Cerebrovascular Accident malady

Wikipedia: A stroke, or cerebrovascular accident (CVA), is the rapid loss of brain function due to disturbance in...⁴⁴ more...

MalaCards: Cerebrovascular Accident is related to sneddon syndrome and antithrombin iii deficiency. An important gene associated with Cerebrovascular Accident is TSPAN10 (tetraspanin 10), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Glioma Invasiveness. The drug pentoxifylline and the compounds glucose and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

cerebrovascular accident 8 43

Diseases related to cerebrovascular accident by text searches and GeneDecks gene sharing:

(show top 50)    (show all 864)

id	Related Disease	Score	Top Affiliating Genes
1	sneddon syndrome	30.7	SERPINC1, APOH, F5, F2
2	antithrombin iii deficiency	30.4	SERPINC1, MTHFR, APOH, F5, F2, F10
3	myocardial infarction	30.3	APOB, APOE, AIF1, ACE, THBD
4	hypertension	30.3	REN, NOS3, ACE, AGT, EPOR
5	protein c deficiency	30.0	SERPINC1, SERPINE1, MTHFR, APOH, F7, F5
6	leukostasis	29.3	SELE, VEGFA, VCAM1, MPO, ICAM1
7	antiphospholipid syndrome	25.3	VWF, SELE, SELP, SERPINC1, SERPINE1, VKORC1
8	hyperhomocysteinemia	22.0	VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
9	atrial fibrillation	21.7	PIK3C2A, REN, VWF, SELE, SELP, SERPINC1
10	cerebral infarction	20.3	COG2, VWF, SELP, SERPINC1, SERPINE1, VEGFA
11	homocysteine	19.5	PIK3C2A, COG2, REN, VWF, SELE, SELP
12	cerebral cavernous malformation, familial	14.0	PDCD10, CCM2, KRIT1
13	klippel-trenaunay syndrome	14.0	PDCD10, SERPINC1, CCM2, NOTCH4, KRIT1
14	venous malformations	13.9	PDCD10, CCM2, KRIT1
15	placental infarction	13.9	SERPINC1, APOH, F5
16	cavernous hemangioma of orbit	13.9	PDCD10, CCM2, PLAT, KRIT1
17	hyperprothrombinemia	13.8	SERPINC1, F2, CPB2
18	vitamin k-dependent clotting factors	13.8	VKORC1, F5, F2, F10
19	prothrombin deficiency	13.8	SERPINC1, APOH, F5, F2
20	factor x deficiency	13.8	F7, F5, F2, F10
21	chronic inflammatory demyelinating polyneuropathy	13.8	CLDN5, AIF1, NGF, GDNF
22	transverse myelitis	13.8	AQP4, APOH, MBP
23	transient cerebral ischemia	13.8	MTHFR, APOH, NOTCH3
24	factor vii deficiency	13.8	SERPINC1, F7, F5, F2, F10, TFPI
25	placental abruption	13.8	SERPINC1, MTHFR, F5
26	mitral valve disease	13.7	SELP, ACE, AGT, NPPA
27	intermediate coronary syndrome	13.7	PIK3C2A, ITGA2B, AMH, TNNT2, PLAT, PLG
28	mitral valve stenosis	13.7	SELP, PPBP, NPPA, NPPB
29	thrombosis	13.7	MTHFR, FGB, F5, F2
30	conn's syndrome	13.7	REN, AGTR2, NPPA, ADM
31	blood platelet disease	13.7	VWF, ITGA2B, GP1BA, F10
32	lymphoblastic lymphoma	13.7	SERPINC1, ZMYM2, ENO2, ICAM1, NOTCH1, NOTCH3
33	basilar artery occlusion	13.7	ITGA2B, PLAT, SLC12A3
34	pre-eclampsia	13.7	NOS3, EDN1, EDNRA, AGT
35	legg-calve-perthes disease	13.7	SERPINC1, SERPINE1, RAB3IL1, F5, THBD
36	askin's tumor	13.7	S100B, ENO2, NGF
37	autoimmune thrombocytopenic purpura	13.7	SELP, ITGA2, ITGA2B, ITGB3
38	blood protein disease	13.7	MTHFR, F5, F2
39	spinal cord infarction	13.7	SERPINC1, MTHFR, APOH, F5, F2
40	cocaine abuse	13.7	PIK3C2A, BDNF, APOH, MBP, NGB, NGF
41	malignant hypertension	13.7	REN, ACE, ADM
42	renovascular hypertension	13.7	REN, ACE, NPPA, ADM
43	vein disease	13.7	SERPINC1, MTHFR, F5, F2
44	temporal lobe epilepsy	13.7	BDNF, AQP4, APOA1, RTN4, GDNF
45	homocysteine plasma level	13.7	SERPINC1, MTHFR, F5, EDN1
46	central neurocytoma	13.7	RBFOX3, S100B, MBP, ENO2, NES
47	adult respiratory distress syndrome	13.6	SELE, PPBP, THBD, CST3
48	branch retinal artery occlusion	13.6	SERPINC1, MTHFR, ERG
49	renal tubular dysgenesis	13.6	REN, ACE, AGT
50	glanzmann's thrombasthenia	13.6	VWF, ITGA2, ITGA2B, ITGB3, GP1BA, F10

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 pentoxifylline

MalaCards organs/tissues related to cerebrovascular accident:

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MGI Mouse Phenotypes related to cerebrovascular accident:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	EDNRA, AMH
2	hematopoietic system phenotype	MP:0005397	10.3	GP1BA, EPOR, ERG, NOTCH1, NOTCH3, TSPAN33
3	embryogenesis phenotype	MP:0005380	10.0	AIFM1, F2, CCM2, LATS2, UBR5, PARP1
4	respiratory system phenotype	MP:0005388	9.6	CPB2, NOTCH3, APOE, AQP4, ITGB3, BDNF
5	craniofacial phenotype	MP:0005382	9.4	PDCD10, TFPI, EDNRA, EDN1, EDA, KRIT1
6	integument phenotype	MP:0010771	9.3	ITGA2, ITGB3, IL4, CCM2, F5, F2
7	renal/urinary system phenotype	MP:0005367	9.0	NOS3, PLG, APOE, AQP4, INS, KCNMA1
8	liver/biliary system phenotype	MP:0005370	8.9	IL6, INS, VEGFA, SERPINC1, PLA2G1B, APOA1
9	immune system phenotype	MP:0005387	8.9	PDCD10, PDE4A, REN, VWF, SELP, MYO5A
10	reproductive system phenotype	MP:0005389	8.4	GDNF, CCL2, IL6, IL4, MMP9, ITGA2B
11	nervous system phenotype	MP:0003631	8.2	EDA, SERPINC1, NGF, KRIT1, EDN1, EDNRA
12	tumorigenesis	MP:0002006	7.7	AMH, ICAM1, CAT, ITGB3, IGF1, CCL2
13	digestive/alimentary phenotype	MP:0005381	7.5	PLAT, BDNF, GDNF, VWF, PLA2G1B, PLG
14	hearing/vestibular/ear phenotype	MP:0005377	7.4	MYO5A, EDN1, IGF1, PARP1, KCNMA1, BDNF
15	skeleton phenotype	MP:0005390	7.2	IL6, INS, MMP9, ITGB3, MTHFR, IGF1
16	adipose tissue phenotype	MP:0005375	7.1	ACE, NOS3, PLA2G1B, PPARG, IGF1, AGT
17	behavior/neurological phenotype	MP:0005386	6.7	CCM2, CCL2, ENO2, INS, F5, AIFM1
18	normal phenotype	MP:0002873	6.5	PPARG, NOTCH1, NOTCH3, NOTCH4, EDNRA, PTGS2
19	growth/size phenotype	MP:0005378	6.4	VCAM1, MYO5A, MYO6, PARP1, BDNF, KCNMA1
20	vision/eye phenotype	MP:0005391	5.7	MBP, PDCD10, NGF, SELE, SELP, SERPINC1
21	muscle phenotype	MP:0005369	5.4	REN, PDCD10, VEGFA, MYO5A, NOS3, PLAT
22	mortality/aging	MP:0010768	4.5	SERPINE1, VEGFA, VCAM1, MYO5A, MYO6, CLDN5
23	cellular phenotype	MP:0005384	3.9	AGTR2, ITGB3, AIFM1, ERG, PTGS2, PPARG
24	cardiovascular system phenotype	MP:0005385	2.7	CCM2, NOTCH1, NOTCH3, NOTCH4, PDE4D, KRIT1
25	homeostasis/metabolism phenotype	MP:0005376	2.3	AMH, PLG, NOS3, NOTCH1, NOTCH3, NOTCH4

Articles related to cerebrovascular accident:

(show all 15)

id	Title	Authors	Year	Affiliating Genes
1	Determinants and associations of homocysteine and prothrombotic risk factors in Kuwaiti patients with cerebrovascular accident. (18287798)	Mojiminiyi O.A.... El-Muzaini H.	2008	SERPINC1, F5
2	Cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction and cerebrovascular accident. (17402995)	Abraham N.S.... Deswal A.	2007	PTGS2
3	Preventing cerebrovascular accidents during atrial fibrillation (16269996)	Ederhy S.... Cohen A.	2005	F10
4	The identification of multiple thrombophilic risk fa ctors in an infant with cerebrovascular accident (15861329)	Neves J.... Barbot C.	2005	F5
5	Antithrombin III activity in cerebrovascular accidents. (12839349)	Singh V.P.... Dube B.	2003	SERPINC1
6	Antilipemics and prevention of cerebrovascular accidents. Meta-analysis (12822199)	Corvol J.C.... Lechat P.	2003	HMGCR
7	Antioxidant status in cerebrovascular accident. (11437177)	KocatA1rk P.A.... Mutluer N.	2001	CAT
8	Livedo reticularis and cerebrovascular accidents (Sne ddon's syndrome) as a clinical expression of antiphospholipid syndrome. (10343946)	Gantcheva M.... Tsankov N.	1999	APOH
9	Genetic basis of cerebrovascular accidents associated with hypertension. (10389347)	Rubattu S.... Volpe M.	1999	NPPA
10	Could angiotensin II type I receptor antagonists have a superior beneficial effect than that of angiotensin II converting enzyme inhibitors with respect to the risk of cerebrovascular accident? (10486653)	Fournier A.... Andrejak M.	1999	AGTR2
11	Evaluation of serum lipid profile and cardiac enzyme changes in cerebrovascular accidents. (8648151)	Aggarwal S.P.... Kapoor D.K.	1995	PIK3C2A
12	Increase in superoxide dismutase after cerebrovascular accident. (8107520)	Gruener N.... Barak M.	1994	ENO2
13	Familial cerebrovascular accidents due to concomitant hyperhomocysteinemia and protein C deficiency type 1. (8378967)	Franken D.G.... Novakova I.R.	1993	THBD
14	Antithrombin III deficiency and cerebrovascular accidents in young adults. (1430264)	Graham J.A.... Carson P.J.	1992	SERPINC1
15	Radioimmunoassay of serum and CSF myelin basic protein and its application to patients with acute cerebrovascular accident (1284792)	Zhou L.... Lai L.	1992	MBP

Genes related to cerebrovascular accident according to GeneCards:

(show top 50)    (show all 131)

id	Symbol	Description	Score	GeneCards Section Context
1	TSPAN10	tetraspanin 10	11.0
2	WBP2NL	WBP2 N-terminal like	11.0
3	MLX	MAX-like protein X	11.0
4	TSPAN33	tetraspanin 33	11.0
5	KCNJ13	potassium inwardly-rectifying channel, subfamily J, member 13	11.0
6	RAB3IL1	RAB3A interacting protein (rabin3)-like 1	11.0
7	MMD	monocyte to macrophage differentiation-associated	11.0
8	SLC25A40	solute carrier family 25, member 40	11.0
9	NGB	neuroglobin	11.0
10	CLDN5	claudin 5	11.0
11	FBXO17	F-box protein 17	11.0
12	SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	11.0
13	MRS2	MRS2 magnesium homeostasis factor homolog (S. cerevisiae)	11.0
14	INA	internexin neuronal intermediate filament protein, alpha	11.0
15	GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	11.0
16	COPS2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	11.0
17	RRM2	ribonucleotide reductase M2	11.0
18	PTP4A1	protein tyrosine phosphatase type IVA, member 1	11.0
19	GTSE1	G-2 and S-phase expressed 1	11.0
20	DEFA1	defensin, alpha 1	11.0
21	DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide	11.0
22	EEF1A2	eukaryotic translation elongation factor 1 alpha 2	11.0
23	AIF1	allograft inflammatory factor 1	11.0
24	ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1	11.0
25	OCLN	occludin	11.0
26	PLA2G1B	phospholipase A2, group IB (pancreas)	11.0
27	ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	11.0
28	PDCD10	programmed cell death 10	11.0
29	DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	11.0
30	CPB2	carboxypeptidase B2 (plasma)	11.0
31	AGTR2	angiotensin II receptor, type 2	11.0	Publications
32	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	11.0
33	AQP4	aquaporin 4	11.0
34	AMH	anti-Mullerian hormone	11.0
35	GP6	glycoprotein VI (platelet)	11.0
36	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11.0
37	LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	11.0
38	NOTCH3	notch 3	11.0
39	FGB	fibrinogen beta chain	11.0
40	NES	nestin	11.0
41	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0
42	NOTCH4	notch 4	11.0
43	CCM2	cerebral cavernous malformation 2	11.0
44	EPOR	erythropoietin receptor	11.0
45	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0
46	ZMYM2	zinc finger, MYM-type 2	11.0
47	TNNT2	troponin T type 2 (cardiac)	11.0
48	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	11.0
49	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	11.0
50	SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	11.0

Pathways related to cerebrovascular accident according to GeneDecks:

(show all 35)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.9	AGTR2
2	Glioma Invasiveness36	10.6	PLG, PPBP, BDNF, ITGA2B
3	Epithelial Adherens Junctions36	10.6	MYO5A, PTP4A1, NOTCH1, NOTCH3, MYO6, NOTCH4
4	Platelet activation, signaling and aggregation38	10.5	PLG, VWF, FGB, APOA1, PPBP, PRKCH
5	Warfarin Pathway, Pharmacodynamics34	10.5	F7, F2, F10, VKORC1
6	Renin-angiotensin system20	10.5	AGT, ACE, REN, AGTR2
7	Extrinsic Prothrombin Activation Pathway36	10.4	F10, F2, THBD, F5, F7, FGB
8	Blood Coagulation Cascade36	10.4	F5, F10, SERPINC1, F7, FGB, F2
9	Cell adhesion_Integrin inside-out signaling41	10.4	ITGA2, ITGB3, FGB, AGT
10	Intrinsic Prothrombin Activation Pathway36	10.4	F5, SERPINC1, FGB, F10, F2, THBD
11	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	10.4	VWF, F2, GP6, FGB, ITGB3, ITGA2B
12	ECM-receptor interaction20	10.3	GP6, GP1BA, ITGB3, ITGA2B, ITGA2, VWF
13	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.2	KNG1, AGTR2, AGT, NOS3, ACE, REN
14	LDL Oxidation in Atherogenesis36	10.2	MPO, CCL2, VCAM1, ICAM1
15	Development VEGF signaling and activation10	10.0	VCAM1, SELE, PRKCH, ICAM1
16	Endothelin-1 Signaling Pathway36	10.0	IL6, EDNRA, EDN1, PLA2G1B, IL4, PRKCH
17	Angiogenesis3	10.0	MMP9, NOS3, NOTCH1, NOTCH3, NOTCH4, REN
18	African trypanosomiasis20	9.9	VCAM1, SELE, ICAM1, APOA1, IL6
19	Hematopoietic cell lineage20	9.9	EPO, GP1BA, IL6, IL4, ITGB3, ITGA2B
20	Malaria20	9.9	CCL2, IL6, ICAM1, VCAM1, SELP, SELE
21	RhoA Pathway36	9.9	MYO5A, MYO6, ITGA2, ITGA2B, ITGB3, IGF1
22	Selected targets of GCR-alpha10	9.9	INS, THBD, IL4, NOTCH4, CYP2C19, IL6
23	Neuroscience3	9.8	NOTCH3, S100B, ENO2, DCX, NGF, PTGS2
24	Hypertrophic cardiomyopathy (HCM)20	9.8	ITGB3, TNNT2, ACE, IGF1, ITGA2, IL6
25	Complement and coagulation cascades20	9.8	F10, PLAT, PLG, THBD, TFPI, CPB2
26	Blood Coagulation Signaling Pathways37	9.7	GP1BA, GP6, F7, F5, F10, PLG
27	Signaling Involved in Cardiac Hypertrophy36	9.7	ITGA2B, IL6, EPOR, PRKCH, IGF1, EDNRA
28	Transendothelial Migration of Leukocytes36	9.7	ITGA2B, OCLN, PRKCH, PPP1R12A, CCL2, VCAM1
29	Statin Pathway, Pharmacodynamics34	9.5	APOE, HMGCR, APOA1, APOB
30	Development_VEGF signaling and activation41	9.4	VEGFA, SELE, ICAM1, PRKCH, VCAM1
31	Phospholipase-C Pathway36	9.4	PPBP, ITGA2, PPP1R12A, PLA2G1B, PLA2G7, PRKCH
32	Tec Kinases Signaling36	9.3	EPOR, ITGB3, ITGA2B, ITGA2, BDNF, IL6
33	Renin-Angiotensin Pathway36	9.2	CCL2, PPP1R12A, IGF1, AGT, PTGS2, PRKCH
34	Selected targets of HNF110	9.2	APOH, ALB, APOA1, INS, LPA, APOB
35	JAK-STAT Pathway36	9.0	PPBP, EPO, AGTR2, AGT, F2, IGF1

Compounds related to cerebrovascular accident according to GeneDecks:

(show top 50)    (show all 486)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.6	PDE4A, MYO5A, S100B, ITGA2, MLX, GP1BA
2	ascorbic acid32 18	11.3	BDNF, S100B, F10, AIFM1, EPO
3	isoproterenol32 9 9	12.1	PDE4A, KCNMA1, PDE4D, NPPA, ADM
4	ristocetin32	10.0	VWF, SELP, SERPINC1, GP1BA, GP6, F2
5	thromboxane32 18	10.9	PIK3C2A, PDE4A, VWF, SELP, ITGA2, APOH
6	sodium nitroprusside32	9.4	PIK3C2A, PDE4A, REN, VWF, KCNMA1, S100B
7	thromboxane a232 18	10.4	PIK3C2A, PDE4A, VWF, SELP, ITGA2, APOH
8	glutamate32	9.3	VKORC1, KCNMA1, MTHFR, ITGA2, MMP9, INS
9	cerivastatin32 9 9	11.2	PIK3C2A, COG2, REN, SERPINE1, APOA1, APOB
10	polyethylene glycol32	9.1	SELE, SERPINC1, MPO, APOA1, APOE, MBP
11	gemfibrozil32 9 9	11.0	PIK3C2A, COG2, LPA, INS, APOA1, APOB
12	aprotinin32 9 9	11.0	VWF, SELP, SERPINC1, MMP9, GP1BA, IGF1
13	nifedipine32 9 9	10.7	REN, SELE, SERPINE1, BDNF, KCNMA1, MMP9
14	cysteine32	8.7	SELP, VKORC1, LPA, PARP1, MTHFR, S100B
15	h2o232	8.6	PDE4A, VWF, LPA, BDNF, KCNMA1, MPO
16	pge232	8.5	PDE4A, REN, SELE, VCAM1, KCNMA1, APOA1
17	aspartate32	8.5	PIK3C2A, SELP, BDNF, KCNMA1, S100B, MMP9
18	ly29400232	8.5	PIK3C2A, SELE, VEGFA, MMP9, IL4, IL6
19	epinephrine32 9 18 9	11.4	PIK3C2A, PDE4A, REN, SELE, SELP, BDNF
20	ramipril32 9 9	10.4	REN, SERPINE1, INS, ALB, HMGCR, CRP
21	enalapril32 9 9	10.4	REN, SERPINE1, APOA1, ALB, PLAT, EDN1
22	uric acid32 18	9.3	PIK3C2A, SERPINE1, LPA, MTHFR, INS, APOA1
23	warfarin32 34 9 18 9	12.2	PIK3C2A, VWF, SELP, SERPINC1, VKORC1, LPA
24	testosterone32 9 18 9	11.1	PIK3C2A, COG2, SELE, SERPINC1, VCAM1, BDNF
25	pioglitazone32 9 9	10.1	COG2, VEGFA, VCAM1, MMP9, INS, APOA1
26	adenylate32	8.0	PDE4A, VWF, SELE, SELP, SERPINC1, SERPINE1
27	tamoxifen32 34 9 9	10.9	PDE4A, SELE, SERPINC1, VEGFA, VCAM1, BDNF
28	perindopril32 34 9 9	10.8	REN, VWF, SERPINE1, VEGFA, ALB, CRP
29	valsartan32 42 9 9	10.7	REN, SELP, SERPINE1, CCL2, ALB, PPARG
30	phosphatidylcholine32	7.7	SELE, LPA, VCAM1, ITGA2, APOA1, APOB
31	calcium32 9 18 9	10.6	PIK3C2A, COG2, PDE4A, REN, VWF, LPA
32	histamine32 18	8.5	PDE4A, VWF, SELE, SELP, VCAM1, BDNF
33	fibrinogen32	7.2	PIK3C2A, COG2, SELE, SELP, SERPINC1, SERPINE1
34	folate32	7.2	VWF, SELE, SERPINC1, LPA, VCAM1, MTHFR
35	acetylcholine32 9 18 9	10.1	PIK3C2A, PDE4A, VWF, BDNF, KCNMA1, S100B
36	fenofibrate32 9 9	9.1	PIK3C2A, COG2, SELE, SELP, SERPINE1, LPA
37	8-isoprostane32	7.1	SELE, SERPINE1, VCAM1, MPO, MMP9, INS
38	sb 20358032 42	7.8	SELE, VEGFA, VCAM1, PARP1, MMP9, IL6
39	homocysteine32 18	7.8	PIK3C2A, COG2, VWF, SELE, SELP, SERPINC1
40	norepinephrine32 9 18 9	9.7	PIK3C2A, PDE4A, REN, VWF, SELE, SELP
41	rosiglitazone32 9 18 9	9.6	COG2, SELE, SERPINE1, LPA, VCAM1, MMP9
42	aspirin32 34 18	8.6	COG2, PDE4A, VWF, SELE, SELP, SERPINC1
43	lactate32	6.4	PIK3C2A, VWF, SELE, SELP, VCAM1, BDNF
44	alanine32	6.4	PIK3C2A, COG2, VWF, SELE, SERPINC1, VCAM1
45	retinoic acid32 42 18	8.2	PDE4A, VWF, SELP, SERPINE1, VCAM1, PARP1
46	actinomycin d32	5.9	PDE4A, SELE, SERPINE1, VEGFA, LPA, PARP1
47	dexamethasone32 42 34 9 9	9.6	PDE4A, REN, VWF, SELP, SERPINC1, SERPINE1
48	lipid32	5.1	PIK3C2A, COG2, PDE4A, SELE, SERPINE1, LPA
49	cholesterol32 9 18 9	7.8	PIK3C2A, COG2, REN, VWF, SELE, SELP
50	vegf32	3.5	PIK3C2A, PDE4A, REN, VWF, SELE, SELP

Cellular components related to cerebrovascular accident according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule membrane	GO:031092	10.3	SELP, ITGA2B, ITGB3
2	external side of plasma membrane	GO:009897	9.8	ACE, ICAM1, AQP4, IL4, FGB, ITGA2B
3	very-low-density lipoprotein particle	GO:034361	9.5	APOH, APOE, APOB, APOA1
4	secretory granule	GO:030141	9.4	PLAT, PLA2G1B, APOA1, INS, MPO, VEGFA
5	high-density lipoprotein particle	GO:034364	9.3	APOA1, APOE, APOH, PON1
6	endoplasmic reticulum lumen	GO:005788	9.2	INS, APOA1, APOB, F7, F2, F10
7	platelet alpha granule lumen	GO:031093	8.9	VWF, SERPINE1, VEGFA, FGB, IGF1, F5
8	plasma membrane	GO:005886	7.3	KRIT1, NOTCH4, NOTCH3, NOTCH1, NOS3, PLG
9	extracellular region	GO:005576	4.4	GDNF, VWF, APOB, APOE, CCL2, IGF1
10	extracellular space	GO:005615	3.9	IL4, IL6, APOA1, APOB, APOE, APOH

Biological processes related to cerebrovascular accident according to GeneDecks:

(show all 50)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation, extrinsic pathway	GO:007598	10.6	F7, TFPI, F10
2	peptidyl-glutamic acid carboxylation	GO:017187	10.5	VKORC1, F10, F2, F7
3	negative regulation of fibrinolysis	GO:051918	10.5	SERPINE1, APOH, F2, PLG, THBD, CPB2
4	tissue regeneration	GO:042246	10.5	NOTCH3, NOTCH1, INA, SERPINE1
5	low-density lipoprotein particle remodeling	GO:034374	10.4	MPO, PLA2G7, APOB, AGT
6	positive regulation of blood coagulation	GO:030194	10.4	SERPINE1, APOH, F2, F7
7	maternal process involved in parturition	GO:060137	10.4	EDNRA, EDN1, CCL2
8	blood circulation	GO:008015	10.3	ADM, LPA, EPO
9	artery smooth muscle contraction	GO:014824	10.3	EDNRA, EDN1, AGT
10	response to electrical stimulus	GO:051602	10.3	AIF1, DCX, EPO, NGF
11	blood coagulation, intrinsic pathway	GO:007597	10.3	GP1BA, KNG1, F10, F2, APOH, VWF
12	fibrinolysis	GO:042730	10.3	CPB2, PLG, PLAT, F2, GP1BA, SERPINE1
13	positive regulation of vasodilation	GO:045909	10.2	AGTR2, NOS3, INS, ADM
14	positive regulation of leukocyte migration	GO:002687	10.2	SELE, SELP
15	blood vessel remodeling	GO:001974	10.2	NOS3, AGTR2, IGF1, AGT
16	positive regulation of renal sodium excretion	GO:035815	10.1	KNG1, AGT, NPPB, EDN1
17	leukocyte migration	GO:050900	10.1	APOB, SELP, THBD, F2, ITGB3, GP6
18	negative regulation of smooth muscle cell apoptotic process	GO:034392	10.1	IGF1, EDN1, APOH
19	leukocyte cell-cell adhesion	GO:007159	10.0	SELE, SELP, VCAM1, ICAM1
20	response to hyperoxia	GO:055093	10.0	EPO, SERPINE1, MMP9, CAT, NOS3
21	aging	GO:007568	10.0	NOS3, EPO, ADM, RTN4, AGT, EDNRA
22	negative regulation of calcium ion transport	GO:051926	9.9	NOS3, PTGS2, ICAM1
23	positive regulation of nitric oxide biosynthetic process	GO:045429	9.9	AGTR2, INS, ICAM1, EDN1, PTGS2, AIF1
24	response to amino acid stimulus	GO:043200	9.9	CCL2, ICAM1, NOS3, EDN1
25	response to organic cyclic compound	GO:014070	9.9	OCLN, NOS3, PTGS2, NPPB, F7, ENO2
26	negative regulation of platelet activation	GO:010544	9.9	APOE, F2, NOS3, THBD
27	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.8	INS, IL6, AGT, EDA, PLA2G1B, ICAM1
28	negative regulation of lipid storage	GO:010888	9.8	ITGB3, IL6, CRP
29	organ regeneration	GO:031100	9.7	APOH, CCL2, ADM, F7, PPARG, NOTCH1
30	positive regulation of cholesterol esterification	GO:010873	9.7	AGT, APOE, APOA1
31	positive regulation of smooth muscle cell proliferation	GO:048661	9.7	AIF1, PTGS2, IL6, IGF1, NOTCH3, EDN1
32	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.7	INS, IGF1, F2, CAT, AGT, SELP
33	response to glucocorticoid stimulus	GO:051384	9.6	PTGS2, SERPINE1, IL6, CCL2, ADM, PLAT
34	negative regulation of blood coagulation	GO:030195	9.6	KNG1, THBD, EDN1, APOH, APOE, SERPINE1
35	lipoprotein metabolic process	GO:042157	9.4	APOE, APOB, APOA1, LPA, ALB
36	negative regulation of acute inflammatory response	GO:002674	9.3	INS, PPARG, IL4
37	heart development	GO:007507	9.3	EDN1, EDNRA, NPPB, EPOR, NOTCH1, ADM
38	response to lipopolysaccharide	GO:032496	9.3	SELE, SELP, MMP9, PTGS2, APOB, NOTCH1
39	regulation of blood pressure	GO:008217	9.3	NOS3, NPPB, NPPA, AGTR2, ACE, PPARG
40	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	ITGB3, VEGFA, INS, IL6, IGF1, AGT
41	negative regulation of smooth muscle cell proliferation	GO:048662	9.1	NPPB, AIF1, PPARG, NOS3
42	inflammatory response	GO:006954	9.0	AIF1, AGTR2, CRP, PTGS2, CCL2, IL6
43	platelet degranulation	GO:002576	8.9	KNG1, PLG, PPBP, ALB, F5, IGF1
44	anti-apoptosis	GO:006916	8.8	EPO, GDNF, EEF1A2, NOS3, F7, CCL2
45	negative regulation of apoptotic process	GO:043066	8.8	PDCD10, ALB, AIF1, SERPINE1, VEGFA, INS
46	positive regulation of cell proliferation	GO:008284	8.5	ADM, PDCD10, VEGFA, INS, IGF1, F2
47	response to hypoxia	GO:001666	8.4	VEGFA, EDN1, KCNMA1, CAT, MMP9, CCL2
48	platelet activation	GO:030168	8.4	PRKCH, ITGA2B, VEGFA, SERPINE1, VWF, SELP
49	response to drug	GO:042493	8.1	PTGS2, AMH, NES, CPB2, NPPB, BDNF
50	blood coagulation	GO:007596	7.8	KNG1, CPB2, PRKCH, TFPI, THBD, NOS3

Molecular functions related to cerebrovascular accident according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	eukaryotic cell surface binding	GO:043499	10.1	SELP, FGB, APOH, EPO
2	glycoprotein binding	GO:001948	10.1	SELP, FBXO17, APOH, F7, VWF
3	protease binding	GO:002020	9.9	INS, SERPINC1, CST3, MBP, SERPINE1
4	cell surface binding	GO:043498	9.7	PLG, PLA2G1B, ICAM1, VEGFA
5	receptor binding	GO:005102	9.4	EDA, CCL2, NPPB, NPPA, PLA2G1B, CAT
6	hormone activity	GO:005179	9.1	EPO, ADM, NPPB, NPPA, AGT, EDN1
7	enzyme binding	GO:019899	9.1	ALOX5AP, PRKCH, NOTCH3, NOTCH1, CYP2C19, PPARG
8	heparin binding	GO:008201	8.9	VEGFA, SERPINC1, LPA, MPO, APOB, APOE
9	growth factor activity	GO:008083	8.8	IL4, IL6, IGF1, AMH, F2, PPBP
10	protein homodimerization activity	GO:042803	8.3	S100B, MLX, APOE, HMGCR, ENO2, ALOX5AP
11	protein binding	GO:005515	3.5	GP1BA, SCAI, KCNMA1, PARP1, RAB3IL1, MYO6