MCID: CRB090
MIFTS: 45

Cerebral Hypoxia malady

Summaries for Cerebral Hypoxia

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

MalaCards: Cerebral Hypoxia is related to brain ischemia and vascular disease. An important gene associated with Cerebral Hypoxia is CASP9 (caspase 9, apoptosis-related cysteine peptidase), and among its related pathways are CaMK IV-mediated phosphorylation of CREB and Apoptotic factor-mediated response. The compounds butyrate and gnrh have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and spleen, and related mouse phenotypes are vision/eye and renal/urinary system.

Wikipedia:64 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen) specifically involving the brain; when... more...

Aliases & Classifications for Cerebral Hypoxia

Sources:
44NINDS, 45Novoseek
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Aliases & Descriptions:

cerebral hypoxia 44 45


Related Diseases for Cerebral Hypoxia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1brain ischemia30.8NOS1, PLAT, APP
2vascular disease29.9CASP3, CASP9, FOS, CREB1, NOS1
3hypoxia11.2
4anoxia10.4
5brain injury10.4
6traumatic brain injury10.3
7transient cerebral ischemia10.3
8cerebral artery occlusion10.1
9moyamoya disease10.0
10pulmonary edema10.0
11sudden infant death syndrome10.0
12wernicke encephalopathy10.0
13focal dystonia10.0
14wallerian degeneration10.0
15myoclonus10.0
16syncope10.0
17memory impairment10.0
18multiple sclerosis10.0CASP9
19chondrosarcoma10.0BMP7
20tetanus10.0APP
21choriocarcinoma10.0CREB1
22galactosemia10.0IGF1
23multiple myeloma10.0IGF1
24encephalitis10.0APP
25anorexia nervosa10.0IGF1
26uremia10.0IGF1
27oral cancer10.0CASP3, CASP9
28pneumonia10.0NOS1, CASP9
29medulloblastoma10.0CASP9, CASP3
30malignant glioma10.0CASP9, CASP3
31cervical cancer10.0CASP9, CASP3
32nephrotic syndrome10.0ITGB1
33neuroepithelioma10.0NOS1, CASP3
34infertility10.0ITGB1, CASP9
35sarcoma10.0ITGB1, CASP9
36acute leukemia10.0CREB1
37endometriosis10.0ITGB1, CASP9
38dementia10.0NOS1, APP
39deficiency anemia10.0NOS1
40influenza10.0NOS1, CREB1
41hyperhomocysteinemia10.0PLAT
42pituitary adenoma10.0IGF1, CREB1
43dopa-responsive cervical dystonia10.0CREB1, NOS1
44lung cancer10.0IGF1, APP
45hepatitis b10.0FOS
46coronary heart disease10.0PLAT
47synovitis10.0ITGB1
48acute myocardial infarction10.0PLAT, NOS1
49myocardial infarction10.0PLAT, NOS1
50stroke, ischemic10.0BMP7, PLAT

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to cerebral hypoxia

Clinical Features for Cerebral Hypoxia

Drugs & Therapeutics for Cerebral Hypoxia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cerebral Hypoxia

Drug clinical trials:

Search ClinicalTrials for Cerebral Hypoxia

Search NIH Clinical Center for Cerebral Hypoxia

Search CenterWatch for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

Anatomical Context for Cerebral Hypoxia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cerebral Hypoxia:

33
Brain, Lung, Spleen, Whole blood, Cortex, Smooth muscle, T cells, Endothelial, Fetal brain, Fetal lung

Animal Models for Cerebral Hypoxia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cerebral Hypoxia:

37 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.3NOS1, PLAT, BMP7
2MP:00053679.0BMP7, ITGAV, NOS1
3MP:00053809.0ITGB1, BMP7, CASP9
4MP:00053778.8FOS, BMP7, ITGB1
5MP:00053898.7CASP3, CAMK4, APP, CREB1, ITGB1
6MP:00053798.1CASP3, CAMK4, FOS, BMP7, CREB1, ITGB1
7MP:00036317.9CASP3, CAMK4, CASP9, FOS, BMP7, CREB1
8MP:00107717.8CASP3, CAMK4, APP, FOS, BMP7, ITGB1
9MP:00053887.8CASP3, CASP9, BMP7, CREB1, ITGB1, IGF1
10MP:00053697.4CASP3, APP, CREB1, ITGAV, ITGB1, IGF1
11MP:00053767.3CAMK4, APP, CREB1, ITGAV, ITGB1, IGF1
12MP:00053907.3CASP3, CAMK4, BMP7, CREB1, ITGB1, IGF1
13MP:00053827.2CASP3, CASP9, FOS, BMP7, ITGAV, ITGB1
14MP:00053817.2CASP3, BMP7, ITGAV, ITGB1, PLAT, NOS1
15MP:00028737.1CAMK4, APP, FOS, BMP7, CREB1, ITGB1
16MP:00053856.7CASP3, CASP9, BMP7, CREB1, ITGAV, ITGB1
17MP:00053866.6CASP3, CAMK4, APP, FOS, CREB1, ITGAV
18MP:00053976.6CASP3, CAMK4, CASP9, FOS, ITGAV, ITGB1
19MP:00053846.0CASP3, CAMK4, CASP9, APP, FOS, CREB1
20MP:00053875.6NOS1, CASP3, CAMK4, CASP9, APP, FOS
21MP:00053785.6FOS, APP, CASP9, CAMK4, CASP3, BMP7
22MP:00107685.5CASP3, CAMK4, CASP9, APP, FOS, BMP7

Publications for Cerebral Hypoxia

Sources:
51PubMed
See all sources

Articles related to Cerebral Hypoxia:

(show top 50)    (show all 292)
idTitleAuthorsYear
1
Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia. (24117382)
2014
2
Cerebral hypoxia in a cat following pharyngoscopy involving use of a mouth gag. (22924887)
2013
3
Experimental evidence of the potential use of erythropoietin by intranasal administration as a neuroprotective agent in cerebral hypoxia. (21756166)
2011
4
Brain hypoxia is associated with short-term outcome after severe traumatic brain injury independently of intracranial hypertension and low cerebral perfusion pressure. (21673608)
2011
5
Hypoxia induces T Helper 17 cell upregulation in cultured peripheral blood mononuclear cells from chronic stage patients of severe cerebral infarction. (21204953)
2011
6
Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia-ischemia. (19782128)
2010
7
The effects of hypoxia on the ERG in paediatric cerebral malaria. (19557018)
2010
8
PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia. (20435843)
2010
9
Mechanism of post-translational modification by tyrosine phosphorylation of apoptotic proteins during hypoxia in the cerebral cortex of newborn piglets. (19597709)
2010
10
Nitric oxide pros and cons: The role of L-arginine, a nitric oxide precursor, and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat. (20637840)
2010
11
Mild cerebral hypoxia-ischemia produces a sub-acute transient inflammatory response that is less selective and prolonged after a substantial insult. (19631731)
2009
12
Cerebral hypoxia-ischemia: focus on the use of magnetic resonance imaging and spectroscopy in research on animals. (19428791)
2009
13
The time window of intermittent hypoxia intervention after middle cerebral artery occlusion. (19175189)
2008
14
Adrenomedullin expression is up-regulated by acute hypobaric hypoxia in the cerebral cortex of the adult rat. (18371176)
2008
15
Differential expression of apoptotic proteins following hypoxia-induced CREB phosphorylation in the cerebral cortex of newborn piglets. (17401658)
2007
16
Mechanism of caspase-3 activation during hypoxia in the cerebral cortex of newborn piglets. (17553617)
2007
17
Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study. (17033692)
2007
18
Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain. (17123706)
2007
19
Nitric oxide-mediated mechanism of neuronal nitric oxide synthase and inducible nitric oxide synthase expression during hypoxia in the cerebral cortex of newborn piglets. (16581191)
2006
20
IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal rat. (16259966)
2005
21
Diffusion-weighted MRI during early global cerebral hypoxia: a predictor for clinical outcome? (15527448)
2004
22
Cerebral hypoxia in severely brain-injured patients is associated with admission Glasgow Coma Scale score, computed tomographic severity, cerebral perfusion pressure, and survival. (15128117)
2004
23
Effects of alpha-phenyl-N-tert-butyl nitrone (PBN)on brain cell membrane function and energy metabolism during transient global cerebral hypoxia-ischemia and reoxygenation-reperfusion in newborn piglets. (15201509)
2004
24
Metabolic changes during impending and manifest cerebral hypoxia in traumatic brain injury. (14579900)
2003
25
Neonatal cerebral hypoxia-ischemia causes lateralized memory impairments in the adult rat. (12738060)
2003
26
Protection of striatal neurons by joint blockade of D1 and D2 receptor subtypes in an in vitro model of cerebral hypoxia. (12093100)
2002
27
Expression of Bax and Bcl-2 proteins during hypoxia in cerebral cortical neuronal nuclei of newborn piglets: effect of administration of magnesium sulfate. (11368946)
2001
28
Hydrogen peroxide production in leukocytes during cerebral hypoxia and reoxygenation with 100% or 21% oxygen in newborn piglets. (11385146)
2001
29
Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats. (11154758)
2000
30
Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury. (11154759)
2000
31
Measuring the accentuation of the brain damage that arises from perinatal cerebral hypoxia-ischemia. (9303218)
1997
32
Cerebral hypoxia during cardiopulmonary bypass: a magnetic resonance imaging study. (9307459)
1997
33
Loss of cerebral pressure autoregulation and vasoreactivity to carbon dioxide after cerebral hypoxia. (8669662)
1996
34
Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia. (8053660)
1994
35
Delayed-onset focal dystonia after diffuse cerebral hypoxia--two case reports. (8179837)
1993
36
Potential new therapies for perinatal cerebral hypoxia-ischemia. (8102949)
1993
37
On-line monitoring of global cerebral hypoxia in acute brain injury. Relationship to intracranial hypertension. (8331405)
1993
38
The potential of near infra-red spectroscopy for detection of fetal cerebral hypoxia. (1667101)
1991
39
Cerebral hypoxia: some new approaches and unanswered questions. (1974918)
1990
40
Elevated levels of hypoxanthine in vitreous humor indicate prolonged cerebral hypoxia in victims of sudden infant death syndrome. (3174318)
1988
41
Taurine improves the recovery of neuronal function following cerebral hypoxia: an in vitro study. (3586851)
1987
42
Early computed tomographic abnormalities following profound cerebral hypoxia. (6477220)
1984
43
Experimental cerebral hypoxia and ischaemia in cats. (290154)
1979
44
Protective effects of combinations of hypothermia and barbiturates in cerebral hypoxia in the rat. (686437)
1978
45
Shock, cerebral hypoxia, and pulmonary vascular control: the centrineurogenic etiology of the respiratory distress syndrome. (4199642)
1973
46
Elimination of autoregulation during arterial and cerebral hypoxia. (5707559)
1968
47
Electrographic reflections of cerebral hypoxia. (13705139)
1961
48
Action of cerebral hypoxia on the pulmonary arterial pressure of the dog (14437309)
1960
49
Hyperventilation with oxygen-a possible cause of cerebral hypoxia. (13835570)
1960
50
Effect of isolated cerebral hypoxia and hypercapnia on sodium excretion. (13244630)
1955

Genetic Variations for Cerebral Hypoxia

Expression for genes affiliated with Cerebral Hypoxia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for genes affiliated with Cerebral Hypoxia

Sources:
54Reactome, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 4Cell Signaling Technology, 56SinoBiological, 12EMD Millipore, 53R&D Systems, 60Tocris Bioscience
See all sources

Pathways related to Cerebral Hypoxia according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9CREB1, CAMK4
2
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9.9CASP9, CASP3
3
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9.7ITGB1
4
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9.5NOS1, CASP9, CASP3
59.5CASP3, CASP9, APP
6
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9.4CAMK4, IGF1, CREB1
7
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9.3CASP3, CASP9, FOS
89.2CAMK4, APP, CREB1, NOS1
99.1PLAT, IGF1, BMP7
109.1FOS, CASP9, CAMK4, CASP3
11
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9.0NOS1, CREB1, FOS, CAMK4
12
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9.0IGF1, CREB1, CASP9, CASP3
13
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9.0CREB1, FOS, CASP9, CASP3
14
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9.0CASP9, CASP3, FOS, CREB1
159.0CAMK4, CREB1, CASP3, FOS
16
Apoptosis and survival Caspase cascade
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9.0CASP3, APP, IGF1, CASP9
17
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8.9APP, CREB1, CASP9, NOS1, CASP3
18
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8.8CASP3, CAMK4, CREB1, PLAT, CASP9
19
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8.8CASP3, CASP9, IGF1, FOS
208.8FOS, CASP3, ITGB1
21
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8.8ITGAV, FOS, CASP9, CREB1
228.7APP, CASP9, CASP3, CREB1, IGF1
23
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8.7APP, FOS, CASP3, CREB1, CASP9
24
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8.6CREB1, FOS, CAMK4, BMP7, NOS1
25
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8.6ITGAV, ITGB1, BMP7
26
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8.6BMP7, ITGAV, CREB1, FOS
27
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8.5CREB1, IGF1, FOS, CAMK4, CASP3
28
Development Prolactin receptor signaling
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8.5ITGB1, CASP3, FOS, CREB1
29
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8.4CASP3, CASP9, ITGAV, ITGB1
30
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8.4CASP9, IGF1, BMP7, FOS, CASP3
31
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8.3CREB1, BMP7, CASP9, CASP3, FOS, CAMK4
32
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8.3CAMK4, FOS, CREB1, NOS1, CASP3, APP
33
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8.2ITGAV, BMP7, ITGB1, APP
34
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8.2CASP9, FOS, ITGB1, ITGAV
35
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8.2CREB1, ITGAV, ITGB1, FOS
368.2ITGAV, CASP3, IGF1, ITGB1
37
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8.0IGF1, CASP3, ITGB1, CASP9, FOS
38
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8.0ITGAV, IGF1, ITGB1, FOS
397.9ITGB1, CASP9, CREB1, ITGAV, IGF1
40
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7.9ITGB1, CREB1, FOS, CASP3, CAMK4, CASP9
41
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7.9CREB1, ITGAV, ITGB1, FOS, CASP3
42
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7.7CREB1, IGF1, ITGB1, ITGAV, CAMK4, CASP9
43
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7.5CAMK4, IGF1, ITGB1, ITGAV, CREB1, BMP7
447.4CASP9, IGF1, CASP3, FOS, ITGAV, ITGB1
45
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7.3CREB1, APP, CASP9, CAMK4, ITGAV, FOS
46
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6.9CAMK4, FOS, CASP9, BMP7, CASP3, ITGB1
47
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6.8ITGAV, CREB1, FOS, APP, CASP9, CASP3
48
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6.7CASP3, CASP9, FOS, BMP7, ITGAV, CREB1
49
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6.7BMP7, ITGAV, CASP3, CASP9, CREB1, ITGB1
50
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6.5PLAT, CREB1, CAMK4, IGF1, CASP9, APP

Compounds for genes affiliated with Cerebral Hypoxia

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Cerebral Hypoxia according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1butyrate4510.5APP
2gnrh4510.1PLAT, CREB1
3pdtc4510.0NOS1, FOS
4glutamate4510.0PLAT, APP
5sulindac sulfide459.9APP, CASP9, CASP3
6s-nitroso-n-acetylpenicillamine459.8CASP3, CASP9, NOS1
7h2o2459.8CASP9, FOS, CREB1
8ly294002459.8CASP9, FOS, CREB1
9ethidium bromide459.7CASP3, CASP9, PLAT
103-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.7CASP3, CASP9, APP
11cd 437459.7FOS, CASP9, CASP3
12manidipine459.5PLAT, FOS
1315-deoxy-delta-12,14-prostaglandin j2459.4CASP3, CASP9, FOS, CREB1
14chelerythrine459.4FOS, CREB1, IGF1
15thapsigargin45 6010.4CREB1, APP, CASP9, CASP3
16n-(4-hydroxyphenyl)retinamide459.4CASP3, CASP9, IGF1
17valproate459.4APP, CREB1, IGF1
18simvastatin45 50 60 29 11 2414.4CASP3, CASP9, APP, PLAT
195-hydroxytryptamine459.4NOS1, PLAT, CREB1, APP
206-hydroxydopamine459.3CREB1, FOS, APP, CASP3
21corticosterone45 60 2411.3NOS1, CREB1, FOS, APP
22carbachol45 29 1111.3APP, FOS, CREB1, NOS1
23lactacystin459.3NOS1, CREB1, APP, CASP9, CASP3
24isoproterenol45 1110.3NOS1, PLAT, CREB1, APP
25nmda45 2910.1CAMK4, CASP9, APP, FOS, NOS1
264-hydroxynonenal45 2410.1CASP3, CASP9, APP, FOS, CREB1
27curcumin459.1CASP3, CASP9, APP, FOS, CREB1
28etoposide45 50 60 1112.0IGF1, CREB1, CASP9, CASP3
29creatinine459.0NOS1, IGF1, BMP7, APP
30rapamycin459.0IGF1, CREB1, BMP7, CASP9, CASP3
31titanium459.0ITGB1, ITGAV, BMP7
32sp 60012545 609.9CASP3, CASP9, FOS, ITGB1
33retinoid458.8CAMK4, CASP9, FOS, CREB1
34dopamine45 29 11 2411.7APP, FOS, CREB1, IGF1, NOS1
35adenylate458.6APP, FOS, CREB1, PLAT, NOS1
36serine458.5CAMK4, APP, FOS, BMP7, ITGB1
37glutamine458.4APP, CREB1, ITGB1, IGF1, NOS1
38calcitriol45 60 11 2411.3FOS, BMP7, CREB1, ITGB1, IGF1
39cyclosporin a45 29 6010.3CASP3, CASP9, APP, ITGB1, PLAT, NOS1
40dexamethasone45 50 29 1111.2APP, FOS, BMP7, CREB1, ITGB1, NOS1
41actinomycin d458.1CASP3, CASP9, APP, FOS, CREB1, IGF1
42pd 98,059458.1CASP3, CASP9, FOS, CREB1, ITGB1, IGF1
43wortmannin458.1CASP3, CASP9, FOS, CREB1, ITGB1, IGF1
44phosphatidylinositol458.1CASP3, CASP9, FOS, CREB1, ITGB1, IGF1
45cysteine458.0CASP3, CASP9, APP, CREB1, ITGB1, PLAT
46sb 20358045 608.8CASP3, CASP9, FOS, CREB1, ITGB1, IGF1
47genistein45 29 60 2 11 2412.8CASP3, CASP9, FOS, CREB1, ITGB1, IGF1
48tyrosine456.9CAMK4, FOS, BMP7, CREB1, ITGAV, ITGB1
49vegf456.7CASP3, APP, FOS, BMP7, CREB1, ITGAV
50retinoic acid45 247.6NOS1, CASP3, CASP9, APP, FOS, BMP7

GO Terms for genes affiliated with Cerebral Hypoxia

Sources:
16Gene Ontology
See all sources

Cellular components related to Cerebral Hypoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synapseGO:0452029.3NOS1, PLAT, APP
2cell surfaceGO:0099867.9PLAT, ITGB1, ITGAV, APP

Biological processes related to Cerebral Hypoxia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:00863510.0CASP9, CASP3
2Type I pneumocyte differentiationGO:0605099.9IGF1, CREB1
3SMAD protein signal transductionGO:0603959.4FOS, BMP7
4neurotrophin TRK receptor signaling pathwayGO:0480119.4CASP3, CAMK4, CASP9, CREB1
5phosphatidylinositol-mediated signalingGO:0480159.4IGF1, CREB1, CASP9
6negative regulation of extrinsic apoptotic signaling pathwayGO:20012379.3IGF1, ITGAV
7fibroblast growth factor receptor signaling pathwayGO:0085439.3CREB1, CASP9, CAMK4
8negative regulation of neuron differentiationGO:0456659.1ITGB1, BMP7, APP
9innate immune responseGO:0450878.9CAMK4, CASP9, APP, FOS, CREB1
10positive regulation of apoptotic processGO:0430658.8CASP3, CASP9, BMP7, ITGB1
11positive regulation of transcription, DNA-dependentGO:0458938.7CAMK4, FOS, BMP7, CREB1, IGF1
12extracellular matrix organizationGO:0301988.4ITGB1, ITGAV, BMP7, APP
13axon guidanceGO:0074118.4BMP7, CREB1, ITGAV, ITGB1
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.3APP, FOS, BMP7, CREB1, IGF1, NOS1
15blood coagulationGO:0075967.7NOS1, PLAT, IGF1, ITGB1, ITGAV, APP

Molecular functions related to Cerebral Hypoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.5NOS1, CASP9, APP, FOS, BMP7, CREB1

Products for genes affiliated with Cerebral Hypoxia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Hypoxia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet