MCID: CRB090
MIFTS: 43

Cerebral Hypoxia malady

Neuronal diseases category

Aliases & Classifications for Cerebral Hypoxia

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Sources:
43NINDS, 44Novoseek, 61UMLS
See all sources

Aliases & Descriptions for Cerebral Hypoxia:

Name: Cerebral Hypoxia 43 44
 
Brain Hypoxia 61


Classifications:



Summaries for Cerebral Hypoxia

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NINDS:43 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

MalaCards based summary: Cerebral Hypoxia, also known as brain hypoxia, is related to ischemia and brain ischemia. An important gene associated with Cerebral Hypoxia is CASP9 (caspase 9, apoptosis-related cysteine peptidase), and among its related pathways are Amyotrophic lateral sclerosis (ALS) and p75(NTR)-mediated signaling. The compounds sulindac sulfide and cd 437 have been mentioned in the context of this disorder. Affiliated tissues include brain, spleen and cortex, and related mouse phenotypes are other and limbs/digits/tail.

Wikipedia:64 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen) specifically involving the brain; when... more...

Related Diseases for Cerebral Hypoxia

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Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.1BMP7, PLAT, CASP3, CASP9, NOS1, CREB1
2brain ischemia30.1NOS1, APP, PLAT
3vascular disease29.9FOS, CASP3, CASP9, CREB1, NOS1
4hypoxia11.2
5cerebritis11.2
6neuronitis10.6
7brain injury10.5
8anoxia10.4
9traumatic brain injury10.4
10neurotic disorder10.3NOS1, CREB1
11ewing sarcoma10.3NOS1, CASP3
12coffin-lowry syndrome10.2FOS, CREB1
13myocardial infarction10.2PLAT, NOS1
14macular degeneration, age-related, 110.2PLAT
15prion disease10.2APP, CREB1, NOS1
16cerebral artery occlusion10.2
17hemorrhage, intracerebral10.2PLAT, APP
18eye disease10.1FOS, CASP3
19endometrial cancer10.1CASP9, CREB1, FOS
20thyroid cancer, anaplastic10.1BMP7, CASP3
21parkinson disease, late-onset10.1APP, NOS1, CASP9, CASP3
22huntington disease10.1NOS1, CREB1, APP, CASP3
23hyperglycemia10.1IGF1, CREB1, CASP3
24kidney disease10.1CASP3, FOS, BMP7
25mental retardation10.0CREB1, FOS, APP
26viral infectious disease10.0ITGAV, NOS1, CREB1, CASP9
27t-cell leukemia10.0FOS, CASP9, CREB1, CASP3
28factor v leiden thrombophilia10.0CREB1, PLAT, NOS1
29myeloid leukemia10.0FOS, CASP9, CREB1, CASP3
30sudden infant death syndrome10.0
31moyamoya disease10.0
32migraine10.0
33pulmonary edema10.0
34dementia10.0
35dystonia10.0
36focal dystonia10.0
37intracranial hypertension10.0
38lactic acidosis10.0
39laryngitis10.0
40wallerian degeneration10.0
41myoclonus10.0
42syncope10.0
43endotheliitis10.0
44retinoblastoma10.0FOS, CASP3, CASP9, CREB1
45toxic encephalopathy10.0APP, FOS, CASP3, CREB1
46amyotrophic lateral sclerosis 110.0CASP3, APP, NOS1, IGF1
47b-cell lymphomas10.0CASP9, ITGB1, CASP3
48alzheimer disease10.0CASP3, APP, NOS1, CREB1, CASP9
49down syndrome10.0APP, ITGB1, CREB1
50adenoma9.9ITGAV, IGF1, CREB1, NOS1

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to cerebral hypoxia

Symptoms for Cerebral Hypoxia

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Drugs & Therapeutics for Cerebral Hypoxia

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Drug clinical trials:

Search ClinicalTrials for Cerebral Hypoxia

Search NIH Clinical Center for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

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Anatomical Context for Cerebral Hypoxia

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MalaCards organs/tissues related to Cerebral Hypoxia:

31
Brain, Spleen, Cortex, Lung, Monocytes, Endothelial

Animal Models for Cerebral Hypoxia or affiliated genes

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MGI Mouse Phenotypes related to Cerebral Hypoxia:

35 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.3NOS1, ITGB1, APP
2MP:00053718.2FOS, BMP7, ITGB1, IGF1
3MP:00053917.9NOS1, CASP3, PLAT, BMP7, ITGB1, FOS
4MP:00053777.8CASP3, IGF1, PLAT, BMP7, ITGB1, FOS
5MP:00107717.6CAMK4, APP, IGF1, ITGB1, BMP7, FOS
6MP:00053817.6CASP3, ITGB1, ITGAV, BMP7, NOS1, PLAT
7MP:00053807.6FOS, ITGB1, ITGAV, BMP7, CASP9, CREB1
8MP:00053677.5ITGAV, IGF1, BMP7, CASP3, NOS1, ITGB1
9MP:00053887.5CREB1, CASP9, CASP3, PLAT, BMP7, ITGB1
10MP:00028737.4IGF1, APP, NOS1, FOS, ITGB1, BMP7
11MP:00053827.3BMP7, ITGAV, ITGB1, FOS, CASP3, CASP9
12MP:00053907.0CAMK4, NOS1, PLAT, BMP7, ITGB1, CREB1
13MP:00053696.9IGF1, APP, ITGB1, PLAT, CASP3, CREB1
14MP:00053866.8FOS, CREB1, NOS1, PLAT, ITGAV, ITGB1
15MP:00053796.7IGF1, NOS1, CREB1, CAMK4, CASP3, BMP7
16MP:00053896.7APP, ITGB1, PLAT, CASP3, CAMK4, FOS
17MP:00053856.6ITGAV, BMP7, NOS1, CREB1, CASP3, CASP9
18MP:00053976.6FOS, ITGB1, CAMK4, CASP3, CASP9, ITGAV
19MP:00053766.2ITGAV, PLAT, NOS1, ITGB1, FOS, APP
20MP:00053846.0IGF1, APP, FOS, ITGAV, PLAT, CASP3
21MP:00053875.9BMP7, IGF1, APP, NOS1, CAMK4, CASP9
22MP:00036315.6PLAT, IGF1, APP, FOS, ITGB1, ITGAV
23MP:00053785.6NOS1, CREB1, CAMK4, CASP9, IGF1, FOS
24MP:00107685.6APP, IGF1, PLAT, FOS, ITGB1, ITGAV

Publications for Cerebral Hypoxia

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Articles related to Cerebral Hypoxia:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
Cerebral hypoxia-ischemia increases toll-like receptor 2 and 4 expression in the hippocampus of neonatal rats. (25530127)
2014
2
Therapeutic benefits of delayed lithium administration in the neonatal rat after cerebral hypoxia-ischemia. (25211332)
2014
3
Targeted drug delivery to treat pain and cerebral hypoxia. (23343976)
2013
4
Cognitive decline in moyamoya: influence of chronic cerebral hypoxia, history of stroke, or comorbid conditions? (22171927)
2012
5
Experimental evidence of the potential use of erythropoietin by intranasal administration as a neuroprotective agent in cerebral hypoxia. (21756166)
2011
6
Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia-ischemia. (19782128)
2010
7
Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia. (19168722)
2009
8
Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia. (19628795)
2009
9
Mild cerebral hypoxia-ischemia produces a sub-acute transient inflammatory response that is less selective and prolonged after a substantial insult. (19631731)
2009
10
Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms. (19815706)
2009
11
"Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets. (17475224)
2007
12
Plasminogen activators contribute to impairment of hypercapnic and hypotensive cerebrovasodilation after cerebral hypoxia/ischemia in the newborn pig. (16141421)
2005
13
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. (15592434)
2005
14
A novel role for an established player: anemia drug erythropoietin for the treatment of cerebral hypoxia/ischemia. (15294194)
2004
15
Extracellular superoxide concentration increases following cerebral hypoxia but does not affect cerebral blood flow. (15245758)
2004
16
Delayed postischemic hypothermia improves long-term behavioral outcome after cerebral hypoxia-ischemia in neonatal rats. (11861942)
2002
17
Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia. (11275647)
2001
18
Detection and treatment of cerebral hypoxia key to avoiding intraoperative brain injuries. (12578096)
2000
19
Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats. (11154758)
2000
20
Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury. (11154759)
2000
21
Prevention of both T2- and diffusion-weighted increases in image intensity during cerebral hypoxia-ischemia in infant rats pretreated with dexamethasone. (10204774)
1999
22
Magnetic resonance imaging during cerebral hypoxia-ischemia: T2 increases in 2-week-old but not 4-week-old rats. (10022586)
1999
23
Cerebral hypoxia after cardiopulmonary resuscitation. (10073537)
1999
24
Metabolite changes in neonatal rat brain during and after cerebral hypoxia-ischemia: a magnetic resonance spectroscopic imaging study. (10195327)
1999
25
Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet. (9578400)
1998
26
Lipid free radical generation and brain cell membrane alteration following nitric oxide synthase inhibition during cerebral hypoxia in the newborn piglet. (9326283)
1997
27
Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats. (9089690)
1997
28
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists. (9364488)
1997
29
Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study. (9205806)
1997
30
Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. (8554576)
1995
31
DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat. (7614012)
1995
32
Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia. (8053660)
1994
33
Delayed-onset focal dystonia after diffuse cerebral hypoxia--two case reports. (8179837)
1993
34
Brain metabolism and blood flow in acute cerebral hypoxia studied by NMR spectroscopy and hydrogen clearance. (1550710)
1992
35
Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage. (1971436)
1990
36
Protective effect of KB-2796, a new calcium antagonist, in cerebral hypoxia and ischemia. (2241412)
1990
37
Cerebral hypoxia-ischemia in immature rats: methodological considerations. (3342854)
1988
38
Visual defects in children after cerebral hypoxia. (6525237)
1984
39
Early computed tomographic abnormalities following profound cerebral hypoxia. (6477220)
1984
40
The role of dilantin in the prevention of pulmonary edema associated with cerebral hypoxia. (7083868)
1982
41
Gray matter enhancement: a computerized tomographic sign of cerebral hypoxia. (7191063)
1980
42
Hyperventilation-induced cerebral hypoxia. (6774644)
1980
43
The morphologic consequences of cerebral hypoxia. (517287)
1979
44
Immediate restoration of central nervous system autonomic cardiopulmonary control: survival of "lethal" cerebral hypoxia by treatment with prostaglandin Bx. (401242)
1978
45
Effect of gamma-oxybutyric acid on the subcellular reaction to cerebral hypoxia [proceedings]. (885430)
1977
46
Histopathologic and ultrastructural study in infantile encephalopathy by obstetrical cerebral hypoxia. (987614)
1976
47
The CSF lactate-pyruvate ratio in cerebral hypoxia. (5638919)
1968
48
Cardiac factors in cerebral hypoxia. (14020142)
1963
49
Action of cerebral hypoxia on the pulmonary arterial pressure of the dog (14437309)
1960
50
Cerebral hypoxia: aetiology and treatment. (13293396)
1956

Variations for Cerebral Hypoxia

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Expression for genes affiliated with Cerebral Hypoxia

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Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for genes affiliated with Cerebral Hypoxia

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Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.5NOS1, CASP9, CASP3
2
Show member pathways
9.5CASP9, CASP3, APP
39.2NOS1, CAMK4, APP, CREB1
4
Show member pathways
Alzheimers Disease36
9.2NOS1, CASP9, CASP3, APP
59.1FOS, CASP3, CASP9, CAMK4
6
Show member pathways
Calcium Regulation in the Cardiac Cell36
9.1CREB1, FOS, CAMK4, NOS1
79.1CASP3, FOS, CASP9, CREB1
8
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1CASP3, CASP9, CREB1, FOS
9
Show member pathways
9.1FOS, CASP3, CASP9, CREB1
109.1FOS, CREB1, CAMK4, CASP3
11
Show member pathways
DNA damage response36
8.9CREB1, IGF1, CASP3, CASP9
128.9IGF1, PLAT, BMP7
13
Show member pathways
8.9ITGB1, FOS, CASP9, CASP3
14
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades59
Caspase cascade in apoptosis36
8.9CASP9, CASP3, APP, IGF1
15
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
8.9ITGB1, FOS, CREB1, CASP3
16
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.8IGF1, FOS, CASP9, CASP3
17
Show member pathways
8.8IGF1, FOS, CASP3, CAMK4
18
Show member pathways
8.8CAMK4, CASP9, PLAT, CREB1, CASP3
19
Show member pathways
8.7CASP3, CREB1, CASP9, FOS, APP
20
Show member pathways
8.7BMP7, ITGAV, ITGB1
21
Show member pathways
8.7FOS, BMP7, CAMK4, NOS1, CREB1
22
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells36
8.6ITGAV, FOS, CASP9, CREB1
23
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
8.6ITGB1, IGF1, FOS, CREB1
248.6IGF1, CREB1, CASP9, CASP3, APP
25
Show member pathways
8.5CASP9, ITGB1, ITGAV, CASP3
26
Show member pathways
8.4ITGAV, CASP9, FOS, ITGB1
27
Show member pathways
8.4NOS1, CREB1, CAMK4, CASP3, FOS, APP
28
Show member pathways
8.4ITGAV, BMP7, CASP3, ITGB1
29
Show member pathways
8.4FOS, CASP9, CASP3, IGF1, BMP7
30
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
8.4ITGB1, PLAT, FOS, IGF1
31
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.3FOS, CASP3, ITGB1, CREB1, CASP9, CAMK4
32
Show member pathways
Signal transduction PTEN pathway59
8.3FOS, CASP3, CASP9, ITGB1, IGF1
338.2IGF1, ITGB1, ITGAV, CASP3
34
Show member pathways
8.1CAMK4, FOS, BMP7, CASP3, NOS1, CASP9
35
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
8.1ITGAV, CAMK4, ITGB1, FOS, CREB1
36
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.1ITGB1, ITGAV, FOS, IGF1
37
Show member pathways
8.1IGF1, ITGAV, ITGB1, FOS
38
Show member pathways
8.0ITGAV, CREB1, CASP3, ITGB1, FOS
397.9IGF1, ITGB1, ITGAV, CREB1, CASP9
40
Show member pathways
7.8CAMK4, PLAT, CASP9, CASP3, CREB1, IGF1
41
Show member pathways
7.7ITGB1, ITGAV, CASP9, CAMK4, CREB1, IGF1
42
Show member pathways
7.5CREB1, CAMK4, BMP7, ITGAV, ITGB1, IGF1
437.4IGF1, FOS, ITGAV, CASP3, CASP9, ITGB1
44
Show member pathways
7.3BMP7, FOS, ITGB1, ITGAV, CREB1, IGF1
45
Show member pathways
7.3APP, ITGB1, ITGAV, NOS1, IGF1, PLAT
46
Show member pathways
7.1IGF1, CREB1, FOS, ITGB1, ITGAV, BMP7
47
Show member pathways
6.7CAMK4, CASP3, CREB1, NOS1, CASP9, BMP7
48
Show member pathways
6.7CREB1, CASP3, IGF1, CASP9, FOS, ITGB1
49
Show member pathways
6.7FOS, ITGB1, ITGAV, CASP3, CASP9, CREB1
50
Show member pathways
6.4CASP3, BMP7, CASP9, CREB1, ITGAV, IGF1

Compounds for genes affiliated with Cerebral Hypoxia

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Compounds related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50)    (show all 135)
idCompoundScoreTop Affiliating Genes
1sulindac sulfide449.8CASP9, APP, CASP3
2cd 437449.6FOS, CASP3, CASP9
315-deoxy-delta-12,14-prostaglandin j2449.5CASP9, FOS, CASP3, CREB1
4pdtc449.5FOS, CASP3, NOS1, CASP9
5ethidium bromide449.5CASP3, CASP9, PLAT
6s-nitroso-n-acetylpenicillamine449.4NOS1, CASP9, CASP3
76-hydroxydopamine449.4APP, CASP3, FOS, CREB1
8corticosterone44 60 2411.4NOS1, CREB1, FOS, APP
9egcg449.4CASP3, APP, CASP9, FOS
10carbachol44 28 1111.4CREB1, APP, FOS, NOS1
11thapsigargin44 6010.3CREB1, CASP9, CASP3, APP
12lactacystin449.3APP, NOS1, CASP9, CREB1, CASP3
135-hydroxytryptamine449.3CREB1, NOS1, APP, PLAT
14simvastatin44 50 60 28 24 1114.3CASP9, CASP3, APP, PLAT
15sp 60012544 6010.3CASP9, CASP3, ITGB1, FOS
163-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.2CASP3, CASP9, APP
17isoproterenol44 1110.2NOS1, CREB1, PLAT, APP
18retinoid449.2CREB1, CAMK4, CASP9, FOS
194-hydroxynonenal44 2410.2CASP9, APP, FOS, CREB1, CASP3
20chelerythrine449.2IGF1, FOS, CREB1
21curcumin449.1CASP9, APP, CREB1, CASP3, FOS
22butyrate449.1CREB1, CASP9, CASP3, FOS, APP
23pge2449.0BMP7, CASP9, CREB1, NOS1, FOS
24titanium449.0ITGAV, ITGB1, BMP7
25rapamycin448.9CREB1, CASP9, IGF1, CASP3, BMP7
26nmda44 289.9FOS, CASP9, CAMK4, CREB1, APP, NOS1
27ly294002448.8FOS, CREB1, CASP9, CASP3, IGF1
28h2o2448.8CASP9, CREB1, FOS, NOS1, CASP3, APP
29dopamine44 28 24 1111.7IGF1, NOS1, FOS, APP, CREB1
30glutamine448.7NOS1, CREB1, ITGB1, IGF1, APP
31gnrh448.6IGF1, CREB1, FOS, APP, PLAT
32glutamate448.6CREB1, NOS1, CASP9, FOS, APP, PLAT
33calcitriol44 60 24 1111.6BMP7, IGF1, FOS, ITGB1, CREB1
34cyclosporin a44 28 6010.5CASP9, PLAT, ITGB1, NOS1, APP, CASP3
35adenylate448.5NOS1, CREB1, PLAT, FOS, APP
36creatinine448.4APP, IGF1, NOS1, PLAT, BMP7
37pd 98,059448.4IGF1, FOS, CREB1, CASP9, CASP3, ITGB1
38wortmannin448.4ITGB1, CASP3, CASP9, IGF1, CREB1, FOS
39phosphatidylinositol448.3ITGB1, FOS, CREB1, IGF1, CASP9, CASP3
40cysteine448.2NOS1, CASP3, PLAT, APP, ITGB1, CREB1
41estrogen448.1IGF1, FOS, ITGB1, NOS1, BMP7, CREB1
42sb 20358044 609.1NOS1, CASP3, CASP9, ITGB1, FOS, IGF1
43genistein44 28 60 1 24 1113.1ITGB1, FOS, IGF1, CASP9, CASP3, CREB1
44actinomycin d448.0APP, CASP9, CASP3, PLAT, FOS, IGF1
45dexamethasone44 50 28 1110.6NOS1, BMP7, CASP9, CREB1, APP, IGF1
46tyrosine447.2BMP7, ITGAV, CAMK4, CREB1, ITGB1, FOS
47cycloheximide447.2CREB1, FOS, NOS1, IGF1, ITGB1, BMP7
48retinoic acid44 247.8NOS1, FOS, CASP9, CASP3, PLAT, BMP7
49vegf446.7CASP3, BMP7, ITGAV, FOS, ITGB1, APP
50serine446.5FOS, NOS1, CREB1, CAMK4, CASP9, IGF1

GO Terms for genes affiliated with Cerebral Hypoxia

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Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synapseGO:00452029.3APP, PLAT, NOS1
2integrin complexGO:00083059.0ITGAV, ITGB1
3cell surfaceGO:00099868.3PLAT, ITGAV, ITGB1, APP
4cytosolGO:00058298.1APP, FOS, CASP3, CASP9, CAMK4, NOS1
5extracellular vesicular exosomeGO:00700628.0CAMK4, PLAT, ITGAV, ITGB1, APP

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1glial cell apoptotic processGO:003434910.2CASP3, CASP9
2activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:000863510.1CASP9, CASP3
3platelet formationGO:003022010.1CASP9, CASP3
4positive regulation of osteoclast differentiationGO:00456729.9FOS, CREB1
5Type I pneumocyte differentiationGO:00605099.8CREB1, IGF1
6SMAD protein signal transductionGO:00603959.8FOS, BMP7
7fibroblast growth factor receptor signaling pathwayGO:00085439.8CASP9, CAMK4, CREB1
8neuron apoptotic processGO:00514029.8CASP3, APP
9epidermal growth factor receptor signaling pathwayGO:00071739.7CAMK4, CASP9, CREB1
10Fc-epsilon receptor signaling pathwayGO:00380959.6FOS, CREB1, CASP9
11dendrite developmentGO:00163589.6APP, BMP7
12neurotrophin TRK receptor signaling pathwayGO:00480119.6CREB1, CASP9, CASP3, CAMK4
13regulation of multicellular organism growthGO:00400149.5APP, IGF1
14phosphatidylinositol-mediated signalingGO:00480159.5CREB1, CASP9, IGF1
15negative regulation of neuron differentiationGO:00456659.5APP, BMP7, ITGB1
16branching morphogenesis of an epithelial tubeGO:00487549.4BMP7, IGF1
17positive regulation of apoptotic processGO:00430659.2CASP3, ITGB1, BMP7, CASP9
18innate immune responseGO:00450879.1CREB1, APP, CAMK4, FOS, CASP9
19extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.0IGF1, ITGAV, CASP3
20positive regulation of transcription, DNA-templatedGO:00458938.7IGF1, CREB1, CAMK4, FOS, BMP7
21negative regulation of extrinsic apoptotic signaling pathwayGO:020012378.7IGF1, ITGAV
22axon guidanceGO:00074118.7ITGB1, BMP7, CREB1, ITGAV
23extracellular matrix organizationGO:00301988.4APP, ITGB1, ITGAV, BMP7, CASP3
24positive regulation of transcription from RNA polymerase II promoterGO:00459448.3APP, CREB1, BMP7, FOS, NOS1, IGF1
25blood coagulationGO:00075967.7ITGAV, IGF1, APP, ITGB1, PLAT, NOS1

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:00016189.1ITGAV, ITGB1
2protein bindingGO:00055155.2NOS1, IGF1, APP, FOS, ITGB1, ITGAV

Sources for Cerebral Hypoxia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet