MCID: CRV031
MIFTS: 46

Cervical Adenocarcinoma malady

Reproductive, Cancer categories

Summaries for Cervical Adenocarcinoma

Sources:
33MalaCards
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MalaCards: Cervical Adenocarcinoma, also known as adenocarcinoma of the uterine cervix, is related to adenocarcinoma and adenocarcinoma in situ. An important gene associated with Cervical Adenocarcinoma is CDH3 (cadherin 3, type 1, P-cadherin (placental)), and among its related pathways are Glioma and p53 signaling pathway. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Cervical Adenocarcinoma

Sources:
8Disease Ontology, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Reproductive


Aliases & Descriptions:

cervical adenocarcinoma 8 45 49 61
adenocarcinoma of the uterine cervix 8
adenocarcinoma of the cervix uteri 49
adenocarcinoma cervix uteri 8
adenocarcinoma of cervix 8


External Ids:

Disease Ontology8 DOID:3702
NCIt40 C4029
ICD10 via Orphanet26 C53

Related Diseases for Cervical Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cervical Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
2adenocarcinoma in situ30.7CDKN2A
3squamous cell carcinoma30.6CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
4adenosquamous carcinoma30.4CEACAM5, CEACAM7, KRT8, KRT20, KRT7, NME1
5wilms tumor30.4KRT7, RASSF1, CALB2
6signet ring cell adenocarcinoma30.4CEACAM5, KRT20, KRT7
7cervical intraepithelial neoplasia29.9KRT8, NME1, CDKN2A, IFI27
8clear cell adenocarcinoma29.9MUC16, IFI27
9adenoma29.9CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
10papillary serous adenocarcinoma10.6
11cervix squamous papilloma10.4
12hemihypertrophy10.4
13early invasive cervical adenocarcinoma10.4
14cervix endometriosis10.3
15bilateral breast cancer10.3
16glassy cell carcinoma of the cervix10.3
17peutz-jeghers syndrome10.1
18breast adenocarcinoma10.1
19peutz–jeghers syndrome10.1
20esophagitis10.0CDX2
21cystadenoma10.0KRT7
22teratoma10.0KRT7
23ductal carcinoma in situ10.0PGR
24stomach cancer10.0CDX2
25leiomyoma10.0PGR
26peritonitis10.0MUC16
27rhabdomyosarcoma10.0CALB2
28secretory meningioma10.0KRT7
29gastrointestinal stromal tumor10.0IFI27
30pituitary adenoma10.0CDKN1B, CDH3, IFI27
31meningioma10.0PGR, CALB2
32liver cirrhosis10.0KRT8
33chordoma10.0KRT8, KRT7
34neuroblastoma10.0NME1
35hepatoblastoma10.0KRT7
36laryngeal carcinoma10.0NME1, IFI27
37gastritis10.0CDX2, MUC5AC
38pituitary tumors10.0CDKN1B, IFI27
39hepatitis b10.0KRT8
40hepatitis10.0KRT8, CXCL12
41sarcoma10.0LAMC2, KRT8, CALB2
42hepatitis c10.0CXCL12
43cystadenocarcinoma10.0CEACAM5, MUC5AC, MUC16
44pseudomyxoma peritonei10.0KRT20, KRT7, CDX2, MUC5AC
45leydig cell tumor10.0CALB2
46bladder adenocarcinoma10.0KRT20, KRT7, CDX2
47thymic carcinoma10.0KRT7, CALB2
48smooth muscle tumor10.0NME1, PGR, IFI27
49adenomatoid tumor10.0CALB2
50angiomyolipoma10.0PGR

Graphical network of the top 20 diseases related to Cervical Adenocarcinoma:



Diseases related to cervical adenocarcinoma

Clinical Features for Cervical Adenocarcinoma

Drugs & Therapeutics for Cervical Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cervical Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Cervical Adenocarcinoma

Search NIH Clinical Center for Cervical Adenocarcinoma

Search CenterWatch for Cervical Adenocarcinoma

Genetic Tests for Cervical Adenocarcinoma

Anatomical Context for Cervical Adenocarcinoma

Animal Models for Cervical Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cervical Adenocarcinoma

Sources:
51PubMed
See all sources

Articles related to Cervical Adenocarcinoma:

(show top 50)    (show all 324)
idTitleAuthorsYear
1
Prognosis of Adenosquamous Carcinoma Compared With Adenocarcinoma in Uterine Cervical Cancer: A Systematic Review and Meta-Analysis of Observational Studies. (24407572)
2014
2
ERCC1 Expression and Chemosensitivity in Uterine Cervical Adenocarcinoma Cells. (24403450)
2014
3
Human papillomavirus detected in a colonic metastasis of cervical adenocarcinoma. (23549714)
2013
4
Cutaneous metastasis of cervical adenocarcinoma to the vulva. (24011272)
2013
5
Analysis of prognosis-related factors in patients with invasive cervical adenocarcinoma. (22053661)
2011
6
Cervical adenocarcinoma with clear cell morphology. report of six cases and literature review. (21446339)
2011
7
Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme. (20423964)
2010
8
Composite cervical adenocarcinoma composed of adenoma malignum and gastric type adenocarcinoma (dedifferentiated adenoma malignum) in a patient with Peutz Jeghers syndrome. (20876329)
2010
9
(18)F-FDG PET in stage IB/IIB cervical adenocarcinoma/adenosquamous carcinoma. (20069296)
2010
10
The relationship between human papillomavirus and Epstein-Barr virus infections in relation to age of patients with cervical adenocarcinoma. (20045757)
2009
11
Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. (19095810)
2009
12
Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ. (18234283)
2008
13
On the mechanism of phenotypic conversion of human cervical adenocarcinoma HeLa cells surviving infection by influenza B virus: potential implications for biological management of adenocarcinomas. (18291599)
2008
14
Lobular endocervical glandular hyperplasia as a presumed precursor of cervical adenocarcinoma independent of human papillomavirus infection. (17540439)
2007
15
Effect of prophylactic human papillomavirus L1 virus-like-particle vaccine on risk of cervical intraepithelial neoplasia grade 2, grade 3, and adenocarcinoma in situ: a combined analysis of four randomised clinical trials. (17544766)
2007
16
Adenosquamous carcinoma versus adenocarcinoma in early-stage cervical cancer patients undergoing radical hysterectomy: an outcomes analysis. (17854872)
2007
17
Variants of human papillomavirus types 16 and 18: histological findings in women referred for atypical glandular cells or adenocarcinoma in situ in cervical smear. (16990718)
2006
18
The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma. (16426920)
2006
19
Pathological characteristics of cervical adenocarcinoma in a multi-center US-based study. (16697450)
2006
20
Increased cyclooxygenase-2 expression is correlated with suppressed antitumor immunity in cervical adenocarcinomas. (16681759)
2006
21
Evaluation of PTEN expression in cervical adenocarcinoma by tissue microarray. (16803514)
2006
22
Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma. (16331610)
2006
23
Pelvic sidewall adenocarcinoma after definitive therapy for cervical adenocarcinoma in situ. (16054200)
2005
24
Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells. (15942648)
2005
25
Management of cervical adenocarcinoma in situ during pregnancy. (15902134)
2005
26
Is improved detection of adenocarcinoma in situ by screening a key to reducing the incidence of cervical adenocarcinoma? (15471248)
2004
27
Increasing trends of cervical adenocarcinoma incidence in Central Italy despite Extensive Screening Programme, 1985-2000. (15582270)
2004
28
Adenosquamous histology predicts poor outcome in low-risk stage IB1 cervical adenocarcinoma. (14675676)
2003
29
Cervical adenocarcinoma survival among Hispanic and white women: a multicenter cohort study. (12634634)
2003
30
Treatment of recurrent cervical adenocarcinoma with BMS-247550, an epothilone B analog. (12821348)
2003
31
Correlation of p16INK4A overexpression with human papillomavirus infection in cervical adenocarcinomas. (14501820)
2003
32
Pregnancy following radical trachelectomy and pelvic lymphadenectomy for Stage I cervical adenocarcinoma. (12174169)
2002
33
Atypical polypoid adenomyoma mimicking cervical adenocarcinoma. (17050990)
2002
34
Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups: a population based study with review of all nonsquamous cervical carcinomas in Norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990. (11002225)
2000
35
Recurrent invasive adenocarcinoma after hysterectomy for cervical adenocarcinoma in situ. (10785491)
2000
36
Clinical pathological analysis and immunohistochemical expression of primary cervical adenocarcinoma in 98 cases]. (11869532)
1999
37
Stage IA1 cervical adenocarcinoma: definition and treatment. (9932559)
1999
38
Effects of EGF and TGF-alpha on invasion and proteinase expression of uterine cervical adenocarcinoma OMC-4 cells. (10640903)
1998-1999
39
A case of concurrent uterine cervical adenocarcinoma and renal-cell carcinoma, and subsequent vaginal metastasis from the renal-cell carcinoma. (9564104)
1998
40
CA 125 is dominantly expressed by arrest of G0/G1 phase in uterine cervical adenocarcinoma cell line. (9887247)
1998
41
The human papillomavirus status of invasive cervical adenocarcinoma: a clinicopathological and outcome analysis. (7890285)
1995
42
Cervical adenocarcinomas express markers common to gastric, intestinal, and pancreatobiliary epithelial cells. (8078803)
1994
43
A clinicopathological study of adenocarcinoma in situ of the cervix. The influence of cervical HPV infection and other factors, and the role of conservative surgery. (1656927)
1991
44
Demonstration of low frequency of human papillomavirus DNA in cervical adenocarcinoma and adenocarcinoma in situ by the polymerase chain reaction and in situ hybridization. (1848834)
1991
45
Analysis of point mutations at codon 12 of K-ras in human endometrial carcinoma and cervical adenocarcinoma by dot blot hybridization and polymerase chain reaction. (1812593)
1991
46
Human papillomavirus DNA in adenocarcinoma in situ, microinvasive adenocarcinoma of the uterine cervix, and coexisting cervical squamous intraepithelial neoplasia. (2540102)
1989
47
New monoclonal antibody, 1C5, reactive with human cervical adenocarcinoma of the uterus, with immunodiagnostic potential. (3052807)
1988
48
Cervical adenocarcinoma: tumor implantation in the episiotomy sites of two patients. (3666581)
1987
49
Peutz-Jeghers syndrome with cervical adenocarcinoma and enteritis cystica profunda. (6495730)
1984
50
Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma. (6890656)
1982

Genetic Variations for Cervical Adenocarcinoma

Expression for genes affiliated with Cervical Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cervical Adenocarcinoma

Search GEO for disease gene expression data for Cervical Adenocarcinoma.

Pathways for genes affiliated with Cervical Adenocarcinoma

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CDKN1A
2
Hide members
10.4CDKN1B, CDKN2A, CDKN1A
310.4CDKN2A, CDKN1A, CDKN1B
4
Hide members
10.4CDKN1B, CDKN1A, CDKN2A
510.4CDKN2A, CDKN1A, CDKN1B
6
Hide members
10.4CDKN1B, CDKN1A, CDKN2A
710.4CDKN2A, CDKN1A, CDKN1B, RASSF1
8
Cell cycle Cell cycle (generic schema)
Hide members
10.4CDKN1A, PGR, CDKN1B, CDKN2A
9
Hide members
10.4CDKN1A, CDKN1B, PGR, CXCL12
1010.3LAMC2, CDKN2A, CDKN1A, CDKN1B, RASSF1
11
Hide members
10.3LAMC2, CXCL12, CDKN1B, CDKN2A, CDKN1A, CDH3

Compounds for genes affiliated with Cervical Adenocarcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8CEACAM7, CALB2
2butyrate4510.8CDX2, CEACAM7, CALB2
3crcs4510.7CEACAM5, NME1, CDKN2A, RASSF1
4cycloheximide4510.7CXCL12, KRT8, CEACAM7
5mucicarmine4510.7CEACAM7, KRT7, KRT20, CEACAM5, CALB2
6gefitinib45 50 1112.7IFI27, CEACAM5, CDKN1B, CDKN1A, CEACAM7
7gold4510.7MUC16, KRT8, LAMC2, CEACAM5
8estradiol45 11 2412.7MUC16, PGR, CEACAM5
9adriamycin4510.7CEACAM5, CDKN2A, CDKN1A, PGR, KRT8
105-aza-2deoxycytidine4510.7CXCL12, RASSF1, CDKN2A, CDX2, CDKN1A, KRT7
11agar4510.7CEACAM5, KRT8, RASSF1, NME1, PGR, CDKN1A
12b 7234510.6CALB2, MUC16, KRT8, CEACAM5, CEACAM7, KRT20
13genistein45 29 60 2 11 2415.6IFI27, CDKN1B, KRT8, CXCL12, PGR, CDKN1A
14tamoxifen45 50 29 1113.6CXCL12, IFI27, CDKN1A, CDKN1B, PGR, KRT8
15retinoid4510.6CDKN1A, MUC5AC, IFI27, KRT8, PGR, KRT7
16resveratrol45 60 11 2413.6PGR
17ribonucleic acid4510.6CXCL12, PGR, MUC5AC, CEACAM5, KRT20, NME1
185fluorouracil4510.6CDKN2A, MUC5AC, PGR, CXCL12, NME1, CEACAM7
19actinomycin d4510.6CEACAM7, KRT8, CXCL12, CDKN1B, CDKN2A, CDKN1A
20dexamethasone45 50 29 1113.6MUC16, MUC5AC, CDKN2A, CXCL12, CDKN1B, IFI27
21n-acetylglucosamine4510.6KRT7, KRT8, MUC5AC, CEACAM5
22hyaluronic acid45 2411.6CEACAM5, KRT20, CALB2, CXCL12, MUC16
23hematoxylin4510.6KRT8, MUC16, CEACAM5, KRT20, MUC5AC, CDKN2A
24methotrexate45 50 1112.6CDKN1B, MUC5AC, CDKN2A, PGR, KRT7
25paclitaxel45 50 1112.6CALB2, IFI27, MUC16, CDKN2A, CDKN1A, CDKN1B
26steroid4510.6IFI27, MUC5AC, CDKN2A, CDX2, CXCL12, NME1
27oligonucleotide4510.6MUC5AC, IFI27, CDKN2A, CDX2, CDKN1A, CDKN1B
28lovastatin45 50 60 29 1114.6CDKN1B, CDKN1A, IFI27, CDKN2A
29thymidine45 2411.6CEACAM5, CALB2, IFI27, CDX2, CDKN1A, CXCL12
30cisplatin45 50 60 1113.6KRT8, RASSF1, NME1, CDKN1B, CDKN1A, CDKN2A
31doxorubicin45 50 1112.6CDKN2A, KRT8, KRT20, PGR, CDKN1B, CDKN1A
32n acetylcysteine4510.6CDKN1B, CDKN2A, IFI27, MUC5AC, CDKN1A
33p0034510.6CEACAM5, IFI27, RASSF1, CDKN1B
34threonine4510.6RASSF1, CXCL12, CDKN1B, CDKN1A, CDKN2A, MUC5AC
35cytarabine45 50 1112.6CDKN1B, CDKN1A, CDKN2A, IFI27
36eb 108945 6011.5CDKN1A, IFI27, CDKN1B
37retinoic acid45 2411.5NME1, KRT7, PGR, CEACAM7, CDKN1B, CDKN1A
38testosterone45 60 11 2413.5KRT20, KRT7, CDKN2A, PGR, CDKN1B, KRT8
39vegf4510.5MUC16, IFI27, CXCL12, CDKN2A, CDKN1A, CDKN1B
40calcium45 50 11 2413.5IFI27, MUC5AC, CALB2, CDH3, CDX2, NME1
41serine4510.5RASSF1, CDKN1A, CDKN1B, CDKN2A, CXCL12, KRT8
42sialic acid4510.5CEACAM5, KRT7
43troglitazone45 29 60 1113.5KRT20, CDKN1B, CDKN1A, IFI27
44tyrosine4510.4CDX2, CDKN1B, KRT20, CDKN1A, CALB2, KRT7
45p000484510.4CDKN1A, IFI27
46paraffin4510.4CALB2, IFI27, MUC16, CDKN2A, MUC5AC, CDH3
47progesterone45 60 29 11 2414.3CEACAM5, MUC5AC, MUC16, IFI27, CALB2, NME1
48optimax4510.3CDKN1A, IFI27
49cysteine4510.2CEACAM5, KRT8, MUC5AC, PGR, CDKN2A, CDX2
50pd 98,0594510.0MUC5AC, CXCL12, CDKN1B, CDKN1A, IFI27

GO Terms for genes affiliated with Cervical Adenocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.4KRT8, KRT20, KRT7

Biological processes related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.6CDKN1B, CDKN2A, CDKN1A
2negative regulation of phosphorylationGO:04232610.5CDKN2A, CDKN1B, CDKN1A
3cell cycle arrestGO:00705010.5CDKN2A, CDKN1A, CDKN1B, RASSF1
4negative regulation of gene expressionGO:01062910.4CDKN1A, PGR, NME1
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.4IFI27, CDKN2A, CDKN1B
6cell adhesionGO:00715510.4MUC16, MUC5AC, LAMC2, CDH3, CXCL12
7Ras protein signal transductionGO:00726510.3CDKN2A, RASSF1, CDKN1A
8mitotic cell cycle arrestGO:07185010.1CDKN1B, CDKN1A

Molecular functions related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.4CDKN1B, CDKN1A, CDKN2A

Products for genes affiliated with Cervical Adenocarcinoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Cervical Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet