MCID: CRB090
MIFTS: 47

Cerebral Hypoxia

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Hypoxia

MalaCards integrated aliases for Cerebral Hypoxia:

Name: Cerebral Hypoxia 50 51
Brain Hypoxia 69

Classifications:



External Ids:

UMLS 69 C1527348

Summaries for Cerebral Hypoxia

NINDS : 50 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Cerebral Hypoxia, also known as brain hypoxia, is related to traumatic brain injury and hypoxia. An important gene associated with Cerebral Hypoxia is CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Epinephrine and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and endothelial, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Wikipedia : 72 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when... more...

Related Diseases for Cerebral Hypoxia

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 29.5 CASP3 IGF1
2 hypoxia 11.6
3 anoxia 11.5
4 brain ischemia 11.0
5 cerebritis 10.8
6 ischemia 10.6
7 neuronitis 10.2
8 brain injury 10.0
9 cardiac arrest 9.8
10 occlusion precerebral artery 9.8 CASP3 FOS
11 endotheliitis 9.7
12 aging 9.7
13 hydrops, lactic acidosis, and sideroblastic anemia 9.7
14 encephalopathy 9.7
15 cerebral artery occlusion 9.7
16 ocular dominance 9.7 CREB1 NOS1
17 osteogenic sarcoma 9.6 CASP3 FOS IGF1
18 pulmonary edema 9.6
19 syncope 9.6
20 dementia 9.6
21 migraine with or without aura 1 9.6
22 vascular disease 9.6
23 aganglionosis, total intestinal 9.6
24 epilepsy 9.6
25 moyamoya disease 1 9.6
26 sudden infant death syndrome 9.6
27 laryngitis 9.6
28 mungan syndrome 9.6
29 lactic acidosis 9.6
30 episodic pain syndrome, familial, 1 9.6
31 dystonia 9.6
32 intracranial hypertension 9.6
33 wallerian degeneration 9.6
34 focal dystonia 9.6
35 myoclonus 9.6
36 newcastle disease 9.4 CASP3 CASP9
37 neuroblastoma 9.0 CASP3 CASP9 CREB1 ITGB1

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to Cerebral Hypoxia

Symptoms & Phenotypes for Cerebral Hypoxia

GenomeRNAi Phenotypes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 PTK2
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Cerebral Hypoxia:

43 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 PTK2 BCAR1 CAMK4 CASP3 CASP9 CREB1
2 growth/size/body region MP:0005378 10.26 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
3 endocrine/exocrine gland MP:0005379 10.24 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
4 cardiovascular system MP:0005385 10.23 BCAR1 CASP3 CASP9 CREB1 IGF1 ITGAV
5 mortality/aging MP:0010768 10.17 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
6 hematopoietic system MP:0005397 10.16 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
7 homeostasis/metabolism MP:0005376 10.15 CAMK4 CASP3 CREB1 FOS IGF1 ITGAV
8 immune system MP:0005387 10.13 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
9 embryo MP:0005380 10.09 CREB1 FOS ITGAV ITGB1 PTK2 BCAR1
10 nervous system MP:0003631 10.02 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
11 muscle MP:0005369 10.01 NOS1 PTK2 BCAR1 CASP3 CREB1 IGF1
12 craniofacial MP:0005382 9.96 CASP3 CASP9 FOS ITGAV ITGB1
13 integument MP:0010771 9.93 CAMK4 CASP3 FOS IGF1 ITGB1 PTK2
14 normal MP:0002873 9.8 CAMK4 CREB1 FOS IGF1 ITGB1 NOS1
15 neoplasm MP:0002006 9.77 FOS IGF1 ITGAV ITGB1 PTK2
16 reproductive system MP:0005389 9.76 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1
17 respiratory system MP:0005388 9.5 CASP3 CASP9 CREB1 IGF1 ITGB1 NOS1
18 skeleton MP:0005390 9.17 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1

Drugs & Therapeutics for Cerebral Hypoxia

Drugs for Cerebral Hypoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
3
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
5 Racepinephrine Approved Phase 4 329-65-7
6 Ether Phase 4
7 Central Nervous System Depressants Phase 4,Phase 2
8 Anesthetics Phase 4,Phase 2
9 Anesthetics, General Phase 4,Phase 2
10 Anesthetics, Inhalation Phase 4,Phase 2
11 Anesthetics, Intravenous Phase 4
12 Hypnotics and Sedatives Phase 4
13 Epinephryl borate Phase 4
14 Platelet Aggregation Inhibitors Phase 4
15
Mannitol Approved, Investigational Phase 3 69-65-8 6251 453
16 diuretics Phase 3
17 Natriuretic Agents Phase 3
18 Xenon Phase 2
19
Temozolomide Approved, Investigational 85622-93-1 5394
20
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
21
Dopamine Approved 51-61-6, 62-31-7 681
22 tannic acid Approved, Nutraceutical
23
Glutamic Acid Approved, Nutraceutical 56-86-0 33032
24 Dopamine agonists
25 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol
26 Neurotransmitter Agents
27 Tranquilizing Agents
28 Dopamine Agents
29 Psychotropic Drugs
30 Antipsychotic Agents

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
2 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4 sodium bicarbonate
3 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
4 Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients Completed NCT00879892 Phase 2 xenon
5 Home Stimulation for Brain-Asphyxiated Infants Completed NCT00006516 Phase 2
6 CO2 (Carbon Dioxide) - Cerebral Oxygenation Recruiting NCT03338907 Phase 2 Oxycarbon (5% CO2+ 95% O2)
7 Lactate Therapy After Traumatic Brain Injury Recruiting NCT01573507 Phase 2
8 A Prospective Study With a New Device for the Monitoring of Cerebral Oxygenation on Cardiac Surgery Patients Terminated NCT00598936 Phase 1
9 Feasibility Trial to Maintain Normal Cerebral Oxygen Saturation in High-Risk Cardiac Surgery Completed NCT01432184
10 The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane Completed NCT01757561
11 The Impact of a Beach Chair Position During Shoulder Arthroscopy on Regional Cerebral Oxygen Saturation : Comparison of Interscalene Block and General Anesthesia Completed NCT02605005
12 Cerebral Responses During Exercise in Hypoxia Completed NCT01614119
13 Magnetic Resonance Biomarkers in Neonatal Encephalopathy Completed NCT01309711
14 Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study) Completed NCT01836302
15 Near INfrared Spectroscopy in Aortic valvE ReplacemenT Completed NCT01251328
16 CRRT for Glutamate Elimination After Cardiac Arrest Completed NCT02963298
17 Retrospective Evaluation of Melanocortin Receptor 4 Polymorphisms in Patients With GBM Treated With Radiochemotherapy Completed NCT02458508
18 Observational Study in Preterm Infants With Intracranial Hemorrhage Recruiting NCT01620203
19 Correlating Brain Tissue Oxygen and Regional Cerebral Oximetry Recruiting NCT03128957
20 Impact of Early Optimization of Brain Oxygenation on the Volume of Cerebral Lesions After Severe Traumatic Brain Injury Recruiting NCT02754063
21 The Effects of Hypobaria vs Hypoxia on Cerebral Functions. Active, not recruiting NCT03303118
22 Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia Active, not recruiting NCT02482571
23 Continuous Neurophysiological Monitoring Detection of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage Subjects Terminated NCT01343537 Early Phase 1

Search NIH Clinical Center for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

Anatomical Context for Cerebral Hypoxia

MalaCards organs/tissues related to Cerebral Hypoxia:

38
Brain, Cortex, Endothelial, Monocytes, Lung, Spleen

Publications for Cerebral Hypoxia

Articles related to Cerebral Hypoxia:

(show top 50) (show all 259)
# Title Authors Year
1
Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia-ischemia. ( 29355709 )
2018
2
Persistent generalized periodic discharges: A specific marker of fatal outcome in cerebral hypoxia. ( 27894023 )
2017
3
Effect of Intranasally Delivered rh-VEGF165 on Angiogenesis Following Cerebral Hypoxia-Ischemia in the Cerebral Cortex of Newborn Piglets. ( 29112164 )
2017
4
Cerebral Hypoxia Caused by Flow Confliction During Minimally Invasive Cardiac Surgery With Retrograde Perfusion: A Word of Caution. ( 29126685 )
2017
5
The role of SUMOylation in cerebral hypoxia and ischemia. ( 28323006 )
2017
6
Effect of Src Kinase inhibition on Cytochrome c, Smac/DIABLO and Apoptosis Inducing Factor (AIF) Following Cerebral Hypoxia-Ischemia in Newborn Piglets. ( 29192254 )
2017
7
Quantifying cerebral hypoxia by near-infrared spectroscopy tissue oximetry: the role of arterial-to-venous blood volume ratio. ( 28152128 )
2017
8
Administration of Huperzia quadrifariata Extract, a Cholinesterase Inhibitory Alkaloid Mixture, has Neuroprotective Effects in a Rat Model of Cerebral Hypoxia-Ischemia. ( 27885575 )
2017
9
The relationship between the Trendelenburg position and cerebral hypoxia inpatients who have undergone robot-assisted hysterectomy and prostatectomy ( 29306241 )
2017
10
Cerebral hypoxia during immediate transition after birth and short term neurological outcome. ( 28472725 )
2017
11
NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia. ( 29046881 )
2017
12
Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage. ( 29044603 )
2017
13
Does cerebral hypoxia facilitate central fatigue? ( 26891346 )
2016
14
The SafeBoosC II randomized trial: treatment guided by near-infrared spectroscopy reduces cerebral hypoxia without changing early biomarkers of brain injury. ( 26679155 )
2016
15
Translational challenge models in support of efficacy studies: effect of cerebral hypoxia on cognitive performances in rodents. ( 27189464 )
2016
16
Application of a novel rectal cooling device in hypothermia therapy after cerebral hypoxia-ischemia in rats. ( 27613331 )
2016
17
Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells. ( 27724968 )
2016
18
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia. ( 26325524 )
2015
19
Genetic deletion of neuronal pentraxin 1 expression prevents brain injury in a neonatal mouse model of cerebral hypoxia-ischemia. ( 25554688 )
2015
20
Poloxamer 188 Attenuates Cerebral Hypoxia/Ischemia Injury in Parallel with Preventing Mitochondrial Membrane Permeabilization and Autophagic Activation. ( 25966641 )
2015
21
Neuronal death after perinatal cerebral hypoxia-ischemia: Focus on autophagy-mediated cell death. ( 26225751 )
2015
22
Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia. ( 26355725 )
2015
23
Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia. ( 26437227 )
2015
24
Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral hypoxia-ischemia. ( 25627141 )
2015
25
Cerebral hypoxia-ischemia causes cardiac damage in a rat model. ( 24840931 )
2014
26
Therapeutic benefits of delayed lithium administration in the neonatal rat after cerebral hypoxia-ischemia. ( 25211332 )
2014
27
Cerebral hypoxia-ischemia increases toll-like receptor 2 and 4 expression in the hippocampus of neonatal rats. ( 25530127 )
2014
28
Cerebral hypoxia immediately following delivery of very low birth weight infants. ( 24393297 )
2014
29
Simulating NIRS and MRS measurements during cerebral hypoxia-ischaemia in piglets using a computational model. ( 24729232 )
2014
30
A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia. ( 24878681 )
2014
31
Cerebral hypoxia, missing cortical somatosensory evoked potentials and recovery of consciousness. ( 24720818 )
2014
32
The impact of Ly6Clow monocytes after cerebral hypoxia-ischemia in adult mice. ( 24780898 )
2014
33
Catatonia After Cerebral Hypoxia: Do the Usual Treatments Apply? ( 25262046 )
2014
34
Evaluation of 2-[A^a8,F]fluoroacetate kinetics in rodent models of cerebral hypoxia-ischemia. ( 24517980 )
2014
35
Pathology of the right ventricle: a comparison between traumatic brain injury, afterload mismatch and cerebral hypoxia. ( 23375752 )
2013
36
Subacute zinc administration and L-NAME caused an increase of NO, zinc, lipoperoxidation, and caspase-3 during a cerebral hypoxia-ischemia process in the rat. ( 23997853 )
2013
37
Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. ( 23593189 )
2013
38
Cerebral hypoxia in a cat following pharyngoscopy involving use of a mouth gag. ( 22924887 )
2013
39
Erythropoietin: a neuroprotective agent in cerebral hypoxia, neurodegeneration, and epilepsy. ( 23530506 )
2013
40
Targeted drug delivery to treat pain and cerebral hypoxia. ( 23343976 )
2013
41
Brain mitochondrial oxidative metabolism during and after cerebral hypoxia-ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy. ( 23959202 )
2013
42
Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia. ( 22534064 )
2012
43
Cognitive decline in moyamoya: influence of chronic cerebral hypoxia, history of stroke, or comorbid conditions? ( 22171927 )
2012
44
An angiogenic role for the I+5I^1 integrin in promoting endothelial cell proliferation during cerebral hypoxia. ( 22721769 )
2012
45
Use of serum biomarkers to predict cerebral hypoxia after severe traumatic brain injury. ( 22360297 )
2012
46
Chronic cerebral hypoxia promotes arteriogenic remodeling events that can be identified by reduced endoglin (CD105) expression and a switch in I^1 integrins. ( 22739620 )
2012
47
Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigs. ( 22297457 )
2012
48
Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets. ( 22911847 )
2012
49
The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia. ( 22761937 )
2012
50
Tin protoporphyrin provides protection following cerebral hypoxia-ischemia: involvement of alternative pathways. ( 21538467 )
2011

Variations for Cerebral Hypoxia

Expression for Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for Cerebral Hypoxia

Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 BCAR1 CAMK4 CASP3 CASP9 CREB1 IGF1
2
Show member pathways
13.94 CAMK4 CASP3 CASP9 CREB1 FOS ITGAV
3
Show member pathways
13.79 CASP3 CASP9 CREB1 FOS IGF1 ITGAV
4
Show member pathways
13.71 BCAR1 CASP3 CASP9 CREB1 FOS IGF1
5
Show member pathways
13.64 BCAR1 CAMK4 CREB1 FOS IGF1 ITGAV
6
Show member pathways
13.31 CASP3 CASP9 CREB1 FOS IGF1 ITGAV
7
Show member pathways
13.28 BCAR1 CASP3 CREB1 FOS ITGAV ITGB1
8
Show member pathways
13.26 BCAR1 IGF1 ITGAV ITGB1 NOS1 PTK2
9
Show member pathways
13.24 CASP3 CASP9 FOS IGF1 PTK2
10
Show member pathways
12.96 BCAR1 CAMK4 CASP3 FOS IGF1 PTK2
11
Show member pathways
12.96 BCAR1 CAMK4 CREB1 IGF1 ITGAV ITGB1
12
Show member pathways
12.95 FOS IGF1 ITGAV ITGB1 PTK2
13
Show member pathways
12.89 BCAR1 FOS ITGAV ITGB1 NOS1 PTK2
14
Show member pathways
12.87 BCAR1 FOS IGF1 ITGB1 PTK2
15
Show member pathways
12.86 BCAR1 FOS IGF1 ITGAV ITGB1 PTK2
16
Show member pathways
12.86 CASP3 CASP9 CREB1 IGF1 ITGAV ITGB1
17
Show member pathways
12.77 CASP3 CASP9 FOS IGF1
18
Show member pathways
12.75 CAMK4 CASP9 CREB1 IGF1
19
Show member pathways
12.75 CAMK4 CREB1 FOS ITGAV ITGB1 PTK2
20
Show member pathways
12.74 BCAR1 CASP3 CASP9 CREB1 FOS IGF1
21
Show member pathways
12.73 CAMK4 CREB1 FOS NOS1
22 12.72 CASP3 CASP9 FOS IGF1
23 12.7 CASP3 CASP9 FOS IGF1 ITGAV ITGB1
24
Show member pathways
12.6 BCAR1 ITGAV ITGB1 PTK2
25 12.59 BCAR1 ITGAV ITGB1 PTK2
26
Show member pathways
12.58 CASP9 FOS ITGB1 NOS1 PTK2
27
Show member pathways
12.56 CREB1 FOS IGF1 NOS1 PTK2
28
Show member pathways
12.54 BCAR1 CASP9 IGF1 PTK2
29
Show member pathways
12.54 CASP3 CASP9 CREB1 FOS
30
Show member pathways
12.51 CAMK4 CREB1 FOS NOS1
31
Show member pathways
12.47 CASP3 CREB1 FOS ITGB1 PTK2
32
Show member pathways
12.46 CAMK4 CASP3 CASP9 FOS PTK2
33
Show member pathways
12.42 CASP3 CASP9 ITGAV ITGB1 PTK2
34
Show member pathways
12.4 BCAR1 CASP3 CASP9 CREB1 FOS ITGAV
35
Show member pathways
12.39 CAMK4 CASP3 CASP9 CREB1 FOS NOS1
36
Show member pathways
12.38 CASP9 CREB1 FOS IGF1
37
Show member pathways
12.38 CASP9 CREB1 FOS ITGAV PTK2
38
Show member pathways
12.35 CASP3 CASP9 CREB1 IGF1
39
Show member pathways
12.35 BCAR1 CASP9 FOS PTK2
40
Show member pathways
12.32 CAMK4 CASP3 CASP9 CREB1 FOS ITGAV
41
Show member pathways
12.28 BCAR1 CASP3 CASP9 FOS IGF1 ITGB1
42
Show member pathways
12.25 CAMK4 CREB1 FOS
43 12.25 CASP3 IGF1 ITGAV ITGB1 PTK2
44
Show member pathways
12.24 CASP3 CASP9 FOS ITGB1
45
Show member pathways
12.22 CASP3 CASP9 FOS
46 12.2 CASP3 CASP9 CREB1
47
Show member pathways
12.19 ITGAV ITGB1 PTK2
48
Show member pathways
12.18 IGF1 ITGAV ITGB1
49 12.18 BCAR1 CREB1 FOS PTK2
50
Show member pathways
12.17 BCAR1 ITGAV ITGB1 PTK2

GO Terms for Cerebral Hypoxia

Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 9.33 BCAR1 ITGB1 PTK2
2 integrin complex GO:0008305 9.26 ITGAV ITGB1
3 focal adhesion GO:0005925 9.26 BCAR1 ITGAV ITGB1 PTK2
4 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.62 IGF1 ITGAV

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.92 IGF1 ITGAV ITGB1 PTK2
2 positive regulation of transcription, DNA-templated GO:0045893 9.88 CAMK4 CREB1 FOS IGF1 NOS1
3 extracellular matrix organization GO:0030198 9.82 ITGAV ITGB1 PTK2
4 cell migration GO:0016477 9.81 BCAR1 ITGAV ITGB1
5 response to lipopolysaccharide GO:0032496 9.81 CASP3 CASP9 FOS
6 positive regulation of apoptotic process GO:0043065 9.81 CASP3 CASP9 CREB1 ITGB1
7 aging GO:0007568 9.79 CASP9 CREB1 FOS
8 response to hypoxia GO:0001666 9.79 CASP3 CREB1 NOS1
9 response to organic cyclic compound GO:0014070 9.73 CASP3 CASP9 FOS
10 positive regulation of cell migration GO:0030335 9.67 BCAR1 IGF1 ITGAV PTK2
11 response to antibiotic GO:0046677 9.64 CASP3 CASP9
12 ERK1 and ERK2 cascade GO:0070371 9.63 IGF1 ITGAV
13 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.63 BCAR1 ITGAV PTK2
14 positive regulation of cardiac muscle hypertrophy GO:0010613 9.61 IGF1 PTK2
15 heterotypic cell-cell adhesion GO:0034113 9.6 ITGAV ITGB1
16 positive regulation of osteoclast differentiation GO:0045672 9.59 CREB1 FOS
17 platelet formation GO:0030220 9.58 CASP3 CASP9
18 cell-substrate adhesion GO:0031589 9.58 ITGAV ITGB1
19 cell adhesion mediated by integrin GO:0033627 9.57 ITGAV ITGB1
20 negative regulation of anoikis GO:2000811 9.55 ITGB1 PTK2
21 neurotrophin TRK receptor signaling pathway GO:0048011 9.54 BCAR1 CASP3
22 cellular response to hepatocyte growth factor stimulus GO:0035729 9.52 BCAR1 CREB1
23 protein kinase B signaling GO:0043491 9.5 CASP9 CREB1 IGF1
24 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.49 CASP3 CASP9
25 response to cobalt ion GO:0032025 9.43 CASP3 CASP9
26 execution phase of apoptosis GO:0097194 9.43 CASP3 CASP9 PTK2
27 glial cell apoptotic process GO:0034349 9.4 CASP3 CASP9
28 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.33 CASP3 CASP9 ITGAV
29 transforming growth factor beta receptor signaling pathway GO:0007179 9.26 CREB1 FOS ITGB1 PTK2
30 integrin-mediated signaling pathway GO:0007229 8.92 BCAR1 ITGAV ITGB1 PTK2

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.43 IGF1 ITGAV ITGB1
2 fibronectin binding GO:0001968 9.37 ITGAV ITGB1
3 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190 9.32 CREB1 FOS
4 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.16 CASP3 CASP9
5 protease binding GO:0002020 9.13 CASP3 ITGAV ITGB1
6 C-X3-C chemokine binding GO:0019960 8.62 ITGAV ITGB1

Sources for Cerebral Hypoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....