MCID: CRV036
MIFTS: 32

Cervical Carcinosarcoma malady

Cancer diseases category

Summaries for Cervical Carcinosarcoma

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34MalaCards
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MalaCards: Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to cervicitis and cervical wilms' tumor. An important gene associated with Cervical Carcinosarcoma is BIRC5 (baculoviral IAP repeat containing 5), and among its related pathways are Apoptosis and Autophagy and TNF Signaling. The compounds ponicidin and naphtho(1,2-b)furan-4,5-dione have been mentioned in the context of this disorder.

Aliases & Classifications for Cervical Carcinosarcoma

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Sources:
9Disease Ontology, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical carcinosarcoma 9 63
cervical malignant mixed mesodermal mullerian tumor 9
cervical mixed epithelial and mesenchymal neoplasm 9
cervical malignant mixed mullerian tumor 9
malignant mixed mesodermal tumor 63


External Ids:

Disease Ontology9 DOID:4112
NCIt41 C36097

Related Diseases for Cervical Carcinosarcoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to cervical carcinosarcoma

Symptoms for Cervical Carcinosarcoma

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Drugs & Therapeutics for Cervical Carcinosarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Cervical Carcinosarcoma

Drug clinical trials:

Search ClinicalTrials for Cervical Carcinosarcoma

Search NIH Clinical Center for Cervical Carcinosarcoma

Search CenterWatch for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

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Anatomical Context for Cervical Carcinosarcoma

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Animal Models for Cervical Carcinosarcoma or affiliated genes

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Publications for Cervical Carcinosarcoma

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53PubMed
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Articles related to Cervical Carcinosarcoma:

idTitleAuthorsYear
1
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. (23651629)
2013
2
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. (20668868)
2011
3
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. (21446343)
2011
4
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. (19263060)
2009
5
Cervical carcinosarcoma: a case report. (18357808)
2008
6
Case of uterine cervical carcinosarcoma. (16176508)
2005
7
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. (9441782)
1997
8
Cervical carcinosarcoma: a case report. (3957124)
1986

Variations for Cervical Carcinosarcoma

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Expression for genes affiliated with Cervical Carcinosarcoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Carcinosarcoma

Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for genes affiliated with Cervical Carcinosarcoma

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Sources:
51PathCards, 5Cell Signaling Technology, 58SinoBiological, 55R&D Systems, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 56Reactome
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Pathways related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1BIRC5, BCL2
2
Show member pathways
9.1BIRC5, BCL2
3
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1BCL2, BIRC5
49.1BIRC5, BCL2
5
Show member pathways
9.1BIRC5, BCL2
6
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.1BCL2, BIRC5
7
Show member pathways
Signal transduction PTEN pathway61
9.1BIRC5, BCL2
8
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway61
9.1BIRC5, BCL2
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
9.1BIRC5, BCL2
109.1BCL2, BIRC5
11
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.1BIRC5, BCL2
129.1BIRC5, BCL2

Compounds for genes affiliated with Cervical Carcinosarcoma

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1ponicidin469.6BIRC5, BCL2
2naphtho(1,2-b)furan-4,5-dione469.6BIRC5, BCL2
3betulinic acid46 3010.6BIRC5, BCL2
4hoechst 33342469.6BCL2, BIRC5
5bryostatin 1469.6BIRC5, BCL2
6taxane469.6BIRC5, BCL2
7noxa469.6BCL2, BIRC5
82-chlorodeoxyadenosine469.6BIRC5, BCL2
9indole-3-carbinol469.6BIRC5, BCL2
10dutp469.6BCL2, BIRC5
11sulindac46 1210.6BCL2, BIRC5
12topotecan46 1210.6BIRC5, BCL2
13suberoylanilide hydroxamic acid469.6BCL2, BIRC5
14mitoxantrone46 52 1211.5BIRC5, BCL2
15roscovitine469.5BIRC5, BCL2
16fludarabine46 52 1211.5BIRC5, BCL2
17flavopiridol46 1210.5BCL2, BIRC5
18rituximab46 52 1211.5BIRC5, BCL2
19daunorubicin46 52 1211.5BIRC5, BCL2
20vinblastine46 52 1211.5BCL2, BIRC5
21celecoxib46 62 30 52 25 1214.5BIRC5, BCL2
22bortezomib46 52 1211.5BIRC5, BCL2
23pdtc469.5BCL2, BIRC5
24adpribose469.5BIRC5, BCL2
25gemcitabine46 52 1211.5BIRC5, BCL2
26mitomycin c469.5BCL2, BIRC5
27lactacystin469.5BIRC5, BCL2
28thymidylate469.5BIRC5, BCL2
29vincristine46 52 1211.5BCL2, BIRC5
30resveratrol46 62 25 1212.5BIRC5, BCL2
31adriamycin469.5BIRC5, BCL2
32troglitazone46 30 62 1212.5BCL2, BIRC5
33camptothecin46 62 1211.5BIRC5, BCL2
34docetaxel46 52 62 1212.4BIRC5, BCL2
35egcg469.4BCL2, BIRC5
36mg 13246 6210.4BIRC5, BCL2
37quercetin46 62 25 1212.4BIRC5, BCL2
38imatinib46 52 1211.4BCL2, BIRC5
39curcumin469.4BIRC5, BCL2
40arsenite46 2510.4BIRC5, BCL2
415fluorouracil469.4BCL2, BIRC5
42etoposide46 52 62 1212.3BIRC5, BCL2
43n acetylcysteine469.3BIRC5, BCL2
44sb 20358046 6210.3BCL2, BIRC5
45butyrate469.2BIRC5, BCL2
46tamoxifen46 52 30 1212.2BIRC5, BCL2
47paclitaxel46 52 1211.1BCL2, BIRC5
48ly294002469.1BIRC5, BCL2
49rapamycin469.0BIRC5, BCL2
50pd 98,059468.8BIRC5, BCL2

GO Terms for genes affiliated with Cervical Carcinosarcoma

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17Gene Ontology
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Biological processes related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:0069159.1BIRC5, BCL2
2negative regulation of apoptotic processGO:0430668.8BIRC5, BCL2

Molecular functions related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428039.1BIRC5, BCL2
2protein heterodimerization activityGO:0469829.0BIRC5, BCL2
3identical protein bindingGO:0428028.8BIRC5, BCL2

Products for genes affiliated with Cervical Carcinosarcoma

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  • Antibodies
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Sources for Cervical Carcinosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet