MCID: CRB036
MIFTS: 37

Cerebral Meningioma malady

Summaries for Cerebral Meningioma

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MalaCards based summary: Cerebral Meningioma, also known as meningioma of cerebrum, is related to adenoma and leukemia. An important gene associated with Cerebral Meningioma is DRD1 (dopamine receptor D1), and among its related pathways are Ovarian Infertility Genes and Signaling events mediated by PTP1B. The compounds cmdb7 and bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include skin and thyroid, and related mouse phenotypes are vision/eye and limbs/digits/tail.

Aliases & Classifications for Cerebral Meningioma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT
See all sources

Cerebral Meningioma, Aliases & Descriptions:

Name: Cerebral Meningioma 9 43 60
 
Meningioma of Cerebrum 9


External Ids:

Disease Ontology9 DOID:6112
SNOMED-CT55 189164002
NCIt38 C4807

Related Diseases for Cerebral Meningioma

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Diseases related to Cerebral Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma29.7PRLR, LIFR, OSM, IGF1
2leukemia29.3OSM, LIFR, PRLR, IL6, EGF
3cerebritis10.7
4ovarian disease10.4ESR1
5meningioma, familial10.3PGR, ESR1
6cribriform carcinoma10.3PGR, ESR1
7progesterone resistance10.3PGR, ESR1
8mammary paget's disease10.3PGR, ESR1
9malignant mixed mullerian tumor10.3PGR, ESR1
10bilateral breast cancer10.3ESR1, PGR
11leiomyomatosis10.3PGR, ESR1
12adenosarcoma10.3PGR, ESR1
13breast disease10.3PGR, ESR1
14myoma10.3ESR1, PGR
15endometrial stromal sarcoma10.2ESR1, PGR
16uterine fibroid10.2ESR1, PGR
17inflammatory breast carcinoma10.2ESR1, PGR
18lymphangioleiomyomatosis10.2ESR1, PGR
19angiomyolipoma10.2ESR1, PGR
20cervical adenocarcinoma10.2PGR, ESR1
21breast cancer10.2PGR, ESR1
22gynecomastia10.2ESR1, PGR
23ductal carcinoma in situ10.2ESR1, PGR
24tubular adenocarcinoma10.2PGR, ESR1
25breast ductal carcinoma10.2ESR1, PGR
26smooth muscle tumor10.2PGR, ESR1
27leprechaunism10.2IGF1, EGF
28breast fibroadenoma10.2PGR, ESR1
29endometrial cancer10.2ESR1, PGR
30hyperprolactinemia10.2PRLR, IGF1
31classic kaposi sarcoma10.2IL6
32li-fraumeni syndrome10.1PGR, ESR1, PRLR
33osteoporosis10.1IGF1, ESR1
34leiomyoma10.1EGF, ESR1, PGR
35infertility10.1ESR1, LIFR, PRLR
36acromegaly10.0PRLR, IGF1
37choriocarcinoma10.0OSM, LIFR, EGF
38pituitary adenoma10.0PRLR, LIFR, IGF1
39anorexia nervosa10.0
40keratopathy10.0
41actinomycosis10.0
42papillary carcinoma10.0
43parathyroid adenoma10.0
44thyroiditis10.0
45tremor10.0
46prolactinoma10.0LIFR, ESR1, IGF1
47periodontitis9.9IL6, OSM
48ovarian cancer, somatic9.9PGR, ESR1, EGF
49glioblastoma9.9EGF, PRLR, OSM
50alzheimer disease9.9OSM, IL6, DRD1

Graphical network of the top 20 diseases related to Cerebral Meningioma:



Diseases related to cerebral meningioma

Symptoms for Cerebral Meningioma

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Drugs & Therapeutics for Cerebral Meningioma

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Drug clinical trials:

Search ClinicalTrials for Cerebral Meningioma

Search NIH Clinical Center for Cerebral Meningioma

Genetic Tests for Cerebral Meningioma

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Anatomical Context for Cerebral Meningioma

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MalaCards organs/tissues related to Cerebral Meningioma:

31
Skin, Thyroid

Animal Models for Cerebral Meningioma or affiliated genes

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Publications for Cerebral Meningioma

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Articles related to Cerebral Meningioma:

(show all 21)
idTitleAuthorsYear
1
Cerebral meningioma presenting as dystonic head tremor. (24259285)
2014
2
Cognitive and emotional problems in patients after cerebral meningioma surgery. (24763925)
2014
3
Unexpected finding of cerebral meningioma on (11)C-PiB PET. (23429388)
2013
4
An incidental finding of cerebral meningioma on 99mTc-TRODAT-1 dopamine transporter SPECT/CT. (22889784)
2012
5
Unexpected finding on I-123 FP-CIT SPECT leading to the diagnosis of cerebral meningioma. (21220989)
2011
6
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
7
An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. (16724700)
2006
8
Radiotherapy after surgery for benign cerebral meningioma. (15066300)
2004
9
Can the calcitonin used for a shoulder-hand syndrome have a role in the revelation of a cerebral meningioma? (15589451)
2004
10
Estrogen and progesterone receptors in cerebral meningioma and their clinical value]. (12378940)
2002
11
Radiation-induced skin ulcer, cerebral meningioma, and skin cancer following radiation and radium treatment for actinomycosis. (11994636)
2002
12
"Anorexia saved my life": coincidental anorexia nervosa and cerebral meningioma. (11746295)
2001
13
Post-operative computed tomography in two dogs with cerebral meningioma. (11052366)
2000
14
Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. (9488310)
1998
15
Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. (7897522)
1995
16
Results of craniotomy for the treatment of cerebral meningioma in 42 cats. (8191679)
1994
17
Presence of dopamine D1 receptors and absence of dopamine D2 receptors in human cerebral meningioma tissue. (1385626)
1992
18
Hormonal dependency of cerebral meningiomas. Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas. (2213165)
1990
19
Hormonal dependency of cerebral meningiomas. Part 1: Female sex steroid receptors and their significance as specific markers for adjuvant medical therapy. (2213164)
1990
20
Radiation-induced cerebral meningioma: a recognizable entity. (6593438)
1984
21
Foot and leg symptoms referrable to bilateral cerebral meningioma--a case report. (14028016)
1962

Variations for Cerebral Meningioma

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Expression for genes affiliated with Cerebral Meningioma

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Search GEO for disease gene expression data for Cerebral Meningioma.

Pathways for genes affiliated with Cerebral Meningioma

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Pathways related to Cerebral Meningioma according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PGR, PRLR
29.7PRLR, EGF
39.5EGF, IGF1
49.5OSM, LIFR
59.3IGF1, IL6
6
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway58
9.3ESR1, PRLR
7
Show member pathways
Nuclear Receptors36
9.3ESR1, PGR
8
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.3ESR1, PGR
99.2EGF, ESR1
10
Show member pathways
9.2EGF, PRLR, IGF1
11
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.1EGF, LIFR, IGF1
12
Show member pathways
8.9PRLR, ESR1, PGR
13
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
8.9EGF, IL6, IGF1
14
Show member pathways
8.9EGF, IL6, IGF1
158.9EGF, IL6, IGF1
16
Show member pathways
8.9EGF, IL6, IGF1
17
Show member pathways
8.9EGF, IL6, IGF1
18
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
8.9IGF1, IL6, EGF
198.9IGF1, IL6, EGF
20
Show member pathways
8.9IL6, LIFR, IGF1
218.7EGF, ESR1, IGF1
22
Show member pathways
Type III interferon signaling36
8.5IL6, PRLR, LIFR, OSM
23
Show member pathways
8.5PGR, ESR1, PRLR, EGF
24
Show member pathways
8.5IGF1, LIFR, IL6, EGF
25
Show member pathways
8.5IGF1, LIFR, IL6, EGF
26
Show member pathways
8.5EGF, IL6, LIFR, IGF1
27
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
8.4EGF, DRD1, ESR1, IGF1
28
Show member pathways
8.1IGF1, LIFR, PRLR, IL6, EGF
29
Show member pathways
8.1EGF, IL6, PRLR, LIFR, OSM
308.1IGF1, OSM, PRLR, IL6, EGF
318.0IL6, PRLR, LIFR, OSM, IGF1
32
Show member pathways
7.9IGF1, OSM, LIFR, IL6, EGF
33
Show member pathways
7.9IL6, LIFR, OSM, IGF1, EGF
34
Show member pathways
7.7IGF1, PGR, ESR1, PRLR, DRD1, EGF
35
Show member pathways
7.6IGF1, ESR1, LIFR, IL6, EGF
36
Show member pathways
7.6IGF1, ESR1, LIFR, IL6, EGF
37
Show member pathways
7.1IGF1, OSM, ESR1, LIFR, IL6, EGF

Compounds for genes affiliated with Cerebral Meningioma

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Compounds related to Cerebral Meningioma according to GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1cmdb7439.7IGF1, EGF
2bromocriptine43 28 1211.6DRD1, PRLR, IGF1
3ici 164384439.6PGR, ESR1
4idoxifene439.6PGR, ESR1
5triphenylethylene439.5ESR1, PGR
6fluoxymesterone43 1210.5ESR1, PRLR
7norgestimate43 1210.3PGR, ESR1
8dichlorodiphenyltrichloroethane439.3OSM, ESR1
9progestins439.3PRLR, ESR1, PGR
10lapatinib43 49 1211.3EGF, ESR1, PGR
11fulvestrant43 49 28 1212.2EGF, ESR1, PGR
12droloxifene439.2IGF1, PGR, ESR1
13nandrolone43 2410.2IGF1, PGR, ESR1
14leuprolide acetate439.2ESR1, PGR, IGF1
15trastuzumab43 49 1211.2PGR, ESR1, EGF
16clomiphene citrate439.2IGF1, PGR, ESR1
17letrozole43 49 59 1212.1IGF1, PGR, ESR1
18estrone sulfate43 2410.1ESR1, PGR, IGF1
19raloxifene43 49 28 1212.1ESR1, PGR, IGF1
20indomethacin43 28 59 1211.9OSM, PGR, IL6, EGF
21geldanamycin43 49 59 1211.9EGF, ESR1, PGR
224-hydroxytamoxifen438.8EGF, ESR1, PGR, IGF1
23mifepristone43 28 59 1211.8PGR, ESR1, EGF
24estrone43 28 24 1211.8ESR1, PGR, IGF1
25dihydrotestosterone43 28 24 1211.7EGF, ESR1, PGR, IGF1
26acth438.7IGF1, OSM, LIFR, IL6
27paclitaxel43 49 1210.7EGF, LIFR, ESR1, PGR
28phosphatidylinositol438.7IGF1, OSM, PRLR, DRD1, EGF
29pd 98,059438.7IGF1, OSM, IL6, EGF
30cysteine438.6EGF, DRD1, PRLR, PGR, OSM
31megestrol acetate438.6IGF1, PGR, ESR1, IL6
32gp 130438.6IL6, LIFR, OSM
33alanine438.4OSM, PGR, LIFR, PRLR, IL6
34progestin438.4IGF1, PGR, ESR1, PRLR, EGF
35thymidine43 249.4IGF1, OSM, PRLR, IL6, EGF
36tamoxifen43 49 28 1211.4IGF1, PGR, ESR1, PRLR, EGF
37ly294002438.3EGF, IL6, ESR1, IGF1
38actinomycin d438.3EGF, IL6, ESR1, IGF1
39gnrh438.1IGF1, PGR, ESR1, PRLR, DRD1, EGF
40dexamethasone43 49 28 1211.1IGF1, OSM, PGR, PRLR, IL6, EGF
41progesterone43 28 59 24 1212.0IGF1, PGR, ESR1, LIFR, PRLR, EGF
42testosterone43 59 24 1210.8IGF1, PGR, ESR1, PRLR, IL6, EGF
43tyrosine437.7IGF1, OSM, LIFR, PRLR, IL6, DRD1
44vegf437.6IGF1, OSM, PGR, ESR1, IL6, EGF
45estradiol43 24 129.6IGF1, OSM, PGR, ESR1, PRLR, DRD1
46retinoic acid43 248.6IGF1, OSM, PGR, ESR1, IL6, EGF
47steroid437.5IGF1, OSM, PGR, ESR1, LIFR, PRLR
48cycloheximide437.3IGF1, OSM, PGR, ESR1, PRLR, IL6
49genistein43 28 59 2 24 1212.0EGF, IGF1, OSM, PGR, ESR1, PRLR
50estrogen436.5IGF1, OSM, PGR, ESR1, LIFR, PRLR

GO Terms for genes affiliated with Cerebral Meningioma

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Cellular components related to Cerebral Meningioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.5EGF, IGF1
2extracellular spaceGO:00056158.1IGF1, OSM, IL6, EGF
3extracellular regionGO:00055768.0EGF, IL6, PRLR, LIFR, IGF1

Biological processes related to Cerebral Meningioma according to GeneCards Suite gene sharing:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1activation of transmembrane receptor protein tyrosine kinase activityGO:000717110.1EGF, PRLR
2positive regulation of cerebellar granule cell precursor proliferationGO:00219409.9EGF, IGF1
3positive regulation of DNA bindingGO:00433889.9EGF, IGF1
4branching morphogenesis of an epithelial tubeGO:00487549.8IGF1, EGF
5positive regulation of mitosisGO:00458409.8IGF1, EGF
6positive regulation of acute inflammatory responseGO:00026759.7OSM, IL6
7negative regulation of hormone secretionGO:00468889.7IL6, OSM
8positive regulation of protein import into nucleus, translocationGO:00331609.7IL6, IGF1
9mammary gland alveolus developmentGO:00607499.6ESR1, EGF
10positive regulation of DNA replicationGO:00457409.6IL6, IGF1
11response to heatGO:00094089.5IL6, OSM
12positive regulation of smooth muscle cell proliferationGO:00486619.5IGF1, IL6
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGO:00605279.5ESR1, IGF1
14positive regulation of peptidyl-serine phosphorylationGO:00331389.4IL6, OSM
15positive regulation of osteoblast differentiationGO:00456699.3IGF1, IL6
16positive regulation of nitric oxide biosynthetic processGO:00454299.3IL6, ESR1
17positive regulation of fibroblast proliferationGO:00481469.3ESR1, IGF1
18negative regulation of gene expressionGO:00106299.3ESR1, PGR
19positive regulation of epithelial cell proliferationGO:00506799.2IL6, IGF1
20platelet activationGO:00301689.2EGF, IL6, IGF1
21positive regulation of MAPK cascadeGO:00434109.2IGF1, OSM, IL6
22positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.2IL6, OSM, IGF1
23positive regulation of protein kinase B signalingGO:00518979.0IL6, IGF1
24negative regulation of cell proliferationGO:00082858.9IL6, OSM, IGF1
25signal transductionGO:00071658.6IGF1, PGR, ESR1, EGF
26positive regulation of cell proliferationGO:00082848.3EGF, IL6, LIFR, OSM, IGF1
27positive regulation of transcription from RNA polymerase II promoterGO:00459448.3IGF1, OSM, ESR1, IL6

Molecular functions related to Cerebral Meningioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:00037079.3ESR1, PGR
2steroid bindingGO:00054969.2ESR1, PGR
3growth factor activityGO:00080838.4EGF, IL6, OSM, IGF1
4protein bindingGO:00055156.8IGF1, PGR, ESR1, PRLR, IL6, DRD1

Products for genes affiliated with Cerebral Meningioma

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Sources for Cerebral Meningioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet