MCID: CRB039
MIFTS: 53

Cerebrovascular Disease malady

Cardiovascular category

Summaries for Cerebrovascular Disease

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels... more...

MalaCards: Cerebrovascular Disease, also known as cerebrovascular disorders, is related to vascular disease and brain disease. An important gene associated with Cerebrovascular Disease is NOTCH3 (notch 3), and among its related pathways are Selenium Pathway and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds cysteine and cholesterol have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Cerebrovascular Disease

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

cerebrovascular disease 8 45
cerebrovascular disorders 61
cerebrovascular disorder 8


External Ids:

Disease Ontology8 DOID:6713
NCIt40 C2938
MeSH35 D002561

Related Diseases for Cerebrovascular Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cerebrovascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease31.0SOD3, APOH, CBS, SELPLG, TSPO
2brain disease30.8TSPO, BACE1, SERPINA3, NOTCH3
3vascular dementia30.7SERPINA3, NOTCH3, MTHFR, ACHE, APOE, PON1
4alzheimer's disease30.6CETP, CBS, APOE, MTR, BACE1, PON1
5stroke, ischemic30.5ADM, NOTCH3, MTHFR, APOE
6coronary artery disease,30.5SOD3, APOE, MTHFR, MTR, PON1, CETP
7coronary heart disease30.4CBS, PON1, MTR, MTHFR, FABP2, CETP
8cadasil30.2NOTCH3
9systemic lupus erythematosus30.2APOH, PON1, RECK, CX3CR1
10atherosclerosis30.1SOD3, APOE, APOH, FABP2, MTHFR, MTR
11memory impairment30.1ACHE, TSPO, BACE1, APOE, TRH
12acute myocardial infarction30.1SOD3, PON1, CBS, ADM
13parkinson's disease30.1APOE, TSPO, ACHE, PON1, SERPINA3, MTR
14insulin resistance30.1CETP, SOD3, FABP2, PON1
15arthritis30.1SERPINA3, SOD3
16homocysteinemia30.1MTHFR, CBS, MTR
17venous thrombosis29.9F12, MTR, MTHFR, APOH, CBS, SELPLG
18hypercholesterolemia29.9PON1, APOE, CBS, CETP, FABP2, SELPLG
19thromboembolism29.9MTR, F12, MTHFR, SERPINA3, CBS, APOH
20asthma29.9ADM, TSPO, RECK, SELPLG, CX3CR1, PON1
21thrombophilia29.9CBS, F12, MTHFR, APOH
22abdominal aortic aneurysm29.9APOE
23binswanger's disease29.9ACHE, NOTCH3, APOE
24antiphospholipid syndrome29.9MTHFR, APOH, PON1
25infertility29.9PON1
26protein c deficiency29.9APOH, MTHFR
27carotid stenosis29.9PON1
28cerebral amyloid angiopathy29.9PON1, APOE
29peripheral vascular disease29.9CBS, MTHFR
30deficiency anemia29.9MTR, ADM, TRH
31lip disease10.5
32sickle cell disease10.4
33sickle cell anemia10.3
34cerebrovascular disease, occlusive10.3
35moyamoya disease10.3
36fabry disease10.3
37aneurysm disease10.2
38cardiovascular disease risk factor10.2
39basal ganglia cerebrovascular disease10.2
40restless legs syndrome10.2
41aspiration pneumonia10.2
42sleep apnea10.2
43mitochondrial disorders10.1
44mitochondrial genetic disorders10.1
45stomach cancer10.1
46stomach disease10.1
47thalassemia10.1
48headache10.1
49stroke, hemorrhagic10.1
50dementia10.0APOE, MTR, BACE1, TRH, PON1, CBS

Graphical network of the top 20 diseases related to Cerebrovascular Disease:



Diseases related to cerebrovascular disease

Clinical Features for Cerebrovascular Disease

Drugs & Therapeutics for Cerebrovascular Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cerebrovascular Disease

Drug clinical trials:

Search ClinicalTrials for Cerebrovascular Disease

Search NIH Clinical Center for Cerebrovascular Disease

Search CenterWatch for Cerebrovascular Disease

Genetic Tests for Cerebrovascular Disease

Anatomical Context for Cerebrovascular Disease

Animal Models for Cerebrovascular Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cerebrovascular Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9FABP2, MTHFR, SOD3, ADM, SELPLG, APOE
2MP:001076810.8ADM, SOD3, APOE, APOH, MTHFR, MTR
3MP:001077110.7BACE1, SELPLG, CX3CR1, CBS, RECK
4MP:000536710.6FABP2, CBS, CX3CR1, SELPLG, ADM
5MP:000363110.6APOE, MTHFR, F12, BACE1, TRH, CX3CR1
6MP:000536910.6ADM, CX3CR1, CBS, BACE1, APOE, ACHE
7MP:000537810.5MTHFR, TRH, APOE, ACHE, FABP2, CBS
8MP:000539510.2ADM, RECK, BACE1, APOE

Publications for Cerebrovascular Disease

Sources:
51PubMed
See all sources

Articles related to Cerebrovascular Disease:

(show top 50)    (show all 765)
idTitleAuthorsYear
1
Implications of aspirin biochemistry in the pathobiology of ischemic cerebrovascular disease. (24139840)
2014
2
Trapping of Endovascular Microguidewire: A Rare and Serious Complication During Therapeutic Microcatheterization for Cerebrovascular Disease. (24382599)
2014
3
Association of fasting glucose with subclinical cerebrovascular disease in older adults without Type 2 diabetes. (24344757)
2013
4
Hemodynamics and changes after STA-MCA anastomosis in moyamoya disease and atherosclerotic cerebrovascular disease measured by micro-Doppler ultrasonography. (23192651)
2013
5
Restless legs syndrome and cerebrovascular disease - authors' reply. (23867192)
2013
6
The natural history of cerebrovascular disease: a closer look at paraclinoid aneurysms and epileptogenic AVMs. (23868945)
2013
7
Anxiety contributes to the development of cerebrovascular disease in Taiwanese patients with psoriasis: a population-based study. (23568667)
2013
8
Cerebrovascular complications in children with sickle cell disease. (23622417)
2013
9
Prevalence and subtypes of radiological cerebrovascular disease in late-onset isolated seizures and epilepsy. (22840415)
2013
10
Shared associations of nonatherosclerotic, large-vessel, cerebrovascular arteriopathies: considering intracranial aneurysms, cervical artery dissection, moyamoya disease and fibromuscular dysplasia. (23302803)
2013
11
Epworth Sleepiness Scale may be an indicator for blood pressure profile and prevalence of coronary artery disease and cerebrovascular disease in patients with obstructive sleep apnea. (21243439)
2012
12
Small vessel cerebrovascular disease: the past, present, and future. (22315706)
2012
13
Letter by Lagro et al regarding article, "average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people". (22689937)
2012
14
Reactive oxygen species and ischemic cerebrovascular disease. (22122807)
2012
15
Rabeprazole reduces the recurrence risk of peptic ulcers associated with low-dose aspirin in patients with cardiovascular or cerebrovascular disease: a prospective randomized active-controlled trial. (22526273)
2012
16
Assessing the role of cerebrovascular disease in the incidence of geriatric depression. (23118037)
2012
17
The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study. (20677172)
2011
18
Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. (21387371)
2011
19
Cerebrovascular disease pathology and parkinsonian signs in old age. (21885844)
2011
20
High reticulocyte count is an independent risk factor for cerebrovascular disease in children with sickle cell anemia. (20949593)
2011
21
Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS). (21316677)
2011
22
Risk factor profiles of South Asians with cerebrovascular disease. (21745346)
2011
23
Sugar and stroke: cerebrovascular disease and blood glucose control. (20491782)
2011
24
Cerebrovascular disease incidence in central Spain (NEDICES): a population-based prospective study. (20817180)
2010
25
Clinical application of blood biomarkers in cerebrovascular disease. (20136376)
2010
26
Prophylactic, endovascularly based, long-term normothermia in ICU patients with severe cerebrovascular disease: bicenter prospective, randomized trial. (19762706)
2009
27
Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome. (19949034)
2009
28
Intracranial internal carotid artery calcifications: association with vascular risk factors and ischemic cerebrovascular disease. (18842764)
2009
29
Severity of coronary artery disease but not degree of coronary stenosis is correlated to cerebrovascular reactivity. (19609081)
2009
30
Doppler embolic signals in cerebrovascular disease and prediction of stroke risk: a systematic review and meta-analysis. (19850894)
2009
31
Geographic hierarchies of diagnostic practice style in cerebrovascular disease. (19346048)
2009
32
Acute myocardial infarction, ischemic cerebrovascular disease and variceal bleeding due to portal vein thrombosis in a patient with hereditary thrombophilia. (18388507)
2008
33
Cardiovascular risk factor management is poorer in diabetic patients with undiagnosed peripheral arterial disease than in those with known coronary heart disease or cerebrovascular disease. Results of a nationwide study in tertiary diabetes centres. (18341592)
2008
34
Risk factors for cerebrovascular disease and cognitive function in the elderly. (17906814)
2007
35
Cerebrovascular disease associated with Aarskog-Scott syndrome. (17294235)
2007
36
No effect of low-dose statins treatment on cerebral blood flow in humans with atherosclerotic cerebrovascular disease. (17356563)
2007
37
Effect of scatter and attenuation correction in ROI analysis of brain perfusion scintigraphy: phantom experiment and clinical study in patients with unilateral cerebrovascular disease. (17549321)
2007
38
Monitoring cognitive characteristics in a population with hereditary cerebrovascular disease (CADASIL) in Colombia]. (18075987)
2007
39
Cerebrovascular disease, APOE epsilon4 allele and cognitive decline in a cognitively normal population. (16945218)
2006
40
Training in cerebrovascular disease: do we need to change the way we train residents? (17053614)
2006
41
Selection of thrombogenetic antiphospholipid antibodies in cerebrovascular disease patients. (12736740)
2003
42
Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study. (12578879)
2003
43
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. (11965273)
2002
44
Correlation analysis between plasma homocysteine level and polymorphism of homocysteine metabolism related enzymes in ischemic cerebrovascular or cardiovascular diseases]. (12015064)
2002
45
Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise. (10818509)
2000
46
Association between severe cerebral amyloid angiopathy and cerebrovascular lesions in Alzheimer disease is not a spurious one attributable to apolipoprotein E4. (10867785)
2000
47
Frequencies of certain complement protein alleles and serum levels of anti-heat-shock protein antibodies in cerebrovascular diseases. (11062289)
2000
48
Angiotensin-converting enzyme insertion/deletion polymorphism and cerebrovascular disease. (8610309)
1996
49
Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease. (6506111)
1984
50
Rehabilitation of patients with cardiac disease and associated cerebrovascular accident. (424822)
1979

Genetic Variations for Cerebrovascular Disease

Expression for genes affiliated with Cerebrovascular Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cerebrovascular Disease

Search GEO for disease gene expression data for Cerebrovascular Disease.

Pathways for genes affiliated with Cerebrovascular Disease

Sources:
38NCBI BioSystems Database, 50PharmGKB, 54Reactome
See all sources

Compounds for genes affiliated with Cerebrovascular Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1cysteine4511.2CBS, FABP2, APOE, SOD3, RECK, NOTCH3
2cholesterol45 29 11 2414.1MTHFR, FABP2, APOH, APOE, SOD3, BACE1
3lipid4511.1ADM, FABP2, SELPLG, SERPINA3, CETP, PON1
4arginine4511.1ADM, CETP, SERPINA3, NOTCH3, SOD3, CBS
5heparin45 29 11 2414.1BACE1, PON1, SERPINA3, CETP, MTHFR, APOH
6homocysteine45 2412.1APOE, APOH, SOD3, MTHFR, PON1, MTR
7folate4511.1SERPINA3, RECK, CBS, MTR, PON1, MTHFR
8alanine4511.0ADM, SOD3, APOE, SELPLG, CETP, PON1
9creatinine4511.0FABP2, MTR, MTHFR, ADM, TSPO, SERPINA3
10acetylcholine45 50 29 11 2415.0SOD3, APOE, BACE1, PON1, ACHE, SERPINA3
11serine4511.0SERPINA3, SELPLG, ACHE, CBS, BACE1, F12
12vitamin b124511.0MTHFR, MTR, PON1, APOE, APOH, CBS
13fibrinogen4511.0PON1, CBS, RECK, SELPLG, SERPINA3, APOH
14valine4511.0CETP, TSPO, SERPINA3, MTR, FABP2, APOE
15betacarotene4511.0SERPINA3, PON1, MTHFR, APOH, APOE, CETP
16estrogen4511.0F12, BACE1, TRH, CETP, APOH
17methionine4511.0SERPINA3, RECK, CBS, MTR, MTHFR, PON1
18phospholipid4511.0PON1, CETP, FABP2, APOE, APOH, BACE1
19zinc45 2412.0APOH, SOD3, FABP2, MTR, F12, BACE1
20oxygen45 2412.0CX3CR1, SERPINA3, SELPLG, BACE1, SOD3, ADM
21aspirin45 50 29 2413.9APOH, APOE, CETP, MTHFR, PON1, F12
22superoxide45 2411.9SOD3, APOH, SERPINA3, BACE1
23copper45 2411.9CBS, BACE1, APOH, MTR, SOD3
24sele4510.9PON1, CETP, MTHFR, APOE
25ascorbic acid45 2411.9CETP, MTHFR, PON1, BACE1, APOE, SOD3
26glutamate4510.9ACHE, APOH, BACE1, TRH, TSPO
27cystathionine4510.9MTR, PON1, CBS, MTHFR
28alpha tocopherol4510.9APOH
29carbohydrates4510.9APOE, CETP, SELPLG, RECK, FABP2
30sialic acid4510.9SELPLG, APOH, SERPINA3, RECK, BACE1
315,10-methenyltetrahydrofolate4510.9CBS, MTHFR, MTR
32b vitamins4510.9CBS, MTHFR, MTR
33thyroxine45 2411.9APOE, PON1, SERPINA3, TRH, CETP
34testosterone45 60 11 2413.9TSPO, CETP, APOE, ADM, MTHFR, TRH
35methylcobalamin45 2411.9MTHFR, MTR, CBS
36h2o24510.8TSPO, PON1, BACE1
375-methyltetrahydrofolate45 1111.8MTHFR, MTR, CBS
38glucose4510.8TRH, APOH, ADM, SERPINA3, RECK
39phosphatidylcholine4510.8CETP, PON1, ADM, APOH, APOE
40malondialdehyde4510.8SOD3, APOH, PON1, ADM
41nadph45 2411.8ADM, FABP2, SOD3, MTR
42vitamin a45 11 2412.7SERPINA3, PON1, FABP2, APOE, CETP
43cyclosporin a45 29 6012.7CETP, TSPO, ADM, RECK
44methotrexate45 50 1112.7SERPINA3, MTR, MTHFR, APOH, CBS
45betaine45 2411.7MTHFR, MTR, CBS
46hydrogen45 2411.6MTR, CBS, FABP2, TRH, BACE1
47methylmalonic acid45 2411.5CBS, MTR, MTHFR
48cobalamin45 2411.5MTHFR, MTR, CBS
49dopamine45 29 11 2413.4TRH, TSPO, SERPINA3
50uric acid45 2411.2SOD3, APOH

GO Terms for genes affiliated with Cerebrovascular Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:03436410.5CETP, PON1, APOH, APOE
2extracellular spaceGO:00561510.5SOD3, APOE, APOH, F12, PON1, ACHE
3chylomicronGO:04262710.5APOH, APOE
4extracellular regionGO:00557610.3APOE, F12, TRH, PON1, NOTCH3, ACHE

Biological processes related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:00664110.8CETP, APOH, APOE
2peripheral nervous system axon regenerationGO:01401210.8TSPO, APOE
3response to woundingGO:00961110.8ADM, ACHE, CX3CR1
4homocysteine metabolic processGO:05066710.7MTHFR, CBS
5very-low-density lipoprotein particle remodelingGO:03437210.7CETP, APOE
6cholesterol metabolic processGO:00820310.7CETP, PON1, APOE
7phosphatidylcholine metabolic processGO:04647010.7PON1, CETP
8positive regulation of cholesterol effluxGO:01087510.7PON1, APOE
9positive regulation of blood coagulationGO:03019410.6F12, APOH
10low-density lipoprotein particle remodelingGO:03437410.6CETP, APOE
11agingGO:00756810.5APOE, TSPO, ADM
12synaptic transmission, cholinergicGO:00727110.5ACHE, APOE
13negative regulation of blood coagulationGO:03019510.4APOH, APOE
14high-density lipoprotein particle remodelingGO:03437510.2CETP, APOE

Molecular functions related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid bindingGO:00828910.5CETP, APOH, APOE
2modified amino acid bindingGO:07234110.5CBS, MTHFR
3cholesterol transporter activityGO:01712710.4CETP, APOE
4lipid transporter activityGO:00531910.2CETP, APOE

Products for genes affiliated with Cerebrovascular Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cerebrovascular Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet