MCID: CRB090
MIFTS: 35

Cerebral Hypoxia malady

Summaries for Cerebral Hypoxia

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

MalaCards: Cerebral Hypoxia is related to ischemia and dementia. An important gene associated with Cerebral Hypoxia is CASP9 (caspase 9, apoptosis-related cysteine peptidase), and among its related pathways are CaMK IV-mediated phosphorylation of CREB and Apoptotic factor-mediated response. The compounds butyrate and gnrh have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are vision/eye and renal/urinary system.

Wikipedia:63 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen) specifically involving the brain; when... more...

Aliases & Classifications for Cerebral Hypoxia

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43NINDS, 44Novoseek
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Aliases & Descriptions:

cerebral hypoxia 43 44


Related Diseases for Cerebral Hypoxia

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.4CREB1, PLAT, NOS1, BMP7, CASP3, CASP9
2dementia29.9APP, NOS1
3hypertension29.9IGF1, PLAT
4brain ischemia29.9NOS1, APP, PLAT
5vascular disease29.9CASP9, CASP3, NOS1, CREB1, FOS
6cerebritis11.1
7neuronitis10.6
8transient cerebral ischemia10.3
9anoxia10.2
10hypoxia10.2
11cerebral artery occlusion10.1
12multiple sclerosis10.0CASP9
13chondrosarcoma10.0BMP7
14tetanus10.0APP
15choriocarcinoma10.0CREB1
16galactosemia10.0IGF1
17multiple myeloma10.0IGF1
18encephalitis10.0APP
19anorexia nervosa10.0IGF1
20uremia10.0IGF1
21oral cancer10.0CASP3, CASP9
22pneumonia10.0NOS1, CASP9
23medulloblastoma10.0CASP9, CASP3
24malignant glioma10.0CASP3, CASP9
25cervical cancer10.0CASP9, CASP3
26nephrotic syndrome10.0ITGB1
27neuroepithelioma10.0CASP3, NOS1
28infertility10.0CASP9, ITGB1
29sarcoma10.0ITGB1, CASP9
30acute leukemia10.0CREB1
31endometriosis10.0ITGB1, CASP9
32deficiency anemia10.0NOS1
33influenza10.0NOS1, CREB1
34hyperhomocysteinemia10.0PLAT
35pituitary adenoma10.0CREB1, IGF1
36bipolar disorder10.0CREB1, NOS1
37lung cancer10.0APP, IGF1
38hepatitis b10.0FOS
39coronary heart disease10.0PLAT
40synovitis10.0ITGB1
41acute myocardial infarction10.0PLAT, NOS1
42myocardial infarction10.0NOS1, PLAT
43stroke, ischemic10.0BMP7, PLAT
44stroke, hemorrhagic10.0APP, PLAT
45hypogonadism10.0IGF1
46stomach cancer10.0CASP3, CASP9, ITGB1
47morphine dependence10.0FOS
48cataract10.0CASP9, FOS
49obesity10.0NOS1, IGF1, CREB1
50prion disease10.0APP, CREB1, NOS1

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to cerebral hypoxia

Clinical Features for Cerebral Hypoxia

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Drugs & Therapeutics for Cerebral Hypoxia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebral Hypoxia

Drug clinical trials:

Search ClinicalTrials for Cerebral Hypoxia

Search NIH Clinical Center for Cerebral Hypoxia

Search CenterWatch for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

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Anatomical Context for Cerebral Hypoxia

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32MalaCards
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MalaCards organs/tissues related to Cerebral Hypoxia:

32
Brain

Animal Models for Cerebral Hypoxia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cerebral Hypoxia:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.3NOS1, PLAT, BMP7
2MP:00053679.0BMP7, ITGAV, NOS1
3MP:00053809.0CASP9, BMP7, ITGB1
4MP:00053778.8ITGB1, FOS, BMP7
5MP:00053898.7CREB1, ITGB1, CAMK4, CASP3, APP
6MP:00053798.1FOS, BMP7, CREB1, ITGB1, CAMK4, CASP3
7MP:00036317.9CREB1, BMP7, PLAT, CASP9, CAMK4, CASP3
8MP:00107717.8FOS, APP, CAMK4, CASP3, ITGB1, BMP7
9MP:00053887.8CREB1, IGF1, NOS1, BMP7, ITGB1, CASP3
10MP:00053697.4ITGB1, APP, IGF1, CASP3, CREB1, ITGAV
11MP:00053767.3ITGB1, ITGAV, CREB1, APP, CAMK4, IGF1
12MP:00053907.3CAMK4, CASP3, NOS1, PLAT, IGF1, ITGB1
13MP:00053827.2ITGAV, CASP9, CASP3, FOS, BMP7, ITGB1
14MP:00053817.2CASP3, ITGAV, BMP7, NOS1, ITGB1, PLAT
15MP:00028737.1ITGB1, IGF1, NOS1, BMP7, FOS, CREB1
16MP:00053856.7IGF1, PLAT, NOS1, ITGB1, ITGAV, CREB1
17MP:00053866.6PLAT, ITGB1, ITGAV, CREB1, FOS, NOS1
18MP:00053976.6ITGB1, CASP3, NOS1, CAMK4, PLAT, IGF1
19MP:00053846.0CREB1, ITGAV, FOS, CASP9, CAMK4, CASP3
20MP:00053875.6BMP7, CASP9, APP, FOS, IGF1, CREB1
21MP:00053785.6CASP3, NOS1, PLAT, IGF1, ITGB1, ITGAV
22MP:00107685.5FOS, ITGB1, PLAT, ITGAV, CREB1, NOS1

Publications for Cerebral Hypoxia

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Genetic Variations for Cerebral Hypoxia

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Expression for genes affiliated with Cerebral Hypoxia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for genes affiliated with Cerebral Hypoxia

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Sources:
53Reactome, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 4Cell Signaling Technology, 55SinoBiological, 12EMD Millipore, 52R&D Systems, 59Tocris Bioscience
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Pathways related to Cerebral Hypoxia according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9CREB1, CAMK4
2
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9.9CASP9, CASP3
3
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9.7ITGB1
4
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9.5NOS1, CASP9, CASP3
59.5CASP3, CASP9, APP
6
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9.4CAMK4, IGF1, CREB1
7
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9.3CASP3, CASP9, FOS
89.2CAMK4, APP, CREB1, NOS1
99.1PLAT, IGF1, BMP7
109.1FOS, CASP9, CAMK4, CASP3
11
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9.0NOS1, CREB1, FOS, CAMK4
12
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9.0IGF1, CREB1, CASP9, CASP3
13
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9.0CREB1, FOS, CASP9, CASP3
14
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9.0CASP9, CASP3, FOS, CREB1
159.0CAMK4, CREB1, CASP3, FOS
16
Apoptosis and survival Caspase cascade
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9.0CASP3, APP, IGF1, CASP9
17
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8.9APP, CREB1, CASP9, NOS1, CASP3
18
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8.8CASP3, CAMK4, CREB1, PLAT, CASP9
19
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8.8CASP3, CASP9, IGF1, FOS
208.8FOS, CASP3, ITGB1
21
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8.8ITGAV, FOS, CASP9, CREB1
228.7APP, CASP9, CASP3, CREB1, IGF1
23
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8.7APP, FOS, CASP3, CREB1, CASP9
24
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8.6CREB1, FOS, CAMK4, BMP7, NOS1
25
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8.6ITGAV, ITGB1, BMP7
26
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8.6BMP7, ITGAV, CREB1, FOS
27
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8.5CREB1, IGF1, FOS, CAMK4, CASP3
28
Development Prolactin receptor signaling
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8.5ITGB1, CASP3, FOS, CREB1
29
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8.4CASP3, CASP9, ITGAV, ITGB1
30
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8.4CASP9, IGF1, BMP7, FOS, CASP3
31
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8.3CREB1, BMP7, CASP9, CASP3, FOS, CAMK4
32
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8.3CAMK4, FOS, CREB1, NOS1, CASP3, APP
33
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8.2ITGAV, BMP7, ITGB1, APP
34
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8.2CASP9, FOS, ITGB1, ITGAV
35
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8.2CREB1, ITGAV, ITGB1, FOS
368.2ITGAV, CASP3, IGF1, ITGB1
37
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8.0IGF1, CASP3, ITGB1, CASP9, FOS
38
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8.0ITGAV, IGF1, ITGB1, FOS
397.9ITGB1, CASP9, CREB1, ITGAV, IGF1
40
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7.9ITGB1, CREB1, FOS, CASP3, CAMK4, CASP9
41
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7.9CREB1, ITGAV, ITGB1, FOS, CASP3
42
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7.7CREB1, IGF1, ITGB1, ITGAV, CAMK4, CASP9
43
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7.5CAMK4, IGF1, ITGB1, ITGAV, CREB1, BMP7
447.4CASP9, IGF1, CASP3, FOS, ITGAV, ITGB1
45
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7.3CREB1, APP, CASP9, CAMK4, ITGAV, FOS
46
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6.9CAMK4, FOS, CASP9, BMP7, CASP3, ITGB1
47
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6.8ITGAV, CREB1, FOS, APP, CASP9, CASP3
48
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6.7CASP3, CASP9, FOS, BMP7, ITGAV, CREB1
49
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6.7BMP7, ITGAV, CASP3, CASP9, CREB1, ITGB1
50
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6.5PLAT, CREB1, CAMK4, IGF1, CASP9, APP

Compounds for genes affiliated with Cerebral Hypoxia

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Cerebral Hypoxia according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1butyrate4410.5APP
2gnrh4410.1CREB1, PLAT
3pdtc4410.0FOS, NOS1
4glutamate4410.0PLAT, APP
5sulindac sulfide449.9CASP9, CASP3, APP
6s-nitroso-n-acetylpenicillamine449.8CASP9, CASP3, NOS1
7h2o2449.8FOS, CREB1, CASP9
8ly294002449.8FOS, CASP9, CREB1
9ethidium bromide449.7CASP3, CASP9, PLAT
103-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.7CASP3, CASP9, APP
11cd 437449.7CASP9, FOS, CASP3
12manidipine449.5FOS, PLAT
13n-(4-hydroxyphenyl)retinamide449.5CASP9, CASP3, IGF1
1415-deoxy-delta-12,14-prostaglandin j2449.4FOS, CASP9, CREB1, CASP3
15chelerythrine449.4IGF1, CREB1, FOS
16thapsigargin44 5910.4CASP9, APP, CREB1, CASP3
17simvastatin44 49 59 28 11 2414.4PLAT, CASP3, CASP9, APP
185-hydroxytryptamine449.4APP, CREB1, PLAT, NOS1
196-hydroxydopamine449.3CREB1, APP, FOS, CASP3
20valproate449.3CREB1, APP, IGF1
21corticosterone44 59 2411.3APP, NOS1, FOS, CREB1
22carbachol44 28 1111.3NOS1, CREB1, APP, FOS
23lactacystin449.3APP, CASP9, NOS1, CREB1, CASP3
24isoproterenol44 1110.3NOS1, PLAT, CREB1, APP
25nmda44 2810.1APP, NOS1, FOS, CAMK4, CASP9
264-hydroxynonenal44 2410.1FOS, CREB1, CASP3, CASP9, APP
27curcumin449.1FOS, CREB1, CASP9, CASP3, APP
28etoposide44 49 59 1112.0CASP9, CREB1, IGF1, CASP3
29creatinine449.0APP, BMP7, IGF1, NOS1
30rapamycin449.0BMP7, CASP9, CASP3, CREB1, IGF1
31titanium449.0BMP7, ITGAV, ITGB1
32sp 60012544 599.9FOS, CASP3, CASP9, ITGB1
33retinoid448.8CASP9, CREB1, FOS, CAMK4
34dopamine44 28 11 2411.7IGF1, CREB1, NOS1, FOS, APP
35adenylate448.6NOS1, PLAT, CREB1, FOS, APP
36serine448.5FOS, APP, CAMK4, BMP7, ITGB1
37glutamine448.4CREB1, APP, ITGB1, IGF1, NOS1
38calcitriol44 59 11 2411.3IGF1, BMP7, CREB1, ITGB1, FOS
39cyclosporin a44 28 5910.3CASP3, CASP9, ITGB1, PLAT, NOS1, APP
40dexamethasone44 49 28 1111.2APP, FOS, BMP7, CREB1, ITGB1, NOS1
41actinomycin d448.1CASP3, FOS, CREB1, IGF1, PLAT, CASP9
42pd 98,059448.1ITGB1, CREB1, FOS, CASP9, CASP3, IGF1
43wortmannin448.1CASP3, CASP9, FOS, IGF1, CREB1, ITGB1
44phosphatidylinositol448.1CREB1, ITGB1, IGF1, FOS, CASP9, CASP3
45cysteine448.0NOS1, CASP9, ITGB1, APP, PLAT, CREB1
46sb 20358044 598.8NOS1, CASP3, CASP9, FOS, CREB1, ITGB1
47genistein44 28 59 2 11 2412.8IGF1, FOS, ITGB1, CREB1, CASP9, CASP3
48tyrosine446.9CAMK4, BMP7, CREB1, ITGAV, ITGB1, IGF1
49vegf446.7BMP7, NOS1, IGF1, ITGB1, CASP3, FOS
50retinoic acid44 247.6NOS1, CASP3, CASP9, APP, FOS, BMP7

GO Terms for genes affiliated with Cerebral Hypoxia

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16Gene Ontology
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Cellular components related to Cerebral Hypoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synapseGO:0452029.3NOS1, PLAT, APP
2cell surfaceGO:0099867.9PLAT, ITGB1, ITGAV, APP

Biological processes related to Cerebral Hypoxia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:00863510.0CASP9, CASP3
2Type I pneumocyte differentiationGO:0605099.9CREB1, IGF1
3SMAD protein signal transductionGO:0603959.4BMP7, FOS
4neurotrophin TRK receptor signaling pathwayGO:0480119.4CREB1, CASP9, CAMK4, CASP3
5phosphatidylinositol-mediated signalingGO:0480159.4CASP9, CREB1, IGF1
6negative regulation of extrinsic apoptotic signaling pathwayGO:20012379.3IGF1, ITGAV
7fibroblast growth factor receptor signaling pathwayGO:0085439.3CREB1, CASP9, CAMK4
8negative regulation of neuron differentiationGO:0456659.1APP, BMP7, ITGB1
9innate immune responseGO:0450878.9CAMK4, APP, CASP9, FOS, CREB1
10positive regulation of apoptotic processGO:0430658.8ITGB1, BMP7, CASP9, CASP3
11positive regulation of transcription, DNA-dependentGO:0458938.7BMP7, IGF1, CREB1, FOS, CAMK4
12extracellular matrix organizationGO:0301988.4BMP7, APP, ITGAV, ITGB1
13axon guidanceGO:0074118.4ITGB1, ITGAV, CREB1, BMP7
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.3APP, NOS1, IGF1, BMP7, CREB1, FOS
15blood coagulationGO:0075967.7IGF1, APP, ITGAV, ITGB1, PLAT, NOS1

Molecular functions related to Cerebral Hypoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.5NOS1, CASP9, APP, FOS, BMP7, CREB1

Products for genes affiliated with Cerebral Hypoxia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Hypoxia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet