MCID: CRB037
MIFTS: 65

Cerebral Palsy malady

Rare diseases, Neuronal diseases categories
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Summaries for Cerebral Palsy

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Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Cerebral palsy is a group of disorders that affect a person's ability to move and to maintain balance and posture. the disorders appear in the first few years of life. usually they do not get worse over time. people with cerebral palsy may have difficulty walking. they may also have trouble with tasks such as writing or using scissors. some have other medical conditions, including seizure disorders or mental impairment. cerebral palsy happens when the areas of the brain that control movement and posture do not develop correctly or get damaged. early signs of cerebral palsy usually appear before 3 years of age. babies with cerebral palsy are often slow to roll over, sit, crawl, smile, or walk. some babies are born with cerebral palsy; others get it after they are born. there is no cure for cerebral palsy, but treatment can improve the lives of those who have it. treatment includes medicines, braces, and physical, occupational and speech therapy. nih: national institute of neurological disorders and stroke

MalaCards: Cerebral Palsy, also known as infantile cerebral palsy, is related to stiff-person syndrome and cerebritis. An important gene associated with Cerebral Palsy is KANK1 (KN motif and ankyrin repeat domains 1), and among its related pathways are Lysosome and Cytokine Network. The drugs baclofen and dantrolene and the compounds alendronate and cacl2 have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are digestive/alimentary and behavior/neurological.

Disease Ontology:8 A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

NINDS:44 The term cerebral palsy refers to any one of a number of neurological disorders that appear in infancy or early childhood and permanently affect body movement and muscle coordination but don?t worsen over time.

Wikipedia:65 Cerebral palsy (CP) is a general term for a group of permanent, non-progressive movement disorders that... more...

Aliases & Classifications for Cerebral Palsy

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8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

cerebral palsy 8 43 44 10 45 34 31 62
infantile cerebral palsy 8 62
cerebral palsy, mixed 62
mixed cerebral palsy 43
cerebral palsy, nos 8
cerebral palsy nos 8


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Disease Ontology8 DOID:1969
NCIt40 C34460
MeSH35 D002547
ICD1025 G80

Related Diseases for Cerebral Palsy

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cerebral Palsy:



Diseases related to cerebral palsy

Symptoms for Cerebral Palsy

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Drugs & Therapeutics for Cerebral Palsy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cerebral Palsy

Search NIH Clinical Center for Cerebral Palsy

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Cerebral Palsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells for treatment of cerebral palsy
Embryonic/Adult Cultured Cells Related to Cerebral Palsy:
Umbilical cord-derived mesenchymal stem cells (family)

Genetic Tests for Cerebral Palsy

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Anatomical Context for Cerebral Palsy

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Cerebral Palsy:

33
Brain, Testes, Bone, Heart, Eye, Cortex, Colon, Dorsal root ganglion, Skeletal muscle, Bone marrow, Spinal cord, Tongue

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Cerebral Palsy:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Cerebral Palsy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cerebral Palsy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3GAD2, GAD1, IL9, IL18
2MP:00053867.0GAD2, AP4E1, AP4B1, TOR1A, IL18, F5
3MP:00036316.9AP4E1, AP4B1, TOR1A, IL18, F5, GAD1
4MP:00053766.5AP4E1, TOR1A, IL18, IL9, F5, GAD1

Publications for Cerebral Palsy

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Sources:
52PubMed
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Articles related to Cerebral Palsy:

(show top 50)    (show all 1163)
idTitleAuthorsYear
1
Surgical intervention for feeding and nutrition difficulties in cerebral palsy: a systematic review. (23738903)
2014
2
Tendon structure and extracellular matrix components are affected by spasticity in cerebral palsy patients. (23885344)
2013
3
Sensory feedback to ankle plantar flexors is not exaggerated during gait in spastic children with cerebral palsy. (24225545)
2013
4
Life care planning for the child with cerebral palsy. (23910487)
2013
5
A systematic review of activities of daily living measures for children and adolescents with cerebral palsy. (23937056)
2013
6
Pelizaeus-Merzbacher Disease, Easily Misdiagnosed as Cerebral Palsy: A Report of a Three-generation Family. (23597542)
2013
7
Reliability of Fractional Anisotropy Measurement for Children with Cerebral Palsy. (24122275)
2013
8
Geographical patterns in the recreation and leisure participation of children and youth with cerebral palsy: a CAPE international collaborative network study. (23477429)
2013
9
Atrophy and hypertrophy following injections of botulinum toxin in children with cerebral palsy. (23859067)
2013
10
Botulinum Toxin Treatment on Upper Limb Function in School Age Children With Bilateral Spastic Cerebral Palsy: One Year Follow-up. (23869330)
2013
11
Early prediction of cerebral palsy after neonatal intensive care using motor development trajectories in infancy. (23856349)
2013
12
Interlimb coordination during forward walking is largely preserved in backward walking in children with cerebral palsy. (24079947)
2013
13
Outcomes of rectus femoris transfers in children with cerebral palsy: effect of transfer site. (23482268)
2013
14
A comparison study of depression and quality of life in Turkish mothers of children with Down syndrome, cerebral palsy, and autism spectrum disorder. (23654042)
2013
15
Speech and language development in 2-year-old children with cerebral palsy. (23627373)
2013
16
Rotational osteotomy with submuscular plating in skeletally immature patients with cerebral palsy. (23579357)
2013
17
Selective dorsal rhizotomy for spasticity not associated with cerebral palsy: reconsideration of surgical inclusion criteria. (24175866)
2013
18
Predictors for changes in various developmental outcomes of children with cerebral palsy--a longitudinal study. (24025438)
2013
19
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial. (24112817)
2013
20
A comparison of treadmill training and overground walking in ambulant children with cerebral palsy: randomized controlled clinical trial. (23503736)
2013
21
Effects of a recreational ice skating program on the functional mobility of a child with cerebral palsy. (24328904)
2013
22
Development and validity of the early clinical assessment of balance for young children with cerebral palsy. (24087912)
2013
23
Botulinum toxin-A with and without rehabilitation for the treatment of spastic cerebral palsy. (23696596)
2013
24
Nutrition and growth in children with cerebral palsy: setting the scene. (24301006)
2013
25
The relationship between spasticity and muscle volume of the knee extensors in children with cerebral palsy. (22466388)
2012
26
Visual impairment in children with spastic cerebral palsy measured by psychophysical and electrophysiological grating acuity tests. (23030659)
2012
27
Outcomes of correction of internal hip rotation in patients with spastic cerebral palsy using proximal femoral osteotomy. (22425638)
2012
28
A comparison of activity, participation and quality of life in children with and without spastic diplegia cerebral palsy. (22200241)
2012
29
A Comparative Assessment of Motor Function using the Expanded and Revised Gross Motor Function Classification System and the Manual Ability Classification System in the same Children with Cerebral Palsy in Shika, Zaria, Northwestern Nigeria. (23468021)
2012
30
Spinal arteriovenous malformation presenting as spastic monoplegic cerebral palsy in a child. (20546106)
2012
31
Computer-mediated support for adolescents with cerebral palsy or spina bifida. (21099541)
2011
32
Muscle volume and motor development in spastic cerebral palsy. (21574987)
2011
33
Surgical management of spasticity in persons with cerebral palsy. (19769917)
2009
34
Mutation in the AP4M1 gene provides a model for neuroaxonal injury in cerebral palsy. (19559397)
2009
35
Motor impairments and activity limitations in children with spastic cerebral palsy: a Dutch population-based study. (19363571)
2009
36
The dependence of spinal cord development on corticospinal input and its significance in understanding and treating spastic cerebral palsy. (17544509)
2007
37
Effects of surgical adductor releases for hip subluxation in cerebral palsy: an AACPDM evidence report. (15344524)
2004
38
Changes in hip spasticity and strength following selective dorsal rhizotomy and physical therapy for spastic cerebral palsy. (11995889)
2002
39
Very high serum creatine kinase level in a child with dyskinetic cerebral palsy. (12142071)
2002
40
Surgery for cerebral palsy part 3: classification and operative procedures for thumb deformity. (11560430)
2001
41
Preterm infants with athetoid cerebral palsy: kernicterus? (11207234)
2001
42
A case of 3-methylglutaconic aciduria misdiagnosed as cerebral palsy. (11118804)
2000
43
Early mobilization after sliding achilles tendon lengthening in children with spastic cerebral palsy. (11139029)
2000
44
Intrathecal baclofen for management of spastic cerebral palsy: multicenter trial. (10695888)
2000
45
Can children with spastic cerebral palsy use self-hypnosis to reduce muscle tone? a preliminary study. (10882882)
2000
46
Stance balance control with orthoses in a group of children with spastic cerebral palsy. (10576639)
1999
47
MRI findings and sensorimotor development in infants with bilateral spastic cerebral palsy. (9187473)
1997
48
Cerebral palsy of cystic periventricular leukomalacia in low-birth-weight infants. (8025396)
1994
49
Knee flexion deformity and patella alta in spastic cerebral palsy. (939346)
1976
50
Hip-flexion deformity in spastic cerebral palsy. (5128794)
1971

Variations for Cerebral Palsy

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Expression for genes affiliated with Cerebral Palsy

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebral Palsy

Search GEO for disease gene expression data for Cerebral Palsy.

Pathways for genes affiliated with Cerebral Palsy

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Sources:
50PathCards, 30KEGG, 53QIAGEN, 12EMD Millipore, 54R&D Systems, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Cerebral Palsy according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5AP4E1, AP4B1, AP4S1
29.5IL18, IL9
3
Show member pathways
9.3GAD2, GAD1
4
Show member pathways
phenylethylamine degradation I38
9.3GAD2, GAD1
59.3GAD2, GAD1
6
Show member pathways
9.3GAD2, GAD1
7
Show member pathways
catecholamine biosynthesis38
9.3GAD2, GAD1
8
Show member pathways
9.3GAD2, GAD1
99.3GAD2, GAD1
10
Show member pathways
9.3GAD2, GAD1
11
Show member pathways
9.3GAD2, GAD1
12
Show member pathways
9.3GAD1, GAD2
138.8GAD2, GAD1, TOR1A
14
Show member pathways
8.3GAD2, GAD1, IL9, IL18

Compounds for genes affiliated with Cerebral Palsy

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Cerebral Palsy according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1alendronate45 51 1111.9MMP8, IL18
2cacl2459.8MMP8, F5
3vitamin b6459.8GAD1, F5
4nafamostat mesilate459.8IL18, F5
5tarc459.7IL9, IL18
6Cysteic acid249.7GAD2, GAD1
7cysteine sulfinic acid459.7GAD2, GAD1
8hypotaurine61 45 2411.7GAD2, GAD1
9ciprofloxacin45 51 1111.7IL18, F5
103-Sulfinoalanine24 1110.7GAD2, GAD1
11pyridoxal45 24 1111.7GAD1, GAD2
12L-Aspartic acid24 1110.7GAD2, GAD1
13beta-alanine45 61 29 24 1113.6GAD2, GAD1
14Gamma-Aminobutyric acid249.6GAD2, GAD1
15taurine45 61 2411.6GAD1, GAD2
16mycophenolate mofetil45 51 1111.6F5, IL18
17allergens459.6IL18, IL9
18pyridoxal 5-phosphate459.6GAD2, GAD1
19mptp459.5GAD2, GAD1
20Pyridoxal 5'-phosphate249.5GAD2, GAD1
21c-peptide459.4GAD2, GAD1
22tetrodotoxin45 61 2911.4GAD2, GAD1
23p002459.3MMP8, IL18, F5
24fibrinogen459.2MMP8, IL18, F5
25famotidine45 3 24 1112.2IL18, GAD1, GAD2
26glutamine459.1IL18, F5, GAD1
27acetylcholine45 51 29 24 1113.1GAD2, GAD1, IL18
28progesterone45 29 61 24 1112.9GAD1, F5, IL18, MMP8
29lactate458.9F5, IL18, MMP8
30oligonucleotide458.8MMP8, IL9, GAD1, GAD2
31cyclosporin a45 29 6110.8MMP8, IL18, GAD1, GAD2
32retinoic acid45 249.8MMP8, IL18, IL9, F5
33hydrogen45 249.8GAD2, GAD1, IL18, MMP8
34thymidine45 249.7GAD2, IL9, IL18
35proline458.7GAD2, GAD1, F5, MMP8
36dopamine45 29 24 1111.7GAD2, GAD1, TOR1A
37glucose458.6MMP8, IL18, GAD1, GAD2
38cholesterol45 29 24 1111.5IL18, F5, GAD1, GAD2
39alanine458.2GAD2, GAD1, F5, IL18, MMP8
40cysteine458.1MMP8, IL18, F5, GAD1, GAD2
41tyrosine458.1GAD2, GAD1, IL9, IL18, TOR1A
42glutamate458.0TOR1A, IL18, F5, GAD1, GAD2
43nitric oxide45 24 119.7GAD2, GAD1, F5, IL9, IL18, MMP8
44calcium45 51 24 1110.4MMP8, IL18, F5, GAD1, GAD2

GO Terms for genes affiliated with Cerebral Palsy

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16Gene Ontology
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Cellular components related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coated pitGO:0059059.4AP4S1, AP4B1, AP4E1
2clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.0GAD2, GAD1
3extracellular spaceGO:0056158.5F5, IL9, IL18, MMP8

Biological processes related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurotransmitter secretionGO:0072699.3GAD2, GAD1
2glutamate decarboxylation to succinateGO:0065409.2GAD2, GAD1
3neurotransmitter biosynthetic processGO:0421369.0GAD2, GAD1

Molecular functions related to Cerebral Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein transporter activityGO:0085659.9AP4S1, AP4B1
2glutamate decarboxylase activityGO:0043519.3GAD2, GAD1
3glutamate bindingGO:0165959.3GAD2, GAD1
4pyridoxal phosphate bindingGO:0301709.0GAD2, GAD1
5serine-type endopeptidase activityGO:0042528.8MMP8, TOR1A, F5

Products for genes affiliated with Cerebral Palsy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebral Palsy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet