Cervical Cancer malady

MedlinePlus: The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. cervical cancer is caused by several types of a virus called human papillomaviruses (hpv). the virus spreads through sexual contact. most women's bodies are able to fight hpv infection. but sometimes the virus leads to cancer. you're at higher risk if you smoke, have many children, use birth control pills for a long time, or have hiv infection. cervical cancer may not cause any symptoms at first, but later, you may have pelvic pain or bleeding from the vagina. it usually takes several years for normal cells in the cervix to turn into cancer cells. your health care provider can find abnormal cells by doing a pap test - examining cells from the cervix under a microscope. by getting regular pap tests and pelvic exams you can find and treat changing cells before they turn into cancer. a vaccine for girls and young women protects against the four types of hpv that cause most cervical cancers. nih: national cancer institute²³

MalaCards: Cervical Cancer, also known as neoplasm of uterine cervix (disorder), is related to cervicitis and carcinoma. An important gene associated with Cervical Cancer is PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), and among its related pathways are Cell Cycle / Checkpoint Control and Apoptosis Signaling Pathways. The drugs prednisone and prednisolone tebutate and the compounds calcium and paraffin have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and lymph node, and related mouse phenotypes are cellular and mortality/aging.

CDC: Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.²

Wikipedia: Cervical cancer is a malignant neoplasm arising from cells originating in the cervix uteri. One of the...⁴⁴ more...

Aliases & Descriptions:

cervical cancer 6 7 32 23 neoplasm of uterine cervix (disorder) 6 tumor of the cervix uteri 6 uterine cervical neoplasm 43 cervix uteri cancer 6 neoplasms cervical 32

cervical neoplasm 6 cervix carcinoma 43 cervix cancer 6 neoplasms 43

Diseases related to cervical cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1545)

id	Related Disease	Score	Top Affiliating Genes
1	cervicitis	154.1	ZNF350, ZNF217, ZNF434, PIK3CA, PIP5KL1, PIK3CG
2	carcinoma	112.7	ZNF217, PIK3CA, PIK3CG, PIN1, LRIG1, RFC1
3	prostatitis	85.8	PIK3CA, PIK3CG, PIN1, LRIG1, RFC1, NCL
4	leukemia	84.0	PIK3CA, PIK3CG, PIN1, RFC1, NCL, NCR1
5	pancreatitis	83.1	PIK3CA, PIK3CG, PIN1, NCL, RELA, VTN
6	adenocarcinoma	79.0	ZNF217, PIK3CA, PIK3CG, PIN1, NCL, NCR2
7	melanoma	74.2	PIK3CA, PIK3CG, NCL, PDCD1, RELA, VTN
8	neuronitis	74.0	PIK3CA, PIK3CG, PIN1, NCL, RELA, SFN
9	hepatocellular carcinoma	73.9	PIK3CA, PIK3CG, PIN1, NCL, NCR3, PDCD1
10	gastric cancer	71.7	PIK3CA, PIP5KL1, PIK3CG, PIN1, RFC1, NCL
11	thyroiditis	71.7	PIK3CA, PIK3CG, PIN1, RFC1, RELA, VTN
12	esophagitis	69.5	PIK3CA, PIK3CG, PIN1, RELA, SFN, SFRP1
13	hypoxia	62.9	ZNF217, PIK3CA, PIP5KL1, PIK3CG, RELA, VTN
14	breast carcinoma	61.9	ZNF217, PIK3CA, PIK3CG, NCL, VTN, SFN
15	lung carcinoma	61.5	PIK3CA, PIK3CG, PCNA, RB1, RBL2, RBL1
16	sarcoma	59.8	PIK3CA, PIK3CG, RELA, VTN, PCNA, RB1
17	adenoma	58.9	PIK3CA, SFRP1, SFRP2, PCNA, RB1, SETD2
18	ovarian carcinoma	58.1	PIK3CA, PIP5KL1, PIK3CG, RELA, VTN, PCNA
19	myeloid leukemia	57.0	PIK3CA, PIK3CG, PIN1, NCL, NCR1, NCR2
20	cervical carcinoma	56.2	PIK3CA, PIK3CG, PDCD1, RECQL4, RELA, VTN
21	lymphocytic leukemia	50.9	PIK3CA, PIK3CG, NCL, RELA, SFN, SFRP1
22	endometrial cancer	50.0	PIK3CA, PIK3CG, SFN, PCNA, RB1, RBL2
23	fibrosis	48.9	PIK3CA, PIK3CG, PIN1, RELA, VTN, PCNA
24	oral cancer	48.7	SFN, SFRP1, SFRP2, PCNA, RB1, SERPINB3
25	esophageal cancer	48.6	PIK3CA, PIK3CG, SFRP1, PCNA, RB1, RBL1
26	osteosarcoma	48.6	PIK3CA, PIK3CG, RFC1, RECQL4, RELA, VTN
27	endometrial carcinoma	48.4	PIK3CA, PIK3CG, RELA, SFN, SFRP1, PCNA
28	epithelial ovarian cancer	48.2	PIK3CA, PIK3CG, RELA, SFN, RB1, SERPINB5
29	colon carcinoma	48.1	PIK3CA, PIK3CG, NCL, VTN, SETD2, SERPINF1
30	laryngitis	47.7	PIK3CA, RECQL4, RELA, SFN, PCNA, RB1
31	renal cell carcinoma	47.6	PIK3CA, PDCD1, RELA, SFRP1, PCNA, SETD2
32	acute myeloid leukemia	47.4	PIK3CA, PIK3CG, PIN1, NCL, NCR1, NCR2
33	thyroid carcinoma	46.6	PIK3CA, PIK3CG, SFN, PCNA, RB1, SERPINB5
34	retinoblastoma	46.3	PIK3CA, PIK3CG, RFC1, NCL, SFRP2, PCNA
35	astrocytoma	44.8	PIK3CA, PIK3CG, RELA, VTN, PCNA, RB1
36	cervical intraepithelial neoplasia	44.7	PIK3CA, PCNA, RB1, RBL1, VEGFA, VEGFC
37	lymphoblastic leukemia	44.6	PIK3CA, PIK3CG, RFC1, RELA, SFRP1, PCNA
38	thyroid cancer	44.3	PIK3CA, PIK3CG, RFC1, PCNA, RBBP4, SERPINB5
39	anemia	44.3	PDCD1, RELA, PCNA, RB1, SERPINC1, SETD2
40	cerebritis	43.7	PIK3CG, RELA, VTN, PCNA, SERPINC1, SETD2
41	liver cancer	43.4	PIK3CG, PIN1, KIAA1524, SFRP2, RB1, RBL2
42	diffuse large b-cell lymphoma	43.0	PIK3CA, PIK3CG, RELA, RB1, BRCA1, BRCA2
43	papilloma	42.8	PIN1, PCNA, RB1, RBL2, RBL1, SERPINB3
44	meningioma	42.7	PIK3CG, RFC1, NCL, RECQL4, SFRP1, PCNA
45	cholangiocarcinoma	41.7	PIK3CA, PIK3CG, SFN, PCNA, RB1, RBL1
46	acute leukemia	41.6	PIK3CA, NCL, RB1, SERPINC1, SERPINA3, NAT2
47	herpes simplex	40.9	PIK3CA, PIK3CG, NCL, NCR1, NCR2, PCNA
48	psoriasis	40.9	LRIG1, RFC1, VTN, PCNA, SERPINC1, SERPINB3
49	atherosclerosis	40.7	PIK3CG, PDCD1, VTN, PCNA, SERPINC1, SETD2
50	germ cell tumor	40.5	PCNA, RB1, BRCA2, VEGFA, RARB, RASSF1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to cervical cancer:

²²

MGI Mouse Phenotypes related to cervical cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	34.0	PIK3CA, PIK3CG, PIN1, LRIG1, PDCD1, RECQL4
2	mortality/aging	MP:0010768	33.5	PIK3CA, NCR1, PDCD1, RECQL4, RELA, SFN
3	homeostasis/metabolism phenotype	MP:0005376	30.6	PIK3CA, PIK3CG, RELA, VTN, SFRP1, SFRP2
4	growth/size phenotype	MP:0005378	29.2	PIK3CA, PIK3CG, PIN1, RECQL4, RELA, SFN
5	hematopoietic system phenotype	MP:0005397	26.3	NCR1, PDCD1, RECQL4, SFN, SFRP1, PCNA
6	nervous system phenotype	MP:0003631	26.1	LRIG1, PDCD1, RELA, SFRP1, SFRP2, PCDH10
7	immune system phenotype	MP:0005387	24.9	RECQL4, SFN, SFRP1, RBL1, BSG, BRCA1
8	cardiovascular system phenotype	MP:0005385	24.0	PIK3CA, PIK3CG, PDCD1, RELA, SFRP1, SFRP2
9	integument phenotype	MP:0010771	23.5	PIK3CG, PIN1, LRIG1, RECQL4, RELA, SFN
10	embryogenesis phenotype	MP:0005380	21.5	PIK3CA, RECQL4, SFN, SFRP1, SFRP2, BUB3
11	digestive/alimentary phenotype	MP:0005381	21.3	LRIG1, RECQL4, SFN, RB1, RBL1, SERPINF1
12	behavior/neurological phenotype	MP:0005386	21.3	PIK3CA, RB1, RBL1, BRCA2, VEGFB, LMX1A
13	tumorigenesis	MP:0002006	21.2	PIK3CA, LRIG1, RECQL4, SFN, BUB3, RB1
14	normal phenotype	MP:0002873	20.7	LRIG1, NCR1, RELA, VTN, SFRP2, RBL2
15	vision/eye phenotype	MP:0005391	20.2	PIK3CA, PIN1, PDCD1, RECQL4, RELA, SFN
16	skeleton phenotype	MP:0005390	19.3	PIK3CG, RELA, SFN, SFRP1, PCOLCE, RB1
17	muscle phenotype	MP:0005369	19.2	PIK3CA, PIK3CG, PDCD1, RELA, SFRP2, PCOLCE
18	reproductive system phenotype	MP:0005389	18.8	PIK3CA, SFN, SFRP2, RBL2, RBL1, RBMS1
19	limbs/digits/tail phenotype	MP:0005371	16.6	LRIG1, RECQL4, RELA, SFN, SFRP1, SFRP2
20	renal/urinary system phenotype	MP:0005367	16.6	PDCD1, BRCA1, MYLK, RARA, RARB, CLU
21	no phenotypic analysis	MP:0003012	16.3	SFRP1, SFRP2, PCNA, RB1, RBL2, RBL1
22	craniofacial phenotype	MP:0005382	15.6	LRIG1, RECQL4, RBL1, LMX1A, BMI1, PAX1
23	endocrine/exocrine gland phenotype	MP:0005379	14.8	LRIG1, SFN, SFRP2, RBL2, RBL1, BRCA1
24	hearing/vestibular/ear phenotype	MP:0005377	14.6	SFN, RB1, LMX1A, MYC, RARA, RARB
25	pigmentation phenotype	MP:0001186	13.0	RECQL4, RB1, SERPINC1, SERPINF1, BRCA1, LMX1A
26	respiratory system phenotype	MP:0005388	12.3	BRCA1, BID, YY1, CDK5, ITGB3, INSR
27	liver/biliary system phenotype	MP:0005370	11.6	SFN, RBL1, SERPINC1, VEGFA, BID, ZFP36
28	adipose tissue phenotype	MP:0005375	11.4	PIK3CA, SFRP1, BUB3, RB1, RBL1, SERPINE1
29	other phenotype	MP:0005395	11.3	RARA, RARB, CLU, CDKN2A, ITGB1, ITGB3

Articles related to cervical cancer:

(show top 50)    (show all 1025)

id	Title	Authors	Year	Affiliating Genes
1	Epigenetic regulation of the potential tumor suppress or gene, hLHX6.1, in human cervical cancer. (21240459)	Jung S.... Lee M.S.	2011	LHX6
2	Phase I trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer. (20145183)	Kunos C.A.... Kinsella T.J.	2010	NR2E3, HBG2
3	Overexpression of PIP5KL1 suppresses the growth of hu man cervical cancer cells in vitro and in vivo. (19947914)	Shi L.... Huang C.	2010	PIP5KL1
4	Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome. (21040567)	Yoo C.W.... Song Y.J.	2010	CA12
5	The expression of APE1 and its correlation with prognostic significance after 252Cf radiotherapy in cervical cancer (19292061)	Qing Y.... Shan J.L.	2009	APEX1
6	Low NKp30, NKp46 and NKG2D expression and reduced cyt otoxic activity on NK cells in cervical cancer and precursor lesions. (19531227)	Garcia-Iglesias T.... Daneri-Navarro A.	2009	CD244, NCR2, KLRK1
7	Markers of angiogenesis in high-risk, early-stage cervical cancer: A Gynecologic Oncology Group study. (19110305)	Randall L.M.... Fruehauf J.P.	2009	THBS1, PECAM1
8	Expression of heat shock protein 60 kDa is upregulate d in cervical cancer. (19568603)	Hwang Y.J.... Kim D.Y.	2009	HSPD1
9	Outcome of treatment of human HeLa cervical cancer ce lls with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment. (19180585)	Wesierska-Gadek J.... Wandl S.	2009	BIRC5
10	FAS -1377 G/A polymorphism and the risk of lymph node metastasis in cervical cancer. (18068525)	Kang S.... Park S.Y.	2008	FAS, FASLG
11	Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells. (18339208)	Jankowska A.... Warchol J.B.	2008	CGB
12	Role of protease activated receptor-2 in lymph node metastasis of uterine cervical cancers. (18937843)	Jahan I.... Tamaya T.	2008	F2RL1
13	Effects of 5-aminolevulinic acid photodynamic therapy on cervical cancer: in vivo experiment with nude mice (18646722)	He G.F.... Xiao C.	2008	BIRC5
14	Microarray analysis of normal cervix, carcinoma in si tu, and invasive cervical cancer: identification of candidate genes in pathogen esis of invasion in cervical cancer. (18217980)	Song J.Y.... Lee K.W.	2008	ARHGAP8
15	CCR5-Delta32 polymorphism and susceptibility to cervical cancer: association with early stage of cervical cancer. (18543610)	Singh H.... Mittal B.	2008	CCR5
16	Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic mice. (17600126)	Lu Z.H.... Arbeit J.M.	2007	SETD2
17	Expression and significance of P16INK4A and PTEN in high-risk human papillomavirus-related cervical cancer (17672936)	Zhao X.L.... Kong X.D.	2007	PTEN, CDKN2A
18	Geographic distribution of cervical cancer-associated human leucocyte antigens and cervical cancer incidence in Finland. (17945045)	Castro F.A.... Lehtinen M.	2007	HLA-S
19	Elevated expression of the oncogene c-fms and its ligand, the macrophage colony-stimulating factor-1, in cervical cancer and the role of transforming growth factor-beta1 in inducing c-fms expression. (17332318)	Kirma N.... Tekmal R.R.	2007	TGFB1, CSF1R, CSF1
20	Stat3 activation in human endometrial and cervical cancers. (17311011)	Chen C.L.... Lin J.	2007	STAT3
21	Up-regulation of proliferating cell nuclear antigen (PCNA) is closely associated with high-risk human papillomavirus (HPV) and progression of cervical intraepithelial neoplasia (CIN), but does not predict disease outcome in cervical cancer. (17098349)	Branca M.... Syrjanen K.	2007	PCNA
22	Infection of human papillomavirus and overexpression of dihydrodiol dehydrogenase in uterine cervical cancer. (16427687)	Ueda M.... Chow K.C.	2006	DHDH
23	Effects of Smac gene over-expression on the radiotherapeutic sensitivities of cervical cancer cell line HeLa. (15740652)	Zheng L.D.... Wang Z.H.	2005	DIABLO
24	Potentiation of the radiation effect with genistein i n cervical cancer cells. (16083949)	Yashar C.M.... Gercel-Taylor C.	2005	MCL1
25	Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. (15629771)	Santin A.D.... Pecorelli S.	2005	TGFB1, SERPINF1, UBE2C
26	Loss of net as repressor leads to constitutive increased c-fos transcription in cervical cancer cells. (15548518)	van Riggelen J.... Rosl F.	2005	FOS
27	Prognostic significance of the thymidine phosphorylate/dihydropyrimidine dehydrogenase ratio in invasive cervical cancer. (16259080)	Kodama J.... Hiramatsu Y.	2005	DPYD
28	Hypoxia correlates with angiogenesis in cervical cancers. (15729599)	Tanaka H.... Nakamura Y.	2005	VEGFA
29	Correlation between p14(ARF)/p16(INK4A) expression and HPV infection in uterine cervical cancer. (15312681)	Kanao H.... Murata Y.	2004	TP53, CDKN2A
30	Apoptosis in cervical cancer cells: implications for adjunct anti-estrogen therapy for cervical cancer. (15517869)	Chen D.... Auborn K.J.	2004	BCL2
31	A relationship between Matrix metalloproteinase-1 (MMP-1) promoter polymorphism and cervical cancer progression. (14550952)	Nishioka Y.... Kudo R.	2003	MMP1
32	Interferon, alpha 17 (IFNA17) Ile184Arg polymorphism and cervical cancer risk. (12490311)	Kim J.W.... Lee H.P.	2003	IFNA17
33	Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. (14678972)	Brake T.... Lambert P.F.	2003	MCM7
34	Expression of Ku80 in cervical cancer correlates with response to radiotherapy and survival. (12902903)	Harima Y.... Ohnishi T.	2003	XRCC5
35	Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells. (11852051)	Shen M.R.... Ellory J.C.	2002	SLC9A1, SLC4A2
36	Interleukin-10 promoter polymorphisms and cervical cancer risk in Korean women. (12104048)	Roh J.W.... Lee H.P.	2002	IL10
37	Platelet-derived endothelial cell growth factor in keratinizing-type squamous cell uterine cervical cancer. (11115576)	Matsumoto Y.... Wakasa K.	2001	TYMP
38	Molecular quantification and mapping of lymph-node micrometastases in cervical cancer. (11197354)	Van Trappen P.O.... Jacobs I.J.	2001	KRT19
39	Lymphatic microvessel density as a novel prognostic factor in early-stage invasive cervical cancer. (11241307)	Birner P.... Oberhuber G.	2001	PDPN
40	p53 polymorphism and human papillomavirus infection in Hong Kong women with cervical cancer. (10895031)	Wong Y.F.... Chang A.M.	2000	TP53
41	Mechanisms of arsenic trioxide induced apoptosis of human cervical cancer HeLa cells and protection by Bcl-2. (18726487)	Deng Y.... Wu M.	1999	BCL2
42	HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes. (10208853)	Alami Y.... Clausse N.	1999	HOXA7
43	Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type. (9521167)	Muller C.Y.... Minna J.D.	1998	FHIT
44	Quantitative determination of the epidermal growth factor receptor in cervical cancer and normal cervical epithelium by 2-color flow cytometry: evidence for down-regulation in cervical cancer. (9291423)	Kimmig R.... Hepp H.	1997	EGFR
45	The expression of c-myc protein in uterine cervical cancer: a possible prognostic indicator (8754393)	Wu H.J.	1996	MYC
46	Serum levels of cytokeratin 19 fragments in cervical cancer. (8979101)	Nasu K.... Miyakawa I.	1996	KRT19
47	p53 tumor suppressor gene protein expression in cervical cancer: relationship to prognosis. (8674566)	Bremer G.L.... Arends J.W.	1995	TP53
48	Prognostic value of cytokeratins and carcinoembryonic antigen expression in primary surgically treated cervical cancer. (7516638)	Kainz C.... Reinthaller A.	1994	PSG2
49	Augmenting effect of sizofiran on the immunofunction of regional lymph nodes in cervical cancer. (1739919)	Shimizu Y.... Masubuchi K.	1992	IL2RB
50	Immunohistochemistry in stage FIGO III cervical cancer: prognostic value of tumor associated antigens and intermediate filaments. (1284198)	Gitsch G.... Breitenecker G.	1992	PSG2

Genes related to cervical cancer according to GeneCards:

(show top 50)    (show all 834)

id	Symbol	Description	Score	GeneCards Section Context
1	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0	Publications, Summaries
2	ST20	suppressor of tumorigenicity 20	11.0	Aliases & Descriptions, Publications, Expressions
3	LETMD1	LETM1 domain containing 1	11.0	Aliases & Descriptions, Publications
4	FUNDC2	FUN14 domain containing 2	11.0	Aliases & Descriptions
5	BRI3BP	BRI3 binding protein	11.0	Aliases & Descriptions
6	PAX1	paired box 1	11.0	Summaries, Publications
7	POU2F3	POU class 2 homeobox 3	11.0	Summaries, Publications
8	TMEM50A	transmembrane protein 50A	11.0	Aliases & Descriptions
9	HEXB	hexosaminidase B (beta polypeptide)	11.0	Aliases & Descriptions, Orthologs
10	ZNF434	zinc finger protein 434	11.0	Aliases & Descriptions
11	MRPS11	mitochondrial ribosomal protein S11	11.0	Aliases & Descriptions
12	ZAK	sterile alpha motif and leucine zipper containing kinase AZK	11.0	Aliases & Descriptions
13	TTC23	tetratricopeptide repeat domain 23	11.0	Aliases & Descriptions
14	MCM3	minichromosome maintenance complex component 3	11.0	Aliases & Descriptions
15	EEF1A1	eukaryotic translation elongation factor 1 alpha 1	11.0	Aliases & Descriptions, Publications
16	RBMS1	RNA binding motif, single stranded interacting protein 1	11.0	Aliases & Descriptions
17	WNT6	wingless-type MMTV integration site family, member 6	11.0	Summaries
18	FGFR3	fibroblast growth factor receptor 3	11.0
19	CD82	CD82 molecule	11.0	Publications
20	VEGFC	vascular endothelial growth factor C	11.0	Publications
21	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
22	CCNB1	cyclin B1	11.0	Publications
23	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
24	FHIT	fragile histidine triad	11.0	Publications
25	CADM1	cell adhesion molecule 1	11.0	Publications
26	SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	11.0	Publications
27	POU4F1	POU class 4 homeobox 1	11.0	Publications
28	HLA-S	major histocompatibility complex, class I, S (pseudogene)	11.0	Publications
29	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	11.0	Publications
30	EBAG9	estrogen receptor binding site associated, antigen, 9	11.0	Publications
31	AMHR2	anti-Mullerian hormone receptor, type II	11.0	Publications
32	KRT19	keratin 19	11.0	Publications
33	RECQL4	RecQ protein-like 4	11.0	Publications
34	TYMP	thymidine phosphorylase	11.0	Publications
35	HES1	hairy and enhancer of split 1, (Drosophila)	11.0	Publications
36	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
37	TERC	telomerase RNA component	11.0	Publications
38	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
39	ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	11.0	Publications
40	UBE3A	ubiquitin protein ligase E3A	11.0	Publications
41	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
42	IRF1	interferon regulatory factor 1	11.0	Publications
43	BAG1	BCL2-associated athanogene	11.0	Publications
44	KRT10	keratin 10	11.0	Publications
45	CDC6	cell division cycle 6 homolog (S. cerevisiae)	11.0	Publications
46	BAK1	BCL2-antagonist/killer 1	11.0	Publications
47	CA9	carbonic anhydrase IX	11.0	Publications
48	WNT2	wingless-type MMTV integration site family member 2	11.0	Publications
49	NOTCH1	notch 1	11.0	Publications
50	KRT14	keratin 14	11.0	Publications

Pathways related to cervical cancer according to GeneDecks:

(show top 50)    (show all 303)

id	Pathway	Score	Top Affiliating Genes
1	Cell Cycle / Checkpoint Control3	15.0	PIN1, RECQL4, PCNA, BUB3, RB1, BRCA1
2	Apoptosis Signaling Pathways37	14.2	SFN, BID, BIRC2, BIRC3, BIRC5, BIRC7
3	Tec Kinases Signaling36	13.9	VEGFB, VEGFC, BMP6, BCL2, BAX, CD28
4	Small cell lung cancer20	13.6	PIK3CA, PIK3CG, RELA, RB1, MYC, RARB
5	Angiogenesis3	13.4	SERPINB5, VEGFB, VEGFC, JAG1, ITGA5, ITGAV
6	Rho Family GTPases36	13.1	VEGFB, VEGFC, MYLK, BMP6, BCL2, BAX
7	Mitochondrial Apoptosis36	12.9	VEGFB, VEGFC, BMP6, BID, BIRC2, BCL2
8	Selected targets of p5310	12.7	SERPINB5, BCL2, BAX, CDKN1A, CDK2, CDK4
9	PAK Pathway36	12.7	VEGFB, VEGFC, MYLK, BMP6, BCL2, BAX
10	TGF-Beta Pathway36	12.6	VEGFB, VEGFC, BMP6, BCL2, BAX, JUN
11	Toxoplasmosis20	12.4	PIK3CA, PIK3CG, RELA, BIRC2, BIRC3, BCL2
12	Breast Cancer Regulation by Stathmin136	12.4	VEGFB, FGF10, FGF2, FGFR2, FGFR3, GRB2
13	Glioma Invasiveness36	12.3	VTN, VEGFB, VEGFC, BMP6, CD44, ITGA1
14	STAT3 Pathway36	12.3	MYC, BMP6, BCL2, BAX, CD28, CDKN1A
15	Apoptosis and survival TNFR1 signaling pathway10	12.3	RELA, BID, BIRC2, BIRC3, CHUK, BAX
16	Chronic myeloid leukemia20	12.2	PIK3CA, PIK3CG, RELA, RB1, MYC, BCL2L1
17	Regulation of eIF4 and p70S6K36	12.2	VEGFC, BAX, CD80, ITGA1, ITGA2, ITGA3
18	Immune response IL-2 activation and signaling pathway10	11.7	PIK3CA, MYC, CHUK, JUN, JUNB, JUND
19	Glioblastoma Multiforme36	11.7	RB1, CDKN1A, CDK2, CDKN1B, CDK4, MGMT
20	NF-KappaB Family Pathway36	11.7	RELA, VEGFB, VEGFC, BMP6, BCL3, CHUK
21	NF-KappaB (p50-p65) Pathway36	11.7	RELA, VEGFB, VEGFC, BMP6, CHUK, FGF10
22	PGC1Alpha Pathway36	11.7	BMP6, BCL2, BAX, CD80, INSR, IL10RA
23	CDC42 Pathway36	11.7	MYLK, JUN, CDH1, ITGA1, ITGA2, ITGA3
24	Immune response_IL-2 activation and signaling pathway41	11.4	PIK3CA, RELA, MYC, CHUK, JUN, JUNB
25	Hepatitis C20	11.4	PIK3CA, PIK3CG, RELA, CHUK, CDKN1A, IRF1
26	Type I diabetes mellitus20	11.4	CD28, CD86, CD80, GZMB, IL12A, IL12B
27	SOCS Pathway36	11.4	VEGFB, VEGFC, BMP6, BCL2, UBE2C, BAX
28	Allograft rejection20	11.3	CD28, CD86, CD80, GZMB, IL10, IL12A
29	Non-small cell lung cancer20	11.3	PIK3CA, PIK3CG, RB1, RASSF1, CDKN2A, CDK4
30	Apoptotic Pathways in Synovial Fibroblasts36	11.3	VEGFB, VEGFC, BMP6, CFLAR, FGF10, FGF2
31	Nanog in Mammalian ESC Pluripotency36	11.3	VEGFB, VEGFC, BMP6, INSR, FGF10, FGF2
32	mTOR Pathway36	11.2	VEGFB, VEGFC, BMP6, INSR, FGF10, FGF2
33	Signal transduction_PTEN pathway41	11.2	PCNA, ITGA5, ITGB1, IGF1R, CASP9
34	14-3-3 Induced Intracellular Signaling36	11.2	VEGFB, VEGFC, JUN, INSR, FGF10, FGF2
35	RAR-Gamma-RXR-Alpha Degradation36	11.2	UBE3A, CD80, IL12A, IL15, IL2, IL24
36	Cell cycle_Regulation of G1/S transition (part 2)41	11.1	RELA, RB1, RBL2, RBL1, CHUK, JUN
37	Development_EGFR signaling pathway41	11.0	PIK3CA, MYC, CHUK, JUN, MMP2, MMP9
38	Immune response IL-1 signaling pathway10	11.0	RELA, SERPINE1, CHUK, JUN, JUNB, JUND
39	TGF-beta Signaling Pathways37	11.0	PIK3CG, RELA, MYC, MTOR, JUN, JUNB
40	PEDF Induced Signaling36	10.9	RELA, SERPINF1, BMP6, BCL2, BCL2L1, CHUK
41	Renin-Angiotensin Pathway36	10.9	VEGFB, VEGFC, BMP6, CHUK, JUN, FOS
42	Signaling Involved in Cardiac Hypertrophy36	10.8	MYLK, JUN, ITGA1, ITGA2, ITGA3, ITGA5
43	Leishmaniasis20	10.8	RELA, JUN, ITGB1, FOS, FCGR2A, IL10
44	T cell receptor signaling pathway20	10.6	PIK3CA, PIK3CG, PDCD1, RELA, CHUK, JUN
45	Rheumatoid arthritis20	10.6	VEGFA, VEGFB, JUN, CD28, CD86, CD80
46	Immune response_Oncostatin M signaling via MAPK in human cells41	10.3	JUN, JUNB, JUND, MMP1, MMP3, FOS
47	Estrogen Pathway36	10.3	BRCA1, VEGFB, VEGFC, BMP6, BCL2, CHUK
48	Chagas disease (American trypanosomiasis)20	10.2	PIK3CA, PIK3CG, RELA, SERPINE1, CHUK, CFLAR
49	Immune response MIF-mediated glucocorticoid regulation10	9.4	RELA, CHUK, JUN, MMP1, FOS, MIF
50	p53 signaling pathway20	INF	SFN, SERPINB5, SERPINE1, BID, BAX, ATM

Compounds related to cervical cancer according to GeneDecks:

(show top 50)    (show all 441)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	29.5	PIN1, NCL, RELA, VTN, SFN, RCN2
2	paraffin32	22.2	RELA, PCNA, RB1, SERPINB5, SERPINA1, SERPINA3
3	nitric oxide32 9 18 9	24.9	RB1, SERPINB5, SERPINF1, SERPINA1, NAT2, VEGFC
4	atp32	21.7	PIK3CA, RFC1, NCL, VTN, RB1, RBL2
5	thymidine32 18	20.0	PIK3CA, PCNA, RB1, RBL1, SERPINA1, BRCA1
6	pd 98,05932	17.3	PIK3CA, PIK3CG, NCL, VTN, RB1, SETD2
7	5-aza-2deoxycytidine32	17.0	SFRP1, PCNA, SERPINB5, BRCA1, BNIP3, MYC
8	proline32	16.7	PIN1, SETD2, BSG, BRCA1, BRCA2, CLU
9	arsenite32 18	16.8	PIK3CA, PIK3CG, PCNA, SETD2, VEGFA, MYC
10	cholesterol32 9 18 9	18.7	PIK3CA, VTN, RB1, SERPINA1, SERPINE1, SERPINA3
11	adpribose32	15.5	PIK3CA, PIK3CG, PCNA, RB1, BRCA1, BRCA2
12	creatinine32	15.4	PCNA, SERPINC1, SERPINA1, SERPINE1, SERPINA3, BMP6
13	iron32 18	16.3	SETD2, SERPINA1, SERPINA3, PAOX, CHUK, MUC16
14	flavopiridol32 9 9	17.0	PIK3CG, RB1, RBL1, VEGFA, BID, BIRC5
15	methionine32	14.8	SERPINF1, SERPINA1, SERPINA3, RASSF1, PARK7, CHGA
16	estradiol32 9 18 9	17.8	PCNA, RB1, SERPINE1, SERPINA3, BRCA1, BRCA2
17	gemcitabine32 34 9 9	17.6	PCNA, BRCA1, VEGFA, BNIP3, MYC, BID
18	calcitriol32 42 9 18 9	18.2	RB1, MYC, BMP6, RARA, RARB, CLU
19	adp32 18	14.9	PIK3CA, PIK3CG, RFC1, VTN, SERPINC1, MYLK
20	phosphatidylserine32 9 9	15.9	BID, PARP1, BCL2, BAK1, P2RX7, CDK2
21	noxa32	13.8	BID, BIRC5, BCL2, BCL2L1, BAK1, BAX
22	arachidonic acid32 9 18 9	16.6	PIK3CA, SERPINA1, MYLK, BCL2L1, MTOR, S100A8
23	cytarabine32 34 9 9	16.4	PCNA, RB1, MYC, BCL2, BCL2L1, MUC1
24	nocodazole32 42 9 9	16.2	PIN1, NCL, VTN, BRCA1, RAN, BIRC5
25	heparan sulfate32 18	14.2	NCL, VTN, SERPINC1, SERPINE1, BSG, VCAN
26	2-methoxyestradiol32 18	14.1	PCNA, SETD2, BID, BCL2, BCL2L1, BAX
27	p00332	13.0	RB1, SERPINA1, SERPINE1, BRCA1, BRCA2, RASSF1
28	aspirin32 34 18	14.9	VTN, PCNA, SERPINC1, SERPINB5, SERPINE1, BMP6
29	benzo(a)pyrene32	12.7	RB1, NAT2, BRCA1, RARB, XRCC1, XPC
30	carboplatin32 34 9 9	15.5	RB1, BRCA1, VEGFA, BID, PARP1, BCL2
31	17-(allylamino)-17-demethoxygeldanamycin32	12.4	SETD2, BIRC5, CDKN1A, CDK4, CDH1, ANXA5
32	hoechst 3334232	12.3	NCL, PCNA, BIRC5, PARP1, BCL2, BAX
33	azathioprine32 34 9 9	15.2	PCNA, RARB, RASSF1, MTHFR, CDKN2A, CD44
34	phorbol32	12.2	MYC, CHGA, CHUK, JUN, JUNB, JUND
35	topotecan32 9 9	13.9	SETD2, BRCA1, RAN, BIRC5, PARP1, BCL2
36	indole-3-carbinol32	11.9	BRCA1, BRCA2, BIRC5, PARP1, BCL2, BCL2L1
37	thalidomide32 42 9 9	14.8	VTN, VEGFA, BIRC2, BIRC3, BIRC5, BCL2L1
38	prostaglandin32	11.7	VEGFC, MT-CO2, CDK4, MMP1, MMP3, MMP7
39	parthenolide32	11.4	PIK3CG, BID, BIRC3, BCL2L1, CHUK, MMP9
40	suramin32 9 9	13.2	PCNA, VEGFA, BMP6, P2RX7, CDK2, FOS
41	prostacyclin32	11.1	VTN, SERPINC1, SERPINE1, VEGFA, BMP6, LEP
42	polyethylene glycol32	11.0	VTN, SERPINC1, MUC1, AZGP1, MPO, CDH1
43	dihydrotestosterone32 9 18 9	13.8	SETD2, SERPINE1, BMP6, CLU, LEP, CDK2
44	manumycin32	10.8	CHUK, INSR, ANXA5, MAPK8, MAPK14, HRAS
45	ivig32	10.6	IL18R1, IL3, FASLG, CCR5, CRP, LTA
46	15-deoxy-delta-12,14-prostaglandin j232	10.6	PIK3CG, SERPINE1, VEGFA, MYC, BMP6, BIRC2
47	l-nmma32	10.4	INSR, IL1RN, CAT, PPARG, NOS2, COX5A
48	mifepristone32 42 9 9	13.2	BIRC5, ZFP36, BCL2L1, MUC1, BAX, CGB
49	go 697632 42	11.0	PIK3CG, CDK1, CDH1, MMP2, IL8, MAPK8
50	ang ii32	9.9	PIK3CG, VEGFA, ANPEP, MAPK8, MAPK3, MAPK1

Cellular components related to cervical cancer according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	30.4	ZNF350, ZNF434, PIN1, NCL, RECQL4, RELA
2	cytoplasm	GO:005737	29.1	PIP5KL1, PIK3CG, PIN1, RECQL4, RELA, KIAA1524
3	cytosol	GO:005829	21.0	PIK3CA, PIK3CG, RELA, SFRP1, BUB3, NAT2
4	plasma membrane	GO:005886	19.9	PIK3CG, PDCD1, KIAA1524, SFRP1, PCDH10, SERPINC1
5	nucleoplasm	GO:005654	18.3	ZNF217, PIN1, RFC1, RELA, PCNA, RB1
6	extracellular region	GO:005576	16.2	VTN, SERPINC1, SERPINF1, SERPINA1, SERPINE1, SERPINA3
7	integral to plasma membrane	GO:005887	16.0	NCR1, NCR2, NCR3, SDC1, MUC1, LAMP1
8	extracellular space	GO:005615	15.0	VTN, SFN, SFRP1, SFRP2, PCOLCE, SERPINC1
9	membrane	GO:016020	13.6	PIP5KL1, PIK3CG, VEGFA, VEGFB, VEGFC, BID
10	cell surface	GO:009986	12.8	SFRP1, VEGFA, RARA, CD226, CD44, CDH1
11	external side of plasma membrane	GO:009897	12.0	LAMP1, P2RX7, CD28, CD86, CD244, CD83

Biological processes related to cervical cancer according to GeneDecks:

(show top 50)    (show all 76)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription from RNA polymerase II promoter	GO:000122	15.6	MYC, BMI1, RARB, ZFHX3, ZFP36, PARP1
2	virus-host interaction	GO:019048	15.3	RELA, RB1, RBL1, BNIP3, RAN, PACS1
3	positive regulation of transcription from RNA polymerase II promoter	GO:045944	14.7	RELA, SFRP2, RB1, RBL1, SERPINE1, BRCA1
4	negative regulation of transcription, DNA-dependent	GO:045892	14.7	ZNF350, ZNF217, RELA, SFRP1, SFRP2, RB1
5	signal transduction	GO:007165	14.2	NCR1, NCR2, PDCD1, SFN, VEGFC, RARA
6	negative regulation of apoptotic process	GO:043066	14.0	PIK3CG, RELA, SFRP1, SERPINE1, VEGFA, MYC
7	positive regulation of transcription, DNA-dependent	GO:045893	14.0	RELA, SFRP1, RB1, BRCA1, BRCA2, MYC
8	response to DNA damage stimulus	GO:006974	14.0	BRCA1, MYC, RASSF1, BCL2, BCL3, YY1
9	negative regulation of cell proliferation	GO:008285	14.0	SFN, SFRP1, SFRP2, RBBP4, RARB, RARRES3
10	DNA repair	GO:006281	13.6	RFC1, RECQL4, PCNA, BRCA1, BRCA2, PARP1
11	induction of apoptosis by intracellular signals	GO:008629	13.5	BNIP3, MYC, BID, CLU, BCL2, BCL2L1
12	cell cycle arrest	GO:007050	13.4	RB1, MYC, RASSF1, ZAK, BARD1, MSH2
13	cytokine-mediated signaling pathway	GO:019221	13.3	PIN1, RELA, CD44, IRF1, IRF3, IL13RA2
14	cell proliferation	GO:008283	13.3	SFN, PCNA, SERPINF1, PAX1, BCL2L1, UHRF1
15	immune response	GO:006955	13.3	NCR3, VTN, SERPINB4, BMP6, CHUK, AZGP1
16	response to organic cyclic compound	GO:014070	13.2	SFRP1, SERPINA1, BAK1, P2RX7, MSH2, JUN
17	innate immune response	GO:045087	13.1	PIK3CG, PIN1, RELA, CLU, BCL2, BCL2L1
18	positive regulation of cell proliferation	GO:008284	13.1	SFRP1, SFRP2, VEGFA, VEGFC, MYC, RARA
19	anti-apoptosis	GO:006916	13.0	PIK3CA, RELA, VEGFB, BNIP3, BIRC2, BIRC3
20	positive regulation of apoptotic process	GO:043065	13.0	SFRP1, SFRP2, RARB, BID, CLU, ZBTB16
21	angiogenesis	GO:001525	12.7	PIK3CA, PIK3CG, NCL, SETD2, SERPINE1, VEGFA
22	response to lipopolysaccharide	GO:032496	12.6	SERPINA1, S100A8, S100A9, P2RX7, JUN, MMP9
23	blood coagulation	GO:007596	12.4	PIK3CA, PIK3CG, SERPINC1, SERPINA1, SERPINE1, BSG
24	positive regulation of cell migration	GO:030335	12.3	VEGFA, MYLK, CDH13, ITGAV, ITGB1, MMP14
25	cell surface receptor signaling pathway	GO:007166	12.2	BSG, BIRC2, BIRC3, BAG1, P2RX7, CD28
26	interferon-gamma-mediated signaling pathway	GO:060333	12.2	CD44, IRF1, IRF3, IFNG, IFNGR2, ICAM1
27	release of cytochrome c from mitochondria	GO:001836	12.1	SFN, MYC, BID, CLU, BCL2, BCL2L1
28	positive regulation of neuron apoptotic process	GO:043525	12.0	BAG1, BAX, ATM, JUN, CDK5, ITGA1
29	positive regulation of ERK1 and ERK2 cascade	GO:070374	12.0	VEGFB, CD44, MIF, ARHGAP8, FGF10, FGF2
30	leukocyte migration	GO:050900	12.0	PIK3CA, BSG, CD58, CD244, ITGA3, ITGA5
31	response to hypoxia	GO:001666	12.0	SERPINA1, VEGFA, BNIP3, BCL2, LEP, XRCC1
32	cell-cell signaling	GO:007267	12.0	SFRP2, S100A9, CGB, CD86, CD80, CD97
33	cellular response to mechanical stimulus	GO:071260	11.9	BNIP3, BAK1, ITGB1, IRF1, IL13, IL18
34	inflammatory response	GO:006954	11.8	PIK3CG, NCR3, RELA, SERPINA3, BMP6, PARK7
35	phosphatidylinositol-mediated signaling	GO:048015	11.5	PIK3CA, PCNA, CHUK, UBE2C, MTOR, AURKA
36	positive regulation of protein phosphorylation	GO:001934	11.5	PIN1, VEGFA, MTOR, ITGB3, INSR, IL1B
37	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.3	VTN, VEGFA, VEGFB, MTOR, CD80, CD44
38	response to ethanol	GO:045471	11.3	BCL2, BAK1, S100A8, S100A9, CDK1, MMP9
39	aging	GO:007568	11.3	SERPINF1, BAK1, JUN, GRB2, IL15, IL1B
40	response to mechanical stimulus	GO:009612	11.2	P2RX7, JUN, JUNB, MMP9, FOSL1, ANGPT2
41	positive regulation of protein kinase B signaling cascade	GO:051897	11.1	PIK3CG, VEGFB, MTOR, INSR, ANGPT1, CCR7
42	MAPK cascade	GO:000165	11.1	MYC, CDK1, FGFR1, FGFR3, IL18, IL1B
43	fibroblast growth factor receptor signaling pathway	GO:008543	11.1	PIK3CA, CHUK, MTOR, CDKN1B, CDK1, FGF10
44	epidermal growth factor receptor signaling pathway	GO:007173	11.0	PIK3CA, CHUK, MTOR, CDKN1B, CDK1, GRB2
45	response to estradiol stimulus	GO:032355	10.6	SERPINA1, BRCA2, RARA, BID, AURKA, MMP9
46	positive regulation of mitosis	GO:045840	10.5	AURKA, CD28, INSR, MET, IL1A, IL1B
47	lipopolysaccharide-mediated signaling pathway	GO:031663	10.0	IRF3, IL18, IL1B, MAPK3, MAPK14, CCL2
48	apoptotic process	GO:006915	INF	PDCD1, SFN, BRCA1, BNIP3, BLCAP, BID
49	induction of apoptosis	GO:006917	INF	BNIP3, BAX, CDKN1B, CDKN2A, IRF1, IRF3
50	response to drug	GO:042493	INF	SFRP1, SFRP2, VEGFC, MYC, PARK7, BCL2

Molecular functions related to cervical cancer according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	38.1	RPSA, KRT14, LTF, KPNA2, KPNB1, NDRG2
2	ATP binding	GO:005524	16.9	PKM, RPS6KB1, PLK1, OAS3, SRC, RNASEL
3	protein homodimerization activity	GO:042803	14.7	PDK2, ABCG2, ACAT1, HES1, HEXB, PDGFRA
4	transcription factor binding	GO:008134	13.8	HIF1A, HES2, HES1, NFKBIA, CREBBP, SMAD2
5	protein heterodimerization activity	GO:046982	13.5	HEXB, HEXA, EGFR, PDK2, CYBA, TP53
6	identical protein binding	GO:042802	13.4	TNF, TP73, TP63, TP53, ERBB2, ESR1
7	protein kinase activity	GO:004672	11.6	PDK2, RNASEL, RPS6KB1, PLK1, SRC, EIF2AK3
8	growth factor activity	GO:008083	11.4	IL12B, TGFA, TGFB1, DKK1, CXCL12, NUDT6
9	cytokine activity	GO:005125	11.3	VEGFA, BMP6, MIF, INHBA, INHBB, FGF2
10	enzyme binding	GO:019899	11.3	HIF1A, ACAT1, EGFR, WWOX, NFKBIA, NOTCH1
11	heparin binding	GO:008201	11.2	CCL2, CCL5, PTN, CTGF, NRP1, LTF
12	transcription regulatory region DNA binding	GO:044212	11.1	TP73, TNF, CTNNB1, PPARG, SMAD4, SMAD7