MCID: CRB037
MIFTS: 64

Cerebral Palsy malady

Neuronal diseases category

Summaries for Cerebral Palsy

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cerebral palsy is a group of disorders that affect a person's ability to move and to maintain balance and posture. the disorders appear in the first few years of life. usually they do not get worse over time. people with cerebral palsy may have difficulty walking. they may also have trouble with tasks such as writing or using scissors. some have other medical conditions, including seizure disorders or mental impairment. cerebral palsy happens when the areas of the brain that control movement and posture do not develop correctly or get damaged. early signs of cerebral palsy usually appear before 3 years of age. babies with cerebral palsy are often slow to roll over, sit, crawl, smile, or walk. some babies are born with cerebral palsy; others get it after they are born. there is no cure for cerebral palsy, but treatment can improve the lives of those who have it. treatment includes medicines, braces, and physical, occupational and speech therapy. nih: national institute of neurological disorders and stroke

MalaCards: Cerebral Palsy, also known as infantile cerebral palsy, is related to ataxic cerebral palsy and spastic quadriplegia. An important gene associated with Cerebral Palsy is KANK1 (KN motif and ankyrin repeat domains 1), and among its related pathways are Lysosome and Allograft rejection. The drugs baclofen and dantrolene and the compounds alanine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

NINDS:43 The term cerebral palsy refers to any one of a number of neurological disorders that appear in infancy or early childhood and permanently affect body movement and muscle coordination but don?t worsen over time.

Wikipedia:63 Cerebral palsy (CP) is a general term for a group of permanent, non-progressive movement disorders that... more...

Aliases & Classifications for Cerebral Palsy

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Sources:
42NIH Rare Diseases, 8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

cerebral palsy 8 42 43 10 44 33 30 60
infantile cerebral palsy 8 60
cerebral palsy, mixed 60
mixed cerebral palsy 42
cerebral palsy, nos 8
cerebral palsy nos 8


External Ids:

Disease Ontology8 DOID:1969
NCIt39 C34460
MeSH34 D002547
ICD1025 G80

Related Diseases for Cerebral Palsy

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cerebral Palsy:



Diseases related to cerebral palsy

Clinical Features for Cerebral Palsy

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Drugs & Therapeutics for Cerebral Palsy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebral Palsy

Drug clinical trials:

Search ClinicalTrials for Cerebral Palsy

Search NIH Clinical Center for Cerebral Palsy

Search CenterWatch for Cerebral Palsy

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Cerebral Palsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells for treatment of cerebral palsy
Embryonic/Adult Cultured Cells Related to Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells (family)

Genetic Tests for Cerebral Palsy

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Anatomical Context for Cerebral Palsy

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Cerebral Palsy:

32
Brain, Testes, Bone, Heart, Cortex, Eye, Colon, Dorsal root ganglion, Skeletal muscle, Bone marrow, Spinal cord, Tongue

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Cerebral Palsy:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Cerebral Palsy or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Cerebral Palsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6GAD1, GAD2, NPHS1, AP4E1, DMD, F5
2MP:000363110.5PLP1, UBE3A, AP4E1, AP4B1, NPHS1, GAD2
3MP:000538610.3GAD2, AP4B1, AP4E1, UBE3A, GAD1, DMD

Publications for Cerebral Palsy

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Sources:
50PubMed
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Articles related to Cerebral Palsy:

(show top 50)    (show all 1203)
idTitleAuthorsYear
1
Which functional impairments are the main contributors to pelvic anterior tilt during gait in individuals with cerebral palsy? (24054350)
2014
2
Prevalence of cerebral palsy, co-occurring autism spectrum disorders, and motor functioning - Autism and Developmental Disabilities Monitoring Network, USA, 2008. (24117446)
2014
3
The development of social strengths in children with cerebral palsy. (24383413)
2014
4
Pelizaeus-Merzbacher Disease, Easily Misdiagnosed as Cerebral Palsy: A Report of a Three-generation Family. (23597542)
2013
5
Interlimb coordination during forward walking is largely preserved in backward walking in children with cerebral palsy. (24079947)
2013
6
Observational skills assessment score: reliability in measuring amount and quality of use of the affected hand in unilateral cerebral palsy. (24139170)
2013
7
Subtalar fusion for pes valgus in cerebral palsy: results of a modified technique in the setting of single event multilevel surgery. (23653034)
2013
8
Perspectives of young adults with cerebral palsy on transitioning from pediatric to adult healthcare systems. (23948690)
2013
9
Progressive resistance training and mobility-related function in young people with cerebral palsy: a randomized controlled trial. (23789741)
2013
10
The MM-CGI Cerebral Palsy: modification and pretesting of an instrument to measure anticipatory grief in parents whose child has cerebral palsy. (24131422)
2013
11
A systematic review of interventions for children with cerebral palsy: state of the evidence. (23962350)
2013
12
Assessment of social function in four-year-old children with cerebral palsy. (23477463)
2013
13
Motor learning in children with hemiplegic cerebral palsy and the role of sensation in short-term motor training of goal-directed reaching. (23899048)
2013
14
Executive function in children and adolescents with unilateral cerebral palsy. (23809003)
2013
15
Interactive Rehabilitation System for Improvement of Balance Therapies in People With Cerebral Palsy. (24122561)
2013
16
Outcomes of an exercise program for pain and fatigue management in adults with cerebral palsy. (23924251)
2013
17
Robot-assisted and computer-enhanced therapies for children with cerebral palsy: current state and clinical implementation. (23948688)
2013
18
Nutritional management of children with cerebral palsy: a practical guide. (24301005)
2013
19
Genetic and clinical contributions to cerebral palsy: a multi-variable analysis. (23773706)
2013
20
Aberrant Synchrony in the Somatosensory Cortices Predicts Motor Performance Errors in Children with Cerebral Palsy. (24225536)
2013
21
Quality of life and mental health among parents of children with cerebral palsy: the influence of self-efficacy and coping strategies. (23461414)
2013
22
Assessment of postural control in children with cerebral palsy: a review. (23466474)
2013
23
Passive range of motion in a population-based sample of children with spastic cerebral palsy who walk. (22221005)
2012
24
Twenty weeks of computer-training improves sense of agency in children with spastic cerebral palsy. (22502849)
2012
25
Oral motor performance in spastic cerebral palsy individuals: are hydration and nutritional status associated? (21906174)
2012
26
Relationship between spasticity and health related quality of life in individuals with cerebral palsy. (23175906)
2012
27
Prevalence and risk indicators of temporomandibular disorder signs and symptoms in a pediatric population with spastic cerebral palsy. (21678667)
2011
28
Repair of strabismus and binocular fusion in children with cerebral palsy: gross motor function classification scale. (21873677)
2011
29
Radial extracorporeal shock wave therapy (rESWT) in the treatment of spasticity in cerebral palsy: a randomized, placebo-controlled clinical trial. (22207070)
2011
30
Quality of life in children and adolescents with cerebral palsy and myelomeningocele. (21824563)
2011
31
Multilevel botulinum toxin type a as a treatment for spasticity in children with cerebral palsy: a retrospective study. (20613938)
2010
32
Attentional and executive impairments in children with spastic cerebral palsy. (20002117)
2010
33
Effects of prolonged standing on gait in children with spastic cerebral palsy. (20170432)
2010
34
Inactive lifestyle in adults with bilateral spastic cerebral palsy. (19363572)
2009
35
Long-term efficacy and tolerability of 4-monthly versus yearly botulinum toxin type A treatment for lower-limb spasticity in children with cerebral palsy. (19563586)
2009
36
Parent-proxy ratings of pain before and after botulinum toxin type A treatment for children with spasticity and cerebral palsy. (19454875)
2009
37
Effect of seat surface inclination on postural stability and forward reaching efficiency in children with spastic cerebral palsy. (19647395)
2009
38
Spinal bone mineral density, IGF-1 and IGFBP-3 in children with cerebral palsy. (17912004)
2007
39
Selective dorsal rhizotomy for spastic cerebral palsy: a review. (17551739)
2007
40
Antioxidant enzymes and lipid peroxides in children with cerebral palsy. (15978628)
2005
41
Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy. (15843423)
2005
42
Hip joint subluxation after selective dorsal rhizotomy for spastic cerebral palsy. (16121999)
2005
43
Relationship between vision and motor impairment in children with spastic cerebral palsy: new evidence from electrophysiology. (15129778)
2004
44
Comparison of the energy expenditure index and oxygen consumption index during self-paced walking in children with spastic diplegia cerebral palsy and children without physical disabilities. (17057550)
2004
45
Myocardial hypertrophy of the recipient twins in twin-to-twin transfusion syndrome and cerebral palsy. (12527457)
2003
46
Cerebral blood flow SPECT may be helpful in establishing the diagnosis of progressive supranuclear palsy and corticobasal degeneration. (14600888)
2001
47
A gene for ataxic cerebral palsy maps to chromosome 9p12-q12. (10854109)
2000
48
Antenatal and perinatal antecedents of moderate and severe spastic cerebral palsy. (9890213)
1998
49
Clinical trial of diazepam in adult cerebral palsy. (5317890)
1964
50
Porencephaly and complicated cerebral palsy. (13596005)
1958

Genetic Variations for Cerebral Palsy

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Expression for genes affiliated with Cerebral Palsy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Palsy

Search GEO for disease gene expression data for Cerebral Palsy.

Pathways for genes affiliated with Cerebral Palsy

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Sources:
29KEGG, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Cerebral Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5AP4E1, AP4M1, AP4S1, AP4B1
2
Hide members
10.5IL9, DMD, GAD1, GAD2
310.5GAD2, GAD1
4
Hide members
10.5GAD1, GAD2
5
Hide members
10.5GAD1, GAD2
610.5GAD1, GAD2
710.5GAD1, GAD2
810.5GAD1, GAD2

Compounds for genes affiliated with Cerebral Palsy

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Cerebral Palsy according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1alanine4410.9UBE3A, GAD2, GAD1, DMD, F5, MNX1
2nitric oxide44 11 2412.9SIRPA, GAD2, GAD1, DMD, F5, IL9
3cysteine4410.9UBE3A, GAD2, GAD1, DMD, F5, MMP8
4oligonucleotide4410.9GAD2, GAD1, DMD, IL9, MMP8, PLP1
5tyrosine4410.9UBE3A, NPHS1, GAD2, GAD1, DMD, TOR1A
6proline4410.9GAD2, GAD1, DMD, F5, MMP8
7gaba4410.8PLP1, GAD1, GAD2, UBE3A
8cysteine sulfinic acid4410.8GAD2, GAD1
9retinoic acid44 2411.8NPHS1, F5, MNX1, IL9, MMP8, PLP1
10hypotaurine59 44 2412.8GAD1, GAD2
113-Sulfinoalanine11 2411.8GAD1, GAD2
12glucose4410.8NPHS1, GAD2, GAD1, DMD, MMP8, SIRPA
13acetylcholine44 49 28 11 2414.8PLP1, DMD, GAD1, GAD2
14calcium44 49 11 2413.8NPHS1, GAD2, GAD1, DMD, F5, MMP8
15ornithine44 2411.8GAD2, GAD1, DMD
16cacl24410.7MMP8, F5
17pyridoxal44 11 2412.7GAD1, GAD2
18urea44 11 2412.7DMD, F5, MMP8
19gold4410.7DMD, GAD1, UBE3A
20hind iii4410.6F5, DMD
21bromodeoxyuridine4410.6GAD1, DMD, IL9
22arginine4410.6PLP1, F5, DMD, GAD1, NPHS1
23cyclosporin a44 28 5912.5MMP8, DMD, GAD1, GAD2
24lipid4410.5NPHS1, DMD, IL9, MMP8, SIRPA, PLP1
25L-Aspartic Acid11 2411.4GAD2, GAD1
26benzodiazepine4410.2UBE3A, GAD1

GO Terms for genes affiliated with Cerebral Palsy

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16Gene Ontology
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Cellular components related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin adaptor complexGO:03013110.5AP4B1, AP4M1
2clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.2GAD1, GAD2

Biological processes related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vesicle-mediated transportGO:01619210.5AP4B1, AP4M1, AP4E1
2glutamate decarboxylation to succinateGO:00654010.4GAD1, GAD2
3neurotransmitter biosynthetic processGO:04213610.2GAD1, GAD2

Molecular functions related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin bindingGO:01702210.5DMD, NPHS1
2glutamate decarboxylase activityGO:00435110.4GAD1, GAD2
3glutamate bindingGO:01659510.2GAD1, GAD2

Products for genes affiliated with Cerebral Palsy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet