MCID: CRB036
MIFTS: 44

Cerebral Meningioma malady

Summaries for Cerebral Meningioma

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32MalaCards
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MalaCards: Cerebral Meningioma, also known as meningioma of cerebrum, is related to meningioma and anorexia nervosa. An important gene associated with Cerebral Meningioma is DRD1 (dopamine receptor D1), and among its related pathways are CREB Pathway and Ovarian Infertility Genes. The compounds gnrh and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and thyroid, and related mouse phenotypes are nervous system and endocrine/exocrine gland.

Aliases & Classifications for Cerebral Meningioma

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

cerebral meningioma 8 44 60
meningioma of cerebrum 8


External Ids:

Disease Ontology8 DOID:6112
SNOMED-CT56 189164002
NCIt39 C4807

Related Diseases for Cerebral Meningioma

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17GeneCards, 18GeneDecks
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Diseases related to Cerebral Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma30.9PGR, ESR1
2anorexia nervosa29.9IGF1
3adenoma29.9OSM, PRLR, LIFR, IGF1
4leukemia29.9OSM, EGF, PRLR, LIFR, IL6
5cerebritis10.6
6alcohol dependence10.0DRD1
7leiomyosarcoma10.0PGR
8migraine10.0DRD1
9obsessive-compulsive disorder10.0DRD1
10schizophrenia10.0DRD1
11essential hypertension10.0DRD1
12gastric ulcer10.0EGF
13peritonitis10.0IL6
14sarcoma10.0OSM
15thyroid cancer10.0EGF
16kaposi's sarcoma10.0IL6
17sertoli-leydig cell tumor10.0PGR
18insulinoma10.0PRLR
19meningitis10.0IL6
20arthropathy10.0OSM
21hypertension10.0IGF1
22eye disease10.0IL6
23melanoma10.0OSM
24retinopathy of prematurity10.0IGF1
25lung cancer10.0IGF1
26polycystic ovary syndrome10.0IGF1
27periodontal disease10.0IL6
28inflammatory bowel disease10.0IL6
29pancreatitis10.0IL6
30hepatocellular carcinoma10.0PRLR, IL6
31prion disease10.0IL6
32diabetic retinopathy10.0IGF1
33hyperprolactinemia10.0PRLR, IGF1
34ovarian disease10.0ESR1
35asthma10.0LIFR, OSM
36acromegaly10.0PRLR, IGF1
37short bowel syndrome10.0EGF
38donohue syndrome10.0IGF1, EGF
39obesity10.0IGF1, IL6
40uterine fibroid10.0ESR1, PGR
41insulin resistance10.0IL6, IGF1
42arthritis10.0IL6, OSM
43progesterone resistance10.0PGR, ESR1
44cribriform carcinoma10.0PGR, ESR1
45angiomyolipoma10.0ESR1, PGR
46cervical adenocarcinoma10.0PGR, ESR1
47mammary paget's disease10.0PGR, ESR1
48malignant mixed mullerian tumor10.0ESR1, PGR
49male breast cancer10.0ESR1, PGR
50adenosarcoma10.0PGR, ESR1

Graphical network of the top 20 diseases related to Cerebral Meningioma:



Diseases related to cerebral meningioma

Clinical Features for Cerebral Meningioma

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Drugs & Therapeutics for Cerebral Meningioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebral Meningioma

Drug clinical trials:

Search ClinicalTrials for Cerebral Meningioma

Search NIH Clinical Center for Cerebral Meningioma

Search CenterWatch for Cerebral Meningioma

Genetic Tests for Cerebral Meningioma

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Anatomical Context for Cerebral Meningioma

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32MalaCards
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MalaCards organs/tissues related to Cerebral Meningioma:

32
Brain, Skin, Thyroid, Endothelial

Animal Models for Cerebral Meningioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cerebral Meningioma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.9DRD1, PRLR
2MP:00053799.1PRLR, IL6, EGF
3MP:00053698.9IGF1, DRD1, ESR1
4MP:00107718.7DRD1, IL6, PRLR, OSM
5MP:00020068.6IL6, PGR, IGF1, PRLR
6MP:00053908.2IL6, IGF1, LIFR, PRLR, PGR
7MP:00053757.8ESR1, IGF1, IL6, PRLR
8MP:00053867.5ESR1, PGR, PRLR, OSM, DRD1, IL6
9MP:00053877.2EGF, DRD1, ESR1, LIFR, IGF1, PGR
10MP:00053787.0IL6, IGF1, LIFR, PRLR, EGF, DRD1
11MP:00053767.0DRD1, PRLR, LIFR, IGF1, IL6, ESR1

Publications for Cerebral Meningioma

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50PubMed
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Articles related to Cerebral Meningioma:

(show all 39)
idTitleAuthorsYear
1
Cerebral meningioma presenting as dystonic head tremor. (24259285)
2014
2
A rare cause of stroke in young adults: occlusion of the middle cerebral artery by a meningioma postpartum. (24198989)
2013
3
Distant cerebral venous sinus thrombosis in meningioma surgery: a rare complication. (23644326)
2013
4
Erratum: CASE REPORT: MENINGIOMA WITH INTRA-TUMOURAL HAEMORRHAGE SECONDARY TO RUPTURED DISTAL ANTERIOR CEREBRAL ARTERY ANEURYSM. (24396519)
2013
5
Case Report: Meningioma with Intra-tumoural Haemorrhage Secondary to Ruptured Distal Anterior Cerebral Artery Aneurysm. (24179557)
2013
6
Unexpected finding of cerebral meningioma on (11)C-PiB PET. (23429388)
2013
7
An incidental finding of cerebral meningioma on 99mTc-TRODAT-1 dopamine transporter SPECT/CT. (22889784)
2012
8
Unexpected finding on I-123 FP-CIT SPECT leading to the diagnosis of cerebral meningioma. (21220989)
2011
9
Meningioma manifesting as cerebral infarction. (20671387)
2010
10
Severe brain edema caused by a meningioma obstructing cerebral venous outflow and treated with venous sinus stenting. Case report. (18240938)
2008
11
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
12
Contiguous synchronous occurrence of primary cerebral lymphoma and meningioma. (17453773)
2007
13
An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. (16724700)
2006
14
Malignant lymphoma arising in the cerebral parenchyma adjacent to a parasagittal meningioma. (16936461)
2006
15
Acute haemorrhage into a microcystic meningioma leading to cerebral herniation. (16455530)
2005
16
Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma. (16293883)
2005
17
Radiotherapy after surgery for benign cerebral meningioma. (15066300)
2004
18
Can the calcitonin used for a shoulder-hand syndrome have a role in the revelation of a cerebral meningioma? (15589451)
2004
19
Estrogen and progesterone receptors in cerebral meningioma and their clinical value]. (12378940)
2002
20
Radiation-induced skin ulcer, cerebral meningioma, and skin cancer following radiation and radium treatment for actinomycosis. (11994636)
2002
21
"Anorexia saved my life": coincidental anorexia nervosa and cerebral meningioma. (11746295)
2001
22
Post-operative computed tomography in two dogs with cerebral meningioma. (11052366)
2000
23
Psammomatous cerebral intraventricular meningioma in a bull. (10812409)
1999
24
Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. (9488310)
1998
25
Cerebral edema associated with meningiomas: the role of peritumoral brain tissue. (9524107)
1998
26
Effect of LINAC radiosurgery on regional cerebral blood flow, glucose metabolism and sodium-potassium AtPase in skull base meningiomas and metastasis. (9233427)
1997
27
Correlation of vascular endothelial growth factor messenger RNA expression with peritumoral vasogenic cerebral edema in meningiomas. (8929501)
1996
28
Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. (7897522)
1995
29
Combined occurrence of primary cerebral lymphoma and meningioma. (7566529)
1995
30
Results of craniotomy for the treatment of cerebral meningioma in 42 cats. (8191679)
1994
31
Presence of dopamine D1 receptors and absence of dopamine D2 receptors in human cerebral meningioma tissue. (1385626)
1992
32
Association of primary cerebral lymphoma with meningioma: report of two cases. (2187641)
1990
33
Hormonal dependency of cerebral meningiomas. Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas. (2213165)
1990
34
Hormonal dependency of cerebral meningiomas. Part 1: Female sex steroid receptors and their significance as specific markers for adjuvant medical therapy. (2213164)
1990
35
Radiation-induced cerebral meningioma: a recognizable entity. (6593438)
1984
36
Meningioma presenting as recurrent transient cerebral ischemia. (6670605)
1983
37
Meningioma presenting as recurrent transient cerebral ischemia and intracranial hemorrhage. (7200265)
1982
38
Foot and leg symptoms referrable to bilateral cerebral meningioma--a case report. (14028016)
1962
39
Hemangioendotheliomatous meningioma simulating cerebral arteriosclerosis. (13099462)
1953

Genetic Variations for Cerebral Meningioma

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Expression for genes affiliated with Cerebral Meningioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Meningioma

Search GEO for disease gene expression data for Cerebral Meningioma.

Pathways for genes affiliated with Cerebral Meningioma

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Cerebral Meningioma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0LIFR
29.8PGR, PRLR
3
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9.2LIFR, IL6
4
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9.2LIFR, IL6
58.9IGF1, EGF, ESR1
6
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8.7PRLR, PGR, ESR1, EGF
7
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8.7EGF, IGF1, IL6
88.7IL6, IGF1, EGF
9
Transcription Androgen Receptor nuclear signaling
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8.7IGF1, IL6, EGF
10
Immune response Oncostatin M signaling via JAK-Stat in human cells
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8.7LIFR, OSM, IL6
11
Development Ligand-independent activation of ESR1 and ESR2
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8.6EGF, IGF1, ESR1, DRD1
128.3OSM, PRLR, LIFR, IL6
13
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8.3LIFR, EGF, IL6, IGF1
14
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7.9IL6, IGF1, PRLR, LIFR, EGF
15
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7.9OSM, EGF, PRLR, IL6, LIFR
16
Hide members
7.9DRD1, EGF, IGF1, PGR, ESR1, PRLR
177.8IGF1, PRLR, EGF, OSM, IL6
187.8OSM, IL6, IGF1, LIFR, PRLR
19
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7.7IL6, IGF1, LIFR, EGF, OSM
20
Hide members
7.7OSM, EGF, IL6, IGF1, LIFR
21
Hide members
7.6LIFR, ESR1, IL6, IGF1, EGF
22
Hide members
7.1EGF, ESR1, IL6, LIFR, IGF1, OSM

Compounds for genes affiliated with Cerebral Meningioma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cerebral Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1gnrh4410.2PRLR, PGR
2estrogen4410.1DRD1, LIFR
3bromocriptine28 44 1112.1PRLR, DRD1
4dihydrotestosterone44 28 11 2412.9ESR1, PGR
5Ethynodiol Diacetate119.9PGR, ESR1
6ici 164384449.9ESR1, PGR
7Allylestrenol119.9ESR1, PGR
8Etonogestrel119.9PGR, ESR1
9idoxifene449.8ESR1, PGR
10cmdb7449.8IGF1, EGF
11triphenylethylene449.8PGR, ESR1
12fluoxymesterone44 1110.7PRLR, ESR1
13tamoxifen44 49 28 1112.7PGR, IGF1, PRLR
14norgestimate44 1110.6PGR, ESR1
15dichlorodiphenyltrichloroethane449.5ESR1, OSM
16lapatinib44 49 1111.5PGR, ESR1, EGF
17fulvestrant44 49 28 1112.5ESR1, PGR, EGF
18progestins449.5ESR1, PGR, PRLR
19droloxifene449.4ESR1, PGR, IGF1
20nandrolone44 2410.4IGF1, PGR, ESR1
21leuprolide acetate449.4IGF1, ESR1, PGR
22clomiphene citrate449.4PGR, ESR1, IGF1
23trastuzumab44 49 1111.4ESR1, PGR, EGF
24letrozole44 49 59 1112.4PGR, ESR1, IGF1
25estradiol44 11 2411.4PGR, DRD1, OSM, PRLR
26estrone sulfate44 2410.4ESR1, IGF1, PGR
27raloxifene44 28 49 1112.3IGF1, ESR1, PGR
28dexamethasone44 49 28 1112.2OSM, IL6, PRLR
294-hydroxytamoxifen449.0EGF, IGF1, PGR, ESR1
30geldanamycin44 49 59 1112.0ESR1, PGR, EGF
31paclitaxel44 49 1110.9LIFR, PGR, EGF, ESR1
32mifepristone44 59 28 1111.8ESR1, PGR, EGF
33gp 130448.7LIFR, OSM, IL6
34indomethacin44 59 28 1111.7EGF, OSM, PGR, IL6
35progestin448.6IGF1, PRLR, PGR, ESR1, EGF
36megestrol acetate448.6PGR, IL6, ESR1, IGF1
37phosphatidylinositol448.5EGF, DRD1, OSM, IGF1, PRLR
38steroid448.5ESR1, LIFR, PRLR, EGF, OSM
39acth448.5IL6, OSM, IGF1, LIFR
40pd 98,059448.4IGF1, IL6, EGF, OSM
41ly294002448.2IL6, EGF, ESR1, IGF1
42thymidine44 249.2OSM, IL6, PRLR, IGF1, EGF
43progesterone44 59 28 11 2412.2EGF, PRLR, LIFR, IGF1, ESR1, PGR
44alanine448.1PRLR, IL6, OSM, LIFR, PGR
45actinomycin d448.1IL6, IGF1, EGF, ESR1
46testosterone44 59 11 2410.8PRLR, IGF1, IL6, ESR1, EGF, PGR
47vegf447.6OSM, IGF1, EGF, PGR, IL6, ESR1
48retinoic acid44 248.6IGF1, PGR, IL6, ESR1, EGF, OSM
49tyrosine447.4LIFR, PRLR, OSM, IL6, IGF1, DRD1
50genistein44 28 59 2 11 2412.0PRLR, ESR1, IL6, PGR, IGF1, EGF

GO Terms for genes affiliated with Cerebral Meningioma

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16Gene Ontology
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Cellular components related to Cerebral Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9IL6, IGF1, LIFR, PRLR, EGF

Biological processes related to Cerebral Meningioma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1activation of transmembrane receptor protein tyrosine kinase activityGO:0071719.9PRLR, EGF
2positive regulation of cerebellar granule cell precursor proliferationGO:0219409.8IGF1, EGF
3positive regulation of DNA bindingGO:0433889.7EGF, IGF1
4mammary gland alveolus developmentGO:0607499.6EGF, ESR1
5branching morphogenesis of an epithelial tubeGO:0487549.6EGF, IGF1
6prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGO:0605279.6IGF1, ESR1
7positive regulation of mitosisGO:0458409.5EGF, IGF1
8positive regulation of acute inflammatory responseGO:0026759.4IL6, OSM
9negative regulation of hormone secretionGO:0468889.4OSM, IL6
10positive regulation of protein import into nucleus, translocationGO:0331609.3IGF1, IL6
11positive regulation of DNA replicationGO:0457409.1IGF1, IL6
12positive regulation of MAPK cascadeGO:0434108.9IGF1, OSM, IL6
13positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.9OSM, IGF1, IL6
14platelet activationGO:0301688.8IL6, IGF1, EGF
15positive regulation of nitric oxide biosynthetic processGO:0454298.7IL6, ESR1
16positive regulation of cell proliferationGO:0082848.1IGF1, OSM, EGF, IL6, LIFR
17positive regulation of transcription from RNA polymerase II promoterGO:0459447.9OSM, IGF1, IL6, ESR1

Molecular functions related to Cerebral Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.5ESR1, PGR
2growth factor activityGO:0080837.9IL6, IGF1, EGF, OSM

Products for genes affiliated with Cerebral Meningioma

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  • Antibodies
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Sources for Cerebral Meningioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet