MCID: CRB037
MIFTS: 58

Cerebral Palsy malady

Neuronal category

Summaries for Cerebral Palsy

Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Cerebral palsy is a group of disorders that affect a person's ability to move and to maintain balance and posture. the disorders appear in the first few years of life. usually they do not get worse over time. people with cerebral palsy may have difficulty walking. they may also have trouble with tasks such as writing or using scissors. some have other medical conditions, including seizure disorders or mental impairment. cerebral palsy happens when the areas of the brain that control movement and posture do not develop correctly or get damaged. early signs of cerebral palsy usually appear before 3 years of age. babies with cerebral palsy are often slow to roll over, sit, crawl, smile, or walk. some babies are born with cerebral palsy; others get it after they are born. there is no cure for cerebral palsy, but treatment can improve the lives of those who have it. treatment includes medicines, braces, and physical, occupational and speech therapy. nih: national institute of neurological disorders and stroke

MalaCards: Cerebral Palsy, also known as infantile cerebral palsy, is related to ataxic cerebral palsy and spastic quadriplegia. An important gene associated with Cerebral Palsy is KANK1 (KN motif and ankyrin repeat domains 1), and among its related pathways are Lysosome and Allograft rejection. The drugs baclofen and dantrolene and the compounds alanine and nitric oxide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

NINDS:44 The term cerebral palsy refers to any one of a number of neurological disorders that appear in infancy or early childhood and permanently affect body movement and muscle coordination but don?t worsen over time.

Wikipedia:64 Cerebral palsy (CP) is an umbrella term denoting a group of non-progressive, non-contagious motor... more...

Aliases & Classifications for Cerebral Palsy

Sources:
43NIH Rare Diseases, 8Disease Ontology, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

cerebral palsy 8 43 44 10 45 34 31 61
infantile cerebral palsy 8 61
cerebral palsy, mixed 61
mixed cerebral palsy 43
cerebral palsy, nos 8
cerebral palsy nos 8


External Ids:

Disease Ontology8 DOID:1969
NCIt40 C34460
MeSH35 D002547
ICD1025 G80

Related Diseases for Cerebral Palsy

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Cerebral Palsy:



Diseases related to cerebral palsy

Clinical Features for Cerebral Palsy

Drugs & Therapeutics for Cerebral Palsy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cerebral Palsy

Drug clinical trials:

Search ClinicalTrials for Cerebral Palsy

Search NIH Clinical Center for Cerebral Palsy

Search CenterWatch for Cerebral Palsy

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Cerebral Palsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells for treatment of cerebral palsy
Embryonic/Adult Cultured Cells Related to Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells (family)

Genetic Tests for Cerebral Palsy

Anatomical Context for Cerebral Palsy

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Cerebral Palsy:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Cerebral Palsy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cerebral Palsy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6AP4E1, NPHS1, GAD2, GAD1, DMD, F5
2MP:000363110.5GAD1, PLP1, NETO2, TOR1A, F5, DMD
3MP:000538610.3PLP1, UBE3A, SIRPA, MNX1, TOR1A, F5

Publications for Cerebral Palsy

Sources:
51PubMed
See all sources

Articles related to Cerebral Palsy:

(show top 50)    (show all 1200)
idTitleAuthorsYear
1
Diffusion tensor imaging in a patient with cerebral palsy and hypersomnia. (24269132)
2014
2
Effects of a recreational ice skating program on the functional mobility of a child with cerebral palsy. (24328904)
2013
3
Rehabilitation of 190A non-ambulatory children with cerebral palsy in structures of care or in liberal sector. (24120244)
2013
4
A Kinect-based upper limb rehabilitation system to assist people with cerebral palsy. (24012594)
2013
5
Astrocytes and microglia in acute cerebral injury underlying cerebral palsy associated with preterm birth. (24336433)
2013
6
Mental health in children with cerebral palsy: does screening capture the complexity? (23690745)
2013
7
The six-minute walk test cannot predict peak cardiopulmonary fitness in ambulatory adolescents and young adults with cerebral palsy. (23796684)
2013
8
Use of eye-pointing by children with cerebral palsy: what are we looking at? (24033647)
2013
9
Musculoskeletal modelling of cerebral palsy children: sensitivity analysis of musculoskeletal model parameter's values for gait analysis. (23923890)
2013
10
Surgical outcomes of medial rectus recession in esotropia with cerebral palsy. (23218820)
2013
11
Effect of strength training of ankle plantarflexors on selective voluntary motor control, gait parameters, and gross motor function of children with cerebral palsy. (24259771)
2013
12
The epidemiology of cerebral palsy: new perspectives from a Canadian registry. (23948680)
2013
13
Risk factors and complications in hip reconstruction for nonambulatory patients with cerebral palsy. (24432112)
2013
14
Cerebral palsy prevention and cure: Vision or mirage? A personal view. (23711208)
2013
15
Developmental trajectories of social participation in individuals with cerebral palsy: a multi-centre longitudinal study. (24359158)
2013
16
The relationship between spasticity and muscle volume of the knee extensors in children with cerebral palsy. (22466388)
2012
17
A Comparative Assessment of Motor Function using the Expanded and Revised Gross Motor Function Classification System and the Manual Ability Classification System in the same Children with Cerebral Palsy in Shika, Zaria, Northwestern Nigeria. (23468021)
2012
18
A 7q11.23 microduplication patient with cerebral palsy and facial dysmorphism. (22876586)
2012
19
Neuroleptic malignant syndrome associated with the use of carbidopa/levodopa for dystonia in persons with cerebral palsy. (22613365)
2012
20
Identifying loss of function caused by cervical spondylotic myelopathy in young adults with nonathetoid spastic cerebral palsy. (23093221)
2012
21
Computer-mediated support for adolescents with cerebral palsy or spina bifida. (21099541)
2011
22
Effects of botulinum toxin A in ambulant adults with spastic cerebral palsy: a randomized double-blind placebo controlled-trial. (21305227)
2011
23
Uncovering the complex relationship between pre-eclampsia, preterm birth and cerebral palsy. (21281322)
2011
24
Causal relation between spasticity, strength, gross motor function, and functional outcome in children with cerebral palsy: a path analysis. (21126242)
2011
25
Hip lateralisation in children with bilateral spastic cerebral palsy treated with botulinum toxin type A: a 2-year follow-up. (21500143)
2011
26
Growth hormone deficiency and cerebral palsy. (20856687)
2010
27
Apolipoprotein E genotype and cerebral palsy. (20002130)
2010
28
Walking ability and predictors of performance on the 6-minute walk test in adults with spastic cerebral palsy. (20163429)
2010
29
Application of botulinum toxin in treatment of spasticity and functional improvements for children suffering from cerebral palsy. (21218755)
2010
30
Increases in muscle volume after plantarflexor strength training in children with spastic cerebral palsy. (19170722)
2009
31
Disappearance of spasticity after selective dorsal rhizotomy does not prevent muscle shortening in children with cerebral palsy: a case report. (19151363)
2009
32
Hip subluxation and dislocation in cerebral palsy - a prospective study on the effectiveness of postural management programmes. (19194957)
2009
33
The genomic basis of cerebral palsy: a HuGE systematic literature review. (19238444)
2009
34
Effect of serial casting in spastic cerebral palsy. (18574577)
2008
35
Continuous intrathecal baclofen infusion for intractable spastic cerebral palsy--is it worth it? (18665144)
2008
36
Massive prepatellar bursitis in cerebral palsy. (17371643)
2007
37
Factitious buccal lesion secondary to bruxism in a child with cerebral palsy. (16373789)
2006
38
Arm trajectories in dyskinetic cerebral palsy have increased random variability. (16970842)
2006
39
Letter to the JPO editors re: article by Andreacchio et al entitled "lateral column lengthening as treatment for planovalgus foot deformity in ambulatory children with spastic cerebral palsy" (J Pediatr Orthop 2000;20:501-505). (16670559)
2006
40
Entrapment neuropathy in patients with spastic cerebral palsy. (16097960)
2005
41
Deletion of the ANKRD15 gene at 9p24.3 causes parent-of-origin- dependent inheritance of familial cerebral palsy. (16301218)
2005
42
Upper extremity performance and self-care skill changes in children with spastic cerebral palsy following selective posterior rhizotomy. (9876248)
1998
43
The effects of neurodevelopmental treatment versus practice on the reaching of children with spastic cerebral palsy. (8606898)
1996
44
Partial NADH dehydrogenase defect presenting as spastic cerebral palsy. (7892959)
1994
45
Gait laboratory analysis for preoperative decision making in spastic cerebral palsy: is it all it's cracked up to be? (7814579)
1994
46
Dynamic monitoring of sitting posture for children with spastic cerebral palsy. (23915533)
1991
47
The Frank Stinchfield Award Paper. Internal rotation gait in spastic cerebral palsy. (7166508)
1982
48
Subacute cervical myelopathy in a child with cerebral palsy. Secondary to torsion dystonia? (7128247)
1982
49
Spastic cerebral palsy: changes in birthweight and gestational age. (7249994)
1981
50
Operant control of pathological tongue thrust in spastic cerebral palsy. (511801)
1979

Genetic Variations for Cerebral Palsy

Expression for genes affiliated with Cerebral Palsy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cerebral Palsy

Search GEO for disease gene expression data for Cerebral Palsy.

Pathways for genes affiliated with Cerebral Palsy

Sources:
30KEGG, 12EMD Millipore, 54Reactome, 38NCBI BioSystems Database
See all sources

Pathways related to Cerebral Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5AP4E1, AP4M1, AP4S1, AP4B1
2
Hide members
10.5IL9, DMD, GAD1, GAD2
310.5GAD2, GAD1
4
Hide members
10.5GAD1, GAD2
5
Hide members
10.5GAD1, GAD2
610.5GAD1, GAD2
710.5GAD1, GAD2
810.5GAD1, GAD2

Compounds for genes affiliated with Cerebral Palsy

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Cerebral Palsy according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1alanine4510.9UBE3A, GAD2, GAD1, DMD, F5, MNX1
2nitric oxide45 11 2412.9SIRPA, GAD2, GAD1, DMD, F5, IL9
3cysteine4510.9UBE3A, GAD2, GAD1, DMD, F5, MMP8
4oligonucleotide4510.9GAD2, GAD1, DMD, IL9, MMP8, PLP1
5tyrosine4510.9UBE3A, NPHS1, GAD2, GAD1, DMD, TOR1A
6proline4510.9GAD2, GAD1, DMD, F5, MMP8
7gaba4510.8PLP1, GAD1, GAD2, UBE3A
8cysteine sulfinic acid4510.8GAD2, GAD1
9retinoic acid45 2411.8NPHS1, F5, MNX1, IL9, MMP8, PLP1
10hypotaurine60 45 2412.8GAD1, GAD2
113-Sulfinoalanine11 2411.8GAD1, GAD2
12glucose4510.8NPHS1, GAD2, GAD1, DMD, MMP8, SIRPA
13acetylcholine45 50 29 11 2414.8PLP1, DMD, GAD1, GAD2
14calcium45 50 11 2413.8NPHS1, GAD2, GAD1, DMD, F5, MMP8
15ornithine45 2411.8GAD2, GAD1, DMD
16cacl24510.7MMP8, F5
17pyridoxal45 11 2412.7GAD1, GAD2
18urea45 11 2412.7DMD, F5, MMP8
19gold4510.7DMD, GAD1, UBE3A
20hind iii4510.6F5, DMD
21bromodeoxyuridine4510.6GAD1, DMD, IL9
22arginine4510.6PLP1, F5, DMD, GAD1, NPHS1
23cyclosporin a45 29 6012.5MMP8, DMD, GAD1, GAD2
24lipid4510.5NPHS1, DMD, IL9, MMP8, SIRPA, PLP1
25L-Aspartic Acid11 2411.4GAD2, GAD1
26benzodiazepine4510.2UBE3A, GAD1

GO Terms for genes affiliated with Cerebral Palsy

Sources:
16Gene Ontology
See all sources

Cellular components related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin adaptor complexGO:03013110.5AP4B1, AP4M1
2clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.2GAD1, GAD2

Biological processes related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vesicle-mediated transportGO:01619210.5AP4B1, AP4M1, AP4E1
2glutamate decarboxylation to succinateGO:00654010.4GAD1, GAD2
3neurotransmitter biosynthetic processGO:04213610.2GAD1, GAD2

Molecular functions related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin bindingGO:01702210.5DMD, NPHS1
2glutamate decarboxylase activityGO:00435110.4GAD1, GAD2
3glutamate bindingGO:01659510.2GAD1, GAD2

Products for genes affiliated with Cerebral Palsy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Palsy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet