MCID: CRV030
MIFTS: 33

Cervical Adenitis

Categories: Immune diseases

Aliases & Classifications for Cervical Adenitis

MalaCards integrated aliases for Cervical Adenitis:

Name: Cervical Adenitis 12 14
Cervical Lymphadenitis 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4637
NCIt 46 C26937
SNOMED-CT 64 3502005
UMLS 69 C0149642

Summaries for Cervical Adenitis

MalaCards based summary : Cervical Adenitis, also known as cervical lymphadenitis, is related to stomatitis and aphthous stomatitis. An important gene associated with Cervical Adenitis is CARD8 (Caspase Recruitment Domain Family Member 8), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Hematopoietic cell lineage. The drugs Antibodies and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, monocytes and tonsil.

Related Diseases for Cervical Adenitis

Diseases related to Cervical Adenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 stomatitis 30.8 IL1B MEFV
2 aphthous stomatitis 30.5 IL1B MEFV NLRP3
3 pharyngitis 30.2 CARD8 FCGR1A IL1B MEFV
4 periodic fever, aphthous stomatitis, pharyngitis and adenitis 11.3
5 cervicitis 10.8
6 systemic onset juvenile idiopathic arthritis 10.2 IL1B MEFV
7 tinea favosa 10.2 IL1B NLRP3
8 vulvar vestibulitis syndrome 10.2 IL1B NLRP3
9 schnitzler syndrome 10.2 IL1B NLRP3
10 chronic recurrent multifocal osteomyelitis 10.1 IL1B NLRP3
11 hydrarthrosis 10.1 IL1B MEFV
12 aseptic meningitis 10.1 IL1B NLRP3
13 specific bursitis often of occupational origin 10.1 FCGR1A MEFV
14 familial cold autoinflammatory syndrome 10.1 IL1B NLRP3
15 olecranon bursitis 10.1 FCGR1A MEFV
16 adult-onset still's disease 10.1 IL1B MEFV
17 psoriatic juvenile idiopathic arthritis 10.1 MEFV NLRP3
18 palindromic rheumatism 10.1 IL1B MEFV
19 pericarditis 10.1 IL1B MEFV
20 erysipeloid 10.1 MEFV NLRP3
21 silicosis 10.1 IL1B NLRP3
22 pneumoconiosis 10.1 IL1B NLRP3
23 primary bacterial infectious disease 10.0 IL1B MEFV
24 bone inflammation disease 10.0 IL1B NLRP3
25 hypersensitivity reaction disease 10.0 IL1B MEFV
26 mycobacterium tuberculosis 1 10.0
27 relapsing fever 10.0 MEFV MVK
28 peritonitis 9.9 IL1B MEFV
29 suppurative otitis media 9.9 HSF4 IL1B
30 nasopharyngeal carcinoma 9.9
31 glomerulonephritis 9.9
32 tonsillitis 9.9
33 nasopharyngitis 9.9
34 mycobacterium malmoense 9.9
35 gout 9.9 IL1B NLRP3
36 immune system disease 9.8 IL1B MEFV
37 familial cold autoinflammatory syndrome 1 9.8 IL1B MEFV NLRP3
38 muckle-wells syndrome 9.8 IL1B MEFV NLRP3
39 wells syndrome 9.8 IL1B MEFV NLRP3
40 human immunodeficiency virus type 1 9.8
41 kawasaki disease 9.8
42 episodic pain syndrome, familial, 1 9.8
43 acute cervicitis 9.8
44 brucellosis 9.8
45 cat-scratch disease 9.8
46 intermediate uveitis 9.8
47 uveitis 9.8
48 hyperparathyroidism 9.8
49 toxic shock syndrome 9.8
50 chronic cervicitis 9.8

Graphical network of the top 20 diseases related to Cervical Adenitis:



Diseases related to Cervical Adenitis

Symptoms & Phenotypes for Cervical Adenitis

Drugs & Therapeutics for Cervical Adenitis

Drugs for Cervical Adenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1
2 Antibodies, Monoclonal Phase 1
3 Immunoglobulins Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Withdrawn NCT02535962 Phase 2
2 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Not yet recruiting NCT02775994 Phase 1 Canakinumab

Search NIH Clinical Center for Cervical Adenitis

Genetic Tests for Cervical Adenitis

Anatomical Context for Cervical Adenitis

MalaCards organs/tissues related to Cervical Adenitis:

38
Neutrophil, Monocytes, Tonsil, Lymph Node

Publications for Cervical Adenitis

Articles related to Cervical Adenitis:

(show top 50) (show all 123)
# Title Authors Year
1
Diagnostic Criteria for Adult-Onset Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome. ( 28970828 )
2017
2
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children. ( 28343210 )
2017
3
Evolving Frontiers in the Treatment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Syndrome. ( 28786261 )
2017
4
Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome. ( 28137891 )
2017
5
Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants? ( 28207965 )
2017
6
INTERMEDIATE UVEITIS ASSOCIATED WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND CERVICAL ADENITIS SYNDROME. ( 28570435 )
2017
7
Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28271158 )
2017
8
Unraveling the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis through genetic, immunologic, and microbiologic discoveries: an update. ( 28557837 )
2017
9
Unique histologic features of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28748511 )
2017
10
Review of autoinflammatory diseases, with a special focus on periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. ( 27426283 )
2016
11
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome: a Review of the Pathogenesis. ( 26984802 )
2016
12
Tuberculosis Cervical Adenitis: Management Dilemmas. ( 27273690 )
2016
13
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) syndrome: analysis of patients from two geographic areas. ( 27059542 )
2016
14
Is colchicine an effective treatment in periodic fever, aphtous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome? ( 27068612 )
2016
15
The Pathogenesis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: A Review of Current Research. ( 26457006 )
2015
16
Reduced number of CD8+ cells in tonsillar germinal centers in children with the Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. ( 25882211 )
2015
17
Analysis of the genetic basis of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 25988833 )
2015
18
Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome. ( 26315860 )
2015
19
Vitamin D levels and effects of vitamin D replacement in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 24746456 )
2014
20
Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Syndrome in Iranian Children First Report of Iranian Periodic Fever and Autoinflammatory Registry (IPFAIR). ( 25793068 )
2014
21
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). ( 25209127 )
2014
22
International periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome cohort: description of distinct phenotypes in 301 patients. ( 24505122 )
2014
23
Markedly elevated CD64 expressions on neutrophils and monocytes are useful for diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome during flares. ( 24623459 )
2014
24
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system. ( 24134207 )
2013
25
Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1I^ production. ( 23006543 )
2013
26
A case of adult periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome associated with endocapillary proliferative glomerulonephritis. ( 20225048 )
2013
27
Severe post-streptococcal acute glomerulonephritis and periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 23679171 )
2013
28
Lymph-node-first presentation of Kawasaki disease compared with bacterial cervical adenitis and typical Kawasaki disease. ( 23305955 )
2013
29
Incidence, clinical characteristics and outcome in Norwegian children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; a population-based study. ( 23106338 )
2013
30
Profile of inflammatory mediators in tonsils of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 23877488 )
2013
31
Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 23983059 )
2013
32
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. ( 22931584 )
2012
33
Chronic cervical adenitis in an infant born to a woman with discoid lupus. ( 22438346 )
2012
34
An eight-month-old child with cervical adenitis. ( 23997784 )
2012
35
Periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis. ( 22759839 )
2012
36
Familial cases of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 21074183 )
2011
37
Long-term follow-up of children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 21798555 )
2011
38
Randomized trial of adenotonsillectomy versus expectant treatment in PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome: is the impasse over? ( 20138308 )
2010
39
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). ( 20824883 )
2010
40
Extracts from The Cochrane Library: Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). ( 20869553 )
2010
41
Surgical outcomes and histology findings after tonsillectomy in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 20015793 )
2010
42
Tubercular cervical adenitis: clinicopathologic analysis of 180 cases. ( 19769820 )
2009
43
Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults. ( 18605359 )
2008
44
Commentary: The natural history of nontuberculous mycobacterial cervical adenitis. ( 18787499 )
2008
45
C-reactive protein in the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. ( 17937691 )
2007
46
First Canadian Reports of Cervical Adenitis Due to Mycobacterium Malmoense and a 10-year Review of Nontuberculous Mycobacterial Adenitis. ( 18418488 )
2006
47
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. ( 15302155 )
2004
48
Nontuberculous mycobacterial cervical adenitis: a ten-year retrospective review. ( 12514400 )
2003
49
Three cases of atypical mycobacterial cervical adenitis. ( 12612115 )
2003
50
Utility of tonsillectomy in 2 patients with the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. ( 12810475 )
2003

Variations for Cervical Adenitis

Expression for Cervical Adenitis

Search GEO for disease gene expression data for Cervical Adenitis.

Pathways for Cervical Adenitis

GO Terms for Cervical Adenitis

Cellular components related to Cervical Adenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 autophagosome GO:0005776 8.96 IL1B MEFV
2 NLRP3 inflammasome complex GO:0072559 8.62 CARD8 NLRP3

Biological processes related to Cervical Adenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.63 FCGR1A MEFV NLRP3
2 inflammatory response GO:0006954 9.54 IL1B MEFV NLRP3
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.43 CARD8 NLRP3
4 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.4 CARD8 NLRP3
5 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.32 CARD8 NLRP3
6 positive regulation of interleukin-1 beta secretion GO:0050718 9.26 CARD8 NLRP3
7 negative regulation of interleukin-1 beta secretion GO:0050713 9.16 CARD8 NLRP3
8 negative regulation of inflammatory response GO:0050728 9.13 MEFV MVK NLRP3
9 interleukin-1 beta production GO:0032611 8.62 IL1B NLRP3

Sources for Cervical Adenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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