MCID: CRV031
MIFTS: 52

Cervical Adenocarcinoma malady

Reproductive diseases, Cancer diseases, Rare diseases categories

Summaries for Cervical Adenocarcinoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Cervical cancer is a cancer arising from the cervix. It is due to the abnormal growth of cells that have... more...

MalaCards: Cervical Adenocarcinoma, also known as adenocarcinoma of the uterine cervix, is related to adenocarcinoma and adenocarcinoma in situ. An important gene associated with Cervical Adenocarcinoma is CDX2 (caudal type homeobox 2), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and MicroRNAs in cancer. The compounds sodium bisulfite and 5-methylcytosine have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and testes, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Cervical Adenocarcinoma

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9Disease Ontology, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 41NCIt, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

cervical adenocarcinoma 9 46 50 63
adenocarcinoma of the uterine cervix 9
adenocarcinoma of the cervix uteri 50
adenocarcinoma cervix uteri 9
adenocarcinoma of cervix 9


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Disease Ontology9 DOID:3702
NCIt41 C4029
SNOMED-CT via Orphanet60 254887002
ICD10 via Orphanet27 C53

Related Diseases for Cervical Adenocarcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Cervical Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.3EBAG9, LAMC2, CXCL12, RASSF1, NME1, KRT8
2adenocarcinoma in situ31.3CDKN2A
3adenosquamous carcinoma30.5KRT8, NME1
4endometrial carcinoma30.2EBAG9, RASSF1, CDKN2A
5breast cancer30.2CXCL12, RASSF1, NME1, KRT8, CDX2, CDKN1B
6cervical intraepithelial neoplasia30.2NME1, KRT8, CDKN2A
7lung cancer30.0RASSF1, CDKN2A
8papilloma29.9CDKN1B, CDKN2A, RASSF1
9cervical squamous cell carcinoma29.8RASSF1, KRT8, CDKN2A, CDKN1B
10adenoma29.6EBAG9, LAMC2, RASSF1, NME1, KRT8, CDX2
11cervicitis11.2
12clear cell adenocarcinoma10.9
13papillary serous adenocarcinoma10.6
14mucinous adenocarcinoma10.6
15hemihypertrophy10.5
16early invasive cervical adenocarcinoma10.4
17endocervicitis10.4
18signet ring cell adenocarcinoma10.3
19bilateral breast cancer10.3
20endometriosis10.3
21pulmonary embolism10.3
22wilms tumor10.3
23glassy cell carcinoma of the cervix10.3
24endotheliitis10.3
25vaginitis10.2
26peutz-jeghers syndrome10.1
27influenza10.1
28papillary adenocarcinoma10.1
29monocytic leukemia10.1CXCL12
30neuroendocrine carcinoma10.0CDX2, KRT8
31barrett's esophagus10.0CDX2, CDKN2A
32leukoplakia10.0KRT8, NME1
33nasopharynx carcinoma10.0RASSF1, CDKN2A
34adenoid cystic carcinoma10.0KRT8, RASSF1
35synovial sarcoma10.0RASSF1, KRT8
36laryngeal squamous cell carcinoma10.0CDKN2A, NME1
37bladder carcinoma in situ10.0CDKN2A, RASSF1
38malignant mesothelioma10.0RASSF1, CDKN2A
39seminoma10.0NME1, RASSF1
40gastric adenocarcinoma10.0CDX2, KRT8, NME1
41neuroendocrine tumor10.0RASSF1, KRT8, CDX2
42breast fibroadenoma10.0RASSF1, NME1, KRT8
43oxyphilic adenoma10.0RASSF1, NME1, KRT8
44pancreatic cancer10.0CDKN2A, CDX2, KRT8
45intraocular melanoma10.0NME1, KRT8, CDKN2A
46adenoameloblastoma10.0CDKN1B, KRT8
47papillary thyroid carcinoma10.0RASSF1, CXCL12
48idiopathic pulmonary fibrosis10.0LAMC2, CXCL12
49lung small cell carcinoma10.0RASSF1, KRT8, CDKN2A
50cardiac tamponade10.0

Graphical network of the top 20 diseases related to Cervical Adenocarcinoma:



Diseases related to cervical adenocarcinoma

Symptoms for Cervical Adenocarcinoma

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Drugs & Therapeutics for Cervical Adenocarcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Cervical Adenocarcinoma

Search NIH Clinical Center for Cervical Adenocarcinoma

Search CenterWatch for Cervical Adenocarcinoma

Genetic Tests for Cervical Adenocarcinoma

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Anatomical Context for Cervical Adenocarcinoma

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34MalaCards
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MalaCards organs/tissues related to Cervical Adenocarcinoma:

34
Cervix, Lymph node, Testes, Colon, Ovary, Lung, Breast, Uterus

Animal Models for Cervical Adenocarcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Cervical Adenocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1RASSF1, NME1, CDX2, CDKN2A, CDKN1B
2MP:00053817.9LAMC2, KRT8, CDX2, CDKN2A, CDKN1B
3MP:00053857.7CDKN1B, CDX2, KRT8, RASSF1, CXCL12
4MP:00053707.6CXCL12, NME1, KRT8, CDKN2A, CDKN1B
5MP:00053897.4CXCL12, KRT8, CDX2, CDKN2A, CDKN1B
6MP:00053977.1EBAG9, CXCL12, NME1, KRT8, CDKN2A, CDKN1B
7MP:00053877.0EBAG9, LAMC2, CXCL12, RASSF1, KRT8, CDKN2A
8MP:00107686.6CDKN1B, LAMC2, CXCL12, RASSF1, NME1, KRT8

Publications for Cervical Adenocarcinoma

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53PubMed
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Articles related to Cervical Adenocarcinoma:

(show top 50)    (show all 246)
idTitleAuthorsYear
1
Human papillomavirus detected in a colonic metastasis of cervical adenocarcinoma. (23549714)
2013
2
Phase II trial on neoadjuvant intravenous and trans-uterine arterial chemotherapy for locally advanced bulky cervical adenocarcinoma. (23333929)
2013
3
Prevalence and type distribution of human papillomavirus in cervical adenocarcinoma in Korean women. (23485771)
2013
4
Cervical adenocarcinoma in a patient with Lynch syndrome, Muir-Torre variant. (22124091)
2012
5
Solitary cerebellous metastasis after prolonged remission in a case of uterine cervical adenocarcinoma. (22865975)
2012
6
Cervical adenocarcinoma in situ with negative conization margin: negligible or not? (21607088)
2011
7
Composite cervical adenocarcinoma composed of adenoma malignum and gastric type adenocarcinoma (dedifferentiated adenoma malignum) in a patient with Peutz Jeghers syndrome. (20876329)
2010
8
Metastatic carcinomas in the cervix mimicking primary cervical adenocarcinoma and adenocarcinoma in situ: report of a series of cases. (20414103)
2010
9
Postoperative adjuvant chemotherapy for node-positive cervical adenocarcinoma. (19396009)
2009
10
A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics. (19188825)
2009
11
Bulky scalp metastasis and superior sagittal sinus thrombosis from a cervical adenocarcinoma: an unusual case. (18373834)
2008
12
Comprehensive evaluation of CDX2 in invasive cervical adenocarcinomas: immunopositivity in the absence of overt colorectal morphology. (18753946)
2008
13
Correlation of CXCR4/CXCL12 overexpression to lymph node metastasis and chronic inflammation in cervical adenocarcinoma]. (17355795)
2007
14
Preserving fertility in invasive cervical adenocarcinoma by abdominal radical trachelectomy and pelvic lymphadenectomy. (17061618)
2006
15
Seminal plasma promotes the expression of tumorigenic and angiogenic genes in cervical adenocarcinoma cells via the E-series prostanoid 4 receptor. (16574793)
2006
16
Prevalence of human papillomavirus types 16 and 18 in cervical adenocarcinoma and its precursors in Scottish patients. (16803480)
2006
17
Is improved detection of adenocarcinoma in situ by screening a key to reducing the incidence of cervical adenocarcinoma? (15471248)
2004
18
Primary cervical adenocarcinoma with intestinal differentiation and colonic carcinoma metastatic to cervix: an investigation using Cdx-2 and a limited immunohistochemical panel. (14632574)
2003
19
Postconization surveillance of cervical adenocarcinoma in situ. A prospective trial. (14619639)
2003
20
Adenosquamous histology predicts poor outcome in low-risk stage IB1 cervical adenocarcinoma. (14675676)
2003
21
Cervical adenocarcinoma survival among Hispanic and white women: a multicenter cohort study. (12634634)
2003
22
Treatment of recurrent cervical adenocarcinoma with BMS-247550, an epothilone B analog. (12821348)
2003
23
Abdominal wall metastasis of a cervical adenocarcinoma at the laparoscopic trocar insertion site after ovarian transposition: case report and review of the literature. (12893216)
2003
24
Fas ligand expression in cervical adenocarcinoma: relevance to lymph node metastasis and tumor progression. (12821344)
2003
25
Pregnancy following radical trachelectomy and pelvic lymphadenectomy for Stage I cervical adenocarcinoma. (12174169)
2002
26
Endocervical curettage at conization to predict residual cervical adenocarcinoma in situ. (12468353)
2002
27
Stage IIB-IVB cervical adenocarcinoma: prognostic factors and survival. (11748986)
2002
28
Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas. (11499840)
2001
29
The significance of p53 codon 72 polymorphism for the development of cervical adenocarcinomas. (11710828)
2001
30
Beta-catenin expression as a prognostic indicator in cervical adenocarcinoma. (11562771)
2001
31
Neoadjuvant chemotherapy using low-dose consecutive intraarterial infusions of cisplatin combined with 5-fluorouracil for locally advanced cervical adenocarcinoma. (11371145)
2001
32
Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups: a population based study with review of all nonsquamous cervical carcinomas in Norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990. (11002225)
2000
33
Ovarian metastasis in stage IB and II cervical adenocarcinoma. (10419741)
1999
34
Clinical pathological analysis and immunohistochemical expression of primary cervical adenocarcinoma in 98 cases]. (11869532)
1999
35
Detection of human papillomavirus types in cervical adenocarcinoma by the polymerase chain reaction. (9989896)
1998
36
Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions. (9439892)
1997
37
Characterization and localization of mitochondrial oligopeptidase (MOP) (EC 3.4.24.16) activity in the human cervical adenocarcinoma cell line HeLa. (9257187)
1997
38
Analysis of response to radiation therapy of patients with cervical adenocarcinoma compared with squamous cell carcinoma. MIB-1 and PC10 labeling indices. (8635096)
1996
39
The human papillomavirus status of invasive cervical adenocarcinoma: a clinicopathological and outcome analysis. (7890285)
1995
40
Human papillomavirus detection in cervical adenocarcinoma by polymerase chain reaction. (8389316)
1993
41
Cervical adenocarcinoma and related lesions. Cytodiagnostic criteria and pitfalls. (8356007)
1993
42
Cervical adenocarcinoma or cervical extension. (8498460)
1993
43
Detection of HPV 16/18 DNA in cervical adenocarcinoma using polymerase chain reaction (PCR) methodology. (1311838)
1992
44
Absence of human papillomavirus in cervical adenocarcinoma. (1313458)
1992
45
Expression of c-myc, epidermal growth factor receptor and c-erbB-2 in human endometrial carcinoma and cervical adenocarcinoma. (1687493)
1991
46
The topography and invasive potential of cervical adenocarcinoma in situ, with and without associated squamous dysplasia. (2298414)
1990
47
Cervical adenocarcinoma in young women: possible relationship to microglandular hyperplasia and use of oral contraceptives. (2726119)
1989
48
Cervical adenocarcinoma in situ. (3285263)
1988
49
Analysis of the levels of CA125, carcinoembryonic antigen, and CA19-9 in the cervical mucus for a detection of cervical adenocarcinoma. (2455590)
1988
50
Brief recording. Cervical adenocarcinoma of mesonephric origin. (14438822)
1960

Variations for Cervical Adenocarcinoma

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Expression for genes affiliated with Cervical Adenocarcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Adenocarcinoma

Search GEO for disease gene expression data for Cervical Adenocarcinoma.

Pathways for genes affiliated with Cervical Adenocarcinoma

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Sources:
51PathCards, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
9.1CDKN1B, CDKN2A
28.7RASSF1, CDKN2A, CDKN1B
3
Show member pathways
Signaling Pathways in Glioblastoma39
8.7CDKN1B, CDKN2A, RASSF1
48.3CDKN1B, CDKN2A, RASSF1, LAMC2
5
Show member pathways
8.1CDKN1B, CDKN2A, CXCL12, LAMC2

Compounds for genes affiliated with Cervical Adenocarcinoma

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46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1sodium bisulfite469.8CDKN2A, RASSF1
25-methylcytosine46 2510.8CDKN2A, RASSF1
3o6-methylguanine469.8RASSF1, CDKN2A
4crcs469.5RASSF1, NME1, CDKN2A
5gold469.4CDKN2A, KRT8, LAMC2
6p00001469.4CDKN2A, CDKN1B
7ifn-alpha469.2CDKN2A, CXCL12
8matrigel469.2KRT8, NME1, CXCL12
9flavopiridol46 1210.1CDKN1B, CDKN2A
10hematoxylin469.1KRT8, CDKN2A
11gtp46 3010.0CDKN2A, NME1, CXCL12
12creatinine469.0CDKN2A, KRT8, NME1
13etoposide46 52 62 1212.0CDKN1B, KRT8, NME1
145-aza-2deoxycytidine469.0CDKN2A, CDX2, RASSF1, CXCL12
15cysteine468.9CDKN2A, CDX2, KRT8, NME1
16paclitaxel46 52 1210.8CDKN1B, CDKN2A, KRT8
17doxorubicin46 52 1210.8KRT8, CDKN2A, CDKN1B
18tamoxifen46 52 30 1211.8CDKN1B, KRT8, CXCL12
19fatty acid468.8NME1, CDX2, CDKN2A, CDKN1B
20pge2468.7CXCL12, NME1, CDKN1B
21butyrate468.7CDKN1B, CDKN2A, CDX2, KRT8
22thymidine46 259.7CXCL12, NME1, CDX2, CDKN1B
23alanine468.6RASSF1, NME1, CDKN2A, CDKN1B
245fluorouracil468.5CDKN1B, CDKN2A, NME1, CXCL12
25steroid468.5CXCL12, NME1, KRT8, CDX2, CDKN2A
26dexamethasone46 52 30 1211.4CXCL12, NME1, CDKN2A, CDKN1B
27actinomycin d468.4CXCL12, KRT8, CDKN2A, CDKN1B
28genistein46 30 62 3 25 1213.4CDKN1B, CDKN2A, KRT8, CXCL12
29cycloheximide468.3CXCL12, KRT8, CDKN2A, CDKN1B
30paraffin468.3NME1, KRT8, CDX2, CDKN2A, CDKN1B
31calcium46 52 25 1211.2CXCL12, NME1, KRT8, CDX2, CDKN2A
32agar468.2RASSF1, NME1, KRT8, CDKN2A, CDKN1B
33cisplatin46 52 62 1211.2RASSF1, NME1, KRT8, CDKN2A, CDKN1B
34retinoic acid46 259.1CDKN1B, CDKN2A, KRT8, NME1, RASSF1
35tyrosine468.1CXCL12, NME1, KRT8, CDX2, CDKN1B
36vegf468.0CXCL12, NME1, KRT8, CDKN2A, CDKN1B
37atp46 309.0CXCL12, NME1, KRT8, CDKN2A, CDKN1B
38threonine467.9CXCL12, RASSF1, KRT8, CDKN2A, CDKN1B
39oligonucleotide467.8RASSF1, NME1, KRT8, CDX2, CDKN2A, CDKN1B
40progesterone46 30 62 25 1211.7CXCL12, NME1, KRT8, CDX2, CDKN2A, CDKN1B
41serine467.5CXCL12, RASSF1, NME1, KRT8, CDKN2A, CDKN1B
42estrogen466.9CDKN1B, EBAG9, CXCL12, RASSF1, NME1, KRT8

GO Terms for genes affiliated with Cervical Adenocarcinoma

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17Gene Ontology
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Biological processes related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.2CDKN1B, CDKN2A
2Ras protein signal transductionGO:0072659.2CDKN2A, RASSF1
3negative regulation of phosphorylationGO:0423269.2CDKN1B, CDKN2A
4activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.1CDKN1B, CDKN2A
5response to peptide hormoneGO:0434349.0CXCL12, CDKN1B
6cell cycle arrestGO:0070508.8CDKN1B, CDKN2A, RASSF1
7negative regulation of cell proliferationGO:0082858.6CDKN1B, CDKN2A, NME1

Molecular functions related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.1CDKN1B, CDKN2A

Products for genes affiliated with Cervical Adenocarcinoma

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Sources for Cervical Adenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet