MCID: CRV035
MIFTS: 54

Cervical Cancer malady

Cancer category

Summaries for Cervical Cancer

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. cervical cancer is caused by a virus called hpv. the virus spreads through sexual contact. most women's bodies are able to fight hpv infection. but sometimes the virus leads to cancer. you're at higher risk if you smoke, have many children, use birth control pills for a long time, or have hiv infection. cervical cancer may not cause any symptoms at first. later, you may have pelvic pain or bleeding from the vagina. it usually takes several years for normal cells in the cervix to turn into cancer cells. your health care provider can find abnormal cells by doing a pap test - examining cells from the cervix under a microscope. if there are abnormal cells, you will need a biopsy. by getting regular pap tests and pelvic exams you can find and treat any problems before they turn into cancer. treatment may include surgery, radiation therapy, chemotherapy, or a combination. the choice of treatment depends on the size of the tumor, whether the cancer has spread and whether you would like to become pregnant someday. vaccines can protect against several types of hpv, including some that can cause cancer. nih: national cancer institute

MalaCards: Cervical Cancer, also known as cervical carcinoma, is related to cervical intraepithelial neoplasia and thyroid cancer. An important gene associated with Cervical Cancer is ST3 (suppression of tumorigenicity 3), and among its related pathways are Pathways in cancer and VEGFR3 signaling in lymphatic endothelium. Affiliated tissues include the cervix uteri or.

Disease Ontology:8 A cervix uteri cancer that is located in the cervix uteri or located in the cervical area.

CDC:3 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

Wikipedia:64 Cervical cancer is a malignant neoplasm arising from cells originating in the cervix uteri. One of the... more...

Description from OMIM:47 603956

Aliases & Classifications for Cervical Cancer

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 47OMIM, 22GTR, 40NCIt, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

cervical cancer 8 10 45 34
cervical carcinoma 8 47 45
carcinoma of cervix 8 22
cervix carcinoma 8 61
carcinoma of the cervix uteri 8
neoplasm of uterine cervix 8
uterine cervical neoplasm 61
tumor of the cervix uteri 8
carcinoma cervix uteri 8
malignant neoplasms 61
cervix uteri cancer 8
neoplasms cervical 45
cervical neoplasm 8
cancer of cervix 8
cervix cancer 8


Related Diseases for Cervical Cancer

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cervical Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 361)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia31.2VEGFC
2thyroid cancer29.8VEGFC, FGFR3, PIK3CA
3squamous cell carcinoma10.6
4vascular cancer10.6
5hypoxia10.6
6tongue cancer10.6
7nasopharynx carcinoma10.5
8adenoid cystic carcinoma10.5
9cervical adenoid cystic carcinoma10.5
10rare squamous cell carcinoma of the cervix uteri10.5
11glassy cell carcinoma of the cervix uteri10.5
12adenoid basal carcinoma of the cervix uteri10.5
13papillary carcinoma of the cervix uteri10.5
14malignant müllerian mixed tumor of the cervix uteri10.5
15malignant peripheral neuroectodermal tumor of the cervix uteri10.5
16malignant germ cell tumor of the cervix uteri10.5
17vaginal cancer10.4
18adenocarcinoma10.4
19n syndrome10.3
20cystic basal cell carcinoma10.3
21adenoid squamous cell carcinoma10.3
22adenoid basal cell carcinoma10.3
23cervical clear cell adenocarcinoma10.3
24verrucous carcinoma10.3
25radiation induced cancer10.3
26epiglottis cancer10.3
27acute lymphoblastic leukemia, childhood10.3
28intrahepatic gall duct cancer10.3
29colorectal cancer10.2
30cheek mucosa cancer10.2
31tonsil cancer10.2
32malignant neoplasm of short bones of lower limb10.2
33round ligament malignant neoplasm10.2
34brain stem neoplasm10.2
35myoma10.2
36trachoma10.2
37adenosquamous carcinoma10.2
38cervical cancer, somatic10.2
39parathyroid carcinoma10.1
40pancreatic endocrine carcinoma10.1
41spinal meninges cancer10.1
42malignant tumor of undescended testis10.1
43splenic flexure cancer10.1
44pancreatic ductal carcinoma10.1
45mandibular cancer10.1
46broad ligament malignant neoplasm10.1
47chest wall lymphoma10.1
48myositis ossificans10.1
49actinomycosis10.1
50tonsillar pillar cancer10.1

Graphical network of the top 20 diseases related to Cervical Cancer:



Diseases related to cervical cancer

Clinical Features for Cervical Cancer

Sources:
47OMIM
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Clinical features from OMIM:

603956

Drugs & Therapeutics for Cervical Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cervical Cancer

Drug clinical trials:

Search ClinicalTrials for Cervical Cancer

Search NIH Clinical Center for Cervical Cancer

Search CenterWatch for Cervical Cancer

Genetic Tests for Cervical Cancer

Sources:
22GTR
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Genetic tests related to Cervical Cancer:

id Genetic test Affiliating Genes
1 Carcinoma Of Cervix22

Anatomical Context for Cervical Cancer

Sources:
14FMA
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FMA organs/tissues related to Cervical Cancer:

14
The cervix uteri or

Animal Models for Cervical Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Cervical Cancer

Sources:
51PubMed
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Articles related to Cervical Cancer:

(show top 50)    (show all 2049)
idTitleAuthorsYear
1
Lymphadenectomy in Locally Advanced Cervical Cancer Study (LiLACS): Phase III Clinical Trial Comparing Surgical With Radiologic Staging in Patients With Stages IB2-IVA Cervical Cancer. (23911560)
2014
2
Cytotoxic function of gamma delta (gamma/delta) T cells against pamidronate-treated cervical cancer cells. (24228383)
2013
3
Human papillomavirus genotypes and cervical cancer in northeast Thailand. (24377633)
2013
4
Pathological response on surgical samples is an independent prognostic variable for patients with Stage Ib2-IIb cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy: an Italian multicenter retrospective study (CTF Study). (24096111)
2013
5
Cost-effectiveness of Korea's National Cervical Cancer Screening Program. (23991998)
2013
6
Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells. (24113164)
2013
7
MicroRNA-361-5p facilitates cervical cancer progression through mediation of epithelial-to-mesenchymal transition. (24158756)
2013
8
Evaluating PET-CT in routine surveillance and follow-up after treatment for cervical cancer: a cost-effectiveness analysis. (24299112)
2013
9
Effects of treatment duration during concomitant chemoradiation therapy for cervical cancer. In regard to Shaverdian et al. (24138909)
2013
10
Decision-making about cervical cancer screening methods by homeless women. (24218868)
2013
11
Pain assessment during conscious sedation for cervical cancer high-dose-rate brachytherapy. (23904769)
2013
12
Screening for breast and cervical cancer: understanding the different recommendations. (23957799)
2013
13
Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation. (23954443)
2013
14
Cervical cancer screening: knowledge, attitude and practices among nursing staff in a tertiary level teaching institution of rural India. (23886159)
2013
15
Effectiveness of cervical cancer screening based on a mathematical screening model using data from the Hiroshima Prefecture Cancer Registry. (24083688)
2013
16
Results of pap smears and immunocytochemical detection of the p16 and Ki67 proteins in women with cervical intraepithelial neoplasia and cervical cancer]. (23379189)
2012
17
Altered expression levels of HLA class a8! and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer. (22965188)
2012
18
Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population. (22228261)
2012
19
Contribution of retinoblastoma LOH and the p53 Arg/Pro polymorphism to cervical cancer. (22692183)
2012
20
Performance of p16/Ki-67 immunostaining to detect cervical cancer precursors in a colposcopy referral population. (22675168)
2012
21
Cervical and breast cancer-screening knowledge of women with developmental disabilities. (22642963)
2012
22
Membranous expression of ectodomain isoforms of the epidermal growth factor receptor predicts outcome after chemoradiotherapy of lymph node-negative cervical cancer. (21737508)
2011
23
Immunolabeling of the inhibin-I^A and -I^B subunit in normal and malignant human cervical tissue and cervical cancer cell lines. (21475087)
2010
24
Requirement of T-lymphokine-activated killer cell-originated protein kinase for TRAIL resistance of human HeLa cervical cancer cells. (19945431)
2010
25
Novel missense mutation in FHIT gene: interpreting the effect in HPV-mediated cervical cancer in Indian women. (19730990)
2010
26
The expression of APE1 and its correlation with prognostic significance after 252Cf radiotherapy in cervical cancer]. (19292061)
2009
27
Significance of nuclear hTra2-beta1 expression in cervical cancer. (19037821)
2009
28
Aspirin Has Antitumor Effects via Expression of Calpain Gene in Cervical Cancer Cells. (19266085)
2008
29
p16INK4 expression in precursor lesions of squamous cell cervical cancer related to the presence of HPV-DNA. (18719739)
2008
30
Co-expression of HSV2 and Chlamydia trachomatis in HPV-positive cervical cancer and cervical intraepithelial neoplasia lesions is associated with aberrations in key intracellular pathways. (18812695)
2008
31
Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival. (18425078)
2008
32
The value of tumor marker and cytokine analysis for the assessment of regional lymph node status in cervical cancer patients. (18217970)
2008
33
FAS -1377 G/A polymorphism and the risk of lymph node metastasis in cervical cancer. (18068525)
2008
34
Expression of CC chemokine receptor 7 in tonsillar cancer predicts cervical nodal metastasis, systemic relapse and survival. (17687340)
2007
35
Expression of class III beta tubulin in cervical cancer patients administered preoperative radiochemotherapy: correlation with response to treatment and clinical outcome. (17030352)
2007
36
Is the p53 codon 72 polymorphism a key biomarker for cervical cancer development? A meta-analysis review within European populations. (17912468)
2007
37
No association between SNP309 promoter polymorphism in the MDM2 and cervical cancer in a study from northeastern Brazil. (18023538)
2007
38
Expression of high-abundance proteins in sera of patients with endometrial and cervical cancers: analysis using 2-DE with silver staining and lectin detection methods. (17503403)
2007
39
Phosphatidylinositol 3-kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines. (16397049)
2006
40
Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer. (15923164)
2005
41
Proteomic analysis of progressive factors in uterine cervical cancer. (15838902)
2005
42
Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines. (15878915)
2005
43
Ribozyme targeting HPV16 E6E7 transcripts in cervical cancer cells suppresses cell growth and sensitizes cells to chemotherapy and radiotherapy. (15467442)
2004
44
Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer. (14504050)
2003
45
TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer risk. (12648582)
2003
46
KCl cotransport is an important modulator of human cervical cancer growth and invasion. (12902337)
2003
47
Enhanced expression of thymidylate synthase mediates resistance of uterine cervical cancer cells to radiation. (12239455)
2002
48
p53 polymorphism and human papillomavirus infection in Hong Kong women with cervical cancer. (10895031)
2000
49
A 2-week pretreatment with 13-cis-retinoic acid + interferon-alpha-2a prior to definitive radiation improves tumor tissue oxygenation in cervical cancers. (9830438)
1998
50
Prognostic value of cytokeratins and carcinoembryonic antigen expression in primary surgically treated cervical cancer. (7516638)
1994

Genetic Variations for Cervical Cancer

Expression for genes affiliated with Cervical Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cervical Cancer

Search GEO for disease gene expression data for Cervical Cancer.

Pathways for genes affiliated with Cervical Cancer

Sources:
30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Cervical Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2WNT6, FGFR3, VEGFC, PIK3CA
210.8VEGFC, PIK3CA

Compounds for genes affiliated with Cervical Cancer

GO Terms for genes affiliated with Cervical Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Cervical Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:00150111.0PAX1, FGFR3, HEXB
2bone morphogenesisGO:06034910.5PAX1, FGFR3

Products for genes affiliated with Cervical Cancer

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  • Proteins
  • Lysates
  • Antibodies

Sources for Cervical Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet