MCID: CRV036
MIFTS: 32

Cervical Carcinosarcoma malady

Cancer diseases category
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Summaries for Cervical Carcinosarcoma

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33MalaCards
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MalaCards: Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to cervicitis and cervical wilms' tumor. An important gene associated with Cervical Carcinosarcoma is BIRC5 (baculoviral IAP repeat containing 5), and among its related pathways are Apoptosis and Autophagy and TNF Signaling. The compounds ponicidin and naphtho(1,2-b)furan-4,5-dione have been mentioned in the context of this disorder.

Aliases & Classifications for Cervical Carcinosarcoma

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Sources:
8Disease Ontology, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical carcinosarcoma 8 62
cervical malignant mixed mesodermal mullerian tumor 8
cervical mixed epithelial and mesenchymal neoplasm 8
cervical malignant mixed mullerian tumor 8
malignant mixed mesodermal tumor 62


External Ids:

Disease Ontology8 DOID:4112
NCIt40 C36097

Related Diseases for Cervical Carcinosarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to cervical carcinosarcoma

Symptoms for Cervical Carcinosarcoma

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Drugs & Therapeutics for Cervical Carcinosarcoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Cervical Carcinosarcoma

Search NIH Clinical Center for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

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Anatomical Context for Cervical Carcinosarcoma

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Animal Models for Cervical Carcinosarcoma or affiliated genes

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Publications for Cervical Carcinosarcoma

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52PubMed
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Articles related to Cervical Carcinosarcoma:

idTitleAuthorsYear
1
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. (23651629)
2013
2
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. (20668868)
2011
3
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. (21446343)
2011
4
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. (19263060)
2009
5
Cervical carcinosarcoma: a case report. (18357808)
2008
6
Case of uterine cervical carcinosarcoma. (16176508)
2005
7
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. (9441782)
1997
8
Cervical carcinosarcoma: a case report. (3957124)
1986

Variations for Cervical Carcinosarcoma

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Expression for genes affiliated with Cervical Carcinosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Carcinosarcoma

Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for genes affiliated with Cervical Carcinosarcoma

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Sources:
50PathCards, 5Cell Signaling Technology, 57SinoBiological, 54R&D Systems, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 55Reactome
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Pathways related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1BIRC5, BCL2
2
Show member pathways
9.1BIRC5, BCL2
3
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1BCL2, BIRC5
49.1BIRC5, BCL2
5
Show member pathways
9.1BIRC5, BCL2
6
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1BCL2, BIRC5
7
Show member pathways
Signal transduction PTEN pathway60
9.1BIRC5, BCL2
8
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.1BIRC5, BCL2
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.1BIRC5, BCL2
109.1BCL2, BIRC5
11
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.1BIRC5, BCL2
129.1BIRC5, BCL2

Compounds for genes affiliated with Cervical Carcinosarcoma

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1ponicidin459.6BIRC5, BCL2
2naphtho(1,2-b)furan-4,5-dione459.6BIRC5, BCL2
3betulinic acid45 2910.6BIRC5, BCL2
4hoechst 33342459.6BCL2, BIRC5
5bryostatin 1459.6BIRC5, BCL2
6taxane459.6BIRC5, BCL2
7noxa459.6BCL2, BIRC5
82-chlorodeoxyadenosine459.6BIRC5, BCL2
9indole-3-carbinol459.6BIRC5, BCL2
10dutp459.6BCL2, BIRC5
11sulindac45 1110.6BCL2, BIRC5
12topotecan45 1110.6BIRC5, BCL2
13suberoylanilide hydroxamic acid459.6BCL2, BIRC5
14mitoxantrone45 51 1111.5BIRC5, BCL2
15roscovitine459.5BIRC5, BCL2
16fludarabine45 51 1111.5BIRC5, BCL2
17flavopiridol45 1110.5BCL2, BIRC5
18rituximab45 51 1111.5BIRC5, BCL2
19daunorubicin45 51 1111.5BIRC5, BCL2
20vinblastine45 51 1111.5BCL2, BIRC5
21celecoxib45 61 29 51 24 1114.5BIRC5, BCL2
22bortezomib45 51 1111.5BIRC5, BCL2
23pdtc459.5BCL2, BIRC5
24adpribose459.5BIRC5, BCL2
25gemcitabine45 51 1111.5BIRC5, BCL2
26mitomycin c459.5BCL2, BIRC5
27lactacystin459.5BIRC5, BCL2
28thymidylate459.5BIRC5, BCL2
29vincristine45 51 1111.5BCL2, BIRC5
30resveratrol45 61 24 1112.5BIRC5, BCL2
31adriamycin459.5BIRC5, BCL2
32troglitazone45 29 61 1112.5BCL2, BIRC5
33camptothecin45 61 1111.5BIRC5, BCL2
34docetaxel45 51 61 1112.4BIRC5, BCL2
35egcg459.4BCL2, BIRC5
36mg 13245 6110.4BIRC5, BCL2
37quercetin45 61 24 1112.4BIRC5, BCL2
38imatinib45 51 1111.4BCL2, BIRC5
39curcumin459.4BIRC5, BCL2
40arsenite45 2410.4BIRC5, BCL2
415fluorouracil459.4BCL2, BIRC5
42etoposide45 51 61 1112.3BIRC5, BCL2
43n acetylcysteine459.3BIRC5, BCL2
44sb 20358045 6110.3BCL2, BIRC5
45butyrate459.2BIRC5, BCL2
46tamoxifen45 51 29 1112.2BIRC5, BCL2
47paclitaxel45 51 1111.1BCL2, BIRC5
48ly294002459.1BIRC5, BCL2
49rapamycin459.0BIRC5, BCL2
50pd 98,059458.8BIRC5, BCL2

GO Terms for genes affiliated with Cervical Carcinosarcoma

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Sources:
16Gene Ontology
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Biological processes related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:0069159.1BIRC5, BCL2
2negative regulation of apoptotic processGO:0430668.8BIRC5, BCL2

Molecular functions related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428039.1BIRC5, BCL2
2protein heterodimerization activityGO:0469829.0BIRC5, BCL2
3identical protein bindingGO:0428028.8BIRC5, BCL2

Products for genes affiliated with Cervical Carcinosarcoma

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  • Antibodies
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Sources for Cervical Carcinosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet