Cerebrovascular Disease malady

Wikipedia: Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels...⁴⁴ more...

MalaCards: Cerebrovascular Disease, also known as cerebrovascular disorders, is related to vascular dementia and myocardial infarction. An important gene associated with Cerebrovascular Disease is SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3), and among its related pathways are Statin Pathway, Pharmacodynamics and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds glucose and lovastatin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and thyroid, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Descriptions:

cerebrovascular disease 6 7 32 cerebrovascular disorders 43

cerebrovascular disorder 6

Diseases related to cerebrovascular disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 952)

id	Related Disease	Score	Top Affiliating Genes
1	vascular dementia	31.5	SERPINA3, VEGFA, LPA, MTHFR, APOE, APP
2	myocardial infarction	31.3	OLR1, LTA, ACE, THBD
3	cadasil	29.9	IL6, ALOX5AP, NOS3, PDE4D
4	memory impairment	29.5	BACE1, APOE, APP, MAPT, TRH, ACHE
5	lewy body dementia	29.3	APOE, APP, MAPT, ACHE, SLC6A3
6	thrombosis	29.2	MTHFR, FGB, F8, F5, F2
7	hypertension	28.8	REN, GNB3, NOS3, ACE, AGT, AGTR1
8	portal vein thrombosis	28.3	REN, SELP, SERPINC1, SERPINE1, MTHFR, APOH
9	moyamoya disease	27.9	RETN, SERPINC1, MMP9, F2, NOS3, ACTA2
10	thromboembolism	27.4	VWF, SELP, SERPINC1, SERPINE1, SERPINA3, MTHFR
11	sensorineural hearing loss	27.3	SERPINC1, SERPINE1, MTHFR, MTR, ITGB3, GSTM1
12	thrombophilia	27.2	VWF, SELE, SELP, SERPINC1, SERPINE1, MTRR
13	cerebral aneurysms	26.8	REN, SELP, MMP9, IL6, APOE, TNF
14	carotid stenosis	26.4	COG2, REN, SELP, LPA, LPL, MTHFR
15	hearing loss	26.3	SERPINC1, SERPINE1, MTHFR, MTR, ITGB3, GSTM1
16	intracranial aneurysm	25.8	REN, SERPINE1, SERPINA3, VEGFA, LPA, MTHFR
17	sickle cell anemia	25.1	VWF, SELE, SELL, SELP, VCAM1, LDLR
18	dementia	24.9	VWF, SELP, SERPINC1, SERPINE1, SERPINA3, VIP
19	type 2 diabetes mellitus	24.6	COG2, RECK, RETN, VWF, SELE, SELL
20	systemic lupus erythematosus	24.1	RECK, VWF, SELE, VIP, VCAM1, LCN2
21	aldosteronism	23.2	REN, RETN, SERPINE1, VIP, VEGFA, CETP
22	homocysteine	21.8	COG2, REN, RETN, VWF, SELE, SELP
23	noma	21.4	REN, SELL, VEGFA, LEP, UCP2, MMP9
24	brain injury	21.2	RETN, VWF, SELP, SERPINC1, SERPINE1, VEGFA
25	sickle cell disease	21.1	VWF, SELE, SELL, SELP, SERPINE1, VEGFA
26	alzheimer's disease	20.9	COG2, RECK, REN, SELL, SELP, SELPLG
27	hypercholesterolemia	19.7	COG2, RETN, VWF, SELE, SELP, SELPLG
28	pneumonia	18.8	COG2, SELE, SELL, SERPINC1, SERPINE1, VEGFA
29	diabetes mellitus	18.7	COG2, RECK, REN, RETN, VWF, SELE
30	insulin resistance	18.5	COG2, REN, RETN, VWF, PCLO, SELE
31	anemia	18.3	REN, VWF, SELE, SELL, SELP, SERPINC1
32	lupus erythematosus	17.2	COG2, RECK, RETN, VWF, SELE, SELL
33	acute myocardial infarction	17.2	COG2, REN, RETN, VWF, SELE, SELL
34	cerebritis	16.7	COG2, REN, VWF, SELE, SELP, SERPINC1
35	neuronitis	16.6	RECK, REN, RETN, VWF, PCLO, SELE
36	thyroiditis	15.8	COG2, RECK, REN, RETN, VWF, SELE
37	obesity	15.8	COG2, RECK, REN, RETN, VWF, SELE
38	cetp deficiency	14.1	LPL, LDLR, CETP, APOA1, APOB, APOE
39	familial combined hyperlipidemia	14.1	APOA1, APOB, APOE, HMGCR
40	transient cerebral ischemia	14.1	LCN2, MTHFR, FGA, APOH, NOTCH3
41	defective apolipoprotein b-100	14.1	LDLR, APOB, APOE, HMGCR
42	neural tube defect	14.1	UCP2, MTRR, MTHFR, MTR, CBS, ACHE
43	familial hypertriglyceridemia	14.1	LPL, APOA1, APOB, APOE
44	hereditary angioedema	14.0	CETP, APP, F5, F12, C4B, PON1
45	hyperlipidemia type 3	14.0	COG2, LPA, LPL, LDLR, CETP, APOA1
46	amyloid tumor	14.0	SERPINA3, BACE1, APOE, APP, MAPT, CTSG
47	familial hypercholesterolemia	14.0	COG2, LPA, LPL, LDLR, CETP, APOA1
48	thiamine-responsive megaloblastic anemia syndrome	14.0	MTRR, MTHFR, MTR, TCN2
49	cherubism	14.0	LPL, LDLR, CETP, APOB
50	hypoalphalipoproteinemia	14.0	LPA, LPL, LDLR, CETP, APOA1, APOB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cerebrovascular disease:

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MGI Mouse Phenotypes related to cerebrovascular disease:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	ACHE, LTC4S, NOTCH3, CYBA, F13A1, CBS
2	hematopoietic system phenotype	MP:0005397	10.4	LCN2, ITGA2, ITGA2B, GPI, GP1BA, F13A1
3	endocrine/exocrine gland phenotype	MP:0005379	10.3	ACD, LTA, TERF1, TRH, LDLR, SELL
4	pigmentation phenotype	MP:0001186	10.0	ACD, TERF2IP, TERF1, TERC, APOE, APOB
5	embryogenesis phenotype	MP:0005380	9.9	TERF1, KRIT1, G6PD, DPAGT1, PROCR, POT1
6	integument phenotype	MP:0010771	9.7	ITGB3, FGA, IL4, APP, MAPT, F5
7	other phenotype	MP:0005395	9.4	MAPT, SPP1, NOS3, COL4A1, ADM, APP
8	renal/urinary system phenotype	MP:0005367	9.4	SELPLG, INS, APOE, FABP2, MAPT, CBS
9	nervous system phenotype	MP:0003631	8.8	RECK, REN, VWF, PCLO, SELP, SERPINC1
10	liver/biliary system phenotype	MP:0005370	8.7	ADM, AGT, NOS3, RECK, RETN, SERPINC1
11	skeleton phenotype	MP:0005390	8.3	IL6, ALOX5AP, TERC, TERT, SPP1, PLAT
12	digestive/alimentary phenotype	MP:0005381	8.2	F2, TERC, TERF1, TERT, PLAT, NOS3
13	no phenotypic analysis	MP:0003012	8.1	TNKS, TERF1, TERF2IP, PDE4D, ACHE, AGER
14	adipose tissue phenotype	MP:0005375	8.0	TNKS, TNKS2, TERC, NOS3, ACE, ACHE
15	normal phenotype	MP:0002873	7.6	OLR1, TERT, TERF1, TEP1, HMGCR, F12
16	immune system phenotype	MP:0005387	7.0	MS4A2, ITGA2B, IL6, APOA1, APOA4, MBP
17	tumorigenesis	MP:0002006	6.7	TERF1, TERT, SPP1, CTSG, NOTCH3, ACE
18	behavior/neurological phenotype	MP:0005386	6.4	NOS3, PLP1, PLAT, NR3C2, SPP1, CYBA
19	reproductive system phenotype	MP:0005389	6.3	REN, VIP, VEGFA, LEP, ITGA2B, MMP9
20	growth/size phenotype	MP:0005378	5.9	TERF1, PROCR, CX3CR1, SLC6A3, ADIPOQ, PRKCH
21	vision/eye phenotype	MP:0005391	5.8	SELE, SELP, SERPINC1, VEGFA, LEP, LDLR
22	mortality/aging	MP:0010768	5.4	SERPINC1, SERPINE1, VEGFA, LPL, VCAM1, LEP
23	muscle phenotype	MP:0005369	5.3	ADIPOQ, REN, VEGFA, SPP1, PLAT, NOS3
24	homeostasis/metabolism phenotype	MP:0005376	3.9	AGT, THBD, PRKCH, PROCR, CX3CR1, SOD3
25	cellular phenotype	MP:0005384	3.2	TNF, THBD, PRKCH, CX3CR1, POT1, PON1
26	cardiovascular system phenotype	MP:0005385	3.2	APOA4, PLAT, NOS3, NOTCH3, COL4A1, PDE4D

Articles related to cerebrovascular disease:

(show top 50)    (show all 158)

id	Title	Authors	Year	Affiliating Genes
1	Association between the -1562 C/T MMP-9 polymorphism and cerebrovascular disease in a Polish population. (20827608)	Szczudlik P.... BorratyA8ska A.	2010	MMP9
2	A randomized controlled trial of rivastigmine in pati ents with cognitive impairment no dementia because of cerebrovascular disease. (19951274)	Narasimhalu K.... Tan E.K.	2010	ACHE
3	Treatment with galantamine and time to nursing home placement in Alzheimer's disease patients with and without cerebrovascular disease. (18985627)	Feldman H.H.... Kavanagh S.	2009	ACHE
4	Cerebrovascular disease related to COL4A1 mutations i n HANAC syndrome. (19949034)	Alamowitch S.... Ronco P.	2009	COL4A1
5	C-reactive protein and risk of ischaemic vascular an d cerebrovascular disease--secondary publication (19492468)	Zacho J.... Nordestgaard B.G.	2009	CRP
6	Glucose 6 phosphate dehydrogenase deficiency is not a ssociated with cerebrovascular disease in children with sickle cell anemia. (19608759)	Rees D.C.... Thein S.L.	2009	G6PD
7	Measuring holotranscobalamin II, an early indicator of negative vitamin B12 balance, by radioimmunoassay in patients with ischemic cerebrovascular disease. (17992530)	Serefhanoglu S.... Kuku I.	2008	TCN2
8	Acute myocardial infarction, ischemic cerebrovascular disease and variceal bleeding due to portal vein thrombosis in a patient with hereditary thrombophilia. (18388507)	Baran B.... Dolar E.	2008	F5
9	The C242T polymorphism of the NAD(P)H oxidase p22phox subunit is associated with an enhanced risk for cerebrovascular disease at a young age. (18799874)	Genius J.... Lichy C.	2008	CYBA
10	Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. (17568241)	Campbell D.J.... Woodward M.	2007	CRP
11	No association of the -105 promoter polymorphism of the selenoprotein S encoding gene SEPS1 with cerebrovascular disease. (17880573)	Hyrenbach S.... Grond-Ginsbach C.	2007	VIMP
12	PDE4D and ALOX5AP genetic variants and risk for Ischemic Cerebrovascular Disease in Sweden. (17655870)	Kostulas K.... Hillert J.	2007	ALOX5AP, PDE4D
13	Polymorphism -238 G/A of tumor necrosis factor alpha gene promoter is a genetic risk factor for ischemic cerebrovascular disease. (17873294)	Llamas Sillero P.... Tomas Martinez J.F.	2007	TNF
14	Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily. (16894458)	Bosco P.... Gueant J.L.	2006	MTR, MTHFR, MTRR
15	Cerebrovascular disease in the elderly: lipoprotein metabolism and cognitive decline. (16702784)	Panza F.... Capurso A.	2006	APOE
16	Factor V Leiden mutation in cerebrovascular disease. (16015421)	Buyru N.... Ulutin T.	2005	F5
17	Hypoadiponectinemia is associated with ischemic cerebrovascular disease. (15692106)	Chen M.P.... Lee Y.J.	2005	ADIPOQ
18	123I-FP-CIT SPECT imaging of dopamine transporters in patients with cerebrovascular disease and clinical diagnosis of vascular parkinsonism. (15471834)	Lorberboym M.... Lampl Y.	2004	SLC6A3
19	Apolipoprotein E polymorphism in ischemic cerebrovascular diseases and vascular dementia patients in Taiwan. (15084782)	Lin H.F.... Liu C.K.	2004	APOE
20	Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia. (15277612)	DeCarli C.... Jagust W.	2004	APOE
21	The Perindopril Protection Against Recurrent Stroke S tudy (PROGRESS): clinical implications for older patients with cerebrovascular disease. (12641480)	Ratnasabapathy Y.... Anderson C.S.	2003	ACE
22	Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (12871600)	Adams G.T.... Kutlar A.	2003	ICAM1, SERPINE1, ITGA2B
23	Evaluation of the factor V HR2 haplotype as a risk factor for ischemic cerebrovascular disease. (12604422)	Lecumberri R.... Rocha E.	2003	F5
24	Neurological complication due to the drug and the maneuver for the treatment and prevention of cerebrovascular diseases: iatrogenic neurology (15152491)	Takagi S.	2003	HMGCR
25	APOE genotype in cerebrovascular disease and vascular dementia. (12417379)	Frank A.... Barreiro P.	2002	APOE
26	Cerebrovascular disease in type 2 diabetes mellitus. (12577084)	Dalal P.M.... Parab P.V.	2002	FGA
27	Apolipoprotein E epsilon 4 allele frequency in demented and cognitively impaired patients with and without cerebrovascular disease. (12417380)	Traykov L.... Forette F.	2002	APOE
28	Apolipoprotein E gene polymorphism in cerebrovascular disease: a case-control study. (12123486)	Luthra K.... Das N.	2002	APOE
29	Genetic risk factors in young adults with 'cryptogenic' ischemic cerebrovascular disease. (12439143)	Grossmann R.... Schwender S.	2002	CBS, F2, F5
30	Spectrum of antiphospholipid antibodies (aPL) in patients with cerebrovascular disease. (17903828)	Gonzales-Portillo F.... Biller J.	2001	APOH
31	Paraoxonase 1 192 Gln/Arg gene polymorphism and cerebrovascular disease: interaction with type 2 diabetes. (11409295)	Koch M.... Pfohl M.	2001	PON1
32	Analysis of complex segregation in a large family with hereditary cerebrovascular disease in Antioquia, Colombia (11310272)	Lopera F.... Arcos-Burgos M.	2001	NOTCH3
33	Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases. (11557685)	Herrmann S.M.... Paul M.	2001	CTSG
34	Serum cholesteryl ester transfer protein concentrations in healthy Chinese subjects and cardio-cerebrovascular disease patients. (11249918)	Zhuang Y.... Chen G.	2001	CETP
35	Lipoprotein lipase genetic variation and gender-specific ischemic cerebrovascular disease risk. (11127970)	Ordovas J.M.	2000	LPL
36	Polymorphism in the promoter of lipopolysaccharide receptor CD14 and ischemic cerebrovascular disease. (11062291)	Ito D.... Fukuuchi Y.	2000	CD14
37	The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models. (10867209)	Horsburgh K.... Nicoll J.A.	2000	APOE
38	Frequencies of certain complement protein alleles and serum levels of anti-heat-shock protein antibodies in cerebrovascular diseases. (11062289)	Kramer J.... Fust G.	2000	C4B
39	Prothrombotic genetic risk factors in patients with coexisting migraine and ischemic cerebrovascular disease. (11279932)	Iniesta J.A.... Vicente V.	1999	F2, F7, ITGB3
40	Study on relationship between anticardiolipin antibody and cerebrovascular diseases. (12840879)	Liu C.... Tong E.	1999	APOH
41	APOE genotype as a risk factor for ischemic cerebrovascular disease: a meta-analysis. (10522889)	McCarron M.O.... Alberts M.J.	1999	APOE
42	Alterations in neurotransmitter, amino acid and free radical related substances in cerebrospinal fluid in patients with cerebrovascular diseases (10410569)	Egashira T.... Matsumiya T.	1999	ACHE
43	Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma. (9731617)	Markus H.S.... Powell J.F.	1998	NOS3
44	Genetic risk factors and ischaemic cerebrovascular disease: role of common variation of the genes encoding apolipoproteins and angiotensin-converting enzyme. (9667803)	Aalto-SetAolAo K.... Kontula K.	1998	APOE, APOB
45	ACE gene polymorphism as a risk factor for ischemic cerebrovascular disease. (9273825)	Agerholm-Larsen B.... Nordestgaard B.G.	1997	ACE
46	Benzodiazepine receptors in chronic cerebrovascular disease: comparison with blood flow and metabolism. (9374335)	Sasaki M.... Masuda K.	1997	TSPO
47	Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases. (8128507)	Schaarschmidt H.... Reiber H.	1994	ENO2
48	No effect of cloricromen on some coagulation parameters in patients with ischaemic cerebrovascular disease. (7867874)	Orefice G.... Carrieri P.B.	1994	SERPINC1
49	Apo E allele frequencies in Alzheimer's disease, Lewy body dementia, Alzheimer's disease with cerebrovascular disease and vascular dementia. (7841371)	BActard C.... Gauvreau D.	1994	APOE
50	A study of plasma von Willebrand factor concentration in patients with cerebrovascular disease (1499407)	Wang Y.	1992	VWF

Genes related to cerebrovascular disease according to GeneCards:

(show top 50)    (show all 125)

id	Symbol	Description	Score	GeneCards Section Context
1	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
2	NOTCH3	notch 3	11.0	Publications
3	F12	coagulation factor XII (Hageman factor)	11.0	Publications
4	APOE	apolipoprotein E	11.0	Publications
5	SELPLG	selectin P ligand	11.0	Publications
6	CX3CR1	chemokine (C-X3-C motif) receptor 1	11.0	Publications
7	CBS	cystathionine-beta-synthase	11.0	Publications
8	SOD3	superoxide dismutase 3, extracellular	11.0
9	FABP2	fatty acid binding protein 2, intestinal	11.0	Publications
10	TSPO	translocator protein (18kDa)	11.0	Publications
11	TRH	thyrotropin-releasing hormone	11.0	Publications
12	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
13	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	11.0	Publications
14	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
15	RECK	reversion-inducing-cysteine-rich protein with kazal motifs	11.0	Publications
16	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
17	COG2	component of oligomeric golgi complex 2	11.0
18	LPL	lipoprotein lipase	11.0	Publications
19	CST3	cystatin C	11.0
20	KRIT1	KRIT1, ankyrin repeat containing	11.0
21	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications
22	PLAT	plasminogen activator, tissue	11.0	Publications
23	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
24	ADM	adrenomedullin	11.0
25	ACHE	acetylcholinesterase	11.0	Publications
26	BACE1	beta-site APP-cleaving enzyme 1	11.0
27	PON1	paraoxonase 1	11.0	Publications
28	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
29	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
30	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0	Publications
31	AGTR1	angiotensin II receptor, type 1	11.0	Publications
32	APP	amyloid beta (A4) precursor protein	11.0	Publications
33	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
34	LDLR	low density lipoprotein receptor	11.0	Publications
35	APOA1	apolipoprotein A-I	11.0	Publications
36	ACD	adrenocortical dysplasia homolog (mouse)	11.0	Publications
37	DPAGT1	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	11.0	Publications
38	LTC4S	leukotriene C4 synthase	11.0	Publications
39	TCN2	transcobalamin II	11.0	Publications
40	LCN1	lipocalin 1	11.0	Publications
41	TERF2IP	telomeric repeat binding factor 2, interacting protein	11.0	Publications
42	CYBA	cytochrome b-245, alpha polypeptide	11.0	Publications
43	C4B	complement component 4B (Chido blood group)	11.0	Publications
44	TERF2	telomeric repeat binding factor 2	11.0	Publications
45	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0	Publications
46	PROCR	protein C receptor, endothelial	11.0	Publications
47	TEP1	telomerase-associated protein 1	11.0	Publications
48	ALDOA	aldolase A, fructose-bisphosphate	11.0	Publications
49	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0	Publications
50	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	11.0	Publications

Pathways related to cerebrovascular disease according to GeneDecks:

(show top 50)    (show all 51)

id	Pathway	Score	Top Affiliating Genes
1	Statin Pathway, Pharmacodynamics34	10.9	HMGCR, APOE, APOB, APOA4, APOA1, LDLR
2	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics34	10.8	CBS, MTR, MTHFR, MTRR
3	Chromosome Maintenance38	10.7	TERF1, ACD, POT1
4	Renin-angiotensin system20	10.7	AGTR1, AGT, ACE, CTSG, REN
5	ACE Inhibitor Pathway, Pharmacodynamics34	10.6	AGTR1, NR3C2, CTSG
6	LDL-mediated lipid transport38	10.6	LPA, LDLR, CETP
7	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics34	10.6	CBS, GSTM1, MTR, MTHFR, MTRR
8	Cell surface interactions at the vascular wall38	10.5	THBD, OLR1, F2, SELPLG, SELP, SELL
9	Selected targets of C/EBPalpha10	10.5	ADIPOQ, CTSG, APOB, CETP, SERPINC1, RETN
10	Telomere Extension by Telomerase36	10.5	POT1, TERT, TERF2IP, TERF2, TERF1, TNKS2
11	Selected targets of C/EBPbeta10	10.5	SOD3, MBP, APOB, CETP, VWF, RETN
12	Common Pathway38	10.5	SERPINC1, F5, F13A1
13	Cell adhesion_Integrin inside-out signaling41	10.5	AGTR1, AGT, GNB3, FGB, FGA, ITGB3
14	Extrinsic Prothrombin Activation Pathway36	10.5	THBD, F13A1, F12, F2, F5, F7
15	Platelet activation, signaling and aggregation38	10.4	PRKCH, APOA1, FGB, FGA, VWF
16	Cell adhesion Integrin inside-out signaling10	10.4	AGTR1, GNB3, F2, FGB, FGA, ITGB3
17	Telomerase Components in Cell Signaling36	10.4	POT1, PRKCH, TERT, TERF2, TERF1, TEP1
18	Cell adhesion_Plasmin signaling41	10.4	FGA, FGB, F12, PLAT, COL4A1, VEGFA
19	Cell adhesion Plasmin signaling10	10.4	COL4A1, PLAT, F12, FGB, FGA, VEGFA
20	Reelin Pathway (Cajal-Retzius cells)36	10.3	ACTA2, MAPT, APP, APOE, ITGB3, ITGA2B
21	Intrinsic Prothrombin Activation Pathway36	10.3	THBD, COL4A1, F13A1, F12, F2, F5
22	Blood Coagulation Cascade36	10.3	THBD, COL4A1, F13A1, F12, F2, F5
23	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.3	AGTR1, AGT, ACE, NOS3, NR3C2, CTSG
24	ECM-receptor interaction20	10.2	COL4A1, SPP1, GP1BA, ITGB3, ITGA2B, ITGA2
25	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	10.2	COL4A1, GNB3, F2, FGB, FGA, ITGB3
26	Metalloproteases in connective tissue degradation10	10.2	CST3, COL4A1, MBP, FGB, FGA, MMP9
27	Complement and coagulation cascades20	10.1	THBD, VWF, SERPINC1, SERPINE1, FGA, FGB
28	Blood Coagulation Signaling Pathways37	10.1	THBD, SERPINC1, SERPINE1, FGB, GP1BA, F8
29	Angiogenesis3	10.0	ITGB3, MMP9, NOS3, NOTCH3, REN, RECK
30	Selected targets of HNF110	10.0	CRP, F13A1, F8, APOH, APOB, APOA1
31	Adipocytokines & Insulin Signaling37	9.7	ADIPOQ, INS, LEP, RETN
32	Molecular Mechanisms of Cancer36	9.6	CX3CR1, LTA, COL4A1, SPP1, GNB3, IL6
33	Amoebiasis20	9.5	COL4A1, CTSG, IL8, IL6, CD14
34	Hematopoietic cell lineage20	9.2	TNF, GP1BA, IL6, IL4, ITGB3, ITGA2B
35	Immune response_MIF-mediated glucocorticoid regulation41	8.9	TNF, ICAM1, IL8, IL6, VCAM1
36	Immune response MIF-mediated glucocorticoid regulation10	8.9	TNF, ICAM1, IL8, IL6, VCAM1
37	Endothelin-1 Signaling Pathway36	8.9	PRKCH, IL6, IL4, IL10
38	Hypertrophic cardiomyopathy (HCM)20	8.9	ACE, TNF, IL6, ITGB3, ITGA2B, ITGA2
39	Transendothelial Migration of Leukocytes36	8.8	GNB3, CYBA, SPP1, COL4A1, ACTA2, PRKCH
40	ERK Signaling36	8.7	COL4A1, SPP1, IL6, IL4, IL10, ITGA2B
41	Selected targets of GCR-alpha10	8.7	THBD, CYP2C19, IL8, IL6, IL4, INS
42	African trypanosomiasis20	8.7	TNF, ICAM1, APOA1, IL6, IL10, VCAM1
43	Cytokine Network36	8.5	LTA, TNF, IL8, IL6, IL4, IL10
44	Pertussis20	8.5	C4B, TNF, IL8, IL6, IL10, CD14
45	Akt Signaling36	8.4	CX3CR1, LTA, TNF, GNB3, CCR5, IL6
46	Malaria20	8.3	TNF, ICAM1, IL8, IL6, IL10, VCAM1
47	MIF Mediated Glucocorticoid Regulation36	8.1	LTA, TNF, IL8, IL6, IL4, IL10
48	MIF Regulation of Innate Immune Cells36	8.0	LTA, TNF, IL8, IL6, IL4, IL10
49	Tec Kinases Signaling36	8.0	CX3CR1, PRKCH, ACTA2, TNF, GNB3, CCR5
50	Cytokine-cytokine receptor interaction20	7.5	CX3CR1, LTA, TNF, CCR5, IL8, IL6

Compounds related to cerebrovascular disease according to GeneDecks:

(show top 50)    (show all 538)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.7	ITGA2, GPI, GP1BA, ALDOA, TRH, CTSG
2	lovastatin32 42 9 9	13.7	COG2, LPA, LPL, LDLR, BACE1, CETP
3	nadph32 18	11.4	UCP2, FABP2, MAPT, CYP2C19, CYBA, OLR1
4	nicotine32 34 9 9	13.3	SELL, CYP2C19, NR3C2
5	ristocetin32	10.2	RECK, VWF, SELP, SERPINC1, GP1BA, F8
6	gemfibrozil32 9 9	12.1	COG2, LPA, LPL, LDLR, CETP, INS
7	sele32	10.0	SELL, SELP, LPL, LDLR, MTHFR, CETP
8	carbohydrates32	10.0	RECK, SELE, SELL, SELP, SELPLG, VCAM1
9	l-nmma32	10.0	VIP, VCAM1, CCK, HBG2, AGT, AGTR1
10	warfarin32 34 9 18 9	13.9	VWF, SELP, SERPINC1, LPA, MTHFR, FGA
11	vitamin-e32	9.9	COG2, LPA, VCAM1, UCP2, GSTT1, CCR5
12	captopril32 42 9 9	12.8	REN, VIP, APOA1, APOB, APP, NR3C2
13	quinapril32 9 9	11.7	REN, VWF, SELE, SELP, SERPINE1, CRP
14	methionine32	9.6	RECK, VWF, SERPINA3, LPA, CD14, ITGA2
15	desmopressin32 42 9 9	12.6	REN, VWF, SELP, SERPINC1, SERPINE1, GP1BA
16	tirofiban32 9 9	11.4	VWF, SELP, SERPINC1, ITGA2, ITGA2B, ITGB3
17	phosphatidylcholine32	9.4	SELE, VIP, LPA, LPL, VCAM1, LDLR
18	sodium dodecylsulfate32	9.3	VWF, SERPINE1, LPA, LPL, CETP, ITGA2
19	fluvastatin32 34 9 9	12.2	COG2, VWF, SELP, SERPINE1, LPL, VCAM1
20	n acetylcysteine32	9.2	VWF, SELE, SELP, SERPINC1, VCAM1, MMP9
21	telmisartan32 9 9	11.1	COG2, REN, LEP, INS, CYP2C19, CRP
22	nifedipine32 9 9	10.9	REN, SELE, SERPINE1, VIP, LEP, LDLR
23	pravastatin32 34 9 18 9	12.9	COG2, SELE, SELP, SERPINE1, LPA, LDLR
24	dextran sulfate32	8.9	SELE, SELL, SELP, SERPINC1, LPL, LDLR
25	glutamate32	8.8	VIP, LEP, LDLR, BACE1, MTRR, MTHFR
26	pioglitazone32 9 9	10.8	COG2, RETN, VEGFA, LPL, VCAM1, LEP
27	glutamine32	8.8	VWF, VIP, LPL, LDLR, UCP2, MTR
28	protamine32	8.7	SELL, SELP, SERPINC1, SERPINE1, LPL, FGA
29	uric acid32 18	9.7	RETN, SERPINE1, LPA, LEP, LCN1, MTHFR
30	homocysteine32 18	9.6	COG2, RETN, VWF, SELE, SELP, SERPINC1
31	acetylcholine32 9 18 9	11.6	VWF, SERPINA3, VIP, LPL, LEP, LDLR
32	losartan32 34 9 9	11.5	REN, VWF, SELE, SELP, SERPINE1, VCAM1
33	epinephrine32 9 18 9	11.2	REN, SELE, SELL, SELP, VIP, LEP
34	calcium32 9 18 9	11.2	COG2, RECK, REN, RETN, VWF, PCLO
35	thyroxine32 18	9.2	COG2, REN, RETN, VWF, SERPINA3, VIP
36	superoxide32 18	9.2	SELL, SERPINA3, LPA, VCAM1, UCP2, LCN2
37	vitamin d32	8.0	SERPINE1, LPL, LDLR, MTHFR, CD14, ITGB3
38	estrogen32	7.6	COG2, RETN, VWF, SERPINC1, SERPINE1, SERPINA3
39	arginine32	7.6	COG2, RECK, REN, VWF, SERPINC1, SERPINA3
40	fibrinogen32	7.4	COG2, RECK, RETN, SELE, SELP, SELPLG
41	troglitazone32 42 9 9	10.2	SELE, SERPINE1, LPL, VCAM1, LEP, LDLR
42	methotrexate32 34 42 9 9	11.2	SELE, SERPINE1, SERPINA3, LEP, MTRR, MTHFR
43	alanine32	7.2	COG2, RETN, VWF, SELE, SELL, SELPLG
44	genistein32 9 18 9	10.0	SELE, SELL, SELP, SERPINE1, VEGFA, LPL
45	cholesterol32 9 18 9	9.5	COG2, RECK, REN, RETN, VWF, SELE
46	retinoic acid32 42 18	8.4	VWF, SELL, SELP, SERPINE1, SERPINA3, VCAM1
47	atorvastatin32 34 9 18 9	10.3	COG2, RETN, VWF, SELE, SELL, SELP
48	8-isoprostane32	5.9	RETN, SELE, SERPINE1, VCAM1, LEP, MMP9
49	lipid32	5.6	COG2, RECK, RETN, SELE, SELPLG, SERPINE1
50	simvastatin32 34 42 9 18 9	10.6	COG2, VWF, SELE, SELL, SELP, SERPINE1

Cellular components related to cerebrovascular disease according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	high-density lipoprotein particle	GO:034364	10.6	PON1, APOH, APOE, APOA4, APOA1, CETP
2	chylomicron	GO:042627	10.5	APOH, APOE, APOB, APOA4, LPL
3	nuclear telomere cap complex	GO:000783	10.5	POT1, ACD, TERT, TERF2IP, TERF2, TERF1
4	chromosome, telomeric region	GO:000781	10.3	POT1, ACD, TERT, TERF2IP, TERF2, TERF1
5	very-low-density lipoprotein particle	GO:034361	10.1	APOH, APOE, APOB, APOA4, APOA1, LPL
6	low-density lipoprotein particle	GO:034362	10.0	VIMP, LDLR, APOB, APOE
7	platelet alpha granule lumen	GO:031093	9.9	F13A1, ALDOA, F5, F8, APP, FGB
8	extracellular matrix	GO:031012	9.8	SOD3, PRTN3, COL4A1, PLAT, CTSG, APOH
9	secretory granule	GO:030141	9.6	PLAT, CTSG, CYBA, TRH, APOA1, INS
10	cell surface	GO:009986	9.2	APP, CCR5, TNF, CTSG, PLAT, THBD
11	integral to plasma membrane	GO:005887	9.1	ICAM1, TNF, OLR1, AGER, AGTR1, THBD
12	external side of plasma membrane	GO:009897	8.9	FGB, IL4, CCR5, ICAM1, TNF, ACE
13	plasma membrane	GO:005886	6.8	GNB3, F12, TRH, TNF, OLR1, F2
14	extracellular region	GO:005576	5.7	ADIPOQ, ADM, RETN, CD14, MMP9, INS
15	extracellular space	GO:005615	4.6	FGA, FGB, IL10, IL4, IL6, IL8

Biological processes related to cerebrovascular disease according to GeneDecks:

(show top 50)    (show all 66)

id	Name	GO ID	Score	Top Affiliating Genes
1	very-low-density lipoprotein particle remodeling	GO:034372	10.8	APOE, APOA4, CETP, LPL
2	positive regulation of cholesterol esterification	GO:010873	10.8	AGTR1, AGT, APOE, APOA4, APOA1
3	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.7	PRKCH, AGTR1, AGT, APOB, LPL
4	lipoprotein metabolic process	GO:042157	10.7	OLR1, APOE, APOB, APOA4, APOA1, CETP
5	protein localization to chromosome, telomeric region	GO:070198	10.7	ACD, TERF2IP, TERF2, TNKS2, TNKS
6	cholesterol homeostasis	GO:042632	10.7	APOE, APOB, APOA4, APOA1, CETP, LDLR
7	low-density lipoprotein particle remodeling	GO:034374	10.7	AGTR1, AGT, APOB, CETP
8	positive regulation of blood coagulation	GO:030194	10.7	F12, F2, F7, APOH, SERPINE1
9	telomere maintenance via telomerase	GO:007004	10.7	POT1, TERT, TERF2IP, TERF2, TERF1
10	fibrinolysis	GO:042730	10.6	PLAT, F12, F2, GP1BA, SERPINE1
11	cholesterol transport	GO:030301	10.6	APOB, APOA1, CETP, LDLR
12	telomere maintenance	GO:000723	10.6	POT1, ACD, TERT, TERF2IP, TERF2, TERF1
13	blood coagulation, intrinsic pathway	GO:007597	10.5	F12, F2, F8, GP1BA, APOH, VWF
14	lipid metabolic process	GO:006629	10.5	G6PD, APOE, APOB, APOA4, APOA1, CETP
15	negative regulation of fibrinolysis	GO:051918	10.5	THBD, F2, APOH, SERPINE1
16	telomere capping	GO:016233	10.5	POT1, ACD, TERF2
17	high-density lipoprotein particle remodeling	GO:034375	10.5	CETP, APOA1, APOA4, APOE
18	response to wounding	GO:009611	10.4	ADM, CX3CR1, AGER, ACHE, F2, VWF
19	negative regulation of platelet activation	GO:010544	10.4	THBD, NOS3, F2, APOE
20	positive regulation of telomere maintenance via telomerase	GO:032212	10.4	POT1, TNKS2, TNKS
21	renin-angiotensin regulation of aldosterone production	GO:002018	10.3	AGTR1, AGT, REN
22	cholesterol metabolic process	GO:008203	10.3	APOE, APOB, APOA4, APOA1, IL4, CETP
23	aging	GO:007568	10.2	ADM, SLC6A3, TSPO, AGT, NOS3, HMGCR
24	negative regulation of blood coagulation	GO:030195	10.2	THBD, APOH, APOE, SERPINE1
25	leukocyte cell-cell adhesion	GO:007159	10.2	OLR1, ICAM1, APOA4, VCAM1, SELP, SELE
26	leukocyte migration	GO:050900	10.2	THBD, OLR1, F2, ICAM1, APOB, ITGB3
27	response to lipopolysaccharide	GO:032496	10.2	ADM, THBD, LTA, CTSG, APOB, MMP9
28	regulation of blood vessel size	GO:050880	10.1	NPPB, NPPA, NOS3, CBS
29	positive regulation of cellular protein metabolic process	GO:032270	10.1	ADIPOQ, AGTR1, AGT, INS
30	platelet degranulation	GO:002576	10.0	F13A1, ALDOA, F5, F8, APP, APOA1
31	leukocyte tethering or rolling	GO:050901	9.9	TNF, LEP, VCAM1, SELPLG, SELP, SELE
32	proteolysis	GO:006508	9.8	F12, OLR1, CTSG, PLAT, ACE, PRTN3
33	regulation of blood pressure	GO:008217	9.8	NPPB, NPPA, ACTA2, ACE, NOS3, GNB3
34	negative regulation of macrophage derived foam cell differentiation	GO:010745	9.7	ADIPOQ, CRP, ITGB3, CETP
35	cell adhesion	GO:007155	9.7	GP1BA, F8, F5, ICAM1, SPP1, ACHE
36	response to organic cyclic compound	GO:014070	9.7	NPPB, NOS3, TRH, ICAM1, F7, ENO2
37	response to ethanol	GO:045471	9.5	ADIPOQ, MMP9, IL4, ICAM1, TRH, NOS3
38	G-protein coupled receptor signaling pathway	GO:007186	9.5	CX3CR1, AGTR1, AGT, GNB3, CCR5, APOE
39	negative regulation of lipid storage	GO:010888	9.5	ITGB3, IL6, TNF, CRP
40	acute-phase response	GO:006953	9.4	CRP, F2, F8, IL6, INS, SERPINA3
41	small molecule metabolic process	GO:044281	9.4	ENO2, GPI, ALDOA, GNB3, CBS, HMGCR
42	platelet activation	GO:030168	9.1	F2, F5, F8, GP1BA, APP, APOA1
43	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	ADIPOQ, AGT, CCK, IL6, INS, ITGB3
44	blood coagulation	GO:007596	9.0	APOB, APOA1, FGB, FGA, ITGB3, ITGA2B
45	response to glucocorticoid stimulus	GO:051384	9.0	ADIPOQ, ADM, PLAT, TNF, IL6, IL10
46	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.8	PRKCH, AGT, AGER, TERF2IP, TNF, ICAM1
47	cellular response to lipopolysaccharide	GO:071222	8.8	CX3CR1, TSPO, LTC4S, ICAM1, CCR5, IL8
48	response to hypoxia	GO:001666	8.5	NOS3, LTA, SOD3, NPPB, ADM, ADIPOQ
49	response to drug	GO:042493	8.3	NOS3, LTA, LTC4S, TSPO, NPPB, SLC6A3
50	inflammatory response	GO:006954	7.8	CYBA, OLR1, SPP1, CRP, C4B, AGER

Molecular functions related to cerebrovascular disease according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol transporter activity	GO:017127	10.5	APOB, APOA4, APOA1, CETP
2	eukaryotic cell surface binding	GO:043499	10.4	ADIPOQ, APOH, APOA4, FGB, FGA, SELP
3	telomeric DNA binding	GO:042162	10.4	TERT, TERF2IP, TERF2, TERF1
4	glycoprotein binding	GO:001948	10.3	F7, APOH, LDLR, SELP, VWF
5	sialic acid binding	GO:033691	10.2	SELE, SELP, ADIPOQ
6	phosphatidylcholine-sterol O-acyltransferase activator activity	GO:060228	10.1	APOE, APOA4, APOA1
7	heparin binding	GO:008201	10.1	SOD3, CTSG, APP, APOH, APOE, APOB
8	receptor binding	GO:005102	9.7	LTA, NPPA, NPPB, SLC6A3, ADM, ADIPOQ
9	enzyme binding	GO:019899	9.7	PRTN3, PRKCH, NOTCH3, CYP2C19, TNKS2, CBS
10	protease binding	GO:002020	9.4	CST3, TNF, MBP, INS, SERPINE1, SERPINC1
11	protein homodimerization activity	GO:042803	9.3	TERF2, TERT, CRP, ACHE, G6PD, PON1
12	hormone activity	GO:005179	9.1	ADIPOQ, ADM, NPPB, NPPA, AGT, CCK
13	growth factor activity	GO:008083	8.1	AGT, F2, GPI, IL6, IL4, IL10
14	cytokine activity	GO:005125	8.0	ADIPOQ, LTA, SPP1, TNF, GPI, IL6
15	protein binding	GO:005515	4.8	ADIPOQ, NOTCH3, NOS3, PLAT, CRP, NR3C2