CM
MCID: CRB021
MIFTS: 60

Cerebral Malaria (CM) malady

Infectious diseases category
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Summaries for Cerebral Malaria

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Disease Ontology:8 A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by plasmodium species.

MalaCards based summary: Cerebral Malaria, also known as malaria, cerebral, is related to malaria and systemic lupus erythematosus. An important gene associated with Cerebral Malaria is ICAM1 (intercellular adhesion molecule 1), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drug pentoxifylline and the compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and endothelial, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Description from OMIM:46 611162

Aliases & Classifications for Cerebral Malaria

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Cerebral Malaria, Aliases & Descriptions:

Name: Cerebral Malaria 8
Malaria, Cerebral 46 62
Malarial Encephalitis 8
 
Malaria Cerebral 44
Cm 38


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:14069
SNOMED-CT57 186799006, 53622003
MeSH34 D016779

Related Diseases for Cerebral Malaria

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Diseases related to Cerebral Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1malaria30.9ICAM1, TNF, TCN2, GYPA, IFNGR1, IL12B
2systemic lupus erythematosus30.8FCGR3B
3hepatitis30.1CXCL10, HBE1, HAVCR1
4ischemia30.0AHSP, ANGPT2, ICAM1, SERPINI1
5liver cirrhosis30.0CXCL10, SERPINI1, ANGPT2
6melanoma29.2ANGPT2, CD36, ICAM1, TNF, CXCL10
7cerebritis11.4
8endotheliitis10.6
9hemoglobinuria10.5TCN2
10hepatocellular carcinoma10.5
11hepatitis a10.5HBE1
12rheumatoid vasculitis10.4ICAM1
13congenital myasthenic syndrome10.4
14leukostasis10.4ICAM1
15multicentric reticulohistiocytosis10.4HAVCR1
16neuronitis10.4
17mycobacterium avium complex disease10.4IFNGR1
18renal cell carcinoma10.4
19retinitis10.3
20chiari malformation10.3
21typhoid fever10.3IFNGR1
22asthma10.3IL12B, TNF
23allergic contact dermatitis10.3CXCL10, CXCL11, ICAM1
24plasmodium falciparum malaria10.3
25brain edema10.3
26proliferative diabetic retinopathy10.3CXCL10, ICAM1, ANGPT2
27adenocarcinoma10.3
28congenital myasthenic syndrome with episodic apnea10.3
29dermatitis10.3CXCL11, CXCL10, ICAM1
30insulinoma10.2
31thyroiditis10.2
32capillary malformation-arteriovenous malformation syndrome10.2
33chiari malformation type 210.2
34psoriatic arthritis10.2ANGPT2, TNF
35lichen planus10.2CXCL11, ICAM1
36septic shock10.2IL12B, TNF, ANGPT2
37atopy10.2IL9, HAVCR1, IL12B
38brain injury10.2
39encephalitis10.2
40meningitis10.2
41protein-energy malnutrition10.2
42malaria, cerebral, reduced risk of10.2
43alcoholic hepatitis10.2TNF, ICAM1
44vasculitis10.2TNF, ICAM1, FCGR3B
45chronic obstructive pulmonary disease10.2AHSP, TNF, IL9, CXCL10
46immunodeficiency with hyper igm type 210.2FCGR3B, ANGPT2, CXCL10, IL12B
47cervicitis10.2
48peritonitis10.2
49congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.2
50renal cell carcinoma 410.2

Graphical network of the top 20 diseases related to Cerebral Malaria:



Diseases related to cerebral malaria

Symptoms for Cerebral Malaria

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Clinical features from OMIM:

611162

Drugs & Therapeutics for Cerebral Malaria

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Drug clinical trials:

Search ClinicalTrials for Cerebral Malaria

Search NIH Clinical Center for Cerebral Malaria

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cerebral Malaria

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Anatomical Context for Cerebral Malaria

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MalaCards organs/tissues related to Cerebral Malaria:

32
Brain, T cells, Endothelial, Eye, Whole blood, Cortex, Monocytes, B cells, Spleen, Heart, Kidney, Liver, Testes, Nk cells, Temporal lobe, Neutrophil

Animal Models for Cerebral Malaria or affiliated genes

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MGI Mouse Phenotypes related to Cerebral Malaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5ICAM1, IFNGR1, IL12A, IL12B, TNF
2MP:00053818.4IL12B, IL9, CD36, TNF, ANGPT2, ICAM1
3MP:00107687.7IL12A, IL12B, CXCL10, ICAM1, ANGPT2, TNF
4MP:00053977.3CD36, AHSP, TNF, CXCL10, ICAM1, IFNGR1
5MP:00053877.1ANGPT2, AHSP, TNF, CXCL10, ICAM1, IFNGR1
6MP:00053766.8CD36, IL9, IL12B, IFNGR1, IL12A, ICAM1

Publications for Cerebral Malaria

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Articles related to Cerebral Malaria:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Histidine-rich protein 2 plasma levels predict progression to cerebral malaria in Malawian children with Plasmodium falciparum infection. (23630364)
2013
2
Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria. (23890318)
2013
3
Dose responses of proveblue methylene blue in an experimental murine cerebral malaria model. (23669389)
2013
4
Clinical and laboratory predictors of outcome in cerebral malaria in suburban Nigeria. (23949295)
2013
5
Neurocognitive sequelae of cerebral malaria in adults: a pilot study in Benguela Central Hospital, Angola. (23836023)
2013
6
High Plasma Levels of Soluble Intercellular Adhesion Molecule (ICAM)-1 Are Associated with Cerebral Malaria. (24386348)
2013
7
Association of TNF level with production of circulating cellular microparticles during clinical manifestation of human cerebral malaria. (23459075)
2013
8
IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice. (23585679)
2013
9
Neuroleptic malignant syndrome masked by cerebral malaria. (23704432)
2013
10
Neurological sequelae in survivors of cerebral malaria. (24198884)
2013
11
IFN-I^-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. (22723523)
2012
12
Prevalence of raised intracranial pressure in cerebral malaria detected by optic nerve sheath ultrasound. (23033398)
2012
13
Plasmodium berghei ANKA: erythropoietin activates neural stem cells in an experimental cerebral malaria model. (21044627)
2011
14
CD8+ T cells and IFN-I^ mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria. (21494565)
2011
15
Nogo-A expression in the brain of mice with cerebral malaria. (21980529)
2011
16
CXCL4 and CXCL10 predict risk of fatal cerebral malaria. (21508508)
2011
17
Cutting edge: the membrane attack complex of complement is required for the development of murine experimental cerebral malaria. (21572031)
2011
18
The neuropathology of fatal cerebral malaria in malawian children. (21514429)
2011
19
In the eye of experimental cerebral malaria. (21741941)
2011
20
The murine cerebral malaria phenomenon. (19932638)
2010
21
Severe neurological sequelae and behaviour problems after cerebral malaria in Ugandan children. (20398391)
2010
22
Rethinking cerebral malaria pathology. (20613511)
2010
23
Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria. (20454664)
2010
24
Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. (20110412)
2010
25
Fluorescein angiography findings strengthen the theoretical basis for trialling neuroprotective agents in cerebral malaria. (19635680)
2009
26
Severe retinal whitening in an adult with cerebral malaria. (19478242)
2009
27
Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria. (20003529)
2009
28
Retinal pathology of pediatric cerebral malaria in Malawi. (19177166)
2009
29
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
30
Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (18294362)
2008
31
Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. (18347328)
2008
32
Evaluation of alternative diagnostic techniques for diagnosis of cerebral malaria in a tertiary referral hospital in Bangladesh. (18626455)
2008
33
Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. (18644885)
2008
34
Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. (17997848)
2007
35
Glial activation and matrix metalloproteinase release in cerebral malaria. (17454443)
2007
36
Plasmodium vivax cerebral malaria. (17620697)
2007
37
Cerebral malaria is associated with IgG2 and IgG4 antibody responses to recombinant Plasmodium falciparum RIFIN antigen. (16679041)
2006
38
Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. (16500656)
2006
39
Epilepsy as a consequence of cerebral malaria in area in which malaria is endemic in Mali, West Africa. (16686652)
2006
40
Experimental models of cerebral malaria. (16265904)
2005
41
Fulminant cerebral malaria in a Swiss patient. (15750758)
2005
42
Parasite diversity in adult patients with cerebral malaria: a hospital-based, case-control study. (15642966)
2004
43
Differentiating the pathologies of cerebral malaria by postmortem parasite counts. (14745442)
2004
44
Commonly recognised Plasmodium falciparum parasites cause cerebral malaria. (13680376)
2003
45
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. (12421634)
2002
46
Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais. (11719109)
2001
47
Removal of plasma polymorphonuclear leukocyte elastase and TNFalpha in a child with cerebral malaria by means of PD: a case report. (10433165)
1999
48
Inducible nitric oxide synthase polymorphism and fatal cerebral malaria. (9777841)
1998
49
Inhibition of tumour necrosis factor (TNF) production by antimalarial drugs used in cerebral malaria. (7778153)
1995
50
TNF in cerebral malaria. (8483997)
1993

Variations for Cerebral Malaria

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Clinvar genetic disease variations for Cerebral Malaria:

6
id Gene Name Type Significance SNP ID Assembly Location
1NM_013324.5(CISH): c.-524T> Asingle nucleotide variantrisk factorrs414171GRCh37Chr 3, 50649499: 50649499

Expression for genes affiliated with Cerebral Malaria

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Expression patterns in normal tissues for genes affiliated with Cerebral Malaria

Search GEO for disease gene expression data for Cerebral Malaria.

Pathways for genes affiliated with Cerebral Malaria

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Pathways related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TNF, ICAM1
2
Show member pathways
10.0TNF, IL12A
39.9ICAM1, TNF, CD36
4
Show member pathways
9.9TNF, IL12B
59.9TNF, IL12B
69.7IL12A, IL12B
79.7TNF, ICAM1, CXCL10
89.7CXCL10, TNF, ICAM1
99.6TNF, CD36, GYPA
10
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.6TNF, IL12B, ANGPT2
119.6TNF, IL12B, IL12A
129.6TNF, IL12A, IL12B
139.6IL12B, IL12A, TNF
149.6TNF, IL12A, IL12B
159.4FCGR3B, IFNGR1, TNF
169.4TNF, IL12B, ICAM1, IL12A
179.3IL12A, IL12B, IL9, TNF
189.3IFNGR1, ICAM1, CXCL10
19
Show member pathways
9.2CXCL10, IL12B, TNF, IL12A
20
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1CXCL11, IFNGR1, CXCL10, TNF
21
Show member pathways
IL27-mediated signaling events37
8.9IL12A, IL12B, IFNGR1, TNF
22
Show member pathways
Type III interferon signaling37
8.9IL9, IFNGR1, IL12A, IL12B
23
Show member pathways
Immune response CD16 signaling in NK cells60
8.9TNF, ICAM1, KIR2DL3, IFNGR1, FCGR3B
248.8CD36, IL12A, ICAM1, GYPA, GYPB, TNF
258.7IL12B, IL12A, FCGR3B, IFNGR1, TNF
26
Show member pathways
8.7FCGR3B, TNF, IFNGR1, IL12A, IL12B
27
Show member pathways
8.5ANGPT2, IL12A, IL12B, IL9, CXCL11, CXCL10
28
Show member pathways
8.5IL12B, IL12A, TNF, CXCL10, CXCL11, ANGPT2
29
Show member pathways
8.5CXCL10, TNF, CXCL11, ANGPT2, IL12A, IL12B
30
Show member pathways
8.5TNF, ANGPT2, IFNGR1, IL12A, IL12B, IL9
31
Show member pathways
8.4CXCL10, TNF, IL12B, IFNGR1, ICAM1, IL12A
32
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.3CXCL10, IL12B, IL12A, IFNGR1, CXCL11, TNF
33
Show member pathways
8.2IL12B, IL9, KIR2DL3, IL12A, IFNGR1, ICAM1
34
Show member pathways
7.9IL12A, IL12B, IL9, ANGPT2, CXCL11, CXCL10

Compounds for genes affiliated with Cerebral Malaria

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Compounds related to Cerebral Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1cdp5714410.5TNF, ICAM1
2interferon gamma4410.4TNF, ICAM1
311-deoxy-pge14410.4CD36, ICAM1
4n-tosyl-l-phenylalanine chloromethyl ketone4410.4ICAM1, TNF
5budesonide44 50 1112.3ICAM1, CD36, TNF
6efalizumab44 1111.3TNF, ICAM1, FCGR3B
7natalizumab44 1111.3TNF, FCGR3B, ICAM1
8methacholine44 50 1112.2IL9, ICAM1, AHSP
9ulinastatin4410.2TNF, ICAM1
10alefacept44 1111.2TNF, FCGR3B
11n-formylmethionyl-leucylphenylalanine4410.2ICAM1, FCGR3B, TNF
12mycophenolate mofetil44 50 1112.2IL12A, CD36, TNF
13groalpha4410.1ICAM1, TNF, CXCL10
14sulfasalazine28 44 50 1113.1TNF, ICAM1, IL12B
15neopterin4410.1CXCL10, TNF, ICAM1
16pentoxifylline44 1111.1ICAM1, IL12B, TNF
17infliximab44 50 1112.0ANGPT2, TNF, CXCL10
18ccl344 2810.9CXCL10, TNF, ICAM1, CXCL11
19troglitazone44 28 61 1112.9TNF, ICAM1, CD36
20fibrinogen449.9ANGPT2, AHSP, ICAM1, TNF
21chloroquine44 2 50 28 1113.9TNF, CXCL10, TCN2
22polyinosinic-polycytidylic acid449.9TNF, CXCL10, IL12B
23poly(i-c)449.9IL12B, CXCL10, TNF
24il 10449.9CXCL10, IL12B, TNF
25leukotriene b444 61 2411.9CXCL10, FCGR3B, TNF
26ccl444 2810.8IL12B, CXCL10, CXCL11
27matrigel449.8ICAM1, ANGPT2, CD36, CXCL10
28sb 20358044 6110.8IL12B, TNF, CD36, ICAM1
29hydrocortisone44 2 61 1112.8TNF, CXCL10, CD36
30tarc449.7TNF, CXCL10, CXCL11, ICAM1, IL9
31histamine44 28 2411.7AHSP, TNF, CXCL10, ICAM1, IL9
32h2o2449.7ICAM1, TNF, FCGR3B, ANGPT2, CD36
33ly294002449.7ANGPT2, IL12B, ICAM1, TNF, CD36
34herbimycin a44 6110.6TNF, ICAM1, CD36
35endotoxin449.6AHSP, TNF, CXCL10, ICAM1, IL12B
36cyclosporin a44 28 6111.5TNF, CXCL11, ICAM1, ANGPT2
37genistein44 28 61 2 24 1114.5CXCL10, TNF, FCGR3B, CD36, IL9, ICAM1
38dexamethasone44 50 28 1112.5CXCL11, TNF, ANGPT2, CD36, CXCL10, ICAM1
39vegf449.5ICAM1, ANGPT2, CXCL10, TNF, CD36
40thymidine44 2410.5IL9, TNF, ANGPT2, CXCL10
41retinoic acid44 2410.4ANGPT2, CXCL10, IL9, CD36, TNF, ICAM1
42rantes449.3TNF, CXCL10, IL12B, ICAM1, IL9, CXCL11
43cycloheximide449.3ICAM1, CXCL10, TCN2, IL12B, CD36, TNF
44serine449.2SERPINI1, GYPB, FCGR3B, ANGPT2, TNF, IL9
45phosphatidylinositol449.1FCGR3B, ICAM1, ANGPT2, CXCL10, IL12B
46pge2449.1AHSP, CXCL10, ANGPT2, ICAM1, IL12B, TNF
47nitric oxide44 24 1111.1AHSP, TNF, CXCL10, ANGPT2, ICAM1, IL12B
48lipid448.7CXCL10, IL12B, FCGR3B, TNF, AHSP, GYPA
49calcium44 50 24 1111.3GYPA, CXCL10, CXCL11, SERPINI1, CD36, FCGR3B
50tyrosine447.8HAVCR1, IFNGR1, FCGR3B, KIR2DL3, CXCL10, IL9

GO Terms for genes affiliated with Cerebral Malaria

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Cellular components related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058339.9AHSP, HBE1
2interleukin-12 complexGO:0435149.7IL12B, IL12A
3external side of plasma membraneGO:0098979.2TNF, GYPA, CXCL10, ICAM1, CD36
4extracellular regionGO:0055768.9FCGR3B, TCN2, CXCL10, CXCL11, ANGPT2, TNF
5integral component of plasma membraneGO:0058878.3TNF, GYPB, GYPA, ICAM1, IFNGR1, KIR2DL3
6extracellular spaceGO:0056158.0IL9, TNF, SERPINI1, TCN2, CXCL10, CXCL11
7plasma membraneGO:0058867.4TNF, FCGR3B, GYPB, GYPA, ANGPT2, ICAM1

Biological processes related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:03081610.2CXCL11, CXCL10
2T cell chemotaxisGO:01081810.2CXCL10, CXCL11
3defense response to Gram-positive bacteriumGO:05083010.1CD36, IL12A, TNF
4positive regulation of cAMP-mediated signalingGO:04395010.1CXCL11, CXCL10
5positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.1IL12A, IL12B
6positive regulation of NK T cell activationGO:05113510.1IL12B, IL12A
7positive regulation of lymphocyte proliferationGO:05067110.1IL12A, IL12B
8positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.1IL12A, IL12B
9negative regulation of growth of symbiont in hostGO:04413010.1TNF, IL12B, CD36
10positive regulation of natural killer cell activationGO:03281610.1IL12B, IL12A
11positive regulation of smooth muscle cell apoptotic processGO:03439310.0IL12B, IL12A
12positive regulation of NF-kappaB import into nucleusGO:04234610.0IL12B, TNF
13negative regulation of interleukin-17 productionGO:03270010.0IL12B, IL12A
14response to UV-BGO:01022410.0IL12B, IL12A
15positive regulation of osteoclast differentiationGO:04567210.0IL12B, TNF
16cellular response to lipopolysaccharideGO:07122210.0ICAM1, IL12B, CD36
17defense response to protozoanGO:0428329.9IL12B, IL12A
18positive regulation of interferon-gamma productionGO:0327299.9IL12B, IL12A, TNF
19positive regulation of release of sequestered calcium ion into cytosolGO:0512819.9CXCL11, CXCL10
20chemokine-mediated signaling pathwayGO:0700989.9CXCL11, CXCL10
21positive regulation of T cell mediated cytotoxicityGO:0019169.8IL12A, IL12B
22positive regulation of interleukin-12 productionGO:0327359.8CD36, IL12B
23inflammatory responseGO:0069549.7TNF, CXCL10, CXCL11, IL9
24response to virusGO:0096159.6IL12A, IFNGR1, TNF
25negative regulation of smooth muscle cell proliferationGO:0486629.4IL12B, IL12A
26cell migrationGO:0164779.1TNFAIP1, IL12A, IL12B
27immune responseGO:0069558.3KIR2DL3, IL9, IL12A, CXCL11, CXCL10, FCGR3B

Molecular functions related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CXCR3 chemokine receptor bindingGO:0482489.8CXCL11, CXCL10
2growth factor activityGO:0080839.5IL9, IL12B, IL12A
3interleukin-12 receptor bindingGO:0051439.4IL12A, IL12B
4virus receptor activityGO:0016189.4ICAM1, GYPA, HAVCR1
5cytokine activityGO:0051259.3IL9, IL12B, IL12A, TNF

Products for genes affiliated with Cerebral Malaria

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Sources for Cerebral Malaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet