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CM
MCID: CRB021
MIFTS: 59

Cerebral Malaria (CM) malady
1 drug, 103 genes, 15 tissues, 247 related diseases, clinical trials.

Summaries for Cerebral Malaria

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by plasmodium species.

MalaCards: Cerebral Malaria, also known as malaria, cerebral, is related to malaria and hepatocellular carcinoma. An important gene associated with Cerebral Malaria is ICAM1 (intercellular adhesion molecule 1), and among its related pathways are LDL Oxidation in Atherogenesis and African trypanosomiasis. The drug pentoxifylline and the compounds endotoxin and rantes have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and endothelial, and related mouse phenotypes are immune system and homeostasis/metabolism.

Description from OMIM:46 611162

Aliases & Classifications for Cerebral Malaria

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8Disease Ontology, 46OMIM, 44Novoseek, 38NCBI Bookshelf, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

cerebral malaria 8
malaria, cerebral 46 60
malarial encephalitis 8
malaria cerebral 44
cm 38


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Disease Ontology8 DOID:14069
SNOMED-CT56 186799006, 53622003
MeSH34 D016779

Related Diseases for Cerebral Malaria

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1malaria32.0GYPB, CD36, CXCL9, IL12B, TCN2, TNF
2hepatocellular carcinoma30.6CXCL9, ANGPT2, HBE1
3adenocarcinoma30.3ANGPT2, KLF4, CXCL10
4encephalitis30.2CXCL10, CXCL9, IL12B
5meningitis30.2CXCL10
6peritonitis30.2TNF
7hepatitis30.1CCL11, HAVCR1, HBE1, CXCL10
8liver cirrhosis30.1HBE1
9obesity30.0TNF, CCL11
10ischemia30.0ANGPT2, AHSP, ICAM1
11systemic lupus erythematosus30.0TNF, CXCL10, IL12B, ICAM1
12pancreatitis29.9ICAM1
13breast cancer29.9KLF4, CXCL10, CXCL9, CCL11, ANGPT2
14hepatitis b29.7HBE1, CXCL10
15myocardial infarction29.7AHSP, ACE2, CCL11
16esophagitis29.7CCL11
17adenoma29.7ANGPT2, KLF4
18myeloma29.7ANGPT2, CD36, ICAM1
19melanoma29.7TNF, CXCL9, CD36, ANGPT2, CCL11, ICAM1
20hepatitis a29.7HBE1
21cerebritis11.4
22plasmodium malariae malaria10.9
23plasmodium falciparum malaria10.7
24congenital myasthenic syndrome10.4
25plasmodium vivax malaria10.4
26neuronitis10.3
27renal cell carcinoma10.3
28retinitis10.3
29chiari malformation10.3
30brain disease10.2
31papillary carcinoma10.2
32insulinoma10.2
33lung adenocarcinoma10.2
34papillary thyroid carcinoma10.2
35thyroiditis10.2
36chiari malformation type 210.2
37brain edema10.1
38protein-energy malnutrition10.1
39malaria, cerebral, reduced risk of10.1
40capillary malformation-arteriovenous malformation syndrome10.1
41congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.1
42myasthenic syndrome, fast-channel congenital10.1
43coloboma10.1
44angiomyolipoma10.1
45lung cancer10.1
46optic atrophy10.1
47ovarian disease10.1
48slow-channel congenital myasthenic syndrome10.1
49myasthenic syndrome, congenital, associated with episodic apnea10.1
50mixed malaria10.0

Graphical network of the top 20 diseases related to Cerebral Malaria:



Diseases related to cerebral malaria

Clinical Features for Cerebral Malaria

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46OMIM
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Clinical features from OMIM:

611162

Drugs & Therapeutics for Cerebral Malaria

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebral Malaria

Drug clinical trials:

Search ClinicalTrials for Cerebral Malaria

Search NIH Clinical Center for Cerebral Malaria

Search CenterWatch for Cerebral Malaria

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cerebral Malaria

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Anatomical Context for Cerebral Malaria

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32MalaCards
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MalaCards organs/tissues related to Cerebral Malaria:

32
Brain, T cells, Endothelial, Eye, Cortex, Whole blood, B cells, Monocytes, Nk cells, Testes, Heart, Spleen, Kidney, Liver, Temporal lobe

Animal Models for Cerebral Malaria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cerebral Malaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
immune system phenotype
MP:000538710.5CXCL10, ICAM1, TNF, HAVCR1, CD36, AHSP
2
homeostasis/metabolism phenotype
MP:000537610.4KLF4, TNFAIP1, TNF, ANGPT2, CD36, IL12B
3
mortality/aging
MP:001076810.4ACE2, IL12A, IL12B, ICAM1, CXCL9, TNF
4
hematopoietic system phenotype
MP:000539710.3ICAM1, CCL11, TNF, HAVCR1, CD36, AHSP
5
digestive/alimentary phenotype
MP:000538110.2IL9, IL12B, CD36, ANGPT2, TNF, KLF4

Publications for Cerebral Malaria

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50PubMed
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Articles related to Cerebral Malaria:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice. (23585679)
2013
2
Modulation of cerebral malaria by curcumin as an adjunctive therapy. (23906771)
2013
3
Glucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malaria. (23991146)
2013
4
Susceptibility to lethal cerebral malaria is regulated by epistatic interaction between chromosome 4 (Berr6) and chromosome 1 (Berr7) loci in mice. (23594960)
2013
5
Plasmodium berghei ANKA Infection in ICR Mice as a Model of Cerebral Malaria. (23323093)
2012
6
Deletion of the complement phagocytic receptors CR3 and CR4 does not alter susceptibility to experimental cerebral malaria. (22882618)
2012
7
Cutting edge: Clec9A+ dendritic cells mediate the development of experimental cerebral malaria. (22732587)
2012
8
Nogo-A expression in the brain of mice with cerebral malaria. (21980529)
2011
9
Artemether and artesunate show the highest efficacies in rescuing mice with late-stage cerebral malaria and rapidly decrease leukocyte accumulation in the brain. (21220531)
2011
10
Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. (22110737)
2011
11
Schistosoma co-infection protects against brain pathology but does not prevent severe disease and death in a murine model of cerebral malaria. (20708623)
2011
12
Fatal cerebral malaria diagnosed after death in a French patient. (20508488)
2010
13
Natural regulatory T cells mediate the development of cerebral malaria by modifying the pro-inflammatory response. (20219695)
2010
14
The use of crude Plasmodium falciparum antigens for comparison of antibody responses in patients with mild malaria vs. cerebral malaria. (20876986)
2010
15
Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease. (20028608)
2010
16
Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19. (19865103)
2010
17
Cerebral malaria and epilepsy. (21056006)
2010
18
Safety of epoietin beta-quinine drug combination in children with cerebral malaria in Mali. (19630971)
2009
19
Malarial retinopathy in cerebral malaria. (19190205)
2009
20
Plasmodium vivax malaria presenting with severe thrombocytopenia, cerebral complications and hydrocephalus. (19390798)
2009
21
Causes of reduced immune complex clearance in cerebral malaria. (19149771)
2009
22
Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA. (19335550)
2009
23
Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages. (19815878)
2009
24
Rosiglitazone modulates the innate immune response to Plasmodium falciparum infection and improves outcome in experimental cerebral malaria. (19392627)
2009
25
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
26
Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. (18644885)
2008
27
Control of pathogenic CD8+ T cell migration to the brain by IFN-gamma during experimental cerebral malaria. (18665903)
2008
28
A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI. (18274670)
2008
29
Platelet factor 4 mediates inflammation in experimental cerebral malaria. (18692777)
2008
30
C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. (18426986)
2008
31
Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral malaria. (17785848)
2007
32
Behavioural and histopathological alterations in mice with cerebral malaria. (16599946)
2006
33
Characteristic abnormalities in cerebrospinal fluid biochemistry in children with cerebral malaria compared to viral encephalitis. (16764711)
2006
34
Conventional and experimental treatment of cerebral malaria. (16603167)
2006
35
Cerebral malaria in adult Sudanese patients. Clinical presentation and outcome. (22266507)
2006
36
Pathogenic T cells in cerebral malaria. (16600241)
2006
37
Neuronal apoptosis, metallothionein expression and proinflammatory responses during cerebral malaria in mice. (16624296)
2006
38
Coagulation profile in Nigerian children with cerebral malaria. (17066104)
2006
39
Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice. (16362897)
2006
40
Experimental models of cerebral malaria. (16265904)
2005
41
Plasmodium falciparum delayed cerebellar ataxia and late cerebral malaria. (15937892)
2005
42
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. (16098232)
2005
43
Striatal lesions: an underestimated complication of cerebral malaria? (15469459)
2004
44
A profound alteration of blood TCRB repertoire allows prediction of cerebral malaria. (15383590)
2004
45
Does intravenous mannitol improve outcome in cerebral malaria? (12818920)
2003
46
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. (12421634)
2002
47
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria. (9466588)
1998
48
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. (7935762)
1994
49
Immunopathological changes in human cerebral malaria. (8100753)
1993
50
Late administration of monoclonal antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria. (1679717)
1991

Genetic Variations for Cerebral Malaria

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Expression for genes affiliated with Cerebral Malaria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Malaria

Search GEO for disease gene expression data for Cerebral Malaria.

Pathways for genes affiliated with Cerebral Malaria

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome
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Pathways related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
LDL Oxidation in Atherogenesis51
10.5TNF, CD36, ICAM1
2
African trypanosomiasis29
10.5IL12A, IL12B, TNF, ICAM1
3
Immune response Fc epsilon RI pathway12
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10.5KIR2DL3, ICAM1, TNF, CCL11
4
TNF signaling pathway29
10.5CXCL10, TNF, ICAM1
5
Spinal Cord Injury37
10.5ICAM1, TNF, CXCL10
6
Malaria29
10.5GYPB
7
Legionellosis29
10.5IL12B, TNF, IL12A
8
Pertussis29
10.5IL12B, TNF, IL12A
9
IL27-mediated signaling events37
Hide members
10.5IL12A, IL12B, TNF
10
Amoebiasis29
10.5TNF, IL12A, IL12B
11
MSP-RON Signaling51
10.5IL12A, IL12B, TNF
12
Cytokine Network51
10.5TNF, IL12B, IL12A, IL9
13
Allograft rejection29
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10.5ICAM1, IL12B, IL12A, IL9, TNF, CCL11
14
Influenza A29
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10.5CXCL10, IL12A, TNF, IL12B, ICAM1
15
Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response12
10.5CXCL10, CCL11, CXCL11
16
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways53
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10.5IL12B, IL12A, CXCL10
17
Type II interferon signaling (IFNG)37
10.5CXCL10, CXCL9, ICAM1
18
TGF-Beta Pathway51
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10.4IL9, ANGPT2, TNF, IL12B, IL12A, CCL11
19
Development PDGF signaling via STATs and NF-kB
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10.4ANGPT2, CXCL9, IL12B, TNF
20
Rho Family GTPases51
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10.4IL9, CXCL10, ANGPT2, CXCL11, IL12A, IL12B
21
Integrin Pathway51
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10.4CXCL10, CXCL11, CD36, ICAM1, CCL11, CXCL9
22
Toll-like receptor signaling pathway37
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10.4CXCL10, CXCL11, CXCL9, IL12B, IL12A, TNF
23
CXCR3-mediated signaling events37
10.4CXCL9, CXCL10, CCL11, CXCL11
24
Chemokine Signaling51
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10.4CXCL11, CXCL10, CCL11, CXCL9
25
Chemokine receptors bind chemokines53
10.4CXCL10, CXCL11, CCL11, CXCL9
26
PEDF Induced Signaling51
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10.4CXCL9, TNF, CCL11, IL9, CXCL11, CXCL10
27
Akt Signaling51
Hide members
10.4IL9, IL12A, IL12B, CXCL9, CXCL11, CXCL10
28
PAK Pathway51
Hide members
10.4IL12B, CXCL9, CXCL11, IL12A, IL9, ANGPT2

Compounds for genes affiliated with Cerebral Malaria

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cerebral Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.9ICAM1, AHSP
2rantes4410.9IL12B, ICAM1, TNF, CXCL11, IL9, CCL11
3pge24410.9CCL11, AHSP
4budesonide44 49 1112.9ICAM1, CD36, CCL11, TNF
5tarc4410.9TNF, CCL11, CXCL11, CXCL10, CXCL9, IL9
6ccl344 2811.9CXCL9, CXCL10, CXCL11, CCL11, ICAM1, TNF
7groalpha4410.9CCL11, CXCL9, CXCL10, TNF, ICAM1
8methacholine44 1111.9AHSP, IL9, ICAM1, CCL11
9poly(i-c)4410.9TNF, IL12B, CXCL10, CCL11
10ly2940024410.9CCL11, ICAM1, TNF, ANGPT2, CD36, IL12B
11histamine44 28 2412.9TNF, AHSP, CXCL10, CXCL9, ICAM1, IL9
12genistein44 28 59 2 11 2415.9CCL11, ICAM1, TNF, IL9, CXCL10, CD36
13dexamethasone44 49 28 1113.9CCL11, CXCL9, CXCL11, ANGPT2
14ccl444 2811.9CXCL10, CCL11, CXCL11, IL12B, CXCL9
15il 104410.9TNF, CXCL9, IL12B, CXCL10
16sb 20358044 5911.9IL12B, CD36, ICAM1, CCL11, TNF
17troglitazone44 28 59 1113.9CCL11, ICAM1, TNF, CD36
18matrigel4410.9CXCL10, CCL11
19sulfasalazine44 28 49 1113.8IL12B, ICAM1, TNF
20nitric oxide44 11 2412.8ANGPT2, CXCL9, IL12B, IL9, ACE2, KLF4
21vegf4410.8CXCL10, CXCL9, CD36, ICAM1, CCL11, TNF
22cycloheximide4410.8TCN2, CXCL10
23herbimycin a44 5911.8CCL11, ICAM1, CD36, TNF
24thymidine44 2411.8IL9, CCL11, KLF4, TNF, CXCL10, ANGPT2
25retinoic acid44 2411.8ICAM1, IL9, TNF, CCL11, ANGPT2, CD36
26fluticasone propionate44 49 59 1113.8CCL11, TNF, CXCL10
27lysophosphatidylcholine44 2811.8ICAM1, CXCL9, CXCL11
28polyinosinic-polycytidylic acid4410.8TNF, CXCL10, IL12B
29tyrosine4410.8IL9, CCL11, KIR2DL3, CXCL9, CXCL10, ANGPT2
30ionomycin4410.8CXCL9, TNF, CCL11, IL9
31captopril44 28 49 59 1114.8ACE2, CD36, AHSP
32cyclosporin a44 28 5912.8TNF, ICAM1, ANGPT2, CCL11, CXCL11
33tacrolimus44 49 1112.8CXCL10, CD36, TNF, CCL11
34cdp5714410.8TNF, ICAM1
35infliximab44 49 1112.8CXCL10, ANGPT2, TNF
36peptidoglycan44 2811.7CCL11, IL12B, TNF
37n-formylmethionyl-leucylphenylalanine4410.7ICAM1, CCL11, TNF
38pentoxifylline44 1111.7IL12B, ICAM1, TNF
39phosphatidylinositol4410.7CCL11, ICAM1, IL12B, CXCL9, CXCL10, ANGPT2
40interferon gamma4410.7TNF, ICAM1
41neopterin4410.7TNF, CXCL10, ICAM1
42creatinine4410.7ANGPT2, CD36, TCN2, CXCL10, CXCL9
43allergens4410.6CXCL10, CCL11, IL9
4415-deoxy-delta-12,14-prostaglandin j24410.6CCL11, TNF, CD36
45anti-histamine4410.6CCL11, ICAM1
46oxygen44 2411.5ACE2, AHSP, ICAM1, ANGPT2, TNF, CCL11
47n-tosyl-l-phenylalanine chloromethyl ketone4410.5ICAM1, TNF
48sodium cromoglycate4410.5ICAM1, CCL11
4911-deoxy-pge14410.4CD36, ICAM1
50chloroquine44 2 49 28 1114.2TCN2, CXCL10, TNF

GO Terms for genes affiliated with Cerebral Malaria

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16Gene Ontology
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Cellular components related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:00583310.5AHSP, HBE1
2extracellular spaceGO:00561510.5CXCL10, ANGPT2, CXCL11, ICAM1, CXCL9, IL12B
3external side of plasma membraneGO:00989710.5CXCL9, CXCL10, CD36, TNF, ICAM1
4interleukin-12 complexGO:04351410.4IL12A, IL12B
5extracellular regionGO:00557610.1TCN2, CXCL9, CXCL10, CXCL11, ANGPT2, TNF

Biological processes related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.8TNF, IL12B, CD36
2inflammatory responseGO:00695410.8IL9, CCL11, TNF, CXCL11, CXCL10, CXCL9
3negative regulation of smooth muscle cell proliferationGO:04866210.8KLF4, IL12B, IL12A
4positive regulation of interferon-gamma productionGO:03272910.8TNF, IL12B, IL12A
5response to virusGO:00961510.8CCL11, ACE2, IL12A, TNF
6immune responseGO:00695510.8KIR2DL3, CCL11, TNFAIP1, CXCL11, CXCL10, CXCL9
7defense response to Gram-positive bacteriumGO:05083010.8TNF, CD36, IL12A
8chemotaxisGO:00693510.8CCL11, CXCL11, CXCL9, CXCL10
9receptor biosynthetic processGO:03280010.7ACE2, TNF
10positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.7IL12A, IL12B
11virion attachment, binding of host cell surface receptorGO:04681310.7ACE2, ICAM1
12positive regulation of NK T cell activationGO:05113510.7IL12A, IL12B
13positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.7IL12B, IL12A
14positive regulation of lymphocyte proliferationGO:05067110.7IL12B, IL12A
15positive regulation of smooth muscle cell apoptotic processGO:03439310.6IL12B, IL12A
16positive regulation of natural killer cell activationGO:03281610.6IL12B, IL12A
17cellular response to lipopolysaccharideGO:07122210.6IL12B, CD36, ICAM1
18negative regulation of interleukin-17 productionGO:03270010.5IL12B, IL12A
19positive regulation of osteoclast differentiationGO:04567210.5IL12B, TNF
20response to UV-BGO:01022410.5IL12B, IL12A
21positive regulation of leukocyte chemotaxisGO:00269010.4CXCL11, CXCL10
22defense response to protozoanGO:04283210.2IL12B, IL12A

Molecular functions related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 receptor bindingGO:00514310.5IL12A, IL12B
2chemokine activityGO:00800910.4CCL11, CXCL11, CXCL10, CXCL9
3cytokine activityGO:00512510.4TNF, CXCL9, IL12B, IL12A, IL9
4virus receptor activityGO:00161810.2ICAM1, HAVCR1, ACE2

Products for genes affiliated with Cerebral Malaria

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  • Antibodies
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  • Antibodies

Sources for Cerebral Malaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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