MCID: CRV030
MIFTS: 30

Cervical Adenitis malady

Category: Immune diseases

Aliases & Classifications for Cervical Adenitis

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Aliases & Descriptions for Cervical Adenitis:

Name: Cervical Adenitis 11 13
 
Cervical Lymphadenitis 11 68

Classifications:



External Ids:

Disease Ontology11 DOID:4637
SNOMED-CT62 3502005
NCIt45 C26937

Summaries for Cervical Adenitis

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MalaCards based summary: Cervical Adenitis, also known as cervical lymphadenitis, is related to periodic fever, aphthous stomatitis, pharyngitis and adenitis and cervicitis. An important gene associated with Cervical Adenitis is IL1B (Interleukin 1 Beta), and among its related pathways are Pertussis and IL1 and megakaryocytes in obesity. Affiliated tissues include neutrophil, monocytes and tonsil.

Related Diseases for Cervical Adenitis

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Diseases related to Cervical Adenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1periodic fever, aphthous stomatitis, pharyngitis and adenitis11.2
2cervicitis10.7
3pharyngitis10.4
4stomatitis10.4
5aphthous stomatitis10.4
6tau syndrome10.2IL1B, MEFV
7bile reflux10.2FCGR1A, MEFV
8amelanotic melanoma10.2IL1B, NLRP3
9perineocele10.2FCGR1A, MEFV
10egg allergy10.2IL1B, NLRP3
11warthin tumor10.2IL1B, NLRP3
12cataract10.2CRP, IL1B
13laryngotracheoesophageal cleft type 210.2CRP, IL1B
14human immunodeficiency virus infectious disease10.2CRP, IL1B
15cerebrum cancer10.2CRP, IL1B
16familial hyperthyroidism due to mutations in tsh receptor10.2IL1B, NLRP3
17megaloblastic anemia10.2CRP, IL1B
18senile reticular retinal degeneration10.2IL1B, NLRP3
19pulmonary artery coming from the aorta10.2MEFV, NLRP3
20neuropathy10.2CRP, IL1B
21invasive aspergillosis10.1MEFV, NLRP3
22urticaria10.1CRP, IL1B
23atrophy of prostate10.1CRP, IL1B
24anaplastic ganglioglioma10.1CRP, MEFV
25cyclotropia10.1CRP, MEFV
26cutaneous sclerosis10.1CRP, NLRP3
27dermatomycosis10.1CRP, MEFV
28blepharochalasis10.1CRP, IL1B
29natural killer cell leukemia10.1CRP, NLRP3
30esotropia10.1CRP, MEFV
31chordoid meningioma10.1CRP, IL1B
32generalized dystonia10.1CRP, MEFV
33choroiditis10.1CRP, IL1B
34candidiasis, familial, 4, autosomal recessive10.1MEFV, MVK
35skin conditions10.1IL1B, NLRP3
36strawberry gallbladder10.1CRP, MEFV
37rift valley fever10.1CRP, IL1B
38infancy electroclinical syndrome10.1CRP, IL1B
39myiasis10.1CRP, MEFV
40baritosis10.1IL1B, NLRP3
41immunodeficiency 910.1CRP, MVK
42granulomatous hepatitis10.1CRP, IL1B
43female breast upper-inner quadrant cancer10.1CRP, NLRP3
44multinodular goiter10.1CRP, NLRP3
45unilateral hypoactive labyrinth10.1CRP, IL1B
46pyelonephritis10.1CRP, IL1B
47colon adenocarcinoma10.0CRP, IL1B
48muckle-wells syndrome10.0IL1B, MEFV, NLRP3
49benign neonatal seizures10.0CRP, IL1B, MEFV
50gonococcal endophthalmia10.0IL1B, MEFV, NLRP3

Graphical network of the top 20 diseases related to Cervical Adenitis:



Diseases related to cervical adenitis

Symptoms & Phenotypes for Cervical Adenitis

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Drugs & Therapeutics for Cervical Adenitis

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Drugs for Cervical Adenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AcidophilusNutraceuticalPhase 2558
2BifidobacteriumNutraceuticalPhase 2247
3ImmunoglobulinsPhase 16394
4AntibodiesPhase 16394
5Antibodies, MonoclonalPhase 14039

Interventional clinical trials:

idNameStatusNCT IDPhase
1Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled StudyWithdrawnNCT01614977Phase 3
2Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA)Not yet recruitingNCT02535962Phase 2
3Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA)Not yet recruitingNCT02775994Phase 1
4Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical LymphadenopathyUnknown statusNCT01310933
5Clinical Studies of Kikuchi's DiseaseWithdrawnNCT00172445

Search NIH Clinical Center for Cervical Adenitis

Genetic Tests for Cervical Adenitis

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Anatomical Context for Cervical Adenitis

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MalaCards organs/tissues related to Cervical Adenitis:

36
Neutrophil, Monocytes, Tonsil, Lymph node

Publications for Cervical Adenitis

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Articles related to Cervical Adenitis:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) syndrome: analysis of patients from two geographic areas. (27059542)
2016
2
Is colchicine an effective treatment in periodic fever, aphtous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome? (27068612)
2016
3
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome: a Review of the Pathogenesis. (26984802)
2016
4
Review of autoinflammatory diseases, with a special focus on periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. (27426283)
2016
5
Tuberculosis Cervical Adenitis: Management Dilemmas. (27273690)
2016
6
Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome. (26315860)
2015
7
The Pathogenesis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: A Review of Current Research. (26457006)
2015
8
Analysis of the genetic basis of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. (25988833)
2015
9
Reduced number of CD8+ cells in tonsillar germinal centers in children with the Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. (25882211)
2015
10
International periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome cohort: description of distinct phenotypes in 301 patients. (24505122)
2014
11
Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Syndrome in Iranian Children First Report of Iranian Periodic Fever and Autoinflammatory Registry (IPFAIR). (25793068)
2014
12
Markedly elevated CD64 expressions on neutrophils and monocytes are useful for diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome during flares. (24623459)
2014
13
Vitamin D levels and effects of vitamin D replacement in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. (24746456)
2014
14
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (25209127)
2014
15
Incidence, clinical characteristics and outcome in Norwegian children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; a population-based study. (23106338)
2013
16
Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1I^ production. (23006543)
2013
17
Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. (23983059)
2013
18
A case of adult periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome associated with endocapillary proliferative glomerulonephritis. (20225048)
2013
19
Lymph-node-first presentation of Kawasaki disease compared with bacterial cervical adenitis and typical Kawasaki disease. (23305955)
2013
20
Profile of inflammatory mediators in tonsils of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. (23877488)
2013
21
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system. (24134207)
2013
22
Severe post-streptococcal acute glomerulonephritis and periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. (23679171)
2013
23
Chronic cervical adenitis in an infant born to a woman with discoid lupus. (22438346)
2012
24
An eight-month-old child with cervical adenitis. (23997784)
2012
25
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. (22931584)
2012
26
Periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis. (22759839)
2012
27
Familial cases of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. (21074183)
2011
28
Long-term follow-up of children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. (21798555)
2011
29
Surgical outcomes and histology findings after tonsillectomy in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. (20015793)
2010
30
Randomized trial of adenotonsillectomy versus expectant treatment in PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome: is the impasse over? (20138308)
2010
31
Extracts from The Cochrane Library: Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20869553)
2010
32
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20824883)
2010
33
Tubercular cervical adenitis: clinicopathologic analysis of 180 cases. (19769820)
2009
34
Commentary: The natural history of nontuberculous mycobacterial cervical adenitis. (18787499)
2008
35
Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults. (18605359)
2008
36
C-reactive protein in the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. (17937691)
2007
37
First Canadian Reports of Cervical Adenitis Due to Mycobacterium Malmoense and a 10-year Review of Nontuberculous Mycobacterial Adenitis. (18418488)
2006
38
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. (15302155)
2004
39
Three cases of atypical mycobacterial cervical adenitis. (12612115)
2003
40
Utility of tonsillectomy in 2 patients with the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. (12810475)
2003
41
Nontuberculous mycobacterial cervical adenitis: a ten-year retrospective review. (12514400)
2003
42
Isolation of Mycobacterium bovis from human cases of cervical adenitis in Tanzania: a cause for concern? (11263522)
2001
43
Management of nontuberculous mycobacterial cervical adenitis. (10917237)
2000
44
Mycobacterial cervical adenitis in Auckland: diagnosis by fine needle aspirate. (10073157)
1999
45
Cervical adenitis due to Mycobacterium fortuitum in patients with acquired immunodeficiency syndrome. (9427575)
1998
46
Diagnostic problems of tuberculous cervical adenitis (scrofula). (9164624)
1997
47
Nontuberculous mycobacterial cervical adenitis. (9241478)
1997
48
Cervical adenitis and deep neck infection caused by Streptococcus pneumoniae. (9271051)
1997
49
Application of a PCR based DNA probe for the rapid identification of Mycobacterium malmoense isolated from a case of cervical adenitis. (8945716)
1996
50
The application of ultrasound criteria for malignancy in differentiating tuberculous cervical adenitis from metastatic nasopharyngeal carcinoma. (7789023)
1995

Variations for Cervical Adenitis

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Expression for genes affiliated with Cervical Adenitis

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Search GEO for disease gene expression data for Cervical Adenitis.

Pathways for genes affiliated with Cervical Adenitis

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Pathways related to Cervical Adenitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6IL1B, NLRP3
29.6IL1B, NLRP3
39.1IL1B, MEFV, NLRP3

GO Terms for genes affiliated with Cervical Adenitis

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Biological processes related to Cervical Adenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:003261110.1IL1B, NLRP3
2inflammatory responseGO:00069549.1CRP, IL1B, MEFV, NLRP3
3negative regulation of inflammatory responseGO:00507288.9MEFV, MVK, NLRP3

Sources for Cervical Adenitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet