Cerebritis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

MCID: CRB009 MIFTS: 56	Cerebritis malady
4399 genes, 50 tissues, 1550 related diseases, clinical trials.

Summaries for Cerebritis

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⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Cerebritis is an infection of the brain that normally leads to the formation of an abscess within the... more...

MalaCards: Cerebritis is related to alzheimer's disease and cadasil. An important gene associated with Cerebritis is APP (amyloid beta (A4) precursor protein), and among its related pathways is A-beta Plaque Formation & APP Metabolism . The compound methionine sulfoxide have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and endothelial, and related mouse phenotypes are normal and cardiovascular system.

Aliases & Classifications for Cerebritis

Sources:
⁸Disease Ontology, ⁶⁰UMLS, ³⁹NCIt
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Aliases & Descriptions:

cerebritis ⁸ ⁶⁰

External Ids:

Disease Ontology⁸ DOID:3431

NCIt³⁹ C27199

UMLS⁶⁰ C0742115

Related Diseases for Cerebritis

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Cerebritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 1550)

id	Related Disease	Score	Top Affiliating Genes
1	alzheimer's disease	31.1	NOTCH3, APP, CST3
2	cadasil	30.9	NOTCH3
3	stroke, ischemic	30.9	CCM2, KRIT1, NOTCH3
4	vascular disease	30.7	KRIT1, PDCD10, CCM2
5	cerebral cavernous malformation, familial	30.6	KRIT1, PDCD10, CCM2
6	cerebral cavernous malformation	30.5	KRIT1, PDCD10, CCM2
7	cerebrovascular disease	30.5	NOTCH3, KRIT1, APP, CST3
8	vascular dementia	30.4	NOTCH3
9	prion disease	30.1	CST3, APP
10	cerebral cavernous malformations-1	30.1	KRIT1
11	klippel-trenaunay syndrome	30.0	KRIT1, PDCD10, CCM2
12	familial cerebral cavernous malformation 2	29.7	CCM2
13	hemorrhage, intracerebral	29.6	CST3, APP, KRIT1
14	creutzfeldt-jakob syndrome	29.4	APP, CST3
15	cerebral palsy	11.1
16	ischemia	11.1
17	cerebral artery occlusion	11.0
18	cerebral malaria	11.0
19	malaria	11.0
20	cerebral amyloid angiopathy	11.0
21	spastic cerebral palsy	10.9
22	transient cerebral ischemia	10.9
23	neuronitis	10.8
24	middle cerebral artery infarction	10.8
25	cerebral atherosclerosis	10.7
26	atherosclerosis	10.7
27	hypertension	10.7
28	cerebral lymphoma	10.7
29	cerebral arterial disease	10.7
30	dementia	10.7
31	arteriovenous malformation	10.6
32	carotid artery occlusion	10.6
33	arteriosclerosis	10.6
34	meningitis	10.6
35	brain edema	10.6
36	moyamoya disease	10.6
37	cerebral degeneration	10.6
38	amyloidosis	10.6
39	hydrocephalus	10.5
40	plasmodium malariae malaria	10.5
41	vasculitis	10.5
42	phaeohyphomycosis	10.5
43	cerebral arteritis	10.5
44	adrenoleukodystrophy	10.5
45	migraine	10.5
46	hepatitis	10.5
47	multiple sclerosis	10.4
48	carotid stenosis	10.4
49	intracranial aneurysm	10.4
50	cerebral neuroblastoma	10.4

Graphical network of the top 20 diseases related to Cerebritis:

Clinical Features for Cerebritis

Drugs & Therapeutics for Cerebritis

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Cerebritis

Drug clinical trials:

Search ClinicalTrials for Cerebritis

Search NIH Clinical Center for Cerebritis

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Genetic Tests for Cerebritis

Anatomical Context for Cerebritis

Sources:
³²MalaCards
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MalaCards organs/tissues related to Cerebritis:

³²

Brain, Cortex, Endothelial, Testes, Bone, Heart, Liver, Pituitary, T cells, Smooth muscle, B cells, Kidney, Bone marrow, Spinal cord, Skin, Thyroid, Cerebellum, Eye, Temporal lobe, Monocytes, Hypothalamus, Thalamus, Retina, Lung, Pineal, Skeletal muscle, Colon, Globus pallidus, Amygdala, Tongue, Spleen, Whole blood, Breast, Pons, Caudate nucleus, Prefrontal cortex, Olfactory bulb, Myeloid, Nk cells, Parietal lobe, Fetal brain, Occipital lobe, Ovary, Dorsal root ganglion, Lymph node, Salivary gland, Adrenal gland, Prostate, Cingulate cortex, Trigeminal ganglion

Animal Models for Cerebritis or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Cerebritis:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal phenotype	MP:0002873	12.3	CCM2, PDCD10, APP, KNDC1, RMDN3, NOTCH3
2	cardiovascular system phenotype	MP:0005385	12.3	CCM2L, CCM2, PDCD10, CST3, BAP1, KRIT1
3	muscle phenotype	MP:0005369	12.2	NOTCH3, CCM2L, CCM2, PDCD10, CST3, APP

Publications for Cerebritis

Sources:
⁵⁰PubMed
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Articles related to Cerebritis:

(show top 50) (show all 12038)

id	Title	Authors	Year
1	Modulation of cerebral malaria by curcumin as an adjunctive therapy. (23906771)	Jain K.... Gowthamarajan K.	2013
2	Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein. (24252347)	Rangel A.... Chesebro B.	2013
3	Gait patterns in twins with cerebral palsy: similarities and development over time after multilevel surgery. (23475009)	van Drongelen S.... Wolf S.I.	2013
4	Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus. (23266514)	Fisher O.S.... Boggon T.J.	2013
5	A case of cerebral sinus venous thrombosis resulting in mortality in severe preeclamptic pregnant woman. (23509646)	Soydinc H.E.... Cetincakmak M.G.	2013
6	Proteomic analysis of leptomeningeal amyloid fibril extracts of cerebral amyloid angiopathy (CAA) patients with or without corticosteroid therapy. (23879185)	Kametani F.... Ikeda S.	2013
7	Developmental trajectories of social participation in individuals with cerebral palsy: a multi-centre longitudinal study. (24359158)	Tan S.S.... Roebroeck M.E.	2013
8	Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger. (23149557)	O'Donnell M.E.... Anderson S.E.	2013
9	Convergent and Divergent Pathways Decoding Hierarchical Additive Mechanisms in Treating Cerebral Ischemia-Reperfusion Injury. (24351012)	Zhang Y.Y.... Wang Y.Y.	2013
10	One hundred ten days of extracorporeal membrane oxygenation in a young woman with postpartum cerebral venous thrombosis and acute respiratory distress syndrome. (22917818)	Strecker T.... Weyand M.	2012
11	Thunderclap headache as the primary clinical feature of a supratentorial embolic cerebral infarct. (22207313)	Edvardsson B.	2012
12	Neurologic outcomes in retinopathy-negative cerebral malaria survivors. (22914840)	Postels D.G.... Birbeck G.L.	2012
13	Neuronal damage using fluoro-jade B histofluorescence and gliosis in the striatum after various durations of transient cerebral ischemia in gerbils. (22219128)	Ohk T.G.... Cho J.H.	2012
14	Clinical significance of anti-annexin V antibody in acute cerebral ischemia. (21450308)	Lee K.O.... Lee K.Y.	2011
15	Association of ADAMTS13 polymorphism with cerebral malaria. (22168261)	Kraisin S.... Ohashi J.	2011
16	Key compound groups for the neuroprotective effect of roots of Polygonum cuspidatum on transient middle cerebral artery occlusion in Sprague-Dawley rats. (20645208)	Kim J.... Bu Y.	2010
17	Postcarotid endarterectomy improvement in cognition is associated with resolution of crossed cerebellar hypoperfusion and increase in 123I-iomazenil uptake in the cerebral cortex: a SPECT study. (20130400)	Chida K.... Ogawa A.	2010
18	APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging. (20065135)	Thambisetty M.... Resnick S.M.	2010
19	Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation. (20682288)	Ding J.... Wang D.C.	2010
20	Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding. (19967139)	Faille D.... Grau G.E.	2009
21	Effect of seat surface inclination on postural stability and forward reaching efficiency in children with spastic cerebral palsy. (19647395)	Cherng R.J.... Ho C.S.	2009
22	Effects of recombinant human erythropoietin on neuropathic pain and cerebral expressions of cytokines and nuclear factor-kappa B. (19440808)	Jia H.B.... Yang J.J.	2009
23	Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. (18323734)	Collino M.... Fantozzi R.	2008
24	Increased Nepsilon-(carboxymethyl)-lysine levels in cerebral blood vessels of diabetic patients and in a (streptozotocin-treated) rat model of diabetes mellitus. (18426823)	van Deutekom A.W.... Simsek S.	2008
25	Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned. (18695551)	Mack W.J.... Solomon R.A.	2008
26	T2*-weighted MR images of a patient with familial cerebral cavernous malformation. (17443056)	Maeda K.... Sanada M.	2007
27	Plasmodium falciparum delayed cerebellar ataxia and late cerebral malaria. (15937892)	Mohire M.D.	2005
28	Antifungal therapy of experimental cerebral phaeohyphomycosis due to Cladophialophora bantiana. (15855484)	Al-Abdely H.M.... Graybill J.R.	2005
29	Expression of phosphorylation of N-methyl-D-aspartate receptor subunits during graded hypoxia in the cerebral cortex of newborn piglets. (14631158)	Fritz K.I.... Delivoria-Papadopoulos M.	2004
30	The angiotensin II type 1-receptor blocker candesartan increases cerebral blood flow, reduces infarct size, and improves neurologic outcome after transient cerebral ischemia in rats. (15087716)	Engelhorn T.... Schulz R.	2004
31	Resuscitation with 100% O2 increases cerebral injury in hypoxemic piglets. (15347772)	Munkeby B.H.... Saugstad O.D.	2004
32	Haematopoietic stem cell transplantation in 12 patients with cerebral X-linked adrenoleukodystrophy. (12486501)	Baumann M.... Hanefeld F.	2003
33	Cerebral vascular abnormalities in a murine model of hereditary hemorrhagic telangiectasia. (12624308)	Satomi J.... Letarte M.	2003
34	Nestin and small heat shock protein expression on reactive astrocytes and endothelial cells in cerebral abscess. (12354635)	Ha Y.... Kim T.S.	2002
35	T-786C polymorphism in endothelial NO synthase gene affects cerebral circulation in smokers: possible gene-environmental interaction. (11950698)	Nasreen S.... Kobayashi S.	2002
36	Improved neuroprotection with hypothermia delayed by 6 hours following cerebral hypoxia-ischemia in the 14-day-old rat. (11756634)	Taylor D.L.... Edwards A.D.	2002
37	Functional involvement of cerebral diazepam binding inhibitor (DBI) in the establishment of drug dependence]. (11288485)	Katsura M.	2001
38	Actions of Ginkgo Biloba related to potential utility for the treatment of conditions involving cerebral hypoxia. (10983836)	Logani S.... Raffa R.B.	2000
39	Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy. (10818500)	Greenberg S.M.... Rebeck G.W.	2000
40	Interactions between vasoconstrictors in isolated human cerebral arteries. (9248594)	Hempelmann R.G.... Ziegler A.	1997
41	Dyskinetic cerebral palsy and birth asphyxia. (8157150)	Rosenbloom L.	1994
42	Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease. (7515758)	Eikelenboom P.... Rozemuller J.M.	1994
43	Glutamate increases tau phosphorylation in primary neuronal cultures from fetal rat cerebral cortex. (7914466)	Sindou P.... Hugon J.	1994
44	Long-term observations in gerbil brain following transient cerebral ischemia: autoradiographic and histological study. (8272028)	Araki T.... Kogure K.	1993
45	Effects of indeloxazine on hippocampal CA1 pyramidal cell damage following transient cerebral ischemia in the gerbil. (8474628)	Kano T.... Tsubokawa T.	1993
46	Primary cerebral neuroblastoma. (6716155)	Zimman H.M.	1984
47	DEM and cerebral arteriosclerosis. (6875159)	Cox S.S.	1983
48	Cerebral gigantism. Review of the literature and report of one case]. (12259613)	Maes G.... Leutenegger M.	1976
49	Cerebral medulloepithelioma. Case report. (6065130)	Van Epps R.R.... McCormick W.F.	1967
50	Misinterpretation of mirror image of self in presenile cerebral atrophy. (18881936)	HEMPHILL R.E.	1948

Genes related to Cerebritis

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Cerebritis:

(show top 50) (show all 4399)

id	Symbol	Description	Score	Implication
1	APP	amyloid beta (A4) precursor protein	20.00	GeneCards inferred : Publications, Expression, Disorders, Gene name, Summaries (show sections)
2	PDCD10	programmed cell death 10	20.00	GeneCards inferred : Publications, Expression, Summaries, Disorders, Gene name (show sections)
3	CCM2	cerebral cavernous malformation 2	19.99	GeneCards inferred : Publications, Proteins, Orthologs, Domains & Families, Disorders, Gene name, Summaries (show sections)
4	KRIT1	KRIT1, ankyrin repeat containing	19.99	GeneCards inferred : Publications, Disorders, Gene name, Summaries (show sections)
5	BAP1	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	19.98	GeneCards inferred : Orthologs, Disorders, Gene name (show sections)
6	PGBD1	piggyBac transposable element derived 1	19.98	GeneCards inferred : Disorders, Gene name (show sections)
7	CST3	cystatin C	19.98	GeneCards inferred : Publications, Expression, Disorders, Gene name, Orthologs (show sections)
8	NOTCH3	notch 3	19.97	GeneCards inferred : Publications, Expression, Disorders, Summaries (show sections)
9	SLC25A12	solute carrier family 25 (aspartate/glutamate carrier), member 12	19.97	GeneCards inferred : Expression, Publications, Disorders, Summaries (show sections)
10	DEL7Q11.23	Chromosome 7q11.23 deletion syndrome, distal, 1.2Mb	19.96	GeneCards inferred : Publications, Disorders (show sections)
11	CERCAM	cerebral endothelial cell adhesion molecule	19.96	GeneCards inferred : Proteins, Orthologs, Domains & Families, Publications, Disorders, Gene name (show sections)
12	CA10	carbonic anhydrase X	19.95	GeneCards inferred : Expression, Disorders, Gene name (show sections)
13	RRP8	ribosomal RNA processing 8, methyltransferase, homolog (yeast)	19.95	GeneCards inferred : Disorders, Gene name (show sections)
14	RMDN3	regulator of microtubule dynamics 3	19.94	GeneCards inferred : Expression, Gene name, Disorders (show sections)
15	SEPT4	septin 4	19.94	GeneCards inferred : Disorders, Gene name (show sections)
16	TMCC2	transmembrane and coiled-coil domain family 2	19.93	GeneCards inferred : Disorders, Gene name (show sections)
17	ITM2C	integral membrane protein 2C	19.93	GeneCards inferred : Expressions, Disorders, Gene name (show sections)
18	KNDC1	kinase non-catalytic C-lobe domain (KIND) containing 1	19.93	GeneCards inferred : Expressions, Gene name, Disorders (show sections)
19	TSC22D1	TSC22 domain family, member 1	19.92	GeneCards inferred : Expression, Disorders, Gene name (show sections)
20	CCM2L	cerebral cavernous malformation 2-like	19.92	GeneCards inferred : Orthologs, Domains & Families, Disorders, Gene name, Proteins (show sections)
21	KANK1	KN motif and ankyrin repeat domains 1	19.91	GeneCards inferred : Publications, Disorders, Summaries (show sections)
22	FOLR1	folate receptor 1 (adult)	19.91	GeneCards inferred : Publications, Disorders, Summaries (show sections)
23	MEF2C	myocyte enhancer factor 2C	19.90	GeneCards inferred : Expression, Publications, Disorders, Summaries (show sections)
24	ADORA2A	adenosine A2a receptor	19.90	GeneCards inferred : Expression, Publications, Disorders, Summaries (show sections)
25	AP4B1	adaptor-related protein complex 4, beta 1 subunit	19.89	GeneCards inferred : Disorders, Summaries (show sections)
26	HAAO	3-hydroxyanthranilate 3,4-dioxygenase	19.89	GeneCards inferred : Disorders, Summaries (show sections)
27	AP4S1	adaptor-related protein complex 4, sigma 1 subunit	19.88	GeneCards inferred : Disorders, Summaries (show sections)
28	BACE1	beta-site APP-cleaving enzyme 1	19.88	GeneCards inferred : Publications, Disorders, Summaries (show sections)
29	AP4E1	adaptor-related protein complex 4, epsilon 1 subunit	19.88	GeneCards inferred : Publications, Disorders, Summaries (show sections)
30	CD59	CD59 molecule, complement regulatory protein	19.87	GeneCards inferred : Disorders, Summaries (show sections)
31	CPAT1	cerebral palsy, ataxic 1	19.87	GeneCards inferred : Disorders, Publications, Gene name (show sections)
32	GPR119	G protein-coupled receptor 119	19.86	GeneCards inferred : Disorders, Summaries (show sections)
33	AKAP5	A kinase (PRKA) anchor protein 5	19.86	GeneCards inferred : Expression, Expressions, Disorders, Summaries (show sections)
34	RNF103	ring finger protein 103	19.85	GeneCards inferred : Expressions, Disorders, Summaries (show sections)
35	WDR62	WD repeat domain 62	19.85	GeneCards inferred : Pathways & Interactions, Disorders, Functions, Summaries (show sections)
36	KIAA0319	KIAA0319	19.84	GeneCards inferred : Expression, Disorders, Proteins, Functions, Summaries (show sections)
37	OPRK1	opioid receptor, kappa 1	19.84	GeneCards inferred : Expression, Disorders, Summaries (show sections)
38	CD200R1	CD200 receptor 1	19.83	GeneCards inferred : Disorders, Summaries (show sections)
39	MINK1	misshapen-like kinase 1	19.83	GeneCards inferred : Publications, Disorders, Summaries (show sections)
40	AHSG	alpha-2-HS-glycoprotein	19.83	GeneCards inferred : Disorders, Summaries (show sections)
41	HCRTR2	hypocretin (orexin) receptor 2	19.82	GeneCards inferred : Disorders, Summaries (show sections)
42	DAB1	Dab, reelin signal transducer, homolog 1 (Drosophila)	19.82	GeneCards inferred : Expression, Publications, Pathways & Interactions, Disorders, Summaries (show sections)
43	FGF14	fibroblast growth factor 14	19.81	GeneCards inferred : Disorders, Summaries (show sections)
44	FAM127A	family with sequence similarity 127, member A	19.81	GeneCards inferred : Gene name, Disorders (show sections)
45	CCCSX	Cerebral-cerebellar-coloboma syndrome, X-linked	19.80	GeneCards inferred : Disorders, Gene name (show sections)
46	CDNF	cerebral dopamine neurotrophic factor	19.80	GeneCards inferred : Proteins, Orthologs, Domains & Families, Publications, Disorders, Gene name (show sections)
47	PLAT	plasminogen activator, tissue	19.79	GeneCards inferred : Publications, Disorders (show sections)
48	APOE	apolipoprotein E	19.79	GeneCards inferred : Publications, Expression, Disorders (show sections)
49	APOH	apolipoprotein H (beta-2-glycoprotein I)	19.78	GeneCards inferred : Publications, Disorders (show sections)
50	NOS2	nitric oxide synthase 2, inducible	19.78	GeneCards inferred : Publications, Disorders (show sections)