MCID: CRV036
MIFTS: 33

Cervical Carcinosarcoma malady

Cancer diseases category
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Summaries for Cervical Carcinosarcoma

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MalaCards based summary: Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to cervicitis and cervical wilms' tumor. An important gene associated with Cervical Carcinosarcoma is BIRC5 (baculoviral IAP repeat containing 5), and among its related pathways are Apoptosis and Autophagy and TNF Signaling. The compounds ponicidin and naphtho(1,2-b)furan-4,5-dione have been mentioned in the context of this disorder.

Aliases & Classifications for Cervical Carcinosarcoma

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Cervical Carcinosarcoma, Aliases & Descriptions:

Name: Cervical Carcinosarcoma 8 62
Cervical Malignant Mixed Mesodermal Mullerian Tumor 8
Cervical Mixed Epithelial and Mesenchymal Neoplasm 8
 
Cervical Malignant Mixed Mullerian Tumor 8
Malignant Mixed Mesodermal Tumor 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:4112
NCIt39 C36097

Related Diseases for Cervical Carcinosarcoma

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Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to cervical carcinosarcoma

Symptoms for Cervical Carcinosarcoma

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Drugs & Therapeutics for Cervical Carcinosarcoma

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Drug clinical trials:

Search ClinicalTrials for Cervical Carcinosarcoma

Search NIH Clinical Center for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

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Anatomical Context for Cervical Carcinosarcoma

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Animal Models for Cervical Carcinosarcoma or affiliated genes

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Publications for Cervical Carcinosarcoma

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Articles related to Cervical Carcinosarcoma:

idTitleAuthorsYear
1
Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study. (25400816)
2014
2
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. (23651629)
2013
3
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. (20668868)
2011
4
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. (21446343)
2011
5
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. (19263060)
2009
6
Cervical carcinosarcoma: a case report. (18357808)
2008
7
Case of uterine cervical carcinosarcoma. (16176508)
2005
8
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. (9441782)
1997
9
Cervical carcinosarcoma: a case report. (3957124)
1986

Variations for Cervical Carcinosarcoma

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Expression for genes affiliated with Cervical Carcinosarcoma

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Expression patterns in normal tissues for genes affiliated with Cervical Carcinosarcoma

Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for genes affiliated with Cervical Carcinosarcoma

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Pathways related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1BIRC5, BCL2
2
Show member pathways
9.1BIRC5, BCL2
3
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1BCL2, BIRC5
49.1BIRC5, BCL2
5
Show member pathways
9.1BCL2, BIRC5
6
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1BCL2, BIRC5
7
Show member pathways
Signal transduction PTEN pathway60
9.1BIRC5, BCL2
8
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.1BIRC5, BCL2
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.1BIRC5, BCL2
109.1BCL2, BIRC5
11
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.1BIRC5, BCL2
129.1BCL2, BIRC5

Compounds for genes affiliated with Cervical Carcinosarcoma

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Compounds related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1ponicidin449.6BCL2, BIRC5
2naphtho(1,2-b)furan-4,5-dione449.6BCL2, BIRC5
3betulinic acid44 2810.6BIRC5, BCL2
4hoechst 33342449.6BIRC5, BCL2
5bryostatin 1449.6BCL2, BIRC5
6taxane449.6BIRC5, BCL2
7noxa449.6BCL2, BIRC5
82-chlorodeoxyadenosine449.6BCL2, BIRC5
9indole-3-carbinol449.6BIRC5, BCL2
10sulindac44 1110.6BCL2, BIRC5
11dutp449.6BCL2, BIRC5
12topotecan44 1110.6BIRC5, BCL2
13suberoylanilide hydroxamic acid449.6BCL2, BIRC5
14mitoxantrone44 50 1111.5BIRC5, BCL2
15roscovitine449.5BCL2, BIRC5
16fludarabine44 50 1111.5BCL2, BIRC5
17flavopiridol44 1110.5BCL2, BIRC5
18rituximab44 50 1111.5BCL2, BIRC5
19daunorubicin44 50 1111.5BCL2, BIRC5
20vinblastine44 50 1111.5BIRC5, BCL2
21celecoxib44 61 28 50 24 1114.5BIRC5, BCL2
22bortezomib44 50 1111.5BIRC5, BCL2
23pdtc449.5BCL2, BIRC5
24adpribose449.5BIRC5, BCL2
25gemcitabine44 50 1111.5BIRC5, BCL2
26mitomycin c449.5BIRC5, BCL2
27lactacystin449.5BIRC5, BCL2
28thymidylate449.5BCL2, BIRC5
29vincristine44 50 1111.5BCL2, BIRC5
30resveratrol44 61 24 1112.5BIRC5, BCL2
31adriamycin449.5BCL2, BIRC5
32troglitazone44 28 61 1112.5BIRC5, BCL2
33camptothecin44 61 1111.5BIRC5, BCL2
34docetaxel44 50 61 1112.4BIRC5, BCL2
35egcg449.4BCL2, BIRC5
36mg 13244 6110.4BIRC5, BCL2
37quercetin44 61 24 1112.4BIRC5, BCL2
38imatinib44 50 1111.4BCL2, BIRC5
39curcumin449.4BIRC5, BCL2
40arsenite44 2410.4BIRC5, BCL2
415fluorouracil449.4BIRC5, BCL2
42etoposide44 50 61 1112.3BCL2, BIRC5
43n acetylcysteine449.3BIRC5, BCL2
44sb 20358044 6110.3BCL2, BIRC5
45butyrate449.2BCL2, BIRC5
46tamoxifen44 50 28 1112.2BIRC5, BCL2
47paclitaxel44 50 1111.1BIRC5, BCL2
48ly294002449.1BIRC5, BCL2
49rapamycin449.0BIRC5, BCL2
50pd 98,059448.8BCL2, BIRC5

GO Terms for genes affiliated with Cervical Carcinosarcoma

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Biological processes related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:0069159.1BIRC5, BCL2
2negative regulation of apoptotic processGO:0430668.8BIRC5, BCL2

Molecular functions related to Cervical Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428039.1BIRC5, BCL2
2protein heterodimerization activityGO:0469829.0BIRC5, BCL2
3identical protein bindingGO:0428028.8BIRC5, BCL2

Products for genes affiliated with Cervical Carcinosarcoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Cervical Carcinosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet