MCID: CRV035
MIFTS: 62

Cervical Cancer malady

Cancer diseases category

Summaries for Cervical Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. cervical cancer is caused by a virus called hpv. the virus spreads through sexual contact. most women's bodies are able to fight hpv infection. but sometimes the virus leads to cancer. you're at higher risk if you smoke, have many children, use birth control pills for a long time, or have hiv infection. cervical cancer may not cause any symptoms at first. later, you may have pelvic pain or bleeding from the vagina. it usually takes several years for normal cells in the cervix to turn into cancer cells. your health care provider can find abnormal cells by doing a pap test - examining cells from the cervix under a microscope. if there are abnormal cells, you will need a biopsy. by getting regular pap tests and pelvic exams you can find and treat any problems before they turn into cancer. treatment may include surgery, radiation therapy, chemotherapy, or a combination. the choice of treatment depends on the size of the tumor, whether the cancer has spread and whether you would like to become pregnant someday. vaccines can protect against several types of hpv, including some that can cause cancer. nih: national cancer institute

MalaCards: Cervical Cancer, also known as cervical carcinoma, is related to cervical intraepithelial neoplasia and thyroid cancer. An important gene associated with Cervical Cancer is ST3 (suppression of tumorigenicity 3), and among its related pathways are Pathways in cancer and VEGFR3 signaling in lymphatic endothelium. Affiliated tissues include the cervix uteri or, cervix and lymph node.

Disease Ontology:8 A cervix uteri cancer that is located in the cervix uteri or located in the cervical area.

CDC:3 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

Wikipedia:63 Cervical cancer is a malignant neoplasm arising from cells originating in the cervix uteri. One of the... more...

Description from OMIM:46 603956

Aliases & Classifications for Cervical Cancer

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Sources:
8Disease Ontology, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical cancer 8 10 44 33
cervical carcinoma 8 46 44
carcinoma of cervix 8 22
cervix carcinoma 8 60
carcinoma of the cervix uteri 8
neoplasm of uterine cervix 8
uterine cervical neoplasm 60
tumor of the cervix uteri 8
carcinoma cervix uteri 8
malignant neoplasms 60
cervix uteri cancer 8
cervical neoplasm 8
cancer of cervix 8
cervix cancer 8


Related Diseases for Cervical Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cervical Cancer family:

Cervical Benign Neoplasm

Diseases related to Cervical Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 753)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia30.0VEGFC
2thyroid cancer29.8VEGFC, FGFR3, PIK3CA
3cervicitis11.5
4lymph node cancer10.7
5tongue cancer10.6
6nasopharynx carcinoma10.6
7breast cancer10.6
8cervical squamous cell carcinoma10.6
9squamous cell carcinoma10.6
10lip cancer10.6
11papilloma10.6
12vascular cancer10.6
13hypopharynx cancer10.5
14pancreatic cancer10.5
15oropharynx cancer10.5
16oral cavity cancer10.5
17adenoid cystic carcinoma10.4
18cervical adenoid cystic carcinoma10.4
19adenoiditis10.4
20rare squamous cell carcinoma of the cervix uteri10.4
21glassy cell carcinoma of the cervix uteri10.4
22adenoid basal carcinoma of the cervix uteri10.4
23papillary carcinoma of the cervix uteri10.4
24primitive neuroectodermal tumor10.4
25malignant müllerian mixed tumor of the cervix uteri10.4
26malignant peripheral neuroectodermal tumor of the cervix uteri10.4
27malignant germ cell tumor of the cervix uteri10.4
28vaginal cancer10.4
29vaginitis10.4
30cell type cancer10.4
31ovarian cancer10.4
32salivary gland cancer10.4
33male germ cell tumor, somatic10.4
34parathyroid carcinoma10.3
35epiglottis neoplasm10.3
36splenic flexure cancer10.3
37childhood leukemia10.3
38adenocarcinoma10.3
39cervical adenocarcinoma10.3
40spinal meninges cancer10.3
41pancreatic ductal carcinoma10.3
42langerhans-cell histiocytosis10.3
43male reproductive organ cancer10.3
44cystic basal cell carcinoma10.3
45adenoid squamous cell carcinoma10.3
46adenoid basal cell carcinoma10.3
47cervical clear cell adenocarcinoma10.3
48verrucous carcinoma10.3
49cheek mucosa cancer10.3
50tonsillar fossa cancer10.3

Graphical network of the top 20 diseases related to Cervical Cancer:



Diseases related to cervical cancer

Clinical Features for Cervical Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

603956

Drugs & Therapeutics for Cervical Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Cancer

Drug clinical trials:

Search ClinicalTrials for Cervical Cancer

Search NIH Clinical Center for Cervical Cancer

Search CenterWatch for Cervical Cancer

Genetic Tests for Cervical Cancer

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Sources:
22GTR
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Genetic tests related to Cervical Cancer:

id Genetic test Affiliating Genes
1 Carcinoma of Cervix22

Anatomical Context for Cervical Cancer

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Cervical Cancer:

32
Cervix, Lymph node, Testes, Breast, Uterus, Endothelial, Thyroid, T cells, Tongue, Lung, Bone, Liver, Colon, Prostate, Nk cells, Monocytes, Myeloid, Tonsil, Testis, Ovary, Skin, Salivary gland, Small intestine, Bone marrow

FMA organs/tissues related to Cervical Cancer:

14
The cervix uteri or

Animal Models for Cervical Cancer or affiliated genes

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Publications for Cervical Cancer

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Sources:
50PubMed
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Articles related to Cervical Cancer:

(show top 50)    (show all 2052)
idTitleAuthorsYear
1
Cervical Cancer Rates After the Transition From Annual Pap to 3-Year HPV and Pap. (24022057)
2014
2
Lead time and down-staging in the survival of cervical cancer cases detected by screening. (23954186)
2013
3
Image-guided brachytherapy for cervical cancer: Analysis of D2 cc hot spot in three-dimensional and anatomic factors affecting D2 cc hot spot inA organs at risk. (23953809)
2013
4
Reply: 'Comment on Phase III randomised controlled trial of neoadjuvant chemotherapy plus radical surgery vs radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102)'. (24064978)
2013
5
Cervical cancer and the global health agenda: Insights from multiple policy-analysis frameworks. (24236409)
2013
6
Appalachian women's perspectives on breast and cervical cancer screening. (24016336)
2013
7
Ubiquitin-specific protease 22: a novel molecular biomarker in cervical cancer prognosis and therapeutics. (23979981)
2013
8
Human Papillomavirus Prevalence and Type-Distribution, Cervical Cancer Screening Practices and Current Status of Vaccination Implementation in Russian Federation, the Western Countries of the former Soviet Union, Caucasus Region and Central Asia. (24332297)
2013
9
XRCC1 polymorphisms and cervical cancer risk: an updated meta-analysis. (24057881)
2013
10
Analysis of factors contributing to the low survival of cervical cancer patients undergoing radiotherapy in Kenya. (24205226)
2013
11
Correlation between FDG uptake by PET/CT and the expressions of glucose transporter type 1 and hexokinase II in cervical cancer. (22398711)
2012
12
Fluorescence spectroscopy: a new approach in cervical cancer. (23904705)
2012
13
Screening test results associated with cancer diagnoses in 287 women with cervical squamous cell carcinoma. (22900617)
2012
14
CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients. (22531719)
2012
15
Beclin 1 influences cisplatin-induced apoptosis in cervical cancer CaSki cells by mitochondrial dependent pathway. (22805532)
2012
16
Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy. (21330833)
2011
17
Polymorphism in exon 4 of TP53 gene associated to HPV 16 and 18 in Mexican women with cervical cancer. (20661667)
2011
18
The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism. (21911617)
2011
19
Human papillomavirus infection in Honduran women with cervical intraepithelial neoplasia or cervical cancer. (21192177)
2011
20
Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome. (21040567)
2010
21
Oncosuppressor proteins of fragile sites are reduced in cervical cancer. (19700237)
2010
22
Cervical manifestation of a borderline type ovarian cancer with pseudomyxoma peritonei - a case report. (20683044)
2010
23
Association of TP53 codon 72 polymorphism with cervical cancer risk in Chinese women. (20193851)
2010
24
Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment. (19180585)
2009
25
MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells. (19859982)
2009
26
Discrepancies in expression and prognostic value of tumor markers in adenocarcinoma and squamous cell carcinoma in cervical cancer. (19596931)
2009
27
Effects of 5-aminolevulinic acid photodynamic therapy on cervical cancer: in vivo experiment with nude mice]. (18646722)
2008
28
Effect of fluidizing agents on paclitaxel penetration in cervical cancerous monolayer membranes. (17712507)
2007
29
Lack of association between -460 C/T and 936 C/T of the vascular endothelial growth factor and angiopoietin-2 exon 4 G/A polymorphisms and ovarian, cervical, and endometrial cancers. (17630849)
2007
30
Clinical implications of osteopontin in metastatic lesions of uterine cervical cancers. (16675104)
2007
31
Endothelin-3 growth factor levels decreased in cervical cancer compared with normal cervical epithelial cells. (17445867)
2007
32
Expression of Eph B4 and Ephrin B2 in cervical cancer tissues and angiogenesis. (17196593)
2007
33
Therapeutic potential of an adenovirus expressing p73 beta, a p53 homologue, against human papilloma virus positive cervical cancer in vitro and in vivo. (16481734)
2006
34
Cytotoxicity of docetaxel (Taxotere) used as a single agent and in combination with radiation in human gastric, cervical and pancreatic cancer cells. (16899972)
2006
35
Chapter 10: New dimensions in cervical cancer screening. (16950022)
2006
36
Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma. (16331610)
2006
37
Expression of survivin, cyclinD1, p21(WAF1), caspase-3 in cervical cancer and its relation with prognosis. (15934315)
2005
38
Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells. (15264212)
2004
39
Clinical implication of expression of vascular endothelial growth factor-C in metastatic lymph nodes of uterine cervical cancers. (15226772)
2004
40
Cyclooxygenase-2 (COX-2) expression in locally advanced cervical cancer patients undergoing chemoradiation plus surgery. (12504032)
2003
41
Abnormal fragile histidine triad expression in advanced cervical cancer and evaluation of its utility as a prognostic factor. (12837987)
2003
42
Analysis of 174 cases with cervical cancer in women under 35 years old]. (14728859)
2003
43
The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review. (12657108)
2003
44
Effects of anti-HPV16 E6-ribozyme on the proliferation and apoptosis of human cervical cancer cell line CaSKi. (12297466)
2002
45
Circulating lipid peroxidation and antioxidant status in cervical cancer patients: a case-control study. (12498996)
2002
46
Cyclooxygenase-2 is overexpressed in human cervical cancer. (11234900)
2001
47
Expression of truncated FHIT transcripts in cervical cancers and in normal human cells. (11498789)
2001
48
p53 codon 72 polymorphism and risk of cervical cancer in UK. (9742979)
1998
49
Bax and Bcl-2 expressions predict response to radiotherapy in human cervical cancer. (9808425)
1998
50
Prognostic value of CD44 splice variants in human stage III cervical cancer. (7488429)
1995

Genetic Variations for Cervical Cancer

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Expression for genes affiliated with Cervical Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Cancer

Search GEO for disease gene expression data for Cervical Cancer.

Pathways for genes affiliated with Cervical Cancer

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Cervical Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2WNT6, FGFR3, VEGFC, PIK3CA
210.8VEGFC, PIK3CA

Compounds for genes affiliated with Cervical Cancer

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GO Terms for genes affiliated with Cervical Cancer

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16Gene Ontology
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Biological processes related to Cervical Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:00150111.0PAX1, FGFR3, HEXB
2bone morphogenesisGO:06034910.5PAX1, FGFR3

Products for genes affiliated with Cervical Cancer

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Sources for Cervical Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet