MCID: CRB039
MIFTS: 59

Cerebrovascular Disease malady

Cardiovascular diseases category

Summaries for Cerebrovascular Disease

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Wikipedia:63 Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels... more...

MalaCards based summary: Cerebrovascular Disease, also known as cerebrovascular accident, is related to vascular dementia and peripheral vascular disease. An important gene associated with Cerebrovascular Disease is SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3), and among its related pathways are A-beta Uptake and Degradation and Folate-Alcohol and Cancer Pathway. The drugs warfarin and warfarin sodium and the compounds kaolin and 22r-hydroxycholesterol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial, and related mouse phenotypes are renal/urinary system and reproductive system.

Disease Ontology:9 An artery disease that is characterized by dysfunction of the blood vessels supplying the brain.

Aliases & Classifications for Cerebrovascular Disease

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Sources:
9Disease Ontology, 60UMLS, 43Novoseek, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 25ICD10
See all sources

Cerebrovascular Disease, Aliases & Descriptions:

Name: Cerebrovascular Disease 9 43
Cerebrovascular Accident 9 60
Cerebrovascular Disorders 60
 
Cerebrovascular Disorder 9
Stroke 9
Cva 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Cerebrovascular Disease

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Diseases related to Cerebrovascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 837)
idRelated DiseaseScoreTop Affiliating Genes
1vascular dementia31.2NOTCH3, APOE
2peripheral vascular disease30.8MTHFR, CBS
3cerebral amyloid angiopathy30.8APOE
4dementia30.7NOTCH3, APOE, CBS, SERPINA3, TSPO
5retinal artery occlusion30.7APOH
6binswanger's disease30.6NOTCH3, APOE
7stroke, ischemic30.6NOTCH3, MTHFR, APOE
8protein c deficiency30.5MTHFR, APOH
9transient cerebral ischemia30.5MTHFR, APOH, NOTCH3
10protein s deficiency30.5APOH, MTHFR
11antiphospholipid syndrome30.5APOH, MTHFR
12coronary artery disease30.4NOTCH3, SOD3, TSPO
13eclampsia30.4MTHFR
14hemorrhage, intracerebral30.3APOE, SERPINA3
15pulmonary embolism30.3CBS, MTHFR, APOH
16creutzfeldt-jakob disease30.2APOE, SERPINA3, TSPO
17migraine30.2NOTCH3, MTHFR, APOH
18alzheimer disease30.2SERPINA3, CBS, APOE, NOTCH3, TSPO
19amyotrophic lateral sclerosis 130.2TSPO
20brain disease30.2TSPO, SERPINA3, NOTCH3
21thrombophlebitis30.2APOH
22homocysteinemia30.2MTHFR, CBS
23homocystinuria30.1CBS, MTHFR
24prion disease30.1TSPO, APOE, SERPINA3
25asthma29.8CX3CR1, TSPO, SERPINA3, SELPLG
26factor v leiden thrombophilia29.8SERPINA3, SELPLG, F12
27multiple system atrophy29.8SERPINA3, TSPO
28hyperhomocysteinemia29.8MTHFR, CBS, APOH, APOE, SOD3
29down syndrome29.7SERPINA3, APOE, CBS, MTHFR
30huntington disease29.7SERPINA3, CBS, TSPO
31parkinson disease, late-onset29.7APOE, TSPO, SERPINA3
32retinal vein occlusion29.7MTHFR, APOH
33osteoarthritis29.5SERPINA3, TSPO, CX3CR1
34thrombophilia29.4CBS, MTHFR, F12, APOH
35multiple sclerosis, disease progression, modifier of29.4APOE, SELPLG, NOTCH3, CX3CR1, TSPO
36myocardial infarction29.4SOD3, APOE, SELPLG, SERPINA3, CBS, MTHFR
37rheumatoid arthritis28.9TSPO, SERPINA3, APOH, MTHFR, CX3CR1, SOD3
38vascular disease28.8APOH, APOE, NOTCH3, MTHFR, CBS, SOD3
39atherosclerosis28.7MTHFR, APOE, APOH, SELPLG, SOD3, CX3CR1
40spasticity10.8
41neonatal stroke10.7
42lactic acidosis10.7
43aphasia10.7
44central post-stroke pain10.6
45hemiplegia10.6
46dysphagia10.6
47mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.6
48encephalomyopathy10.6
49mitochondrial encephalomyopathy10.6
50cerebral artery occlusion10.6

Graphical network of the top 20 diseases related to Cerebrovascular Disease:



Diseases related to cerebrovascular disease

Symptoms for Cerebrovascular Disease

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Drugs & Therapeutics for Cerebrovascular Disease

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Drug clinical trials:

Search ClinicalTrials for Cerebrovascular Disease

Search NIH Clinical Center for Cerebrovascular Disease

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Cerebrovascular Disease

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Anatomical Context for Cerebrovascular Disease

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MalaCards organs/tissues related to Cerebrovascular Disease:

31
Brain, Heart, Endothelial, Testes, Thyroid, Neutrophil, Kidney, Pituitary, Smooth muscle, Skin, T cells, Temporal lobe, Thalamus

Animal Models for Cerebrovascular Disease or affiliated genes

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MGI Mouse Phenotypes related to Cerebrovascular Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3APOE, SELPLG, FABP2, CBS, CX3CR1, NOTCH3
2MP:00053897.9APOE, CBS, CX3CR1, MTHFR, NOTCH3
3MP:00053877.9APOE, SELPLG, SOD3, CBS, CX3CR1, NOTCH3
4MP:00107717.8APOE, SELPLG, CBS, CX3CR1, MTHFR, NOTCH3
5MP:00053787.8NOTCH3, MTHFR, CX3CR1, CBS, FABP2, APOE
6MP:00107686.6APOE, APOH, SELPLG, SOD3, CBS, CX3CR1
7MP:00053766.1NOTCH3, F12, APOE, APOH, SELPLG, SOD3

Publications for Cerebrovascular Disease

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Articles related to Cerebrovascular Disease:

(show top 50)    (show all 690)
idTitleAuthorsYear
1
Nocturnal heart rate and cerebrovascular disease. (25876829)
2015
2
Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. (24375839)
2014
3
Voxel-based correlation between whole-brain CT perfusion with 320-row area detector ct and iodine 123 iodoamphetamine brain perfusion spect in patients with cerebrovascular disease. (25007339)
2014
4
Association of alpha-thalassemia, TNF-alpha (-308G>A) and VCAM-1 (c.1238G>C) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 children with sickle cell anemia. (25175566)
2014
5
Association of fasting glucose with subclinical cerebrovascular disease in older adults without Type 2 diabetes. (24344757)
2013
6
Hemodynamics and changes after STA-MCA anastomosis in moyamoya disease and atherosclerotic cerebrovascular disease measured by micro-Doppler ultrasonography. (23192651)
2013
7
Subclinical left ventricular dysfunction and silent cerebrovascular disease: the Cardiovascular Abnormalities and Brain Lesions (CABL) study. (23902759)
2013
8
Long-term survival of ischemic cerebrovascular disease in the acute inflammatory stroke study, a hospital-based cohort described by TOAST and ASCO. (23466736)
2013
9
LA volumes and reservoir function are associated with subclinical cerebrovascular disease: the CABL (Cardiovascular Abnormalities and Brain Lesions) study. (23473112)
2013
10
Assessment of Stroke and Concomitant Cerebrovascular Disease with Heart Disease Requires Invasive Treatment: Analysis of 249 Consecutive Patients with Heart Disease. (24065603)
2013
11
Diabetes mellitus and cerebrovascular disease as independent determinants for increased hospital costs and length of stay in open appendectomy in comparison with laparoscopic appendectomy: a nationwide cohort study. (22524772)
2012
12
Letter by castilla-guerra and fernandez-moreno regarding article, "average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people". (22689938)
2012
13
Evolving role of biomarkers in acute cerebrovascular disease. (22451199)
2012
14
Novel MRI approaches for assessing cerebral hemodynamics in ischemic cerebrovascular disease. (22343644)
2012
15
The effectiveness of smoking cessation interventions in smokers with cerebrovascular disease: a systematic review. (23263022)
2012
16
Concurrent Koro and Cotard syndromes in a Spanish male patient with a psychotic depression and cerebrovascular disease. (22310658)
2012
17
A multidisciplinary stroke clinic for outpatient care of veterans with cerebrovascular disease. (21594062)
2011
18
Oxidative stress and endothelial dysfunction in cerebrovascular disease. (21196259)
2011
19
A genome-wide study of moyamoya-type cerebrovascular disease in the korean population. (22323933)
2011
20
The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study. (20677172)
2011
21
Prevalence of radiological and clinical cerebrovascular disease in idiopathic Parkinson's disease. (21689880)
2011
22
Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. (21387371)
2011
23
Hepatitis C virus infection and increased risk of cerebrovascular disease. (20966408)
2010
24
Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort. (20457955)
2010
25
Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study. (20955612)
2010
26
The structural and functional consequences of diurnal variations in blood pressure in treated patients with hypertensive cerebrovascular disease. (19337131)
2009
27
Diabetes mellitus and cerebrovascular disease: which are the actual data? (18358748)
2009
28
CD14 C260T promoter polymorphism and the risk of cerebrovascular diseases: a meta-analysis. (19433913)
2009
29
Prophylactic, endovascularly based, long-term normothermia in ICU patients with severe cerebrovascular disease: bicenter prospective, randomized trial. (19762706)
2009
30
The association of obesity and cerebrovascular disease in young adults--a pilot study. (20055251)
2009
31
Retinal vascular signs and cerebrovascular disease. (19426407)
2009
32
Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry. (19815240)
2009
33
A role for monomeric C-reactive protein in regulation of angiogenesis, endothelial cell inflammation and thrombus formation in cardiovascular/cerebrovascular disease? (19760596)
2009
34
Aspirin resistance determined with PFA-100 does not predict new thrombotic events in patients with stable ischemic cerebrovascular disease. (19084329)
2009
35
Prevalence of hypopituitarism in patients with cerebrovascular diseases. (19020380)
2008
36
Update on the genetics of stroke and cerebrovascular disease 2007. (18187682)
2008
37
Galantamine for the treatment of BPSD in Thai patients with possible Alzheimer's disease with or without cerebrovascular disease. (18845693)
2008
38
Can the detection of misery perfusion in chronic cerebrovascular disease be based on reductions in baseline CBF and vasoreactivity? (16896662)
2007
39
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
40
Commentary. Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. (16110388)
2005
41
Association of the apolipoprotein A-IV: 360 Gln/His polymorphism with cerebrovascular disease, obesity, and depression in a Brazilian elderly population. (15806598)
2005
42
Factor V Leiden mutation in cerebrovascular disease. (16015421)
2005
43
Benefits of statins in cerebrovascular disease. (15083596)
2004
44
123I-FP-CIT SPECT imaging of dopamine transporters in patients with cerebrovascular disease and clinical diagnosis of vascular parkinsonism. (15471834)
2004
45
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. (11965273)
2002
46
Polymorphisms of P-selectin glycoprotein ligand-1 are associated with neutrophil-platelet adhesion and with ischaemic cerebrovascular disease. (11843835)
2001
47
Statins and cerebrovascular disease: plaque attack to prevent brain attack. (10613632)
1999
48
Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma. (8523390)
1995
49
Serum aldolase isozyme levels in patients with cerebrovascular diseases. (2240017)
1990
50
Biometeorologic studies on cerebrovascular diseases. I. Effects of meteorologic factors on the death from cerebrovascular accident. (5395972)
1969

Variations for Cerebrovascular Disease

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Expression for genes affiliated with Cerebrovascular Disease

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Search GEO for disease gene expression data for Cerebrovascular Disease.

Pathways for genes affiliated with Cerebrovascular Disease

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Pathways related to Cerebrovascular Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CX3CR1, APOE
29.1MTHFR, CBS
3
Show member pathways
Vitamin B12 Metabolism36
8.7APOE, SOD3, MTHFR
4
Show member pathways
thioredoxin pathway36
8.2MTHFR, CBS, SOD3, SERPINA3

Compounds for genes affiliated with Cerebrovascular Disease

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Sources:
43Novoseek, 28IUPHAR, 24HMDB, 12DrugBank, 49PharmGKB
See all sources

Compounds related to Cerebrovascular Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1kaolin4310.0F12, APOH
222r-hydroxycholesterol43 2810.8APOE, TSPO
311-dehydrothromboxane b2439.7CBS, APOH
4carbohydrates439.5APOE, SELPLG, FABP2
5sele439.5MTHFR, APOE
6sialic acid439.5APOH, SELPLG, SERPINA3
75,10-methenyltetrahydrofolate439.5CBS, MTHFR
8methylcobalamin43 2410.5CBS, MTHFR
9b vitamins439.5CBS, MTHFR
10Pyridoxine24 1210.5MTHFR, CBS
11urea43 24 1211.5FABP2, SOD3, SERPINA3
125-methyltetrahydrofolate43 1210.4CBS, MTHFR
13betaine43 2410.3CBS, MTHFR
14cystathionine439.2MTHFR, CBS
15warfarin43 49 24 1212.2APOE, APOH, MTHFR
16acetylcholine43 49 28 24 1213.2APOE, SERPINA3, SOD3, TSPO
17methylmalonic acid43 2410.1MTHFR, CBS
18cobalamin43 2410.0CBS, MTHFR
19copper43 2410.0CBS, SOD3, APOH
20betacarotene438.9APOE, APOH, SERPINA3, MTHFR
21p002438.9MTHFR, CBS, APOH
22dopamine43 28 24 1211.9APOE, SERPINA3, TSPO, MTHFR
23aspirin43 49 28 2411.9F12, APOE, APOH, MTHFR
24uric acid43 249.9MTHFR, SOD3, APOH
25iron43 249.9APOH, SERPINA3, SOD3, CBS
26superoxide43 249.8CBS, SOD3, SERPINA3, APOH
27methotrexate49 43 1210.7MTHFR, CBS, SERPINA3, APOH
28nadph43 249.7SERPINA3, SOD3, FABP2, MTHFR
29vitamin d438.7APOE, SOD3, FABP2, MTHFR
30methionine438.6MTHFR, CBS, SOD3, SERPINA3
31alpha tocopherol438.6APOE, APOH, SOD3, MTHFR
32vitamin b12438.4APOE, APOH, SERPINA3, CBS, MTHFR
33zinc43 249.3F12, APOH, SERPINA3, SOD3, FABP2, CBS
34h2o2438.2TSPO, CBS, SOD3, APOE
35oxygen43 249.2APOH, SELPLG, SERPINA3, SOD3, CBS, CX3CR1
36glutamate438.2MTHFR, TSPO, CBS, APOH, APOE
37estrogen438.2F12, APOE, APOH, SERPINA3, TSPO, MTHFR
38calcium43 49 24 1211.2SELPLG, SERPINA3, CBS, CX3CR1, NOTCH3, APOH
39valine438.1APOE, APOH, SERPINA3, FABP2, TSPO, MTHFR
40creatinine438.1APOE, APOH, SERPINA3, FABP2, TSPO, MTHFR
41homocysteine43 249.1APOE, APOH, SOD3, CBS, MTHFR
42fibrinogen438.1F12, APOH, SELPLG, SERPINA3, CBS, MTHFR
43alanine438.0APOE, SELPLG, SERPINA3, SOD3, FABP2, MTHFR
44arginine437.9APOE, APOH, SERPINA3, SOD3, CBS, TSPO
45lipid437.8APOE, APOH, SELPLG, SERPINA3, SOD3, FABP2
46folate437.8APOE, APOH, SERPINA3, SOD3, CBS, MTHFR
47heparin43 28 24 1210.6F12, APOE, APOH, SELPLG, SERPINA3, SOD3
48serine437.6F12, APOE, SELPLG, SERPINA3, SOD3, CBS
49cysteine437.3APOE, SELPLG, SERPINA3, SOD3, FABP2, CBS
50cholesterol43 28 24 1210.0MTHFR, APOE, APOH, SELPLG, SERPINA3, SOD3

GO Terms for genes affiliated with Cerebrovascular Disease

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Cellular components related to Cerebrovascular Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:00426279.6APOH, APOE
2very-low-density lipoprotein particleGO:00343619.5APOH, APOE
3high-density lipoprotein particleGO:00343649.3APOE, APOH
4extracellular regionGO:00055768.7NOTCH3, SOD3, SERPINA3, APOE, F12

Biological processes related to Cerebrovascular Disease according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:00140129.9TSPO, APOE
2positive regulation of blood coagulationGO:00301949.8APOH, F12
3negative regulation of blood coagulationGO:00301959.7APOE, APOH
4blood coagulation, intrinsic pathwayGO:00075979.7APOH, F12
5negative regulation of angiogenesisGO:00165259.6CX3CR1, APOH
6negative regulation of endothelial cell proliferationGO:00019379.5APOH, APOE
7triglyceride metabolic processGO:00066419.3APOH, APOE
8homocysteine metabolic processGO:00506679.3MTHFR, CBS
9response to folic acidGO:00515939.2MTHFR, CBS

Molecular functions related to Cerebrovascular Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1modified amino acid bindingGO:00723419.0MTHFR, CBS
2heparin bindingGO:00082019.0SOD3, APOH, APOE
3protein bindingGO:00055156.6F12, APOE, APOH, SELPLG, SERPINA3, SOD3

Products for genes affiliated with Cerebrovascular Disease

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  • Antibodies
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Sources for Cerebrovascular Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet