Summaries for Cerebral Hypoxia

Sources:
31NINDS, 44Wikipedia, 22MalaCards
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NINDS: Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.31

MalaCards: Cerebral Hypoxia, also known as brain hypoxia, is related to hypoxia and cerebritis. An important gene associated with Cerebral Hypoxia is CREB1 (cAMP responsive element binding protein 1), and among its related pathways are Granzyme-B Pathway and GITR Pathway. The compounds gnrh and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen) specifically involving the brain; when...44 more...

Aliases & Descriptions for Cerebral Hypoxia

Sources:
31NINDS, 32Novoseek , 43UMLS
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cerebral hypoxia 31 32
brain hypoxia 43

Related Diseases for Cerebral Hypoxia

Sources:
13GeneCards, 14GeneDecks
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Diseases related to cerebral hypoxia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1hypoxia26.9CREB1, CAMK4, CASP9, PLAT, NOS1, BMP7
2cerebritis25.5PLAT, CREB1, CAMK4, CASP3, APP, NOS1
3brain ischemia25.3NOS1, PLAT, CASP9, FOS, APP, CASP3
4ischemia25.2PLAT, CREB1, CASP9, CASP3, FOS, BMP7
5thoracic cancer13.1CASP9, CASP3
6talipes equinovarus13.0CASP9, CASP3
7dentatorubral-pallidoluysian atrophy13.0CREB1, CASP3
8cadasil12.9CASP3, APP
9prion disease12.7APP, NOS1, CREB1
10coffin-lowry syndrome12.7FOS, CREB1
11amyotrophic lateral sclerosis (als)12.7CASP9, NOS1, CASP3
12chronic myeloid leukemia12.6CREB1, CASP9, CASP3
13lung adenocarcinoma12.6CREB1, CASP3, CASP9
14tetanus12.6CREB1, CASP3, APP
15hydrocephalus12.5CASP3, NOS1, APP
16factor v leiden thrombophilia12.5PLAT, NOS1, CREB1
17polyneuropathy12.5APP, NOS1, PLAT
18myeloproliferative disorder12.5PLAT, CASP3, CREB1
19major depressive disorder12.4CREB1, NOS1, BMP7
20stomach carcinoma12.4CASP3, CASP9, PLAT
21myocarditis12.4CASP3, CASP9, PLAT
22drug dependence12.4FOS, NOS1, CREB1
23status epilepticus12.3CASP3, CASP9, FOS
24parkinson's disease12.2APP, CASP9, NOS1, CASP3
25cerebral artery occlusion12.2NOS1, PLAT, FOS
26keloids12.2CASP3, FOS, CASP9
27rabies12.2NOS1, CASP9, APP
28hearing loss12.1PLAT, NOS1, CASP9, CASP3
29non-hodgkin lymphoma12.1CASP9, CREB1, NOS1, CASP3
30human t-cell leukemia virus type 112.1FOS, CASP3, CREB1
31dementia12.1APP, CREB1, NOS1, CASP3
32infertility12.1CASP3, CASP9, APP, NOS1
33cerebral infarction12.1NOS1, PLAT, BMP7, CREB1
34mental retardation syndrome12.0CREB1, FOS, APP
35influenza12.0PLAT, CASP9, NOS1, CREB1
36atrial fibrillation12.0PLAT, NOS1, CASP3
37chagas disease12.0PLAT, FOS, CREB1
38differentiating neuroblastoma11.9APP, CREB1, NOS1, FOS
39t-cell leukemia11.9CASP3, CASP9, FOS, CREB1
40malignant glioma11.9CASP3, CASP9, PLAT, BMP7
41squamous cell carcinoma of the head and neck11.9FOS, CASP9, CASP3
42neurodegenerative disease11.9CASP3, APP, NOS1, CREB1, CASP9
43huntington's disease11.9APP, CASP9, NOS1, CREB1, CASP3
44dmd-associated dilated cardiomyopathy11.9FOS, PLAT, CASP9, CREB1
45non-small cell lung carcinoma11.8NOS1, CASP9, CASP3, FOS
46anorexia nervosa11.8NOS1, FOS, PLAT, CREB1
47encephalitis11.8CASP3, CASP9, FOS, APP
48endometrial cancer11.8FOS, CREB1, CASP9, CASP3
49cystic fibrosis11.8CREB1, CASP3, PLAT, NOS1
50cataract11.7CASP3, FOS, PLAT, CASP9

Graphical network of the top 20 diseases related to cerebral hypoxia:



Graphical network of diseases related to cerebral hypoxia

Clinical Features for Cerebral Hypoxia

Drugs & Therapeutics for Cerebral Hypoxia

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for cerebral hypoxia

Drug clinical trials:

Search ClinicalTrials for cerebral hypoxia

Search NIH Clinical Center for cerebral hypoxia

Search CenterWatch for cerebral hypoxia

Genetic Tests for Cerebral Hypoxia

Anatomical Context for Cerebral Hypoxia

Sources:
22MalaCards
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MalaCards organs/tissues related to cerebral hypoxia:

22
Brain

Phenotypes for genes affiliated with Cerebral Hypoxia

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25MGI
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Publications for genes affiliated with Cerebral Hypoxia

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35PubMed
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Articles related to cerebral hypoxia:

idTitleAuthorsYearAffiliating Genes
1Red blood cells-coupled tPA prevents impairment of ce rebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/i schemia through inhibition of ERK MAPK activation. (19436314)Armstead W.M.... Muzykantov V.R.2009PLAT
2Molecular factors of cerebral hypoxia-ischemia (8681202)Macaya A.... Ferrer I.1996FOS
3Neuroprotective effect of human osteogenic protein-1 in a rat model of cerebral hypoxia/ischemia. (7617293)Perides G.... Charness M.E.1995BMP7

Expression for genes affiliated with Cerebral Hypoxia

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Cerebral Hypoxia

Pathways for genes affiliated with Cerebral Hypoxia

Sources:
36QIAGEN, 10EMD Millipore, 41Thomson Reuters, 20KEGG, 3Cell Signaling Technology
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Pathways related to cerebral hypoxia according to GeneDecks:

(show all 44)
idPathwayScoreTop Affiliating Genes
1Granzyme-B Pathway369.9CASP3, CASP9
2GITR Pathway369.8CASP9, CASP3
3Pathogenesis of ALS369.8CASP3, CASP9
4Apoptosis and survival NGF signaling pathway109.8CASP9, CASP3
5Apoptosis and survival_NGF signaling pathway419.8CASP9, CASP3
6DR3 Signaling369.8CASP3, CASP9
7Granzyme Pathway369.8CASP9, CASP3
8IGF1R Signaling369.7CAMK4, CASP9, CREB1
9TRKA Signaling369.6CASP9, CREB1, CASP3
10Amyotrophic lateral sclerosis (ALS)209.6CASP9, NOS1, CASP3
11TWEAK Pathway369.6CASP9, CASP3
12Tuberculosis209.6CASP3, CASP9, CREB1
13UVA-Induced MAPK Signaling369.5CASP3, FOS
14Huntingtons disease209.5CREB1, CASP3, CASP9
15PGC1Alpha Pathway369.5CREB1, BMP7, CAMK4
16Presenilin-Mediated Signaling369.4APP, CASP9, CASP3
17Endothelin-1 Signaling Pathway369.4CASP3, BMP7, NOS1
18Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2419.4NOS1, FOS
19Neuroscience39.4NOS1, CAMK4, CREB1, APP
20Neuropathic Pain-Signaling in Dorsal Horn Neurons369.4FOS, NOS1, CREB1
21Dopamine-DARPP32 Feedback onto cAMP Pathway369.3CAMK4, CREB1, NOS1
22Cholinergic synapse209.3CREB1, FOS, CAMK4
23Cellular Transformation by HTLV1369.3CREB1, FOS
24Osteoclast differentiation209.3CREB1, CAMK4, FOS
25Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2109.3NOS1, FOS
26CD27 Pathway369.3FOS, CASP3
27p53 Mediated Apoptosis369.3CASP9, CASP3, BMP7
28TRAIL Pathway369.2CASP9, CASP3
29Mitochondrial Apoptosis369.2CASP9, CASP3, BMP7
30Alzheimers disease209.2APP, CASP3, CASP9, NOS1
31TNFR1 Pathway369.1FOS, CASP3, CASP9
32TNF Signaling369.1CASP3, FOS, CASP9
33Colorectal cancer209.1CASP3, CASP9, FOS
34Ceramide Pathway369.1CASP3, FOS, CASP9
3514-3-3 Induced Apoptosis369.1CASP3, FOS, CASP9
36TNF Superfamily Pathway369.1CASP9, CASP3, FOS
37p53 Signaling369.1FOS, CASP9, CASP3
38Cellular Apoptosis Pathway369.1CASP9, CASP3, BMP7
39CRHR Pathway369.0NOS1, CREB1, FOS, CAMK4
40Glucocorticoid Receptor Signaling368.9FOS, CREB1, BMP7
41ERK5 Signaling368.9BMP7, FOS, CREB1
42DHA Signaling368.9BMP7, CASP3, APP, CASP9
43BMP Pathway368.8CREB1, CAMK4, FOS, BMP7
44ILK Signaling368.2FOS, CASP3, CASP9, CREB1, BMP7

Compounds for genes affiliated with Cerebral Hypoxia

Sources:
32Novoseek , 42Tocris Bioscience, 9DrugBank, 34PharmGKB, 18HMDB
See all sources

Compounds related to cerebral hypoxia according to GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1gnrh32 10.5CREB1
2rapamycin32 42 11.3CASP9
3threonine32 10.2CAMK4
4c2ceramide32 10.2CASP3
5isoproterenol32 9 9 12.1APP, CREB1
6n acetylcysteine32 9.9FOS
7h2o232 9.8CASP9, CREB1, NOS1
8atropine32 9 9 11.6CREB1, NOS1, APP
9d-api32 9.5CASP3, CASP9
10s-nitroso-n-acetylpenicillamine32 9.5CASP9, CASP3, NOS1
11sulindac sulfide32 9.5APP, CASP9, CASP3
12polyadenosine diphosphate ribose32 9.4CASP9, CASP3
13manidipine32 9.4PLAT, FOS
143-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32 9.4CASP3, CASP9, APP
15happ32 9.4FOS, APP
16ethidium bromide32 9.4PLAT, CASP3, CASP9
17tunicamycin32 9.3CASP9, APP, CASP3
18ly29400232 9.3FOS, CASP3
195-hydroxytryptamine32 9.2NOS1, CREB1, PLAT, APP
20thapsigargin32 42 10.1CASP9, APP, CREB1, CASP3
21cd 43732 9.1CASP9, CASP3, FOS
22ptio32 9.0NOS1, FOS
23anisomycin32 42 9 9 12.0CASP9, CREB1, FOS
24simvastatin32 34 42 9 18 9 13.9CASP9, APP, CASP3, PLAT
25corticosterone32 18 9.9APP, NOS1, CREB1, FOS
26sb 20358032 42 9.9CASP3, FOS, NOS1, CREB1
27lactacystin32 8.9APP, CASP3, CASP9, NOS1, CREB1
28retinoid32 8.9FOS, CAMK4, CASP9, CREB1
2915-deoxy-delta-12,14-prostaglandin j232 8.8CASP3, CREB1, CASP9, FOS
30pdtc32 8.8NOS1, CASP9, CASP3, FOS
316-hydroxydopamine32 8.8APP, FOS, CASP3, CREB1
32egcg32 8.7FOS, CASP9, CASP3, APP
33cyclosporin a32 42 9.6NOS1, CASP9, CASP3, APP, PLAT
34pd 98,05932 8.6CASP9, CASP3, FOS, CREB1
35genistein32 9 18 9 11.5FOS, CASP3, CREB1, NOS1, CASP9
36wortmannin32 42 9.4FOS, CASP9, CREB1, CASP3
374-hydroxynonenal32 18 9.4CASP9, CASP3, APP, FOS, CREB1
38curcumin32 8.4FOS, CASP3, CASP9, CREB1, APP
39butyrate32 8.4CREB1, CASP3, APP, FOS, CASP9
40adenylate32 8.3PLAT, FOS, CREB1, NOS1, APP
41pge232 8.3CREB1, NOS1, CASP9, FOS, BMP7
42glutamate32 8.3NOS1, PLAT, CASP9, APP, FOS
43cysteine32 8.2NOS1, CREB1, CASP9, CASP3, APP, PLAT
44nmda32 42 9.2CREB1, FOS, NOS1, CAMK4, APP, CASP9
45dexamethasone32 42 34 9 9 11.9FOS, BMP7, APP, CREB1, NOS1, CASP9
46actinomycin d32 7.9APP, FOS, CASP3, PLAT, CREB1, CASP9
47vegf32 7.8BMP7, FOS, APP, CASP3, CREB1, NOS1
48cycloheximide32 7.4PLAT, CREB1, CASP3, CASP9, BMP7, NOS1
49retinoic acid32 42 18 8.9CREB1, CASP9, CASP3, APP, FOS, BMP7
50serine32 6.5NOS1, BMP7, FOS, APP, CASP3, CAMK4

GO Terms for genes affiliated with Cerebral Hypoxia

Sources:
12Gene Ontology
See all sources

Cellular components related to cerebral hypoxia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synapseGO:0452029.2APP, PLAT, NOS1

Biological processes related to cerebral hypoxia according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:0086359.7CASP9, CASP3
2fibroblast growth factor receptor signaling pathwayGO:0085439.5CREB1, CASP9, CAMK4
3neuron apoptotic processGO:0514029.5APP, CASP3
4epidermal growth factor receptor signaling pathwayGO:0071739.5CREB1, CASP9, CAMK4
5regulation of apoptotic processGO:0429819.1CASP3, CASP9, CREB1
6dendrite developmentGO:0163589.1APP, BMP7
7SMAD protein signal transductionGO:0603959.1BMP7, FOS
8nerve growth factor receptor signaling pathwayGO:0480119.1CASP3, CAMK4, CASP9, CREB1
9positive regulation of transcription, DNA-dependentGO:0458938.3BMP7, FOS, CAMK4, CREB1

Molecular functions related to cerebral hypoxia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.5BMP7, FOS, APP, CASP3, CASP9, CREB1

Sources for Cerebral Hypoxia

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS