Aliases & Classifications for Cerebral Hemorrhage

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Cerebral Hemorrhage, Aliases & Descriptions:

Name: Cerebral Hemorrhage 30 60


Summaries for Cerebral Hemorrhage

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Wikipedia:63 A cerebral haemorrhage (also spelled hemorrhage; aka intracranial hemorrhage, cerebral hematoma,... more...

MalaCards based summary: Cerebral Hemorrhage is related to amyloidosis and cerebral amyloid angiopathy. An important gene associated with Cerebral Hemorrhage is CST3 (cystatin C), and among its related pathways are A-beta Plaque Formation and APP Metabolism and Response to elevated platelet cytosolic Ca2+. The compounds vitamin b6 and leupeptin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and neutrophil, and related mouse phenotypes are homeostasis/metabolism and muscle.

Related Diseases for Cerebral Hemorrhage

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Diseases related to Cerebral Hemorrhage via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.3APP, CST3
2cerebral amyloid angiopathy30.9APP, HSPB6, CST3
3aneurysm30.3LOX, CST3
4hemorrhage, intracerebral29.8CST3, APP, SERPINF2
5alzheimer disease29.1APP, CST3, AGRN, HSPB6, HSPB8, LOX
6cerebritis11.1
7oral submucous fibrosis10.4LOX
8dementia10.2
9brain edema10.2
10endocarditis10.2
11hereditary cerebral hemorrhage with amyloidosis, flemish type10.2
12hereditary cerebral hemorrhage with amyloidosis, italian type10.2
13hereditary cerebral hemorrhage with amyloidosis, arctic type10.2
14hereditary cerebral hemorrhage with amyloidosis, iowa type10.2
15hereditary cerebral hemorrhage with amyloidosis, piedmont type10.2
16prion disease10.1CST3, APP
17vascular dementia10.1APP, CST3
18creutzfeldt-jakob disease10.1APP, CST3
19cerebrovascular disease10.1CST3, APP
20pheochromocytoma10.1
21moyamoya disease10.1
22cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.1
23brain injury10.1
24leukemia10.1
25traumatic brain injury10.1
26neuronitis10.1
27nephrosclerosis10.1
28eclampsia10.1
29infective endocarditis10.1
30purpura10.1
31hereditary cerebral amyloid angiopathy10.1
32tetanus10.0APP, CST3
33ischemia10.0HSPB8, HSPB6, CST3
34systemic lupus erythematosus9.9
35erythrocytosis, familial, 29.9
36cerebral cavernous malformations 39.9
37capillary malformation-arteriovenous malformation9.9
38telangiectasia, hereditary hemorrhagic, type 49.9
39polycythemia vera9.9
40telangiectasia, hereditary hemorrhagic, type 29.9
41fabry disease9.9
42hemophilia b9.9
43malaria9.9
44anorexia nervosa9.9
45pseudoxanthoma elasticum, forme fruste9.9
46coronary artery disease9.9
47cerebral cavernous malformations-19.9
48erythrocytosis, somatic9.9
49telangiectasia, hereditary hemorrhagic, type 19.9
50thrombocytopenia, x-linked9.9

Graphical network of the top 20 diseases related to Cerebral Hemorrhage:



Diseases related to cerebral hemorrhage

Symptoms for Cerebral Hemorrhage

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Drugs & Therapeutics for Cerebral Hemorrhage

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Drug clinical trials:

Search ClinicalTrials for Cerebral Hemorrhage

Search NIH Clinical Center for Cerebral Hemorrhage

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Cerebral Hemorrhage cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cerebral Hemorrhage:
GLP-1 CellBeads
Embryonic/Adult Cultured Cells Related to Cerebral Hemorrhage:
GLP-transfected mesenchymal stem cells, PMIDs: 22985173, 22034462

Genetic Tests for Cerebral Hemorrhage

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Anatomical Context for Cerebral Hemorrhage

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MalaCards organs/tissues related to Cerebral Hemorrhage:

31
Brain, Heart, Neutrophil, T cells, Pituitary

Animal Models for Cerebral Hemorrhage or affiliated genes

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MGI Mouse Phenotypes related to Cerebral Hemorrhage:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0HSPB8, APP, SERPINF2, LOX, CST3
2MP:00053697.4HSPB8, APP, LOX, CST3, AGRN

Publications for Cerebral Hemorrhage

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Articles related to Cerebral Hemorrhage:

(show top 50)    (show all 178)
idTitleAuthorsYear
1
Significance of intraventricular hemorrhage in acute intracerebral hemorrhage: intensive blood pressure reduction in acute cerebral hemorrhage trial results. (25677598)
2015
2
Response to letter regarding article, "defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the national institute of neurological disorders and stroke tissue-type plasminogen activator trials". (25572410)
2015
3
Initial diagnosis of the congenital disorder of glycosylation PMM2-CDG (CDG1a) in a 4-year-old girl after neurosurgical intervention for cerebral hemorrhage. (25192236)
2014
4
Effects of High-Pressure Oxygen Therapy on Brain Tissue Water Content and AQP4 Expression in Rabbits with Cerebral Hemorrhage. (25064222)
2014
5
Association of CVD candidate gene polymorphisms with ischemic stroke and cerebral hemorrhage in Chinese individuals. (25144711)
2014
6
Multiple cerebral hemorrhagic foci from metastases during temozolomide treatment in a patient with corticotroph pituitary carcinoma. (24823463)
2014
7
Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the national institute of neurological disorders and stroke tissue-type plasminogen activator trials. (25096731)
2014
8
Association of variants in KCNK17 gene with ischemic stroke and cerebral hemorrhage in a Chinese population. (25179130)
2014
9
Intravenous immunoglobulin in Henoch-SchAPnlein purpura complicated by cerebral hemorrhage. (22829413)
2013
10
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. (23857095)
2013
11
Cerebral microbleeds (CMBs) - relevance for mechanisms of cerebral hemorrhage--analysis of 24 MRI evaluated patients. (24868257)
2013
12
Diabetic ketoacidosis with cerebral hemorrhage and alpha coma in an adolescent female. (23515102)
2013
13
Cerebral hemorrhage, brain edema, and heme oxygenase-1 expression after experimental traumatic brain injury. (23564109)
2013
14
Fibrinogen polymorphisms associated with sporadic cerebral hemorrhage in a Chinese population. (22386478)
2012
15
Infective endocarditis complicated by fatal cerebral hemorrhage revealing an unrepaired univentricular heart in a 19-year-old woman. (21547931)
2011
16
The clinical significance of S100I^ protein in cerebrospinal fluid and serum from the patients with cerebral hemorrhage]. (21906477)
2011
17
Histopathological analysis of cerebral hemorrhage in systemic lupus erythematosus complicated with antiphospholipid syndrome. (21318307)
2011
18
Association between polymorphism of rs3212855 and rs5515 of KLK1 gene with cerebral hemorrhage in Changsha Han population]. (21200088)
2010
19
Hereditary cerebral hemorrhage with amyloidosis associated with the E693K mutation of APP. (20697050)
2010
20
The potential of capillary birthmarks as a significant marker for capillary malformation-arteriovenous malformation syndrome in children who had nontraumatic cerebral hemorrhage. (21129558)
2010
21
Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)
2009
22
Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion. (17629591)
2009
23
Cerebral vascular accumulation of Dutch-type Abeta42, but not wild-type Abeta42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type. (17628026)
2007
24
Large acute cerebral hemorrhage presenting with pure alexia. (17083996)
2007
25
Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. (15014955)
2004
26
Association between alpha-1-antichymotrypsin gene polymorphism and cerebral hemorrhage]. (12126519)
2002
27
Enhanced Abeta40 deposition was associated with increased Abeta42-43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D). (12480745)
2002
28
Cellular processing of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. (10524281)
1999
29
Cerebral hemorrhage and apoE. (10525983)
1999
30
A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension. (9759612)
1998
31
Microvasculopathy is associated with the number of cerebrovascular lesions in hereditary cerebral hemorrhage with amyloidosis, Dutch type. (9707198)
1998
32
Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D). (9542588)
1998
33
Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. (8644866)
1996
34
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): II--A review of histopathological aspects. (8737927)
1996
35
Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. (7654074)
1995
36
Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology. (7839831)
1994
37
High colloid oncotic therapy for brain edema with cerebral hemorrhage. (7976652)
1994
38
Cerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly. (8336159)
1993
39
Morphology of cerebral plaque-like lesions in hereditary cerebral hemorrhage with amyloidosis (Dutch). (1471474)
1992
40
Progressive dementia, without cerebral hemorrhage, in a patient with hereditary cerebral amyloid angiopathy. (1335860)
1992
41
Acute-phase proteins in stroke: influences of its cause (cerebral hemorrhage or infarction), of the cerebral site of infarction, and of the sex of patients. (1716456)
1991
42
Hemopericardium following cerebral hemorrhage. Report of an autopsy case. (1836300)
1991
43
Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Tc-99m HM-PAO single photon emission computed tomography. (2398939)
1990
44
Diagnosis of cerebral amyloid angiopathy with cerebral hemorrhage by enzyme linked immunosorbent assay (ELISA) of cystatin C in the cerebrospinal fluid]. (2364630)
1990
45
Hereditary cerebral hemorrhage. Dementia with cystatin C amyloidosis]. (2320403)
1990
46
A case of acute poststreptococcal glomerulonephritis associated with cerebral hemorrhage. (3694896)
1987
47
Abnormal metabolism of gamma-trace alkaline microprotein. The basic defect in hereditary cerebral hemorrhage with amyloidosis. (6390199)
1984
48
VA clinical pathological conference: cerebral hemorrhage associated with malignant nephrosclerosis and cardiac hypertrophy. (13013101)
1952
49
Massive cerebral hemorrhage following heparin therapy in subacute bacterial endocarditis; report of two cases with a review of the literature. (15394693)
1949
50
Changes in cerebral veins in hypertensive brain disease and their relation to cerebral hemorrhage; clinical pathologic study. (21012278)
1945

Variations for Cerebral Hemorrhage

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Expression for genes affiliated with Cerebral Hemorrhage

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Search GEO for disease gene expression data for Cerebral Hemorrhage.

Pathways for genes affiliated with Cerebral Hemorrhage

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Pathways related to Cerebral Hemorrhage according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CST3, APP
2
Show member pathways
9.3SERPINF2, APP

Compounds for genes affiliated with Cerebral Hemorrhage

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Compounds related to Cerebral Hemorrhage according to GeneCards Suite gene sharing:

(show all 25)
idCompoundScoreTop Affiliating Genes
1vitamin b6439.9LOX, CST3
2leupeptin439.8APP, CST3
3aprotinin43 1210.8SERPINF2, CST3
4captopril43 59 49 28 1213.7CST3, APP
56-hydroxydopamine439.7APP, CST3
6Hydrogen peroxide249.6LOX, APP
7ndga439.6LOX, APP
8gold439.6LOX, CST3
9ibuprofen43 28 49 24 1213.5APP, LOX
10homocysteine43 2410.5CST3, LOX
11urea43 24 1211.4SERPINF2, CST3, LOX
12sodium dodecylsulfate439.4APP, SERPINF2
13kininogen439.3SERPINF2, CST3, APP
14glycosaminoglycan439.2AGRN, LOX
15glutamine439.2APP, CST3, SERPINF2
16sialic acid439.1SERPINF2, CST3, AGRN
17cholesterol43 28 24 1212.1CST3, SERPINF2, APP
18matrigel439.1CST3, LOX, AGRN
19polysaccharide439.1AGRN, CST3, SERPINF2
20dexamethasone43 49 28 1212.0CST3, LOX, APP
21vegf438.8SERPINF2, LOX, APP, CST3
22heparin43 28 24 1211.7APP, AGRN, SERPINF2
23arginine438.7CST3, SERPINF2, APP
24serine438.1SERPINF2, APP, HSPB6, CST3, AGRN
25lipid438.0SERPINF2, APP, LOX, CST3, AGRN

GO Terms for genes affiliated with Cerebral Hemorrhage

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Cellular components related to Cerebral Hemorrhage according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.3SERPINF2, APP
2cell surfaceGO:00099868.2AGRN, SERPINF2, APP
3extracellular spaceGO:00056158.1SERPINF2, LOX, CST3, AGRN
4extracellular regionGO:00055767.6AGRN, CST3, LOX, SERPINF2, APP

Biological processes related to Cerebral Hemorrhage according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to stressGO:00069509.5HSPB6, HSPB8
2collagen fibril organizationGO:00301999.4SERPINF2, LOX
3negative regulation of endopeptidase activityGO:00109519.1CST3, SERPINF2, APP
4platelet degranulationGO:00025769.0SERPINF2, APP
5extracellular matrix organizationGO:00301988.6AGRN, LOX, APP
6positive regulation of transcription from RNA polymerase II promoterGO:00459448.5AGRN, SERPINF2, APP

Molecular functions related to Cerebral Hemorrhage according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.5SERPINF2, CST3
2serine-type endopeptidase inhibitor activityGO:00048679.3APP, SERPINF2
3protease bindingGO:00020209.3SERPINF2, CST3
4protein bindingGO:00055156.7HSPB8, HSPB6, APP, SERPINF2, LOX, CST3

Products for genes affiliated with Cerebral Hemorrhage

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  • Antibodies
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Sources for Cerebral Hemorrhage

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet