CVA
MCID: CRB039
MIFTS: 69

Cerebrovascular Disease (CVA) malady

Cardiovascular diseases category
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Summaries for Cerebrovascular Disease

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MedlinePlus:33 A stroke is a medical emergency. strokes happen when blood flow to your brain stops. within minutes, brain cells begin to die. there are two kinds of stroke. the more common kind, called ischemic stroke, is caused by a blood clot that blocks or plugs a blood vessel in the brain. the other kind, called hemorrhagic stroke, is caused by a blood vessel that breaks and bleeds into the brain. "mini-strokes" or transient ischemic attacks (tias), occur when the blood supply to the brain is briefly interrupted. symptoms of stroke are sudden numbness or weakness of the face, arm or leg (especially on one side of the body) sudden confusion, trouble speaking or understanding speech sudden trouble seeing in one or both eyes sudden trouble walking, dizziness, loss of balance or coordination sudden severe headache with no known cause if you have any of these symptoms, you must get to a hospital quickly to begin treatment. acute stroke therapies try to stop a stroke while it is happening by quickly dissolving the blood clot or by stopping the bleeding. post-stroke rehabilitation helps individuals overcome disabilities that result from stroke damage. drug therapy with blood thinners is the most common treatment for stroke. nih: national institute of neurological disorders and stroke

MalaCards based summary: Cerebrovascular Disease, also known as stroke, is related to vascular dementia and dementia. An important gene associated with Cerebrovascular Disease is ALOX5AP (arachidonate 5-lipoxygenase-activating protein), and among its related pathways are A-beta Uptake and Degradation and Folate Metabolism. The drugs warfarin and warfarin sodium and the compounds quinoline and kaolin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related mouse phenotypes are renal/urinary system and skeleton.

Disease Ontology:8 An artery disease that is characterized by dysfunction of the blood vessels supplying the brain.

NINDS:43 A stroke occurs when the blood supply to part of the brain is suddenly interrupted or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding brain cells. Brain cells die when they no longer receive oxygen and nutrients from the blood or there is sudden bleeding into or around the brain. The symptoms of a stroke include sudden numbness or weakness, especially on one side of the body; sudden confusion or trouble speaking or understanding speech; sudden trouble seeing in one or both eyes; sudden trouble with walking, dizziness, or loss of balance or coordination; or sudden severe headache with no known cause. There are two forms of stroke: - blockage of a blood vessel supplying the brain, and - bleeding into or around the brain.

Wikipedia:65 Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels... more...

Description from OMIM:46 601367

Aliases & Classifications for Cerebrovascular Disease

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Sources:
8Disease Ontology, 62UMLS, 44Novoseek, 43NINDS, 46OMIM, 33MedlinePlus, 57SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Cerebrovascular Disease, Aliases & Descriptions:

Name: Cerebrovascular Disease 8 44
Stroke 8 43 46 44 33
Cerebrovascular Accident 8 62
Cerebrovascular Disorders 62
 
Cerebrovascular Disorder 8
Cva, Nos 62
Cva 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Cerebrovascular Disease

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Diseases related to Cerebrovascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 851)
idRelated DiseaseScoreTop Affiliating Genes
1vascular dementia31.2APOE, NOTCH3
2dementia31.0APOE, NOTCH3, TSPO, SERPINA3
3cerebral amyloid angiopathy30.7APOE
4retinal artery occlusion30.7APOH
5alzheimer's disease30.6ALOX5AP, APOE, SERPINA3, TSPO, NOTCH3
6binswanger's disease30.6APOE, NOTCH3
7eclampsia30.5MTHFR
8pulmonary embolism30.5APOH, MTHFR
9transient cerebral ischemia30.5APOH, MTHFR, NOTCH3
10protein s deficiency30.4MTHFR, APOH
11retinal vein occlusion30.3APOH, MTHFR
12antithrombin iii deficiency30.3APOH, MTHFR
13memory impairment30.2TSPO, APOE
14stroke, ischemic30.2NOTCH3, ALOX5AP, APOE, MTHFR
15protein c deficiency30.2MTHFR, APOH
16migraine30.2APOH, MTHFR, NOTCH3
17psoriasis30.2CX3CR1, SERPINA3
18amyotrophic lateral sclerosis type 1430.2TSPO
19thrombophlebitis30.2APOH
20brain disease30.2NOTCH3, TSPO, SERPINA3
21prion disease30.1TSPO, SERPINA3, APOE
22creutzfeldt-jakob disease30.1SERPINA3, APOE, TSPO
23hemorrhage, intracerebral30.1APOE, SERPINA3
24antiphospholipid syndrome30.1APOH, MTHFR
25hypercholesterolemia30.1FABP2, SELPLG, APOE
26down syndrome30.0SERPINA3, APOE, MTHFR
27parkinson's disease29.9TSPO, APOE, SERPINA3
28factor v leiden thrombophilia29.8SERPINA3, F12, SELPLG
29thrombophilia29.7F12, APOH, MTHFR
30multiple sclerosis29.7APOE, NOTCH3, CX3CR1, TSPO, SELPLG
31multiple system atrophy29.7TSPO, SERPINA3
32hyperhomocysteinemia29.7MTHFR, SOD3, APOH, APOE
33type 2 diabetes mellitus29.7MTHFR, APOE, FABP2
34thromboembolism29.6APOH, F12, MTHFR, SERPINA3
35osteoarthritis29.5SERPINA3, CX3CR1, TSPO, ALOX5AP
36asthma29.5CX3CR1, ALOX5AP, SERPINA3, SELPLG, TSPO
37venous thrombosis29.5APOH, F12, SELPLG, MTHFR
38myocardial infarction29.3SERPINA3, SELPLG, APOE, SOD3, MTHFR, ALOX5AP
39vascular disease29.1APOH, APOE, SOD3, MTHFR, NOTCH3
40primary hyperoxaluria29.1MTHFR, APOE, SOD3
41atherosclerosis28.7SOD3, MTHFR, APOH, APOE, FABP2, ALOX5AP
42rheumatoid arthritis28.5SOD3, TSPO, MTHFR, CX3CR1, APOH, SERPINA3
43lactic acidosis10.7
44cerebral artery occlusion10.6
45mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.5
46cerebritis10.5
47atrial septal aneurysm10.5
48myopathy10.5
49peripheral vascular disease10.5
50hypertension10.5

Graphical network of the top 20 diseases related to Cerebrovascular Disease:



Diseases related to cerebrovascular disease

Symptoms for Cerebrovascular Disease

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Clinical features from OMIM:

601367

Drugs & Therapeutics for Cerebrovascular Disease

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Drug clinical trials:

Search ClinicalTrials for Cerebrovascular Disease

Search NIH Clinical Center for Cerebrovascular Disease

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cerebrovascular Disease

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Anatomical Context for Cerebrovascular Disease

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MalaCards organs/tissues related to Cerebrovascular Disease:

32
Brain, Eye, Heart, Endothelial, Testes, Kidney, Thyroid, Pituitary, Neutrophil, Smooth muscle, Skin, T cells, Temporal lobe, Thalamus

Animal Models for Cerebrovascular Disease or affiliated genes

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MGI Mouse Phenotypes related to Cerebrovascular Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7APOE, SELPLG, FABP2, CX3CR1, NOTCH3
2MP:00053908.2APOE, SOD3, MTHFR, ALOX5AP, NOTCH3
3MP:00107718.2APOE, SELPLG, CX3CR1, MTHFR, NOTCH3
4MP:00053877.9NOTCH3, ALOX5AP, CX3CR1, SOD3, SELPLG, APOE
5MP:00107686.9APOE, APOH, SELPLG, SOD3, CX3CR1, MTHFR
6MP:00053766.1NOTCH3, F12, APOE, APOH, SELPLG, SOD3

Publications for Cerebrovascular Disease

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Articles related to Cerebrovascular Disease:

(show top 50)    (show all 675)
idTitleAuthorsYear
1
Voxel-based correlation between whole-brain CT perfusion with 320-row area detector ct and iodine 123 iodoamphetamine brain perfusion spect in patients with cerebrovascular disease. (25007339)
2014
2
Association of alpha-thalassemia, TNF-alpha (-308G>A) and VCAM-1 (c.1238G>C) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 children with sickle cell anemia. (25175566)
2014
3
Association of fasting glucose with subclinical cerebrovascular disease in older adults without Type 2 diabetes. (24344757)
2013
4
Hemodynamics and changes after STA-MCA anastomosis in moyamoya disease and atherosclerotic cerebrovascular disease measured by micro-Doppler ultrasonography. (23192651)
2013
5
Subclinical left ventricular dysfunction and silent cerebrovascular disease: the Cardiovascular Abnormalities and Brain Lesions (CABL) study. (23902759)
2013
6
Long-term survival of ischemic cerebrovascular disease in the acute inflammatory stroke study, a hospital-based cohort described by TOAST and ASCO. (23466736)
2013
7
LA volumes and reservoir function are associated with subclinical cerebrovascular disease: the CABL (Cardiovascular Abnormalities and Brain Lesions) study. (23473112)
2013
8
Assessment of Stroke and Concomitant Cerebrovascular Disease with Heart Disease Requires Invasive Treatment: Analysis of 249 Consecutive Patients with Heart Disease. (24065603)
2013
9
Diabetes mellitus and cerebrovascular disease as independent determinants for increased hospital costs and length of stay in open appendectomy in comparison with laparoscopic appendectomy: a nationwide cohort study. (22524772)
2012
10
Letter by castilla-guerra and fernandez-moreno regarding article, "average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people". (22689938)
2012
11
Evolving role of biomarkers in acute cerebrovascular disease. (22451199)
2012
12
Novel MRI approaches for assessing cerebral hemodynamics in ischemic cerebrovascular disease. (22343644)
2012
13
The effectiveness of smoking cessation interventions in smokers with cerebrovascular disease: a systematic review. (23263022)
2012
14
Concurrent Koro and Cotard syndromes in a Spanish male patient with a psychotic depression and cerebrovascular disease. (22310658)
2012
15
A multidisciplinary stroke clinic for outpatient care of veterans with cerebrovascular disease. (21594062)
2011
16
Oxidative stress and endothelial dysfunction in cerebrovascular disease. (21196259)
2011
17
A genome-wide study of moyamoya-type cerebrovascular disease in the korean population. (22323933)
2011
18
The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study. (20677172)
2011
19
Prevalence of radiological and clinical cerebrovascular disease in idiopathic Parkinson's disease. (21689880)
2011
20
Diabetes, hyperglycemia and the management of cerebrovascular disease. (21124220)
2011
21
Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. (21387371)
2011
22
Hepatitis C virus infection and increased risk of cerebrovascular disease. (20966408)
2010
23
Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort. (20457955)
2010
24
Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study. (20955612)
2010
25
The structural and functional consequences of diurnal variations in blood pressure in treated patients with hypertensive cerebrovascular disease. (19337131)
2009
26
Diabetes mellitus and cerebrovascular disease: which are the actual data? (18358748)
2009
27
CD14 C260T promoter polymorphism and the risk of cerebrovascular diseases: a meta-analysis. (19433913)
2009
28
Prophylactic, endovascularly based, long-term normothermia in ICU patients with severe cerebrovascular disease: bicenter prospective, randomized trial. (19762706)
2009
29
The association of obesity and cerebrovascular disease in young adults--a pilot study. (20055251)
2009
30
Retinal vascular signs and cerebrovascular disease. (19426407)
2009
31
Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry. (19815240)
2009
32
A role for monomeric C-reactive protein in regulation of angiogenesis, endothelial cell inflammation and thrombus formation in cardiovascular/cerebrovascular disease? (19760596)
2009
33
Aspirin resistance determined with PFA-100 does not predict new thrombotic events in patients with stable ischemic cerebrovascular disease. (19084329)
2009
34
Prevalence of hypopituitarism in patients with cerebrovascular diseases. (19020380)
2008
35
Update on the genetics of stroke and cerebrovascular disease 2007. (18187682)
2008
36
Galantamine for the treatment of BPSD in Thai patients with possible Alzheimer's disease with or without cerebrovascular disease. (18845693)
2008
37
Can the detection of misery perfusion in chronic cerebrovascular disease be based on reductions in baseline CBF and vasoreactivity? (16896662)
2007
38
Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. (17568241)
2007
39
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
40
Commentary. Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. (16110388)
2005
41
Association of the apolipoprotein A-IV: 360 Gln/His polymorphism with cerebrovascular disease, obesity, and depression in a Brazilian elderly population. (15806598)
2005
42
Factor V Leiden mutation in cerebrovascular disease. (16015421)
2005
43
Benefits of statins in cerebrovascular disease. (15083596)
2004
44
123I-FP-CIT SPECT imaging of dopamine transporters in patients with cerebrovascular disease and clinical diagnosis of vascular parkinsonism. (15471834)
2004
45
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. (11965273)
2002
46
Polymorphisms of P-selectin glycoprotein ligand-1 are associated with neutrophil-platelet adhesion and with ischaemic cerebrovascular disease. (11843835)
2001
47
Statins and cerebrovascular disease: plaque attack to prevent brain attack. (10613632)
1999
48
Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma. (8523390)
1995
49
Serum aldolase isozyme levels in patients with cerebrovascular diseases. (2240017)
1990
50
Biometeorologic studies on cerebrovascular diseases. I. Effects of meteorologic factors on the death from cerebrovascular accident. (5395972)
1969

Variations for Cerebrovascular Disease

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Expression for genes affiliated with Cerebrovascular Disease

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Expression patterns in normal tissues for genes affiliated with Cerebrovascular Disease

Search GEO for disease gene expression data for Cerebrovascular Disease.

Pathways for genes affiliated with Cerebrovascular Disease

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Pathways related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CX3CR1, APOE
2
Show member pathways
Vitamin B12 Metabolism37
8.8MTHFR, SOD3, APOE
3
Show member pathways
thioredoxin pathway37
8.6ALOX5AP, MTHFR, SOD3, SERPINA3

Compounds for genes affiliated with Cerebrovascular Disease

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Compounds related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1quinoline4410.1ALOX5AP, TSPO
2kaolin449.9F12, APOH
3sele449.9APOE, MTHFR
422r-hydroxycholesterol44 2810.9TSPO, APOE
5thiamine44 2 24 1112.9TSPO, APOE
6linoleic acid28 44 2411.8CX3CR1, FABP2, ALOX5AP
7isoflurane50 44 1111.8TSPO, SELPLG
8vitamin a44 24 1111.7APOE, FABP2, SERPINA3
9spec-t449.7TSPO, APOE
10fenofibrate44 50 1111.7APOE, FABP2
11carbohydrates449.6APOE, SELPLG, FABP2
12indomethacin44 28 61 1112.5ALOX5AP, TSPO, APOE
13sialic acid449.5SERPINA3, SELPLG, APOH
14warfarin44 50 24 1112.4APOE, APOH, MTHFR
15disulfiram44 50 61 1112.3TSPO, MTHFR
16methotrexate50 44 1111.3SERPINA3, APOH, MTHFR
17urea44 24 1111.3FABP2, SERPINA3, SOD3
18histamine44 28 2411.2ALOX5AP, TSPO, SELPLG
19phospholipid449.1APOH, APOE, FABP2
20phenytoin44 50 28 1112.1TSPO, MTHFR
21dopamine44 28 24 1112.1MTHFR, TSPO, SERPINA3, APOE
22vitamin b12449.1MTHFR, SERPINA3, APOH, APOE
23betacarotene449.1SERPINA3, MTHFR, APOH, APOE
24methionine449.0MTHFR, SOD3, SERPINA3
25ascorbic acid44 2410.0APOE, SOD3, MTHFR
26uric acid44 249.9MTHFR, SOD3, APOH
27acetylcholine44 50 28 24 1112.9TSPO, SOD3, SERPINA3, APOE
28iron44 249.8ALOX5AP, SERPINA3, SOD3, APOH
29aspirin44 50 28 2411.8ALOX5AP, MTHFR, APOH, APOE, F12
30nadph44 249.8MTHFR, SOD3, SERPINA3, FABP2
31vitamin d448.8SOD3, FABP2, MTHFR, APOE
32fibrinogen448.7MTHFR, SERPINA3, SELPLG, APOH, F12
33glutamate448.6MTHFR, APOE, APOH, TSPO
34alpha tocopherol448.6MTHFR, APOE, APOH, SOD3
35homocysteine44 249.6APOE, APOH, SOD3, MTHFR
36vegf448.6APOH, SOD3, APOE, CX3CR1
37calcium44 50 24 1111.5CX3CR1, SERPINA3, NOTCH3, APOH, SELPLG, ALOX5AP
38zinc44 249.4FABP2, F12, APOH, SERPINA3, SOD3
39oxygen44 249.3CX3CR1, APOH, SOD3, SERPINA3, SELPLG
40folate448.3APOH, APOE, SOD3, MTHFR, SERPINA3
41estrogen448.2APOE, F12, APOH, SERPINA3, TSPO, MTHFR
42valine448.2SERPINA3, MTHFR, TSPO, FABP2, APOH, APOE
43creatinine448.2APOE, SERPINA3, APOH, MTHFR, TSPO, FABP2
44serine448.1APOE, SELPLG, SERPINA3, F12, SOD3, MTHFR
45alanine448.0MTHFR, APOE, SELPLG, SERPINA3, SOD3, FABP2
46arginine448.0APOE, TSPO, NOTCH3, APOH, SOD3, SERPINA3
47cysteine447.7APOE, SELPLG, SERPINA3, SOD3, FABP2, MTHFR
48lipid447.7SELPLG, SERPINA3, ALOX5AP, FABP2, SOD3, APOH
49heparin44 28 24 1110.5MTHFR, F12, APOE, SOD3, APOH, SELPLG
50cholesterol44 28 24 1110.4SOD3, APOH, SELPLG, SERPINA3, FABP2, MTHFR

GO Terms for genes affiliated with Cerebrovascular Disease

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Cellular components related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.5APOH, APOE
2very-low-density lipoprotein particleGO:0343619.4APOH, APOE
3high-density lipoprotein particleGO:0343649.2APOE, APOH
4extracellular regionGO:0055768.4NOTCH3, SOD3, SERPINA3, APOE, F12

Biological processes related to Cerebrovascular Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:0140129.7APOE, TSPO
2positive regulation of blood coagulationGO:0301949.6F12, APOH
3negative regulation of blood coagulationGO:0301959.5APOH, APOE
4blood coagulation, intrinsic pathwayGO:0075979.5F12, APOH
5negative regulation of angiogenesisGO:0165259.5CX3CR1, APOH
6negative regulation of endothelial cell proliferationGO:0019379.4APOE, APOH
7triglyceride metabolic processGO:0066419.2APOE, APOH

Molecular functions related to Cerebrovascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082018.7SOD3, APOH, APOE
2protein bindingGO:0055156.4NOTCH3, F12, APOE, APOH, SELPLG, SERPINA3

Products for genes affiliated with Cerebrovascular Disease

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Sources for Cerebrovascular Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet