MCID: CRV036
MIFTS: 39

Cervical Carcinosarcoma

Categories: Cancer diseases

Aliases & Classifications for Cervical Carcinosarcoma

MalaCards integrated aliases for Cervical Carcinosarcoma:

Name: Cervical Carcinosarcoma 12 14 69
Cervical Malignant Mixed Mesodermal Mullerian Tumor 12
Cervical Mixed Epithelial and Mesenchymal Neoplasm 12
Cervical Malignant Mixed Mullerian Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4112

Summaries for Cervical Carcinosarcoma

MalaCards based summary : Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to cervical adenosarcoma and endometrial cancer. An important gene associated with Cervical Carcinosarcoma is BCL2 (BCL2, Apoptosis Regulator), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Bevacizumab and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include endothelial and cervix, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Cervical Carcinosarcoma

Diseases related to Cervical Carcinosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 cervical adenosarcoma 31.3 GP5 GP6 PGR
2 endometrial cancer 28.5 BCL2 ESR1 MME PGR TP53
3 carcinosarcoma of the cervix uteri 11.6
4 cervical wilms' tumor 11.1
5 intravascular large b-cell lymphoma 10.4 BCL2 MME
6 benign metastasizing leiomyoma 10.4 BCL2 PGR
7 squamous cell carcinoma of the larynx 10.3 BCL2 TP53
8 vulvar intraepithelial neoplasia 10.3 BIRC5 TP53
9 bladder transitional cell papilloma 10.3 BIRC5 TP53
10 testicular torsion 10.3 BCL2 TP53
11 benign breast phyllodes tumor 10.3 MME PGR
12 benign meningioma 10.3 BIRC5 PGR
13 focal cortical dysplasia, type ii 10.3 BCL2 TP53
14 sarcomatoid squamous cell skin carcinoma 10.3 MAPK8IP1 TP53
15 cystic nephroma 10.3 MME PGR
16 suppressor of tumorigenicity 3 10.3 BCL2 TP53
17 gastric lymphoma 10.3 BCL2 TP53
18 anogenital venereal wart 10.3 GP6 TP53
19 perivascular epithelioid cell tumor 10.3 MME PGR
20 endometrium carcinoma in situ 10.2 PGR TP53
21 soft tissue sarcoma 10.2 BCL2 TP53
22 papillary hidradenoma 10.2 MME PGR
23 endometrial stromal nodule 10.2 MME PGR
24 cervicitis 10.2
25 female reproductive endometrioid cancer 10.2 PGR TP53
26 breast malignant phyllodes tumor 10.2 PGR TP53
27 spermatocele 10.2 MME PGR
28 olfactory groove meningioma 10.2 PGR TP53
29 ovarian serous cystadenocarcinoma 10.2 BCL2 PGR
30 oropharynx cancer 10.2 GP6 TP53
31 dysgerminoma of ovary 10.2 MAPK8IP1 PGR
32 cll/sll 10.2 MME TP53
33 breast myofibroblastoma 10.2 ESR1 MME
34 chordoid glioma 10.2 PGR TP53
35 endocervical carcinoma 10.2 ESR1 MAPK8IP1
36 papillary serous adenocarcinoma 10.2 PGR TP53
37 uterine body mixed cancer 10.2 PGR TP53
38 intravenous leiomyomatosis 10.2 ESR1 MME
39 anterior cranial fossa meningioma 10.2 PGR TP53
40 microglandular adenosis 10.2 PGR TP53
41 vulvar syringoma 10.2 ESR1 PGR
42 lung leiomyoma 10.2 ESR1 PGR
43 glassy cell carcinoma of the cervix 10.2 ESR1 PGR
44 vulvar benign neoplasm 10.2 ESR1 PGR
45 trigonitis 10.2 ESR1 PGR
46 vulvar leiomyoma 10.2 ESR1 PGR
47 predominantly cortical thymoma 10.2 ESR1 PGR
48 breast medullary carcinoma 10.2 ESR1 PGR
49 breast scirrhous carcinoma 10.2 ESR1 PGR
50 progesterone resistance 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to Cervical Carcinosarcoma

Symptoms & Phenotypes for Cervical Carcinosarcoma

MGI Mouse Phenotypes related to Cervical Carcinosarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 BCL2 BIRC5 ESR1 GP5 GP6 MAPK8IP1
2 endocrine/exocrine gland MP:0005379 9.91 BCL2 BIRC5 ESR1 MAPK8IP1 MAPK8IP2 PGR
3 immune system MP:0005387 9.8 BCL2 BIRC5 ESR1 GP6 MME PGR
4 integument MP:0010771 9.63 GP6 MME PGR TP53 BCL2 ESR1
5 mortality/aging MP:0010768 9.56 BCL2 BIRC5 ESR1 GP6 MAPK8IP1 MAPK8IP2
6 reproductive system MP:0005389 9.17 BCL2 ESR1 GP6 MAPK8IP1 MAPK8IP2 PGR

Drugs & Therapeutics for Cervical Carcinosarcoma

Drugs for Cervical Carcinosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 1 216974-75-3
2
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
3 Albumin-Bound Paclitaxel Phase 1
4 Angiogenesis Inhibitors Phase 1
5 Angiogenesis Modulating Agents Phase 1
6 Antibodies Phase 1
7 Antibodies, Monoclonal Phase 1
8 Antimitotic Agents Phase 1
9 Antineoplastic Agents, Phytogenic Phase 1
10 Endothelial Growth Factors Phase 1
11 Immunoglobulins Phase 1
12 Mitogens Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Suspended NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Search NIH Clinical Center for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

Anatomical Context for Cervical Carcinosarcoma

MalaCards organs/tissues related to Cervical Carcinosarcoma:

38
Endothelial, Cervix

Publications for Cervical Carcinosarcoma

Articles related to Cervical Carcinosarcoma:

# Title Authors Year
1
Therapy Modalities, Prognostic Factors, and Outcome of the Primary Cervical Carcinosarcoma: Meta-analysis of Extremely Rare Tumor of Cervix. ( 28708788 )
2017
2
Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study. ( 25400816 )
2014
3
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. ( 23651629 )
2013
4
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. ( 20668868 )
2011
5
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. ( 21446343 )
2011
6
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. ( 19263060 )
2009
7
Cervical carcinosarcoma: a case report. ( 18357808 )
2008
8
Case of uterine cervical carcinosarcoma. ( 16176508 )
2005
9
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. ( 9441782 )
1997
10
Cervical carcinosarcoma: a case report. ( 3957124 )
1986

Variations for Cervical Carcinosarcoma

Expression for Cervical Carcinosarcoma

Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for Cervical Carcinosarcoma

GO Terms for Cervical Carcinosarcoma

Cellular components related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 8.92 BCL2 ESR1 MAPK8IP2 TP53

Biological processes related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.71 BCL2 BIRC5 MAPK8IP1 TP53
2 cellular response to glucose starvation GO:0042149 9.52 BCL2 TP53
3 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.51 BCL2 TP53
4 response to gamma radiation GO:0010332 9.49 BCL2 TP53
5 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.48 BCL2 TP53
6 behavioral fear response GO:0001662 9.46 BCL2 MAPK8IP2
7 cell aging GO:0007569 9.43 BCL2 TP53
8 negative regulation of intrinsic apoptotic signaling pathway GO:2001243 9.37 BCL2 MAPK8IP1
9 regulation of JNK cascade GO:0046328 9.32 MAPK8IP1 MAPK8IP2
10 regulation of mitochondrial membrane permeability GO:0046902 9.26 BCL2 TP53
11 replicative senescence GO:0090399 9.16 MME TP53
12 response to UV-B GO:0010224 8.96 BCL2 TP53
13 regulation of apoptotic process GO:0042981 8.92 BCL2 BIRC5 ESR1 TP53

Molecular functions related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.71 BCL2 ESR1 PGR TP53
2 identical protein binding GO:0042802 9.65 BCL2 BIRC5 ESR1 PGR TP53
3 protein kinase binding GO:0019901 9.46 ESR1 MAPK8IP1 MAPK8IP2 TP53
4 protein phosphatase 2A binding GO:0051721 9.37 BCL2 TP53
5 steroid binding GO:0005496 9.32 ESR1 PGR
6 enzyme binding GO:0019899 9.26 BIRC5 ESR1 PGR TP53
7 MAP-kinase scaffold activity GO:0005078 8.62 MAPK8IP1 MAPK8IP2
8 protein binding GO:0005515 10.13 BCL2 BIRC5 ESR1 GP5 GP6 MAPK8IP1

Sources for Cervical Carcinosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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