MCID: CRV047
MIFTS: 22

Cervical Cancer, Somatic malady

Genetic diseases (common), Cancer diseases categories
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Summaries for Cervical Cancer, Somatic

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MalaCards based summary: Cervical Cancer, Somatic is related to bladder carcinoma in situ and papilloma, and has symptoms including An important gene associated with Cervical Cancer, Somatic is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The compounds melphalan and bortezomib have been mentioned in the context of this disorder. Related mouse phenotypes are craniofacial and limbs/digits/tail.

Description from OMIM:46 603956

Aliases & Classifications for Cervical Cancer, Somatic

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Cervical Cancer, Somatic, Aliases & Descriptions:

Name: Cervical Cancer, Somatic 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases


Related Diseases for Cervical Cancer, Somatic

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Diseases related to Cervical Cancer, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma in situ10.0TP53, FGFR3
2papilloma10.0TP53, FGFR3
3transitional cell carcinoma10.0TP53, FGFR3
4multiple myeloma10.0TP53, FGFR3
5cervical cancer10.0FGFR3, TP53
6bladder carcinoma10.0TP53, FGFR3
7retinoblastoma10.0TP53, FGFR3
8stomach cancer9.9TP53, FGFR3
9burkitt's lymphoma9.9FGFR3, TP53
10colorectal cancer9.9FGFR3, TP53
11tongue squamous cell carcinoma9.9TP53, FGFR3
12leukemia9.9FGFR3, TP53
13melanoma9.8TP53, FGFR3
14prostate cancer9.8TP53, FGFR3

Graphical network of diseases related to Cervical Cancer, Somatic:



Diseases related to cervical cancer, somatic

Symptoms for Cervical Cancer, Somatic

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Clinical features from OMIM:

603956

HPO human phenotypes related to Cervical Cancer, Somatic:

id Description Frequency HPO Source Accession
1 neoplasm HP:0002664
2 abnormality of the cervical spine HP:0003319

Drugs & Therapeutics for Cervical Cancer, Somatic

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Drug clinical trials:

Search ClinicalTrials for Cervical Cancer, Somatic

Search NIH Clinical Center for Cervical Cancer, Somatic

Genetic Tests for Cervical Cancer, Somatic

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Anatomical Context for Cervical Cancer, Somatic

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Animal Models for Cervical Cancer, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Cervical Cancer, Somatic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.1FGFR3, TP53
2MP:00053719.0FGFR3, TP53
3MP:00020068.8FGFR3, TP53

Publications for Cervical Cancer, Somatic

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Variations for Cervical Cancer, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Cervical Cancer, Somatic:

64
id Symbol AA change Variation ID SNP ID
1FGFR3p.Ser249CysVAR_004149

Clinvar genetic disease variations for Cervical Cancer, Somatic:

6
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.747G> T (p.Arg249Ser)single nucleotide variantPathogenicrs28934571GRCh37Chr 17, 7577534: 7577534
2FGFR3NM_000142.4(FGFR3): c.746C> G (p.Ser249Cys)single nucleotide variantPathogenicrs121913483GRCh37Chr 4, 1803568: 1803568

Expression for genes affiliated with Cervical Cancer, Somatic

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Expression patterns in normal tissues for genes affiliated with Cervical Cancer, Somatic

Search GEO for disease gene expression data for Cervical Cancer, Somatic.

Pathways for genes affiliated with Cervical Cancer, Somatic

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Pathways related to Cervical Cancer, Somatic according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1FGFR3, TP53
2
Show member pathways
9.1FGFR3, TP53
3
Show member pathways
9.1FGFR3, TP53
4
Show member pathways
9.1TP53, FGFR3
5
Show member pathways
9.1TP53, FGFR3
6
Show member pathways
9.1TP53, FGFR3
7
Show member pathways
9.1FGFR3, TP53
89.1FGFR3, TP53
9
Show member pathways
Signaling Pathways in Glioblastoma37
9.1TP53, FGFR3
10
Show member pathways
9.1FGFR3, TP53
11
Show member pathways
MAPK signaling pathway37
9.1TP53, FGFR3
129.1TP53, FGFR3
13
Show member pathways
9.1TP53, FGFR3
149.1FGFR3, TP53
159.1TP53, FGFR3

Compounds for genes affiliated with Cervical Cancer, Somatic

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Cervical Cancer, Somatic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1melphalan44 50 1111.3TP53, FGFR3
2bortezomib44 50 1111.3FGFR3, TP53
3guanine44 24 1111.2TP53, FGFR3
4doxorubicin44 50 1111.2TP53, FGFR3
5paraffin449.1FGFR3, TP53
6arginine449.1TP53, FGFR3
7oligonucleotide449.0TP53, FGFR3
8vegf448.8TP53, FGFR3

GO Terms for genes affiliated with Cervical Cancer, Somatic

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Cellular components related to Cervical Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:0057839.1FGFR3, TP53

Biological processes related to Cervical Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:0001229.1FGFR3, TP53
2positive regulation of neuron apoptotic processGO:0435258.8FGFR3, TP53

Products for genes affiliated with Cervical Cancer, Somatic

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  • Antibodies
  • Proteins
  • Lysates

Sources for Cervical Cancer, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet