MCID: CRV035
MIFTS: 62

Cervical Cancer malady

Cancer diseases category

Summaries for Cervical Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. cervical cancer is caused by a virus called hpv. the virus spreads through sexual contact. most women's bodies are able to fight hpv infection. but sometimes the virus leads to cancer. you're at higher risk if you smoke, have many children, use birth control pills for a long time, or have hiv infection. cervical cancer may not cause any symptoms at first. later, you may have pelvic pain or bleeding from the vagina. it usually takes several years for normal cells in the cervix to turn into cancer cells. your health care provider can find abnormal cells by doing a pap test - examining cells from the cervix under a microscope. if there are abnormal cells, you will need a biopsy. by getting regular pap tests and pelvic exams you can find and treat any problems before they turn into cancer. treatment may include surgery, radiation therapy, chemotherapy, or a combination. the choice of treatment depends on the size of the tumor, whether the cancer has spread and whether you would like to become pregnant someday. vaccines can protect against several types of hpv, including some that can cause cancer. nih: national cancer institute

MalaCards: Cervical Cancer, also known as cervical carcinoma, is related to cervical intraepithelial neoplasia and thyroid cancer. An important gene associated with Cervical Cancer is ST3 (suppression of tumorigenicity 3), and among its related pathways are Pathways in cancer and VEGFR3 signaling in lymphatic endothelium. Affiliated tissues include the cervix uteri or, cervix and lymph node.

Disease Ontology:8 A cervix uteri cancer that is located in the cervix uteri or located in the cervical area.

CDC:3 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

Wikipedia:63 Cervical cancer is a malignant neoplasm arising from cells originating in the cervix uteri. One of the... more...

Description from OMIM:46 603956

Aliases & Classifications for Cervical Cancer

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 46OMIM, 22GTR, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical cancer 8 10 44 33
cervical carcinoma 8 46 44
carcinoma of cervix 8 22
cervix carcinoma 8 60
carcinoma of the cervix uteri 8
neoplasm of uterine cervix 8
uterine cervical neoplasm 60
tumor of the cervix uteri 8
carcinoma cervix uteri 8
malignant neoplasms 60
cervix uteri cancer 8
cervical neoplasm 8
cancer of cervix 8
cervix cancer 8


Related Diseases for Cervical Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cervical Cancer family:

Cervical Benign Neoplasm

Diseases related to Cervical Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 753)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia30.0VEGFC
2thyroid cancer29.8VEGFC, FGFR3, PIK3CA
3cervicitis11.5
4lymph node cancer10.7
5tongue cancer10.6
6nasopharynx carcinoma10.6
7breast cancer10.6
8cervical squamous cell carcinoma10.6
9squamous cell carcinoma10.6
10lip cancer10.6
11papilloma10.6
12vascular cancer10.6
13hypopharynx cancer10.5
14pancreatic cancer10.5
15oropharynx cancer10.5
16oral cavity cancer10.5
17adenoid cystic carcinoma10.4
18cervical adenoid cystic carcinoma10.4
19adenoiditis10.4
20rare squamous cell carcinoma of the cervix uteri10.4
21glassy cell carcinoma of the cervix uteri10.4
22adenoid basal carcinoma of the cervix uteri10.4
23papillary carcinoma of the cervix uteri10.4
24primitive neuroectodermal tumor10.4
25malignant müllerian mixed tumor of the cervix uteri10.4
26malignant peripheral neuroectodermal tumor of the cervix uteri10.4
27malignant germ cell tumor of the cervix uteri10.4
28vaginal cancer10.4
29vaginitis10.4
30cell type cancer10.4
31ovarian cancer10.4
32salivary gland cancer10.4
33male germ cell tumor, somatic10.4
34parathyroid carcinoma10.3
35epiglottis neoplasm10.3
36splenic flexure cancer10.3
37childhood leukemia10.3
38adenocarcinoma10.3
39cervical adenocarcinoma10.3
40spinal meninges cancer10.3
41pancreatic ductal carcinoma10.3
42langerhans-cell histiocytosis10.3
43male reproductive organ cancer10.3
44cystic basal cell carcinoma10.3
45adenoid squamous cell carcinoma10.3
46adenoid basal cell carcinoma10.3
47cervical clear cell adenocarcinoma10.3
48verrucous carcinoma10.3
49cheek mucosa cancer10.3
50tonsillar fossa cancer10.3

Graphical network of the top 20 diseases related to Cervical Cancer:



Diseases related to cervical cancer

Clinical Features for Cervical Cancer

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46OMIM
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Clinical features from OMIM:

603956

Drugs & Therapeutics for Cervical Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Cancer

Drug clinical trials:

Search ClinicalTrials for Cervical Cancer

Search NIH Clinical Center for Cervical Cancer

Search CenterWatch for Cervical Cancer

Genetic Tests for Cervical Cancer

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Sources:
22GTR
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Genetic tests related to Cervical Cancer:

id Genetic test Affiliating Genes
1 Carcinoma of Cervix22

Anatomical Context for Cervical Cancer

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Cervical Cancer:

32
Cervix, Lymph node, Testes, Breast, Uterus, Endothelial, Thyroid, T cells, Tongue, Lung, Bone, Liver, Colon, Prostate, Nk cells, Monocytes, Myeloid, Tonsil, Testis, Ovary, Skin, Salivary gland, Small intestine, Bone marrow

FMA organs/tissues related to Cervical Cancer:

14
The cervix uteri or

Animal Models for Cervical Cancer or affiliated genes

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Publications for Cervical Cancer

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50PubMed
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Articles related to Cervical Cancer:

(show top 50)    (show all 2052)
idTitleAuthorsYear
1
Human papillomavirus 33 worldwide genetic variation and associated risk of cervical cancer. (24314666)
2014
2
Women whose cervical intraepithelial neoplasia has been treated or resolved remain at continued high risk for cervical cancer. (23378629)
2013
3
HPV16 E5 peptide vaccine in treatment of cervical cancer in vitro and in vivo. (24142729)
2013
4
Community health workers, social support and cervical cancer screening among high-risk groups in rural Mexico. (24185143)
2013
5
Voxelwise comparison of perfusion parameters estimated using dynamic contrast enhanced (DCE) computed tomography and DCE-magnetic resonance imaging in locally advanced cervical cancer. (24003852)
2013
6
High-risk clinical target volume delineation in CT-guided cervical cancer brachytherapy: impact of information from FIGO stage with or without systematic inclusion of 3D documentation of clinical gynecological examination. (23905674)
2013
7
Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells. (24214831)
2013
8
Anticancer effects of the engineered stem cells transduced with therapeutic genes via a selective tumor tropism caused by vascular endothelial growth factor toward HeLa cervical cancer cells. (24008363)
2013
9
The Clinical Role of HPV Testing in Primary and Secondary Cervical Cancer Screening. (23935630)
2013
10
The Peru Cervical Cancer Screening Study (PERCAPS): The Design and Implementation of a Mother/Daughter Screen, Treat, and Vaccinate Program in the Peruvian Jungle. (24276617)
2013
11
Radiological image-guided placement of covered Niti-S stent for palliation of dysphagia in patients with cervical esophageal cancer. (23370813)
2013
12
Matrix metalloproteinase-9 is a prognostic marker for patients with cervical cancer. (22752570)
2012
13
The TPX2 gene is a promising diagnostic and therapeutic target for cervical cancer. (22307108)
2012
14
Methylenetetrahydrofolate reductase C677T polymorphism and cervical cancer risk: a meta-analysis. (22901193)
2012
15
Analysis of TNFI+ promoter SNPs and the risk of cervical cancer in urban populations of Posadas (Misiones, Argentina). (22019249)
2012
16
The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer. (22472886)
2012
17
MAML1 regulates cell viability via the NF-I_B pathway in cervical cancer cell lines. (21640102)
2011
18
Identification and analysis of novel microRNAs from fragile sites of human cervical cancer: computational and experimental approach. (21377523)
2011
19
Role of CD4 and CD8 T-lymphocytes, B-lymphocytes and Natural Killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients. (21142701)
2011
20
Expression and clinical implications of homeobox gene Six1 in cervical cancer cell lines and cervical epithelial tissues. (21370601)
2010
21
A response to Ms Sandercock and Dr Burls regarding the methods used in the analysis for our first paper 'Natural history of cervical neoplasia and risk of invasive cancer in women diagnosed with cervical intraepithelial neoplasia 3'. (20927168)
2010
22
Overexpression of Bmi-1 in uterine cervical cancer: correlation with clinicopathology and prognosis. (21370603)
2010
23
VEGF polymorphisms in early cervical cancer susceptibility, angiogenesis, and survival. (20797778)
2010
24
Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk. (20069434)
2010
25
Sex steroid hormones influence the risk for cervical cancer: modulation by haptoglobin genetic polymorphism. (19446743)
2009
26
Transition of cervical carcinoma in situ to invasive cancer: role of p16 INK4a expression in progression and in recurrence. (19100258)
2009
27
Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein. (18714566)
2008
28
Protease-activated receptor-2 (PAR-2) in cervical cancer proliferation. (17936340)
2008
29
Some but not all of HLA-II alleles are associated with cervical cancer in Chinese women. (19027490)
2008
30
Human leukocyte antigen class II alleles and risk of cervical cancer in China. (17349874)
2007
31
Overexpression of epidermal growth factor type-1 receptor (EGF-R1) in cervical cancer: implications for Cetuximab-mediated therapy in recurrent/metastatic disease. (17540437)
2007
32
Notch1 induces cell cycle arrest and apoptosis in human cervical cancer cells: involvement of nuclear factor kappa B inhibition. (17316355)
2007
33
Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone. (16527337)
2006
34
Tumor-associated carbonic anhydrases are linked to metastases in primary cervical cancer. (16416108)
2006
35
Activation of p53 in cervical cancer cells by human papillomavirus E6 RNA interference is transient, but can be sustained by inhibiting endogenous nuclear export-dependent p53 antagonists. (17178878)
2006
36
Chemotherapy compounds in cervical cancer cells primed by reconstitution of p53 function after short interfering RNA-mediated degradation of human papillomavirus 18 E6 mRNA: opposite effect of siRNA in combination with different drugs. (15908516)
2005
37
Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53. (15790450)
2005
38
Potentiation of the radiation effect with genistein in cervical cancer cells. (16083949)
2005
39
Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer. (15073118)
2004
40
Expression of p27, p21, and p16 protein in early squamous cervical cancer and its relation to prognosis. (12694668)
2003
41
Oxidative stress and tumor markers in cervical cancer patients. (14972792)
2002
42
Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer. (12413893)
2002
43
Loss of Fhit expression as a potential marker of malignant progression in preinvasive squamous cervical cancer. (12144820)
2002
44
IFNalpha sensitizes ME-180 human cervical cancer cells to TNFalpha-induced apoptosis by inhibiting cytoprotective NF-kappaB activation. (11322949)
2001
45
Growth inhibition of cervical cancer cells by the human retinoic acid receptor beta gene. (10629091)
2000
46
Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer. (9683295)
1998
47
Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. (9537264)
1998
48
Cytokeratin-19 associated with apoptosis and chemosensitivity in human cervical cancer cells. (14646570)
1997
49
Augmenting effect of sizofiran on the immunofunction of regional lymph nodes in cervical cancer. (1739919)
1992
50
Occurrence of malignant peritoneal mesothelioma after surgery and irradiation for cervical cancer. (6706236)
1984

Genetic Variations for Cervical Cancer

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Expression for genes affiliated with Cervical Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Cancer

Search GEO for disease gene expression data for Cervical Cancer.

Pathways for genes affiliated with Cervical Cancer

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Cervical Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2WNT6, FGFR3, VEGFC, PIK3CA
210.8VEGFC, PIK3CA

Compounds for genes affiliated with Cervical Cancer

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GO Terms for genes affiliated with Cervical Cancer

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16Gene Ontology
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Biological processes related to Cervical Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:00150111.0PAX1, FGFR3, HEXB
2bone morphogenesisGO:06034910.5PAX1, FGFR3

Products for genes affiliated with Cervical Cancer

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Sources for Cervical Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet