MCID: CRB090
MIFTS: 48

Cerebral Hypoxia malady

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Summaries for Cerebral Hypoxia

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44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

MalaCards: Cerebral Hypoxia is related to ischemia and memory impairment. An important gene associated with Cerebral Hypoxia is CASP9 (caspase 9, apoptosis-related cysteine peptidase), and among its related pathways are Amyotrophic lateral sclerosis (ALS) and p75(NTR)-mediated signaling. The compounds sulindac sulfide and cd 437 have been mentioned in the context of this disorder. Affiliated tissues include brain, spleen and cortex, and related mouse phenotypes are other and limbs/digits/tail.

Wikipedia:65 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen) specifically involving the brain; when... more...

Aliases & Classifications for Cerebral Hypoxia

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44NINDS, 45Novoseek
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Aliases & Descriptions:

cerebral hypoxia 44 45


Related Diseases for Cerebral Hypoxia

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.4BMP7, PLAT, CASP3, CASP9, CREB1, NOS1
2memory impairment30.0APP, CREB1
3brain ischemia30.0NOS1, PLAT, APP
4vascular disease30.0FOS, CASP3, CASP9, CREB1, NOS1
5hypoxia11.2
6cerebritis11.2
7neuronitis10.6
8brain injury10.4
9anoxia10.4
10traumatic brain injury10.3
11cerebral artery occlusion10.1
12bipolar disorder10.1CREB1, NOS1
13neuroepithelioma10.1NOS1, CASP3
14coffin-lowry syndrome10.1CREB1, FOS
15age related macular degeneration10.1PLAT
16myocardial infarction10.1NOS1, PLAT
17stroke, hemorrhagic10.0PLAT, APP
18prion disease10.0APP, CREB1, NOS1
19hemorrhage, intracerebral10.0APP, PLAT
20eye disease10.0FOS, CASP3
21thyroid cancer, anaplastic10.0BMP7, CASP3
22endometrial carcinoma10.0CREB1, CASP9, FOS
23parkinson's disease10.0NOS1, CASP9, CASP3, APP
24huntington's disease10.0APP, CASP3, CREB1, NOS1
25hyperglycemia10.0IGF1, CASP3, CREB1
26primary hyperoxaluria10.0FOS, BMP7, CASP3
27mental retardation10.0CREB1, FOS, APP
28factor v leiden thrombophilia10.0PLAT, CREB1, NOS1
29viral infectious disease10.0NOS1, CREB1, CASP9, ITGAV
30t-cell leukemia10.0FOS, CASP3, CASP9, CREB1
31myeloid leukemia10.0CREB1, CASP9, CASP3, FOS
32retinoblastoma10.0FOS, CASP3, CASP9, CREB1
33pulmonary edema10.0
34sudden infant death syndrome10.0
35moyamoya disease10.0
36dementia10.0
37dystonia10.0
38focal dystonia10.0
39hypertension10.0
40intracranial hypertension10.0
41lactic acidosis10.0
42laryngitis10.0
43migraine10.0
44wallerian degeneration10.0
45myoclonus10.0
46syncope10.0
47endotheliitis10.0
48toxic encephalopathy10.0APP, FOS, CASP3, CREB1
49amyotrophic lateral sclerosis10.0IGF1, APP, CASP3, NOS1
50b-cell lymphomas10.0ITGB1, CASP3, CASP9

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to cerebral hypoxia

Symptoms for Cerebral Hypoxia

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Drugs & Therapeutics for Cerebral Hypoxia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cerebral Hypoxia

Search NIH Clinical Center for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

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Anatomical Context for Cerebral Hypoxia

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33MalaCards
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MalaCards organs/tissues related to Cerebral Hypoxia:

33
Brain, Spleen, Cortex, Lung, Endothelial

Animal Models for Cerebral Hypoxia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cerebral Hypoxia:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.3NOS1, ITGB1, APP
2MP:00053718.2IGF1, FOS, ITGB1, BMP7
3MP:00053917.9FOS, ITGB1, BMP7, PLAT, CASP3, NOS1
4MP:00053777.8IGF1, FOS, ITGB1, BMP7, PLAT, CASP3
5MP:00107717.6IGF1, APP, FOS, ITGB1, BMP7, CASP3
6MP:00053817.6ITGB1, ITGAV, BMP7, PLAT, CASP3, NOS1
7MP:00053807.6FOS, ITGB1, ITGAV, BMP7, CASP9, CREB1
8MP:00053677.5IGF1, ITGB1, ITGAV, BMP7, CASP3, NOS1
9MP:00053887.5IGF1, ITGB1, BMP7, PLAT, CASP3, CASP9
10MP:00028737.4IGF1, APP, FOS, ITGB1, BMP7, CAMK4
11MP:00053827.3FOS, ITGB1, ITGAV, BMP7, PLAT, CASP3
12MP:00053907.0IGF1, FOS, ITGB1, BMP7, PLAT, CASP3
13MP:00053696.9IGF1, APP, ITGB1, ITGAV, PLAT, CASP3
14MP:00053866.8APP, FOS, ITGB1, ITGAV, PLAT, CASP3
15MP:00053796.7IGF1, FOS, ITGB1, ITGAV, BMP7, CASP3
16MP:00053896.7ITGB1, FOS, APP, IGF1, BMP7, PLAT
17MP:00053856.6IGF1, ITGB1, ITGAV, BMP7, PLAT, CASP3
18MP:00053976.6IGF1, FOS, ITGB1, ITGAV, PLAT, CASP3
19MP:00053766.2IGF1, APP, FOS, ITGB1, ITGAV, PLAT
20MP:00053846.0ITGB1, FOS, APP, IGF1, ITGAV, PLAT
21MP:00053875.9IGF1, APP, FOS, ITGB1, ITGAV, BMP7
22MP:00036315.6NOS1, IGF1, APP, FOS, ITGB1, ITGAV
23MP:00053785.6ITGAV, ITGB1, FOS, APP, IGF1, BMP7
24MP:00107685.6ITGAV, ITGB1, FOS, APP, IGF1, BMP7

Publications for Cerebral Hypoxia

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52PubMed
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Articles related to Cerebral Hypoxia:

(show top 50)    (show all 221)
idTitleAuthorsYear
1
Targeted drug delivery to treat pain and cerebral hypoxia. (23343976)
2013
2
Cognitive decline in moyamoya: influence of chronic cerebral hypoxia, history of stroke, or comorbid conditions? (22171927)
2012
3
Experimental evidence of the potential use of erythropoietin by intranasal administration as a neuroprotective agent in cerebral hypoxia. (21756166)
2011
4
Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia-ischemia. (19782128)
2010
5
Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia. (19168722)
2009
6
Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia. (19628795)
2009
7
Mild cerebral hypoxia-ischemia produces a sub-acute transient inflammatory response that is less selective and prolonged after a substantial insult. (19631731)
2009
8
Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms. (19815706)
2009
9
Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation. (19436314)
2009
10
"Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets. (17475224)
2007
11
Plasminogen activators contribute to impairment of hypercapnic and hypotensive cerebrovasodilation after cerebral hypoxia/ischemia in the newborn pig. (16141421)
2005
12
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. (15592434)
2005
13
Extracellular superoxide concentration increases following cerebral hypoxia but does not affect cerebral blood flow. (15245758)
2004
14
Delayed postischemic hypothermia improves long-term behavioral outcome after cerebral hypoxia-ischemia in neonatal rats. (11861942)
2002
15
Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia. (11275647)
2001
16
Detection and treatment of cerebral hypoxia key to avoiding intraoperative brain injuries. (12578096)
2000
17
Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats. (11154758)
2000
18
Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury. (11154759)
2000
19
Prevention of both T2- and diffusion-weighted increases in image intensity during cerebral hypoxia-ischemia in infant rats pretreated with dexamethasone. (10204774)
1999
20
Magnetic resonance imaging during cerebral hypoxia-ischemia: T2 increases in 2-week-old but not 4-week-old rats. (10022586)
1999
21
Cerebral hypoxia after cardiopulmonary resuscitation. (10073537)
1999
22
Metabolite changes in neonatal rat brain during and after cerebral hypoxia-ischemia: a magnetic resonance spectroscopic imaging study. (10195327)
1999
23
Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet. (9578400)
1998
24
Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia. (9836776)
1998
25
Lipid free radical generation and brain cell membrane alteration following nitric oxide synthase inhibition during cerebral hypoxia in the newborn piglet. (9326283)
1997
26
Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats. (9089690)
1997
27
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists. (9364488)
1997
28
Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study. (9205806)
1997
29
Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. (8554576)
1995
30
DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat. (7614012)
1995
31
Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia. (8053660)
1994
32
Delayed-onset focal dystonia after diffuse cerebral hypoxia--two case reports. (8179837)
1993
33
Brain metabolism and blood flow in acute cerebral hypoxia studied by NMR spectroscopy and hydrogen clearance. (1550710)
1992
34
Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage. (1971436)
1990
35
Protective effect of KB-2796, a new calcium antagonist, in cerebral hypoxia and ischemia. (2241412)
1990
36
Cerebral hypoxia-ischemia in immature rats: methodological considerations. (3342854)
1988
37
Visual defects in children after cerebral hypoxia. (6525237)
1984
38
Early computed tomographic abnormalities following profound cerebral hypoxia. (6477220)
1984
39
The role of dilantin in the prevention of pulmonary edema associated with cerebral hypoxia. (7083868)
1982
40
Gray matter enhancement: a computerized tomographic sign of cerebral hypoxia. (7191063)
1980
41
Hyperventilation-induced cerebral hypoxia. (6774644)
1980
42
The morphologic consequences of cerebral hypoxia. (517287)
1979
43
Immediate restoration of central nervous system autonomic cardiopulmonary control: survival of "lethal" cerebral hypoxia by treatment with prostaglandin Bx. (401242)
1978
44
Effect of gamma-oxybutyric acid on the subcellular reaction to cerebral hypoxia [proceedings]. (885430)
1977
45
Barbiturate protection in cerebral hypoxia. (329713)
1977
46
Histopathologic and ultrastructural study in infantile encephalopathy by obstetrical cerebral hypoxia. (987614)
1976
47
The CSF lactate-pyruvate ratio in cerebral hypoxia. (5638919)
1968
48
Cardiac factors in cerebral hypoxia. (14020142)
1963
49
Action of cerebral hypoxia on the pulmonary arterial pressure of the dog (14437309)
1960
50
Cerebral hypoxia: aetiology and treatment. (13293396)
1956

Variations for Cerebral Hypoxia

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Expression for genes affiliated with Cerebral Hypoxia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for genes affiliated with Cerebral Hypoxia

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Sources:
50PathCards, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 5Cell Signaling Technology, 57SinoBiological, 60Thomson Reuters, 54R&D Systems, 61Tocris Bioscience
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Pathways related to Cerebral Hypoxia according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Amyotrophic lateral sclerosis (ALS)38
9.5NOS1, CASP9, CASP3
2
Show member pathways
9.5CASP9, CASP3, APP
39.2NOS1, CAMK4, APP, CREB1
4
Show member pathways
Alzheimers Disease38
9.2NOS1, CASP9, CASP3, APP
59.1FOS, CASP3, CASP9, CAMK4
6
Show member pathways
Calcium Regulation in the Cardiac Cell38
9.1CREB1, FOS, CAMK4, NOS1
79.1CASP3, FOS, CASP9, CREB1
8
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1CASP3, CASP9, CREB1, FOS
9
Show member pathways
9.1FOS, CASP3, CASP9, CREB1
109.1FOS, CREB1, CAMK4, CASP3
11
Show member pathways
DNA damage response38
8.9CREB1, IGF1, CASP3, CASP9
128.9IGF1, PLAT, BMP7
13
Show member pathways
8.9ITGB1, FOS, CASP9, CASP3
14
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
8.9CASP9, CASP3, APP, IGF1
15
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
8.9ITGB1, FOS, CREB1, CASP3
16
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.8IGF1, FOS, CASP9, CASP3
17
Show member pathways
8.8IGF1, FOS, CASP3, CAMK4
18
Show member pathways
8.8CAMK4, CASP9, PLAT, CREB1, CASP3
19
Show member pathways
8.7CASP3, CREB1, CASP9, FOS, APP
20
Show member pathways
8.7BMP7, ITGAV, ITGB1
21
Show member pathways
8.7FOS, BMP7, CAMK4, NOS1, CREB1
22
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.6ITGAV, FOS, CASP9, CREB1
23
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.6ITGB1, IGF1, FOS, CREB1
248.6IGF1, CREB1, CASP9, CASP3, APP
25
Show member pathways
8.5CASP9, ITGB1, ITGAV, CASP3
26
Show member pathways
8.4ITGAV, CASP9, FOS, ITGB1
27
Show member pathways
8.4NOS1, CREB1, CAMK4, CASP3, FOS, APP
28
Show member pathways
8.4ITGAV, BMP7, CASP3, ITGB1
29
Show member pathways
8.4FOS, CASP9, CASP3, IGF1, BMP7
30
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.4ITGB1, PLAT, FOS, IGF1
31
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.3FOS, CASP3, ITGB1, CREB1, CASP9, CAMK4
32
Show member pathways
Signal transduction PTEN pathway60
8.3FOS, CASP3, CASP9, ITGB1, IGF1
338.2IGF1, ITGB1, ITGAV, CASP3
34
Show member pathways
8.1CAMK4, FOS, BMP7, CASP3, NOS1, CASP9
35
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
8.1ITGAV, CAMK4, ITGB1, FOS, CREB1
36
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.1ITGB1, ITGAV, FOS, IGF1
37
Show member pathways
8.1IGF1, ITGAV, ITGB1, FOS
38
Show member pathways
8.0ITGAV, CREB1, CASP3, ITGB1, FOS
397.9IGF1, ITGB1, ITGAV, CREB1, CASP9
40
Show member pathways
7.8CAMK4, PLAT, CASP9, CASP3, CREB1, IGF1
41
Show member pathways
7.7ITGB1, ITGAV, CASP9, CAMK4, CREB1, IGF1
42
Show member pathways
7.5CREB1, CAMK4, BMP7, ITGAV, ITGB1, IGF1
437.4IGF1, FOS, ITGAV, CASP3, CASP9, ITGB1
44
Show member pathways
7.3BMP7, FOS, ITGB1, ITGAV, CREB1, IGF1
45
Show member pathways
7.3APP, ITGB1, ITGAV, NOS1, IGF1, PLAT
46
Show member pathways
7.1IGF1, CREB1, FOS, ITGB1, ITGAV, BMP7
47
Show member pathways
6.7CAMK4, CASP3, CREB1, NOS1, CASP9, BMP7
48
Show member pathways
6.7CREB1, CASP3, IGF1, CASP9, FOS, ITGB1
49
Show member pathways
6.7FOS, ITGB1, ITGAV, CASP3, CASP9, CREB1
50
Show member pathways
6.4CASP3, BMP7, CASP9, CREB1, ITGAV, IGF1

Compounds for genes affiliated with Cerebral Hypoxia

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Sources:
45Novoseek, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 11DrugBank, 51PharmGKB, 3BitterDB
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Compounds related to Cerebral Hypoxia according to GeneCards/GeneDecks:

(show top 50)    (show all 135)
idCompoundScoreTop Affiliating Genes
1sulindac sulfide459.8CASP9, APP, CASP3
2cd 437459.6FOS, CASP3, CASP9
315-deoxy-delta-12,14-prostaglandin j2459.5CASP9, FOS, CASP3, CREB1
4pdtc459.5FOS, CASP3, NOS1, CASP9
5ethidium bromide459.5CASP3, CASP9, PLAT
6s-nitroso-n-acetylpenicillamine459.4NOS1, CASP9, CASP3
76-hydroxydopamine459.4APP, CASP3, FOS, CREB1
8corticosterone45 61 2411.4NOS1, CREB1, FOS, APP
9egcg459.4CASP3, APP, CASP9, FOS
10carbachol45 29 1111.4CREB1, APP, FOS, NOS1
11thapsigargin45 6110.3CREB1, CASP9, CASP3, APP
12lactacystin459.3APP, NOS1, CASP9, CREB1, CASP3
135-hydroxytryptamine459.3CREB1, NOS1, APP, PLAT
14simvastatin45 51 61 29 24 1114.3CASP9, CASP3, APP, PLAT
15sp 60012545 6110.3CASP9, CASP3, ITGB1, FOS
163-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.2CASP3, CASP9, APP
17isoproterenol45 1110.2NOS1, CREB1, PLAT, APP
18retinoid459.2CREB1, CAMK4, CASP9, FOS
194-hydroxynonenal45 2410.2CASP9, APP, FOS, CREB1, CASP3
20chelerythrine459.2IGF1, FOS, CREB1
21curcumin459.1CASP9, APP, CREB1, CASP3, FOS
22butyrate459.1CREB1, CASP9, CASP3, FOS, APP
23pge2459.0BMP7, CASP9, CREB1, NOS1, FOS
24titanium459.0ITGAV, ITGB1, BMP7
25rapamycin458.9CREB1, CASP9, IGF1, CASP3, BMP7
26nmda45 299.9FOS, CASP9, CAMK4, CREB1, APP, NOS1
27ly294002458.8FOS, CREB1, CASP9, CASP3, IGF1
28h2o2458.8CASP9, CREB1, FOS, NOS1, CASP3, APP
29dopamine45 29 24 1111.7IGF1, NOS1, FOS, APP, CREB1
30glutamine458.7NOS1, CREB1, ITGB1, IGF1, APP
31gnrh458.6IGF1, CREB1, FOS, APP, PLAT
32glutamate458.6CREB1, NOS1, CASP9, FOS, APP, PLAT
33calcitriol45 61 24 1111.6BMP7, IGF1, FOS, ITGB1, CREB1
34cyclosporin a45 29 6110.5CASP9, PLAT, ITGB1, NOS1, APP, CASP3
35adenylate458.5NOS1, CREB1, PLAT, FOS, APP
36creatinine458.4APP, IGF1, NOS1, PLAT, BMP7
37pd 98,059458.4IGF1, FOS, CREB1, CASP9, CASP3, ITGB1
38wortmannin458.4ITGB1, CASP3, CASP9, IGF1, CREB1, FOS
39phosphatidylinositol458.3ITGB1, FOS, CREB1, IGF1, CASP9, CASP3
40cysteine458.2NOS1, CASP3, PLAT, APP, ITGB1, CREB1
41estrogen458.1IGF1, FOS, ITGB1, NOS1, BMP7, CREB1
42sb 20358045 619.1NOS1, CASP3, CASP9, ITGB1, FOS, IGF1
43genistein45 29 61 3 24 1113.1ITGB1, FOS, IGF1, CASP9, CASP3, CREB1
44actinomycin d458.0APP, CASP9, CASP3, PLAT, FOS, IGF1
45dexamethasone45 51 29 1110.6NOS1, BMP7, CASP9, CREB1, APP, IGF1
46tyrosine457.2BMP7, ITGAV, CAMK4, CREB1, ITGB1, FOS
47cycloheximide457.2CREB1, FOS, NOS1, IGF1, ITGB1, BMP7
48retinoic acid45 247.8NOS1, FOS, CASP9, CASP3, PLAT, BMP7
49vegf456.7CASP3, BMP7, ITGAV, FOS, ITGB1, APP
50serine456.5FOS, NOS1, CREB1, CAMK4, CASP9, IGF1

GO Terms for genes affiliated with Cerebral Hypoxia

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Sources:
16Gene Ontology
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Cellular components related to Cerebral Hypoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synapseGO:0452029.3APP, PLAT, NOS1
2integrin complexGO:0083059.0ITGAV, ITGB1
3cell surfaceGO:0099868.3PLAT, ITGAV, ITGB1, APP
4cytosolGO:0058298.1APP, FOS, CASP3, CASP9, CAMK4, NOS1
5extracellular vesicular exosomeGO:0700628.0CAMK4, PLAT, ITGAV, ITGB1, APP

Biological processes related to Cerebral Hypoxia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1glial cell apoptotic processGO:03434910.2CASP9, CASP3
2activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:00863510.1CASP3, CASP9
3platelet formationGO:03022010.1CASP9, CASP3
4positive regulation of osteoclast differentiationGO:0456729.9CREB1, FOS
5Type I pneumocyte differentiationGO:0605099.8CREB1, IGF1
6SMAD protein signal transductionGO:0603959.8BMP7, FOS
7fibroblast growth factor receptor signaling pathwayGO:0085439.8CASP9, CAMK4, CREB1
8neuron apoptotic processGO:0514029.8CASP3, APP
9epidermal growth factor receptor signaling pathwayGO:0071739.7CREB1, CAMK4, CASP9
10Fc-epsilon receptor signaling pathwayGO:0380959.6FOS, CASP9, CREB1
11dendrite developmentGO:0163589.6BMP7, APP
12neurotrophin TRK receptor signaling pathwayGO:0480119.6CASP3, CASP9, CAMK4, CREB1
13regulation of multicellular organism growthGO:0400149.5IGF1, APP
14phosphatidylinositol-mediated signalingGO:0480159.5CREB1, CASP9, IGF1
15negative regulation of neuron differentiationGO:0456659.5BMP7, ITGB1, APP
16branching morphogenesis of an epithelial tubeGO:0487549.4BMP7, IGF1
17positive regulation of apoptotic processGO:0430659.2ITGB1, BMP7, CASP3, CASP9
18innate immune responseGO:0450879.1APP, FOS, CASP9, CAMK4, CREB1
19extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.0CASP3, ITGAV, IGF1
20positive regulation of transcription, DNA-templatedGO:0458938.7IGF1, FOS, BMP7, CAMK4, CREB1
21negative regulation of extrinsic apoptotic signaling pathwayGO:20012378.7ITGAV, IGF1
22axon guidanceGO:0074118.7CREB1, BMP7, ITGAV, ITGB1
23extracellular matrix organizationGO:0301988.4APP, ITGB1, ITGAV, BMP7, CASP3
24positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IGF1, APP, FOS, BMP7, CREB1, NOS1
25blood coagulationGO:0075967.7NOS1, PLAT, ITGAV, ITGB1, APP, IGF1

Molecular functions related to Cerebral Hypoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:0016189.1ITGAV, ITGB1
2protein bindingGO:0055155.2NOS1, IGF1, APP, FOS, ITGB1, ITGAV

Products for genes affiliated with Cerebral Hypoxia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Hypoxia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet