MCID: CRB009
MIFTS: 46

Cerebritis malady

Summaries for Cerebritis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Cerebritis is an infection of the brain that normally leads to the formation of an abscess within the... more...

MalaCards: Cerebritis is related to cerebral cavernous malformation and cadasil. An important gene associated with Cerebritis is APP (amyloid beta (A4) precursor protein), and among its related pathways is A-beta Plaque Formation & APP Metabolism . The compound methionine sulfoxide have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and bone marrow, and related mouse phenotypes are normal and cardiovascular system.

Aliases & Classifications for Cerebritis

Sources:
8Disease Ontology, 61UMLS, 40NCIt
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Aliases & Descriptions:

cerebritis 8 61


External Ids:

Disease Ontology8 DOID:3431
NCIt40 C27199

Related Diseases for Cerebritis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cerebritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1595)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral cavernous malformation31.1KRIT1, PDCD10, CCM2
2cadasil31.0NOTCH3
3alzheimer's disease30.8NOTCH3, APP, CST3
4stroke, ischemic30.8CCM2, KRIT1, NOTCH3
5vascular disease30.7KRIT1, PDCD10, CCM2
6hemorrhage, intracerebral30.6CST3, APP, KRIT1
7vascular dementia30.5NOTCH3
8cerebral cavernous malformation, familial30.5KRIT1, PDCD10, CCM2
9binswanger's disease30.2APP, NOTCH3
10cerebral cavernous malformations-130.1KRIT1
11stroke, hemorrhagic30.1CCM2, APP
12klippel-trenaunay syndrome30.0KRIT1, PDCD10, CCM2
13familial cerebral cavernous malformation 229.7CCM2
14creutzfeldt-jakob syndrome29.4APP, CST3
15cerebral artery occlusion11.0
16cerebral malaria11.0
17cerebral amyloid angiopathy11.0
18cerebral aneurysms11.0
19spastic cerebral palsy10.9
20transient cerebral ischemia10.9
21cerebral atrophy10.9
22venous thrombosis10.8
23cerebral hypoxia10.8
24hypoxia10.8
25middle cerebral artery infarction10.7
26brain ischemia10.7
27cerebral atherosclerosis10.7
28cavernous malformation10.7
29cerebral lymphoma10.7
30atherosclerosis10.7
31arteriovenous malformation10.6
32cerebral arteriosclerosis10.6
33carotid artery occlusion10.6
34arteriosclerosis10.6
35n syndrome10.6
36amyloidosis cerebral10.6
37reversible cerebral vasoconstriction syndrome10.6
38moyamoya disease10.6
39brain edema10.6
40brain injury10.6
41amyloidosis10.6
42gigantism10.5
43spasticity10.5
44vasculitis10.5
45hereditary amyloidosis10.5
46cerebral sinovenous thrombosis10.5
47phaeohyphomycosis10.5
48adrenoleukodystrophy10.5
49cerebral arteritis10.5
50traumatic brain injury10.5

Graphical network of the top 20 diseases related to Cerebritis:



Diseases related to cerebritis

Clinical Features for Cerebritis

Drugs & Therapeutics for Cerebritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cerebritis

Drug clinical trials:

Search ClinicalTrials for Cerebritis

Search NIH Clinical Center for Cerebritis

Search CenterWatch for Cerebritis

Genetic Tests for Cerebritis

Anatomical Context for Cerebritis

Sources:
33MalaCards
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MalaCards organs/tissues related to Cerebritis:

33
Skin, Brain, Bone marrow, Heart, B cells, Globus pallidus

Animal Models for Cerebritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Cerebritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287312.3CCM2, PDCD10, APP, KNDC1, RMDN3, NOTCH3
2MP:000538512.3CCM2L, CCM2, PDCD10, CST3, BAP1, KRIT1
3MP:000536912.2NOTCH3, CCM2L, CCM2, PDCD10, CST3, APP

Publications for Cerebritis

Sources:
51PubMed
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Articles related to Cerebritis:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Immunocompetent young man with cerebral abscess and cortical venous infarction mimicking cerebritis caused by Gemella morbillorum. (23355562)
2013
2
Pseudomonas aeruginosa retro-orbital abscess and cerebritis leading to a diagnosis of interleukin-1 receptor-associated kinase-4 deficiency. (24183992)
2013
3
Delayed cerebritis after bilateral stereotactic implantation of globus pallidus interna electrodes for treatment of dystonia. (23378545)
2013
4
Systemic lupus erythematosus (SLE) cerebritis versus Listeria monocytogenes meningoencephalitis in a patient with systemic lupus erythematosus on chronic corticosteroid therapy: the diagnostic importance of cerebrospinal fluid (CSF) of lactic acid levels. (22177759)
2012
5
Periodic lateralized epileptiform discharges in neuropsychiatric lupus: association with cerebritis in magnetic resonance imaging and resolution after intravenous immunoglobulin. (20133346)
2010
6
Lupus activation with cerebritis following pegylated interferon in a hemodialysis patient. (19776782)
2009
7
Lupus cerebritis after visiting a tanning salon. (20001946)
2009
8
Fatal cerebritis and brain abscesses following a nontraumatic subdural hematoma in a chronic hemodialyzed patient. (19090864)
2008
9
Absence of functional alternative complement pathway alleviates lupus cerebritis. (17523212)
2007
10
Perfusion MR imaging and proton MR spectroscopic imaging in differentiating necrotizing cerebritis from glioblastoma multiforme. (17275620)
2007
11
Listeria monocytogenes skin infection with cerebritis and haemophagocytosis syndrome in a bone marrow transplant recipient. (15845437)
2005
12
Moxifloxacin in experimental Streptococcus pneumoniae cerebritis and meningitis. (16159084)
2005
13
Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. (16339572)
2005
14
Streptococcus constellatus causing myocardial abscess complicated by cerebritis. (15060690)
2004
15
Successful treatment of disseminated cerebritis complicating methicillin-resistant Staphylococcus aureus Endocarditis unresponsive to vancomycin therapy with linezolid. (15119370)
2004
16
Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. (14636948)
2003
17
The efficacy of trovafloxacin versus ceftriaxone in the treatment of experimental brain abscess/cerebritis in the rat. (12888116)
2003
18
Diffusion-weighted imaging of cerebritis. (12812934)
2003
19
Lupus cerebritis: a case study. (12197258)
2002
20
Non-serogroup O:1 Vibrio cholerae bacteremia and cerebritis. (11264049)
2001
21
Encephalitis, cerebritis, and brain abscess: pathophysiology and imaging findings. (10775955)
2000
22
Toxoplasma infection in systemic lupus erythematosus mimicking lupus cerebritis. (10377932)
1999
23
Successful treatment of systemic lupus erythematosus cerebritis with intravenous immunoglobulin. (10357127)
1999
24
Meningitis, vasculitis, and cerebritis caused by CNS histoplasmosis: radiologic-pathologic correlation. (8571874)
1996
25
Cerebritis due to Listeria monocytogenes: CT and MR findings. (8797977)
1996
26
Sjogren's cerebritis complicated by subarachnoid hemorrhage and bilateral superior cerebellar artery occlusion: case report. (7701423)
1995
27
Blood-brain barrier permeability in staphylococcal cerebritis and early brain abscess. (8169631)
1994
28
Diffuse pneumocephalus due to Clostridium septicum cerebritis in haemolytic uraemic syndrome: CT demonstration. (8459926)
1993
29
Seizures and cerebritis associated with administration of OKT3. (1930424)
1991
30
Blood-brain barrier permeability in an experimental model of bacterial cerebritis. (1758602)
1991
31
Focal tuberculous cerebritis. (3124563)
1988
32
Clostridium septicum sepsis and cerebritis: a rare complication of the hemolytic-uremic syndrome. (3380585)
1988
33
CT features of early Listeria monocytogenes cerebritis. (3105286)
1987
34
An unusual CT appearance of lupus cerebritis. (3113219)
1987
35
Psychogenic unresponsiveness in a patient with lupus cerebritis. (3945863)
1986
36
Cerebritis preceding cerebral abscess formation: a report of three cases. (3463295)
1986
37
Fungal cerebritis from intravenous drug abuse. (6538221)
1984
38
Changing concepts in the management of otitic intracranial infection: use of computerized axial tomography in early detection and monitoring of cerebritis. (6738268)
1984
39
Cerebritis masquerading as brain abscess: case report. (7110554)
1982
40
The selective value of computed tomography of the brain in cerebritis due to systemic lupus erythematosus. (7161775)
1982
41
Cerebritis due to group B streptococcus. (6761855)
1982
42
Early diagnosis and management of cerebritis in a child. (7360534)
1980
43
Cerebritis due to Clostridium septicum. (7192812)
1980
44
Localized cerebritis following an esthetic rhinoplasty. (92036)
1979
45
Cerebritis in lupus erythematosus. (426422)
1979
46
The physiopathogenetic basis for the angiographic diagnosis of bacterial infections of the brain and its coverings in children. II. Cerebritis and brain abscess. (456111)
1979
47
Scleroderma cerebritis, an unusual manifestation of progressive systemic sclerosis. (1116415)
1975
48
Letter: "Cerebritis". (4414088)
1974
49
Cerebritis, aseptic meningitis and encephalitis. Individual and community implications. (5410113)
1970
50
The surgical management of cerebritis complicating penetrating wounds of the brain. (13070061)
1953

Genetic Variations for Cerebritis

Expression for genes affiliated with Cerebritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebritis

Search GEO for disease gene expression data for Cerebritis.

Pathways for genes affiliated with Cerebritis

Sources:
53R&D Systems
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Pathways related to Cerebritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0APP, CST3

Compounds for genes affiliated with Cerebritis

Sources:
45Novoseek, 11DrugBank, 24HMDB
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Compounds related to Cerebritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1methionine sulfoxide45 11 2413.0KRIT1, APP

GO Terms for genes affiliated with Cerebritis

Sources:
16Gene Ontology
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Molecular functions related to Cerebritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.6TSC22D1, CCM2, PDCD10, CST3, APP, ITM2C
2beta-amyloid bindingGO:00154011.0ITM2C, CST3

Products for genes affiliated with Cerebritis

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Sources for Cerebritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet