MCID: CRB039
MIFTS: 61

Cerebrovascular Disease malady

Cardiovascular diseases category

Summaries for Cerebrovascular Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels... more...

MalaCards: Cerebrovascular Disease, also known as cerebrovascular disorders, is related to vascular disease and dementia. An important gene associated with Cerebrovascular Disease is NOTCH3 (notch 3), and among its related pathways are Selenium Pathway and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds cysteine and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Cerebrovascular Disease

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Cerebrovascular Disease

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17GeneCards, 18GeneDecks
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Diseases related to Cerebrovascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease31.0MTR, MTHFR, APOH, APOE, SOD3, PON1
2dementia30.9CETP, TSPO, SERPINA3, ACHE, NOTCH3, CBS
3alzheimer's disease30.9APOE, MTR, BACE1, PON1, CBS, RECK
4brain disease30.8TSPO, SERPINA3, NOTCH3, BACE1
5stroke, ischemic30.7APOE, MTHFR, NOTCH3, ADM
6hypertension30.7APOE, MTHFR, ADM
7vascular dementia30.6APOE, MTHFR, PON1, NOTCH3, ACHE, SERPINA3
8diabetes mellitus30.6APOE, FABP2, MTHFR, PON1, RECK, CETP
9coronary artery disease30.5CETP, SELPLG, CX3CR1, RECK, CBS, PON1
10cadasil30.4NOTCH3
11pneumonia30.4SOD3, ADM
12myocardial infarction30.3ADM, CETP, SERPINA3, SELPLG, RECK, CBS
13obesity30.3APOE, FABP2, TRH, PON1, CBS, CETP
14ischemic heart disease30.3SOD3, PON1, NOTCH3, TSPO, CETP, ADM
15migraine30.3APOH, MTHFR, NOTCH3
16ischemia30.2CBS, PON1, FABP2, SELPLG, ADM
17lupus erythematosus30.2APOH
18systemic lupus erythematosus30.2APOH, PON1, RECK, CX3CR1
19atherosclerosis30.1CETP, SELPLG, CX3CR1, RECK, CBS, PON1
20acute myocardial infarction30.1SOD3, PON1, CBS, ADM
21arthritis30.1SERPINA3, SOD3
22binswanger's disease30.1APOE, NOTCH3, ACHE
23thyroiditis30.1TRH
24cerebral amyloid angiopathy30.1PON1, APOE
25type 2 diabetes mellitus29.8APOE, FABP2, MTHFR, PON1, RECK, ACHE
26rheumatoid arthritis29.8SOD3, APOH, MTHFR, PON1, RECK, CX3CR1
27asthma29.8PON1, RECK, CX3CR1, SELPLG, SERPINA3, TSPO
28thrombophilia29.8APOH, MTHFR, F12, CBS
29parkinson's disease29.8APOE, MTR, PON1, ACHE, SERPINA3, TSPO
30prion disease29.8APOE, BACE1, ACHE, SERPINA3, TSPO
31abdominal aortic aneurysm29.8APOE
32psoriasis29.8CX3CR1, SERPINA3
33antiphospholipid syndrome29.8PON1, MTHFR, APOH
34infertility29.8PON1
35glaucoma29.8ACHE, PON1
36carotid stenosis29.8PON1
37peripheral vascular disease29.8MTHFR, CBS
38deficiency anemia29.8ADM, TRH, MTR
39cerebritis10.5
40moyamoya disease10.4
41carotid artery disease10.3
42sickle cell disease10.3
43sickle cell anemia10.3
44hemorrhagic disease10.3
45fabry disease10.3
46aneurysm disease10.2
47neurologic diseases10.2
48basal ganglia cerebrovascular disease10.1
49cerebral arteritis10.1
50cerebral atherosclerosis10.1

Graphical network of the top 20 diseases related to Cerebrovascular Disease:



Diseases related to cerebrovascular disease

Clinical Features for Cerebrovascular Disease

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Drugs & Therapeutics for Cerebrovascular Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cerebrovascular Disease

Drug clinical trials:

Search ClinicalTrials for Cerebrovascular Disease

Search NIH Clinical Center for Cerebrovascular Disease

Search CenterWatch for Cerebrovascular Disease

Genetic Tests for Cerebrovascular Disease

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Anatomical Context for Cerebrovascular Disease

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32MalaCards
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MalaCards organs/tissues related to Cerebrovascular Disease:

32
Brain, Heart, Endothelial, Testes, Smooth muscle, Pituitary, Thyroid, Kidney, Skin, T cells, Temporal lobe, Thalamus

Animal Models for Cerebrovascular Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cerebrovascular Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9ADM, SOD3, APOE, APOH, FABP2, MTHFR
2MP:001076810.8SOD3, APOE, APOH, MTHFR, MTR, BACE1
3MP:001077110.7BACE1, CBS, RECK, CX3CR1, SELPLG
4MP:000536710.6FABP2, CBS, CX3CR1, SELPLG, ADM
5MP:000363110.6MTHFR, F12, BACE1, TRH, RECK, CX3CR1
6MP:000536910.6APOE, BACE1, CBS, CX3CR1, NOTCH3, ACHE
7MP:000537810.5APOE, FABP2, MTHFR, BACE1, TRH, CBS
8MP:000539510.2APOE, BACE1, RECK, ADM

Publications for Cerebrovascular Disease

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50PubMed
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Articles related to Cerebrovascular Disease:

(show top 50)    (show all 763)
idTitleAuthorsYear
1
Cerebrovascular pathology and amyloid plaque formation in Alzheimer's disease. (24251391)
2014
2
Introduction: Management of ischemic cerebrovascular disease. (24380487)
2014
3
Incidence and clinical features of cerebrovascular disease among HIV-infected adults in the Southeastern United States. (23565888)
2013
4
Identifying core nursing sensitive outcomes associated with the most frequently used North American Nursing Diagnosis Association-International nursing diagnoses for patients with cerebrovascular disease in Korea. (24261561)
2013
5
Movement disorders in cerebrovascular disease. (23602779)
2013
6
Assessment of cerebrovascular reactivity using real-time BOLD fMRI in children with moyamoya disease: a pilot study. (23132694)
2013
7
Incidence of late cerebrovascular events after direct bypass among children with moyamoya disease: a descriptive longitudinal study at a single center. (24363147)
2013
8
Evolving role of biomarkers in acute cerebrovascular disease. (22451199)
2012
9
The interaction of aspiration pneumonia with demographic and cerebrovascular disease risk factors is predictive of discharge level of care in acute stroke patient. (22355814)
2012
10
From bench-to-bedside in catastrophic cerebrovascular disease: development of drugs targeting the endothelin axis in subarachnoid hemorrhage-related vasospasm. (22333896)
2012
11
Cerebrovascular disease in South Asia - Part II: Risk factors and prevention. (24175078)
2012
12
Developmental origins of cerebrovascular disease II: considering gene-environment interactions when developing neuroprotective strategies. (22180566)
2012
13
Cerebrovascular disease in 48 countries: secular trends in mortality 1950-2005. (22019549)
2012
14
Average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people. (22105196)
2011
15
Subclinical cerebrovascular disease in older adults. (20431076)
2010
16
A role for monomeric C-reactive protein in regulation of angiogenesis, endothelial cell inflammation and thrombus formation in cardiovascular/cerebrovascular disease? (19760596)
2009
17
Managing older patients who have neurologic disease: Alzheimer disease and cerebrovascular accident. (19269397)
2009
18
Genomics and the efficacy of aspirin in the treatment of cerebrovascular disease. (19433014)
2009
19
Unilateral hemispheric proliferation of ivy sign on fluid-attenuated inversion recovery images in moyamoya disease correlates highly with ipsilateral hemispheric decrease of cerebrovascular reserve. (19713323)
2009
20
Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation. (19292735)
2009
21
Prevalence of hypopituitarism in patients with cerebrovascular diseases. (19020380)
2008
22
The C242T polymorphism of the NAD(P)H oxidase p22phox subunit is associated with an enhanced risk for cerebrovascular disease at a young age. (18799874)
2008
23
Genetic profile of ischemic cerebrovascular disease and carotid stenosis. (18325076)
2008
24
Update on the genetics of stroke and cerebrovascular disease 2006. (17204678)
2007
25
Biomarkers of cerebrovascular disease in dementia. (18445743)
2007
26
Perindopril-based blood pressure-lowering therapy reduces amino-terminal-pro-B-type natriuretic peptide in individuals with cerebrovascular disease. (17278987)
2007
27
Pregnancy-associated plasma protein-A in patients with cerebrovascular diseases--a pilot study. (16752802)
2006
28
Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT). (17111043)
2006
29
Benefits of statins in cerebrovascular disease. (15083596)
2004
30
Diabetes mellitus and the cerebrovascular disease]. (15775195)
2003
31
ACE inhibitors and its usefulness in the prevention of aspiration pneumonia in chronic cerebrovascular disease patients with asymptomatic swallowing dysfunction]. (12474296)
2002
32
Calcitonin gene-related peptide (CGRP) in cerebrovascular disease. (12805934)
2002
33
Polymorphisms of P-selectin glycoprotein ligand-1 are associated with neutrophil-platelet adhesion and with ischaemic cerebrovascular disease. (11843835)
2001
34
The study of PAI-1 promotor region gene polymorphism in cerebrovascular disease]. (11592048)
2001
35
Lipoprotein lipase genetic variation and gender-specific ischemic cerebrovascular disease risk. (11127970)
2000
36
Study on relationship between anticardiolipin antibody and cerebrovascular diseases. (12840879)
1999
37
Apolipoprotein E phenotypes in demented and cognitively impaired patients with and without cerebrovascular disease. (10362893)
1999
38
Cerebrovascular disease in patients with HIV-1 associated pulmonary hypertension. (16873194)
1999
39
Cerebrovascular risk factors and later-life major depression. Testing a small-vessel brain disease model. (9469209)
1998
40
Assessment of benzodiazepine receptors using iodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease. A comparison with PET study. (9303025)
1997
41
Cerebrovascular changes associated with interleukin-1 beta (IL-1 beta) and histamine (HA) levels in Alzheimer's disease. (9329706)
1997
42
Types of cerebrovascular lesions associated with severe cerebral amyloid angiopathy in Alzheimer's disease. (9329731)
1997
43
Cerebrovascular complications of rheumatic disease. (9156394)
1997
44
Benzodiazepine receptors in chronic cerebrovascular disease: comparison with blood flow and metabolism. (9374335)
1997
45
Prevalence of impaired cerebrovascular reserve in patients with symptomatic carotid artery disease. (8313116)
1994
46
Beta-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. (8248178)
1993
47
Cerebrovascular disease in Ehlers-Danlos syndrome type IV. (2326845)
1990
48
Ejection fraction response of the left ventricle of the heart to acute cerebrovascular accident in patients with coronary artery disease. (3738940)
1986
49
Biometeorologie studies on cerebrovascular diseases. (IV). Evaluation of meterorologic factors, their changes or combinations on the occurrence of cerebrovascular accident. (5468294)
1970
50
Experiences with 250 cerebrovascular accident cases in a chronic disease hospital; symptomatology, diagnosis, course and treatment. (13203918)
1954

Genetic Variations for Cerebrovascular Disease

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Expression for genes affiliated with Cerebrovascular Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cerebrovascular Disease

Search GEO for disease gene expression data for Cerebrovascular Disease.

Pathways for genes affiliated with Cerebrovascular Disease

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37NCBI BioSystems Database, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Cerebrovascular Disease

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1cysteine4411.2CBS, FABP2, APOE, SOD3, RECK, NOTCH3
2cholesterol44 28 11 2414.1MTHFR, FABP2, APOH, APOE, SOD3, BACE1
3lipid4411.1ADM, FABP2, SELPLG, SERPINA3, CETP, PON1
4arginine4411.1ADM, CETP, SERPINA3, NOTCH3, SOD3, CBS
5heparin44 28 11 2414.1BACE1, PON1, SERPINA3, CETP, MTHFR, APOH
6homocysteine44 2412.1APOE, APOH, SOD3, MTHFR, PON1, MTR
7folate4411.1SERPINA3, RECK, CBS, MTR, PON1, MTHFR
8alanine4411.0ADM, SOD3, APOE, SELPLG, CETP, PON1
9creatinine4411.0FABP2, MTR, MTHFR, ADM, TSPO, SERPINA3
10acetylcholine44 49 28 11 2415.0SOD3, APOE, BACE1, PON1, ACHE, SERPINA3
11serine4411.0SERPINA3, SELPLG, ACHE, CBS, BACE1, F12
12vitamin b124411.0MTHFR, MTR, PON1, APOE, APOH, CBS
13fibrinogen4411.0PON1, CBS, RECK, SELPLG, SERPINA3, APOH
14valine4411.0CETP, TSPO, SERPINA3, MTR, FABP2, APOE
15betacarotene4411.0SERPINA3, PON1, MTHFR, APOH, APOE, CETP
16estrogen4411.0F12, BACE1, TRH, CETP, APOH
17methionine4411.0SERPINA3, RECK, CBS, MTR, MTHFR, PON1
18phospholipid4411.0PON1, CETP, FABP2, APOE, APOH, BACE1
19zinc44 2412.0APOH, SOD3, FABP2, MTR, F12, BACE1
20oxygen44 2412.0CX3CR1, SERPINA3, SELPLG, BACE1, SOD3, ADM
21aspirin44 49 28 2413.9APOH, APOE, CETP, MTHFR, PON1, F12
22superoxide44 2411.9SOD3, APOH, SERPINA3, BACE1
23copper44 2411.9CBS, BACE1, APOH, MTR, SOD3
24sele4410.9PON1, CETP, MTHFR, APOE
25ascorbic acid44 2411.9CETP, MTHFR, PON1, BACE1, APOE, SOD3
26glutamate4410.9ACHE, APOH, BACE1, TRH, TSPO
27cystathionine4410.9MTR, PON1, CBS, MTHFR
28alpha tocopherol4410.9APOH
29carbohydrates4410.9APOE, CETP, SELPLG, RECK, FABP2
30sialic acid4410.9SELPLG, APOH, SERPINA3, RECK, BACE1
315,10-methenyltetrahydrofolate4410.9CBS, MTHFR, MTR
32b vitamins4410.9CBS, MTHFR, MTR
33thyroxine44 2411.9APOE, PON1, SERPINA3, TRH, CETP
34testosterone44 59 11 2413.9TSPO, CETP, APOE, ADM, MTHFR, TRH
35methylcobalamin44 2411.9MTHFR, MTR, CBS
36h2o24410.8TSPO, PON1, BACE1
375-methyltetrahydrofolate44 1111.8MTHFR, MTR, CBS
38glucose4410.8TRH, APOH, ADM, SERPINA3, RECK
39phosphatidylcholine4410.8CETP, PON1, ADM, APOH, APOE
40malondialdehyde4410.8SOD3, APOH, PON1, ADM
41nadph44 2411.8ADM, FABP2, SOD3, MTR
42vitamin a44 11 2412.7SERPINA3, PON1, FABP2, APOE, CETP
43cyclosporin a44 28 5912.7CETP, TSPO, ADM, RECK
44methotrexate44 49 1112.7SERPINA3, MTR, MTHFR, APOH, CBS
45betaine44 2411.7MTHFR, MTR, CBS
46hydrogen44 2411.6MTR, CBS, FABP2, TRH, BACE1
47methylmalonic acid44 2411.5CBS, MTR, MTHFR
48cobalamin44 2411.5MTHFR, MTR, CBS
49dopamine44 28 11 2413.4TRH, TSPO, SERPINA3
50uric acid44 2411.2SOD3, APOH

GO Terms for genes affiliated with Cerebrovascular Disease

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16Gene Ontology
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Cellular components related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:03436410.5CETP, PON1, APOH, APOE
2extracellular spaceGO:00561510.5SOD3, APOE, APOH, F12, PON1, ACHE
3chylomicronGO:04262710.5APOH, APOE
4extracellular regionGO:00557610.3APOE, F12, TRH, PON1, NOTCH3, ACHE

Biological processes related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:00664110.8CETP, APOH, APOE
2peripheral nervous system axon regenerationGO:01401210.8TSPO, APOE
3response to woundingGO:00961110.8ADM, ACHE, CX3CR1
4homocysteine metabolic processGO:05066710.7MTHFR, CBS
5very-low-density lipoprotein particle remodelingGO:03437210.7CETP, APOE
6cholesterol metabolic processGO:00820310.7CETP, PON1, APOE
7phosphatidylcholine metabolic processGO:04647010.7PON1, CETP
8positive regulation of cholesterol effluxGO:01087510.7PON1, APOE
9positive regulation of blood coagulationGO:03019410.6F12, APOH
10low-density lipoprotein particle remodelingGO:03437410.6CETP, APOE
11agingGO:00756810.5APOE, TSPO, ADM
12synaptic transmission, cholinergicGO:00727110.5ACHE, APOE
13negative regulation of blood coagulationGO:03019510.4APOH, APOE
14high-density lipoprotein particle remodelingGO:03437510.2CETP, APOE

Molecular functions related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid bindingGO:00828910.5CETP, APOH, APOE
2modified amino acid bindingGO:07234110.5CBS, MTHFR
3cholesterol transporter activityGO:01712710.4CETP, APOE
4lipid transporter activityGO:00531910.2CETP, APOE

Products for genes affiliated with Cerebrovascular Disease

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  • Antibodies
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Sources for Cerebrovascular Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet