MCID: CRV031
MIFTS: 56

Cervical Adenocarcinoma malady

Reproductive diseases, Cancer diseases categories

Summaries for Cervical Adenocarcinoma

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MalaCards: Cervical Adenocarcinoma, also known as adenocarcinoma of the uterine cervix, is related to adenocarcinoma and papillary adenocarcinoma. An important gene associated with Cervical Adenocarcinoma is CDH3 (cadherin 3, type 1, P-cadherin (placental)), and among its related pathways are Glioma and p53 signaling pathway. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and testes, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Cervical Adenocarcinoma

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8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

cervical adenocarcinoma 8 44 48 60
adenocarcinoma of the uterine cervix 8
adenocarcinoma of the cervix uteri 48
adenocarcinoma cervix uteri 8
adenocarcinoma of cervix 8


External Ids:

Disease Ontology8 DOID:3702
NCIt39 C4029
SNOMED-CT via Orphanet57 254887002
ICD10 via Orphanet26 C53

Related Diseases for Cervical Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Cervical Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
2papillary adenocarcinoma31.4CEACAM5, NME1, MUC16
3adenocarcinoma in situ31.1CDKN2A
4cervical squamous cell carcinoma30.6CEACAM5, KRT8, RASSF1, CDKN1B, CDKN1A, CDKN2A
5squamous cell carcinoma30.6CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
6adenosquamous carcinoma30.4CEACAM5, CEACAM7, KRT8, KRT20, KRT7, NME1
7signet ring cell adenocarcinoma30.4CEACAM5, KRT20, KRT7
8endometriosis30.4PGR, CDH3, MUC16, EBAG9, CALB2
9breast cancer30.4CEACAM5, CEACAM7, KRT8, KRT7, RASSF1, NME1
10endometrial carcinoma30.2RASSF1, PGR, CDH3, CDKN2A, MUC16, EBAG9
11cervical cancer30.2KRT8, RASSF1, NME1, CDKN1B, CDKN1A, CDKN2A
12gastric adenocarcinoma30.2CEACAM5, CEACAM7, KRT8, KRT20, KRT7, NME1
13colon adenocarcinoma30.1CEACAM5, CEACAM7, KRT20, CDKN1B, CDKN1A, MUC5AC
14peritonitis29.9MUC16
15sarcoma29.9LAMC2, KRT8, CALB2
16papilloma29.9KRT20, RASSF1, CDKN1B, CDKN1A, CDKN2A, IFI27
17lung cancer29.9CEACAM5, CEACAM7, KRT20, KRT7, NME1, CDKN1A
18clear cell adenocarcinoma29.9MUC16, IFI27
19lung adenocarcinoma29.9CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
20adenoma29.9CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
21cervicitis11.1
22papillary serous adenocarcinoma10.6
23early invasive cervical adenocarcinoma10.4
24endocervicitis10.3
25cervical adenosquamous carcinoma10.3
26cervix endometriosis10.3
27bilateral breast cancer10.3
28pulmonary embolism10.3
29glassy cell carcinoma of the cervix10.3
30endometrial adenocarcinoma10.2
31in situ carcinoma10.2
32vaginitis10.2
33mucinous adenocarcinoma10.1
34peutz-jeghers syndrome10.1
35breast adenocarcinoma10.1
36cervical mucinous adenocarcinoma10.1
37influenza10.1
38ovary adenocarcinoma10.1
39esophagitis10.0CDX2
40cystadenoma10.0KRT7
41teratoma10.0KRT7
42ductal carcinoma in situ10.0PGR
43stomach cancer10.0CDX2
44leiomyoma10.0PGR
45rhabdomyosarcoma10.0CALB2
46secretory meningioma10.0KRT7
47gastrointestinal stromal tumor10.0IFI27
48pituitary adenoma10.0CDKN1B, CDH3, IFI27
49meningioma10.0PGR, CALB2
50liver cirrhosis10.0KRT8

Graphical network of the top 20 diseases related to Cervical Adenocarcinoma:



Diseases related to cervical adenocarcinoma

Clinical Features for Cervical Adenocarcinoma

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Drugs & Therapeutics for Cervical Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Cervical Adenocarcinoma

Search NIH Clinical Center for Cervical Adenocarcinoma

Search CenterWatch for Cervical Adenocarcinoma

Genetic Tests for Cervical Adenocarcinoma

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Anatomical Context for Cervical Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Cervical Adenocarcinoma:

32
Cervix, Lymph node, Testes, Colon, Breast, Ovary, Prostate, Lung, Thyroid, Salivary gland, Uterus

Animal Models for Cervical Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cervical Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.4RASSF1, CDKN2A, NME1, PGR, CDKN1B, CDKN1A
2MP:000538110.3MUC5AC, KRT8, CDKN1B, CDKN1A, CDX2, CDKN2A
3MP:000537910.3CDKN2A, CDH3, CDX2, CDKN1A, CDKN1B, NME1
4MP:000538710.3EBAG9, MUC5AC, CDKN2A, CDKN1A, CDKN1B, PGR
5MP:001077110.2CDKN2A, CDH3, CDKN1A, CDKN1B, NME1
6MP:000539710.2PGR, EBAG9, CDKN1B, CDKN1A, CDKN2A, KRT8
7MP:000537010.0CDKN1A, CDKN1B, CXCL12, NME1, KRT8, CDKN2A

Publications for Cervical Adenocarcinoma

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50PubMed
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Articles related to Cervical Adenocarcinoma:

(show top 50)    (show all 324)
idTitleAuthorsYear
1
Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent. (23849091)
2014
2
Prevalence and type distribution of human papillomavirus in cervical adenocarcinoma in Korean women. (23485771)
2013
3
Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix. (24037752)
2013
4
Outcome analysis of cervical adenosquamous carcinoma compared with adenocarcinoma. (22497449)
2012
5
Cervical adenocarcinoma in a patient with Lynch syndrome, Muir-Torre variant. (22124091)
2012
6
Chemoradiation and adjuvant chemotherapy in advanced cervical adenocarcinoma. (22307061)
2012
7
A lactose-binding lectin from the marine sponge Cinachyrella apion (Cal) induces cell death in human cervical adenocarcinoma cells. (22690140)
2012
8
Cervical adenocarcinoma: a retrospective clinicopathologic study of 16 cases. (22990556)
2012
9
Laparoscopic adrenalectomy for isolated adrenal metastasis from cervical squamous cell carcinoma and endometrial adenocarcinoma. (21664660)
2011
10
Cervical adenocarcinoma: moving towards better prevention. (21983356)
2011
11
Metastatic carcinomas in the cervix mimicking primary cervical adenocarcinoma and adenocarcinoma in situ: report of a series of cases. (20414103)
2010
12
Prevalence and clinical relevance of cyclooxygenase-1 and -2 expression in stage IIB cervical adenocarcinoma. (19836124)
2010
13
The two faces of cervical adenocarcinoma in situ. (20567153)
2010
14
A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics. (19188825)
2009
15
Induction of matrix metalloproteinase-9 by galectin-7 through p38 MAPK signaling in HeLa human cervical epithelial adenocarcinoma cells. (19885589)
2009
16
Mutation and protein expression of PTEN gene in cervical adenocarcinoma and glandular intraepithelial neoplasia]. (19781347)
2009
17
Significant decrease of adenocarcinoma in situ not reflected in cervical adenocarcinoma incidence in the Netherlands 1989-2003. (18182979)
2008
18
Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma. (18281151)
2008
19
Distribution of human papillomavirus types in different histological subtypes of cervical adenocarcinoma. (17600937)
2007
20
2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ. (17917567)
2007
21
Concurrent malakoplakia of cervical lymph nodes and prostatic adenocarcinoma with bony metastasis: case report. (17496990)
2006
22
Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention. (16507827)
2006
23
Validation of tissue microarray technology using cervical adenocarcinoma and its precursors as a model system. (16803510)
2006
24
Relaxin does not influence the growth of human cervical adenocarcinoma (HeLa) cells in culture. (15956748)
2005
25
Invasive cervical adenocarcinoma immediately following a cone biopsy for adenocarcinoma in situ with negative margins. (15913738)
2005
26
Prevalence of human papillomavirus DNA in various histological subtypes of cervical adenocarcinoma: a population-based study. (15502807)
2005
27
Long-term surveillance is required for all women treated for cervical adenocarcinoma in situ. (15874850)
2004
28
Early invasive cervical adenocarcinoma: its potential for nodal metastasis or recurrence. (12628261)
2003
29
High cyclooxygenase-2 expression in cervical adenocarcinomas. (12648590)
2003
30
Endocervical curettage at conization to predict residual cervical adenocarcinoma in situ. (12468353)
2002
31
Stage IIB-IVB cervical adenocarcinoma: prognostic factors and survival. (11748986)
2002
32
Infrared spectral features of exfoliated cervical cells, cervical adenocarcinoma tissue, and an adenocarcinoma cell line (SiSo). (11925139)
2002
33
Cervical adenocarcinoma in situ: a systematic review of therapeutic options and predictors of persistent or recurrent disease. (11524622)
2001
34
The role of human papillomavirus in cervical adenocarcinoma carcinogenesis. (11166153)
2001
35
A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma. (10348278)
1999
36
Early cervical adenocarcinoma: selection criteria for radical surgery. (10472864)
1999
37
Apoptosis as a criterion for sensitivity of uterine cervical adenocarcinoma to cisplatin. (9683811)
1998
38
Characterization and localization of mitochondrial oligopeptidase (MOP) (EC 3.4.24.16) activity in the human cervical adenocarcinoma cell line HeLa. (9257187)
1997
39
Decrease in tumor volume and histologic response to intraarterial neoadjuvant chemotherapy in patients with cervical and endometrial adenocarcinoma. (9159335)
1997
40
Can cervical adenocarcinoma in situ be safely managed by conization alone? (8641605)
1996
41
Establishment of a new human uterine cervical adenocarcinoma cell-line, siso, and its reactivity to anticancer reagents. (21556646)
1995
42
Antitumor effects of human recombinant interferon-gamma and tumor necrosis factor on five cervical adenocarcinoma cell lines, in vivo and in vitro. (1916508)
1991
43
Human papillomavirus type 16/18 in uterine cervical adenocarcinoma in situ and adenocarcinoma. A study by in situ hybridization with biotinylated DNA probes. (2159841)
1990
44
Cervical adenocarcinoma in young women: possible relationship to microglandular hyperplasia and use of oral contraceptives. (2726119)
1989
45
Increase of cervical adenocarcinoma: a report of 520 cases of cervical carcinoma including 112 tumors with glandular elements. (2703167)
1989
46
Histogenesis of cervical adenocarcinoma with reference to human papillomavirus-18 as a carcinogen. (2553963)
1989
47
Modulation of the antigenicity of amylase in cervical glandular atypia, adenocarcinoma in situ and invasive adenocarcinoma. (2478438)
1989
48
Cervical adenocarcinoma in situ. (3285263)
1988
49
Atypical vaginal adenosis and cervical ectropion. Association with clear cell adenocarcinoma in diethylstilbestrol-exposed offspring. (6537153)
1984
50
A study on radiosensitivity and prognostic factors of cervical adenocarcinoma. (7240826)
1980

Genetic Variations for Cervical Adenocarcinoma

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Expression for genes affiliated with Cervical Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Adenocarcinoma

Search GEO for disease gene expression data for Cervical Adenocarcinoma.

Pathways for genes affiliated with Cervical Adenocarcinoma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore
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Pathways related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CDKN1A
2
Hide members
10.4CDKN1B, CDKN2A, CDKN1A
310.4CDKN2A, CDKN1A, CDKN1B
4
Hide members
10.4CDKN1B, CDKN1A, CDKN2A
510.4CDKN2A, CDKN1A, CDKN1B
6
Hide members
10.4CDKN1B, CDKN1A, CDKN2A
710.4CDKN2A, CDKN1A, CDKN1B, RASSF1
8
Cell cycle Cell cycle (generic schema)
Hide members
10.4CDKN1A, PGR, CDKN1B, CDKN2A
9
Hide members
10.4CDKN1A, CDKN1B, PGR, CXCL12
1010.3LAMC2, CDKN2A, CDKN1A, CDKN1B, RASSF1
11
Hide members
10.3LAMC2, CXCL12, CDKN1B, CDKN2A, CDKN1A, CDH3

Compounds for genes affiliated with Cervical Adenocarcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CEACAM7, CALB2
2butyrate4410.8CDX2, CEACAM7, CALB2
3crcs4410.7CEACAM5, NME1, CDKN2A, RASSF1
4cycloheximide4410.7CXCL12, KRT8, CEACAM7
5mucicarmine4410.7CEACAM7, KRT7, KRT20, CEACAM5, CALB2
6gefitinib44 49 1112.7IFI27, CEACAM5, CDKN1B, CDKN1A, CEACAM7
7gold4410.7MUC16, KRT8, LAMC2, CEACAM5
8estradiol44 11 2412.7MUC16, PGR, CEACAM5
9adriamycin4410.7CEACAM5, CDKN2A, CDKN1A, PGR, KRT8
105-aza-2deoxycytidine4410.7CXCL12, RASSF1, CDKN2A, CDX2, CDKN1A, KRT7
11agar4410.7CEACAM5, KRT8, RASSF1, NME1, PGR, CDKN1A
12b 7234410.6CALB2, MUC16, KRT8, CEACAM5, CEACAM7, KRT20
13genistein44 28 59 2 11 2415.6IFI27, CDKN1B, KRT8, CXCL12, PGR, CDKN1A
14tamoxifen44 49 28 1113.6CXCL12, IFI27, CDKN1A, CDKN1B, PGR, KRT8
15retinoid4410.6CDKN1A, MUC5AC, IFI27, KRT8, PGR, KRT7
16resveratrol44 59 11 2413.6PGR
17ribonucleic acid4410.6CXCL12, PGR, MUC5AC, CEACAM5, KRT20, NME1
185fluorouracil4410.6CDKN2A, MUC5AC, PGR, CXCL12, NME1, CEACAM7
19actinomycin d4410.6CEACAM7, KRT8, CXCL12, CDKN1B, CDKN2A, CDKN1A
20dexamethasone44 49 28 1113.6MUC16, MUC5AC, CDKN2A, CXCL12, CDKN1B, IFI27
21n-acetylglucosamine4410.6KRT7, KRT8, MUC5AC, CEACAM5
22hyaluronic acid44 2411.6CEACAM5, KRT20, CALB2, CXCL12, MUC16
23hematoxylin4410.6KRT8, MUC16, CEACAM5, KRT20, MUC5AC, CDKN2A
24methotrexate44 49 1112.6CDKN1B, MUC5AC, CDKN2A, PGR, KRT7
25paclitaxel44 49 1112.6CALB2, IFI27, MUC16, CDKN2A, CDKN1A, CDKN1B
26steroid4410.6IFI27, MUC5AC, CDKN2A, CDX2, CXCL12, NME1
27oligonucleotide4410.6MUC5AC, IFI27, CDKN2A, CDX2, CDKN1A, CDKN1B
28lovastatin44 49 59 28 1114.6CDKN1B, CDKN1A, IFI27, CDKN2A
29thymidine44 2411.6CEACAM5, CALB2, IFI27, CDX2, CDKN1A, CXCL12
30cisplatin44 49 59 1113.6KRT8, RASSF1, NME1, CDKN1B, CDKN1A, CDKN2A
31doxorubicin44 49 1112.6CDKN2A, KRT8, KRT20, PGR, CDKN1B, CDKN1A
32n acetylcysteine4410.6CDKN1B, CDKN2A, IFI27, MUC5AC, CDKN1A
33p0034410.6CEACAM5, IFI27, RASSF1, CDKN1B
34threonine4410.6RASSF1, CXCL12, CDKN1B, CDKN1A, CDKN2A, MUC5AC
35cytarabine44 49 1112.6CDKN1B, CDKN1A, CDKN2A, IFI27
36eb 108944 5911.5CDKN1A, IFI27, CDKN1B
37retinoic acid44 2411.5NME1, KRT7, PGR, CEACAM7, CDKN1B, CDKN1A
38testosterone44 59 11 2413.5KRT20, KRT7, CDKN2A, PGR, CDKN1B, KRT8
39vegf4410.5MUC16, IFI27, CXCL12, CDKN2A, CDKN1A, CDKN1B
40calcium44 49 11 2413.5IFI27, MUC5AC, CALB2, CDH3, CDX2, NME1
41serine4410.5RASSF1, CDKN1A, CDKN1B, CDKN2A, CXCL12, KRT8
42sialic acid4410.5CEACAM5, KRT7
43troglitazone44 28 59 1113.5KRT20, CDKN1B, CDKN1A, IFI27
44tyrosine4410.4CDX2, CDKN1B, KRT20, CDKN1A, CALB2, KRT7
45p000484410.4CDKN1A, IFI27
46paraffin4410.4CALB2, IFI27, MUC16, CDKN2A, MUC5AC, CDH3
47progesterone44 59 28 11 2414.3CEACAM5, MUC5AC, MUC16, IFI27, CALB2, NME1
48optimax4410.3CDKN1A, IFI27
49cysteine4410.2CEACAM5, KRT8, MUC5AC, PGR, CDKN2A, CDX2
50pd 98,0594410.0MUC5AC, CXCL12, CDKN1B, CDKN1A, IFI27

GO Terms for genes affiliated with Cervical Adenocarcinoma

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16Gene Ontology
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Cellular components related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.4KRT8, KRT20, KRT7

Biological processes related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.6CDKN1B, CDKN2A, CDKN1A
2negative regulation of phosphorylationGO:04232610.5CDKN2A, CDKN1B, CDKN1A
3cell cycle arrestGO:00705010.5CDKN2A, CDKN1A, CDKN1B, RASSF1
4negative regulation of gene expressionGO:01062910.4CDKN1A, PGR, NME1
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.4IFI27, CDKN2A, CDKN1B
6cell adhesionGO:00715510.4MUC16, MUC5AC, LAMC2, CDH3, CXCL12
7Ras protein signal transductionGO:00726510.3CDKN2A, RASSF1, CDKN1A
8mitotic cell cycle arrestGO:07185010.1CDKN1B, CDKN1A

Molecular functions related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.4CDKN1B, CDKN1A, CDKN2A

Products for genes affiliated with Cervical Adenocarcinoma

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  • Antibodies
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Sources for Cervical Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet