MCID: CRV036
MIFTS: 30

Cervical Carcinosarcoma malady

Cancer diseases category

Summaries for Cervical Carcinosarcoma

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32MalaCards
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MalaCards: Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to cervicitis and vaginal carcinosarcoma. An important gene associated with Cervical Carcinosarcoma is BIRC5 (baculoviral IAP repeat containing 5), and among its related pathways are Development PDGF signaling via STATs and NF-kB and Apoptosis and Autophagy. The compounds ponicidin and naphtho(1,2-b)furan-4,5-dione have been mentioned in the context of this disorder. Affiliated tissues include uterus.

Aliases & Classifications for Cervical Carcinosarcoma

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Sources:
8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical carcinosarcoma 8 60
cervical malignant mixed mesodermal mullerian tumor 8
cervical mixed epithelial and mesenchymal neoplasm 8
cervical malignant mixed mullerian tumor 8
malignant mixed mesodermal tumor 60


External Ids:

Disease Ontology8 DOID:4112
NCIt39 C36097

Related Diseases for Cervical Carcinosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Cervical Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis10.5
2vaginal carcinosarcoma10.4
3cervical wilms' tumor10.4
4uterine carcinosarcoma10.3
5adenosarcoma10.3
6cystic teratoma10.3
7fallopian tube carcinosarcoma10.3
8malignant teratoma10.3
9ovarian carcinosarcoma10.3
10malignant mixed mullerian tumor10.3
11cervical adenosarcoma10.0
12adenocarcinoma10.0
13cervical adenocarcinoma10.0
14cervical squamous cell carcinoma10.0
15squamous cell carcinoma10.0
16renal clear cell carcinoma10.0BIRC5
17cervical intraepithelial neoplasia10.0BIRC5
18colon adenocarcinoma10.0BCL2
19hepatoblastoma10.0BIRC5
20b-cell chronic lymphocytic leukemia10.0BCL2, BIRC5
21gastric adenocarcinoma10.0BIRC5, BCL2
22burkitt's lymphoma10.0BIRC5, BCL2
23non-small cell lung carcinoma10.0BCL2, BIRC5
24chronic lymphocytic leukemia10.0BCL2, BIRC5
25cervical cancer10.0BIRC5, BCL2
26squamous cell carcinoma of the head and neck10.0BCL2, BIRC5
27b-cell lymphomas10.0BCL2, BIRC5
28laryngeal benign neoplasm10.0BCL2, BIRC5
29t-cell leukemia10.0BIRC5, BCL2
30laryngeal squamous cell carcinoma10.0BIRC5, BCL2
31chronic myeloid leukemia10.0BIRC5, BCL2
32lung adenocarcinoma10.0BIRC5, BCL2
33non-hodgkin lymphoma10.0BIRC5, BCL2
34oral cancer10.0BIRC5
35bladder carcinoma10.0BCL2, BIRC5
36stomach cancer10.0BCL2, BIRC5
37lung cancer10.0BIRC5, BCL2
38prostate cancer10.0BCL2, BIRC5
39colorectal cancer10.0BIRC5, BCL2
40ovarian cancer10.0BIRC5, BCL2
41colon cancer10.0BIRC5, BCL2

Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to cervical carcinosarcoma

Clinical Features for Cervical Carcinosarcoma

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Drugs & Therapeutics for Cervical Carcinosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cervical Carcinosarcoma

Drug clinical trials:

Search ClinicalTrials for Cervical Carcinosarcoma

Search NIH Clinical Center for Cervical Carcinosarcoma

Search CenterWatch for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

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Anatomical Context for Cervical Carcinosarcoma

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32MalaCards
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MalaCards organs/tissues related to Cervical Carcinosarcoma:

32
Uterus

Animal Models for Cervical Carcinosarcoma or affiliated genes

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Publications for Cervical Carcinosarcoma

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Sources:
50PubMed
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Articles related to Cervical Carcinosarcoma:

idTitleAuthorsYear
1
Eight cases of malignant mixed mA1llerian tumor (carcinosarcoma) of the uterus: Findings in surepatha8c cervical cytology. (22865798)
2014
2
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. (23651629)
2013
3
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. (20668868)
2011
4
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. (21446343)
2011
5
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. (19263060)
2009
6
Cervical carcinosarcoma: a case report. (18357808)
2008
7
Case of uterine cervical carcinosarcoma. (16176508)
2005
8
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. (9441782)
1997
9
Cervical carcinosarcoma: a case report. (3957124)
1986

Genetic Variations for Cervical Carcinosarcoma

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Expression for genes affiliated with Cervical Carcinosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Carcinosarcoma

Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for genes affiliated with Cervical Carcinosarcoma

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Sources:
51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems
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Pathways related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development PDGF signaling via STATs and NF-kB
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9.1BCL2, BIRC5
29.1BCL2, BIRC5
3
Hide members
9.1BCL2, BIRC5
49.1BCL2, BIRC5
5
Hide members
9.1BIRC5, BCL2
6
Hide members
9.1BCL2, BIRC5
7
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
9.1BCL2, BIRC5
8
Apoptosis and survival Apoptotic TNF-family pathways
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9.1BIRC5, BCL2
99.1BCL2, BIRC5
109.1BCL2, BIRC5

Compounds for genes affiliated with Cervical Carcinosarcoma

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1ponicidin449.6BCL2, BIRC5
2naphtho(1,2-b)furan-4,5-dione449.6BIRC5, BCL2
3betulinic acid44 2810.6BIRC5, BCL2
4hoechst 33342449.6BIRC5, BCL2
5bryostatin 1449.6BIRC5, BCL2
6taxane449.6BCL2, BIRC5
7noxa449.6BCL2, BIRC5
82-chlorodeoxyadenosine449.6BCL2, BIRC5
9indole-3-carbinol449.6BIRC5, BCL2
10sulindac44 1110.6BCL2, BIRC5
11dutp449.6BCL2, BIRC5
12topotecan44 1110.6BIRC5, BCL2
13suberoylanilide hydroxamic acid449.6BCL2, BIRC5
14mitoxantrone44 49 1111.5BCL2, BIRC5
15fludarabine44 1110.5BCL2, BIRC5
16roscovitine449.5BIRC5, BCL2
17flavopiridol44 1110.5BCL2, BIRC5
18rituximab44 49 1111.5BCL2, BIRC5
19daunorubicin44 49 1111.5BCL2, BIRC5
20celecoxib44 59 28 49 11 2414.5BCL2, BIRC5
21bortezomib44 1110.5BIRC5, BCL2
22adpribose449.5BIRC5, BCL2
23gemcitabine44 49 1111.5BIRC5, BCL2
24mitomycin c449.5BCL2, BIRC5
25lactacystin449.5BCL2, BIRC5
26thymidylate449.5BIRC5, BCL2
27resveratrol44 59 11 2412.5BCL2, BIRC5
28adriamycin449.5BIRC5, BCL2
29docetaxel44 49 59 1112.5BCL2, BIRC5
30troglitazone44 28 59 1112.5BIRC5, BCL2
31camptothecin44 59 1111.5BIRC5, BCL2
32egcg449.5BIRC5, BCL2
33mg 13244 5910.5BIRC5, BCL2
34quercetin44 59 11 2412.4BCL2, BIRC5
35imatinib44 49 1111.4BCL2, BIRC5
36curcumin449.4BCL2, BIRC5
37arsenite44 2410.4BCL2, BIRC5
385fluorouracil449.4BCL2, BIRC5
39etoposide44 49 59 1112.4BIRC5, BCL2
40n acetylcysteine449.4BCL2, BIRC5
41sb 20358044 5910.4BIRC5, BCL2
42butyrate449.3BIRC5, BCL2
43tamoxifen44 49 28 1112.3BCL2, BIRC5
44paclitaxel44 49 1111.3BIRC5, BCL2
45rapamycin449.2BCL2, BIRC5
46pd 98,059449.2BCL2, BIRC5
47ly294002449.1BCL2, BIRC5
48actinomycin d449.1BIRC5, BCL2
49wortmannin449.0BIRC5, BCL2
50doxorubicin44 49 1110.8BCL2, BIRC5

GO Terms for genes affiliated with Cervical Carcinosarcoma

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16Gene Ontology
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Molecular functions related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:0469829.1BCL2, BIRC5

Products for genes affiliated with Cervical Carcinosarcoma

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  • Antibodies
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Sources for Cervical Carcinosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet