MCID: CRV035
MIFTS: 62

Cervical Cancer malady

Cancer diseases category

Summaries for Cervical Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. cervical cancer is caused by a virus called hpv. the virus spreads through sexual contact. most women's bodies are able to fight hpv infection. but sometimes the virus leads to cancer. you're at higher risk if you smoke, have many children, use birth control pills for a long time, or have hiv infection. cervical cancer may not cause any symptoms at first. later, you may have pelvic pain or bleeding from the vagina. it usually takes several years for normal cells in the cervix to turn into cancer cells. your health care provider can find abnormal cells by doing a pap test - examining cells from the cervix under a microscope. if there are abnormal cells, you will need a biopsy. by getting regular pap tests and pelvic exams you can find and treat any problems before they turn into cancer. treatment may include surgery, radiation therapy, chemotherapy, or a combination. the choice of treatment depends on the size of the tumor, whether the cancer has spread and whether you would like to become pregnant someday. vaccines can protect against several types of hpv, including some that can cause cancer. nih: national cancer institute

MalaCards: Cervical Cancer, also known as cervical carcinoma, is related to cervical intraepithelial neoplasia and thyroid cancer. An important gene associated with Cervical Cancer is ST3 (suppression of tumorigenicity 3), and among its related pathways are Pathways in cancer and VEGFR3 signaling in lymphatic endothelium. Affiliated tissues include the cervix uteri or, cervix and lymph node.

Disease Ontology:8 A cervix uteri cancer that is located in the cervix uteri or located in the cervical area.

CDC:3 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

Wikipedia:63 Cervical cancer is a malignant neoplasm arising from cells originating in the cervix uteri. One of the... more...

Description from OMIM:46 603956

Aliases & Classifications for Cervical Cancer

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Sources:
8Disease Ontology, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical cancer 8 10 44 33
cervical carcinoma 8 46 44
carcinoma of cervix 8 22
cervix carcinoma 8 60
carcinoma of the cervix uteri 8
neoplasm of uterine cervix 8
uterine cervical neoplasm 60
tumor of the cervix uteri 8
carcinoma cervix uteri 8
malignant neoplasms 60
cervix uteri cancer 8
cervical neoplasm 8
cancer of cervix 8
cervix cancer 8


Related Diseases for Cervical Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cervical Cancer family:

Cervical Benign Neoplasm

Diseases related to Cervical Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 753)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia30.0VEGFC
2thyroid cancer29.8VEGFC, FGFR3, PIK3CA
3cervicitis11.5
4lymph node cancer10.7
5tongue cancer10.6
6nasopharynx carcinoma10.6
7breast cancer10.6
8cervical squamous cell carcinoma10.6
9squamous cell carcinoma10.6
10lip cancer10.6
11papilloma10.6
12vascular cancer10.6
13hypopharynx cancer10.5
14pancreatic cancer10.5
15oropharynx cancer10.5
16oral cavity cancer10.5
17adenoid cystic carcinoma10.4
18cervical adenoid cystic carcinoma10.4
19adenoiditis10.4
20rare squamous cell carcinoma of the cervix uteri10.4
21glassy cell carcinoma of the cervix uteri10.4
22adenoid basal carcinoma of the cervix uteri10.4
23papillary carcinoma of the cervix uteri10.4
24primitive neuroectodermal tumor10.4
25malignant müllerian mixed tumor of the cervix uteri10.4
26malignant peripheral neuroectodermal tumor of the cervix uteri10.4
27malignant germ cell tumor of the cervix uteri10.4
28vaginal cancer10.4
29vaginitis10.4
30cell type cancer10.4
31ovarian cancer10.4
32salivary gland cancer10.4
33male germ cell tumor, somatic10.4
34parathyroid carcinoma10.3
35epiglottis neoplasm10.3
36splenic flexure cancer10.3
37childhood leukemia10.3
38adenocarcinoma10.3
39cervical adenocarcinoma10.3
40spinal meninges cancer10.3
41pancreatic ductal carcinoma10.3
42langerhans-cell histiocytosis10.3
43male reproductive organ cancer10.3
44cystic basal cell carcinoma10.3
45adenoid squamous cell carcinoma10.3
46adenoid basal cell carcinoma10.3
47cervical clear cell adenocarcinoma10.3
48verrucous carcinoma10.3
49cheek mucosa cancer10.3
50tonsillar fossa cancer10.3

Graphical network of the top 20 diseases related to Cervical Cancer:



Diseases related to cervical cancer

Clinical Features for Cervical Cancer

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46OMIM
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Clinical features from OMIM:

603956

Drugs & Therapeutics for Cervical Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Cancer

Drug clinical trials:

Search ClinicalTrials for Cervical Cancer

Search NIH Clinical Center for Cervical Cancer

Search CenterWatch for Cervical Cancer

Genetic Tests for Cervical Cancer

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Sources:
22GTR
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Genetic tests related to Cervical Cancer:

id Genetic test Affiliating Genes
1 Carcinoma of Cervix22

Anatomical Context for Cervical Cancer

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Cervical Cancer:

32
Cervix, Lymph node, Testes, Breast, Uterus, Endothelial, Thyroid, T cells, Tongue, Lung, Bone, Liver, Colon, Prostate, Nk cells, Monocytes, Myeloid, Tonsil, Testis, Ovary, Skin, Salivary gland, Small intestine, Bone marrow

FMA organs/tissues related to Cervical Cancer:

14
The cervix uteri or

Animal Models for Cervical Cancer or affiliated genes

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Publications for Cervical Cancer

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50PubMed
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Articles related to Cervical Cancer:

(show top 50)    (show all 2052)
idTitleAuthorsYear
1
Pushing the bar in treatment of cervical cancer: what can comprehensive cancer centers do on their own? (23938373)
2013
2
Validation of the European Organization for Research and Treatment of Cancer cervical cancer module for Chinese patients with cervical cancer. (24204125)
2013
3
Cost-utility analysis of interventions to reduce the burden of cervical cancer in Israel. (24229719)
2013
4
Recurrent cervical cancer isolated to the sigmoid colon: A case report. (24371713)
2013
5
Gliotoxin Isolated from Marine Fungus Aspergillus sp. Induces Apoptosis of Human Cervical Cancer and Chondrosarcoma Cells. (24368570)
2013
6
High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone. (23904154)
2013
7
Non-steroidal anti-inflammatory drug use and cervical cancer risk: a case-control study using the Clinical Practice Research Datalink. (24042024)
2013
8
Understanding cervical cancer screening intentions among Latinas using an expanded theory of planned behavior model. (23930898)
2013
9
Better survival with three-dimensional conformal radiotherapy than with conventional radiotherapy for cervical cancer: a population-based study. (24224099)
2013
10
Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer. (22330137)
2013
11
The path to eliminate cervical cancer in the world and the challenges of professional education. (24332302)
2013
12
From Papanicolaou to papillomaviruses: evolving challenges in cervical cancer screening in the era of human papillomavirus vaccination. (24096622)
2013
13
Self-collecting a cervico-vaginal specimen for cervical cancer screening: An exploratory study of acceptability among medically underserved women in rural Appalachia. (24125753)
2013
14
Interleukin 10 polymorphisms and cervical cancer risk: a meta-analysis. (23095823)
2013
15
Clinical implication of elevated human cervical cancer oncogene-1 expression in esophageal squamous cell carcinoma. (22511601)
2012
16
Overexpression of BMI-1 is associated with poor prognosis in cervical cancer. (22898137)
2012
17
Metastatic breast cancer to the uterine cervix mimicking a giant cervical leiomyoma. (23092107)
2012
18
FOXM1 promotes tumor cell invasion and correlates with poor prognosis in early-stage cervical cancer. (22943878)
2012
19
Omission of excisional therapy is associated with an increased risk of invasive cervical cancer after cervical intraepithelial neoplasia III. (21658934)
2012
20
Population-based prevalence of abnormal cervical cytology findings and local risk factors in Ibadan, Nigeria: implications for cervical cancer control programs and human papilloma virus immunization. (22555526)
2012
21
Human papillomavirus's physical state and cyclin A1 promoter methylation in cervical cancer. (21412159)
2011
22
Is there a biological plausability for p53 codon 72 polymorphism influence on cervical cancer development? (21672450)
2011
23
Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. (21876174)
2011
24
Down-regulation of HPV18 E6, E7, or VEGF expression attenuates malignant biological behavior of human cervical cancer cells. (21222176)
2011
25
Prospective study of the association of serum gamma-glutamyltransferase with cervical intraepithelial neoplasia III and invasive cervical cancer. (20388786)
2010
26
Correlation between the presence of high-risk human papillomaviruses and Id gene expression in Syrian women with cervical cancer. (19438642)
2010
27
Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial. (19232434)
2009
28
Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women. (19272325)
2009
29
CDH1 polymorphism and its association with the risk of cervical cancer]. (19563064)
2009
30
A case-control study on the association of RFC-1 polymorphism and cervical cancer]. (19565885)
2009
31
Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning. (18381458)
2008
32
Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population. (18608185)
2008
33
Prognostic significance of HIF-2alpha expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy. (18319549)
2008
34
p53 Loss synergizes with estrogen and papillomaviral oncogenes to induce cervical and breast cancers. (18413729)
2008
35
Prognostic impact of HIF-1alpha expression in patients with definitive radiotherapy for cervical cancer. (18330514)
2008
36
Uncoupling of promoter methylation and expression of Period1 in cervical cancer cells. (17592726)
2007
37
Immunoreactivities of human nonmetastatic clone 23 and p53 products are disassociated and not good predictors of lymph node metastases in early-stage cervical cancer patients. (17375700)
2007
38
Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03. (17767549)
2007
39
Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. (17343570)
2007
40
Loss of MSH2 protein expression is a risk factor in early stage cervical cancer. (17596548)
2007
41
DNA methylation profile at the DNMT3L promoter: a potential biomarker for cervical cancer. (17965599)
2007
42
Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression. (16803520)
2006
43
Hypoxia and expression of the proapoptotic regulator BNIP3 in cervical cancer. (16803523)
2006
44
Upregulation of telomerase (hTERT) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus, virus persistence, or disease outcome in cervical cancer. (17041957)
2006
45
Correlation between p14(ARF)/p16(INK4A) expression and HPV infection in uterine cervical cancer. (15312681)
2004
46
Acquired and genetic susceptibility to cervical cancer. (14644338)
2003
47
Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer. (12894231)
2003
48
Involvement of PKC-alpha in regulatory volume decrease responses and activation of volume-sensitive chloride channels in human cervical cancer HT-3 cells. (9763633)
1998
49
Brachytherapy in the presence of pyuria after pelvic irradiation for cervical cancer. (9744724)
1998
50
A quantitative approach to the loss of heterozygosity in p53 allele on detection of human cervical cancer using a BioImaging Analyzer. (8172533)
1994

Genetic Variations for Cervical Cancer

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Expression for genes affiliated with Cervical Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Cancer

Search GEO for disease gene expression data for Cervical Cancer.

Pathways for genes affiliated with Cervical Cancer

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Cervical Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2WNT6, FGFR3, VEGFC, PIK3CA
210.8VEGFC, PIK3CA

Compounds for genes affiliated with Cervical Cancer

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GO Terms for genes affiliated with Cervical Cancer

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16Gene Ontology
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Biological processes related to Cervical Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:00150111.0PAX1, FGFR3, HEXB
2bone morphogenesisGO:06034910.5PAX1, FGFR3

Products for genes affiliated with Cervical Cancer

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  • Antibodies
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  • Antibodies

Sources for Cervical Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet