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CM
MCID: CRB021
MIFTS: 58

Cerebral Malaria (CM) malady
1 drug, 103 genes, 13 tissues, 231 related diseases, clinical trials.

Summaries for Cerebral Malaria

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8Disease Ontology, 47OMIM, 33MalaCards
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Disease Ontology:8 A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by plasmodium species.

MalaCards: Cerebral Malaria, also known as malaria, cerebral, is related to adenocarcinoma and insulin resistance. An important gene associated with Cerebral Malaria is ICAM1 (intercellular adhesion molecule 1), and among its related pathways are LDL Oxidation in Atherogenesis and African trypanosomiasis. The drug pentoxifylline and the compounds endotoxin and rantes have been mentioned in the context of this disorder. Affiliated tissues include whole blood, spleen and brain, and related mouse phenotypes are immune system and homeostasis/metabolism.

Description from OMIM:47 611162

Aliases & Classifications for Cerebral Malaria

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8Disease Ontology, 39NCBI Bookshelf, 47OMIM, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

cerebral malaria 8
malaria, cerebral 47 61
malarial encephalitis 8
malaria cerebral 45
cm 39


External Ids:

Disease Ontology8 DOID:14069
SNOMED-CT57 186799006, 53622003
MeSH35 D016779

Related Diseases for Cerebral Malaria

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.4CXCL10, ANGPT2, KLF4
2insulin resistance30.0TNF, CCL11
3systemic lupus erythematosus30.0ICAM1, TNF, CXCL10, IL12B
4hepatitis c30.0TNF, CXCL11, CXCL10, IL12B
5hepatitis a30.0HBE1
6adenoma29.8KLF4, ANGPT2
7plasmodium falciparum malaria10.7
8malaria, severe10.7
9congenital myasthenic syndrome10.4
10plasmodium vivax malaria10.4
11chiari malformations10.3
12brain disease10.3
13papillary carcinoma10.2
14insulinoma10.2
15chiari malformation type 210.2
16brain edema10.2
17brain injury10.2
18malaria, cerebral, reduced risk of10.2
19capillary malformation-arteriovenous malformation syndrome10.2
20congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.2
21myasthenic syndrome, fast-channel congenital10.2
22coloboma10.1
23angiomyolipoma10.1
24dominant optic atrophy10.1
25slow-channel congenital myasthenic syndrome10.1
26myasthenic syndrome, congenital, associated with episodic apnea10.1
27peritoneal carcinoma10.1
28primary peritoneal carcinoma10.1
29mixed malaria10.0
30sleeping sickness10.0
31temporal lobe epilepsy10.0
32central pontine myelinolysis10.0
33viral encephalitis10.0
34babesiosis10.0
35neuroleptic malignant syndrome10.0
36obstructive hydrocephalus10.0
37n syndrome10.0
38protein c deficiency10.0
39aphasia10.0
40bacterial meningitis10.0
41typhus10.0
42micro syndrome10.0
43autoimmune encephalitis10.0
44cerebral folate deficiency10.0
45meningococcal infection10.0
46protein r deficiency10.0
47splenomegaly10.0
48ataxia10.0
49cerebral hypoxia10.0
50hypoxia10.0

Graphical network of the top 20 diseases related to Cerebral Malaria:



Diseases related to cerebral malaria

Clinical Features for Cerebral Malaria

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47OMIM
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Clinical features from OMIM:

611162

Drugs & Therapeutics for Cerebral Malaria

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Cerebral Malaria

Drug clinical trials:

Search ClinicalTrials for Cerebral Malaria

Search NIH Clinical Center for Cerebral Malaria

Search CenterWatch for Cerebral Malaria

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cerebral Malaria

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Anatomical Context for Cerebral Malaria

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33MalaCards
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MalaCards organs/tissues related to Cerebral Malaria:

33
Whole blood, Spleen, Brain, Cortex, Heart, Kidney, Liver, Monocytes, Nk cells, T cells, B cells, Endothelial, Temporal lobe

Animal Models for Cerebral Malaria or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Cerebral Malaria:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
immune system phenotype
MP:000538710.5CXCL10, ICAM1, TNF, HAVCR1, CD36, AHSP
2
homeostasis/metabolism phenotype
MP:000537610.4KLF4, TNFAIP1, TNF, ANGPT2, CD36, IL12B
3
mortality/aging
MP:001076810.4ACE2, IL12A, IL12B, ICAM1, CXCL9, TNF
4
hematopoietic system phenotype
MP:000539710.3ICAM1, CCL11, TNF, HAVCR1, CD36, AHSP
5
digestive/alimentary phenotype
MP:000538110.2IL9, IL12B, CD36, ANGPT2, TNF, KLF4

Publications for Cerebral Malaria

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51PubMed
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Articles related to Cerebral Malaria:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Neuregulin-1 attenuates mortality associated with experimental cerebral malaria. (24433482)
2014
2
Dose responses of proveblue methylene blue in an experimental murine cerebral malaria model. (23669389)
2013
3
Association of TNF level with production of circulating cellular microparticles during clinical manifestation of human cerebral malaria. (23459075)
2013
4
A rare non-synonymous c.102C>G SNP in the IFNB1 gene might be a risk factor for cerebral malaria in Indian populations. (23333334)
2013
5
Role of IL-10-producing regulatory B cells in control of cerebral malaria in Plasmodium berghei infected mice. (23893352)
2013
6
Platelet-activating factor receptor is essential for the development of experimental cerebral malaria. (22079430)
2012
7
Acute brain MRI findings in 120 Malawian children with cerebral malaria: new insights into an ancient disease. (22517285)
2012
8
The Impact of HIV Coinfection on Cerebral Malaria Pathogenesis. (22545215)
2012
9
Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria. (23300448)
2012
10
Effect of vitamin A adjunct therapy for cerebral malaria in children admitted to Mulago hospital: a randomized controlled trial. (23056012)
2012
11
Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology. (21415018)
2011
12
The murine cerebral malaria phenomenon. (19932638)
2010
13
Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. (20110412)
2010
14
Microvesiculation and cell interactions at the brain-endothelial interface in cerebral malaria pathogenesis. (20117166)
2010
15
The platelet count in cerebral malaria, is it useful to the clinician? (20595476)
2010
16
Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study. (21056005)
2010
17
Modulation of cerebral malaria by fasudil and other immune-modifying compounds. (20093114)
2010
18
Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy. (20585569)
2010
19
Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study. (21209923)
2010
20
Murine cerebral malaria: the whole story. (20382078)
2010
21
IL-10 plays a crucial role for the protection of experimental cerebral malaria by co-infection with non-lethal malaria parasites. (19735663)
2010
22
Reversible splenial lesion syndrome in cerebral malaria. (20381148)
2010
23
Raised plasma insulin level and homeostasis model assessment (HOMA) score in cerebral malaria: evidence for insulin resistance and marker of virulence. (21140005)
2010
24
Fluorescein angiography findings strengthen the theoretical basis for trialling neuroprotective agents in cerebral malaria. (19635680)
2009
25
Neurological findings and outcome in adult cerebral malaria. (19637540)
2009
26
A preliminary examination of the construct validity of the KABC-II in Ugandan children with a history of cerebral malaria. (20589149)
2009
27
Genetic variation in neuronal nitric oxide synthase (nNOS) gene and susceptibility to cerebral malaria in Indian adults. (19540363)
2009
28
Concurrent gastro-intestinal nematode infection does not alter the development of experimental cerebral malaria. (18656411)
2008
29
Distinct pattern of class and subclass antibodies in immune complexes of children with cerebral malaria and severe malarial anaemia. (18466201)
2008
30
No evidence for implication of quinine treatment failure in development and fatality of cerebral malaria in Eastern Sudan. (18499404)
2008
31
NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria. (17442962)
2007
32
Pathological role of Toll-like receptor signaling in cerebral malaria. (17135446)
2007
33
Cerebral calpain in fatal falciparum malaria. (17359359)
2007
34
Cerebral malaria is associated with IgG2 and IgG4 antibody responses to recombinant Plasmodium falciparum RIFIN antigen. (16679041)
2006
35
Low levels of RANTES are associated with mortality in children with cerebral malaria. (16941352)
2006
36
Plasmodium falciparum: polymorphism in the MSP-1 gene in Indian isolates and predominance of certain alleles in cerebral malaria. (16300763)
2006
37
Fulminant cerebral malaria in a Swiss patient. (15750758)
2005
38
Species-specific inhibition of cerebral malaria in mice coinfected with Plasmodium spp. (16040990)
2005
39
Impaired systemic production of prostaglandin E2 in children with cerebral malaria. (15809915)
2005
40
Management of children with cerebral malaria in Lagos - a medical audit. (15627158)
2004
41
Commonly recognised Plasmodium falciparum parasites cause cerebral malaria. (13680376)
2003
42
Cerebral malaria and heme oxygenase-1]. (12704843)
2003
43
Angiogenic proteins in brains of patients who died with cerebral malaria. (14512169)
2003
44
Prevalence and case-control study of cerebral malaria in Limbe of the South-West Cameroon. (17298146)
2002
45
Evidence of blood-brain barrier dysfunction in human cerebral malaria. (10476050)
1999
46
Abnormally elevated serum transcobalamin II levels in patients with cerebral malaria. (7759977)
1994
47
A primate model for human cerebral malaria: Plasmodium coatneyi-infected rhesus monkeys. (1374220)
1992
48
Pentoxifylline prevents murine cerebral malaria. (1869848)
1991
49
Protein energy malnutrition and cerebral malaria. (1907328)
1991
50
The pathology of human cerebral malaria. (2202227)
1990

Genetic Variations for Cerebral Malaria

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Expression for genes affiliated with Cerebral Malaria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Malaria

Search GEO for disease gene expression data for Cerebral Malaria.

Pathways for genes affiliated with Cerebral Malaria

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52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 54Reactome
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Pathways related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
LDL Oxidation in Atherogenesis52
10.5ICAM1, TNF, CD36
2
African trypanosomiasis30
10.5ICAM1, TNF, IL12B, IL12A
3
Immune response Fc epsilon RI pathway12
Hide members
10.5KIR2DL3, TNF, ICAM1, CCL11
4
Spinal Cord Injury38
10.5CXCL10, TNF, ICAM1
5
TNF signaling pathway30
10.5CXCL10, TNF, ICAM1
6
Malaria30
10.5GYPB
7
Legionellosis30
10.5TNF, IL12B, IL12A
8
Pertussis30
10.5IL12A, IL12B, TNF
9
IL27-mediated signaling events38
Hide members
10.5TNF, IL12B, IL12A
10
Amoebiasis30
10.5TNF, IL12B, IL12A
11
MSP-RON Signaling52
10.5IL12A, IL12B, TNF
12
Cytokine Network52
10.5TNF, IL12B, IL12A, IL9
13
Allograft rejection30
Hide members
10.5CCL11, ICAM1, TNF, IL12B, IL12A, IL9
14
Influenza A30
Hide members
10.5ICAM1, TNF, CXCL10, IL12B, IL12A
15
Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response12
10.5CCL11, CXCL11, CXCL10
16
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways54
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10.5CXCL10, IL12B, IL12A
17
Type II interferon signaling (IFNG)38
10.5CXCL9, CXCL10, ICAM1
18
TGF-Beta Pathway52
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10.4CCL11, TNF, ANGPT2, IL12B, IL12A, IL9
19
Development PDGF signaling via STATs and NF-kB
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10.4IL12B, CXCL9, ANGPT2, TNF
20
Rho Family GTPases52
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10.4ANGPT2, CXCL11, CXCL10, IL12B, IL12A, IL9
21
Integrin Pathway52
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10.4CXCL9, CXCL10, CXCL11, CD36, ICAM1, CCL11
22
Toll-like receptor signaling pathway38
Hide members
10.4TNF, CXCL11, CXCL10, CXCL9, IL12B, IL12A
23
Chemokine receptors bind chemokines54
10.4CXCL9, CXCL10, CXCL11, CCL11
24
CXCR3-mediated signaling events38
10.4CCL11, CXCL11, CXCL10, CXCL9
25
Chemokine Signaling52
Hide members
10.4CCL11, CXCL11, CXCL10, CXCL9
26
PEDF Induced Signaling52
Hide members
10.4CCL11, TNF, ANGPT2, CXCL11, CXCL10, CXCL9
27
Akt Signaling52
Hide members
10.4CCL11, TNF, ANGPT2, CXCL11, CXCL10, CXCL9
28
PAK Pathway52
Hide members
10.4IL9, IL12A, IL12B, CXCL9, CXCL10, CXCL11

Compounds for genes affiliated with Cerebral Malaria

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45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Cerebral Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.9AHSP, ICAM1
2rantes4510.9CCL11, ICAM1, TNF, CXCL11, IL12B, IL9
3pge24510.9AHSP, CCL11
4budesonide45 50 1112.9CD36, TNF, ICAM1, CCL11
5tarc4510.9IL9, CCL11, ICAM1, TNF, CXCL11, CXCL10
6ccl345 2911.9CCL11, ICAM1, TNF, CXCL11, CXCL10, CXCL9
7groalpha4510.9CCL11, ICAM1, TNF, CXCL10, CXCL9
8methacholine45 1111.9CCL11, ICAM1, AHSP, IL9
9poly(i-c)4510.9CCL11, TNF, CXCL10, IL12B
10ly2940024510.9CCL11, ICAM1, TNF, ANGPT2, CD36, IL12B
11histamine45 29 2412.9CCL11, ICAM1, TNF, AHSP, CXCL10, CXCL9
12genistein45 29 60 2 11 2415.9CCL11, ICAM1, TNF, CD36, CXCL10, IL9
13dexamethasone45 50 29 1113.9CCL11, ANGPT2, CXCL11, CXCL9
14ccl445 2911.9CCL11, CXCL11, CXCL10, CXCL9, IL12B
15il 104510.9TNF, CXCL10, CXCL9, IL12B
16sb 20358045 6011.9CCL11, ICAM1, TNF, CD36, IL12B
17troglitazone45 29 60 1113.9CCL11, ICAM1, TNF, CD36
18matrigel4510.9CXCL10, CCL11
19sulfasalazine45 29 50 1113.8IL12B, TNF, ICAM1
20nitric oxide45 11 2412.8KLF4, CCL11, ICAM1, TNF, ANGPT2, AHSP
21vegf4510.8CCL11, ICAM1, TNF, ANGPT2, CD36, CXCL10
22cycloheximide4510.8TCN2, CXCL10
23herbimycin a45 6011.8CD36, TNF, ICAM1, CCL11
24thymidine45 2411.8KLF4, CCL11, TNF, ANGPT2, CXCL10, IL9
25retinoic acid45 2411.8CCL11, ICAM1, TNF, ANGPT2, CD36, CXCL10
26fluticasone propionate45 50 60 1113.8CCL11, TNF, CXCL10
27lysophosphatidylcholine45 2911.8ICAM1, CXCL11, CXCL9
28polyinosinic-polycytidylic acid4510.8IL12B, CXCL10, TNF
29tyrosine4510.8CCL11, ICAM1, HAVCR1, GYPB, ANGPT2, CXCL10
30ionomycin4510.8CCL11, TNF, CXCL9, IL9
31captopril45 29 50 60 1114.8ACE2, AHSP, CD36
32cyclosporin a45 29 6012.8CCL11, ICAM1, TNF, ANGPT2, CXCL11
33tacrolimus45 50 1112.8CCL11, TNF, CD36, CXCL10
34cdp5714510.8TNF, ICAM1
35infliximab45 50 1112.8CXCL10, ANGPT2, TNF
36peptidoglycan45 2911.7CCL11, TNF, IL12B
37n-formylmethionyl-leucylphenylalanine4510.7TNF, ICAM1, CCL11
38pentoxifylline45 1111.7ICAM1, TNF, IL12B
39phosphatidylinositol4510.7CCL11, ICAM1, ANGPT2, CXCL10, CXCL9, IL12B
40interferon gamma4510.7ICAM1, TNF
41neopterin4510.7CXCL10, TNF, ICAM1
42creatinine4510.7TCN2, CXCL9, CXCL10, CD36, ANGPT2
4315-deoxy-delta-12,14-prostaglandin j24510.6CCL11, TNF, CD36
44allergens4510.6CCL11, CXCL10, IL9
45anti-histamine4510.6ICAM1, CCL11
46oxygen45 2411.5CCL11, ICAM1, TNF, ANGPT2, AHSP, ACE2
4711-deoxy-pge14510.5ICAM1, CD36
48n-tosyl-l-phenylalanine chloromethyl ketone4510.5TNF, ICAM1
49sodium cromoglycate4510.4CCL11, ICAM1
50chloroquine45 2 50 29 1114.2TCN2, CXCL10, TNF

GO Terms for genes affiliated with Cerebral Malaria

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16Gene Ontology
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Cellular components related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:00583310.5HBE1, AHSP
2extracellular spaceGO:00561510.5ACE2, CCL11, ICAM1, TNF, ANGPT2, CXCL11
3external side of plasma membraneGO:00989710.5ICAM1, TNF, CD36, CXCL10, CXCL9
4interleukin-12 complexGO:04351410.4IL12A, IL12B
5extracellular regionGO:00557610.1CCL11, TNF, ANGPT2, CXCL11, CXCL10, CXCL9

Biological processes related to Cerebral Malaria according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.8TNF, CD36, IL12B
2inflammatory responseGO:00695410.8CCL11, TNF, CXCL11, CXCL10, CXCL9, IL9
3negative regulation of smooth muscle cell proliferationGO:04866210.8IL12A, IL12B, KLF4
4positive regulation of interferon-gamma productionGO:03272910.8IL12A, IL12B, TNF
5response to virusGO:00961510.8CCL11, TNF, IL12A, ACE2
6immune responseGO:00695510.8KIR2DL3, CCL11, TNFAIP1, CXCL11, CXCL10, CXCL9
7defense response to Gram-positive bacteriumGO:05083010.8TNF, CD36, IL12A
8chemotaxisGO:00693510.8CCL11, CXCL11, CXCL10, CXCL9
9receptor biosynthetic processGO:03280010.7TNF, ACE2
10positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.7IL12A, IL12B
11virion attachment, binding of host cell surface receptorGO:04681310.7ACE2, ICAM1
12positive regulation of NK T cell activationGO:05113510.7IL12B, IL12A
13positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.7IL12A, IL12B
14positive regulation of lymphocyte proliferationGO:05067110.7IL12A, IL12B
15positive regulation of smooth muscle cell apoptotic processGO:03439310.6IL12B, IL12A
16positive regulation of natural killer cell activationGO:03281610.6IL12B, IL12A
17cellular response to lipopolysaccharideGO:07122210.6IL12B, CD36, ICAM1
18negative regulation of interleukin-17 productionGO:03270010.5IL12A, IL12B
19positive regulation of osteoclast differentiationGO:04567210.5IL12B, TNF
20response to UV-BGO:01022410.5IL12B, IL12A
21positive regulation of leukocyte chemotaxisGO:00269010.4CXCL10, CXCL11
22defense response to protozoanGO:04283210.2IL12A, IL12B

Molecular functions related to Cerebral Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 receptor bindingGO:00514310.5IL12A, IL12B
2chemokine activityGO:00800910.4CXCL9, CXCL10, CXCL11, CCL11
3cytokine activityGO:00512510.4TNF, CXCL9, IL12B, IL12A, IL9
4virus receptor activityGO:00161810.2ACE2, HAVCR1, ICAM1

Products for genes affiliated with Cerebral Malaria

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  • Antibodies
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  • Antibodies

Sources for Cerebral Malaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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