MCID: CRB036
MIFTS: 45

Cerebral Meningioma malady

Cancer diseases category
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Summaries for Cerebral Meningioma

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MalaCards based summary: Cerebral Meningioma, also known as meningioma of cerebrum, is related to meningioma and adenoma. An important gene associated with Cerebral Meningioma is DRD1 (dopamine receptor D1), and among its related pathways are Ovarian Infertility Genes and Signaling events mediated by PTP1B. The compounds cmdb7 and bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include skin and thyroid, and related mouse phenotypes are vision/eye and limbs/digits/tail.

Aliases & Classifications for Cerebral Meningioma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt
See all sources

Cerebral Meningioma, Aliases & Descriptions:

Name: Cerebral Meningioma 8 44 62
 
Meningioma of Cerebrum 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:6112
SNOMED-CT57 189164002
NCIt39 C4807

Related Diseases for Cerebral Meningioma

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Diseases related to Cerebral Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma31.4ESR1, PGR
2adenoma29.7OSM, LIFR, PRLR, IGF1
3leukemia29.3LIFR, PRLR, EGF, OSM, IL6
4cerebritis10.7
5ovarian disease10.4ESR1
6cribriform carcinoma10.3ESR1, PGR
7progesterone resistance10.3ESR1, PGR
8mammary paget's disease10.3PGR, ESR1
9malignant mixed mullerian tumor10.3PGR, ESR1
10bilateral breast cancer10.3PGR, ESR1
11male breast cancer10.3ESR1, PGR
12li-fraumeni syndrome10.3ESR1, PGR
13leiomyomatosis10.3ESR1, PGR
14adenosarcoma10.3PGR, ESR1
15myoma10.3ESR1, PGR
16endometrial stromal sarcoma10.3ESR1, PGR
17uterine fibroid10.3PGR, ESR1
18inflammatory breast carcinoma10.2ESR1, PGR
19lymphangioleiomyomatosis10.2PGR, ESR1
20angiomyolipoma10.2PGR, ESR1
21cervical adenocarcinoma10.2ESR1, PGR
22breast cancer, invasive ductal10.2PGR, ESR1
23ductal carcinoma in situ10.2ESR1, PGR
24gynecomastia10.2PGR, ESR1
25tubular adenocarcinoma10.2PGR, ESR1
26breast ductal carcinoma10.2ESR1, PGR
27donohue syndrome10.2EGF, IGF1
28smooth muscle tumor10.2ESR1, PGR
29breast fibroadenoma10.2ESR1, PGR
30endometrial carcinoma10.2PGR, ESR1
31hyperprolactinemia10.2IGF1, PRLR
32leiomyoma10.1ESR1, PGR, EGF
33osteoporosis, postmenopausal10.1IGF1, ESR1
34infertility10.1LIFR, PRLR, ESR1
35choriocarcinoma10.0OSM, EGF, LIFR
36pituitary adenoma10.0PRLR, IGF1, LIFR
37keratopathy10.0
38actinomycosis10.0
39anorexia nervosa10.0
40papillary carcinoma10.0
41parathyroid adenoma10.0
42thyroiditis10.0
43tremor10.0
44acromegaly10.0IGF1, PRLR
45prolactinoma10.0LIFR, IGF1, ESR1
46breast cancer10.0PGR, ESR1, PRLR, EGF
47glioblastoma9.9PRLR, OSM, EGF
48periodontitis9.9OSM, IL6
49alzheimer's disease9.9IL6, DRD1, OSM
50ovarian cancer9.9PGR, EGF, ESR1

Graphical network of the top 20 diseases related to Cerebral Meningioma:



Diseases related to cerebral meningioma

Symptoms for Cerebral Meningioma

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Drugs & Therapeutics for Cerebral Meningioma

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Drug clinical trials:

Search ClinicalTrials for Cerebral Meningioma

Search NIH Clinical Center for Cerebral Meningioma

Genetic Tests for Cerebral Meningioma

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Anatomical Context for Cerebral Meningioma

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MalaCards organs/tissues related to Cerebral Meningioma:

32
Skin, Thyroid

Animal Models for Cerebral Meningioma or affiliated genes

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Publications for Cerebral Meningioma

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Articles related to Cerebral Meningioma:

(show all 21)
idTitleAuthorsYear
1
Cerebral meningioma presenting as dystonic head tremor. (24259285)
2014
2
Cognitive and emotional problems in patients after cerebral meningioma surgery. (24763925)
2014
3
Unexpected finding of cerebral meningioma on (11)C-PiB PET. (23429388)
2013
4
An incidental finding of cerebral meningioma on 99mTc-TRODAT-1 dopamine transporter SPECT/CT. (22889784)
2012
5
Unexpected finding on I-123 FP-CIT SPECT leading to the diagnosis of cerebral meningioma. (21220989)
2011
6
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
7
An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. (16724700)
2006
8
Radiotherapy after surgery for benign cerebral meningioma. (15066300)
2004
9
Can the calcitonin used for a shoulder-hand syndrome have a role in the revelation of a cerebral meningioma? (15589451)
2004
10
Estrogen and progesterone receptors in cerebral meningioma and their clinical value]. (12378940)
2002
11
Radiation-induced skin ulcer, cerebral meningioma, and skin cancer following radiation and radium treatment for actinomycosis. (11994636)
2002
12
"Anorexia saved my life": coincidental anorexia nervosa and cerebral meningioma. (11746295)
2001
13
Post-operative computed tomography in two dogs with cerebral meningioma. (11052366)
2000
14
Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. (9488310)
1998
15
Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. (7897522)
1995
16
Results of craniotomy for the treatment of cerebral meningioma in 42 cats. (8191679)
1994
17
Presence of dopamine D1 receptors and absence of dopamine D2 receptors in human cerebral meningioma tissue. (1385626)
1992
18
Hormonal dependency of cerebral meningiomas. Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas. (2213165)
1990
19
Hormonal dependency of cerebral meningiomas. Part 1: Female sex steroid receptors and their significance as specific markers for adjuvant medical therapy. (2213164)
1990
20
Radiation-induced cerebral meningioma: a recognizable entity. (6593438)
1984
21
Foot and leg symptoms referrable to bilateral cerebral meningioma--a case report. (14028016)
1962

Variations for Cerebral Meningioma

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Expression for genes affiliated with Cerebral Meningioma

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Expression patterns in normal tissues for genes affiliated with Cerebral Meningioma

Search GEO for disease gene expression data for Cerebral Meningioma.

Pathways for genes affiliated with Cerebral Meningioma

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Pathways related to Cerebral Meningioma according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PRLR, PGR
29.7EGF, PRLR
39.5IGF1, EGF
49.5LIFR, OSM
59.3IGF1, IL6
6
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.3ESR1, PRLR
7
Show member pathways
Nuclear Receptors37
9.3ESR1, PGR
8
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.3PGR, ESR1
99.2ESR1, EGF
10
Show member pathways
9.2PRLR, IGF1, EGF
11
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1LIFR, IGF1, EGF
12
Show member pathways
8.9PGR, PRLR, ESR1
13
Show member pathways
8.9EGF, IGF1, IL6
14
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
8.9IGF1, EGF, IL6
15
Show member pathways
8.9EGF, IGF1, IL6
16
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.9IGF1, EGF, IL6
17
Show member pathways
8.9IL6, IGF1, EGF
188.9IL6, EGF, IGF1
198.9IL6, EGF, IGF1
20
Show member pathways
8.9IGF1, LIFR, IL6
218.7EGF, ESR1, IGF1
22
Show member pathways
Type III interferon signaling37
8.5PRLR, LIFR, OSM, IL6
23
Show member pathways
8.5PGR, ESR1, PRLR, EGF
24
Show member pathways
8.5EGF, IGF1, LIFR, IL6
25
Show member pathways
8.5EGF, IL6, LIFR, IGF1
26
Show member pathways
8.5IL6, EGF, LIFR, IGF1
27
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
8.4DRD1, IGF1, ESR1, EGF
28
Show member pathways
8.1LIFR, IGF1, EGF, PRLR, IL6
29
Show member pathways
8.1OSM, LIFR, PRLR, IL6, EGF
308.1IL6, PRLR, OSM, EGF, IGF1
318.0PRLR, IGF1, OSM, LIFR, IL6
32
Show member pathways
7.9IL6, EGF, LIFR, IGF1, OSM
33
Show member pathways
7.9EGF, IL6, LIFR, IGF1, OSM
34
Show member pathways
7.7IGF1, PGR, ESR1, PRLR, DRD1, EGF
35
Show member pathways
7.6EGF, ESR1, IGF1, LIFR, IL6
36
Show member pathways
7.6EGF, IL6, LIFR, ESR1, IGF1
37
Show member pathways
7.1IGF1, EGF, ESR1, LIFR, OSM, IL6

Compounds for genes affiliated with Cerebral Meningioma

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Compounds related to Cerebral Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1cmdb7449.7IGF1, EGF
2bromocriptine44 28 1111.6PRLR, DRD1, IGF1
3ici 164384449.6ESR1, PGR
4idoxifene449.6PGR, ESR1
5triphenylethylene449.5PGR, ESR1
6fluoxymesterone44 1110.5ESR1, PRLR
7norgestimate44 1110.3PGR, ESR1
8dichlorodiphenyltrichloroethane449.3OSM, ESR1
9progestins449.3PRLR, PGR, ESR1
10lapatinib44 50 1111.3PGR, ESR1, EGF
11fulvestrant44 50 28 1112.2PGR, ESR1, EGF
12nandrolone44 2410.2IGF1, PGR, ESR1
13droloxifene449.2IGF1, ESR1, PGR
14leuprolide acetate449.2ESR1, PGR, IGF1
15trastuzumab44 50 1111.2ESR1, PGR, EGF
16clomiphene citrate449.2PGR, IGF1, ESR1
17letrozole44 50 61 1112.1ESR1, PGR, IGF1
18estrone sulfate44 2410.1IGF1, ESR1, PGR
19raloxifene44 50 28 1112.1IGF1, PGR, ESR1
20indomethacin44 28 61 1111.9OSM, EGF, PGR, IL6
21geldanamycin44 50 61 1111.9EGF, ESR1, PGR
224-hydroxytamoxifen448.8EGF, IGF1, PGR, ESR1
23mifepristone44 28 61 1111.8ESR1, PGR, EGF
24estrone44 28 24 1111.8PGR, ESR1, IGF1
25dihydrotestosterone44 28 24 1111.7EGF, ESR1, PGR, IGF1
26acth448.7OSM, IGF1, LIFR, IL6
27paclitaxel44 50 1110.7PGR, EGF, LIFR, ESR1
28phosphatidylinositol448.7IGF1, PRLR, DRD1, EGF, OSM
29pd 98,059448.7OSM, EGF, IL6, IGF1
30cysteine448.6DRD1, EGF, PRLR, PGR, OSM
31megestrol acetate448.6IGF1, IL6, ESR1, PGR
32gp 130448.6OSM, IL6, LIFR
33alanine448.4LIFR, IL6, OSM, PGR, PRLR
34progestin448.4PGR, IGF1, EGF, PRLR, ESR1
35thymidine44 249.4IL6, PRLR, OSM, EGF, IGF1
36tamoxifen44 50 28 1111.4PRLR, ESR1, PGR, IGF1, EGF
37ly294002448.3IGF1, ESR1, IL6, EGF
38actinomycin d448.3EGF, IGF1, ESR1, IL6
39gnrh448.1IGF1, DRD1, EGF, PRLR, ESR1, PGR
40dexamethasone44 50 28 1111.1EGF, IL6, PRLR, PGR, OSM, IGF1
41progesterone44 28 61 24 1112.0LIFR, PRLR, ESR1, PGR, IGF1, EGF
42testosterone44 61 24 1110.8IL6, PRLR, PGR, IGF1, ESR1, EGF
43tyrosine447.7EGF, DRD1, IL6, PRLR, LIFR, OSM
44vegf447.6ESR1, PGR, IL6, OSM, IGF1, EGF
45estradiol44 24 119.6OSM, PGR, ESR1, PRLR, DRD1, IGF1
46retinoic acid44 248.6PGR, IGF1, IL6, ESR1, EGF, OSM
47steroid447.5IGF1, OSM, PGR, ESR1, LIFR, PRLR
48cycloheximide447.3EGF, OSM, IGF1, PGR, ESR1, PRLR
49genistein44 28 61 2 24 1112.0EGF, IL6, PRLR, ESR1, PGR, OSM
50estrogen446.5IGF1, OSM, PGR, ESR1, LIFR, PRLR

GO Terms for genes affiliated with Cerebral Meningioma

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Cellular components related to Cerebral Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5EGF, IGF1
2extracellular spaceGO:0056158.1IGF1, OSM, IL6, EGF
3extracellular regionGO:0055768.0EGF, IL6, PRLR, LIFR, IGF1

Biological processes related to Cerebral Meningioma according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1activation of transmembrane receptor protein tyrosine kinase activityGO:00717110.1EGF, PRLR
2positive regulation of cerebellar granule cell precursor proliferationGO:0219409.9EGF, IGF1
3positive regulation of DNA bindingGO:0433889.9EGF, IGF1
4branching morphogenesis of an epithelial tubeGO:0487549.8IGF1, EGF
5positive regulation of mitosisGO:0458409.8IGF1, EGF
6positive regulation of acute inflammatory responseGO:0026759.7OSM, IL6
7negative regulation of hormone secretionGO:0468889.7IL6, OSM
8positive regulation of protein import into nucleus, translocationGO:0331609.7IL6, IGF1
9mammary gland alveolus developmentGO:0607499.6ESR1, EGF
10positive regulation of DNA replicationGO:0457409.6IL6, IGF1
11response to heatGO:0094089.5IL6, OSM
12positive regulation of smooth muscle cell proliferationGO:0486619.5IGF1, IL6
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGO:0605279.5ESR1, IGF1
14positive regulation of peptidyl-serine phosphorylationGO:0331389.4IL6, OSM
15positive regulation of osteoblast differentiationGO:0456699.3IGF1, IL6
16positive regulation of nitric oxide biosynthetic processGO:0454299.3IL6, ESR1
17positive regulation of fibroblast proliferationGO:0481469.3ESR1, IGF1
18negative regulation of gene expressionGO:0106299.3ESR1, PGR
19positive regulation of epithelial cell proliferationGO:0506799.2IL6, IGF1
20platelet activationGO:0301689.2EGF, IL6, IGF1
21positive regulation of MAPK cascadeGO:0434109.2IGF1, OSM, IL6
22positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2IL6, OSM, IGF1
23positive regulation of protein kinase B signalingGO:0518979.0IL6, IGF1
24negative regulation of cell proliferationGO:0082858.9IL6, OSM, IGF1
25signal transductionGO:0071658.6IGF1, PGR, ESR1, EGF
26positive regulation of cell proliferationGO:0082848.3EGF, IL6, LIFR, OSM, IGF1
27positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IGF1, OSM, ESR1, IL6

Molecular functions related to Cerebral Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.3ESR1, PGR
2steroid bindingGO:0054969.2ESR1, PGR
3growth factor activityGO:0080838.4EGF, IL6, OSM, IGF1
4protein bindingGO:0055156.8IGF1, PGR, ESR1, PRLR, IL6, DRD1

Products for genes affiliated with Cerebral Meningioma

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Sources for Cerebral Meningioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet