MCID: CRV036
MIFTS: 38

Cervical Carcinosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Carcinosarcoma

MalaCards integrated aliases for Cervical Carcinosarcoma:

Name: Cervical Carcinosarcoma 12 14 69
Cervical Malignant Mixed Mesodermal Mullerian Tumor 12
Cervical Mixed Epithelial and Mesenchymal Neoplasm 12
Cervical Malignant Mixed Mullerian Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4112

Summaries for Cervical Carcinosarcoma

MalaCards based summary : Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to cervical adenosarcoma and cervical wilms' tumor. An important gene associated with Cervical Carcinosarcoma is BIRC5 (Baculoviral IAP Repeat Containing 5), and among its related pathways/superpathways are Endometrial cancer and Integrated Breast Cancer Pathway. The drugs Carboplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and cervix, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Cervical Carcinosarcoma

Diseases related to Cervical Carcinosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
id Related Disease Score Top Affiliating Genes
1 cervical adenosarcoma 11.0
2 cervical wilms' tumor 11.0
3 carcinosarcoma of the cervix uteri 11.0
4 blake pouch cyst 10.7 BCL2 MME
5 berk-tabatznik syndrome 10.6 BCL2 PGR
6 ureter urothelial papilloma 10.6 BIRC5 TP53
7 central nervous system tuberculosis 10.6 MME PGR
8 panophthalmitis 10.5 MME PGR
9 pseudounicornuate uterus 10.5 MME PGR
10 fallopian tube squamous cell carcinoma 10.5 MAPK8IP1 TP53
11 papilloma 10.5 MME PGR
12 liver angiosarcoma 10.5 MME PGR
13 blastema predominant kidney wilms' tumor 10.5 PGR TP53
14 pediatric meningioma 10.5 BIRC5 PGR
15 sebaceous adenoma 10.5 MME PGR
16 breast myoepithelial neoplasm 10.5 PGR TP53
17 breast angiomatosis 10.5 ESR1 MME
18 leiomyoma cutis 10.5 PGR TP53
19 prostatic acinar adenocarcinoma 10.5 PGR TP53
20 pylorus cancer 10.5 BCL2 TP53
21 embryonal extrahepatic bile duct rhabdomyosarcoma 10.5 MME TP53
22 intraductal breast myoepitheliosis 10.5 PGR TP53
23 spiradenoma 10.5 MME PGR
24 chronic salpingitis 10.5 ESR1 MME
25 bartholin's gland benign neoplasm 10.4 ESR1 PGR
26 trachea sarcoma 10.4 MME PGR
27 gallbladder leiomyoma 10.4 ESR1 PGR
28 breast pericanalicular fibroadenoma 10.4 PGR TP53
29 glaucoma, hereditary 10.4 ESR1 PGR
30 colon neuroendocrine neoplasm 10.4 PGR TP53
31 fallopian tube benign neoplasm 10.4 ESR1 PGR
32 hepatic osteogenic sarcoma 10.4 MME TP53
33 paranasal sinus disease 10.4 ESR1 PGR
34 sparse hair ptosis mental retardation 10.4 BCL2 TP53
35 dartoic leiomyoma 10.4 ESR1 PGR
36 urinary bladder inverted papilloma 10.4 ESR1 PGR
37 spinal cancer 10.4 ESR1 PGR
38 subglottis verrucous carcinoma 10.4 ESR1 PGR
39 central nervous system germ cell tumor 10.4 PGR TP53
40 deafness, autosomal dominant 8/12 10.4 ESR1 PGR
41 breast fibrosarcoma 10.4 PGR TP53
42 gastric tubular adenocarcinoma 10.4 ESR1 PGR
43 her2-receptor positive breast cancer 10.4 ESR1 PGR
44 superficial basal cell carcinoma 10.4 ESR1 PGR
45 fallopian tube clear cell adenocarcinoma 10.4 ESR1 TP53
46 sarcomatoid squamous cell skin carcinoma 10.4 ESR1 PGR
47 otitis externa 10.4 PGR TP53
48 pineal region meningioma 10.4 ESR1 PGR
49 bladder colloid adenocarcinoma 10.4 ESR1 PGR
50 endophthalmitis 10.4 ESR1 PGR

Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to Cervical Carcinosarcoma

Symptoms & Phenotypes for Cervical Carcinosarcoma

MGI Mouse Phenotypes related to Cervical Carcinosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 PGR TP53 BCL2 BIRC5 ESR1 GP5
2 endocrine/exocrine gland MP:0005379 9.91 BCL2 BIRC5 ESR1 MAPK8IP1 MAPK8IP2 PGR
3 immune system MP:0005387 9.8 BCL2 BIRC5 ESR1 GP6 MME PGR
4 integument MP:0010771 9.63 BCL2 ESR1 GP6 MME PGR TP53
5 mortality/aging MP:0010768 9.56 TP53 BCL2 BIRC5 ESR1 GP6 MAPK8IP1
6 reproductive system MP:0005389 9.17 BCL2 ESR1 GP6 MAPK8IP1 MAPK8IP2 PGR

Drugs & Therapeutics for Cervical Carcinosarcoma

Drugs for Cervical Carcinosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
2
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
3
Doxil Approved June 1999 Phase 1, Phase 2 31703
4 Anti-Bacterial Agents Phase 1, Phase 2
5 Antibiotics, Antitubercular Phase 1, Phase 2
6 Topoisomerase Inhibitors Phase 1, Phase 2
7 Fluorodeoxyglucose F18 Phase 1, Phase 2
8 Radiopharmaceuticals Phase 1, Phase 2
9
Bevacizumab Approved, Investigational Phase 1 216974-75-3
10
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
11 Antibodies Phase 1
12 Antibodies, Monoclonal Phase 1
13 Immunoglobulins Phase 1
14 Immunotoxins Phase 1
15 Albumin-Bound Paclitaxel Phase 1
16 Angiogenesis Inhibitors Phase 1
17 Angiogenesis Modulating Agents Phase 1
18 Antimitotic Agents Phase 1
19 Antineoplastic Agents, Phytogenic Phase 1
20 Endothelial Growth Factors Phase 1
21 Mitogens Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Liposomal Doxorubicin and Carboplatin in Treating Patients With Gynecologic Cancer Completed NCT00032162 Phase 1, Phase 2 carboplatin;pegylated liposomal doxorubicin hydrochloride
2 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
3 Fludeoxyglucose F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer Active, not recruiting NCT00416455 Phase 1, Phase 2 ferumoxtran-10
4 Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors Completed NCT00066651 Phase 1
5 Immunotoxin Therapy in Treating Patients With Advanced Cancer Completed NCT00006981 Phase 1
6 Suitability of DCE-MRI for Detection of Vascular Changes After VBT Recruiting NCT01991808 Phase 1
7 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Suspended NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Search NIH Clinical Center for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

Anatomical Context for Cervical Carcinosarcoma

MalaCards organs/tissues related to Cervical Carcinosarcoma:

39
Lymph Node, Endothelial, Cervix

Publications for Cervical Carcinosarcoma

Articles related to Cervical Carcinosarcoma:

id Title Authors Year
1
Therapy Modalities, Prognostic Factors, and Outcome of the Primary Cervical Carcinosarcoma: Meta-analysis of Extremely Rare Tumor of Cervix. ( 28708788 )
2017
2
Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study. ( 25400816 )
2014
3
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. ( 23651629 )
2013
4
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. ( 21446343 )
2011
5
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. ( 20668868 )
2011
6
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. ( 19263060 )
2009
7
Cervical carcinosarcoma: a case report. ( 18357808 )
2008
8
Case of uterine cervical carcinosarcoma. ( 16176508 )
2005
9
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. ( 9441782 )
1997
10
Cervical carcinosarcoma: a case report. ( 3957124 )
1986

Variations for Cervical Carcinosarcoma

Expression for Cervical Carcinosarcoma

Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for Cervical Carcinosarcoma

GO Terms for Cervical Carcinosarcoma

Cellular components related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 8.92 BCL2 ESR1 MAPK8IP2 TP53

Biological processes related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.67 BCL2 BIRC5 MAPK8IP1 TP53
2 cellular response to glucose starvation GO:0042149 9.51 BCL2 TP53
3 response to gamma radiation GO:0010332 9.49 BCL2 TP53
4 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.48 BCL2 TP53
5 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.46 BCL2 TP53
6 behavioral fear response GO:0001662 9.43 BCL2 MAPK8IP2
7 cell aging GO:0007569 9.4 BCL2 TP53
8 negative regulation of intrinsic apoptotic signaling pathway GO:2001243 9.32 BCL2 MAPK8IP1
9 regulation of JNK cascade GO:0046328 9.26 MAPK8IP1 MAPK8IP2
10 replicative senescence GO:0090399 9.16 MME TP53
11 regulation of mitochondrial membrane permeability GO:0046902 8.96 BCL2 TP53
12 regulation of apoptotic process GO:0042981 8.92 BCL2 BIRC5 ESR1 TP53

Molecular functions related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.46 ESR1 MAPK8IP1 MAPK8IP2 TP53
2 steroid binding GO:0005496 9.32 ESR1 PGR
3 protein phosphatase 2A binding GO:0051721 9.26 BCL2 TP53
4 enzyme binding GO:0019899 9.26 BIRC5 ESR1 PGR TP53
5 MAP-kinase scaffold activity GO:0005078 8.62 MAPK8IP1 MAPK8IP2
6 protein binding GO:0005515 10.07 BCL2 BIRC5 ESR1 GP5 GP6 MAPK8IP1

Sources for Cervical Carcinosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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