MCID: CRB037
MIFTS: 64

Cerebral Palsy malady

Neuronal diseases category

Summaries for Cerebral Palsy

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cerebral palsy is a group of disorders that affect a person's ability to move and to maintain balance and posture. the disorders appear in the first few years of life. usually they do not get worse over time. people with cerebral palsy may have difficulty walking. they may also have trouble with tasks such as writing or using scissors. some have other medical conditions, including seizure disorders or mental impairment. cerebral palsy happens when the areas of the brain that control movement and posture do not develop correctly or get damaged. early signs of cerebral palsy usually appear before 3 years of age. babies with cerebral palsy are often slow to roll over, sit, crawl, smile, or walk. some babies are born with cerebral palsy; others get it after they are born. there is no cure for cerebral palsy, but treatment can improve the lives of those who have it. treatment includes medicines, braces, and physical, occupational and speech therapy. nih: national institute of neurological disorders and stroke

MalaCards: Cerebral Palsy, also known as infantile cerebral palsy, is related to ataxic cerebral palsy and spastic quadriplegia. An important gene associated with Cerebral Palsy is KANK1 (KN motif and ankyrin repeat domains 1), and among its related pathways are Lysosome and Allograft rejection. The drugs baclofen and dantrolene and the compounds alanine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

NINDS:43 The term cerebral palsy refers to any one of a number of neurological disorders that appear in infancy or early childhood and permanently affect body movement and muscle coordination but don?t worsen over time.

Wikipedia:63 Cerebral palsy (CP) is a general term for a group of permanent, non-progressive movement disorders that... more...

Aliases & Classifications for Cerebral Palsy

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

cerebral palsy 8 42 43 10 44 33 30 60
infantile cerebral palsy 8 60
cerebral palsy, mixed 60
mixed cerebral palsy 42
cerebral palsy, nos 8
cerebral palsy nos 8


External Ids:

Disease Ontology8 DOID:1969
NCIt39 C34460
MeSH34 D002547
ICD1025 G80

Related Diseases for Cerebral Palsy

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cerebral Palsy:



Diseases related to cerebral palsy

Clinical Features for Cerebral Palsy

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Drugs & Therapeutics for Cerebral Palsy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebral Palsy

Drug clinical trials:

Search ClinicalTrials for Cerebral Palsy

Search NIH Clinical Center for Cerebral Palsy

Search CenterWatch for Cerebral Palsy

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Cerebral Palsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells for treatment of cerebral palsy
Embryonic/Adult Cultured Cells Related to Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells (family)

Genetic Tests for Cerebral Palsy

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Anatomical Context for Cerebral Palsy

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Cerebral Palsy:

32
Brain, Testes, Bone, Heart, Cortex, Eye, Colon, Dorsal root ganglion, Skeletal muscle, Bone marrow, Spinal cord, Tongue

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Cerebral Palsy:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Cerebral Palsy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cerebral Palsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6AP4E1, NPHS1, GAD2, GAD1, DMD, F5
2MP:000363110.5GAD1, PLP1, NETO2, TOR1A, F5, DMD
3MP:000538610.3PLP1, UBE3A, SIRPA, MNX1, TOR1A, F5

Publications for Cerebral Palsy

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50PubMed
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Articles related to Cerebral Palsy:

(show top 50)    (show all 1203)
idTitleAuthorsYear
1
Instrumented assessment of the effect of Botulinum Toxin-A in the medial hamstrings in children with cerebral palsy. (23791154)
2014
2
Muscle-tendon lengths according to sagittal knee kinematics in patients with cerebral palsy: differences between recurvatum and crouch knee. (23969563)
2014
3
The effect of continuous intrathecal baclofen on sitting in children with severe cerebral palsy. (24100173)
2014
4
Sensory feedback to ankle plantar flexors is not exaggerated during gait in spastic children with cerebral palsy. (24225545)
2013
5
Botulinum toxin-A with and without rehabilitation for the treatment of spastic cerebral palsy. (23696596)
2013
6
Bilateral submandibular duct rerouting: assessment of results on drooling in cerebral palsy cases. (23489831)
2013
7
Social support provided to caregivers of children with cerebral palsy. (23734935)
2013
8
Does somatosensory discrimination activate different brain areas in children with unilateral cerebral palsy compared to typically developing children? An fMRI study. (23500165)
2013
9
Laminoplasty and pedicle screw fixation for cervical myelopathy associated with athetoid cerebral palsy: minimum 5-year follow-up. (23759815)
2013
10
Hip surveillance and management of the displaced hip in cerebral palsy. (24432103)
2013
11
Low-contrast acuity measurement: does it add value in the visual assessment of down syndrome and cerebral palsy populations? (23233262)
2013
12
Rootless century: posterior rhizotomy for spastic cerebral palsy. (23264603)
2013
13
Airway obstruction in children with cerebral palsy: need for tracheostomy? (23947996)
2013
14
Musculoskeletal modelling of cerebral palsy children: sensitivity analysis of musculoskeletal model parameter's values for gait analysis. (23923890)
2013
15
Surgical outcomes of medial rectus recession in esotropia with cerebral palsy. (23218820)
2013
16
Effect of strength training of ankle plantarflexors on selective voluntary motor control, gait parameters, and gross motor function of children with cerebral palsy. (24259771)
2013
17
On the control of brain-computer interfaces by users with cerebral palsy. (23684128)
2013
18
A clinical measurement to quantify spasticity in children with cerebral palsy by integration of multidimensional signals. (23218728)
2013
19
Magnesium sulphate for the prevention of cerebral palsy in Australia and New Zealand. (23930314)
2013
20
Face and construct validity of the Gait Deviation Index in adults with spastic cerebral palsy. (22214985)
2012
21
Spastic cerebral palsy in children: dynamic sonoelastographic findings of medial gastrocnemius. (22495685)
2012
22
Classification of topographical pattern of spasticity in cerebral palsy: a registry perspective. (21624819)
2011
23
Causal relation between spasticity, strength, gross motor function, and functional outcome in children with cerebral palsy: a path analysis. (21126242)
2011
24
Hip lateralisation in children with bilateral spastic cerebral palsy treated with botulinum toxin type A: a 2-year follow-up. (21500143)
2011
25
Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. (20101040)
2010
26
Percutaneous radiofrequency lesions adjacent to the dorsal root ganglion alleviate spasticity and pain in children with cerebral palsy: pilot study in 17 patients. (20569438)
2010
27
Walking ability and predictors of performance on the 6-minute walk test in adults with spastic cerebral palsy. (20163429)
2010
28
Application of botulinum toxin in treatment of spasticity and functional improvements for children suffering from cerebral palsy. (21218755)
2010
29
Hip subluxation and dislocation in cerebral palsy: outcome of bone surgery in 21 hips. (19058693)
2008
30
The surgical management of thumb deformity in cerebral palsy. (18332025)
2008
31
Effectiveness of a triclosan/copolymer dentifrice on dental plaque and gingivitis in Brazilian individuals with cerebral palsy. (17972445)
2007
32
Oxygen cost versus a 1-minute walk test in a population of children with bilateral spastic cerebral palsy. (17414010)
2007
33
The effect of community-prescribed ankle-foot orthoses on gait parameters in children with spastic cerebral palsy. (19308527)
2007
34
Decreased chest mobility in children with spastic cerebral palsy. (17290570)
2006
35
Very high serum creatine kinase level in a child with dyskinetic cerebral palsy. (12142071)
2002
36
Hip displacement in spastic cerebral palsy: repeatability of radiologic measurement. (12198471)
2002
37
Early mobilization after sliding achilles tendon lengthening in children with spastic cerebral palsy. (11139029)
2000
38
Baclofen infusion for spastic cerebral palsy. (11197716)
2000
39
Common abnormal kinetic patterns of the knee in gait in spastic diplegia of cerebral palsy. (10802435)
2000
40
A gene for autosomal recessive symmetrical spastic cerebral palsy maps to chromosome 2q24-25. (9973289)
1999
41
Factor V Leiden as a cause of hemiplegic cerebral palsy, neonatal stroke, and placental thrombosis? (9749620)
1998
42
MRI findings in patients with spastic cerebral palsy. II: Correlation with type of cerebral palsy. (9233360)
1997
43
Hip subluxation in cerebral palsy: what should be done for the spastic child with hip subluxation? (9591992)
1997
44
Muscle histopathology in spastic cerebral palsy. (8879649)
1996
45
The effects of neurodevelopmental treatment versus practice on the reaching of children with spastic cerebral palsy. (8606898)
1996
46
Adductor and psoas release for subluxation of the hip in children with spastic cerebral palsy. (7593584)
1995
47
Gait laboratory analysis for preoperative decision making in spastic cerebral palsy: is it all it's cracked up to be? (7814579)
1994
48
Subacute cervical myelopathy in a child with cerebral palsy. Secondary to torsion dystonia? (7128247)
1982
49
Spastic cerebral palsy: changes in birthweight and gestational age. (7249994)
1981
50
Cerebral palsy and juvenile glaucoma in siblings. (5457541)
1970

Genetic Variations for Cerebral Palsy

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Expression for genes affiliated with Cerebral Palsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Palsy

Search GEO for disease gene expression data for Cerebral Palsy.

Pathways for genes affiliated with Cerebral Palsy

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Cerebral Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5AP4B1, AP4E1, AP4M1, AP4S1
2
Hide members
10.5IL9, GAD1, GAD2, DMD
3
Hide members
10.5GAD2, GAD1
410.5GAD2, GAD1
510.5GAD2, GAD1
610.5GAD2, GAD1
710.5GAD2, GAD1
8
Hide members
10.5GAD1, GAD2

Compounds for genes affiliated with Cerebral Palsy

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Cerebral Palsy according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1alanine4410.9UBE3A, GAD2, GAD1, DMD, F5, MNX1
2nitric oxide44 11 2412.9SIRPA, GAD2, GAD1, DMD, F5, IL9
3cysteine4410.9UBE3A, GAD2, GAD1, DMD, F5, MMP8
4oligonucleotide4410.9GAD2, GAD1, DMD, IL9, MMP8, PLP1
5tyrosine4410.9UBE3A, NPHS1, GAD2, GAD1, DMD, TOR1A
6proline4410.9GAD2, GAD1, DMD, F5, MMP8
7gaba4410.8PLP1, GAD1, GAD2, UBE3A
8cysteine sulfinic acid4410.8GAD2, GAD1
9retinoic acid44 2411.8NPHS1, F5, MNX1, IL9, MMP8, PLP1
10hypotaurine59 44 2412.8GAD1, GAD2
113-Sulfinoalanine11 2411.8GAD1, GAD2
12glucose4410.8NPHS1, GAD2, GAD1, DMD, MMP8, SIRPA
13acetylcholine44 49 28 11 2414.8PLP1, DMD, GAD1, GAD2
14calcium44 49 11 2413.8NPHS1, GAD2, GAD1, DMD, F5, MMP8
15ornithine44 2411.8GAD2, GAD1, DMD
16cacl24410.7MMP8, F5
17pyridoxal44 11 2412.7GAD1, GAD2
18urea44 11 2412.7DMD, F5, MMP8
19gold4410.7DMD, GAD1, UBE3A
20hind iii4410.6F5, DMD
21bromodeoxyuridine4410.6GAD1, DMD, IL9
22arginine4410.6PLP1, F5, DMD, GAD1, NPHS1
23cyclosporin a44 28 5912.5MMP8, DMD, GAD1, GAD2
24lipid4410.5NPHS1, DMD, IL9, MMP8, SIRPA, PLP1
25L-Aspartic Acid11 2411.4GAD2, GAD1
26benzodiazepine4410.2UBE3A, GAD1

GO Terms for genes affiliated with Cerebral Palsy

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16Gene Ontology
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Cellular components related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin adaptor complexGO:03013110.5AP4B1, AP4M1
2clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.2GAD1, GAD2

Biological processes related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vesicle-mediated transportGO:01619210.5AP4B1, AP4M1, AP4E1
2glutamate decarboxylation to succinateGO:00654010.4GAD1, GAD2
3neurotransmitter biosynthetic processGO:04213610.2GAD1, GAD2

Molecular functions related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin bindingGO:01702210.5DMD, NPHS1
2glutamate decarboxylase activityGO:00435110.4GAD1, GAD2
3glutamate bindingGO:01659510.2GAD1, GAD2

Products for genes affiliated with Cerebral Palsy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet