CM
MCID: CRB021
MIFTS: 59

Cerebral Malaria (CM) malady

Infectious diseases category
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Summaries for Cerebral Malaria

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8Disease Ontology, 47OMIM, 33MalaCards
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Disease Ontology:8 A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by plasmodium species.

MalaCards: Cerebral Malaria, also known as malaria, cerebral, is related to malaria and plasmodium falciparum malaria. An important gene associated with Cerebral Malaria is ICAM1 (intercellular adhesion molecule 1), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drug pentoxifylline and the compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and endothelial, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Description from OMIM:47 611162

Aliases & Classifications for Cerebral Malaria

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8Disease Ontology, 47OMIM, 45Novoseek, 39NCBI Bookshelf, 62UMLS, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

cerebral malaria 8
malaria, cerebral 47 62
malarial encephalitis 8
malaria cerebral 45
cm 39


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Disease Ontology8 DOID:14069
SNOMED-CT58 53622003, 186799006
MeSH35 D016779

Related Diseases for Cerebral Malaria

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1malaria31.8CD36, TNF, TCN2, GYPB, GYPA, ICAM1
2plasmodium falciparum malaria30.3ICAM1, CD36
3systemic lupus erythematosus30.2FCGR3B
4hepatitis30.1HAVCR1, HBE1, CXCL10
5melanoma29.7TNF, CXCL10, ANGPT2, ICAM1, CD36
6cerebritis11.4
7endotheliitis10.6
8hepatocellular carcinoma10.5
9congenital myasthenic syndrome10.4
10neuronitis10.4
11renal cell carcinoma10.4
12retinitis10.3
13chiari malformation10.3
14adenocarcinoma10.2
15insulinoma10.2
16thyroiditis10.2
17chiari malformation type 210.2
18congenital myasthenic syndrome with episodic apnea10.2
19brain edema10.2
20encephalitis10.2
21meningitis10.2
22protein-energy malnutrition10.2
23brain injury10.2
24malaria, cerebral, reduced risk of10.2
25peritonitis10.2
26congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.2
27renal cell carcinoma 410.2
28myasthenic syndrome, fast-channel congenital10.2
29hemoglobinuria10.1TCN2
30hepatitis a10.1HBE1
31leukostasis10.1ICAM1
32rheumatoid vasculitis10.1ICAM1
33papillary carcinoma10.1
34coloboma10.1
35angiomyolipoma10.1
36liver cirrhosis10.1
37lung adenocarcinoma10.1
38lung cancer10.1
39optic atrophy10.1
40papillary thyroid carcinoma10.1
41capillary malformation-arteriovenous malformation syndrome10.1
42slow-channel congenital myasthenic syndrome10.1
43spasticity10.1
44melanocytic nevus syndrome, congenital, somatic10.1
45peritoneal carcinoma10.1
46multicentric reticulohistiocytosis10.1HAVCR1
47mycobacterium avium complex disease10.1IFNGR1
48alpha thalassemia10.1AHSP, HBE1
49asthma10.1IL12B, TNF
50psoriatic arthritis10.1TNF, ANGPT2

Graphical network of the top 20 diseases related to Cerebral Malaria:



Diseases related to cerebral malaria

Symptoms for Cerebral Malaria

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47OMIM
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Clinical features from OMIM:

611162

Drugs & Therapeutics for Cerebral Malaria

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cerebral Malaria

Search NIH Clinical Center for Cerebral Malaria

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Cerebral Malaria

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Anatomical Context for Cerebral Malaria

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33MalaCards
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MalaCards organs/tissues related to Cerebral Malaria:

33
Brain, T cells, Endothelial, Eye, Whole blood, Cortex, B cells, Monocytes, Nk cells, Testes, Liver, Kidney, Heart, Spleen, Temporal lobe

Animal Models for Cerebral Malaria or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cerebral Malaria:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6IL12B, IL12A, IFNGR1, ICAM1, TNF
2MP:00053818.3TNF, ANGPT2, ICAM1, IFNGR1, IL12B, IL9
3MP:00053767.4TNF, CXCL10, ANGPT2, ICAM1, IFNGR1, IL12A
4MP:00107687.1AHSP, TNF, CXCL10, ANGPT2, ICAM1, IFNGR1
5MP:00053976.7CXCL10, TNF, AHSP, HAVCR1, ICAM1, IFNGR1
6MP:00053876.5CD36, HAVCR1, AHSP, TNF, CXCL10, ANGPT2

Publications for Cerebral Malaria

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Sources:
52PubMed
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Articles related to Cerebral Malaria:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Histidine-rich protein 2 plasma levels predict progression to cerebral malaria in Malawian children with Plasmodium falciparum infection. (23630364)
2013
2
Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria. (23890318)
2013
3
Dose responses of proveblue methylene blue in an experimental murine cerebral malaria model. (23669389)
2013
4
Clinical and laboratory predictors of outcome in cerebral malaria in suburban Nigeria. (23949295)
2013
5
Neurocognitive sequelae of cerebral malaria in adults: a pilot study in Benguela Central Hospital, Angola. (23836023)
2013
6
High Plasma Levels of Soluble Intercellular Adhesion Molecule (ICAM)-1 Are Associated with Cerebral Malaria. (24386348)
2013
7
Association of TNF level with production of circulating cellular microparticles during clinical manifestation of human cerebral malaria. (23459075)
2013
8
IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice. (23585679)
2013
9
Neuroleptic malignant syndrome masked by cerebral malaria. (23704432)
2013
10
Neurological sequelae in survivors of cerebral malaria. (24198884)
2013
11
IFN-I^-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. (22723523)
2012
12
Prevalence of raised intracranial pressure in cerebral malaria detected by optic nerve sheath ultrasound. (23033398)
2012
13
Plasmodium berghei ANKA: erythropoietin activates neural stem cells in an experimental cerebral malaria model. (21044627)
2011
14
CD8+ T cells and IFN-I^ mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria. (21494565)
2011
15
Nogo-A expression in the brain of mice with cerebral malaria. (21980529)
2011
16
CXCL4 and CXCL10 predict risk of fatal cerebral malaria. (21508508)
2011
17
Cutting edge: the membrane attack complex of complement is required for the development of murine experimental cerebral malaria. (21572031)
2011
18
The neuropathology of fatal cerebral malaria in malawian children. (21514429)
2011
19
In the eye of experimental cerebral malaria. (21741941)
2011
20
The murine cerebral malaria phenomenon. (19932638)
2010
21
Severe neurological sequelae and behaviour problems after cerebral malaria in Ugandan children. (20398391)
2010
22
Rethinking cerebral malaria pathology. (20613511)
2010
23
Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria. (20454664)
2010
24
Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. (20110412)
2010
25
Fluorescein angiography findings strengthen the theoretical basis for trialling neuroprotective agents in cerebral malaria. (19635680)
2009
26
Severe retinal whitening in an adult with cerebral malaria. (19478242)
2009
27
Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria. (20003529)
2009
28
Retinal pathology of pediatric cerebral malaria in Malawi. (19177166)
2009
29
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
30
Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (18294362)
2008
31
Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. (18347328)
2008
32
Evaluation of alternative diagnostic techniques for diagnosis of cerebral malaria in a tertiary referral hospital in Bangladesh. (18626455)
2008
33
Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. (18644885)
2008
34
Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. (17997848)
2007
35
Glial activation and matrix metalloproteinase release in cerebral malaria. (17454443)
2007
36
Plasmodium vivax cerebral malaria. (17620697)
2007
37
Cerebral malaria is associated with IgG2 and IgG4 antibody responses to recombinant Plasmodium falciparum RIFIN antigen. (16679041)
2006
38
Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. (16500656)
2006
39
Epilepsy as a consequence of cerebral malaria in area in which malaria is endemic in Mali, West Africa. (16686652)
2006
40
Experimental models of cerebral malaria. (16265904)
2005
41
Fulminant cerebral malaria in a Swiss patient. (15750758)
2005
42
Parasite diversity in adult patients with cerebral malaria: a hospital-based, case-control study. (15642966)
2004
43
Differentiating the pathologies of cerebral malaria by postmortem parasite counts. (14745442)
2004
44
Commonly recognised Plasmodium falciparum parasites cause cerebral malaria. (13680376)
2003
45
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. (12421634)
2002
46
Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais. (11719109)
2001
47
Removal of plasma polymorphonuclear leukocyte elastase and TNFalpha in a child with cerebral malaria by means of PD: a case report. (10433165)
1999
48
Inducible nitric oxide synthase polymorphism and fatal cerebral malaria. (9777841)
1998
49
Inhibition of tumour necrosis factor (TNF) production by antimalarial drugs used in cerebral malaria. (7778153)
1995
50
TNF in cerebral malaria. (8483997)
1993

Variations for Cerebral Malaria

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Expression for genes affiliated with Cerebral Malaria

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Malaria

Search GEO for disease gene expression data for Cerebral Malaria.

Pathways for genes affiliated with Cerebral Malaria

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Sources:
50PathCards, 60Thomson Reuters, 54R&D Systems, 53QIAGEN, 38NCBI BioSystems Database, 30KEGG, 55Reactome
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Pathways related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ICAM1, TNF
2
Show member pathways
9.9TNF, IL12A
39.8ICAM1, CD36, TNF
4
Show member pathways
9.7IL12B, TNF
59.7IL12B, TNF
69.6ICAM1, CXCL10, TNF
79.6ICAM1, CXCL10, TNF
89.6IL12A, IL12B
9
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.5IL12B, ANGPT2, TNF
109.4CD36, TNF, GYPA
119.4IFNGR1, TNF, FCGR3B
129.4IL12B, TNF, IL12A
139.4IL12B, IL12A, TNF
149.4TNF, IL12B, IL12A
159.4IL12B, IL12A, TNF
16
Show member pathways
9.3ICAM1, CXCL11, CD36, CXCL10
179.3ICAM1, IFNGR1, CXCL10
189.2IL12A, IL12B, ICAM1, TNF
199.1IL12A, IL12B, IL9, TNF
20
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0TNF, CXCL11, IFNGR1, CXCL10
21
Show member pathways
8.9IL12B, CXCL10, IL12A, TNF
22
Show member pathways
IL27-mediated signaling events38
8.8IL12B, IL12A, IFNGR1, TNF
23
Show member pathways
Type III interferon signaling38
8.8IL12A, IFNGR1, IL12B, IL9
24
Show member pathways
Immune response CD16 signaling in NK cells60
8.8ICAM1, FCGR3B, KIR2DL3, IFNGR1, TNF
25
Show member pathways
8.5IFNGR1, TNF, FCGR3B, IL12A, IL12B
268.5FCGR3B, TNF, IFNGR1, IL12B, IL12A
278.5GYPA, TNF, GYPB, ICAM1, IL12A, CD36
28
Show member pathways
8.3IL12A, ANGPT2, TNF, IL9, IL12B, IFNGR1
29
Show member pathways
8.2TNF, CXCL10, IL12B, IFNGR1, IL12A, ICAM1
30
Show member pathways
8.1ANGPT2, IL12B, IL9, CXCL11, CXCL10, TNF
31
Show member pathways
8.1IL12A, IL9, IL12B, ANGPT2, TNF, CXCL10
32
Show member pathways
8.1IL9, TNF, IL12B, CXCL11, IL12A, CXCL10
33
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.1TNF, CXCL11, CXCL10, IFNGR1, IL12A, IL12B
34
Show member pathways
8.0IL12A, TNF, ICAM1, IL12B, IFNGR1, KIR2DL3
35
Show member pathways
7.6IL9, IL12B, IL12A, IFNGR1, ANGPT2, CXCL10

Compounds for genes affiliated with Cerebral Malaria

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 3BitterDB, 24HMDB
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Compounds related to Cerebral Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1cdp5714510.4TNF, ICAM1
2interferon gamma4510.4ICAM1, TNF
311-deoxy-pge14510.3ICAM1, CD36
4n-tosyl-l-phenylalanine chloromethyl ketone4510.3ICAM1, TNF
5budesonide45 51 1112.3TNF, CD36, ICAM1
6ulinastatin4510.2TNF, ICAM1
7methacholine45 51 1112.2ICAM1, AHSP, IL9
8efalizumab45 1111.2TNF, ICAM1, FCGR3B
9natalizumab45 1111.2TNF, FCGR3B, ICAM1
10alefacept45 1111.1FCGR3B, TNF
11n-formylmethionyl-leucylphenylalanine4510.1TNF, ICAM1, FCGR3B
12mycophenolate mofetil45 51 1112.1CD36, IL12A, TNF
13groalpha4510.0CXCL10, ICAM1, TNF
14sulfasalazine29 45 51 1112.9TNF, IL12B, ICAM1
15neopterin459.9TNF, ICAM1, CXCL10
16infliximab45 51 1111.9TNF, CXCL10, ANGPT2
17pentoxifylline45 1110.9ICAM1, TNF, IL12B
18troglitazone45 29 61 1112.8ICAM1, CD36, TNF
19fibrinogen459.8TNF, AHSP, ICAM1, ANGPT2
20ccl345 2910.8TNF, CXCL10, CXCL11, ICAM1
21chloroquine45 3 51 29 1113.8TNF, TCN2, CXCL10
22herbimycin a45 6110.7ICAM1, CD36, TNF
23leukotriene b445 61 2411.7TNF, CXCL10, FCGR3B
24hydrocortisone45 3 61 1112.7CD36, TNF, CXCL10
25polyinosinic-polycytidylic acid459.7IL12B, CXCL10, TNF
26poly(i-c)459.7IL12B, CXCL10, TNF
27il 10459.7CXCL10, TNF, IL12B
28matrigel459.7ICAM1, ANGPT2, CD36, CXCL10
29sb 20358045 6110.6TNF, ICAM1, IL12B, CD36
30ccl445 2910.6IL12B, CXCL11, CXCL10
31cyclosporin a45 29 6111.6ICAM1, ANGPT2, TNF, CXCL11
32tarc459.6TNF, ICAM1, IL9, CXCL10, CXCL11
33h2o2459.6CD36, TNF, FCGR3B, ANGPT2, ICAM1
34histamine45 29 2411.6AHSP, CXCL10, TNF, ICAM1, IL9
35ly294002459.5TNF, IL12B, CD36, ANGPT2, ICAM1
36vegf459.4CXCL10, ICAM1, CD36, ANGPT2, TNF
37thymidine45 2410.3IL9, CXCL10, ANGPT2, TNF
38endotoxin459.3TNF, ICAM1, CXCL10, AHSP, IL12B
39genistein45 29 61 3 24 1114.3FCGR3B, TNF, ICAM1, CXCL10, CD36, IL9
40dexamethasone45 51 29 1112.3CXCL10, CD36, ICAM1, ANGPT2, CXCL11, TNF
41retinoic acid45 2410.3IL9, ICAM1, ANGPT2, CD36, CXCL10, TNF
42rantes459.0TNF, IL9, IL12B, ICAM1, CXCL11, CXCL10
43cycloheximide459.0TCN2, CD36, IL12B, ICAM1, CXCL10, TNF
44phosphatidylinositol458.9ICAM1, ANGPT2, CXCL10, IL12B, FCGR3B
45pge2458.8CD36, TNF, CXCL10, AHSP, IL12B, ANGPT2
46nitric oxide45 24 1110.8IL9, ICAM1, ANGPT2, CXCL10, TNF, AHSP
47oxygen45 249.7TNF, AHSP, ANGPT2, ICAM1, IFNGR1
48lipid458.3AHSP, FCGR3B, GYPA, TNF, CXCL10, IL12B
49calcium45 51 24 1110.9CXCL10, ANGPT2, CXCL11, CD36, GYPA, FCGR3B
50tyrosine457.3ICAM1, KIR2DL3, IL9, IFNGR1, ANGPT2, CXCL10

GO Terms for genes affiliated with Cerebral Malaria

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16Gene Ontology
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Cellular components related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058339.7HBE1, AHSP
2interleukin-12 complexGO:0435149.6IL12B, IL12A
3external side of plasma membraneGO:0098978.9TNF, GYPA, CXCL10, ICAM1, CD36
4extracellular regionGO:0055768.6FCGR3B, TCN2, CXCL10, CXCL11, ANGPT2, TNF
5integral component of plasma membraneGO:0058878.0TNF, GYPB, GYPA, ICAM1, IFNGR1, KIR2DL3
6extracellular spaceGO:0056157.8IL9, TNF, TCN2, CXCL10, CXCL11, ANGPT2
7plasma membraneGO:0058867.2TNF, FCGR3B, GYPB, GYPA, ANGPT2, ICAM1

Biological processes related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:03081610.1CXCL11, CXCL10
2T cell chemotaxisGO:01081810.1CXCL10, CXCL11
3positive regulation of nitric oxide biosynthetic processGO:04542910.1ICAM1, TNF
4defense response to Gram-positive bacteriumGO:05083010.0CD36, IL12A, TNF
5positive regulation of cAMP-mediated signalingGO:04395010.0CXCL11, CXCL10
6positive regulation of osteoclast differentiationGO:0456729.9TNF, IL12B
7positive regulation of tyrosine phosphorylation of Stat4 proteinGO:0425209.9IL12A, IL12B
8positive regulation of NK T cell activationGO:0511359.9IL12B, IL12A
9positive regulation of lymphocyte proliferationGO:0506719.9IL12A, IL12B
10positive regulation of NF-kappaB import into nucleusGO:0423469.9TNF, IL12B
11positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:0028609.9IL12A, IL12B
12negative regulation of growth of symbiont in hostGO:0441309.9TNF, IL12B, CD36
13positive regulation of smooth muscle cell apoptotic processGO:0343939.9IL12A, IL12B
14positive regulation of natural killer cell activationGO:0328169.9IL12A, IL12B
15positive regulation of release of sequestered calcium ion into cytosolGO:0512819.9CXCL10, CXCL11
16negative regulation of interleukin-17 productionGO:0327009.9IL12B, IL12A
17cellular response to lipopolysaccharideGO:0712229.9CD36, IL12B, ICAM1
18response to UV-BGO:0102249.9IL12A, IL12B
19defense response to protozoanGO:0428329.8IL12B, IL12A
20positive regulation of interleukin-12 productionGO:0327359.8CD36, IL12B
21chemokine-mediated signaling pathwayGO:0700989.8CXCL10, CXCL11
22positive regulation of interferon-gamma productionGO:0327299.7IL12B, IL12A, TNF
23positive regulation of T cell mediated cytotoxicityGO:0019169.7IL12B, IL12A
24response to activityGO:0148239.7ANGPT2, TNF
25response to virusGO:0096159.6TNF, IFNGR1, IL12A
26inflammatory responseGO:0069549.6IL9, CXCL11, CXCL10, TNF
27negative regulation of smooth muscle cell proliferationGO:0486629.5IL12A, IL12B
28immune responseGO:0069558.8KIR2DL3, IL9, IL12A, CXCL11, CXCL10, FCGR3B

Molecular functions related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CXCR3 chemokine receptor bindingGO:0482489.7CXCL10, CXCL11
2growth factor activityGO:0080839.4IL9, IL12B, IL12A
3interleukin-12 receptor bindingGO:0051439.3IL12A, IL12B
4cytokine activityGO:0051259.1IL9, IL12B, IL12A, TNF
5virus receptor activityGO:0016188.9ICAM1, GYPA, HAVCR1

Products for genes affiliated with Cerebral Malaria

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  • Antibodies
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Sources for Cerebral Malaria

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet