF2, LOX, CST3, HSPB8
2MP:00053697.4AGRN, CST3, LOX, APP, HSPB8

Publications for Cerebral Hemorrhage

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Articles related to Cerebral Hemorrhage:

(show top 50)    (show all 163)
idTitleAuthorsYear
1
Initial diagnosis of the congenital disorder of glycosylation PMM2-CDG (CDG1a) in a 4-year-old girl after neurosurgical intervention for cerebral hemorrhage. (25192236)
2014
2
Effects of High-Pressure Oxygen Therapy on Brain Tissue Water Content and AQP4 Expression in Rabbits with Cerebral Hemorrhage. (25064222)
2014
3
Association of CVD candidate gene polymorphisms with ischemic stroke and cerebral hemorrhage in Chinese individuals. (25144711)
2014
4
Multiple cerebral hemorrhagic foci from metastases during temozolomide treatment in a patient with corticotroph pituitary carcinoma. (24823463)
2014
5
Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the national institute of neurological disorders and stroke tissue-type plasminogen activator trials. (25096731)
2014
6
Association of variants in KCNK17 gene with ischemic stroke and cerebral hemorrhage in a Chinese population. (25179130)
2014
7
Intravenous immunoglobulin in Henoch-SchAPnlein purpura complicated by cerebral hemorrhage. (22829413)
2013
8
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. (23857095)
2013
9
Cerebral microbleeds (CMBs) - relevance for mechanisms of cerebral hemorrhage--analysis of 24 MRI evaluated patients. (24868257)
2013
10
Diabetic ketoacidosis with cerebral hemorrhage and alpha coma in an adolescent female. (23515102)
2013
11
Cerebral hemorrhage, brain edema, and heme oxygenase-1 expression after experimental traumatic brain injury. (23564109)
2013
12
Fibrinogen polymorphisms associated with sporadic cerebral hemorrhage in a Chinese population. (22386478)
2012
13
Infective endocarditis complicated by fatal cerebral hemorrhage revealing an unrepaired univentricular heart in a 19-year-old woman. (21547931)
2011
14
The clinical significance of S100I^ protein in cerebrospinal fluid and serum from the patients with cerebral hemorrhage]. (21906477)
2011
15
Histopathological analysis of cerebral hemorrhage in systemic lupus erythematosus complicated with antiphospholipid syndrome. (21318307)
2011
16
Association between polymorphism of rs3212855 and rs5515 of KLK1 gene with cerebral hemorrhage in Changsha Han population]. (21200088)
2010
17
Hereditary cerebral hemorrhage with amyloidosis associated with the E693K mutation of APP. (20697050)
2010
18
The potential of capillary birthmarks as a significant marker for capillary malformation-arteriovenous malformation syndrome in children who had nontraumatic cerebral hemorrhage. (21129558)
2010
19
Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)
2009
20
Cerebral vascular accumulation of Dutch-type Abeta42, but not wild-type Abeta42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type. (17628026)
2007
21
Large acute cerebral hemorrhage presenting with pure alexia. (17083996)
2007
22
Hereditary cerebral hemorrhage with amyloidosis-Dutch type. (16382777)
2005
23
Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. (15014955)
2004
24
Association between alpha-1-antichymotrypsin gene polymorphism and cerebral hemorrhage]. (12126519)
2002
25
Enhanced Abeta40 deposition was associated with increased Abeta42-43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D). (12480745)
2002
26
Cellular processing of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. (10524281)
1999
27
Cerebral hemorrhage and apoE. (10525983)
1999
28
A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension. (9759612)
1998
29
Microvasculopathy is associated with the number of cerebrovascular lesions in hereditary cerebral hemorrhage with amyloidosis, Dutch type. (9707198)
1998
30
Instability of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. (9565605)
1998
31
Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D). (9542588)
1998
32
Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. (8644866)
1996
33
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): II--A review of histopathological aspects. (8737927)
1996
34
Hereditary cerebral hemorrhage with amyloidosis-Dutch type: better correlation of cognitive deterioration with advancing age than with number of focal lesions or white matter hyperintensities. (8939282)
1996
35
Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. (7654074)
1995
36
Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology. (7839831)
1994
37
High colloid oncotic therapy for brain edema with cerebral hemorrhage. (7976652)
1994
38
Cerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly. (8336159)
1993
39
Morphology of cerebral plaque-like lesions in hereditary cerebral hemorrhage with amyloidosis (Dutch). (1471474)
1992
40
Progressive dementia, without cerebral hemorrhage, in a patient with hereditary cerebral amyloid angiopathy. (1335860)
1992
41
Acute-phase proteins in stroke: influences of its cause (cerebral hemorrhage or infarction), of the cerebral site of infarction, and of the sex of patients. (1716456)
1991
42
Hemopericardium following cerebral hemorrhage. Report of an autopsy case. (1836300)
1991
43
Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Tc-99m HM-PAO single photon emission computed tomography. (2398939)
1990
44
Diagnosis of cerebral amyloid angiopathy with cerebral hemorrhage by enzyme linked immunosorbent assay (ELISA) of cystatin C in the cerebrospinal fluid]. (2364630)
1990
45
Hereditary cerebral hemorrhage. Dementia with cystatin C amyloidosis]. (2320403)
1990
46
A case of acute poststreptococcal glomerulonephritis associated with cerebral hemorrhage. (3694896)
1987
47
Abnormal metabolism of gamma-trace alkaline microprotein. The basic defect in hereditary cerebral hemorrhage with amyloidosis. (6390199)
1984
48
VA clinical pathological conference: cerebral hemorrhage associated with malignant nephrosclerosis and cardiac hypertrophy. (13013101)
1952
49
Massive cerebral hemorrhage following heparin therapy in subacute bacterial endocarditis; report of two cases with a review of the literature. (15394693)
1949
50
Changes in cerebral veins in hypertensive brain disease and their relation to cerebral hemorrhage; clinical pathologic study. (21012278)
1945

Variations for Cerebral Hemorrhage

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Expression for genes affiliated with Cerebral Hemorrhage

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Expression patterns in normal tissues for genes affiliated with Cerebral Hemorrhage

Search GEO for disease gene expression data for Cerebral Hemorrhage.

Pathways for genes affiliated with Cerebral Hemorrhage

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Pathways related to Cerebral Hemorrhage according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CST3, APP
2
Show member pathways
9.3SERPINF2, APP

Compounds for genes affiliated with Cerebral Hemorrhage

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Compounds related to Cerebral Hemorrhage according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1vitamin b6449.9CST3, LOX
2leupeptin449.8CST3, APP
3aprotinin44 1110.8CST3, SERPINF2
4captopril44 61 50 28 1113.7CST3, APP
56-hydroxydopamine449.7APP, CST3
6Hydrogen peroxide249.6LOX, APP
7ndga449.6APP, LOX
8gold449.6CST3, LOX
9ibuprofen44 28 50 24 1113.5LOX, APP
10homocysteine44 2410.5CST3, LOX
11urea44 24 1111.4SERPINF2, LOX, CST3
12sodium dodecylsulfate449.4SERPINF2, APP
13kininogen449.3CST3, SERPINF2, APP
14glycosaminoglycan449.2AGRN, LOX
15glutamine449.2CST3, SERPINF2, APP
16sialic acid449.1AGRN, CST3, SERPINF2
17cholesterol44 28 24 1112.1APP, SERPINF2, CST3
18matrigel449.1LOX, CST3, AGRN
19polysaccharide449.1AGRN, CST3, SERPINF2
20dexamethasone44 50 28 1112.0APP, LOX, CST3
21vegf448.8CST3, LOX, SERPINF2, APP
22heparin44 28 24 1111.7AGRN, SERPINF2, APP
23arginine448.7CST3, SERPINF2, APP
24serine448.1HSPB6, APP, SERPINF2, CST3, AGRN
25lipid448.0AGRN, CST3, LOX, SERPINF2, APP

GO Terms for genes affiliated with Cerebral Hemorrhage

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Cellular components related to Cerebral Hemorrhage according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3SERPINF2, APP
2cell surfaceGO:0099868.2AGRN, SERPINF2, APP
3extracellular spaceGO:0056158.1SERPINF2, LOX, CST3, AGRN
4extracellular regionGO:0055767.6AGRN, CST3, LOX, SERPINF2, APP

Biological processes related to Cerebral Hemorrhage according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to stressGO:0069509.5HSPB6, HSPB8
2collagen fibril organizationGO:0301999.4SERPINF2, LOX
3negative regulation of endopeptidase activityGO:0109519.1CST3, SERPINF2, APP
4platelet degranulationGO:0025769.0SERPINF2, APP
5extracellular matrix organizationGO:0301988.6AGRN, LOX, APP
6positive regulation of transcription from RNA polymerase II promoterGO:0459448.5AGRN, SERPINF2, APP

Molecular functions related to Cerebral Hemorrhage according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.5CST3, SERPINF2
2serine-type endopeptidase inhibitor activityGO:0048679.3SERPINF2, APP
3protease bindingGO:0020209.3CST3, SERPINF2
4protein bindingGO:0055156.7AGRN, HSPB8, HSPB6, APP, SERPINF2, LOX

Products for genes affiliated with Cerebral Hemorrhage

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  • Antibodies
  • Proteins
  • Lysates

Sources for Cerebral Hemorrhage

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet