MCID: CRV031
MIFTS: 44

Cervical Adenocarcinoma malady

Reproductive diseases, Cancer diseases, Rare diseases categories

Summaries for Cervical Adenocarcinoma

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Disease Ontology:9 A cervix carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary: Cervical Adenocarcinoma, also known as adenocarcinoma of the uterine cervix, is related to adenocarcinoma in situ and adenosquamous carcinoma. An important gene associated with Cervical Adenocarcinoma is CDX2 (caudal type homeobox 2), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and MicroRNAs in cancer. The compounds sodium bisulfite and 5-methylcytosine have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and testes, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Cervical Adenocarcinoma

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Sources:
9Disease Ontology, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 38NCIt, 26ICD10 via Orphanet
See all sources

Cervical Adenocarcinoma, Aliases & Descriptions:

Name: Cervical Adenocarcinoma 9 43 47 60
Adenocarcinoma of the Uterine Cervix 9
Adenocarcinoma of the Cervix Uteri 47
 
Adenocarcinoma Cervix Uteri 9
Adenocarcinoma of Cervix 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:3702
NCIt38 C4029
Orphanet47 213772
ICD10 via Orphanet26 C53

Related Diseases for Cervical Adenocarcinoma

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Diseases related to Cervical Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma in situ31.8CDKN2A
2adenosquamous carcinoma30.7NME1, KRT8
3endometrial cancer30.5CDKN2A, RASSF1, EBAG9
4lung cancer30.3CDKN2A, RASSF1
5cervical intraepithelial neoplasia30.2NME1, CDKN2A, KRT8
6adenocarcinoma30.0KRT8, CDKN1B, CXCL12, RASSF1, NME1, CDX2
7papilloma29.8CDKN2A, CDKN1B, RASSF1
8nasopharyngeal carcinoma29.7CDKN2A, CXCL12, RASSF1, NME1
9breast cancer29.4CDX2, CDKN1B, KRT8, RASSF1, CXCL12, NME1
10adenoma28.5KRT8, CDX2, LAMC2, EBAG9, CDKN2A, CDKN1B
11cervicitis11.2
12papillary adenocarcinoma11.0
13clear cell adenocarcinoma10.9
14mucinous adenocarcinoma10.7
15papillary serous adenocarcinoma10.6
16early invasive cervical adenocarcinoma10.4
17endocervicitis10.4
18wilms tumor10.3
19endocervical adenocarcinoma10.3
20signet ring cell adenocarcinoma10.3
21bilateral breast cancer10.3
22endometriosis10.3
23pulmonary embolism10.3
24glassy cell carcinoma of the cervix10.3
25endotheliitis10.3
26monocytic leukemia10.2CXCL12
27vaginitis10.2
28neuroendocrine tumor10.2CDX2, KRT8
29barrett esophagus/esophageal adenocarcinoma10.2CDX2, CDKN2A
30leukoplakia10.2KRT8, NME1
31breast ductal carcinoma10.2KRT8, NME1
32nasopharynx carcinoma10.2CDKN2A, RASSF1
33salivary gland adenoid cystic carcinoma10.2KRT8, RASSF1
34sarcoma, synovial10.1KRT8, RASSF1
35peutz-jeghers syndrome10.1
36influenza10.1
37laryngeal squamous cell carcinoma10.1CDKN2A, NME1
38bladder cancer, somatic10.1CDKN2A, RASSF1
39mesothelioma, somatic10.1CDKN2A, RASSF1
40seminoma10.1NME1, RASSF1
41gastric adenocarcinoma10.1KRT8, CDX2, NME1
42tonsil cancer10.1CDKN1B, CDKN2A
43breast fibroadenoma10.0KRT8, NME1, RASSF1
44oxyphilic adenoma10.0NME1, RASSF1, KRT8
45pancreatic cancer10.0CDX2, KRT8, CDKN2A
46uveal melanoma10.0NME1, KRT8, CDKN2A
47ameloblastoma10.0KRT8, CDKN1B
48renal cell carcinoma10.0
49granuloma annulare10.0
50cardiac tamponade10.0

Graphical network of the top 20 diseases related to Cervical Adenocarcinoma:



Diseases related to cervical adenocarcinoma

Symptoms for Cervical Adenocarcinoma

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Drugs & Therapeutics for Cervical Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Cervical Adenocarcinoma

Search NIH Clinical Center for Cervical Adenocarcinoma

Genetic Tests for Cervical Adenocarcinoma

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Anatomical Context for Cervical Adenocarcinoma

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MalaCards organs/tissues related to Cervical Adenocarcinoma:

31
Cervix, Lymph node, Testes, Colon, Ovary, Uterus, Lung, Breast

Animal Models for Cervical Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Cervical Adenocarcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1RASSF1, NME1, CDX2, CDKN2A, CDKN1B
2MP:00053817.9LAMC2, KRT8, CDX2, CDKN2A, CDKN1B
3MP:00053857.7CDKN1B, CDX2, KRT8, RASSF1, CXCL12
4MP:00053707.6CXCL12, NME1, KRT8, CDKN2A, CDKN1B
5MP:00053897.4CXCL12, KRT8, CDX2, CDKN2A, CDKN1B
6MP:00053977.1EBAG9, CXCL12, NME1, KRT8, CDKN2A, CDKN1B
7MP:00053877.0EBAG9, LAMC2, CXCL12, RASSF1, KRT8, CDKN2A
8MP:00107686.6CDKN1B, LAMC2, CXCL12, RASSF1, NME1, KRT8

Publications for Cervical Adenocarcinoma

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Articles related to Cervical Adenocarcinoma:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
Methanolic Extracts from Brown Seaweeds Dictyota cilliolata and Dictyota menstrualis Induce Apoptosis in Human Cervical Adenocarcinoma HeLa Cells. (25871374)
2015
2
Ovarian preservation in young patients with stage I cervical adenocarcinoma: a surveillance, epidemiology, and end results study. (25188889)
2014
3
Human papillomavirus detected in a colonic metastasis of cervical adenocarcinoma. (23549714)
2013
4
Conservative treatment of uterine cervical adenocarcinoma in pregnancy. (24455354)
2013
5
High pathologic misdiagnosis of cervical adenocarcinoma in situ. (24475580)
2013
6
Phase II trial on neoadjuvant intravenous and trans-uterine arterial chemotherapy for locally advanced bulky cervical adenocarcinoma. (23333929)
2013
7
Cervical adenocarcinoma in a patient with Lynch syndrome, Muir-Torre variant. (22124091)
2012
8
Solitary cerebellous metastasis after prolonged remission in a case of uterine cervical adenocarcinoma. (22865975)
2012
9
Cervical adenocarcinoma in situ with negative conization margin: negligible or not? (21607088)
2011
10
Composite cervical adenocarcinoma composed of adenoma malignum and gastric type adenocarcinoma (dedifferentiated adenoma malignum) in a patient with Peutz Jeghers syndrome. (20876329)
2010
11
Metastatic carcinomas in the cervix mimicking primary cervical adenocarcinoma and adenocarcinoma in situ: report of a series of cases. (20414103)
2010
12
Postoperative adjuvant chemotherapy for node-positive cervical adenocarcinoma. (19396009)
2009
13
A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics. (19188825)
2009
14
Bulky scalp metastasis and superior sagittal sinus thrombosis from a cervical adenocarcinoma: an unusual case. (18373834)
2008
15
Comprehensive evaluation of CDX2 in invasive cervical adenocarcinomas: immunopositivity in the absence of overt colorectal morphology. (18753946)
2008
16
Preserving fertility in invasive cervical adenocarcinoma by abdominal radical trachelectomy and pelvic lymphadenectomy. (17061618)
2006
17
Seminal plasma promotes the expression of tumorigenic and angiogenic genes in cervical adenocarcinoma cells via the E-series prostanoid 4 receptor. (16574793)
2006
18
Prevalence of human papillomavirus types 16 and 18 in cervical adenocarcinoma and its precursors in Scottish patients. (16803480)
2006
19
Is improved detection of adenocarcinoma in situ by screening a key to reducing the incidence of cervical adenocarcinoma? (15471248)
2004
20
Primary cervical adenocarcinoma with intestinal differentiation and colonic carcinoma metastatic to cervix: an investigation using Cdx-2 and a limited immunohistochemical panel. (14632574)
2003
21
Postconization surveillance of cervical adenocarcinoma in situ. A prospective trial. (14619639)
2003
22
Adenosquamous histology predicts poor outcome in low-risk stage IB1 cervical adenocarcinoma. (14675676)
2003
23
Cervical adenocarcinoma survival among Hispanic and white women: a multicenter cohort study. (12634634)
2003
24
Treatment of recurrent cervical adenocarcinoma with BMS-247550, an epothilone B analog. (12821348)
2003
25
Abdominal wall metastasis of a cervical adenocarcinoma at the laparoscopic trocar insertion site after ovarian transposition: case report and review of the literature. (12893216)
2003
26
Fas ligand expression in cervical adenocarcinoma: relevance to lymph node metastasis and tumor progression. (12821344)
2003
27
Pregnancy following radical trachelectomy and pelvic lymphadenectomy for Stage I cervical adenocarcinoma. (12174169)
2002
28
Endocervical curettage at conization to predict residual cervical adenocarcinoma in situ. (12468353)
2002
29
Stage IIB-IVB cervical adenocarcinoma: prognostic factors and survival. (11748986)
2002
30
Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas. (11499840)
2001
31
The significance of p53 codon 72 polymorphism for the development of cervical adenocarcinomas. (11710828)
2001
32
Beta-catenin expression as a prognostic indicator in cervical adenocarcinoma. (11562771)
2001
33
Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups: a population based study with review of all nonsquamous cervical carcinomas in Norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990. (11002225)
2000
34
Ovarian metastasis in stage IB and II cervical adenocarcinoma. (10419741)
1999
35
Clinical pathological analysis and immunohistochemical expression of primary cervical adenocarcinoma in 98 cases]. (11869532)
1999
36
Detection of human papillomavirus types in cervical adenocarcinoma by the polymerase chain reaction. (9989896)
1998
37
Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions. (9439892)
1997
38
Analysis of response to radiation therapy of patients with cervical adenocarcinoma compared with squamous cell carcinoma. MIB-1 and PC10 labeling indices. (8635096)
1996
39
The human papillomavirus status of invasive cervical adenocarcinoma: a clinicopathological and outcome analysis. (7890285)
1995
40
Human papillomavirus detection in cervical adenocarcinoma by polymerase chain reaction. (8389316)
1993
41
Cervical adenocarcinoma and related lesions. Cytodiagnostic criteria and pitfalls. (8356007)
1993
42
Cervical adenocarcinoma or cervical extension. (8498460)
1993
43
Detection of HPV 16/18 DNA in cervical adenocarcinoma using polymerase chain reaction (PCR) methodology. (1311838)
1992
44
Expression of c-myc, epidermal growth factor receptor and c-erbB-2 in human endometrial carcinoma and cervical adenocarcinoma. (1687493)
1991
45
Deoxyribonucleic acid flow cytometric analysis of cervical adenocarcinoma: prognostic significance of deoxyribonucleic acid ploidy and S-phase fraction. (2316596)
1990
46
Cervical adenocarcinoma in young women: possible relationship to microglandular hyperplasia and use of oral contraceptives. (2726119)
1989
47
Cervical adenocarcinoma in situ. (3285263)
1988
48
Analysis of the levels of CA125, carcinoembryonic antigen, and CA19-9 in the cervical mucus for a detection of cervical adenocarcinoma. (2455590)
1988
49
Controversies in the management of cervical adenocarcinoma. (3393369)
1988
50
Brief recording. Cervical adenocarcinoma of mesonephric origin. (14438822)
1960

Variations for Cervical Adenocarcinoma

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Expression for genes affiliated with Cervical Adenocarcinoma

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Search GEO for disease gene expression data for Cervical Adenocarcinoma.

Pathways for genes affiliated with Cervical Adenocarcinoma

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Pathways related to Cervical Adenocarcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.1CDKN1B, CDKN2A
28.7RASSF1, CDKN2A, CDKN1B
3
Show member pathways
Signaling Pathways in Glioblastoma36
8.7CDKN1B, CDKN2A, RASSF1
48.3CDKN1B, CDKN2A, RASSF1, LAMC2
5
Show member pathways
8.1CDKN1B, CDKN2A, CXCL12, LAMC2

Compounds for genes affiliated with Cervical Adenocarcinoma

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Compounds related to Cervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 42)
idCompoundScoreTop Affiliating Genes
1sodium bisulfite439.8CDKN2A, RASSF1
25-methylcytosine43 2410.8CDKN2A, RASSF1
3o6-methylguanine439.8RASSF1, CDKN2A
4crcs439.5RASSF1, NME1, CDKN2A
5gold439.4CDKN2A, KRT8, LAMC2
6p00001439.4CDKN2A, CDKN1B
7ifn-alpha439.2CDKN2A, CXCL12
8matrigel439.2KRT8, NME1, CXCL12
9flavopiridol43 1210.1CDKN1B, CDKN2A
10hematoxylin439.1KRT8, CDKN2A
11gtp43 2810.0CDKN2A, NME1, CXCL12
12creatinine439.0CDKN2A, KRT8, NME1
13etoposide43 49 59 1212.0CDKN1B, KRT8, NME1
145-aza-2deoxycytidine439.0CDKN2A, CDX2, RASSF1, CXCL12
15cysteine438.9CDKN2A, CDX2, KRT8, NME1
16paclitaxel43 49 1210.8CDKN1B, CDKN2A, KRT8
17doxorubicin43 49 1210.8KRT8, CDKN2A, CDKN1B
18tamoxifen43 49 28 1211.8CDKN1B, KRT8, CXCL12
19fatty acid438.8NME1, CDX2, CDKN2A, CDKN1B
20pge2438.7CXCL12, NME1, CDKN1B
21butyrate438.7CDKN1B, CDKN2A, CDX2, KRT8
22thymidine43 249.7CXCL12, NME1, CDX2, CDKN1B
23alanine438.6RASSF1, NME1, CDKN2A, CDKN1B
245fluorouracil438.5CDKN1B, CDKN2A, NME1, CXCL12
25steroid438.5CXCL12, NME1, KRT8, CDX2, CDKN2A
26dexamethasone43 49 28 1211.4CXCL12, NME1, CDKN2A, CDKN1B
27actinomycin d438.4CXCL12, KRT8, CDKN2A, CDKN1B
28genistein43 28 59 2 24 1213.4CDKN1B, CDKN2A, KRT8, CXCL12
29cycloheximide438.3CXCL12, KRT8, CDKN2A, CDKN1B
30paraffin438.3NME1, KRT8, CDX2, CDKN2A, CDKN1B
31calcium43 49 24 1211.2CXCL12, NME1, KRT8, CDX2, CDKN2A
32agar438.2RASSF1, NME1, KRT8, CDKN2A, CDKN1B
33cisplatin43 49 59 1211.2RASSF1, NME1, KRT8, CDKN2A, CDKN1B
34retinoic acid43 249.1CDKN1B, CDKN2A, KRT8, NME1, RASSF1
35tyrosine438.1CXCL12, NME1, KRT8, CDX2, CDKN1B
36vegf438.0CXCL12, NME1, KRT8, CDKN2A, CDKN1B
37atp43 289.0CXCL12, NME1, KRT8, CDKN2A, CDKN1B
38threonine437.9CXCL12, RASSF1, KRT8, CDKN2A, CDKN1B
39oligonucleotide437.8RASSF1, NME1, KRT8, CDX2, CDKN2A, CDKN1B
40progesterone43 28 59 24 1211.7CXCL12, NME1, KRT8, CDX2, CDKN2A, CDKN1B
41serine437.5CXCL12, RASSF1, NME1, KRT8, CDKN2A, CDKN1B
42estrogen436.9CDKN1B, EBAG9, CXCL12, RASSF1, NME1, KRT8

GO Terms for genes affiliated with Cervical Adenocarcinoma

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Biological processes related to Cervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.2CDKN1B, CDKN2A
2Ras protein signal transductionGO:00072659.2CDKN2A, RASSF1
3negative regulation of phosphorylationGO:00423269.2CDKN1B, CDKN2A
4activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.1CDKN1B, CDKN2A
5response to peptide hormoneGO:00434349.0CXCL12, CDKN1B
6cell cycle arrestGO:00070508.8CDKN1B, CDKN2A, RASSF1
7negative regulation of cell proliferationGO:00082858.6CDKN1B, CDKN2A, NME1

Molecular functions related to Cervical Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.1CDKN1B, CDKN2A

Products for genes affiliated with Cervical Adenocarcinoma

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Sources for Cervical Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet