MCID: CRV031
MIFTS: 56

Cervical Adenocarcinoma malady

Reproductive diseases, Cancer diseases categories

Summaries for Cervical Adenocarcinoma

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MalaCards: Cervical Adenocarcinoma, also known as adenocarcinoma of the uterine cervix, is related to adenocarcinoma and papillary adenocarcinoma. An important gene associated with Cervical Adenocarcinoma is CDH3 (cadherin 3, type 1, P-cadherin (placental)), and among its related pathways are Glioma and Chronic myeloid leukemia. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and testes, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Cervical Adenocarcinoma

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8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

cervical adenocarcinoma 8 44 48 60
adenocarcinoma of the uterine cervix 8
adenocarcinoma of the cervix uteri 48
adenocarcinoma cervix uteri 8
adenocarcinoma of cervix 8


External Ids:

Disease Ontology8 DOID:3702
NCIt39 C4029
SNOMED-CT via Orphanet57 254887002
ICD10 via Orphanet26 C53

Related Diseases for Cervical Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Cervical Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
2papillary adenocarcinoma31.4CEACAM5, NME1, MUC16
3adenocarcinoma in situ31.1CDKN2A
4cervical squamous cell carcinoma30.6CEACAM5, KRT8, RASSF1, CDKN1B, CDKN1A, CDKN2A
5squamous cell carcinoma30.6CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
6adenosquamous carcinoma30.4CEACAM5, CEACAM7, KRT8, KRT20, KRT7, NME1
7signet ring cell adenocarcinoma30.4CEACAM5, KRT20, KRT7
8endometriosis30.4PGR, CDH3, MUC16, EBAG9, CALB2
9breast cancer30.4CEACAM5, CEACAM7, KRT8, KRT7, RASSF1, NME1
10endometrial carcinoma30.2RASSF1, PGR, CDH3, CDKN2A, MUC16, EBAG9
11cervical cancer30.2KRT8, RASSF1, NME1, CDKN1B, CDKN1A, CDKN2A
12gastric adenocarcinoma30.2CEACAM5, CEACAM7, KRT8, KRT20, KRT7, NME1
13colon adenocarcinoma30.1CEACAM5, CEACAM7, KRT20, CDKN1B, CDKN1A, MUC5AC
14peritonitis29.9MUC16
15sarcoma29.9LAMC2, KRT8, CALB2
16papilloma29.9KRT20, RASSF1, CDKN1B, CDKN1A, CDKN2A, IFI27
17lung cancer29.9CEACAM5, CEACAM7, KRT20, KRT7, NME1, CDKN1A
18clear cell adenocarcinoma29.9MUC16, IFI27
19lung adenocarcinoma29.9CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
20adenoma29.9CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
21cervicitis11.1
22papillary serous adenocarcinoma10.6
23early invasive cervical adenocarcinoma10.4
24endocervicitis10.3
25cervical adenosquamous carcinoma10.3
26cervix endometriosis10.3
27bilateral breast cancer10.3
28pulmonary embolism10.3
29glassy cell carcinoma of the cervix10.3
30endometrial adenocarcinoma10.2
31in situ carcinoma10.2
32vaginitis10.2
33mucinous adenocarcinoma10.1
34peutz-jeghers syndrome10.1
35breast adenocarcinoma10.1
36cervical mucinous adenocarcinoma10.1
37influenza10.1
38ovary adenocarcinoma10.1
39esophagitis10.0CDX2
40cystadenoma10.0KRT7
41teratoma10.0KRT7
42ductal carcinoma in situ10.0PGR
43stomach cancer10.0CDX2
44leiomyoma10.0PGR
45rhabdomyosarcoma10.0CALB2
46secretory meningioma10.0KRT7
47gastrointestinal stromal tumor10.0IFI27
48pituitary adenoma10.0CDKN1B, CDH3, IFI27
49meningioma10.0PGR, CALB2
50liver cirrhosis10.0KRT8

Graphical network of the top 20 diseases related to Cervical Adenocarcinoma:



Diseases related to cervical adenocarcinoma

Clinical Features for Cervical Adenocarcinoma

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Drugs & Therapeutics for Cervical Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Cervical Adenocarcinoma

Search NIH Clinical Center for Cervical Adenocarcinoma

Search CenterWatch for Cervical Adenocarcinoma

Genetic Tests for Cervical Adenocarcinoma

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Anatomical Context for Cervical Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Cervical Adenocarcinoma:

32
Cervix, Lymph node, Testes, Colon, Breast, Ovary, Prostate, Lung, Thyroid, Salivary gland, Uterus

Animal Models for Cervical Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cervical Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.4RASSF1, CDKN2A, CDX2, CDKN1A, CDKN1B, PGR
2MP:000538110.3MUC5AC, CDKN2A, CDX2, CDKN1A, CDKN1B, KRT8
3MP:000537910.3CDKN2A, CDH3, CDX2, CDKN1A, CDKN1B, NME1
4MP:000538710.3EBAG9, MUC5AC, CDKN2A, CDKN1A, CDKN1B, PGR
5MP:001077110.2CDKN2A, CDH3, CDKN1A, CDKN1B, NME1
6MP:000539710.2CDKN2A, CDKN1A, CDKN1B, PGR, CXCL12, NME1
7MP:000537010.0CDKN2A, CDKN1A, CDKN1B, CXCL12, NME1, KRT8

Publications for Cervical Adenocarcinoma

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50PubMed
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Articles related to Cervical Adenocarcinoma:

(show top 50)    (show all 324)
idTitleAuthorsYear
1
Protection against squamous cell carcinoma and cervical adenocarcinoma afforded by cervical cytology screening: a cross-sectional study. (24407579)
2014
2
Phase II trial on neoadjuvant intravenous and trans-uterine arterial chemotherapy for locally advanced bulky cervical adenocarcinoma. (23333929)
2013
3
Estimate of the global burden of cervical adenocarcinoma and potential impact of prophylactic human papillomavirus vaccination. (24261839)
2013
4
Human papillomavirus-unrelated gastric type of cervical adenocarcinoma presenting with a metastatic ovarian tumor: report of a case. (23343707)
2013
5
Results of cytology and high-risk human papillomavirus testing in females with cervical adenocarcinoma in situ. (23946807)
2013
6
Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma. (23707988)
2013
7
Prognostic impact of histology in patients with cervical squamous cell carcinoma, adenocarcinoma and small cell neuroendocrine carcinoma. (24175825)
2013
8
Cervical intraepithelial neoplasia grade 3 and adenocarcinoma in situ: comparison of ICD-9 codes and pathology results--Kaiser Permanente, United States, 2000-2005. (23563889)
2013
9
The poorer survival of patients with cervical adenocarcinoma and adenosquamous cell carcinoma compared to those with squamous cell carcinoma might be improved by a different treatment. (22735787)
2012
10
Biological and clinical significance of NAC1 expression in cervical carcinomas: a comparative study between squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas. (21889186)
2012
11
Ovarian recurrence from a Stage 1b1 cervical adenocarcinoma previously treated with radical vaginal trachelectomy: A case report. (24371615)
2012
12
Cervical adenocarcinoma presenting as a cardiac tamponade in a 57-year-old woman: a case report. (22188664)
2011
13
Papanicolaou tests associated with cervical mucosal endometriosis: an analysis of cellular features and comparison to endocervical adenocarcinoma in situ. (19937768)
2010
14
Digital colposcopy for the diagnosis of cervical adenocarcinoma using a narrow band imaging system. (20686380)
2010
15
Cervical adenocarcinoma resembling breast lobular carcinoma: a hitherto Undescribed Variant of Primary Cervical Adenocarcinoma. (20881849)
2010
16
Discrepancies in expression and prognostic value of tumor markers in adenocarcinoma and squamous cell carcinoma in cervical cancer. (19596931)
2009
17
Cervical adenocarcinoma metastatic to the ovary mimicking primary ovarian carcinoma. (19404859)
2009
18
Pulmonary metastases from cervical adenocarcinoma regress to a 'hole' lot of nothing. (19333074)
2009
19
Comprehensive evaluation of CDX2 in invasive cervical adenocarcinomas: immunopositivity in the absence of overt colorectal morphology. (18753946)
2008
20
Antiproliferative effects of the major tea polyphenol, (-)-epigallocatechin gallate and retinoic acid in cervical adenocarcinoma. (18035403)
2008
21
Correlation of CXCR4/CXCL12 overexpression to lymph node metastasis and chronic inflammation in cervical adenocarcinoma]. (17355795)
2007
22
CXCR4 expression is associated with pelvic lymph node metastasis in cervical adenocarcinoma. (17504381)
2007
23
Asymptomatic primary peritoneal carcinoma presenting as adenocarcinoma on routine cervical cytology. (16553187)
2006
24
Cytological study of early cervical adenocarcinoma: special reference to the depth of invasion. (16303042)
2005
25
Loss of heterozygosity analysis in uterine cervical adenocarcinoma. (15262128)
2004
26
Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas. (15492784)
2004
27
Neoadjuvant chemotherapy with cisplatin, aclacinomycin A, and mitomycin C for cervical adenocarcinoma--a preliminary study. (15228422)
2004
28
Correlation between responsiveness of neoadjuvant chemotherapy and apoptosis-associated proteins for cervical adenocarcinoma. (14751172)
2004
29
Postconization surveillance of cervical adenocarcinoma in situ. A prospective trial. (14619639)
2003
30
Infrared spectral features of exfoliated cervical cells, cervical adenocarcinoma tissue, and an adenocarcinoma cell line (SiSo). By Neviliappan S, et al. (14529695)
2003
31
Comparison of morphologic and immunohistochemical features of cervical microglandular hyperplasia with low-grade mucinous adenocarcinoma of the endometrium. (12819393)
2003
32
Clinicopathological study of the pattern and significance of cervical involvement in cases of endometrial adenocarcinoma. (11860535)
2002
33
Cervical implant from villoglandular endometrial adenocarcinoma masquerading as cervical villoglandular adenocarcinoma. (12060454)
2002
34
Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas. (11499840)
2001
35
Beta-catenin expression as a prognostic indicator in cervical adenocarcinoma. (11562771)
2001
36
Remission of metastatic cervical adenocarcinoma with weekly paclitaxel. (11328417)
2001
37
Prevalence of human papillomavirus DNA in different histological subtypes of cervical adenocarcinoma. (11021808)
2000
38
The definition of stage IA(1) cervical adenocarcinoma and selection criteria for nonradical surgical management. (10785493)
2000
39
Cervical cytology and immunohistochemical features in endometrial adenocarcinoma simulating microglandular hyperplasia. A case report. (10934963)
2000
40
Clinical value of tumor markers for early detection of recurrence in patients with cervical adenocarcinoma and adenosquamous carcinoma. (11006578)
2000
41
Evaluation of immunostaining for MIB1 and nm23 products in uterine cervical adenocarcinoma. (9823779)
1998
42
Cloning and characterization of a cDNA fragment coding beta-casein- like protein preferentially expressed in cervical adenocarcinoma cell line CAC-1. (9500206)
1998
43
Uterine cervical clear-cell adenocarcinoma with a choriocarcinomatous component: a case report. (8987325)
1996
44
Metastasis from a stage IB cervical adenocarcinoma in a transposed ovary: a case report and review of the literature. (7835790)
1994
45
Cervical adenocarcinoma or cervical extension. (8498460)
1993
46
The topography and invasive potential of cervical adenocarcinoma in situ, with and without associated squamous dysplasia. (2298414)
1990
47
Basement membrane of cervical adenocarcinoma: an immunoperoxidase study of laminin and type IV collagen. (2234709)
1990
48
Analysis of the levels of CA125, carcinoembryonic antigen, and CA19-9 in the cervical mucus for a detection of cervical adenocarcinoma. (2455590)
1988
49
Controversies in the management of cervical adenocarcinoma. (3393369)
1988
50
Vaginal and cervical abnormalities, including clear-cell adenocarcinoma, related to prenatal exposure to stilbestrol. (4460850)
1974

Genetic Variations for Cervical Adenocarcinoma

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Expression for genes affiliated with Cervical Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Adenocarcinoma

Search GEO for disease gene expression data for Cervical Adenocarcinoma.

Pathways for genes affiliated with Cervical Adenocarcinoma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore
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Pathways related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CDKN1A
2
Hide members
10.4CDKN1B, CDKN1A, CDKN2A
310.4CDKN1B, CDKN1A, CDKN2A
410.4CDKN1B, CDKN1A, CDKN2A
5
Hide members
10.4CDKN2A, CDKN1A, CDKN1B
6
Hide members
10.4CDKN1B, CDKN1A, CDKN2A
710.4CDKN2A, CDKN1A, CDKN1B, RASSF1
8
Cell cycle Cell cycle (generic schema)
Hide members
10.4PGR, CDKN1B, CDKN1A, CDKN2A
9
Hide members
10.4CDKN1A, CDKN1B, PGR, CXCL12
1010.3CDKN2A, CDKN1A, CDKN1B, RASSF1, LAMC2
11
Hide members
10.3CDKN2A, CDH3, CDKN1A, CDKN1B, CXCL12, LAMC2

Compounds for genes affiliated with Cervical Adenocarcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CEACAM7, CALB2
2butyrate4410.8CDX2, CEACAM7, CALB2
3crcs4410.7CEACAM5, NME1, CDKN2A, RASSF1
4cycloheximide4410.7CXCL12, KRT8, CEACAM7
5mucicarmine4410.7CEACAM7, KRT7, KRT20, CEACAM5, CALB2
6gefitinib44 49 1112.7IFI27, CEACAM5, CDKN1B, CDKN1A, CEACAM7
7gold4410.7MUC16, KRT8, LAMC2, CEACAM5
8estradiol44 11 2412.7MUC16, PGR, CEACAM5
9adriamycin4410.7CEACAM5, CDKN2A, CDKN1A, PGR, KRT8
105-aza-2deoxycytidine4410.7CXCL12, RASSF1, CDKN2A, CDX2, CDKN1A, KRT7
11agar4410.7CEACAM5, KRT8, RASSF1, NME1, PGR, CDKN1A
12b 7234410.6CALB2, MUC16, KRT8, CEACAM5, CEACAM7, KRT20
13genistein44 28 59 2 11 2415.6IFI27, CDKN1B, KRT8, CXCL12, PGR, CDKN1A
14tamoxifen44 49 28 1113.6CXCL12, IFI27, CDKN1A, CDKN1B, PGR, KRT8
15retinoid4410.6CDKN1A, MUC5AC, IFI27, KRT8, PGR, KRT7
16resveratrol44 59 11 2413.6PGR
17ribonucleic acid4410.6CXCL12, PGR, MUC5AC, CEACAM5, KRT20, NME1
185fluorouracil4410.6CDKN2A, MUC5AC, PGR, CXCL12, NME1, CEACAM7
19actinomycin d4410.6CEACAM7, KRT8, CXCL12, CDKN1B, CDKN2A, CDKN1A
20dexamethasone44 49 28 1113.6MUC16, MUC5AC, CDKN2A, CXCL12, CDKN1B, IFI27
21n-acetylglucosamine4410.6KRT7, KRT8, MUC5AC, CEACAM5
22hyaluronic acid44 2411.6CEACAM5, KRT20, CALB2, CXCL12, MUC16
23hematoxylin4410.6KRT8, MUC16, CEACAM5, KRT20, MUC5AC, CDKN2A
24methotrexate44 49 1112.6CDKN1B, MUC5AC, CDKN2A, PGR, KRT7
25paclitaxel44 49 1112.6CALB2, IFI27, MUC16, CDKN2A, CDKN1A, CDKN1B
26steroid4410.6IFI27, MUC5AC, CDKN2A, CDX2, CXCL12, NME1
27oligonucleotide4410.6MUC5AC, IFI27, CDKN2A, CDX2, CDKN1A, CDKN1B
28lovastatin44 49 59 28 1114.6CDKN1B, CDKN1A, IFI27, CDKN2A
29thymidine44 2411.6CEACAM5, CALB2, IFI27, CDX2, CDKN1A, CXCL12
30cisplatin44 49 59 1113.6KRT8, RASSF1, NME1, CDKN1B, CDKN1A, CDKN2A
31doxorubicin44 49 1112.6CDKN2A, KRT8, KRT20, PGR, CDKN1B, CDKN1A
32n acetylcysteine4410.6CDKN1B, CDKN2A, IFI27, MUC5AC, CDKN1A
33p0034410.6CEACAM5, IFI27, RASSF1, CDKN1B
34threonine4410.6RASSF1, CXCL12, CDKN1B, CDKN1A, CDKN2A, MUC5AC
35cytarabine44 49 1112.6CDKN1B, CDKN1A, CDKN2A, IFI27
36eb 108944 5911.5CDKN1A, IFI27, CDKN1B
37retinoic acid44 2411.5NME1, KRT7, PGR, CEACAM7, CDKN1B, CDKN1A
38testosterone44 59 11 2413.5KRT20, KRT7, CDKN2A, PGR, CDKN1B, KRT8
39vegf4410.5MUC16, IFI27, CXCL12, CDKN2A, CDKN1A, CDKN1B
40calcium44 49 11 2413.5IFI27, MUC5AC, CALB2, CDH3, CDX2, NME1
41serine4410.5RASSF1, CDKN1A, CDKN1B, CDKN2A, CXCL12, KRT8
42sialic acid4410.5CEACAM5, KRT7
43troglitazone44 28 59 1113.5KRT20, CDKN1B, CDKN1A, IFI27
44tyrosine4410.4CDX2, CDKN1B, KRT20, CDKN1A, CALB2, KRT7
45p000484410.4CDKN1A, IFI27
46paraffin4410.4CALB2, IFI27, MUC16, CDKN2A, MUC5AC, CDH3
47progesterone44 59 28 11 2414.3CEACAM5, MUC5AC, MUC16, IFI27, CALB2, NME1
48optimax4410.3CDKN1A, IFI27
49cysteine4410.2CEACAM5, KRT8, MUC5AC, PGR, CDKN2A, CDX2
50pd 98,0594410.0MUC5AC, CXCL12, CDKN1B, CDKN1A, IFI27

GO Terms for genes affiliated with Cervical Adenocarcinoma

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16Gene Ontology
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Cellular components related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.4KRT8, KRT20, KRT7

Biological processes related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.6CDKN1B, CDKN1A, CDKN2A
2negative regulation of phosphorylationGO:04232610.5CDKN1B, CDKN1A, CDKN2A
3cell cycle arrestGO:00705010.5CDKN2A, CDKN1A, CDKN1B, RASSF1
4negative regulation of gene expressionGO:01062910.4NME1, PGR, CDKN1A
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.4CDKN1B, CDKN2A, IFI27
6cell adhesionGO:00715510.4MUC16, MUC5AC, CDH3, CXCL12, LAMC2
7Ras protein signal transductionGO:00726510.3CDKN2A, CDKN1A, RASSF1
8mitotic cell cycle arrestGO:07185010.1CDKN1B, CDKN1A

Molecular functions related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.4CDKN1B, CDKN1A, CDKN2A

Products for genes affiliated with Cervical Adenocarcinoma

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  • Antibodies
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Sources for Cervical Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet