MCID: CRB036
MIFTS: 45

Cerebral Meningioma malady

Cancer diseases category
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Summaries for Cerebral Meningioma

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33MalaCards
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MalaCards: Cerebral Meningioma, also known as meningioma of cerebrum, is related to meningioma and adenoma. An important gene associated with Cerebral Meningioma is DRD1 (dopamine receptor D1), and among its related pathways are Ovarian Infertility Genes and Signaling events mediated by PTP1B. The compounds cmdb7 and bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include skin and thyroid, and related mouse phenotypes are vision/eye and limbs/digits/tail.

Aliases & Classifications for Cerebral Meningioma

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cerebral meningioma 8 45 62
meningioma of cerebrum 8


External Ids:

Disease Ontology8 DOID:6112
SNOMED-CT58 189164002
NCIt40 C4807

Related Diseases for Cerebral Meningioma

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma31.1ESR1, PGR
2adenoma29.9OSM, LIFR, PRLR, IGF1
3leukemia29.8LIFR, PRLR, EGF, OSM, IL6
4cerebritis10.7
5ovarian disease10.1ESR1
6cribriform carcinoma10.1ESR1, PGR
7progesterone resistance10.1ESR1, PGR
8mammary paget's disease10.1PGR, ESR1
9malignant mixed mullerian tumor10.1PGR, ESR1
10bilateral breast cancer10.1PGR, ESR1
11male breast cancer10.1ESR1, PGR
12li-fraumeni syndrome10.1ESR1, PGR
13leiomyomatosis10.1ESR1, PGR
14adenosarcoma10.1PGR, ESR1
15myoma10.1ESR1, PGR
16endometrial stromal sarcoma10.1ESR1, PGR
17uterine fibroid10.1PGR, ESR1
18inflammatory breast carcinoma10.1ESR1, PGR
19lymphangioleiomyomatosis10.1PGR, ESR1
20angiomyolipoma10.1PGR, ESR1
21cervical adenocarcinoma10.1ESR1, PGR
22breast cancer, invasive ductal10.1PGR, ESR1
23ductal carcinoma in situ10.1ESR1, PGR
24gynecomastia10.1PGR, ESR1
25tubular adenocarcinoma10.0PGR, ESR1
26donohue syndrome10.0EGF, IGF1
27smooth muscle tumor10.0ESR1, PGR
28breast fibroadenoma10.0ESR1, PGR
29endometrial carcinoma10.0PGR, ESR1
30hyperprolactinemia10.0IGF1, PRLR
31leiomyoma10.0ESR1, PGR, EGF
32osteoporosis, postmenopausal10.0IGF1, ESR1
33infertility10.0LIFR, PRLR, ESR1
34choriocarcinoma10.0OSM, EGF, LIFR
35pituitary adenoma10.0PRLR, IGF1, LIFR
36actinomycosis10.0
37anorexia nervosa10.0
38papillary carcinoma10.0
39keratopathy10.0
40parathyroid adenoma10.0
41thyroiditis10.0
42tremor10.0
43acromegaly10.0IGF1, PRLR
44prolactinoma10.0LIFR, IGF1, ESR1
45breast cancer10.0PGR, ESR1, PRLR, EGF
46glioblastoma multiforme10.0PRLR, OSM, EGF
47periodontitis10.0OSM, IL6
48alzheimer's disease10.0IL6, DRD1, OSM
49ovarian cancer10.0PGR, EGF, ESR1
50plasmacytoma10.0IL6, LIFR, OSM

Graphical network of the top 20 diseases related to Cerebral Meningioma:



Diseases related to cerebral meningioma

Symptoms for Cerebral Meningioma

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Drugs & Therapeutics for Cerebral Meningioma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cerebral Meningioma

Search NIH Clinical Center for Cerebral Meningioma

Genetic Tests for Cerebral Meningioma

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Anatomical Context for Cerebral Meningioma

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33MalaCards
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MalaCards organs/tissues related to Cerebral Meningioma:

33
Skin, Thyroid

Animal Models for Cerebral Meningioma or affiliated genes

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37MGI
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Publications for Cerebral Meningioma

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52PubMed
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Articles related to Cerebral Meningioma:

(show all 20)
idTitleAuthorsYear
1
Cerebral meningioma presenting as dystonic head tremor. (24259285)
2014
2
Unexpected finding of cerebral meningioma on (11)C-PiB PET. (23429388)
2013
3
An incidental finding of cerebral meningioma on 99mTc-TRODAT-1 dopamine transporter SPECT/CT. (22889784)
2012
4
Unexpected finding on I-123 FP-CIT SPECT leading to the diagnosis of cerebral meningioma. (21220989)
2011
5
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
6
An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. (16724700)
2006
7
Radiotherapy after surgery for benign cerebral meningioma. (15066300)
2004
8
Can the calcitonin used for a shoulder-hand syndrome have a role in the revelation of a cerebral meningioma? (15589451)
2004
9
Estrogen and progesterone receptors in cerebral meningioma and their clinical value]. (12378940)
2002
10
Radiation-induced skin ulcer, cerebral meningioma, and skin cancer following radiation and radium treatment for actinomycosis. (11994636)
2002
11
"Anorexia saved my life": coincidental anorexia nervosa and cerebral meningioma. (11746295)
2001
12
Post-operative computed tomography in two dogs with cerebral meningioma. (11052366)
2000
13
Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. (9488310)
1998
14
Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. (7897522)
1995
15
Results of craniotomy for the treatment of cerebral meningioma in 42 cats. (8191679)
1994
16
Presence of dopamine D1 receptors and absence of dopamine D2 receptors in human cerebral meningioma tissue. (1385626)
1992
17
Hormonal dependency of cerebral meningiomas. Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas. (2213165)
1990
18
Hormonal dependency of cerebral meningiomas. Part 1: Female sex steroid receptors and their significance as specific markers for adjuvant medical therapy. (2213164)
1990
19
Radiation-induced cerebral meningioma: a recognizable entity. (6593438)
1984
20
Foot and leg symptoms referrable to bilateral cerebral meningioma--a case report. (14028016)
1962

Variations for Cerebral Meningioma

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Expression for genes affiliated with Cerebral Meningioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Meningioma

Search GEO for disease gene expression data for Cerebral Meningioma.

Pathways for genes affiliated with Cerebral Meningioma

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 53QIAGEN, 30KEGG
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Pathways related to Cerebral Meningioma according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PGR, PRLR
29.7PRLR, EGF
39.5EGF, IGF1
49.5OSM, LIFR
59.3IGF1, IL6
6
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.3ESR1, PRLR
7
Show member pathways
Nuclear Receptors38
9.3ESR1, PGR
8
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.3ESR1, PGR
99.2EGF, ESR1
10
Show member pathways
9.2EGF, PRLR, IGF1
11
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1EGF, LIFR, IGF1
12
Show member pathways
8.9PRLR, ESR1, PGR
13
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
8.9EGF, IL6, IGF1
14
Show member pathways
8.9EGF, IL6, IGF1
158.9EGF, IL6, IGF1
16
Show member pathways
8.9EGF, IL6, IGF1
17
Show member pathways
8.9EGF, IL6, IGF1
18
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
8.9IGF1, IL6, EGF
198.9IGF1, IL6, EGF
20
Show member pathways
8.9IL6, LIFR, IGF1
218.7EGF, ESR1, IGF1
22
Show member pathways
Type III interferon signaling38
8.5IL6, PRLR, LIFR, OSM
23
Show member pathways
8.5PGR, ESR1, PRLR, EGF
24
Show member pathways
8.5IGF1, LIFR, IL6, EGF
25
Show member pathways
8.5IGF1, LIFR, IL6, EGF
26
Show member pathways
8.5EGF, IL6, LIFR, IGF1
27
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
8.4EGF, DRD1, ESR1, IGF1
28
Show member pathways
8.1IGF1, LIFR, PRLR, IL6, EGF
29
Show member pathways
8.1EGF, IL6, PRLR, LIFR, OSM
308.1IGF1, OSM, PRLR, IL6, EGF
318.0IL6, PRLR, LIFR, OSM, IGF1
32
Show member pathways
7.9IGF1, OSM, LIFR, IL6, EGF
33
Show member pathways
7.9IL6, LIFR, OSM, IGF1, EGF
34
Show member pathways
7.7IGF1, PGR, ESR1, PRLR, DRD1, EGF
35
Show member pathways
7.6IGF1, ESR1, LIFR, IL6, EGF
36
Show member pathways
7.6IGF1, ESR1, LIFR, IL6, EGF
37
Show member pathways
7.1IGF1, OSM, ESR1, LIFR, IL6, EGF

Compounds for genes affiliated with Cerebral Meningioma

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Cerebral Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1cmdb7459.7IGF1, EGF
2bromocriptine45 29 1111.6PRLR, DRD1, IGF1
3ici 164384459.6ESR1, PGR
4idoxifene459.6PGR, ESR1
5triphenylethylene459.5PGR, ESR1
6fluoxymesterone45 1110.5ESR1, PRLR
7norgestimate45 1110.3PGR, ESR1
8dichlorodiphenyltrichloroethane459.3OSM, ESR1
9progestins459.3PRLR, PGR, ESR1
10lapatinib45 51 1111.3PGR, ESR1, EGF
11fulvestrant45 51 29 1112.2PGR, ESR1, EGF
12nandrolone45 2410.2IGF1, PGR, ESR1
13droloxifene459.2IGF1, ESR1, PGR
14leuprolide acetate459.2ESR1, PGR, IGF1
15trastuzumab45 51 1111.2ESR1, PGR, EGF
16clomiphene citrate459.2PGR, IGF1, ESR1
17letrozole45 51 61 1112.1ESR1, PGR, IGF1
18estrone sulfate45 2410.1IGF1, ESR1, PGR
19raloxifene45 51 29 1112.1IGF1, PGR, ESR1
20indomethacin45 29 61 1111.9OSM, EGF, PGR, IL6
21geldanamycin45 51 61 1111.9EGF, ESR1, PGR
224-hydroxytamoxifen458.8EGF, IGF1, PGR, ESR1
23mifepristone45 29 61 1111.8ESR1, PGR, EGF
24estrone45 29 24 1111.8PGR, ESR1, IGF1
25dihydrotestosterone45 29 24 1111.7EGF, ESR1, PGR, IGF1
26acth458.7OSM, IGF1, LIFR, IL6
27paclitaxel45 51 1110.7PGR, EGF, LIFR, ESR1
28phosphatidylinositol458.7IGF1, PRLR, DRD1, EGF, OSM
29pd 98,059458.7OSM, EGF, IL6, IGF1
30cysteine458.6DRD1, EGF, PRLR, PGR, OSM
31megestrol acetate458.6IGF1, IL6, ESR1, PGR
32gp 130458.6OSM, IL6, LIFR
33alanine458.4LIFR, IL6, OSM, PGR, PRLR
34progestin458.4PGR, IGF1, EGF, PRLR, ESR1
35thymidine45 249.4IL6, PRLR, OSM, EGF, IGF1
36tamoxifen45 51 29 1111.4PRLR, ESR1, PGR, IGF1, EGF
37ly294002458.3IGF1, ESR1, IL6, EGF
38actinomycin d458.3EGF, IGF1, ESR1, IL6
39gnrh458.1IGF1, DRD1, EGF, PRLR, ESR1, PGR
40dexamethasone45 51 29 1111.1EGF, IL6, PRLR, PGR, OSM, IGF1
41progesterone45 29 61 24 1112.0LIFR, PRLR, ESR1, PGR, IGF1, EGF
42testosterone45 61 24 1110.8IL6, PRLR, PGR, IGF1, ESR1, EGF
43tyrosine457.7EGF, DRD1, IL6, PRLR, LIFR, OSM
44vegf457.6ESR1, PGR, IL6, OSM, IGF1, EGF
45estradiol45 24 119.6OSM, PGR, ESR1, PRLR, DRD1, IGF1
46retinoic acid45 248.6PGR, IGF1, IL6, ESR1, EGF, OSM
47steroid457.5IGF1, OSM, PGR, ESR1, LIFR, PRLR
48cycloheximide457.3EGF, OSM, IGF1, PGR, ESR1, PRLR
49genistein45 29 61 3 24 1112.0EGF, IL6, PRLR, ESR1, PGR, OSM
50estrogen456.5IGF1, OSM, PGR, ESR1, LIFR, PRLR

GO Terms for genes affiliated with Cerebral Meningioma

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16Gene Ontology
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Cellular components related to Cerebral Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5EGF, IGF1
2extracellular spaceGO:0056158.1IGF1, OSM, IL6, EGF
3extracellular regionGO:0055768.0EGF, IL6, PRLR, LIFR, IGF1

Biological processes related to Cerebral Meningioma according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1activation of transmembrane receptor protein tyrosine kinase activityGO:00717110.1EGF, PRLR
2positive regulation of cerebellar granule cell precursor proliferationGO:0219409.9EGF, IGF1
3positive regulation of DNA bindingGO:0433889.9EGF, IGF1
4branching morphogenesis of an epithelial tubeGO:0487549.8IGF1, EGF
5positive regulation of mitosisGO:0458409.8IGF1, EGF
6positive regulation of acute inflammatory responseGO:0026759.7OSM, IL6
7negative regulation of hormone secretionGO:0468889.7IL6, OSM
8positive regulation of protein import into nucleus, translocationGO:0331609.7IL6, IGF1
9mammary gland alveolus developmentGO:0607499.6ESR1, EGF
10positive regulation of DNA replicationGO:0457409.6IL6, IGF1
11response to heatGO:0094089.5IL6, OSM
12positive regulation of smooth muscle cell proliferationGO:0486619.5IGF1, IL6
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGO:0605279.5ESR1, IGF1
14positive regulation of peptidyl-serine phosphorylationGO:0331389.4IL6, OSM
15positive regulation of osteoblast differentiationGO:0456699.3IGF1, IL6
16positive regulation of nitric oxide biosynthetic processGO:0454299.3IL6, ESR1
17positive regulation of fibroblast proliferationGO:0481469.3ESR1, IGF1
18negative regulation of gene expressionGO:0106299.3ESR1, PGR
19positive regulation of epithelial cell proliferationGO:0506799.2IL6, IGF1
20platelet activationGO:0301689.2EGF, IL6, IGF1
21positive regulation of MAPK cascadeGO:0434109.2IGF1, OSM, IL6
22positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2IL6, OSM, IGF1
23positive regulation of protein kinase B signalingGO:0518979.0IL6, IGF1
24negative regulation of cell proliferationGO:0082858.9IL6, OSM, IGF1
25signal transductionGO:0071658.6IGF1, PGR, ESR1, EGF
26positive regulation of cell proliferationGO:0082848.3EGF, IL6, LIFR, OSM, IGF1
27positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IGF1, OSM, ESR1, IL6

Molecular functions related to Cerebral Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.3PGR, ESR1
2steroid bindingGO:0054969.2ESR1, PGR
3growth factor activityGO:0080838.4IGF1, OSM, IL6, EGF
4protein bindingGO:0055156.8IGF1, PGR, ESR1, PRLR, IL6, DRD1

Products for genes affiliated with Cerebral Meningioma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Meningioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet