MCID: CRB037
MIFTS: 65

Cerebral Palsy malady

Rare diseases, Neuronal diseases categories
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Summaries for Cerebral Palsy

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MedlinePlus:33 Cerebral palsy is a group of disorders that affect a person's ability to move and to maintain balance and posture. the disorders appear in the first few years of life. usually they do not get worse over time. people with cerebral palsy may have difficulty walking. they may also have trouble with tasks such as writing or using scissors. some have other medical conditions, including seizure disorders or mental impairment. cerebral palsy happens when the areas of the brain that control movement and posture do not develop correctly or get damaged. early signs of cerebral palsy usually appear before 3 years of age. babies with cerebral palsy are often slow to roll over, sit, crawl, smile, or walk. some babies are born with cerebral palsy; others get it after they are born. there is no cure for cerebral palsy, but treatment can improve the lives of those who have it. treatment includes medicines, braces, and physical, occupational and speech therapy. nih: national institute of neurological disorders and stroke

MalaCards based summary: Cerebral Palsy, also known as infantile cerebral palsy, is related to stiff-person syndrome and cerebritis. An important gene associated with Cerebral Palsy is KANK1 (KN motif and ankyrin repeat domains 1), and among its related pathways are Lysosome and Cytokine Network. The drugs baclofen and dantrolene and the compounds alendronate and cacl2 have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are digestive/alimentary and behavior/neurological.

Disease Ontology:8 A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

NINDS:43 The term cerebral palsy refers to any one of a number of neurological disorders that appear in infancy or early childhood and permanently affect body movement and muscle coordination but don?t worsen over time.

Wikipedia:65 Cerebral palsy (CP) is a general term for a group of permanent movement problems that do not get worse... more...

Aliases & Classifications for Cerebral Palsy

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Cerebral Palsy, Aliases & Descriptions:

Name: Cerebral Palsy 30 8 42 43 10 44 33 62
Infantile Cerebral Palsy 8 62
 
Cerebral Palsy, Mixed 62
Mixed Cerebral Palsy 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:1969
MeSH34 D002547
NCIt39 C34460
ICD1025 G80

Related Diseases for Cerebral Palsy

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Graphical network of the top 20 diseases related to Cerebral Palsy:



Diseases related to cerebral palsy

Symptoms for Cerebral Palsy

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Drugs & Therapeutics for Cerebral Palsy

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Drug clinical trials:

Search ClinicalTrials for Cerebral Palsy

Search NIH Clinical Center for Cerebral Palsy

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Cerebral Palsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells for treatment of cerebral palsy
Embryonic/Adult Cultured Cells Related to Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells (family)

Genetic Tests for Cerebral Palsy

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Anatomical Context for Cerebral Palsy

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MalaCards organs/tissues related to Cerebral Palsy:

32
Brain, Testes, Bone, Eye, Heart, Cortex, Colon, Bone marrow, Spinal cord, Skeletal muscle, Dorsal root ganglion, Tongue

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Cerebral Palsy:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Cerebral Palsy or affiliated genes

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MGI Mouse Phenotypes related to Cerebral Palsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3GAD2, GAD1, IL9, IL18
2MP:00053867.0GAD2, AP4E1, AP4B1, TOR1A, IL18, F5
3MP:00036316.9AP4E1, AP4B1, TOR1A, IL18, F5, GAD1
4MP:00053766.5AP4E1, TOR1A, IL18, IL9, F5, GAD1

Publications for Cerebral Palsy

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Articles related to Cerebral Palsy:

(show top 50)    (show all 1214)
idTitleAuthorsYear
1
Can a lifestyle intervention improve physical fitness in adolescents and young adults with spastic cerebral palsy? A randomized controlled trial. (25067790)
2014
2
Clinical features of cerebral palsy in children with symptomatic congenital cytomegalovirus infection. (24931914)
2014
3
Surgical intervention for feeding and nutrition difficulties in cerebral palsy: a systematic review. (23738903)
2014
4
Tendon structure and extracellular matrix components are affected by spasticity in cerebral palsy patients. (23885344)
2013
5
Sensory feedback to ankle plantar flexors is not exaggerated during gait in spastic children with cerebral palsy. (24225545)
2013
6
Life care planning for the child with cerebral palsy. (23910487)
2013
7
A systematic review of activities of daily living measures for children and adolescents with cerebral palsy. (23937056)
2013
8
Pelizaeus-Merzbacher Disease, Easily Misdiagnosed as Cerebral Palsy: A Report of a Three-generation Family. (23597542)
2013
9
Reliability of Fractional Anisotropy Measurement for Children with Cerebral Palsy. (24122275)
2013
10
Geographical patterns in the recreation and leisure participation of children and youth with cerebral palsy: a CAPE international collaborative network study. (23477429)
2013
11
Atrophy and hypertrophy following injections of botulinum toxin in children with cerebral palsy. (23859067)
2013
12
Botulinum Toxin Treatment on Upper Limb Function in School Age Children With Bilateral Spastic Cerebral Palsy: One Year Follow-up. (23869330)
2013
13
Early prediction of cerebral palsy after neonatal intensive care using motor development trajectories in infancy. (23856349)
2013
14
Interlimb coordination during forward walking is largely preserved in backward walking in children with cerebral palsy. (24079947)
2013
15
Outcomes of rectus femoris transfers in children with cerebral palsy: effect of transfer site. (23482268)
2013
16
A comparison study of depression and quality of life in Turkish mothers of children with Down syndrome, cerebral palsy, and autism spectrum disorder. (23654042)
2013
17
Speech and language development in 2-year-old children with cerebral palsy. (23627373)
2013
18
Rotational osteotomy with submuscular plating in skeletally immature patients with cerebral palsy. (23579357)
2013
19
Selective dorsal rhizotomy for spasticity not associated with cerebral palsy: reconsideration of surgical inclusion criteria. (24175866)
2013
20
Predictors for changes in various developmental outcomes of children with cerebral palsy--a longitudinal study. (24025438)
2013
21
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial. (24112817)
2013
22
A comparison of treadmill training and overground walking in ambulant children with cerebral palsy: randomized controlled clinical trial. (23503736)
2013
23
Effects of a recreational ice skating program on the functional mobility of a child with cerebral palsy. (24328904)
2013
24
The relationship between spasticity and muscle volume of the knee extensors in children with cerebral palsy. (22466388)
2012
25
Visual impairment in children with spastic cerebral palsy measured by psychophysical and electrophysiological grating acuity tests. (23030659)
2012
26
Outcomes of correction of internal hip rotation in patients with spastic cerebral palsy using proximal femoral osteotomy. (22425638)
2012
27
A comparison of activity, participation and quality of life in children with and without spastic diplegia cerebral palsy. (22200241)
2012
28
A Comparative Assessment of Motor Function using the Expanded and Revised Gross Motor Function Classification System and the Manual Ability Classification System in the same Children with Cerebral Palsy in Shika, Zaria, Northwestern Nigeria. (23468021)
2012
29
Spinal arteriovenous malformation presenting as spastic monoplegic cerebral palsy in a child. (20546106)
2012
30
Computer-mediated support for adolescents with cerebral palsy or spina bifida. (21099541)
2011
31
Muscle volume and motor development in spastic cerebral palsy. (21574987)
2011
32
Multilevel botulinum toxin type a as a treatment for spasticity in children with cerebral palsy: a retrospective study. (20613938)
2010
33
Surgical management of spasticity in persons with cerebral palsy. (19769917)
2009
34
Mutation in the AP4M1 gene provides a model for neuroaxonal injury in cerebral palsy. (19559397)
2009
35
Motor impairments and activity limitations in children with spastic cerebral palsy: a Dutch population-based study. (19363571)
2009
36
The dependence of spinal cord development on corticospinal input and its significance in understanding and treating spastic cerebral palsy. (17544509)
2007
37
Effects of surgical adductor releases for hip subluxation in cerebral palsy: an AACPDM evidence report. (15344524)
2004
38
The characteristics of sit-to-stand transfer in young children with spastic cerebral palsy based on kinematic and kinetic data. (12535725)
2003
39
Changes in hip spasticity and strength following selective dorsal rhizotomy and physical therapy for spastic cerebral palsy. (11995889)
2002
40
Very high serum creatine kinase level in a child with dyskinetic cerebral palsy. (12142071)
2002
41
Surgery for cerebral palsy part 3: classification and operative procedures for thumb deformity. (11560430)
2001
42
Preterm infants with athetoid cerebral palsy: kernicterus? (11207234)
2001
43
A case of 3-methylglutaconic aciduria misdiagnosed as cerebral palsy. (11118804)
2000
44
Early mobilization after sliding achilles tendon lengthening in children with spastic cerebral palsy. (11139029)
2000
45
Intrathecal baclofen for management of spastic cerebral palsy: multicenter trial. (10695888)
2000
46
Can children with spastic cerebral palsy use self-hypnosis to reduce muscle tone? a preliminary study. (10882882)
2000
47
Stance balance control with orthoses in a group of children with spastic cerebral palsy. (10576639)
1999
48
Cerebral palsy of cystic periventricular leukomalacia in low-birth-weight infants. (8025396)
1994
49
Knee flexion deformity and patella alta in spastic cerebral palsy. (939346)
1976
50
Hip-flexion deformity in spastic cerebral palsy. (5128794)
1971

Variations for Cerebral Palsy

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Expression for genes affiliated with Cerebral Palsy

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Expression patterns in normal tissues for genes affiliated with Cerebral Palsy

Search GEO for disease gene expression data for Cerebral Palsy.

Pathways for genes affiliated with Cerebral Palsy

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Pathways related to Cerebral Palsy according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5AP4E1, AP4B1, AP4S1
29.5IL18, IL9
3
Show member pathways
9.3GAD2, GAD1
4
Show member pathways
phenylethylamine degradation I37
9.3GAD2, GAD1
59.3GAD2, GAD1
6
Show member pathways
9.3GAD2, GAD1
7
Show member pathways
catecholamine biosynthesis37
9.3GAD2, GAD1
8
Show member pathways
9.3GAD2, GAD1
99.3GAD2, GAD1
10
Show member pathways
9.3GAD2, GAD1
11
Show member pathways
9.3GAD2, GAD1
12
Show member pathways
9.3GAD1, GAD2
138.8GAD2, GAD1, TOR1A
14
Show member pathways
8.3GAD2, GAD1, IL9, IL18

Compounds for genes affiliated with Cerebral Palsy

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Compounds related to Cerebral Palsy according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1alendronate44 50 1111.9MMP8, IL18
2cacl2449.8MMP8, F5
3vitamin b6449.8GAD1, F5
4nafamostat mesilate449.8IL18, F5
5tarc449.7IL9, IL18
6Cysteic acid249.7GAD2, GAD1
7cysteine sulfinic acid449.7GAD2, GAD1
8hypotaurine61 44 2411.7GAD2, GAD1
9ciprofloxacin44 50 1111.7IL18, F5
103-Sulfinoalanine24 1110.7GAD2, GAD1
11pyridoxal44 24 1111.7GAD1, GAD2
12L-Aspartic acid24 1110.7GAD2, GAD1
13beta-alanine44 61 28 24 1113.6GAD2, GAD1
14Gamma-Aminobutyric acid249.6GAD2, GAD1
15taurine44 61 2411.6GAD1, GAD2
16mycophenolate mofetil44 50 1111.6F5, IL18
17allergens449.6IL18, IL9
18pyridoxal 5-phosphate449.6GAD2, GAD1
19mptp449.5GAD2, GAD1
20Pyridoxal 5'-phosphate249.5GAD2, GAD1
21c-peptide449.4GAD2, GAD1
22tetrodotoxin44 61 2811.4GAD2, GAD1
23p002449.3MMP8, IL18, F5
24fibrinogen449.2MMP8, IL18, F5
25famotidine44 2 24 1112.2IL18, GAD1, GAD2
26glutamine449.1IL18, F5, GAD1
27acetylcholine44 50 28 24 1113.1GAD2, GAD1, IL18
28progesterone44 28 61 24 1112.9GAD1, F5, IL18, MMP8
29lactate448.9F5, IL18, MMP8
30oligonucleotide448.8MMP8, IL9, GAD1, GAD2
31cyclosporin a44 28 6110.8MMP8, IL18, GAD1, GAD2
32retinoic acid44 249.8MMP8, IL18, IL9, F5
33hydrogen44 249.8GAD2, GAD1, IL18, MMP8
34thymidine44 249.7GAD2, IL9, IL18
35proline448.7GAD2, GAD1, F5, MMP8
36dopamine44 28 24 1111.7GAD2, GAD1, TOR1A
37glucose448.6MMP8, IL18, GAD1, GAD2
38cholesterol44 28 24 1111.5IL18, F5, GAD1, GAD2
39alanine448.2GAD2, GAD1, F5, IL18, MMP8
40cysteine448.1MMP8, IL18, F5, GAD1, GAD2
41tyrosine448.1GAD2, GAD1, IL9, IL18, TOR1A
42glutamate448.0TOR1A, IL18, F5, GAD1, GAD2
43nitric oxide44 24 119.7GAD2, GAD1, F5, IL9, IL18, MMP8
44calcium44 50 24 1110.4MMP8, IL18, F5, GAD1, GAD2

GO Terms for genes affiliated with Cerebral Palsy

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Cellular components related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coated pitGO:0059059.4AP4S1, AP4B1, AP4E1
2clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.0GAD2, GAD1
3extracellular spaceGO:0056158.5F5, IL9, IL18, MMP8

Biological processes related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurotransmitter secretionGO:0072699.3GAD2, GAD1
2glutamate decarboxylation to succinateGO:0065409.2GAD2, GAD1
3neurotransmitter biosynthetic processGO:0421369.0GAD2, GAD1

Molecular functions related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein transporter activityGO:0085659.9AP4S1, AP4B1
2glutamate decarboxylase activityGO:0043519.3GAD2, GAD1
3glutamate bindingGO:0165959.3GAD2, GAD1
4pyridoxal phosphate bindingGO:0301709.0GAD2, GAD1
5serine-type endopeptidase activityGO:0042528.8MMP8, TOR1A, F5

Products for genes affiliated with Cerebral Palsy

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  • Antibodies
  • Proteins
  • Lysates

Sources for Cerebral Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet