CM
MCID: CRB021
MIFTS: 59

Cerebral Malaria (CM) malady

Summaries for Cerebral Malaria

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by plasmodium species.

MalaCards: Cerebral Malaria, also known as malaria, cerebral, is related to malaria and hepatocellular carcinoma. An important gene associated with Cerebral Malaria is ICAM1 (intercellular adhesion molecule 1), and among its related pathways are LDL Oxidation in Atherogenesis and African trypanosomiasis. The drug pentoxifylline and the compounds endotoxin and rantes have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and endothelial, and related mouse phenotypes are immune system and homeostasis/metabolism.

Description from OMIM:46 611162

Aliases & Classifications for Cerebral Malaria

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8Disease Ontology, 38NCBI Bookshelf, 46OMIM, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

cerebral malaria 8
malaria, cerebral 46 60
malarial encephalitis 8
malaria cerebral 44
cm 38


External Ids:

Disease Ontology8 DOID:14069
SNOMED-CT56 186799006, 53622003
MeSH34 D016779

Related Diseases for Cerebral Malaria

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1malaria32.0GYPB, CD36, CXCL9, IL12B, TCN2, TNF
2hepatocellular carcinoma30.6CXCL9, ANGPT2, HBE1
3adenocarcinoma30.3ANGPT2, KLF4, CXCL10
4encephalitis30.2CXCL10, CXCL9, IL12B
5meningitis30.2CXCL10
6peritonitis30.2TNF
7hepatitis30.1CCL11, HAVCR1, HBE1, CXCL10
8liver cirrhosis30.1HBE1
9obesity30.0TNF, CCL11
10ischemia30.0ANGPT2, AHSP, ICAM1
11systemic lupus erythematosus30.0TNF, CXCL10, IL12B, ICAM1
12pancreatitis29.9ICAM1
13breast cancer29.9KLF4, CXCL10, CXCL9, CCL11, ANGPT2
14hepatitis b29.7HBE1, CXCL10
15myocardial infarction29.7AHSP, ACE2, CCL11
16esophagitis29.7CCL11
17adenoma29.7ANGPT2, KLF4
18myeloma29.7ANGPT2, CD36, ICAM1
19melanoma29.7TNF, CXCL9, CD36, ANGPT2, CCL11, ICAM1
20hepatitis a29.7HBE1
21cerebritis11.4
22plasmodium malariae malaria10.9
23plasmodium falciparum malaria10.7
24congenital myasthenic syndrome10.4
25plasmodium vivax malaria10.4
26neuronitis10.3
27renal cell carcinoma10.3
28retinitis10.3
29chiari malformation10.3
30brain disease10.2
31papillary carcinoma10.2
32insulinoma10.2
33lung adenocarcinoma10.2
34papillary thyroid carcinoma10.2
35thyroiditis10.2
36chiari malformation type 210.2
37brain edema10.1
38protein-energy malnutrition10.1
39malaria, cerebral, reduced risk of10.1
40capillary malformation-arteriovenous malformation syndrome10.1
41congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.1
42myasthenic syndrome, fast-channel congenital10.1
43coloboma10.1
44angiomyolipoma10.1
45lung cancer10.1
46optic atrophy10.1
47ovarian disease10.1
48slow-channel congenital myasthenic syndrome10.1
49myasthenic syndrome, congenital, associated with episodic apnea10.1
50mixed malaria10.0

Graphical network of the top 20 diseases related to Cerebral Malaria:



Diseases related to cerebral malaria

Clinical Features for Cerebral Malaria

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46OMIM
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Clinical features from OMIM:

611162

Drugs & Therapeutics for Cerebral Malaria

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebral Malaria

Drug clinical trials:

Search ClinicalTrials for Cerebral Malaria

Search NIH Clinical Center for Cerebral Malaria

Search CenterWatch for Cerebral Malaria

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cerebral Malaria

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Anatomical Context for Cerebral Malaria

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32MalaCards
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MalaCards organs/tissues related to Cerebral Malaria:

32
Brain, T cells, Endothelial, Eye, Whole blood, Cortex, B cells, Monocytes, Nk cells, Testes, Liver, Kidney, Heart, Spleen, Temporal lobe

Animal Models for Cerebral Malaria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cerebral Malaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.5IL9, CCL11, ICAM1, TNF, HAVCR1, ANGPT2
2MP:000537610.4TNF, TNFAIP1, ICAM1, KLF4, ANGPT2, CD36
3MP:001076810.4ICAM1, TNF, ANGPT2, CD36, AHSP, CXCL10
4MP:000539710.3CCL11, ICAM1, TNF, HAVCR1, CD36, AHSP
5MP:000538110.2KLF4, ICAM1, TNF, ANGPT2, CD36, IL12B

Publications for Cerebral Malaria

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50PubMed
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Articles related to Cerebral Malaria:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria. (23890318)
2013
2
Transdermal glyceryl trinitrate as an effective adjunctive treatment with artemether for late-stage experimental cerebral malaria. (23979751)
2013
3
Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA. (23780878)
2013
4
Brain-derived neurotrophic factor and the course of experimental cerebral malaria. (23123703)
2013
5
Cerebral malaria. (23829902)
2013
6
CXCL10 Gene Promoter Polymorphism -1447A>G Correlates with Plasma CXCL10 Levels and is Associated with Male Susceptibility to Cerebral Malaria. (24349056)
2013
7
Improvement of the efficacy of dihydroartemisinin with atorvastatin in an experimental cerebral malaria murine model. (23988087)
2013
8
MRI findings in a cohort of brain injured survivors of pediatric cerebral malaria. (23339204)
2013
9
Age-related CD4(+)CD25(+)Foxp3(+) regulatory T-cell responses during Plasmodium berghei ANKA infection in mice susceptible or resistant to cerebral malaria. (23864739)
2013
10
Prevalence of raised intracranial pressure in cerebral malaria detected by optic nerve sheath ultrasound. (23033398)
2012
11
Neuroimmunological blood brain barrier opening in experimental cerebral malaria. (23133375)
2012
12
Human cerebral malaria and Plasmodium falciparum genotypes in Malawi. (22314206)
2012
13
Cerebral malaria: we have come a long way. (23021981)
2012
14
The novel ETA receptor antagonist HJP-272 prevents cerebral microvascular hemorrhage in cerebral malaria and synergistically improves survival in combination with an artemisinin derivative. (22820174)
2012
15
Plasmodium berghei ANKA: erythropoietin activates neural stem cells in an experimental cerebral malaria model. (21044627)
2011
16
CXCL4 and CXCL10 predict risk of fatal cerebral malaria. (21508508)
2011
17
Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria. (21905788)
2011
18
Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria. (21967768)
2011
19
Developmental outcomes in Malawian children with retinopathy-positive cerebral malaria. (21143354)
2011
20
Timing of enteral feeding in cerebral malaria in resource-poor settings: a randomized trial. (22110624)
2011
21
Persistent cognitive and motor deficits after successful antimalarial treatment in murine cerebral malaria. (20800692)
2010
22
Cerebral malaria: in praise of epistemes. (20363672)
2010
23
The effects of hypoxia on the ERG in paediatric cerebral malaria. (19557018)
2010
24
Simultaneous administration of vitamin A and DTP vaccine modulates the immune response in a murine cerebral malaria model. (20883315)
2010
25
Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review. (20454480)
2009
26
Advances in the management of cerebral malaria in adults. (19434799)
2009
27
Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria. (19000912)
2009
28
Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. (18347328)
2008
29
High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria. (18263734)
2008
30
Case series: MRI features in cerebral malaria. (19774162)
2008
31
Plasmodium vivax cerebral malaria. (17620697)
2007
32
A-5 year review of cerebral malaria in nigerian children. (17356594)
2007
33
Cutting edge: conventional dendritic cells are the critical APC required for the induction of experimental cerebral malaria. (17475826)
2007
34
Significant association between TNF-alpha (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand. (17493155)
2007
35
Epilepsy as a consequence of cerebral malaria in area in which malaria is endemic in Mali, West Africa. (16686652)
2006
36
A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. (16979941)
2006
37
Rehabilitation for cognitive impairments after cerebral malaria in African children: strategies and limitations. (16930255)
2006
38
Studies on the glycoprotein modification in erythrocyte membrane during experimental cerebral malaria. (16753147)
2006
39
Cerebral malaria: role of microparticles and platelets in alterations of the blood-brain barrier. (16600245)
2006
40
A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. (16414123)
2006
41
Changes in optic nerve head blood flow in children with cerebral malaria and acute papilloedema. (17043298)
2006
42
Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment. (14982832)
2004
43
Cyclooxygenase-2 in the pathogenesis of murine cerebral malaria. (14767831)
2004
44
Neuropeptide-containing cells in the cortex and striatum of mice with cerebral malaria. (15206748)
2003
45
Heme oxygenase-1 in lesions of human cerebral malaria. (11194943)
2001
46
Isolated cerebellar edema and obstructive hydrocephalus in a child with cerebral malaria. (11734774)
2001
47
Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar. (11929592)
2001
48
Cytokine levels during mild and cerebral falciparum malaria in children living in a mesoendemic area. (9270734)
1997
49
Neurobiology of cerebral malaria and African sleeping sickness. (9365801)
1997
50
IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. (8050178)
1994

Genetic Variations for Cerebral Malaria

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Expression for genes affiliated with Cerebral Malaria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Malaria

Search GEO for disease gene expression data for Cerebral Malaria.

Pathways for genes affiliated with Cerebral Malaria

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome
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Pathways related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5ICAM1, TNF, CD36
210.5ICAM1, TNF, IL12B, IL12A
3
Hide members
10.5KIR2DL3, TNF, ICAM1, CCL11
410.5CXCL10, TNF, ICAM1
510.5CXCL10, TNF, ICAM1
610.5GYPB
710.5TNF, IL12B, IL12A
810.5IL12A, IL12B, TNF
9
Hide members
10.5TNF, IL12B, IL12A
1010.5TNF, IL12B, IL12A
1110.5IL12A, IL12B, TNF
1210.5TNF, IL12B, IL12A, IL9
13
Hide members
10.5CCL11, ICAM1, TNF, IL12B, IL12A, IL9
14
Hide members
10.5ICAM1, TNF, CXCL10, IL12B, IL12A
1510.5CCL11, CXCL11, CXCL10
16
Hide members
10.5CXCL10, IL12B, IL12A
1710.5CXCL9, CXCL10, ICAM1
18
Hide members
10.4CCL11, TNF, ANGPT2, IL12B, IL12A, IL9
19
Development PDGF signaling via STATs and NF-kB
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10.4IL12B, CXCL9, ANGPT2, TNF
20
Hide members
10.4ANGPT2, CXCL11, CXCL10, IL12B, IL12A, IL9
21
Hide members
10.4CXCL9, CXCL10, CXCL11, CD36, ICAM1, CCL11
22
Hide members
10.4TNF, CXCL11, CXCL10, CXCL9, IL12B, IL12A
2310.4CXCL9, CXCL10, CXCL11, CCL11
2410.4CCL11, CXCL11, CXCL10, CXCL9
25
Hide members
10.4CCL11, CXCL11, CXCL10, CXCL9
26
Hide members
10.4CCL11, TNF, ANGPT2, CXCL11, CXCL10, CXCL9
27
Hide members
10.4CCL11, TNF, ANGPT2, CXCL11, CXCL10, CXCL9
28
Hide members
10.4IL9, IL12A, IL12B, CXCL9, CXCL10, CXCL11

Compounds for genes affiliated with Cerebral Malaria

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cerebral Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.9ICAM1, AHSP
2rantes4410.9IL12B, ICAM1, TNF, CXCL11, IL9, CCL11
3pge24410.9CCL11, AHSP
4budesonide44 49 1112.9ICAM1, CD36, CCL11, TNF
5tarc4410.9TNF, CCL11, CXCL11, CXCL10, CXCL9, IL9
6ccl344 2811.9CXCL9, CXCL10, CXCL11, CCL11, ICAM1, TNF
7groalpha4410.9CCL11, CXCL9, CXCL10, TNF, ICAM1
8methacholine44 1111.9AHSP, IL9, ICAM1, CCL11
9poly(i-c)4410.9TNF, IL12B, CXCL10, CCL11
10ly2940024410.9CCL11, ICAM1, TNF, ANGPT2, CD36, IL12B
11histamine44 28 2412.9TNF, AHSP, CXCL10, CXCL9, ICAM1, IL9
12genistein44 28 59 2 11 2415.9CCL11, ICAM1, TNF, IL9, CXCL10, CD36
13dexamethasone44 49 28 1113.9CCL11, CXCL9, CXCL11, ANGPT2
14ccl444 2811.9CXCL10, CCL11, CXCL11, IL12B, CXCL9
15il 104410.9TNF, CXCL9, IL12B, CXCL10
16sb 20358044 5911.9IL12B, CD36, ICAM1, CCL11, TNF
17troglitazone44 28 59 1113.9CCL11, ICAM1, TNF, CD36
18matrigel4410.9CXCL10, CCL11
19sulfasalazine44 28 49 1113.8IL12B, ICAM1, TNF
20nitric oxide44 11 2412.8ANGPT2, CXCL9, IL12B, IL9, ACE2, KLF4
21vegf4410.8CXCL10, CXCL9, CD36, ICAM1, CCL11, TNF
22cycloheximide4410.8TCN2, CXCL10
23herbimycin a44 5911.8CCL11, ICAM1, CD36, TNF
24thymidine44 2411.8IL9, CCL11, KLF4, TNF, CXCL10, ANGPT2
25retinoic acid44 2411.8ICAM1, IL9, TNF, CCL11, ANGPT2, CD36
26fluticasone propionate44 49 59 1113.8CCL11, TNF, CXCL10
27lysophosphatidylcholine44 2811.8ICAM1, CXCL9, CXCL11
28polyinosinic-polycytidylic acid4410.8TNF, CXCL10, IL12B
29tyrosine4410.8IL9, CCL11, KIR2DL3, CXCL9, CXCL10, ANGPT2
30ionomycin4410.8CXCL9, TNF, CCL11, IL9
31captopril44 28 49 59 1114.8ACE2, CD36, AHSP
32cyclosporin a44 28 5912.8TNF, ICAM1, ANGPT2, CCL11, CXCL11
33tacrolimus44 49 1112.8CXCL10, CD36, TNF, CCL11
34cdp5714410.8TNF, ICAM1
35infliximab44 49 1112.8CXCL10, ANGPT2, TNF
36peptidoglycan44 2811.7CCL11, IL12B, TNF
37n-formylmethionyl-leucylphenylalanine4410.7ICAM1, CCL11, TNF
38pentoxifylline44 1111.7IL12B, ICAM1, TNF
39phosphatidylinositol4410.7CCL11, ICAM1, IL12B, CXCL9, CXCL10, ANGPT2
40interferon gamma4410.7TNF, ICAM1
41neopterin4410.7TNF, CXCL10, ICAM1
42creatinine4410.7ANGPT2, CD36, TCN2, CXCL10, CXCL9
43allergens4410.6CXCL10, CCL11, IL9
4415-deoxy-delta-12,14-prostaglandin j24410.6CCL11, TNF, CD36
45anti-histamine4410.6CCL11, ICAM1
46oxygen44 2411.5ACE2, AHSP, ICAM1, ANGPT2, TNF, CCL11
47n-tosyl-l-phenylalanine chloromethyl ketone4410.5ICAM1, TNF
48sodium cromoglycate4410.5ICAM1, CCL11
4911-deoxy-pge14410.4CD36, ICAM1
50chloroquine44 2 49 28 1114.2TCN2, CXCL10, TNF

GO Terms for genes affiliated with Cerebral Malaria

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16Gene Ontology
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Cellular components related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:00583310.5HBE1, AHSP
2extracellular spaceGO:00561510.5ACE2, CCL11, ICAM1, TNF, ANGPT2, CXCL11
3external side of plasma membraneGO:00989710.5ICAM1, TNF, CD36, CXCL10, CXCL9
4interleukin-12 complexGO:04351410.4IL12A, IL12B
5extracellular regionGO:00557610.1CCL11, TNF, ANGPT2, CXCL11, CXCL10, CXCL9

Biological processes related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.8TNF, CD36, IL12B
2inflammatory responseGO:00695410.8CCL11, TNF, CXCL11, CXCL10, CXCL9, IL9
3negative regulation of smooth muscle cell proliferationGO:04866210.8IL12A, IL12B, KLF4
4positive regulation of interferon-gamma productionGO:03272910.8IL12A, IL12B, TNF
5response to virusGO:00961510.8CCL11, TNF, IL12A, ACE2
6immune responseGO:00695510.8KIR2DL3, CCL11, TNFAIP1, CXCL11, CXCL10, CXCL9
7defense response to Gram-positive bacteriumGO:05083010.8TNF, CD36, IL12A
8chemotaxisGO:00693510.8CCL11, CXCL11, CXCL10, CXCL9
9receptor biosynthetic processGO:03280010.7TNF, ACE2
10positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.7IL12A, IL12B
11virion attachment, binding of host cell surface receptorGO:04681310.7ACE2, ICAM1
12positive regulation of NK T cell activationGO:05113510.7IL12B, IL12A
13positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.7IL12A, IL12B
14positive regulation of lymphocyte proliferationGO:05067110.7IL12A, IL12B
15positive regulation of smooth muscle cell apoptotic processGO:03439310.6IL12B, IL12A
16positive regulation of natural killer cell activationGO:03281610.6IL12B, IL12A
17cellular response to lipopolysaccharideGO:07122210.6IL12B, CD36, ICAM1
18negative regulation of interleukin-17 productionGO:03270010.5IL12A, IL12B
19positive regulation of osteoclast differentiationGO:04567210.5IL12B, TNF
20response to UV-BGO:01022410.5IL12B, IL12A
21positive regulation of leukocyte chemotaxisGO:00269010.4CXCL10, CXCL11
22defense response to protozoanGO:04283210.2IL12A, IL12B

Molecular functions related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 receptor bindingGO:00514310.5IL12A, IL12B
2chemokine activityGO:00800910.4CXCL9, CXCL10, CXCL11, CCL11
3cytokine activityGO:00512510.4TNF, CXCL9, IL12B, IL12A, IL9
4virus receptor activityGO:00161810.2ACE2, HAVCR1, ICAM1

Products for genes affiliated with Cerebral Malaria

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  • Antibodies
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Sources for Cerebral Malaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet