MCID: CRV031
MIFTS: 56

Cervical Adenocarcinoma malady

Reproductive diseases, Cancer diseases categories

Summaries for Cervical Adenocarcinoma

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MalaCards: Cervical Adenocarcinoma, also known as adenocarcinoma of the uterine cervix, is related to adenocarcinoma and papillary adenocarcinoma. An important gene associated with Cervical Adenocarcinoma is CDH3 (cadherin 3, type 1, P-cadherin (placental)), and among its related pathways are Glioma and Chronic myeloid leukemia. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and testes, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Cervical Adenocarcinoma

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8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

cervical adenocarcinoma 8 44 48 60
adenocarcinoma of the uterine cervix 8
adenocarcinoma of the cervix uteri 48
adenocarcinoma cervix uteri 8
adenocarcinoma of cervix 8


External Ids:

Disease Ontology8 DOID:3702
NCIt39 C4029
SNOMED-CT via Orphanet57 254887002
ICD10 via Orphanet26 C53

Related Diseases for Cervical Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Cervical Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
2papillary adenocarcinoma31.4CEACAM5, NME1, MUC16
3adenocarcinoma in situ31.1CDKN2A
4cervical squamous cell carcinoma30.6CEACAM5, KRT8, RASSF1, CDKN1B, CDKN1A, CDKN2A
5squamous cell carcinoma30.6CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
6adenosquamous carcinoma30.4CEACAM5, CEACAM7, KRT8, KRT20, KRT7, NME1
7signet ring cell adenocarcinoma30.4CEACAM5, KRT20, KRT7
8endometriosis30.4PGR, CDH3, MUC16, EBAG9, CALB2
9breast cancer30.4CEACAM5, CEACAM7, KRT8, KRT7, RASSF1, NME1
10endometrial carcinoma30.2RASSF1, PGR, CDH3, CDKN2A, MUC16, EBAG9
11cervical cancer30.2KRT8, RASSF1, NME1, CDKN1B, CDKN1A, CDKN2A
12gastric adenocarcinoma30.2CEACAM5, CEACAM7, KRT8, KRT20, KRT7, NME1
13colon adenocarcinoma30.1CEACAM5, CEACAM7, KRT20, CDKN1B, CDKN1A, MUC5AC
14peritonitis29.9MUC16
15sarcoma29.9LAMC2, KRT8, CALB2
16papilloma29.9KRT20, RASSF1, CDKN1B, CDKN1A, CDKN2A, IFI27
17lung cancer29.9CEACAM5, CEACAM7, KRT20, KRT7, NME1, CDKN1A
18clear cell adenocarcinoma29.9MUC16, IFI27
19lung adenocarcinoma29.9CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
20adenoma29.9CEACAM5, CEACAM7, LAMC2, KRT8, KRT20, KRT7
21cervicitis11.1
22papillary serous adenocarcinoma10.6
23early invasive cervical adenocarcinoma10.4
24endocervicitis10.3
25cervical adenosquamous carcinoma10.3
26cervix endometriosis10.3
27bilateral breast cancer10.3
28pulmonary embolism10.3
29glassy cell carcinoma of the cervix10.3
30endometrial adenocarcinoma10.2
31in situ carcinoma10.2
32vaginitis10.2
33mucinous adenocarcinoma10.1
34peutz-jeghers syndrome10.1
35breast adenocarcinoma10.1
36cervical mucinous adenocarcinoma10.1
37influenza10.1
38ovary adenocarcinoma10.1
39esophagitis10.0CDX2
40cystadenoma10.0KRT7
41teratoma10.0KRT7
42ductal carcinoma in situ10.0PGR
43stomach cancer10.0CDX2
44leiomyoma10.0PGR
45rhabdomyosarcoma10.0CALB2
46secretory meningioma10.0KRT7
47gastrointestinal stromal tumor10.0IFI27
48pituitary adenoma10.0CDKN1B, CDH3, IFI27
49meningioma10.0PGR, CALB2
50liver cirrhosis10.0KRT8

Graphical network of the top 20 diseases related to Cervical Adenocarcinoma:



Diseases related to cervical adenocarcinoma

Clinical Features for Cervical Adenocarcinoma

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Drugs & Therapeutics for Cervical Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Cervical Adenocarcinoma

Search NIH Clinical Center for Cervical Adenocarcinoma

Search CenterWatch for Cervical Adenocarcinoma

Genetic Tests for Cervical Adenocarcinoma

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Anatomical Context for Cervical Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Cervical Adenocarcinoma:

32
Cervix, Lymph node, Testes, Colon, Breast, Ovary, Prostate, Lung, Thyroid, Salivary gland, Uterus

Animal Models for Cervical Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cervical Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.4RASSF1, CDKN2A, CDX2, CDKN1A, CDKN1B, PGR
2MP:000538110.3MUC5AC, CDKN2A, CDX2, CDKN1A, CDKN1B, KRT8
3MP:000537910.3CDKN2A, CDH3, CDX2, CDKN1A, CDKN1B, NME1
4MP:000538710.3EBAG9, MUC5AC, CDKN2A, CDKN1A, CDKN1B, PGR
5MP:001077110.2CDKN2A, CDH3, CDKN1A, CDKN1B, NME1
6MP:000539710.2CDKN2A, CDKN1A, CDKN1B, PGR, CXCL12, NME1
7MP:000537010.0CDKN2A, CDKN1A, CDKN1B, CXCL12, NME1, KRT8

Publications for Cervical Adenocarcinoma

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50PubMed
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Articles related to Cervical Adenocarcinoma:

(show top 50)    (show all 324)
idTitleAuthorsYear
1
High Methylation Rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 Genes in Cervical Adenocarcinoma. (24407576)
2014
2
Intradural extramedullary colorectal adenocarcinoma metastasis to the cervical spine. (24251887)
2013
3
Long-term follow-up results from women with cervical adenocarcinoma in situ treated by conization: an experience from a large academic women's hospital. (23903202)
2013
4
Mifepristone sensitizing cisplatin for cervical adenocarcinoma HeLa cell sensitivity to chemotherapy and its mechanism. (23781585)
2013
5
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. (23651629)
2013
6
Cervical conization of adenocarcinoma in situ: a predicting model of residual disease. (24370689)
2013
7
Antiproliferative in vitro effects of BI 2536-mediated PLK1 inhibition on cervical adenocarcinoma cells. (22080235)
2013
8
Resistance of cervical adenocarcinoma cells (HeLa) to venom from the scorpion Centruroides limpidus limpidus. (24004568)
2013
9
Predictors of invasive adenocarcinoma after conization for cervical adenocarcinoma in situ. (22410327)
2012
10
Cervical adenocarcinoma in situ with negative conization margin: negligible or not? (21607088)
2011
11
P53 codon 72 and p21 codon 31 polymorphisms and susceptibility to cervical adenocarcinoma in Korean women. (20524403)
2010
12
Image of the month. Use of magnifying endoscopy to identify early esophageal adenocarcinoma in ectopic gastric mucosa of the cervical esophagus. (20347051)
2010
13
Cervical adenocarcinoma and squamous cell carcinoma incidence trends among Tunisian women. (21039053)
2010
14
Postoperative adjuvant chemotherapy for node-positive cervical adenocarcinoma. (19396009)
2009
15
Human papillomavirus-specific genotypes in cervical lesions of women referred for smears with atypical glandular cells or adenocarcinoma in situ. (19620946)
2009
16
Methylation analysis of SFRP genes family in cervical adenocarcinoma. (19513747)
2009
17
Increase in cervical adenocarcinoma rate in GoiAcnia, GO, Brazil. (19509573)
2009
18
Factors predicting tumour regression in locally advanced cervical adenocarcinoma treated with balloon-occluded intra-arterial chemotherapy. (18628334)
2008
19
Synchronous high-grade squamous intraepithelial lesion and adenocarcinoma in situ of cervix in a young woman presenting with hyperchromatic crowded groups in the cervical cytology specimen: report of a case. (18831021)
2008
20
Abnormal fragile histidine triad (Fhit) expression in invasive cervical adenocarcinoma: association with tumor aggressiveness. (17137614)
2007
21
Can adenocarcinoma in situ of the uterine cervix be predicted before cervical conization? (17250421)
2006
22
Role of adnexectomy in the surgical treatment of cervical adenocarcinoma. (16174256)
2005
23
Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literature. (16132512)
2005
24
Fas ligand expression in cervical adenocarcinoma: relevance to lymph node metastasis and tumor progression. (12821344)
2003
25
Mucinous adenocarcinoma and strumal carcinoid tumor arising in one mature cystic teratoma of the ovary with synchronous cervical cancer. (12696624)
2003
26
Uterine tumor resembling ovarian sex-cord tumor: report of a case mimicking cervical adenocarcinoma. (12819400)
2003
27
Early-stage cervical adenocarcinoma treated by surgical intent: the role of para-aortic lymph node dissection. (11812088)
2002
28
The significance of p53 codon 72 polymorphism for the development of cervical adenocarcinomas. (11710828)
2001
29
Atypical glandular cells of undetermined significance in cervical smears after conization. Cytologic features differentiating them from adenocarcinoma in situ. (11284300)
2001
30
Is the invasion depth in millimeters valid to determine the prognosis of early invasive cervical adenocarcinoma? A case of recurrent FIGO stage IA1 cervical adenocarcinoma. (11426988)
2001
31
Immunohistochemical analysis of cyclin D1 in cervical adenocarcinoma]. (10789011)
2000
32
Adenocarcinoma in situ with a small cell (endometrioid) pattern in cervical smears: a test of the distinction from benign mimics using specific criteria. (10536349)
1999
33
Ovarian metastasis in stage IB and II cervical adenocarcinoma. (10419741)
1999
34
DCC expression is related to mucinous differentiation but not changes in expression of p21(WAF1/Cip1) and p27Kip1, apoptosis, cell proliferation and human papillomavirus infection in uterine cervical adenocarcinomas. (10389977)
1999
35
MRI of cervical adenocarcinoma with cystic components. (10332598)
1999
36
Heterotopic salivary gland adenocarcinoma in the cervical region. (9258723)
1997
37
Analysis of response to radiation therapy of patients with cervical adenocarcinoma compared with squamous cell carcinoma. MIB-1 and PC10 labeling indices. (8635096)
1996
38
Effects of single and combined application of anti-cancer drugs on cervical adenocarcinoma. I. Antitumor activity in vitro. (7778422)
1995
39
Long-term follow-up of stage I cervical adenocarcinoma treated by radical surgery. (8314148)
1994
40
Cervical adenocarcinoma and related lesions. Cytodiagnostic criteria and pitfalls. (8356007)
1993
41
The correlation between HPV infection and cell proliferative activity in uterine cervical adenocarcinoma. (7902617)
1993
42
Detection of HPV 16/18 DNA in cervical adenocarcinoma using polymerase chain reaction (PCR) methodology. (1311838)
1992
43
Widespread granuloma annulare and cervical adenocarcinoma. (1296612)
1992
44
Cervical adenocarcinoma. (1321028)
1992
45
Predominance of serum antibodies to synthetic peptide stemming from HPV 18 open reading frame E2 in cervical adenocarcinoma. (1320634)
1992
46
Cervical adenocarcinoma in women with nasopharyngeal carcinoma (NPC). (2758388)
1989
47
The anatomic distribution of cervical adenocarcinoma in situ: implications for treatment. (3605256)
1987
48
Immunohistochemical properties of the endometrial and cervical adenocarcinoma. (2433372)
1986
49
Cervical adenocarcinoma in a woman on long-term contraceptives. (4817003)
1974
50
Brief recording. Cervical adenocarcinoma of mesonephric origin. (14438822)
1960

Genetic Variations for Cervical Adenocarcinoma

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Expression for genes affiliated with Cervical Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Adenocarcinoma

Search GEO for disease gene expression data for Cervical Adenocarcinoma.

Pathways for genes affiliated with Cervical Adenocarcinoma

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore
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Pathways related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CDKN1A
2
Hide members
10.4CDKN1B, CDKN1A, CDKN2A
310.4CDKN1B, CDKN1A, CDKN2A
410.4CDKN1B, CDKN1A, CDKN2A
5
Hide members
10.4CDKN2A, CDKN1A, CDKN1B
6
Hide members
10.4CDKN1B, CDKN1A, CDKN2A
710.4CDKN2A, CDKN1A, CDKN1B, RASSF1
8
Cell cycle Cell cycle (generic schema)
Hide members
10.4PGR, CDKN1B, CDKN1A, CDKN2A
9
Hide members
10.4CDKN1A, CDKN1B, PGR, CXCL12
1010.3CDKN2A, CDKN1A, CDKN1B, RASSF1, LAMC2
11
Hide members
10.3CDKN2A, CDH3, CDKN1A, CDKN1B, CXCL12, LAMC2

Compounds for genes affiliated with Cervical Adenocarcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CEACAM7, CALB2
2butyrate4410.8CDX2, CEACAM7, CALB2
3crcs4410.7CEACAM5, NME1, CDKN2A, RASSF1
4cycloheximide4410.7CXCL12, KRT8, CEACAM7
5mucicarmine4410.7CEACAM7, KRT7, KRT20, CEACAM5, CALB2
6gefitinib44 49 1112.7IFI27, CEACAM5, CDKN1B, CDKN1A, CEACAM7
7gold4410.7MUC16, KRT8, LAMC2, CEACAM5
8estradiol44 11 2412.7MUC16, PGR, CEACAM5
9adriamycin4410.7CEACAM5, CDKN2A, CDKN1A, PGR, KRT8
105-aza-2deoxycytidine4410.7CXCL12, RASSF1, CDKN2A, CDX2, CDKN1A, KRT7
11agar4410.7CEACAM5, KRT8, RASSF1, NME1, PGR, CDKN1A
12b 7234410.6CALB2, MUC16, KRT8, CEACAM5, CEACAM7, KRT20
13genistein44 28 59 2 11 2415.6IFI27, CDKN1B, KRT8, CXCL12, PGR, CDKN1A
14tamoxifen44 49 28 1113.6CXCL12, IFI27, CDKN1A, CDKN1B, PGR, KRT8
15retinoid4410.6CDKN1A, MUC5AC, IFI27, KRT8, PGR, KRT7
16resveratrol44 59 11 2413.6PGR
17ribonucleic acid4410.6CXCL12, PGR, MUC5AC, CEACAM5, KRT20, NME1
185fluorouracil4410.6CDKN2A, MUC5AC, PGR, CXCL12, NME1, CEACAM7
19actinomycin d4410.6CEACAM7, KRT8, CXCL12, CDKN1B, CDKN2A, CDKN1A
20dexamethasone44 49 28 1113.6MUC16, MUC5AC, CDKN2A, CXCL12, CDKN1B, IFI27
21n-acetylglucosamine4410.6KRT7, KRT8, MUC5AC, CEACAM5
22hyaluronic acid44 2411.6CEACAM5, KRT20, CALB2, CXCL12, MUC16
23hematoxylin4410.6KRT8, MUC16, CEACAM5, KRT20, MUC5AC, CDKN2A
24methotrexate44 49 1112.6CDKN1B, MUC5AC, CDKN2A, PGR, KRT7
25paclitaxel44 49 1112.6CALB2, IFI27, MUC16, CDKN2A, CDKN1A, CDKN1B
26steroid4410.6IFI27, MUC5AC, CDKN2A, CDX2, CXCL12, NME1
27oligonucleotide4410.6MUC5AC, IFI27, CDKN2A, CDX2, CDKN1A, CDKN1B
28lovastatin44 49 59 28 1114.6CDKN1B, CDKN1A, IFI27, CDKN2A
29thymidine44 2411.6CEACAM5, CALB2, IFI27, CDX2, CDKN1A, CXCL12
30cisplatin44 49 59 1113.6KRT8, RASSF1, NME1, CDKN1B, CDKN1A, CDKN2A
31doxorubicin44 49 1112.6CDKN2A, KRT8, KRT20, PGR, CDKN1B, CDKN1A
32n acetylcysteine4410.6CDKN1B, CDKN2A, IFI27, MUC5AC, CDKN1A
33p0034410.6CEACAM5, IFI27, RASSF1, CDKN1B
34threonine4410.6RASSF1, CXCL12, CDKN1B, CDKN1A, CDKN2A, MUC5AC
35cytarabine44 49 1112.6CDKN1B, CDKN1A, CDKN2A, IFI27
36eb 108944 5911.5CDKN1A, IFI27, CDKN1B
37retinoic acid44 2411.5NME1, KRT7, PGR, CEACAM7, CDKN1B, CDKN1A
38testosterone44 59 11 2413.5KRT20, KRT7, CDKN2A, PGR, CDKN1B, KRT8
39vegf4410.5MUC16, IFI27, CXCL12, CDKN2A, CDKN1A, CDKN1B
40calcium44 49 11 2413.5IFI27, MUC5AC, CALB2, CDH3, CDX2, NME1
41serine4410.5RASSF1, CDKN1A, CDKN1B, CDKN2A, CXCL12, KRT8
42sialic acid4410.5CEACAM5, KRT7
43troglitazone44 28 59 1113.5KRT20, CDKN1B, CDKN1A, IFI27
44tyrosine4410.4CDX2, CDKN1B, KRT20, CDKN1A, CALB2, KRT7
45p000484410.4CDKN1A, IFI27
46paraffin4410.4CALB2, IFI27, MUC16, CDKN2A, MUC5AC, CDH3
47progesterone44 59 28 11 2414.3CEACAM5, MUC5AC, MUC16, IFI27, CALB2, NME1
48optimax4410.3CDKN1A, IFI27
49cysteine4410.2CEACAM5, KRT8, MUC5AC, PGR, CDKN2A, CDX2
50pd 98,0594410.0MUC5AC, CXCL12, CDKN1B, CDKN1A, IFI27

GO Terms for genes affiliated with Cervical Adenocarcinoma

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16Gene Ontology
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Cellular components related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.4KRT8, KRT20, KRT7

Biological processes related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.6CDKN1B, CDKN1A, CDKN2A
2negative regulation of phosphorylationGO:04232610.5CDKN1B, CDKN1A, CDKN2A
3cell cycle arrestGO:00705010.5CDKN2A, CDKN1A, CDKN1B, RASSF1
4negative regulation of gene expressionGO:01062910.4NME1, PGR, CDKN1A
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.4CDKN1B, CDKN2A, IFI27
6cell adhesionGO:00715510.4MUC16, MUC5AC, CDH3, CXCL12, LAMC2
7Ras protein signal transductionGO:00726510.3CDKN2A, CDKN1A, RASSF1
8mitotic cell cycle arrestGO:07185010.1CDKN1B, CDKN1A

Molecular functions related to Cervical Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.4CDKN1B, CDKN1A, CDKN2A

Products for genes affiliated with Cervical Adenocarcinoma

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  • Antibodies
  • Proteins
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Sources for Cervical Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet