MCID: CRB039
MIFTS: 61

Cerebrovascular Disease malady

Cardiovascular diseases category

Summaries for Cerebrovascular Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels... more...

MalaCards: Cerebrovascular Disease, also known as cerebrovascular disorders, is related to vascular disease and dementia. An important gene associated with Cerebrovascular Disease is NOTCH3 (notch 3), and among its related pathways are Selenium Pathway and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds cysteine and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Cerebrovascular Disease

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Cerebrovascular Disease

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17GeneCards, 18GeneDecks
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Diseases related to Cerebrovascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease31.0MTR, MTHFR, APOH, APOE, SOD3, PON1
2dementia30.9CETP, TSPO, SERPINA3, ACHE, NOTCH3, CBS
3alzheimer's disease30.9APOE, MTR, BACE1, PON1, CBS, RECK
4brain disease30.8TSPO, SERPINA3, NOTCH3, BACE1
5stroke, ischemic30.7APOE, MTHFR, NOTCH3, ADM
6hypertension30.7APOE, MTHFR, ADM
7vascular dementia30.6APOE, MTHFR, PON1, NOTCH3, ACHE, SERPINA3
8diabetes mellitus30.6APOE, FABP2, MTHFR, PON1, RECK, CETP
9coronary artery disease30.5CETP, SELPLG, CX3CR1, RECK, CBS, PON1
10cadasil30.4NOTCH3
11pneumonia30.4SOD3, ADM
12myocardial infarction30.3ADM, CETP, SERPINA3, SELPLG, RECK, CBS
13obesity30.3APOE, FABP2, TRH, PON1, CBS, CETP
14ischemic heart disease30.3SOD3, PON1, NOTCH3, TSPO, CETP, ADM
15migraine30.3APOH, MTHFR, NOTCH3
16ischemia30.2CBS, PON1, FABP2, SELPLG, ADM
17lupus erythematosus30.2APOH
18systemic lupus erythematosus30.2APOH, PON1, RECK, CX3CR1
19atherosclerosis30.1CETP, SELPLG, CX3CR1, RECK, CBS, PON1
20acute myocardial infarction30.1SOD3, PON1, CBS, ADM
21arthritis30.1SERPINA3, SOD3
22binswanger's disease30.1APOE, NOTCH3, ACHE
23thyroiditis30.1TRH
24cerebral amyloid angiopathy30.1PON1, APOE
25type 2 diabetes mellitus29.8APOE, FABP2, MTHFR, PON1, RECK, ACHE
26rheumatoid arthritis29.8SOD3, APOH, MTHFR, PON1, RECK, CX3CR1
27asthma29.8PON1, RECK, CX3CR1, SELPLG, SERPINA3, TSPO
28thrombophilia29.8APOH, MTHFR, F12, CBS
29parkinson's disease29.8APOE, MTR, PON1, ACHE, SERPINA3, TSPO
30prion disease29.8APOE, BACE1, ACHE, SERPINA3, TSPO
31abdominal aortic aneurysm29.8APOE
32psoriasis29.8CX3CR1, SERPINA3
33antiphospholipid syndrome29.8PON1, MTHFR, APOH
34infertility29.8PON1
35glaucoma29.8ACHE, PON1
36carotid stenosis29.8PON1
37peripheral vascular disease29.8MTHFR, CBS
38deficiency anemia29.8ADM, TRH, MTR
39cerebritis10.5
40moyamoya disease10.4
41carotid artery disease10.3
42sickle cell disease10.3
43sickle cell anemia10.3
44hemorrhagic disease10.3
45fabry disease10.3
46aneurysm disease10.2
47neurologic diseases10.2
48basal ganglia cerebrovascular disease10.1
49cerebral arteritis10.1
50cerebral atherosclerosis10.1

Graphical network of the top 20 diseases related to Cerebrovascular Disease:



Diseases related to cerebrovascular disease

Clinical Features for Cerebrovascular Disease

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Drugs & Therapeutics for Cerebrovascular Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebrovascular Disease

Drug clinical trials:

Search ClinicalTrials for Cerebrovascular Disease

Search NIH Clinical Center for Cerebrovascular Disease

Search CenterWatch for Cerebrovascular Disease

Genetic Tests for Cerebrovascular Disease

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Anatomical Context for Cerebrovascular Disease

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32MalaCards
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MalaCards organs/tissues related to Cerebrovascular Disease:

32
Brain, Heart, Endothelial, Testes, Smooth muscle, Pituitary, Thyroid, Kidney, Skin, T cells, Temporal lobe, Thalamus

Animal Models for Cerebrovascular Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cerebrovascular Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9ADM, SOD3, APOE, APOH, FABP2, MTHFR
2MP:001076810.8SOD3, APOE, APOH, MTHFR, MTR, BACE1
3MP:001077110.7BACE1, CBS, RECK, CX3CR1, SELPLG
4MP:000536710.6FABP2, CBS, CX3CR1, SELPLG, ADM
5MP:000363110.6MTHFR, F12, BACE1, TRH, RECK, CX3CR1
6MP:000536910.6APOE, BACE1, CBS, CX3CR1, NOTCH3, ACHE
7MP:000537810.5APOE, FABP2, MTHFR, BACE1, TRH, CBS
8MP:000539510.2APOE, BACE1, RECK, ADM

Publications for Cerebrovascular Disease

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50PubMed
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Articles related to Cerebrovascular Disease:

(show top 50)    (show all 763)
idTitleAuthorsYear
1
Insomnia, daytime sleepiness and cardio-cerebrovascular diseases in the elderly: a 6-year prospective study. (23457496)
2013
2
A different reason for cerebrovascular disease. (23399346)
2013
3
Regional cerebral blood flow and cerebrovascular reactivity in Alzheimer's disease and vascular dementia assessed by arterial spinlabeling magnetic resonance imaging. (23151075)
2013
4
Genetic stabilization of transthyretin, cerebrovascular disease, and life expectancy. (23580146)
2013
5
Ischemic cerebrovascular disease and calcified intracranial vertebrobasilar artery: A case-control study by using cranial CT. (23539940)
2013
6
Diabetes mellitus and cerebrovascular disease as independent determinants for increased hospital costs and length of stay in open appendectomy in comparison with laparoscopic appendectomy: a nationwide cohort study. (22524772)
2012
7
Letter by castilla-guerra and fernandez-moreno regarding article, "average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people". (22689938)
2012
8
Lack of nocturnal blood pressure fall in elderly bedridden hypertensive patients with cerebrovascular disease. (22217102)
2012
9
Alpha-thalassemia protects against cerebrovascular disease in children with sickle cell anemia. (22899043)
2012
10
Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer's disease. (22451309)
2012
11
Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors. (23207766)
2012
12
Childhood cerebrovascular disease: current understanding and future directions. (21836123)
2011
13
Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study. (20955612)
2010
14
Effects of acupuncture at 7-9 am and 3-5 pm on plasma thromboxane and prostaglandin in patients with ischemic cerebrovascular disease. (20397453)
2010
15
Role of transcranial Doppler ultrasonography in cerebrovascular disease. (19705994)
2010
16
Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention. (20370718)
2010
17
Coronary, peripheral and cerebrovascular disease: a complex relationship. (21121404)
2010
18
Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry. (19815240)
2009
19
Periodontitis and incidence of cerebrovascular disease in men. (19847898)
2009
20
The interactions between cardiovascular and cerebrovascular disease. (18793888)
2009
21
Cerebrovascular disease in childhood cancer survivors: A Children's Oncology Group Report. (19812380)
2009
22
Dietary salt, cerebrovascular disease and stomach cancer mortalities. (18372574)
2008
23
Autosomal dominant leukoencephalopathy with mild clinical symptoms due to cerebrovascular dysfunctions: a new disease entity? (17656057)
2008
24
Angioplasty and stenting for cerebrovascular disease: current status. (18790379)
2008
25
Critical appraisal of medical devices in the management of cerebrovascular disease. (18728708)
2008
26
Lack of association between variants in the VKORC1 gene and cerebrovascular or coronary heart disease. (18826394)
2008
27
Morphological variations of the internal carotid artery: Prevalence, characteristics and association with cerebrovascular disease. (22477273)
2007
28
Cerebrovascular disease and dementia: a primate model of hypertension and cognition. (19595977)
2007
29
Oxidative stress, endothelial dysfunction and cerebrovascular disease. (17971636)
2007
30
Neuropathic and cerebrovascular correlates of hearing loss in Fabry disease. (17105746)
2007
31
Protective effects of beta-blockers in cerebrovascular disease. (17296916)
2007
32
Baseline characteristics of patients with cerebrovascular disease in the REACH registry: the Spanish contribution. (17971643)
2007
33
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
34
The last 50 years of cerebrovascular disease: Part 1. (18706055)
2006
35
Commentary. Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. (16110388)
2005
36
Aldosterone: good guy or bad guy in cerebrovascular disease? (16213743)
2005
37
Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia. (15277612)
2004
38
Chlamydia pneumoniae in elderly patients with stroke (C-PEPS): a case-control study on the seroprevalence of Chlamydia pneumoniae in elderly patients with acute cerebrovascular disease. (12499705)
2003
39
Potential biological markers for cerebrovascular disease. (16191223)
2003
40
Cerebrovascular disease in systemic lupus erythematosus (SLE): lack of association with anticardiolipin (aCL) antibodies. (17041354)
2002
41
Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases. (11557685)
2001
42
Lack of association between angiotensin I-converting enzyme gene deletion polymorphism and cerebrovascular disease in Taiwanese. (11155741)
2000
43
Polymorphism in the promoter of lipopolysaccharide receptor CD14 and ischemic cerebrovascular disease. (11062291)
2000
44
Alterations in neurotransmitter, amino acid and free radical related substances in cerebrospinal fluid in patients with cerebrovascular diseases]. (10410569)
1999
45
Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma. (9731617)
1998
46
Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease. (9715796)
1998
47
Blood pressure lowering in patients with cerebrovascular disease: results of the PROGRESS (Perindopril Protection Against Recurrent Stroke Study) pilot phase. (8713688)
1996
48
Cerebrovascular complications of Fabry's disease. (8687196)
1996
49
Ischemic cerebrovascular disease and hormone therapy for infertility and transsexualism. (7644062)
1995
50
Preview of heart, cancer and cerebrovascular disease control planning. (4227395)
1966

Genetic Variations for Cerebrovascular Disease

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Expression for genes affiliated with Cerebrovascular Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebrovascular Disease

Search GEO for disease gene expression data for Cerebrovascular Disease.

Pathways for genes affiliated with Cerebrovascular Disease

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37NCBI BioSystems Database, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Cerebrovascular Disease

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1cysteine4411.2CBS, FABP2, APOE, SOD3, RECK, NOTCH3
2cholesterol44 28 11 2414.1MTHFR, FABP2, APOH, APOE, SOD3, BACE1
3lipid4411.1ADM, FABP2, SELPLG, SERPINA3, CETP, PON1
4arginine4411.1ADM, CETP, SERPINA3, NOTCH3, SOD3, CBS
5heparin44 28 11 2414.1BACE1, PON1, SERPINA3, CETP, MTHFR, APOH
6homocysteine44 2412.1APOE, APOH, SOD3, MTHFR, PON1, MTR
7folate4411.1SERPINA3, RECK, CBS, MTR, PON1, MTHFR
8alanine4411.0ADM, SOD3, APOE, SELPLG, CETP, PON1
9creatinine4411.0FABP2, MTR, MTHFR, ADM, TSPO, SERPINA3
10acetylcholine44 49 28 11 2415.0SOD3, APOE, BACE1, PON1, ACHE, SERPINA3
11serine4411.0SERPINA3, SELPLG, ACHE, CBS, BACE1, F12
12vitamin b124411.0MTHFR, MTR, PON1, APOE, APOH, CBS
13fibrinogen4411.0PON1, CBS, RECK, SELPLG, SERPINA3, APOH
14valine4411.0CETP, TSPO, SERPINA3, MTR, FABP2, APOE
15betacarotene4411.0SERPINA3, PON1, MTHFR, APOH, APOE, CETP
16estrogen4411.0F12, BACE1, TRH, CETP, APOH
17methionine4411.0SERPINA3, RECK, CBS, MTR, MTHFR, PON1
18phospholipid4411.0PON1, CETP, FABP2, APOE, APOH, BACE1
19zinc44 2412.0APOH, SOD3, FABP2, MTR, F12, BACE1
20oxygen44 2412.0CX3CR1, SERPINA3, SELPLG, BACE1, SOD3, ADM
21aspirin44 49 28 2413.9APOH, APOE, CETP, MTHFR, PON1, F12
22superoxide44 2411.9SOD3, APOH, SERPINA3, BACE1
23copper44 2411.9CBS, BACE1, APOH, MTR, SOD3
24sele4410.9PON1, CETP, MTHFR, APOE
25ascorbic acid44 2411.9CETP, MTHFR, PON1, BACE1, APOE, SOD3
26glutamate4410.9ACHE, APOH, BACE1, TRH, TSPO
27cystathionine4410.9MTR, PON1, CBS, MTHFR
28alpha tocopherol4410.9APOH
29carbohydrates4410.9APOE, CETP, SELPLG, RECK, FABP2
30sialic acid4410.9SELPLG, APOH, SERPINA3, RECK, BACE1
315,10-methenyltetrahydrofolate4410.9CBS, MTHFR, MTR
32b vitamins4410.9CBS, MTHFR, MTR
33thyroxine44 2411.9APOE, PON1, SERPINA3, TRH, CETP
34testosterone44 59 11 2413.9TSPO, CETP, APOE, ADM, MTHFR, TRH
35methylcobalamin44 2411.9MTHFR, MTR, CBS
36h2o24410.8TSPO, PON1, BACE1
375-methyltetrahydrofolate44 1111.8MTHFR, MTR, CBS
38glucose4410.8TRH, APOH, ADM, SERPINA3, RECK
39phosphatidylcholine4410.8CETP, PON1, ADM, APOH, APOE
40malondialdehyde4410.8SOD3, APOH, PON1, ADM
41nadph44 2411.8ADM, FABP2, SOD3, MTR
42vitamin a44 11 2412.7SERPINA3, PON1, FABP2, APOE, CETP
43cyclosporin a44 28 5912.7CETP, TSPO, ADM, RECK
44methotrexate44 49 1112.7SERPINA3, MTR, MTHFR, APOH, CBS
45betaine44 2411.7MTHFR, MTR, CBS
46hydrogen44 2411.6MTR, CBS, FABP2, TRH, BACE1
47methylmalonic acid44 2411.5CBS, MTR, MTHFR
48cobalamin44 2411.5MTHFR, MTR, CBS
49dopamine44 28 11 2413.4TRH, TSPO, SERPINA3
50uric acid44 2411.2SOD3, APOH

GO Terms for genes affiliated with Cerebrovascular Disease

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16Gene Ontology
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Cellular components related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:03436410.5CETP, PON1, APOH, APOE
2extracellular spaceGO:00561510.5SOD3, APOE, APOH, F12, PON1, ACHE
3chylomicronGO:04262710.5APOH, APOE
4extracellular regionGO:00557610.3APOE, F12, TRH, PON1, NOTCH3, ACHE

Biological processes related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:00664110.8CETP, APOH, APOE
2peripheral nervous system axon regenerationGO:01401210.8TSPO, APOE
3response to woundingGO:00961110.8ADM, ACHE, CX3CR1
4homocysteine metabolic processGO:05066710.7MTHFR, CBS
5very-low-density lipoprotein particle remodelingGO:03437210.7CETP, APOE
6cholesterol metabolic processGO:00820310.7CETP, PON1, APOE
7phosphatidylcholine metabolic processGO:04647010.7PON1, CETP
8positive regulation of cholesterol effluxGO:01087510.7PON1, APOE
9positive regulation of blood coagulationGO:03019410.6F12, APOH
10low-density lipoprotein particle remodelingGO:03437410.6CETP, APOE
11agingGO:00756810.5APOE, TSPO, ADM
12synaptic transmission, cholinergicGO:00727110.5ACHE, APOE
13negative regulation of blood coagulationGO:03019510.4APOH, APOE
14high-density lipoprotein particle remodelingGO:03437510.2CETP, APOE

Molecular functions related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid bindingGO:00828910.5CETP, APOH, APOE
2modified amino acid bindingGO:07234110.5CBS, MTHFR
3cholesterol transporter activityGO:01712710.4CETP, APOE
4lipid transporter activityGO:00531910.2CETP, APOE

Products for genes affiliated with Cerebrovascular Disease

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  • Antibodies
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Sources for Cerebrovascular Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet