Cerebral Infarction malady

Wikipedia: A cerebral infarction is an ischemic stroke resulting from a disturbance in the blood vessels supplying...⁴⁴ more...

MalaCards: Cerebral Infarction, also known as cerebral infarction nos (disorder), is related to cerebrovascular accident and antithrombin iii deficiency. An important gene associated with Cerebral Infarction is CD59 (CD59 molecule, complement regulatory protein), and among its related pathways are Extrinsic Prothrombin Activation Pathway and Complement and coagulation cascades. The drugs dantrolene sodium and heparin and the compounds glucose and aprotinin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and kidney, and related mouse phenotypes are respiratory system and hematopoietic system.

OMIM: 601367

Aliases & Descriptions:

cerebral infarction 6 33 32 43 cerebral infarction nos (disorder) 6 cva - cerebral infarction 6

cerebrovascular accident 43 cerebral infarction nos 6 cerebral infarct 6

Diseases related to cerebral infarction by text searches and GeneDecks gene sharing:

(show top 50)    (show all 974)

id	Related Disease	Score	Top Affiliating Genes
1	cerebrovascular accident	31.5	COG2, VWF, SELP, SERPINC1, SERPINE1, VEGFA
2	antithrombin iii deficiency	31.3	SERPINC1, SERPIND1, MTHFR, FGA, APOH, F5
3	atherosclerosis	30.5	LCAT, MMP3, ESR1, TNFSF4, TLR4
4	protein c deficiency	30.3	SERPINC1, SERPIND1, SERPINE1, MTHFR, FGA, APOH
5	transient cerebral ischemia	30.2	MTHFR, FGA, APOH, NOTCH3
6	sneddon syndrome	30.1	SERPINC1, APOH, F5, F2, PF4
7	thrombophilia	29.9	VWF, SELP, SERPINC1, SERPIND1, SERPINE1, MTHFR
8	thrombosis	29.8	MTHFR, FGB, F5, F2
9	homocystinuria	29.7	SERPINC1, MTHFR, F5, ALB, CBS, OTC
10	myocardial infarction	29.6	LGALS2, ESR1, TNFSF4, LTA, ACE, THBD
11	acute lymphoblastic leukemia	29.3	COG2, SERPINC1, MTHFR, CD59, CD34, ITGB2
12	cerebral hypoxia	29.0	BMP7, APP, CREB1, PLAT, NOS1
13	tetralogy of fallot	28.6	MTHFR, MMP3, MMP9, IL6, APOE, ENO2
14	antiphospholipid syndrome	28.5	VWF, SELP, SERPINC1, SERPINE1, VEGFA, LDLR
15	hepatitis	28.1	RBP4, SELP, GSR, IL2RB, IFNA1, F2
16	diabetic ketoacidosis	27.5	VWF, INS, IL10, IL6, F5, ICAM1
17	cerebral artery occlusion	27.4	SELP, SERPINE1, VEGFA, MMP9, IL16, IL1RN
18	brain ischemia	27.2	SELP, VEGFA, AQP4, APP, MAP2, HSPA4
19	hemophilia	26.7	VWF, SELP, SERPINC1, MTHFR, IL10, IL1B
20	brain edema	26.6	SERPINE2, VEGFA, MMP9, IL1B, IL1RN, IL6
21	cerebritis	26.3	COG2, NCF1, VWF, RBP4, SELP, SERPINE2
22	hemochromatosis	26.1	INS, IL6, APOE, F5, F2, ALB
23	type 2 diabetes mellitus	26.1	COG2, VWF, RBP4, SELP, SERPINE1, LPA
24	hyperhomocysteinemia	26.0	VWF, SELP, SERPINC1, SERPINE1, LPA, LCAT
25	retinol binding protein	25.9	RBP4, LPA, LIPC, INS, APOA1, APOC2
26	systemic lupus erythematosus	25.5	VWF, RBP4, CD59, ITGB2, MMP3, FGA
27	atrial fibrillation	25.2	VWF, SELP, SERPINC1, SERPINE1, LPA, MTHFR
28	traumatic brain injury	24.1	SERPINC1, VEGFA, MTHFR, MMP3, MMP9, INS
29	seizures	22.0	VEGFA, PAFAH1B1, MTHFR, MMP9, INS, GSTM1
30	brain injury	21.3	VWF, SELP, SERPINC1, SERPINE1, VEGFA, BMP7
31	lymphoblastic leukemia	20.5	COG2, VWF, SELP, SERPINC1, SERPINE1, VEGFA
32	neuronitis	20.0	VWF, SELP, SERPINE2, SERPINC1, SERPINE1, VEGFA
33	homocysteine	20.0	COG2, NCF1, VWF, SELP, SERPINC1, SERPINE1
34	vasculitis	19.6	VWF, SELP, SERPINC1, VEGFA, CD8A, ITGB2
35	hypertension	19.5	COG2, VWF, RBP4, SELP, SERPINC1, SERPINE1
36	lupus erythematosus	19.4	COG2, VWF, RBP4, SELP, SERPINC1, SERPIND1
37	ischemia	19.0	COG2, VWF, SELP, SERPINC1, SERPINE1, VEGFA
38	dementia	18.5	VWF, SELP, SERPINC1, SERPINE1, VEGFA, LPA
39	diabetes mellitus	18.3	COG2, VWF, RBP4, SELP, SERPINC1, SERPINE1
40	cholesterol	16.5	COG2, VWF, RBP4, SELP, SERPINC1, SERPINE1
41	leukemia	15.9	COG2, VWF, RBP4, SELP, SERPINC1, SERPINE1
42	thrombotic thrombocytopenic purpura, acquired	14.3	VWF, SELP, SERPINE1, APOH, F3, PPBP
43	venous thrombosis	14.3	VWF, SELP, SERPINC1, SERPINE1, MTHFR, ITGB2
44	arterial occlusive disease	14.3	VWF, SELP, MTHFR, F3, CBS, PLAT
45	hemorrhagic disease	14.2	VWF, SERPINC1, F5, F3, F2, PPBP
46	catastrophic antiphospholipid syndrome	14.2	SERPINE1, MTHFR, APOH, F5, F3, PROC
47	purpura fulminans	14.2	SERPINC1, MTHFR, APOH, F5, F3, F2
48	blood platelet disease	14.2	VWF, SELP, SERPINC1, F3, PF4
49	bleeding diathesis due to gnaq deficiency	14.2	VWF, SERPINC1, SERPINE1, GP1BA, F5, F3
50	patent foramen ovale	14.1	SERPINC1, MTHFR, FGA, APOH, F5, F2

Clinical features from OMIM: 601367

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dantrolene, dantrolene sodium, heparin, heparin calcium, heparin sodium, heparin sodium (beef lung), heparin sodium (beef), heparin sodium (pork), pentoxifylline

Cell-based therapeutics:

MalaCards organs/tissues related to cerebral infarction:

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MGI Mouse Phenotypes related to cerebral infarction:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	NOS1, CYBA, TBXA2R, TNFRSF4, F13A1, CBS
2	hematopoietic system phenotype	MP:0005397	10.1	FGF2, ITGA2, CD34, CD8A, MYD88, SERPIND1
3	embryogenesis phenotype	MP:0005380	10.1	PROCR, EDN3, COMT, CREB1, NRG1, CBS
4	endocrine/exocrine gland phenotype	MP:0005379	10.0	LTA, NRG1, OTC, IL2RB, IL2, LDLR
5	renal/urinary system phenotype	MP:0005367	9.2	AGTR1, AGT, ABCA1, EDNRA, NOTCH3, NOS3
6	nervous system phenotype	MP:0003631	8.3	MYD88, SERPINC1, SERPINE2, SELP, VWF, BMP7
7	immune system phenotype	MP:0005387	8.2	PLAT, APOA1, IL6, IL2, MMP3, CD34
8	liver/biliary system phenotype	MP:0005370	8.1	NOS3, PLG, OTC, TNFRSF4, CBS, APOB
9	digestive/alimentary phenotype	MP:0005381	7.8	VWF, GDNF, NPY, NPR2, TGFB1, CTGF
10	growth/size phenotype	MP:0005378	7.7	GFAP, AGTR1, AGT, HFE, ACE, ABCA1
11	skeleton phenotype	MP:0005390	7.6	NPR2, INS, MMP9, MMP3, ITGB2, MTHFR
12	adipose tissue phenotype	MP:0005375	6.5	NR3C1, NOS1, NOS2, NOS3, ACE, AGT
13	tumorigenesis	MP:0002006	6.0	NOTCH3, NOS2, PLG, PPARG, PTGS2, RHOB
14	vision/eye phenotype	MP:0005391	5.4	CSF1, NRG1, PPARG, CTGF, PTGS2, TNF
15	cardiovascular system phenotype	MP:0005385	2.4	GDNF, HGF, ADIPOQ, ADM, ENTPD1, INS
16	other phenotype	MP:0005395	INF	NOS2, NOS3, ABCA1, CSF1, ADM, NOS1
17	cellular phenotype	MP:0005384	INF	OTC, GP1BA, CCL5, ENO2, AOC3,
18	reproductive system phenotype	MP:0005389	INF	GDNF, ADIPOQ, TBXA2R, PTGS2, TNF, CBS
19	homeostasis/metabolism phenotype	MP:0005376	INF	ADIPOQ, ADM, KNG1, CPB2, NPY, NPR2
20	integument phenotype	MP:0010771	INF	F3, SELP, F5, , IL4, IL2RB
21	normal phenotype	MP:0002873	INF	CREB1, NR3C1, PPARG, CTGF, CYP1A1, PTGS2
22	muscle phenotype	MP:0005369	INF	GDNF, ADIPOQ, ADM, NPR2, CST3, CSF1
23	mortality/aging	MP:0010768	INF	PLG, F2, F3, F5, F7, MAP2
24	behavior/neurological phenotype	MP:0005386	INF	NR3C1, IL2RB, IL2, IL10, GSTM1, INS
25	no phenotypic analysis	MP:0003012	INF	, F7, ESR1, TNFRSF4, PTGS2, CYP1A1

Articles related to cerebral infarction:

(show top 50)    (show all 221)

id	Title	Authors	Year	Affiliating Genes
1	Circulating apoptotic factors in patients with acute cerebral infarction. (20347759)	Lin C.H.... Sun M.C.	2010	CASP7
2	Role of bradykinin and catecholamines in cerebral infarction and brain edema. (19265042)	Tsuda K.	2009	KNG1
3	The effects of antiplatelet agents on platelet-leukocyte aggregations in patients with acute cerebral infarction. (18188511)	Cao Y.J.... Liu C.F.	2009	SELP
4	Relationship of polymorphism of SG13S114A/T in ALOX5 AP gene with atherosclerotic cerebral infarction (20014490)	He Y.L.... Zhou Y.L.	2009	ALOX5AP
5	Meta-analysis of the ACE gene polymorphism in cerebral infarction. (19294883)	Tao H.M.... Chen G.Z.	2009	ACE
6	Marburg I polymorphism of Factor VII-activating prot ease and cerebral infarction (20045910)	Tan Q.... Chen F.	2009	HABP2
7	C-reactive protein and aetiological subtypes of cerebral infarction. (18810599)	Terruzzi A.... Camerlingo M.	2008	CRP
8	Polymorphism of apolipoprotein A5 is a risk factor for cerebral infarction in type 2 diabetes. (19107359)	Li X.... Niu L.	2008	APOA5
9	Expression and activity of membrane surface tissue factor in peripheral blood cells of patients with cerebral infarction (19099647)	Huang X.L.... Xie Y.P.	2008	F3
10	Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject. (18484194)	Fu Z.... Ma Y.	2008	CYP4A11
11	Association between Val/Leu(247) polymorphism of apolipoprotein H and cerebral infarction in a Chinese population. (18777117)	Xia J.... Yang Q.D.	2008	APOH
12	Association of matrix metalloproteinase-3 serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction. (19065524)	Huang X.... Ye Z.	2008	MMP3
13	The relationship of P47phox C923T (Ala308Val) polymorphism to cerebral infarction and its effect on plasma lipid levels (17925180)	Huang X.S.... Huang Q.	2007	NCF1
14	Early diagnostic significance and dynamic pattern of DWI compared with conventional MRI in newborns with neonatal cerebral infarction (17697623)	Fu J.H.... You K.	2007	CRP
15	The linkage disequilibrium of four loci in hepatic lipase promoter gene of cerebral infarction patients in Shanghai (18001531)	Fu Y.... Chen S.D.	2007	LIPC
16	The kinetic change of the serum angiogenin level in patients with acute cerebral infarction. (17823536)	Huang L.... Jin X.	2007	ANG
17	Diacylglycerol kinase zeta is involved in the process of cerebral infarction. (16553606)	Nakano T.... Goto K.	2006	DGKB, DGKZ, MAP2
18	Human serum paraoxonase gene polymorphisms, Q192R and L55M, are not associated with the risk of cerebral infarction in Chinese Han population. (16808888)	Huang Q.... Liu Z.J.	2006	PON1
19	The prediction of malignant cerebral infarction by mo lecular brain barrier disruption markers. (16100032)	Serena J.... DA!valos A.	2005	MMP9
20	Candidate genes of cerebral infarction and traditional classification in Koreans with cerebral infarction. (16019571)	Um J.Y.... Hong S.H.	2005	ACE, APOE, AGT
21	Association study of apolipoprotein e gene polymorphism and cerebral infarction in type 2 diabetic patients (15730956)	Zhou J.... Zhang J.C.	2005	APOE
22	Effect of erigeron injection on platelet level of CD62p and serum content of TNF-alpha and IL-6 in patients with acute cerebral infarction (15892276)	Wang J.L.... Tan F.	2005	SELP
23	TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction. (15521922)	Akatsu H.... Okada H.	2004	CPB2
24	Thrombomodulin Ala455Val Polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study. (15574195)	Cole J.W.... Kittner S.J.	2004	THBD
25	Strong correlation between the prevalence of cerebral infarction and the presence of anti-cardiolipin/beta2-glycoprotein I and anti-phosphatidylserine/prothrombin antibodies--Co-existence of these antibodies enhances ADP-induced platelet activation in vitro. (15116258)	Nojima J.... Kanakura Y.	2004	F2
26	Tumor necrosis factor alpha gene polymorphism is associated with cerebral infarction. (14992821)	Um J.Y.... Kim H.M.	2004	TNF
27	Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction. (14566994)	Luo B.Y.... Pan X.P.	2003	APOE
28	TNF-alpha and TNF-beta gene polymorphisms in cerebral infarction. (14593215)	Um J.Y.... Kim H.M.	2003	TNF, LTA
29	Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. (12891667)	Dore S.... Andreasson K.	2003	PTGS2
30	Gene therapy and neuroprotection for cerebral infarction (15152496)	Abe K.	2003	GDNF
31	Angiotensin converting enzyme gene polymorphism and traditional Sasang classification in Koreans with cerebral infarction. (14641479)	Um J.Y.... Kim H.M.	2003	ACE
32	Coagulation and fibrinolytic activity in patients with acute cerebral infarction. (12781064)	Li F.... Zhao W.	2003	PLAT, SERPINE1
33	Expression of urokinase-type plasminogen activator and its receptor in plasma of patients with cerebral infarction (14642114)	Song S.J.... Huang J.Z.	2003	PLAUR
34	Association of interleukin-1 alpha gene polymorphism with cerebral infarction. (12824054)	Um J.Y.... Kim H.M.	2003	IL1B, IL1A, IL1RN
35	Relation of pentanucleotide repeat polymorphism of apolipoprotein (a) gene to plasma lipoprotein (a) level among Chinese patients with myocardial infarction and cerebral infarction (12509922)	Liu X.... Hui R.	2002	APOA1, LPA
36	Targets of treatment in the acute phase of cerebral infarction (12235793)	Tanaka K.... Kosakai A.	2001	CREB1
37	The relationship between angiotensin converting enzyme gene polymorphism and risk factors for cerebral infarct (11851058)	Zhang X.... Jin D.	2001	ACE
38	Blood platelet activation markers in patients with acute cerebral infarction during the earliest stage of the disease--evaluation using flow cytometry methods (11253475)	Belniak-LegieA8 E.... Stelmasiak Z.	2000	SELP
39	A case of intravascular malignant lymphomatosis presenting as cerebral infarction (11127588)	Satow T.... Hayashino Y.	2000	IL2RB
40	'Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions'. (10900360)	Postler E.... Meyermann R.	2000	AIF1
41	Brain SPECT imaging using three different tracers in subacute cerebral infarction. (9596150)	Hashimoto J.... Fukuuchi Y.	1998	TSPO
42	Lipoprotein(a) and other risk factors for cerebral infarction. (8567315)	Konemori G.	1995	APOA1, APOB
43	Changes of the plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in cerebral infarction induced by the venous occlusion (8531402)	Wakamatsu S.... Oguri T.	1995	SERPINE1, PPBP, PF4
44	Hemorrhagic cerebral infarction at the old age in a case with familial antithrombin III (ATIII) deficiency (7781225)	Okuyama H.... Yamazaki R.	1995	SERPINC1
45	Protein-losing enteropathy and cerebral infarction associated with systemic lupus erythematosus (8146730)	Murao S.... Yamana S.	1994	ALB
46	Anticardiolipin antibodies and cerebral infarction. (8126523)	Muir K.W.... Alwan W.	1994	APOH
47	Serum neurone specific enolase (NSE) levels as an indicator of neuronal damage in patients with cerebral infarction. (1752289)	Cunningham R.T.... Buchanan K.D.	1991	ENO2
48	Immunohematologic characteristics of infection-associated cerebral infarction. (1866745)	Ameriso S.F.... Fisher M.	1991	SERPINE1, APOH
49	Neuropsychiatric lupus erythematosus, cerebral infarctions, and anticardiolipin antibodies. (2317112)	Fields R.A.... Bankhurst A.D.	1990	APOH
50	t-PA activity, antigen and PAI-1 antigen levels in blood obtained from the patients with cerebral infarction (2119465)	Yamada S.... Watanabe S.	1990	PLAT

Genes related to cerebral infarction according to GeneCards:

(show top 50)    (show all 159)

id	Symbol	Description	Score	GeneCards Section Context
1	CD59	CD59 molecule, complement regulatory protein	11.1	Summaries
2	PRKCH	protein kinase C, eta	11.0	Publications
3	SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	11.0	Publications
4	AIF1	allograft inflammatory factor 1	11.0	Publications
5	FTMT	ferritin mitochondrial	11.0
6	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	11.0	Publications
7	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
8	PF4	platelet factor 4	11.0	Publications
9	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
10	PTGIS	prostaglandin I2 (prostacyclin) synthase	11.0	Publications
11	APOA2	apolipoprotein A-II	11.0	Publications
12	FGA	fibrinogen alpha chain	11.0	Publications
13	AQP4	aquaporin 4	11.0
14	AOC3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	11.0
15	TSPO	translocator protein (18kDa)	11.0	Publications
16	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	11.0	Publications
17	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	11.0
18	NOTCH3	notch 3	11.0
19	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
20	EDN3	endothelin 3	11.0
21	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
22	RHOD	ras homolog family member D	11.0	Publications
23	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
24	PLAT	plasminogen activator, tissue	11.0	Publications
25	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
26	CANT1	calcium activated nucleotidase 1	11.0
27	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
28	THBD	thrombomodulin	11.0	Publications
29	COG2	component of oligomeric golgi complex 2	11.0
30	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
31	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
32	HSPA8	heat shock 70kDa protein 8	11.0	Publications
33	BMP7	bone morphogenetic protein 7	11.0
34	LPA	lipoprotein, Lp(a)	11.0	Publications
35	HSPA4	heat shock 70kDa protein 4	11.0	Publications
36	VWF	von Willebrand factor	11.0	Publications
37	NRG1	neuregulin 1	11.0
38	PDE4D	phosphodiesterase 4D, cAMP-specific	11.0	Publications
39	APOM	apolipoprotein M	11.0	Publications
40	LGALS2	lectin, galactoside-binding, soluble, 2	11.0	Publications
41	FGB	fibrinogen beta chain	11.0	Publications
42	DEFA1	defensin, alpha 1	11.0	Publications
43	TNFRSF4	tumor necrosis factor receptor superfamily, member 4	11.0	Publications
44	DGKZ	diacylglycerol kinase, zeta	11.0	Publications
45	NCF1	neutrophil cytosolic factor 1	11.0	Publications
46	FABP1	fatty acid binding protein 1, liver	11.0	Publications
47	HABP2	hyaluronan binding protein 2	11.0	Publications
48	NPR2	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	11.0	Publications
49	LIPG	lipase, endothelial	11.0	Publications
50	F12	coagulation factor XII (Hageman factor)	11.0	Publications

Pathways related to cerebral infarction according to GeneDecks:

(show top 50)    (show all 97)

id	Pathway	Score	Top Affiliating Genes
1	Extrinsic Prothrombin Activation Pathway36	10.9	PROC, SERPINC1, FGA, FGB, F7, F5
2	Complement and coagulation cascades20	10.8	VWF, SERPINC1, SERPIND1, SERPINE1, CD59, FGA
3	Platelet activation, signaling and aggregation38	10.8	DGKZ, DGKB, PF4, PLG, TBXA2R, APOA1
4	Blood Coagulation Signaling Pathways37	10.8	F12, PLG, THBD, PROC, KNG1, PLAT
5	Blood Coagulation Cascade36	10.7	FGA, FGB, F7, F5, F3, F2
6	Glioma Invasiveness36	10.3	FGF2, ITGB2, BMP7, NRG1, HGF, PLAUR
7	Statin Pathway, Pharmacodynamics34	10.3	LPL, APOE, LDLR, LCAT, APOA1, APOA5
8	RAR-Gamma-RXR-Alpha Degradation36	10.2	CCL11, IL2, IL16, PF4, LTA, CSF1
9	IL-6 Pathway36	9.8	TNFSF4, HGF, CCL5, BMP7, IL10, IL16
10	eNOS Signaling36	9.5	ROS1, BMP7, IL2, AQP4, HGF, NPR2
11	Molecular Mechanisms of Cancer36	9.4	TNFRSF4, LTA, PF4, NRG1, PPBP, CTGF
12	NFAT Signaling and Lymphocyte Interactions36	9.4	BMP7, IL16, IL1A, IL4, IL2, IL2RB
13	PGC1Alpha Pathway36	9.4	IL1A, CREB1, CCL5, CCL11, IL4, BMP7
14	Hematopoietic cell lineage20	9.3	ITGA2, CD8A, HLA-DRB1, GP1BA, IL6, IL4
15	Regulation of eIF4 and p70S6K36	9.3	CCL11, IL6, CCL5, IL2, ITGA2, ITGB2
16	Selected targets of HNF110	9.0	ABCA1, PROC, APOB, INS, APOA1, APOA2
17	Immune response IL-1 signaling pathway10	8.9	EDN1, NOS2, PTGS2, TNF, F3, IL1B
18	Immune response_IL-1 signaling pathway41	8.9	TNF, HMOX1, F3, IL6, PTGS2, IL1B
19	PPAR Pathway36	8.9	LTA, NRG1, TNF, IL6, IL2, FGF2
20	NF-KappaB Family Pathway36	8.8	MYD88, TLR4, LTA, TGFB1, PRKCH, HGF
21	Pertussis20	8.7	CASP7, TNF, NOS2, RHOA, TLR4, IL6
22	NF-KappaB (p50-p65) Pathway36	8.7	LTA, NRG1, PPBP, CTGF, TNF, MYD88
23	Endothelin-1 Signaling Pathway36	8.7	IL1A, IL4, IL2, IL1B, IL16, IL10
24	Malaria20	8.6	IL1B, TGFB1, HGF, TNF, ICAM1, IL6
25	Akt Signaling36	8.5	NRG1, CTGF, PF4, LTA, CSF1, ROS1
26	Rheumatoid arthritis20	8.5	IL6, ITGB2, VEGFA, MMP3, IL1A, IL1B
27	Rho Family GTPases36	8.5	BMP7, ITGA2, ITGB2, IL10, IL16, LTA
28	ERK Signaling36	8.4	PRKCH, IL1A, IL1B, TNFSF4, IL2, IL4
29	PEDF Induced Signaling36	8.3	PF4, TNFSF4, TNF, CASP7, CCL5, CCL11
30	STAT3 Pathway36	8.3	IL2, IL1B, IL1A, IL16, IL10, LTA
31	TGF-Beta Pathway36	8.3	IL1A, CCL5, CCL11, IL6, IL4, IL2RB
32	Chagas disease (American trypanosomiasis)20	8.3	IL10, TGFB1, SERPINE1, TLR4, IL1B, MYD88
33	Immune response MIF-mediated glucocorticoid regulation10	8.3	NOS2, NR3C1, TNF, ICAM1, IL6, IL2
34	Glucocorticoid Receptor Signaling36	8.2	IL2, IL1B, IL1A, IL2RB, IL16, IL10
35	Cytokine Network36	8.2	TNF, IFNA1, IL6, IL4, IL2, IL1B
36	Antioxidant Action of Vitamin-C36	8.1	HGF, CSF1, PRKCH, TGFB1, IL1A, IL6
37	Leishmaniasis20	8.1	NOS2, TLR4, CYBA, PTGS2, NCF1, MYD88
38	PAK Pathway36	8.0	NRG1, PPBP, CTGF, TNFSF4, CASP7, CCL5
39	p38 Signaling36	8.0	HGF, IL1A, IL16, IL10, FGF2, BMP7
40	Tuberculosis20	8.0	ITGB2, IL1A, IL6, IL1B, MYD88, IL10
41	Immune response_MIF-mediated glucocorticoid regulation41	8.0	IL2, IL6, ICAM1, TNF, PTGS2, NR3C1
42	all-trans-Retinoic Acid Signaling in Brain36	7.9	HGF, CSF1, IL1B, LTA, PF4, PTGS2
43	Tec Kinases Signaling36	7.8	IL6, IL4, TLR4, TGFB1, PRKCH, HGF
44	MAPK Family Pathway36	7.8	IL4, CTGF, CCL5, HGF, BMP7, FGF2
45	MIF Regulation of Innate Immune Cells36	7.8	HGF, CSF1, TLR4, LTA, PF4, PTGS2
46	JAK-STAT Pathway36	7.8	AGTR1, IL6, IFNA1, CCL5, CCL11, IL4
47	MIF Mediated Glucocorticoid Regulation36	7.7	PF4, NR3C1, PTGS2, TNFSF4, TNF, CCL5
48	Cytokine-cytokine receptor interaction20	7.6	IL4, CCL11, PF4, CCL5, IFNA1, TNF
49	SOCS Pathway36	7.5	BMP7, IL4, INS, FGF2, IL10, IL16
50	DHA Signaling36	INF	BMP7, FGF2, IL1B, IL2, , CASP7

Compounds related to cerebral infarction according to GeneDecks:

(show top 50)    (show all 506)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.8	BMP7, P2RY2, ITGA2, GP1BA, OTC, CTGF
2	aprotinin32 9 9	12.6	VWF, SELP, SERPINC1, MMP9, FGA, IL1A
3	ticlopidine32 9 9	12.5	VWF, SELP, SERPINC1, FGA, APOH, F3
4	dmso32	10.5	SELP, MMP3, APOB, MAP2, F3, ALOX5AP
5	adp32 18	11.4	VWF, SELP, SERPINC1, LPA, CHKA, P2RY2
6	cholesterol ester32	10.3	COG2, LPA, LPL, LIPC, LDLR, LCAT
7	txb232	10.2	VWF, SELP, LPA, PAFAH1B1, FGA, IL1RN
8	iloprost32 42 9 9	13.2	SELP, SERPINC1, F3, PTGS2, PPBP, PLAT
9	fatty acid32	10.2	COG2, RBP4, MYD88, LIPG, CHKA, LCAT
10	thromboxane a232 18	11.1	VWF, SELP, ITGA2, FGA, APOH, CANT1
11	malondialdehyde32	10.0	COG2, LPA, CHKA, GSR, GSTM1, GSTT1
12	dermatan sulfate32	9.9	VWF, SELP, SERPINC1, SERPIND1, FGF2, APOE
13	probucol32 9 9	11.6	LPL, LIPC, LDLR, LCAT, APOA1, APOB
14	p00232	9.5	RBP4, LPA, LIPC, MTHFR, MMP3, MMP9
15	calcitriol32 42 9 18 9	13.4	BMP7, FGF2, IL2, CCL5, ALB, CREB1
16	l-nmma32	9.4	IL1RN, CAT, PPARG, NOS1, NOS2, EDN1
17	leukotriene b432 42 18	11.2	SELP, PAFAH1B1, ITGB2, MMP9, IL1A, IL1B
18	betacarotene32	9.0	VWF, RBP4, LPL, CHKA, MTHFR, GSR
19	dextran sulfate32	8.9	SELP, SERPINC1, LPL, LDLR, IL6, APOA1
20	bezafibrate32 9 9	10.8	COG2, SERPINE1, LPA, LPL, LIPC, LDLR
21	calcium32 9 18 9	11.7	COG2, VWF, RBP4, SERPINE2, LPA, BMP7
22	perindopril32 34 9 9	11.7	VWF, SERPINE1, VEGFA, ALB, CRP, PLAT
23	oxygen32 18	9.7	RBP4, LIPG, LIPC, CHKA, P2RY2, FTMT
24	streptozotocin32	8.7	LPL, LDLR, INS, APOE, AOC3, CTGF
25	rantes32	8.2	SELP, MYD88, ITGB2, MMP3, MMP9, IL16
26	arachidonic acid32 9 18 9	10.7	VWF, SELP, LPL, LIPG, LIPC, PAFAH1B1
27	fenofibrate32 9 9	9.6	COG2, SELP, SERPINE1, LPA, LPL, LIPC
28	thymidine32 18	8.5	BMP7, CHKA, MTHFR, CD34, FGA, FGF2
29	estrogen32	7.4	COG2, VWF, RBP4, SERPINC1, SERPINE1, LPA
30	prednisolone32 9 9	9.0	VWF, ITGB2, MMP3, GSTM1, FGF2, IL10
31	8-isoprostane32	6.8	SERPINE1, MMP9, INS, IL10, IL6, APOH
32	prostacyclin32	6.4	VWF, SELP, SERPINC1, SERPINE1, VEGFA, LDLR
33	indomethacin32 9 9	7.2	LPL, LDLR, ITGB2, MMP3, GSR, IL1A
34	genistein32 9 18 9	8.0	SELP, SERPINE1, VEGFA, LPL, CHKA, LDLR
35	retinoic acid32 42 18	INF	VWF, RBP4, SELP, SERPINE1, BMP7, CHKA
36	sodium nitroprusside32	INF	VWF, , HSPA4, HSPA8, CAT, HMOX1
37	paclitaxel32 34 9 9	INF	VEGFA, ITGB2, FGF2, IL1A, , MAP2
38	isoproterenol32 9 9	INF	P2RY2, FGF2, IL1A, , HSPA4, CYP1A1
39	arginine32	INF	COG2, VWF, SERPINC1, LPA, LIPC, LDLR
40	corticosterone32 18	INF	FGF2, IL1A, IL1B, IL1RN, , MAP2
41	cholesterol32 9 18 9	INF	COG2, VWF, RBP4, SELP, SERPINE1, LPA
42	egcg32	INF	LDLR, IL1A, , CCL5, CAT, SULT1A3
43	lovastatin32 42 9 9	INF	COG2, LPA, LPL, LIPC, CHKA, LDLR
44	iron32 18	INF	COG2, RBP4, FTMT, CD59, MMP3, IL1RN
45	aspartate32	INF	RBP4, SELP, LDLR, ITGB2, MMP9, GSR
46	lipid32	INF	COG2, RBP4, SERPINE2, SERPINE1, LPA, LPL
47	valine32	INF	RBP4, LPL, MTHFR, GSTM1, GSTT1, APOE
48	aspirin32 34 18	INF	COG2, VWF, SELP, SERPINC1, SERPINE1, LPA
49	heparin32 9 18 9	INF	COG2, VWF, SERPINE2, SERPIND1, SERPINE1, LPA
50	folate32	INF	VWF, RBP4, SERPINC1, LPA, LDLR, MTHFR

Cellular components related to cerebral infarction according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	very-low-density lipoprotein particle	GO:034361	10.5	APOM, APOH, APOE, APOC2, APOB, APOA5
2	high-density lipoprotein particle	GO:034364	10.5	PON1, APOM, APOH, APOE, APOA5, APOA2
3	chylomicron	GO:042627	10.4	APOH, APOE, APOC2, APOB, APOA5, APOA2
4	low-density lipoprotein particle	GO:034362	10.2	PLA2G7, APOM, APOE, APOC2, APOB, APOA5
5	spherical high-density lipoprotein particle	GO:034366	10.1	PON1, APOM, APOC2, APOA2, APOA1
6	external side of plasma membrane	GO:009897	9.2	AQP4, ICAM1, HLA-DRB1, TNF, TNFRSF4, ACE
7	extracellular space	GO:005615	4.0	LTA, F2, F3, ICAM1, F5, F7
8	platelet alpha granule lumen	GO:031093	INF	HGF, VWF, SERPINE1, VEGFA, KNG1, TGFB1
9	plasma membrane	GO:005886	INF	KNG1, ROS1, NPR2, CSF1, SOD1, RHOA
10	extracellular region	GO:005576	INF	APOA2, LCAT, LPL, LPA, VEGFA, SERPINE1
11	integral to plasma membrane	GO:005887	INF	TNFRSF4, TNFSF4, TBXA2R, NRG1, PLAUR, EDNRA
12	cell surface	GO:009986	INF	HSPA8, TNF, TNFRSF4, TNFSF4, PLAT, PLAUR
13	cytosol	GO:005829	INF	COMT, NOTCH3, NOS3, NOS2, NOS1, NR3C1

Biological processes related to cerebral infarction according to GeneDecks:

(show top 50)    (show all 79)

id	Name	GO ID	Score	Top Affiliating Genes
1	reverse cholesterol transport	GO:043691	10.7	APOM, APOE, APOA2, APOA1, APOC2, LCAT
2	high-density lipoprotein particle clearance	GO:034384	10.7	APOM, APOE, APOC2, APOA2, APOA1
3	high-density lipoprotein particle assembly	GO:034380	10.7	APOA2, APOE, APOM, ABCA1, APOA1
4	negative regulation of fibrinolysis	GO:051918	10.7	APOH, F2, PLG, THBD, SERPINE1, CPB2
5	high-density lipoprotein particle remodeling	GO:034375	10.7	APOA2, LIPG, APOE, APOA1, LCAT, APOM
6	fibrinolysis	GO:042730	10.7	CPB2, SERPINE1, PLAUR, PLG, F2, F12
7	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.6	LPL, APOB, PF4, AGT, AGTR1, PRKCH
8	negative regulation of blood coagulation	GO:030195	10.6	SERPINE2, SERPINE1, CD34, APOE, APOH, CYP4F2
9	low-density lipoprotein particle remodeling	GO:034374	10.6	APOA2, AGTR1, PLA2G7, LIPC, APOB, AGT
10	very-low-density lipoprotein particle remodeling	GO:034372	10.6	APOC2, LCAT, APOE, LIPC, LPL
11	positive regulation of cholesterol esterification	GO:010873	10.5	AGTR1, APOA1, APOE, APOA2, AGT
12	cholesterol homeostasis	GO:042632	10.5	ABCA1, APOE, APOC2, APOA5, APOA2, APOA1
13	blood coagulation, intrinsic pathway	GO:007597	10.4	GP1BA, F2, F12, KNG1, VWF, APOH
14	cholesterol efflux	GO:033344	10.4	APOA1, APOA2, APOC2, APOM, ABCA1, APOE
15	organ regeneration	GO:031100	10.2	APOA2, APOA5, ADM, TGFB1, PPARG, APOH
16	positive regulation of inflammatory response	GO:050729	10.1	IL2, TNFSF4, PLA2G7, TLR4, AGTR1, AGT
17	negative regulation of platelet activation	GO:010544	10.1	F2, THBD, SERPINE2, APOE, NOS3
18	positive regulation of immunoglobulin secretion	GO:051024	10.1	RBP4, IL2, IL6, TNFRSF4, TNFSF4
19	negative regulation of smooth muscle cell proliferation	GO:048662	10.0	NOS3, HMOX1, COMT, PPARG, AIF1, ADIPOQ
20	aging	GO:007568	10.0	IL1B, ADM, P2RY2, CCL5, F3, CASP7
21	cholesterol metabolic process	GO:008203	10.0	APOA2, LIPC, ABCA1, TNFSF4, CAT, APOE
22	lipoprotein metabolic process	GO:042157	9.9	ALB, LDLR, LCAT, APOA1, APOA2, APOA5
23	negative regulation of nitric oxide biosynthetic process	GO:045019	9.7	IL4, IL10, CD34, TSPO, PTGIS
24	response to lipopolysaccharide	GO:032496	9.6	PTGS2, F3, IL1A, MMP9, SELP, EDNRA
25	regulation of blood pressure	GO:008217	9.6	CD34, SOD1, HMOX1, PTGS2, ACE, NPR2
26	positive regulation of interleukin-6 production	GO:032755	9.5	IL1A, IL1B, IL6, TNFSF4, TLR4, TNF
27	lipopolysaccharide-mediated signaling pathway	GO:031663	9.5	NOS3, TLR4, TGFB1, IL1B, CCL5, TNF
28	positive regulation of cellular protein metabolic process	GO:032270	9.5	INS, AGT, AGTR1, TGFB1, ADIPOQ, CSF1
29	cellular response to lipopolysaccharide	GO:071222	9.5	TLR4, SERPINE1, IL10, ICAM1, TNFSF4, NOS2
30	lipid metabolic process	GO:006629	9.5	APOA1, APOA2, APOB, APOC2, APOE, ALB
31	positive regulation of angiogenesis	GO:045766	9.5	HMOX1, IL1B, CCL11, CCL5, F3, PTGIS
32	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	CCL5, IL6, TNF, MYD88, AIF1, PTGS2
33	response to organic cyclic compound	GO:014070	9.3	IL1A, IL1RN, CTGF, ENO2, F7, SELP
34	positive regulation of protein phosphorylation	GO:001934	9.1	VEGFA, CTGF, IL1B, F2, AIF1, TNF
35	positive regulation of chemokine biosynthetic process	GO:045080	9.1	TNF, HMOX1, IL4, IL1B, MYD88
36	response to estradiol stimulus	GO:032355	8.9	CTGF, F3, IL1B, MMP9, NOS3, PTGS2
37	positive regulation of apoptotic process	GO:043065	8.7	AGT, NOS3, TLR4, RHOB, PTGS2, TSPO
38	response to glucocorticoid stimulus	GO:051384	8.6	IL1B, SERPINE1, LCAT, IL10, IL1RN, IL6
39	anti-apoptosis	GO:006916	8.4	TNF, HMOX1, NOS3, SOD1, HGF, GDNF
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.3	TGFB1, ICAM1, IL6, INS, IL1B, CAT
41	positive regulation of cell proliferation	GO:008284	8.3	EDNRA, CSF1, EDN3, EDN1, VEGFA, INS
42	inflammatory response	GO:006954	8.2	CYBA, IL6, AOC3, CCL11, CCL5, KNG1
43	positive regulation of nitric oxide biosynthetic process	GO:045429	8.0	AIF1, TLR4, ESR1, ICAM1, TNF, EDN1
44	response to hypoxia	GO:001666	7.9	CAT, ANG, EDN1, IL1B, IL1A, MMP9
45	negative regulation of apoptotic process	GO:043066	7.8	PLAUR, PROC, EDNRA, PF4, SERPINE1, FABP1
46	response to drug	GO:042493	7.5	IL1RN, CCL5, IL4, APOA2, APOC2, ENO2
47	small molecule metabolic process	GO:044281	7.4	CYP1A1, APOA1, APOA2, APOA5, CYP4F2, APOC2
48	platelet activation	GO:030168	INF	ALB, F13A1, TBXA2R, PPBP, PLG, PF4
49	platelet degranulation	GO:002576	INF	F13A1, FGA, VEGFA, SERPINE1, SELP, VWF
50	blood coagulation	GO:007596	INF	TGFB1, THBD, RHOA, PF4, NOS3, NOS2

Molecular functions related to cerebral infarction according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	glycoprotein binding	GO:001948	10.3	APOH, ITGB2, LDLR, SELP, VWF, F7
2	eukaryotic cell surface binding	GO:043499	10.3	ADIPOQ, TGFB1, APOH, FGB, FGA, SELP
3	phospholipid binding	GO:005543	10.0	PON1, ABCA1, PLA2G7, OTC, F3, FABP1
4	antioxidant activity	GO:016209	9.6	CAT, ALB, FABP1, APOM, APOE
5	protease binding	GO:002020	9.2	CST3, TNF, F3, INS, SERPINE1, SERPINC1
6	heme binding	GO:020037	9.1	CYBA, CYP4F2, NOS1, NOS2, NOS3, CYP1A1
7	enzyme binding	GO:019899	8.8	PTGS2, PPARG, PLAUR, NOTCH3, TGFB1, PRKCH
8	protein homodimerization activity	GO:042803	8.2	HMOX1, PTGS2, NR3C1, CRP, NOS2, TGFB1
9	growth factor activity	GO:008083	8.0	PPBP, NRG1, AGT, TGFB1, CSF1, HGF
10	cytokine activity	GO:005125	7.5	TNF, TNFSF4, NRG1, LTA, EDN1, CSF1
11	protein binding	GO:005515	INF	NOTCH3, ADIPOQ, HGF, ADM, CST3, SOD3
12	heparin binding	GO:008201	INF	LIPC, PAFAH1B1, FGF2, APOA5, APOB, APOE
13	receptor binding	GO:005102	INF	SERPINE2, SERPINE1, LPL, ITGB2, FGA, FGB