CVA
MCID: CRB039
MIFTS: 64

Cerebrovascular Disease (CVA) malady

Cardiovascular diseases category
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Summaries for Cerebrovascular Disease

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Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 A stroke is a medical emergency. strokes happen when blood flow to your brain stops. within minutes, brain cells begin to die. there are two kinds of stroke. the more common kind, called ischemic stroke, is caused by a blood clot that blocks or plugs a blood vessel in the brain. the other kind, called hemorrhagic stroke, is caused by a blood vessel that breaks and bleeds into the brain. "mini-strokes" or transient ischemic attacks (tias), occur when the blood supply to the brain is briefly interrupted. symptoms of stroke are sudden numbness or weakness of the face, arm or leg (especially on one side of the body) sudden confusion, trouble speaking or understanding speech sudden trouble seeing in one or both eyes sudden trouble walking, dizziness, loss of balance or coordination sudden severe headache with no known cause if you have any of these symptoms, you must get to a hospital quickly to begin treatment. acute stroke therapies try to stop a stroke while it is happening by quickly dissolving the blood clot or by stopping the bleeding. post-stroke rehabilitation helps individuals overcome disabilities that result from stroke damage. drug therapy with blood thinners is the most common treatment for stroke. nih: national institute of neurological disorders and stroke

MalaCards: Cerebrovascular Disease, also known as stroke, is related to dementia and alzheimer's disease. An important gene associated with Cerebrovascular Disease is ALOX5AP (arachidonate 5-lipoxygenase-activating protein), and among its related pathways are A-beta Uptake and Degradation and Folate Metabolism. The compounds quinoline and kaolin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related mouse phenotypes are renal/urinary system and skeleton.

Disease Ontology:8 An artery disease that is characterized by dysfunction of the blood vessels supplying the brain.

NINDS:44 A stroke occurs when the blood supply to part of the brain is suddenly interrupted or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding brain cells. Brain cells die when they no longer receive oxygen and nutrients from the blood or there is sudden bleeding into or around the brain. The symptoms of a stroke include sudden numbness or weakness, especially on one side of the body; sudden confusion or trouble speaking or understanding speech; sudden trouble seeing in one or both eyes; sudden trouble with walking, dizziness, or loss of balance or coordination; or sudden severe headache with no known cause. There are two forms of stroke: - blockage of a blood vessel supplying the brain, and - bleeding into or around the brain.

Wikipedia:65 Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels... more...

Description from OMIM:47 601367

Aliases & Classifications for Cerebrovascular Disease

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8Disease Ontology, 44NINDS, 47OMIM, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
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Related Diseases for Cerebrovascular Disease

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17GeneCards, 18GeneDecks
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Diseases related to Cerebrovascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 816)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.9APOE, SERPINA3, TSPO, NOTCH3
2alzheimer's disease30.8APOE, SERPINA3, TSPO, ALOX5AP, NOTCH3
3vascular dementia30.8NOTCH3, APOE
4transient cerebral ischemia30.5APOH, MTHFR, NOTCH3
5pulmonary embolism30.4APOH, MTHFR
6stroke, ischemic30.4APOE, MTHFR, ALOX5AP, NOTCH3
7protein s deficiency30.4MTHFR, APOH
8coronary artery disease30.3SOD3, TSPO, NOTCH3
9migraine30.2APOH, MTHFR, NOTCH3
10eclampsia30.2MTHFR
11cerebral amyloid angiopathy30.2APOE
12retinal vein occlusion30.2MTHFR, APOH
13antithrombin iii deficiency30.2APOH, MTHFR
14binswanger's disease30.2NOTCH3, APOE
15protein c deficiency30.2APOH, MTHFR
16retinal artery occlusion30.1APOH
17antiphospholipid syndrome30.1MTHFR, APOH
18memory impairment30.1TSPO, APOE
19myocardial infarction30.0APOE, SELPLG, SERPINA3, SOD3, MTHFR, ALOX5AP
20hyperhomocysteinemia30.0APOE, APOH, SOD3, MTHFR
21down syndrome30.0MTHFR, SERPINA3, APOE
22brain disease29.9NOTCH3, TSPO, SERPINA3
23prion disease29.9APOE, SERPINA3, TSPO
24multiple sclerosis29.9APOE, SELPLG, TSPO, CX3CR1, NOTCH3
25hypercholesterolemia29.9FABP2, SELPLG, APOE
26psoriasis29.8CX3CR1, SERPINA3
27parkinson's disease29.8APOE, SERPINA3, TSPO
28thrombophilia29.8F12, APOH, MTHFR
29type 2 diabetes mellitus29.8APOE, FABP2, MTHFR
30thromboembolism29.8MTHFR, SERPINA3, APOH, F12
31asthma29.7ALOX5AP, CX3CR1, TSPO, SERPINA3, SELPLG
32venous thrombosis29.7F12, APOH, SELPLG, MTHFR
33amyotrophic lateral sclerosis29.7TSPO
34thrombophlebitis29.7APOH
35hemorrhage, intracerebral29.7APOE, SERPINA3
36atherosclerosis29.7APOE, APOH, SELPLG, SOD3, FABP2, CX3CR1
37vascular disease29.6APOE, APOH, SOD3, MTHFR, NOTCH3
38creutzfeldt-jakob disease29.6APOE, SERPINA3, TSPO
39factor v leiden thrombophilia29.6SERPINA3, SELPLG, F12
40multiple system atrophy29.6SERPINA3, TSPO
41osteoarthritis29.6ALOX5AP, CX3CR1, TSPO, SERPINA3
42rheumatoid arthritis29.5APOH, SERPINA3, SOD3, TSPO, CX3CR1, MTHFR
43primary hyperoxaluria29.5APOE, SOD3, MTHFR
44lactic acidosis10.7
45cerebral artery occlusion10.5
46mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.5
47cerebritis10.5
48atrial septal aneurysm10.5
49peripheral vascular disease10.5
50myopathy10.5

Graphical network of the top 20 diseases related to Cerebrovascular Disease:



Diseases related to cerebrovascular disease

Symptoms for Cerebrovascular Disease

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47OMIM
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Clinical features from OMIM:

601367

Drugs & Therapeutics for Cerebrovascular Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cerebrovascular Disease

Search NIH Clinical Center for Cerebrovascular Disease

Genetic Tests for Cerebrovascular Disease

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Anatomical Context for Cerebrovascular Disease

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33MalaCards
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MalaCards organs/tissues related to Cerebrovascular Disease:

33
Brain, Eye, Heart, Endothelial, Testes, Pituitary, Thyroid, Kidney, T cells, Smooth muscle, Temporal lobe, Thalamus, Skin

Animal Models for Cerebrovascular Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cerebrovascular Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7APOE, SELPLG, FABP2, CX3CR1, NOTCH3
2MP:00053908.2APOE, SOD3, MTHFR, ALOX5AP, NOTCH3
3MP:00107718.2APOE, SELPLG, CX3CR1, MTHFR, NOTCH3
4MP:00053877.9NOTCH3, ALOX5AP, CX3CR1, SOD3, SELPLG, APOE
5MP:00107686.9APOE, APOH, SELPLG, SOD3, CX3CR1, MTHFR
6MP:00053766.1NOTCH3, F12, APOE, APOH, SELPLG, SOD3

Publications for Cerebrovascular Disease

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Sources:
52PubMed
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Articles related to Cerebrovascular Disease:

(show top 50)    (show all 646)
idTitleAuthorsYear
1
Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. (24375839)
2014
2
Association of fasting glucose with subclinical cerebrovascular disease in older adults without Type 2 diabetes. (24344757)
2013
3
Subclinical left ventricular dysfunction and silent cerebrovascular disease: the Cardiovascular Abnormalities and Brain Lesions (CABL) study. (23902759)
2013
4
Long-term survival of ischemic cerebrovascular disease in the acute inflammatory stroke study, a hospital-based cohort described by TOAST and ASCO. (23466736)
2013
5
LA volumes and reservoir function are associated with subclinical cerebrovascular disease: the CABL (Cardiovascular Abnormalities and Brain Lesions) study. (23473112)
2013
6
Assessment of Stroke and Concomitant Cerebrovascular Disease with Heart Disease Requires Invasive Treatment: Analysis of 249 Consecutive Patients with Heart Disease. (24065603)
2013
7
Heterozygous TREX1 mutations in early-onset cerebrovascular disease. (23881107)
2013
8
Letter by castilla-guerra and fernandez-moreno regarding article, "average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people". (22689938)
2012
9
Evolving role of biomarkers in acute cerebrovascular disease. (22451199)
2012
10
Novel MRI approaches for assessing cerebral hemodynamics in ischemic cerebrovascular disease. (22343644)
2012
11
The effectiveness of smoking cessation interventions in smokers with cerebrovascular disease: a systematic review. (23263022)
2012
12
Concurrent Koro and Cotard syndromes in a Spanish male patient with a psychotic depression and cerebrovascular disease. (22310658)
2012
13
A multidisciplinary stroke clinic for outpatient care of veterans with cerebrovascular disease. (21594062)
2011
14
Oxidative stress and endothelial dysfunction in cerebrovascular disease. (21196259)
2011
15
A genome-wide study of moyamoya-type cerebrovascular disease in the korean population. (22323933)
2011
16
The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study. (20677172)
2011
17
Prevalence of radiological and clinical cerebrovascular disease in idiopathic Parkinson's disease. (21689880)
2011
18
Diabetes, hyperglycemia and the management of cerebrovascular disease. (21124220)
2011
19
Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. (21387371)
2011
20
Hepatitis C virus infection and increased risk of cerebrovascular disease. (20966408)
2010
21
Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort. (20457955)
2010
22
Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study. (20955612)
2010
23
The structural and functional consequences of diurnal variations in blood pressure in treated patients with hypertensive cerebrovascular disease. (19337131)
2009
24
Diabetes mellitus and cerebrovascular disease: which are the actual data? (18358748)
2009
25
CD14 C260T promoter polymorphism and the risk of cerebrovascular diseases: a meta-analysis. (19433913)
2009
26
Prophylactic, endovascularly based, long-term normothermia in ICU patients with severe cerebrovascular disease: bicenter prospective, randomized trial. (19762706)
2009
27
The association of obesity and cerebrovascular disease in young adults--a pilot study. (20055251)
2009
28
Retinal vascular signs and cerebrovascular disease. (19426407)
2009
29
Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry. (19815240)
2009
30
A role for monomeric C-reactive protein in regulation of angiogenesis, endothelial cell inflammation and thrombus formation in cardiovascular/cerebrovascular disease? (19760596)
2009
31
Aspirin resistance determined with PFA-100 does not predict new thrombotic events in patients with stable ischemic cerebrovascular disease. (19084329)
2009
32
Cerebrovascular disease. (19272513)
2009
33
Prevalence of hypopituitarism in patients with cerebrovascular diseases. (19020380)
2008
34
Update on the genetics of stroke and cerebrovascular disease 2007. (18187682)
2008
35
Galantamine for the treatment of BPSD in Thai patients with possible Alzheimer's disease with or without cerebrovascular disease. (18845693)
2008
36
Can the detection of misery perfusion in chronic cerebrovascular disease be based on reductions in baseline CBF and vasoreactivity? (16896662)
2007
37
Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. (17568241)
2007
38
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
39
Commentary. Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. (16110388)
2005
40
Association of the apolipoprotein A-IV: 360 Gln/His polymorphism with cerebrovascular disease, obesity, and depression in a Brazilian elderly population. (15806598)
2005
41
Factor V Leiden mutation in cerebrovascular disease. (16015421)
2005
42
Benefits of statins in cerebrovascular disease. (15083596)
2004
43
123I-FP-CIT SPECT imaging of dopamine transporters in patients with cerebrovascular disease and clinical diagnosis of vascular parkinsonism. (15471834)
2004
44
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. (11965273)
2002
45
Polymorphisms of P-selectin glycoprotein ligand-1 are associated with neutrophil-platelet adhesion and with ischaemic cerebrovascular disease. (11843835)
2001
46
Statins and cerebrovascular disease: plaque attack to prevent brain attack. (10613632)
1999
47
Assessment of benzodiazepine receptors using iodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease. A comparison with PET study. (9303025)
1997
48
Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma. (8523390)
1995
49
Serum aldolase isozyme levels in patients with cerebrovascular diseases. (2240017)
1990
50
Biometeorologic studies on cerebrovascular diseases. I. Effects of meteorologic factors on the death from cerebrovascular accident. (5395972)
1969

Variations for Cerebrovascular Disease

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Expression for genes affiliated with Cerebrovascular Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebrovascular Disease

Search GEO for disease gene expression data for Cerebrovascular Disease.

Pathways for genes affiliated with Cerebrovascular Disease

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Sources:
50PathCards, 54R&D Systems, 38NCBI BioSystems Database
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Pathways related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CX3CR1, APOE
2
Show member pathways
Vitamin B12 Metabolism38
8.8MTHFR, SOD3, APOE
3
Show member pathways
thioredoxin pathway38
8.6ALOX5AP, MTHFR, SOD3, SERPINA3

Compounds for genes affiliated with Cerebrovascular Disease

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Sources:
45Novoseek, 29IUPHAR, 3BitterDB, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1quinoline4510.1ALOX5AP, TSPO
2kaolin459.9APOH, F12
3sele459.9MTHFR, APOE
422r-hydroxycholesterol45 2910.9TSPO, APOE
5thiamine45 3 24 1112.9TSPO, APOE
6linoleic acid29 45 2411.8FABP2, CX3CR1, ALOX5AP
7isoflurane51 45 1111.8TSPO, SELPLG
8vitamin a45 24 1111.7FABP2, SERPINA3, APOE
9spec-t459.7APOE, TSPO
10fenofibrate45 51 1111.7FABP2, APOE
11carbohydrates459.6APOE, SELPLG, FABP2
12indomethacin45 29 61 1112.5ALOX5AP, TSPO, APOE
13sialic acid459.5APOH, SELPLG, SERPINA3
14warfarin45 51 24 1112.4MTHFR, APOH, APOE
15disulfiram45 51 61 1112.3MTHFR, TSPO
16methotrexate51 45 1111.3APOH, SERPINA3, MTHFR
17urea45 24 1111.3FABP2, SOD3, SERPINA3
18histamine45 29 2411.2SELPLG, TSPO, ALOX5AP
19phospholipid459.1FABP2, APOH, APOE
20phenytoin45 51 29 1112.1MTHFR, TSPO
21dopamine45 29 24 1112.1APOE, SERPINA3, TSPO, MTHFR
22vitamin b12459.1MTHFR, SERPINA3, APOH, APOE
23betacarotene459.1APOE, APOH, SERPINA3, MTHFR
24methionine459.0SERPINA3, SOD3, MTHFR
25ascorbic acid45 2410.0APOE, SOD3, MTHFR
26uric acid45 249.9MTHFR, SOD3, APOH
27acetylcholine45 51 29 24 1112.9APOE, SERPINA3, SOD3, TSPO
28iron45 249.8ALOX5AP, SOD3, SERPINA3, APOH
29aspirin45 51 29 2411.8F12, APOE, APOH, MTHFR, ALOX5AP
30nadph45 249.8SERPINA3, SOD3, FABP2, MTHFR
31vitamin d458.8APOE, SOD3, FABP2, MTHFR
32fibrinogen458.7F12, APOH, SELPLG, SERPINA3, MTHFR
33glutamate458.6MTHFR, TSPO, APOH, APOE
34alpha tocopherol458.6APOE, APOH, SOD3, MTHFR
35homocysteine45 249.6APOE, APOH, SOD3, MTHFR
36vegf458.6APOE, APOH, SOD3, CX3CR1
37calcium45 51 24 1111.5APOH, SELPLG, SERPINA3, CX3CR1, ALOX5AP, NOTCH3
38zinc45 249.4F12, APOH, SERPINA3, SOD3, FABP2
39oxygen45 249.3APOH, SELPLG, SERPINA3, SOD3, CX3CR1
40folate458.3APOE, APOH, SERPINA3, SOD3, MTHFR
41estrogen458.2F12, APOE, APOH, SERPINA3, TSPO, MTHFR
42valine458.2MTHFR, TSPO, FABP2, SERPINA3, APOH, APOE
43creatinine458.2APOE, APOH, SERPINA3, FABP2, TSPO, MTHFR
44serine458.1F12, APOE, SELPLG, SERPINA3, SOD3, MTHFR
45alanine458.0APOE, SELPLG, SERPINA3, SOD3, FABP2, MTHFR
46arginine458.0APOE, APOH, SERPINA3, SOD3, TSPO, NOTCH3
47cysteine457.7APOE, SELPLG, SERPINA3, SOD3, FABP2, MTHFR
48lipid457.7APOE, APOH, SELPLG, SERPINA3, SOD3, FABP2
49heparin45 29 24 1110.5F12, APOE, APOH, SELPLG, SERPINA3, SOD3
50cholesterol45 29 24 1110.4APOE, APOH, SELPLG, SERPINA3, SOD3, FABP2

GO Terms for genes affiliated with Cerebrovascular Disease

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16Gene Ontology
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Cellular components related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.5APOH, APOE
2very-low-density lipoprotein particleGO:0343619.4APOH, APOE
3high-density lipoprotein particleGO:0343649.2APOE, APOH
4extracellular regionGO:0055768.4NOTCH3, SOD3, SERPINA3, APOE, F12

Biological processes related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:0140129.7TSPO, APOE
2positive regulation of blood coagulationGO:0301949.6APOH, F12
3negative regulation of blood coagulationGO:0301959.5APOH, APOE
4blood coagulation, intrinsic pathwayGO:0075979.5F12, APOH
5negative regulation of angiogenesisGO:0165259.5CX3CR1, APOH
6negative regulation of endothelial cell proliferationGO:0019379.4APOH, APOE
7triglyceride metabolic processGO:0066419.2APOH, APOE

Molecular functions related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082018.7SOD3, APOH, APOE
2protein bindingGO:0055156.4NOTCH3, F12, APOE, APOH, SELPLG, SERPINA3

Products for genes affiliated with Cerebrovascular Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebrovascular Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet