MCID: CRV030
MIFTS: 30

Cervical Adenitis malady

Categories: Immune diseases

Aliases & Classifications for Cervical Adenitis

Aliases & Descriptions for Cervical Adenitis:

Name: Cervical Adenitis 12 14
Cervical Lymphadenitis 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4637
NCIt 47 C26937
SNOMED-CT 64 3502005
UMLS 69 C0149642

Summaries for Cervical Adenitis

MalaCards based summary : Cervical Adenitis, also known as cervical lymphadenitis, is related to periodic fever, aphthous stomatitis, pharyngitis and adenitis and cervicitis. An important gene associated with Cervical Adenitis is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Pertussis and Nucleotide-binding Oligomerization Domain (NOD) pathway. The drugs Acidophilus and Bifidobacterium have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, monocytes and lymph node.

Related Diseases for Cervical Adenitis

Diseases related to Cervical Adenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
id Related Disease Score Top Affiliating Genes
1 periodic fever, aphthous stomatitis, pharyngitis and adenitis 11.2
2 cervicitis 10.7
3 pharyngitis 10.4
4 stomatitis 10.4
5 aphthous stomatitis 10.4
6 tau syndrome 10.2 IL1B MEFV
7 bile reflux 10.2 FCGR1A MEFV
8 amelanotic melanoma 10.2 IL1B NLRP3
9 perineocele 10.2 FCGR1A MEFV
10 egg allergy 10.2 IL1B NLRP3
11 warthin tumor 10.2 IL1B NLRP3
12 cataract 10.2 CRP IL1B
13 laryngotracheoesophageal cleft type 2 10.2 CRP IL1B
14 human immunodeficiency virus infectious disease 10.2 CRP IL1B
15 cerebrum cancer 10.2 CRP IL1B
16 familial hyperthyroidism due to mutations in tsh receptor 10.2 IL1B NLRP3
17 megaloblastic anemia 10.2 CRP IL1B
18 senile reticular retinal degeneration 10.2 IL1B NLRP3
19 pulmonary artery coming from the aorta 10.2 MEFV NLRP3
20 neuropathy 10.2 CRP IL1B
21 invasive aspergillosis 10.1 MEFV NLRP3
22 urticaria 10.1 CRP IL1B
23 atrophy of prostate 10.1 CRP IL1B
24 anaplastic ganglioglioma 10.1 CRP MEFV
25 cyclotropia 10.1 CRP MEFV
26 cutaneous sclerosis 10.1 CRP NLRP3
27 dermatomycosis 10.1 CRP MEFV
28 blepharochalasis 10.1 CRP IL1B
29 natural killer cell leukemia 10.1 CRP NLRP3
30 esotropia 10.1 CRP MEFV
31 chordoid meningioma 10.1 CRP IL1B
32 generalized dystonia 10.1 CRP MEFV
33 choroiditis 10.1 CRP IL1B
34 candidiasis, familial, 4, autosomal recessive 10.1 MEFV MVK
35 skin conditions 10.1 IL1B NLRP3
36 strawberry gallbladder 10.1 CRP MEFV
37 rift valley fever 10.1 CRP IL1B
38 infancy electroclinical syndrome 10.1 CRP IL1B
39 myiasis 10.1 CRP MEFV
40 baritosis 10.1 IL1B NLRP3
41 immunodeficiency 9 10.1 CRP MVK
42 granulomatous hepatitis 10.1 CRP IL1B
43 female breast upper-inner quadrant cancer 10.1 CRP NLRP3
44 multinodular goiter 10.1 CRP NLRP3
45 unilateral hypoactive labyrinth 10.1 CRP IL1B
46 pyelonephritis 10.1 CRP IL1B
47 colon adenocarcinoma 10.0 CRP IL1B
48 muckle-wells syndrome 10.0 IL1B MEFV NLRP3
49 benign neonatal seizures 10.0 CRP IL1B MEFV
50 gonococcal endophthalmia 10.0 IL1B MEFV NLRP3

Graphical network of the top 20 diseases related to Cervical Adenitis:



Diseases related to Cervical Adenitis

Symptoms & Phenotypes for Cervical Adenitis

Drugs & Therapeutics for Cervical Adenitis

Drugs for Cervical Adenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Acidophilus Nutraceutical Phase 2
2 Bifidobacterium Nutraceutical Phase 2
3 Immunoglobulins Phase 1
4 Antibodies, Monoclonal Phase 1
5 Antibodies Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3
2 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Not yet recruiting NCT02535962 Phase 2
3 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Not yet recruiting NCT02775994 Phase 1
4 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
5 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Cervical Adenitis

Genetic Tests for Cervical Adenitis

Anatomical Context for Cervical Adenitis

MalaCards organs/tissues related to Cervical Adenitis:

39
Neutrophil, Monocytes, Lymph Node, Tonsil

Publications for Cervical Adenitis

Articles related to Cervical Adenitis:

(show top 50) (show all 115)
id Title Authors Year
1
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) syndrome: analysis of patients from two geographic areas. ( 27059542 )
2016
2
Is colchicine an effective treatment in periodic fever, aphtous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome? ( 27068612 )
2016
3
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome: a Review of the Pathogenesis. ( 26984802 )
2016
4
Review of autoinflammatory diseases, with a special focus on periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. ( 27426283 )
2016
5
Tuberculosis Cervical Adenitis: Management Dilemmas. ( 27273690 )
2016
6
Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome. ( 26315860 )
2015
7
The Pathogenesis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: A Review of Current Research. ( 26457006 )
2015
8
Analysis of the genetic basis of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 25988833 )
2015
9
Reduced number of CD8+ cells in tonsillar germinal centers in children with the Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. ( 25882211 )
2015
10
International periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome cohort: description of distinct phenotypes in 301 patients. ( 24505122 )
2014
11
Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Syndrome in Iranian Children First Report of Iranian Periodic Fever and Autoinflammatory Registry (IPFAIR). ( 25793068 )
2014
12
Markedly elevated CD64 expressions on neutrophils and monocytes are useful for diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome during flares. ( 24623459 )
2014
13
Vitamin D levels and effects of vitamin D replacement in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 24746456 )
2014
14
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). ( 25209127 )
2014
15
Incidence, clinical characteristics and outcome in Norwegian children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; a population-based study. ( 23106338 )
2013
16
Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1I^ production. ( 23006543 )
2013
17
Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 23983059 )
2013
18
A case of adult periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome associated with endocapillary proliferative glomerulonephritis. ( 20225048 )
2013
19
Lymph-node-first presentation of Kawasaki disease compared with bacterial cervical adenitis and typical Kawasaki disease. ( 23305955 )
2013
20
Profile of inflammatory mediators in tonsils of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 23877488 )
2013
21
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system. ( 24134207 )
2013
22
Severe post-streptococcal acute glomerulonephritis and periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 23679171 )
2013
23
Chronic cervical adenitis in an infant born to a woman with discoid lupus. ( 22438346 )
2012
24
An eight-month-old child with cervical adenitis. ( 23997784 )
2012
25
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. ( 22931584 )
2012
26
Periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis. ( 22759839 )
2012
27
Familial cases of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 21074183 )
2011
28
Long-term follow-up of children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 21798555 )
2011
29
Surgical outcomes and histology findings after tonsillectomy in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. ( 20015793 )
2010
30
Randomized trial of adenotonsillectomy versus expectant treatment in PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome: is the impasse over? ( 20138308 )
2010
31
Extracts from The Cochrane Library: Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). ( 20869553 )
2010
32
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). ( 20824883 )
2010
33
Tubercular cervical adenitis: clinicopathologic analysis of 180 cases. ( 19769820 )
2009
34
Commentary: The natural history of nontuberculous mycobacterial cervical adenitis. ( 18787499 )
2008
35
Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults. ( 18605359 )
2008
36
C-reactive protein in the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. ( 17937691 )
2007
37
First Canadian Reports of Cervical Adenitis Due to Mycobacterium Malmoense and a 10-year Review of Nontuberculous Mycobacterial Adenitis. ( 18418488 )
2006
38
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. ( 15302155 )
2004
39
Three cases of atypical mycobacterial cervical adenitis. ( 12612115 )
2003
40
Utility of tonsillectomy in 2 patients with the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. ( 12810475 )
2003
41
Nontuberculous mycobacterial cervical adenitis: a ten-year retrospective review. ( 12514400 )
2003
42
Isolation of Mycobacterium bovis from human cases of cervical adenitis in Tanzania: a cause for concern? ( 11263522 )
2001
43
Management of nontuberculous mycobacterial cervical adenitis. ( 10917237 )
2000
44
Mycobacterial cervical adenitis in Auckland: diagnosis by fine needle aspirate. ( 10073157 )
1999
45
Cervical adenitis due to Mycobacterium fortuitum in patients with acquired immunodeficiency syndrome. ( 9427575 )
1998
46
Diagnostic problems of tuberculous cervical adenitis (scrofula). ( 9164624 )
1997
47
Nontuberculous mycobacterial cervical adenitis. ( 9241478 )
1997
48
Cervical adenitis and deep neck infection caused by Streptococcus pneumoniae. ( 9271051 )
1997
49
Application of a PCR based DNA probe for the rapid identification of Mycobacterium malmoense isolated from a case of cervical adenitis. ( 8945716 )
1996
50
The application of ultrasound criteria for malignancy in differentiating tuberculous cervical adenitis from metastatic nasopharyngeal carcinoma. ( 7789023 )
1995

Variations for Cervical Adenitis

Expression for Cervical Adenitis

Search GEO for disease gene expression data for Cervical Adenitis.

Pathways for Cervical Adenitis

Pathways related to Cervical Adenitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.04 IL1B NLRP3
2 10.41 IL1B MEFV NLRP3
3 10.35 IL1B NLRP3

GO Terms for Cervical Adenitis

Biological processes related to Cervical Adenitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.46 CRP IL1B MEFV NLRP3
2 negative regulation of inflammatory response GO:0050728 9.13 MEFV MVK NLRP3
3 interleukin-1 beta production GO:0032611 8.62 IL1B NLRP3

Sources for Cervical Adenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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