MCID: CRV035
MIFTS: 60

Cervical Cancer malady

Cancer diseases category

Summaries for Cervical Cancer

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. cervical cancer is caused by a virus called hpv. the virus spreads through sexual contact. most women's bodies are able to fight hpv infection. but sometimes the virus leads to cancer. you're at higher risk if you smoke, have many children, use birth control pills for a long time, or have hiv infection. cervical cancer may not cause any symptoms at first. later, you may have pelvic pain or bleeding from the vagina. it usually takes several years for normal cells in the cervix to turn into cancer cells. your health care provider can find abnormal cells by doing a pap test - examining cells from the cervix under a microscope. if there are abnormal cells, you will need a biopsy. by getting regular pap tests and pelvic exams you can find and treat any problems before they turn into cancer. treatment may include surgery, radiation therapy, chemotherapy, or a combination. the choice of treatment depends on the size of the tumor, whether the cancer has spread and whether you would like to become pregnant someday. vaccines can protect against several types of hpv, including some that can cause cancer. nih: national cancer institute

MalaCards: Cervical Cancer, also known as cervical carcinoma, is related to oral cancer and stomach cancer. An important gene associated with Cervical Cancer is ST3 (suppression of tumorigenicity 3), and among its related pathways are Angiogenesis and Pathways in cancer. The compounds glyceraldehyde 3-phosphate and paraffin have been mentioned in the context of this disorder. Affiliated tissues include the cervix uteri or, cervix and testes.

Disease Ontology:9 A cervix uteri cancer that is located in the cervix uteri or located in the cervical area.

CDC:4 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

Wikipedia:66 Cervical cancer is a cancer arising from the cervix. It is due to the abnormal growth of cells that have... more...

Description from OMIM:48 603956

Aliases & Classifications for Cervical Cancer

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Sources:
9Disease Ontology, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical cancer 9 11 46 35
cervical carcinoma 9 48 46
cervix carcinoma 9 63
cancer of cervix 9 23
carcinoma of the cervix uteri 9
neoplasm of uterine cervix 9
uterine cervical neoplasm 63
tumor of the cervix uteri 9
carcinoma cervix uteri 9
carcinoma of cervix 9
cervix uteri cancer 9
malignant neoplasms 63
cervical neoplasm 9
cervix cancer 9


Related Diseases for Cervical Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Cervical Cancer family:

Cervical Benign Neoplasm

Diseases related to Cervical Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer29.9CD82, HIF1A, VEGFC
2stomach cancer29.8FGFR3, CD82, HIF1A, VEGFC
3melanoma29.8VEGFC, HIF1A, MCM3, CD82, FGFR3
4prostate cancer29.8VEGFC, HIF1A, EEF1A1, CD82, FGFR3
5cervicitis11.5
6cervical intraepithelial neoplasia10.8
7endotheliitis10.6
8papilloma10.6
9hypoxia10.5
10cervical adenoid cystic carcinoma10.5
11rare squamous cell carcinoma of the cervix uteri10.5
12poorly differentiated endocrine carcinoma of the cervix uteri10.5
13glassy cell carcinoma of the cervix uteri10.5
14adenoid basal carcinoma of the cervix uteri10.5
15papillary carcinoma of the cervix uteri10.5
16primitive neuroectodermal tumor10.5
17malignant mĆ¼llerian mixed tumor of the cervix uteri10.5
18malignant peripheral neuroectodermal tumor of the cervix uteri10.5
19malignant germ cell tumor of the cervix uteri10.5
20vaginitis10.4
21adenocarcinoma10.3
22cervix small cell carcinoma10.3
23cervical clear cell adenocarcinoma10.3
24cystic basal cell carcinoma10.3
25cervical endometrioid adenocarcinoma10.3
26verrucous carcinoma10.3
27basal cell carcinoma10.3
28retinoblastoma10.2
29cervix uteri carcinoma in situ10.2
30in situ carcinoma10.2
31lymphedema10.2
32myoma10.1
33adenosquamous carcinoma10.1
34leukemia10.1
35sarcoma10.1
36hiv/aids10.1
37nasopharyngitis10.1
38lymphangitis10.1
39keratinizing squamous cell carcinoma10.1
40septic arthritis10.1
41adenoiditis10.1
42fibrous histiocytoma10.1
43adenoid cystic carcinoma10.1
44anal squamous cell carcinoma10.1
45arthritis10.1
46cervical adenosquamous carcinoma10.1
47cervical squamous cell carcinoma10.1
48histiocytoma10.1
49brain glioma10.0
50urinary tract obstruction10.0

Graphical network of the top 20 diseases related to Cervical Cancer:



Diseases related to cervical cancer

Symptoms for Cervical Cancer

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Sources:
48OMIM
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Clinical features from OMIM:

603956

Drugs & Therapeutics for Cervical Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Cancer

Drug clinical trials:

Search ClinicalTrials for Cervical Cancer

Search NIH Clinical Center for Cervical Cancer

Search CenterWatch for Cervical Cancer

Genetic Tests for Cervical Cancer

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23GTR
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Genetic tests related to Cervical Cancer:

id Genetic test Affiliating Genes
1 Carcinoma of Cervix23

Anatomical Context for Cervical Cancer

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Cervical Cancer:

34
Cervix, Testes, Lymph node, Uterus, Breast, Endothelial, T cells, Lung, Bone, Prostate, Colon, Nk cells, Small intestine, Monocytes, Myeloid, Thyroid, Bone marrow, Ovary, Liver

FMA organs/tissues related to Cervical Cancer:

15
The cervix uteri or

Animal Models for Cervical Cancer or affiliated genes

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Publications for Cervical Cancer

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53PubMed
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Articles related to Cervical Cancer:

(show top 50)    (show all 1864)
idTitleAuthorsYear
1
Cytotoxic function of gamma delta (gamma/delta) T cells against pamidronate-treated cervical cancer cells. (24228383)
2013
2
Promoters of and barriers to cervical cancer screening in a rural setting in Tanzania. (24095307)
2013
3
The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling. (24145114)
2013
4
Women whose cervical intraepithelial neoplasia has been treated or resolved remain at continued high risk for cervical cancer. (23378629)
2013
5
Cellular retinol binding protein 1 could be a tumor suppressor gene in cervical cancer. (24040446)
2013
6
Ethics of "standard care" in randomised trials of screening for cervical cancer should not ignore scientific evidence and ground realities. (24152348)
2013
7
Correction: TACC3 Is Essential for EGF-Mediated EMT in Cervical Cancer. (24073191)
2013
8
Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer. (23405241)
2013
9
Concurrent chemoradiation with weekly gemcitabine and cisplatin for locally advanced cervical cancer. (24175831)
2013
10
Dysregulated expression of both the costimulatory CD28 and inhibitory CTLA-4 molecules in PB T cells of advanced cervical cancer patients suggests systemic immunosuppression related to disease progression. (22094905)
2012
11
The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-I_B signaling. (23091055)
2012
12
MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cells. (22634495)
2012
13
Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells. (21765464)
2012
14
Quality of life among Thai women diagnosed with cervical cancer and cervical intraepithelial neoplasia at King Chulalongkorn Memorial Hospital. (21863670)
2011
15
Human papillomavirus's physical state and cyclin A1 promoter methylation in cervical cancer. (21412159)
2011
16
Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy. (21330833)
2011
17
Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome. (21040567)
2010
18
DNA methylation and carcinogenesis of PRDM5 in cervical cancer. (20213097)
2010
19
Immunolabeling of the inhibin-I^A and -I^B subunit in normal and malignant human cervical tissue and cervical cancer cell lines. (21475087)
2010
20
Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme. (20423964)
2010
21
Topoisomerase I deficiency results in chromosomal alterations in cervical cancer cells. (20944095)
2010
22
The role and mechanism of CXCR4 and its ligand SDF-1 in the development of cervical cancer metastasis]. (18851783)
2008
23
Early growth response-1 mediates downregulation of telomerase in cervical cancer. (18460021)
2008
24
Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha. (18559093)
2008
25
Immunohistochemical expression of p16 and herpes simplex virus type 2 in squamous intraepithelial lesions and cervical cancer]. (19142477)
2008
26
Methyl jasmonate induces cell death with mixed characteristics of apoptosis and necrosis in cervical cancer cells. (18599197)
2008
27
Molecular profiling of cervical cancer progression. (17242701)
2007
28
Relationship between the expression of P-glycoprotein, glutathione S-transferase-pi and thymidylate synthase proteins and adenosine triphosphate tumor chemosensitivity assay in cervical cancer]. (17537309)
2007
29
Expression of IP-10 related to angiogenesis in uterine cervical cancers. (17505511)
2007
30
Uncoupling of promoter methylation and expression of Period1 in cervical cancer cells. (17592726)
2007
31
Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer. (17467893)
2007
32
Polymorphic amino acids at codons 9 and 37 of HLA-DQB1 alleles may confer susceptibility to cervical cancer among Chinese women. (16425277)
2006
33
Promoter methylation of p16, DAPK, CDH1, and TIMP-3 genes in cervical cancer: correlation with clinicopathologic characteristics. (16803511)
2006
34
Interleukin-6 polymorphisms and the risk of cervical cancer. (16803517)
2006
35
Clusterin confers paclitaxel resistance in cervical cancer. (16890274)
2006
36
A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions. (16189158)
2005
37
Pro-apoptotic efficiencies of three reconstructed human caspase-8 on cervical cancer cell line HeLa]. (15694025)
2005
38
Prognostic relevance of TGF-beta1 and PAI-1 in cervical cancer. (15386352)
2004
39
Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. (15585135)
2004
40
No alteration in NK function or zeta chain expression in NK and T cells of cervical cancer patients. (12694665)
2003
41
Codon 72 polymorphism of p53 in Israeli Jewish cervical cancer patients and healthy women. (12445252)
2002
42
Implication of a reflected image illustration for pelvic lymphadenectomy on uterine cervical cancer with situs inversus totalis. (11855896)
2002
43
Oxidative stress and tumor markers in cervical cancer patients. (14972792)
2002
44
IFNalpha sensitizes ME-180 human cervical cancer cells to TNFalpha-induced apoptosis by inhibiting cytoprotective NF-kappaB activation. (11322949)
2001
45
Cyclooxygenase-2 is overexpressed in human cervical cancer. (11234900)
2001
46
Adenovirus-mediated p21((WAF1/SDII/CIP1)) gene transfer induces apoptosis of human cervical cancer cell lines. (10233960)
1999
47
Mechanisms of arsenic trioxide induced apoptosis of human cervical cancer HeLa cells and protection by Bcl-2. (18726487)
1999
48
Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in uterine cervical cancers. (10098767)
1999
49
A 2-week pretreatment with 13-cis-retinoic acid + interferon-alpha-2a prior to definitive radiation improves tumor tissue oxygenation in cervical cancers. (9830438)
1998
50
Human papillomavirus DNA and p53 status in stage IB bulky cervical cancer. (7962045)
1994

Variations for Cervical Cancer

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Cervical Cancer:

1
id Gene Name Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.746C> G (p.Ser249Cys)single nucleotide variantPathogenicrs121913483GRCh37Chr 4, 1803568: 1803568

Expression for genes affiliated with Cervical Cancer

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Cancer

Search GEO for disease gene expression data for Cervical Cancer.

Pathways for genes affiliated with Cervical Cancer

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51PathCards, 5Cell Signaling Technology, 31KEGG
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Pathways related to Cervical Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1FGFR3, HIF1A, VEGFC
29.9FGFR3, WNT6, HIF1A, VEGFC

Compounds for genes affiliated with Cervical Cancer

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46Novoseek
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Compounds related to Cervical Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glyceraldehyde 3-phosphate4610.0EEF1A1, HIF1A, VEGFC
2paraffin469.5FGFR3, CD82, HIF1A, VEGFC

GO Terms for genes affiliated with Cervical Cancer

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17Gene Ontology
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Cellular components related to Cervical Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:00574110.0ST20, BRI3BP, LETMD1

Biological processes related to Cervical Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of neuroblast proliferationGO:00205210.2HIF1A, VEGFC
2digestive tract morphogenesisGO:0485469.9FGFR3, HIF1A

Molecular functions related to Cervical Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.4FGFR3, VEGFC, HIF1A, MCM3, POU2F3, EEF1A1

Products for genes affiliated with Cervical Cancer

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  • Antibodies
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  • Antibodies

Sources for Cervical Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet