MCID: CRB036
MIFTS: 36

Cerebral Meningioma malady

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebral Meningioma

Aliases & Descriptions for Cerebral Meningioma:

Name: Cerebral Meningioma 12 52 14 69
Meningioma of Cerebrum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6112
NCIt 47 C4807
SNOMED-CT 64 189164002
UMLS 69 C0542564

Summaries for Cerebral Meningioma

MalaCards based summary : Cerebral Meningioma, also known as meningioma of cerebrum, is related to cerebritis and adenoma, and has symptoms including headache and seizures. An important gene associated with Cerebral Meningioma is DRD1 (Dopamine Receptor D1), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Coagulants and Hemostatics have been mentioned in the context of this disorder. Affiliated tissues include skin and thyroid, and related phenotypes are adipose tissue and growth/size/body region

Related Diseases for Cerebral Meningioma

Diseases related to Cerebral Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 cerebritis 10.2
2 adenoma 9.7
3 thyroiditis 9.7
4 parathyroid adenoma 9.7
5 anorexia nervosa 9.5
6 keratopathy 9.5
7 leukemia 9.5
8 papillary carcinoma 9.5
9 actinomycosis 9.5
10 tremor 9.5
11 anal canal carcinoma 9.2 DRD1 EGF IL6R LIFR PRLR

Graphical network of the top 20 diseases related to Cerebral Meningioma:



Diseases related to Cerebral Meningioma

Symptoms & Phenotypes for Cerebral Meningioma

UMLS symptoms related to Cerebral Meningioma:


headache, seizures

MGI Mouse Phenotypes related to Cerebral Meningioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.13 DRD1 IL6R PRLR
2 growth/size/body region MP:0005378 9.02 DRD1 EGF IL6R LIFR PRLR

Drugs & Therapeutics for Cerebral Meningioma

Drugs for Cerebral Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 220)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Coagulants Phase 4,Phase 3
2 Hemostatics Phase 4,Phase 3
3 Thrombin Phase 4
4 Fibrin Tissue Adhesive Phase 4
5
Tranexamic Acid Approved Phase 3 1197-18-8 5526
6
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
7
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
10
Ondansetron Approved Phase 3 99614-02-5 4595
11
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
12
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
13
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
14
Cyproheptadine Approved Phase 3 129-03-3 2913
15
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
16 Dermatologic Agents Phase 3,Phase 2,Phase 1
17 Antifibrinolytic Agents Phase 3
18 Liver Extracts Phase 3,Phase 1,Phase 2
19 pancreatic polypeptide Phase 3,Phase 1
20 Analgesics Phase 3,Phase 2,Phase 1
21 Cholinergic Agents Phase 3,Phase 2
22 Adjuvants, Anesthesia Phase 3
23 Cholinesterase Inhibitors Phase 3,Phase 2
24 Narcotics Phase 3
25 Gastrointestinal Agents Phase 3,Phase 1
26 Neurotransmitter Agents Phase 3,Phase 2,Phase 1
27 Nootropic Agents Phase 3,Phase 2
28 Analgesics, Opioid Phase 3
29 Anesthetics Phase 3
30 Anesthetics, General Phase 3
31 Anesthetics, Intravenous Phase 3
32 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
33 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
34 Central Nervous System Stimulants Phase 3,Phase 2
35 Dexamethasone acetate Phase 3,Phase 1 1177-87-3
36 Dexamethasone 21-phosphate Phase 3,Phase 1
37 Emetics Phase 3
38 Antiemetics Phase 3,Phase 1
39 BB 1101 Phase 3,Phase 1
40 Autonomic Agents Phase 3,Phase 1
41
Histamine Phosphate Phase 3 51-74-1 65513
42
Serotonin Phase 3 50-67-9 5202
43 Serotonin Agents Phase 3
44 Serotonin Antagonists Phase 3
45 Neurotransmitter Uptake Inhibitors Phase 3
46 Histamine Antagonists Phase 3
47 Histamine H1 Antagonists Phase 3
48 Dexmethylphenidate Hydrochloride Phase 3
49 Dopamine Agents Phase 3
50 Dopamine Uptake Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 139)
id Name Status NCT ID Phase
1 Phase IV Bioseal Study in Brain Tumor Surgery Completed NCT02034799 Phase 4
2 Efficacy of Tranexamic Acid in Brain Tumor Resections Unknown status NCT01655927 Phase 3
3 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
4 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3
5 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
6 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Active, not recruiting NCT01346267 Phase 3
7 Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery Terminated NCT00104936 Phase 3
8 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3
9 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
10 Hydroxyurea in Treating Patients With Recurrent and/or Unresectable Meningioma Unknown status NCT00006119 Phase 2
11 Hydroxyurea With or Without Imatinib Mesylate in Treating Patients With Recurrent or Progressive Meningioma Unknown status NCT00904735 Phase 2
12 Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma Unknown status NCT00045110 Phase 1, Phase 2
13 Randomized Comparison of Proton and Carbon Ion Radiotherapy With Advanced Photon Radiotherapy in Skull Base Meningiomas: The PINOCCHIO Trial. Unknown status NCT01795300 Phase 1, Phase 2
14 Combination of Hydroxyurea and Verapamil for Refractory Meningiomas Completed NCT00706810 Phase 2
15 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2
16 Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas Completed NCT00002965 Phase 2
17 Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma Completed NCT00010049 Phase 1, Phase 2
18 Radiation Therapy in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Grade II or Grade III Meningioma Completed NCT00626730 Phase 2
19 Vatalanib in Treating Patients With Recurrent or Progressive Meningioma Completed NCT00348790 Phase 2
20 S9811 Hydroxyurea in Treating Patients With Unresectable Benign Meningioma Completed NCT00003590 Phase 2
21 Imatinib Mesylate in Treating Patients With Recurrent Meningioma Completed NCT00045734 Phase 2
22 Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors Completed NCT00025675 Phase 2
23 Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Completed NCT00589784 Phase 2
24 Bevacizumab and Irinotecan for Patients With Primary Brain Tumors and Progression After Standard Therapy Completed NCT00463203 Phase 2
25 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2
26 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2
27 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2
28 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
29 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2
30 SU5416 in Treating Patients With Recurrent Astrocytoma or Mixed Glioma That Has Not Responded to Radiation Therapy Completed NCT00004868 Phase 1, Phase 2
31 Imatinib Mesylate and Hydroxyurea in Treating Patients With Recurrent or Progressive Meningioma Completed NCT00354913 Phase 2
32 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2
33 Monthly SOM230C for Recurrent or Progressive Meningioma Completed NCT00859040 Phase 2
34 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2
35 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2
36 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
37 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2
38 A Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas Recruiting NCT02693990 Phase 1, Phase 2
39 Trabectedin for Recurrent Grade II/III Meningioma Recruiting NCT02234050 Phase 2
40 Enhancement of Neurocognitive Functions by Hippocampal Sparing Radiotherapy Recruiting NCT01849484 Phase 2
41 Proton Radiation For Meningiomas and Hemangiopericytomas Recruiting NCT01117844 Phase 1, Phase 2
42 Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma Recruiting NCT02847559 Phase 2
43 Vismodegib and FAK Inhibitor GSK2256098 in Treating Patients With Progressive Meningiomas Recruiting NCT02523014 Phase 2
44 Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas Recruiting NCT01966809 Phase 2
45 Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma Active, not recruiting NCT00895622 Phase 2
46 Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
47 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Active, not recruiting NCT01024907 Phase 1, Phase 2
48 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2
49 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
50 Proton Dose Escalation for Patients With Atypical or Anaplastic Meningiomas Not yet recruiting NCT02978677 Phase 2

Search NIH Clinical Center for Cerebral Meningioma

Genetic Tests for Cerebral Meningioma

Anatomical Context for Cerebral Meningioma

MalaCards organs/tissues related to Cerebral Meningioma:

39
Skin, Thyroid

Publications for Cerebral Meningioma

Articles related to Cerebral Meningioma:

(show all 22)
id Title Authors Year
1
Uncommon association of cerebral meningioma, parathyroid adenoma and papillary thyroid carcinoma in a patient harbouring a rare germline variant in the CDKN1B gene. ( 26762354 )
2016
2
Cognitive and emotional problems in patients after cerebral meningioma surgery. ( 24763925 )
2014
3
Cerebral meningioma presenting as dystonic head tremor. ( 24259285 )
2014
4
Unexpected finding of cerebral meningioma on (11)C-PiB PET. ( 23429388 )
2013
5
An incidental finding of cerebral meningioma on 99mTc-TRODAT-1 dopamine transporter SPECT/CT. ( 22889784 )
2012
6
Unexpected finding on I-123 FP-CIT SPECT leading to the diagnosis of cerebral meningioma. ( 21220989 )
2011
7
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. ( 17894293 )
2007
8
An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. ( 16724700 )
2006
9
Radiotherapy after surgery for benign cerebral meningioma. ( 15066300 )
2004
10
Can the calcitonin used for a shoulder-hand syndrome have a role in the revelation of a cerebral meningioma? ( 15589451 )
2004
11
[Estrogen and progesterone receptors in cerebral meningioma and their clinical value]. ( 12378940 )
2002
12
Radiation-induced skin ulcer, cerebral meningioma, and skin cancer following radiation and radium treatment for actinomycosis. ( 11994636 )
2002
13
"Anorexia saved my life": coincidental anorexia nervosa and cerebral meningioma. ( 11746295 )
2001
14
Post-operative computed tomography in two dogs with cerebral meningioma. ( 11052366 )
2000
15
Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. ( 9488310 )
1998
16
Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. ( 7897522 )
1995
17
Results of craniotomy for the treatment of cerebral meningioma in 42 cats. ( 8191679 )
1994
18
Presence of dopamine D1 receptors and absence of dopamine D2 receptors in human cerebral meningioma tissue. ( 1385626 )
1992
19
Hormonal dependency of cerebral meningiomas. Part 1: Female sex steroid receptors and their significance as specific markers for adjuvant medical therapy. ( 2213164 )
1990
20
Hormonal dependency of cerebral meningiomas. Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas. ( 2213165 )
1990
21
Radiation-induced cerebral meningioma: a recognizable entity. ( 6593438 )
1984
22
Foot and leg symptoms referrable to bilateral cerebral meningioma--a case report. ( 14028016 )
1962

Variations for Cerebral Meningioma

Expression for Cerebral Meningioma

Search GEO for disease gene expression data for Cerebral Meningioma.

Pathways for Cerebral Meningioma

Pathways related to Cerebral Meningioma according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 EGF IL6R LIFR PRLR
2
Show member pathways
12.99 EGF IL6R LIFR PRLR
3
Show member pathways
12.67 EGF IL6R LIFR PRLR
4 11.77 EGF IL6R
5
Show member pathways
11.7 EGF IL6R
6 11.67 EGF IL6R PRLR
7 11.64 LIFR PRLR
8
Show member pathways
11.53 EGF PRLR
9 11.47 EGF IL6R
10 11.38 EGF IL6R
11 11.23 EGF IL6R
12
Show member pathways
11.13 IL6R LIFR
13
Show member pathways
11.04 IL6R LIFR PRLR
14 11.02 EGF PRLR
15 10.84 EGF IL6R

GO Terms for Cerebral Meningioma

Cellular components related to Cerebral Meningioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.46 EGF IL6R LIFR PRLR
2 plasma membrane GO:0005886 9.35 DRD1 EGF IL6R LIFR PRLR
3 receptor complex GO:0043235 8.62 EGF LIFR

Biological processes related to Cerebral Meningioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.5 EGF IL6R LIFR
2 cytokine-mediated signaling pathway GO:0019221 9.4 IL6R LIFR
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.37 EGF IL6R
4 response to cytokine GO:0034097 9.26 IL6R LIFR
5 mammary gland alveolus development GO:0060749 9.16 EGF PRLR
6 activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 8.96 EGF PRLR
7 ciliary neurotrophic factor-mediated signaling pathway GO:0070120 8.62 IL6R LIFR

Molecular functions related to Cerebral Meningioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ciliary neurotrophic factor receptor activity GO:0004897 8.62 IL6R LIFR

Sources for Cerebral Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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