MCID: CRV036
MIFTS: 41

Cervical Carcinosarcoma malady

Category: Cancer diseases

Aliases & Classifications for Cervical Carcinosarcoma

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Aliases & Descriptions for Cervical Carcinosarcoma:

Name: Cervical Carcinosarcoma 10 12 65
Cervical Malignant Mixed Mesodermal Mullerian Tumor 10
 
Cervical Mixed Epithelial and Mesenchymal Neoplasm 10
Cervical Malignant Mixed Mullerian Tumor 10

Classifications:



External Ids:

Disease Ontology10 DOID:4112
UMLS65 C1332917, C1516420, C1518168

Summaries for Cervical Carcinosarcoma

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MalaCards based summary: Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to uterine ligament serous adenocarcinoma and benign multicystic peritoneal mesothelioma. An important gene associated with Cervical Carcinosarcoma is BCL2 (B-Cell CLL/Lymphoma 2), and among its related pathways are TP53 network and Aurora A signaling. Affiliated tissues include breast, kidney and prostate, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Related Diseases for Cervical Carcinosarcoma

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Diseases related to Cervical Carcinosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1uterine ligament serous adenocarcinoma10.6BCL2, BIRC5
2benign multicystic peritoneal mesothelioma10.6BCL2, PGR
3small intestine leiomyoma10.5BCL2, MME
4subungual glomus tumor10.5BCL2, TP53
5urethra inverted papilloma10.5BIRC5, TP53
6fallopian tube teratoma10.5BCL2, TP53
7secretory meningioma10.5BIRC5, PGR
8malignant renovascular hypertension10.5MME, PGR
9breast papillomatosis10.5MME, PGR
10caroli disease10.5BCL2, TP53
11transverse colon cancer10.5MME, PGR
12external ear squamous cell carcinoma10.4MAPK8IP1, TP53
13adult mesoblastic nephroma10.4MME, PGR
14dermato-cardio-skeletal syndrome, borrone type10.4BIRC5, TP53
15soft tissue sarcoma childhood10.4BCL2, TP53
16eccrine acrospiroma10.4MME, PGR
17female reproductive organ cancer10.4MME, PGR
18metachronous kidney wilms' tumor10.4PGR, TP53
19lip cancer10.4GP6, TP53
20deep leiomyoma10.4PGR, TP53
21ovary neuroendocrine neoplasm10.4PGR, TP53
22ovarian mesodermal adenosarcoma10.3PGR, TP53
23pituitary stalk meningioma10.3PGR, TP53
24cystadenoma10.3PGR, TP53
25superficial basal cell carcinoma10.3MME, TP53
26benign breast phyllodes tumor10.3ESR1, MME
27corneal neovascularization10.3PGR, TP53
28pyelonephritis10.3PGR, TP53
29nerve compression syndrome10.3ESR1, MME
30skull base meningioma10.3PGR, TP53
31lipomatosis10.3BIRC5, TP53
32syringoma10.3ESR1, PGR
33endocrine organ benign neoplasm10.3ESR1, PGR
34cervical benign neoplasm10.3ESR1, PGR
35large bowel leiomyoma10.3ESR1, PGR
36bile duct cystadenoma10.3ESR1, PGR
37glaucoma iridogoniodysgenesia10.3ESR1, PGR
38hypolipoproteinemia10.3MAPK8IP1, MAPK8IP2
39venous tributary occlusion of retina10.3ESR1, PGR
40deafness, autosomal dominant 8/1210.3ESR1, PGR
41peroneal nerve paralysis10.3ESR1, PGR
42situs inversus10.3ESR1, PGR
43vulvar squamous papilloma10.3ESR1, PGR
44childhood choriocarcinoma of the ovary10.3ESR1, PGR
45extragonadal nonseminomatous germ cell tumor10.3ESR1, PGR
46esophageal adenoid cystic carcinoma10.3ESR1, PGR
47seminal vesicle adenocarcinoma10.3ESR1, MME
48ureter adenocarcinoma10.3ESR1, PGR
49dental pulp calcification10.3ESR1, PGR
50spondylitis10.3ESR1, PGR

Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to cervical carcinosarcoma

Symptoms for Cervical Carcinosarcoma

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Drugs & Therapeutics for Cervical Carcinosarcoma

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Drugs for Cervical Carcinosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Doxorubicinapproved, investigationalPhase 1, Phase 2158223214-92-831703
Synonyms:
(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
(8S-cis)-10-((3-amino-2,3,6-Trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
111266-55-8
14-Hydroxydaunomycin
14-Hydroxydaunorubicine
14-hydroxydaunomycin
14-hydroxydaunorubicine
23214-92-8
23257-17-2
24385-08-8
25311-50-6
25316-40-9
25316-40-9 (hydrochloride)
29042-30-6
AC1L1M5T
AC1Q29OJ
ADM
ADR
Adriablastin
Adriacin (hydrochloride salt)
Adriamycin
Adriamycin PFS
Adriamycin PFS (hydrochloride salt)
Adriamycin RDF
Adriamycin RDF (hydrochloride salt)
Adriamycin Semiquinone
Adriamycin semiquinone
Adriblas tina
Adriblastin
Adriblastina
Adriblastina (TN)
Adriblastina (hydrochloride salt)
Aerosolized Doxorubicin
BPBio1_000502
BRD-K92093830-003-04-3
BSPBio_000456
BSPBio_001031
C01661
C27H29NO11
CCRIS 739
CHEBI:28748
CHEMBL179
CID31703
Caelyx
Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74
Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120
D03899
DB00997
DM2
DOX-SL
Doxil
Doxo
Doxorubicin
Doxorubicin (USAN/INN)
Doxorubicin HCl
 
Doxorubicin Hydrochloride
Doxorubicin [USAN:INN:BAN]
Doxorubicin citrate
Doxorubicin hydrochloride (hydrochloride salt)
Doxorubicin-P4/D10
Doxorubicin-P4/D10 conjugate
Doxorubicin-hLL1
Doxorubicin-hLL1 conjugate
Doxorubicina
Doxorubicina [INN-Spanish]
Doxorubicine
Doxorubicine [INN-French]
Doxorubicinum
Doxorubicinum [INN-Latin]
EINECS 245-495-6
FI 106
Farmablastina (hydrochloride salt)
HMS2089H06
HSDB 3070
Hydroxydaunomycin hydrochlor ide (hydrochloride salt)
Hydroxydaunomycin hydrochloride (hydrochloride salt)
Hydroxydaunorubicin
Hydroxydaunorubicin hydrochloride (hydrochloride salt)
JT9100000
LMPK13050001
LS-1029
LS-165655
MLS000759533
Myocet
NCI-C01514
NChemBio.2007.10-comp13
NDC 38242-874
NIOSH/JT9100000
NSC 123127
Prestwick0_000438
Prestwick1_000438
Prestwick2_000438
Prestwick3_000438
Probes1_000151
Probes2_000129
RDF Rubex
Resmycin
Rubex
Rubex (hydrochloride salt)
SMP1_000106
SPBio_002395
TLC D-99
ThermoDox
Triferric doxorubicin
UNII-80168379AG
adiblastine (hydrochloride salt)
adr iablatina (hydrochloride salt)
adriablastine (hydrochloride salt)
adriablatina (hydrochloride salt)
adriblatina (hydrochloride salt)
doxorubicin
nchembio809-comp5
2
CarboplatinapprovedPhase 1, Phase 2188541575-94-410339178, 498142, 38904
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)
3
DoxilApproved June 1999Phase 1, Phase 2158231703
Synonyms:
Dox-SL
Doxil
 
Evacet
LipoDox
Pegylated Liposomal Doxorubicin Hydrochloride
liposomal doxorubicin
4Anti-Bacterial AgentsPhase 1, Phase 29140
5Topoisomerase InhibitorsPhase 1, Phase 24081
6Antibiotics, AntitubercularPhase 1, Phase 25971
7RadiopharmaceuticalsPhase 1, Phase 2362
8Fluorodeoxyglucose F18Phase 1, Phase 2356
9
FluorouracilapprovedPhase 1168451-21-83385
Synonyms:
1-fluoro-1h-pyrimidine-2,4-dione
1004-03-1
1upf
2,4-Dihydroxy-5-fluoropyrimidine
2,4-Dioxo-5-fluoropryimidine
2,4-Dioxo-5-fluoropyrimidine
47576_FLUKA
4921-97-5
5 FU Lederle
5 FU medac
5 Fluorouracil
5 Fluorouracil biosyn
5 HU Hexal
5-FU
5-FU (TN)
5-FU Lederle
5-FU medac
5-Faracil
5-Fluor-2,4(1H,3H)-pyrimidindion
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-dihydroxypyrimidin [Czech]
5-Fluor-2,4-pyrimidindiol
5-Fluor-2,4-pyrimidindiol [Czech]
5-Fluoracil
5-Fluoracil [German]
5-Fluoracyl
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4-pyrimidinedione
5-Fluoropyrimidin-2,4-diol
5-Fluoropyrimidine-2,4-dione
5-Fluorouracil
5-Fluorouracil-biosyn
5-Fluoruracil
5-Fluoruracil [German]
5-Fluracil
5-Ftouracyl
5-HU Hexal
5-fluoro uracil
5-fluoro-1H-pyrimidine-2,4-dione
5-fluoropyrimidine-2,4(1H,3H)-dione
5-fluorouracil
51-21-8
5FU
79108-01-3
AC-11201
AC1L1FTE
AC1Q4N2X
AI3-25297
AKOS000119162
AKOS003237897
AccuSite
Actino-Hermal
Adrucil
Adrucil (TN)
Allergan Brand of Fluorouracil
Arumel
BB_NC-0576
BSPBio_002048
C07649
C4H3FN2O2
CCRIS 2582
CHEBI:46345
CHEMBL185
CID3385
CPD0-1327
CPD000038082
CSP Brand of Fluorouracil
Carac
Carac (TN)
Carzonal
Cinco FU
Cytosafe
D005472
D00584
DB00544
Dakota Brand of Fluorouracil
Dakota, Fluorouracile
Dermatech Brand of Fluorouracil
Dermik Brand of Fluorouracil
DivK1c_000054
EINECS 200-085-6
EU-0100536
Effluderm
Effluderm (free base)
Efudex
Efudix
Efurix
F 6627
F0151
F6627_SIGMA
F8423_SIGMA
FT-0082524
FU
Ferrer Brand of Fluorouracil
Fiverocil
Fluoro Uracil
Fluoro Uracile ICN
Fluoro-Uracile ICN
Fluoro-uracile
Fluoro-uracilo
Fluoroblastin
Fluoroplex
Fluoroplex (TN)
Fluorouracil
Fluorouracil (JP15/USP/INN)
Fluorouracil GRY
Fluorouracil Mononitrate
Fluorouracil Monopotassium Salt
Fluorouracil Monosodium Salt
Fluorouracil Potassium Salt
Fluorouracil Teva Brand
Fluorouracil [USAN:INN:BAN:JAN]
 
Fluorouracil-GRY
Fluorouracile
Fluorouracile Dakota
Fluorouracile [DCIT]
Fluorouracilo
Fluorouracilo Ferrer Far
Fluorouracilo [INN-Spanish]
Fluorouracilum
Fluorouracilum [INN-Latin]
Fluoruracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluracilum
Fluri
Fluril
Fluro Uracil
Fluroblastin
Flurodex
Flurouracil
Flurox
Ftoruracil
Gry Brand of Fluorouracil
HMS1920O18
HMS2090I04
HMS2091F19
HMS500C16
HSDB 3228
Haemato Brand of Fluorouracil
Haemato fu
Haemato-fu
Hexal Brand of Fluorouracil
I07-0022
ICN Brand of Fluorouracil
IDI1_000054
IN1335
KBio1_000054
KBio2_001321
KBio2_003889
KBio2_006457
KBio3_001268
KBioGR_001253
KBioSS_001321
Kecimeton
LS-153
Lopac-F-6627
Lopac0_000536
MLS000069498
MLS002415705
MolPort-000-156-102
MolPort-003-990-447
MolPort-004-758-143
MolPort-004-758-144
MolPort-005-861-486
NCGC00015442-01
NCGC00015442-03
NCGC00015442-10
NCGC00091349-01
NCGC00091349-02
NCGC00091349-03
NCGC00091349-04
NCGC00091349-05
NCGC00091349-07
NCGC00091349-08
NCI60_001652
NINDS_000054
NSC 19893
NSC-19893
NSC19893
Neocorp Brand of Fluorouracil
Neofluor
Onkofluor
Onkoworks Brand of Fluorouracil
Phthoruracil
Phtoruracil
Queroplex
Ribofluor
Riemser Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
S1209_Selleck
SAM002264615
SMR000038082
SPBio_000291
SPECTRUM1500305
STK297802
Spectrum2_000076
Spectrum3_000434
Spectrum4_000557
Spectrum5_000718
Spectrum_000841
T5233394
TL8006093
Teva Brand of Fluorouracil
Timazin
U 8953
U-8953
UNII-U3P01618RT
UPCMLD-DP130
UPCMLD-DP130:001
URF
Ulup
WLN: T6MVMVJ EF
ZINC00897110
biosyn Brand of Fluorouracil
fluorouracil
inhibits thymilidate synthetase
medac Brand of Fluorouracil
nchembio.90-comp3
nchembio809-comp6
ribosepharm Brand of Fluorouracil
tetratogen
10
Belinostatapproved, investigationalPhase 141
Synonyms:
Beleodaq
 
Belinostat
PXD 101
11Antimetabolites, AntineoplasticPhase 15770
12AntimetabolitesPhase 19454
13Histone Deacetylase InhibitorsPhase 1532
14Immunosuppressive AgentsPhase 110422
15ImmunoglobulinsPhase 14477
16AntibodiesPhase 14477
17Antibodies, MonoclonalPhase 12413
18Immunologic FactorsPhase 118483
19AndrogensPhase 11162
20ImmunotoxinsPhase 170
21ColaNutraceutical1768

Interventional clinical trials:

idNameStatusNCT IDPhase
1Liposomal Doxorubicin and Carboplatin in Treating Patients With Gynecologic CancerCompletedNCT00032162Phase 1, Phase 2
2BI 2536 in Treating Patients With Recurrent or Metastatic Solid TumorsCompletedNCT00526149Phase 2
3Fludeoxyglucose F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial CancerActive, not recruitingNCT00416455Phase 1, Phase 2
4Immunotoxin Therapy in Treating Patients With Advanced CancerCompletedNCT00006981Phase 1
5Immunotoxin Therapy in Treating Patients With Advanced Solid TumorsCompletedNCT00066651Phase 1
6Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid TumorsCompletedNCT00413322Phase 1
7Suitability of DCE-MRI for Detection of Vascular Changes After VBTRecruitingNCT01991808Phase 1
8Study of Previously Collected and Stored Tissue Samples From Patients Previously Enrolled in a Completed National Cancer Institute Clinical TrialCompletedNCT00904514

Search NIH Clinical Center for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

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Anatomical Context for Cervical Carcinosarcoma

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MalaCards organs/tissues related to Cervical Carcinosarcoma:

33
Breast, Kidney, Prostate, Ovary, Small intestine, Thymus, Lymph node

Animal Models for Cervical Carcinosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Cervical Carcinosarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.7BCL2, BIRC5, ESR1, MAPK8IP1, MAPK8IP2, PGR
2MP:00053897.5BCL2, ESR1, GP6, MAPK8IP1, MAPK8IP2, PGR
3MP:00053877.5BCL2, BIRC5, ESR1, GP6, MME, PGR
4MP:00107686.7BCL2, BIRC5, ESR1, GP6, MAPK8IP1, MAPK8IP2
5MP:00053765.7BCL2, BIRC5, ESR1, GP5, GP6, MAPK8IP1

Publications for Cervical Carcinosarcoma

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Articles related to Cervical Carcinosarcoma:

idTitleAuthorsYear
1
Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study. (25400816)
2014
2
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. (23651629)
2013
3
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. (20668868)
2011
4
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. (21446343)
2011
5
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. (19263060)
2009
6
Cervical carcinosarcoma: a case report. (18357808)
2008
7
Case of uterine cervical carcinosarcoma. (16176508)
2005
8
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. (9441782)
1997
9
Cervical carcinosarcoma: a case report. (3957124)
1986

Variations for Cervical Carcinosarcoma

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Expression for genes affiliated with Cervical Carcinosarcoma

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Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for genes affiliated with Cervical Carcinosarcoma

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GO Terms for genes affiliated with Cervical Carcinosarcoma

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Biological processes related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of mitochondrial membrane permeabilityGO:004690210.2BCL2, TP53
2cellular response to glucose starvationGO:00421499.9BCL2, TP53
3cell agingGO:00075699.8BCL2, TP53
4response to gamma radiationGO:00103329.8BCL2, TP53
5behavioral fear responseGO:00016629.7BCL2, MAPK8IP2
6negative regulation of apoptotic processGO:00430668.7BCL2, BIRC5, MAPK8IP1, TP53

Molecular functions related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MAP-kinase scaffold activityGO:000507810.0MAPK8IP1, MAPK8IP2
2ubiquitin protein ligase bindingGO:00316259.7BCL2, TP53

Sources for Cervical Carcinosarcoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet