MCID: CRV036
MIFTS: 37

Cervical Carcinosarcoma malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Carcinosarcoma

Aliases & Descriptions for Cervical Carcinosarcoma:

Name: Cervical Carcinosarcoma 12 14 69
Cervical Malignant Mixed Mesodermal Mullerian Tumor 12
Cervical Mixed Epithelial and Mesenchymal Neoplasm 12
Cervical Malignant Mixed Mullerian Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4112

Summaries for Cervical Carcinosarcoma

MalaCards based summary : Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to carcinosarcoma of the cervix uteri and cervical adenosarcoma. An important gene associated with Cervical Carcinosarcoma is BCL2 (BCL2, Apoptosis Regulator), and among its related pathways/superpathways are Endometrial cancer and Integrated Breast Cancer Pathway. The drugs Doxorubicin and Carboplatin have been mentioned in the context of this disorder. Related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Cervical Carcinosarcoma

Diseases related to Cervical Carcinosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 carcinosarcoma of the cervix uteri 11.1
2 cervical adenosarcoma 11.0
3 cervical wilms' tumor 11.0
4 coloboma of eyelid 10.3 BCL2 MME
5 biemond syndrome 10.2 BCL2 PGR
6 inverted follicular keratosis 10.2 BIRC5 TP53
7 central nervous system tuberculosis 10.2 MME PGR
8 kidney disease 10.2 BCL2 TP53
9 aortitis 10.2 PGR TP53
10 papilloma 10.2 MME PGR
11 choriocarcinoma of ovary 10.2 MAPK8IP1 TP53
12 liver angiosarcoma 10.2 MME PGR
13 uterine hypoplasia 10.2 MME PGR
14 pericardium leiomyoma 10.2 PGR TP53
15 breast ductal carcinoma 10.2 PGR TP53
16 panophthalmitis 10.2 MME PGR
17 pyloric antrum cancer 10.1 BCL2 TP53
18 breast angiomatosis 10.1 ESR1 MME
19 acinar cell carcinoma 10.1 PGR TP53
20 endocervicitis 10.1 BCL2 BIRC5 PGR
21 classic congenital mesoblastic nephroma 10.1 PGR TP53
22 non-suppurative otitis media 10.1 GP6 TP53
23 porokeratosis 10.1 PGR TP53
24 small intestinal vasoactive intestinal peptide producing tumor 10.1 ESR1 MME
25 bartholin's gland benign neoplasm 10.1 ESR1 PGR
26 cardiovascular organ benign neoplasm 10.1 ESR1 PGR
27 appendix leiomyoma 10.1 ESR1 PGR
28 bronchus adenoma 10.1 ESR1 PGR
29 glioma 10.1 ESR1 PGR
30 ovarian benign neoplasm 10.1 ESR1 PGR
31 plexiform neurofibroma 10.1 ESR1 PGR
32 breast pericanalicular fibroadenoma 10.1 PGR TP53
33 sebaceous adenoma 10.1 MME PGR
34 paranasal sinus disease 10.1 ESR1 PGR
35 deafness, autosomal recessive 21 10.1 ESR1 PGR
36 cervicitis 10.1
37 cervical lymphoepithelioma-like carcinoma 10.1 ESR1 PGR
38 common bile duct neoplasm 10.1 BIRC5 PGR
39 histiocytic and dendritic cell cancer 10.1 ESR1 PGR
40 atypical lipomatous tumor 10.1 ESR1 PGR
41 statin toxicity 10.1 BCL2 BIRC5 TP53
42 pediatric intraocular retinoblastoma 10.1 ESR1 PGR
43 congenital disorder of glycosylation, type ic 10.1 ESR1 PGR
44 her2-receptor negative breast cancer 10.1 ESR1 PGR
45 intestinal perforation 10.1 ESR1 PGR
46 perlman syndrome 10.1 ESR1 PGR
47 bladder clear cell adenocarcinoma 10.1 ESR1 TP53
48 nervous system hibernoma 10.1 ESR1 PGR
49 bladder adenocarcinoma 10.1 ESR1 PGR
50 anal neuroendocrine tumor 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to Cervical Carcinosarcoma

Symptoms & Phenotypes for Cervical Carcinosarcoma

MGI Mouse Phenotypes related to Cervical Carcinosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 MAPK8IP2 MME PGR TP53 BCL2 BIRC5
2 endocrine/exocrine gland MP:0005379 9.91 BCL2 BIRC5 ESR1 MAPK8IP1 MAPK8IP2 PGR
3 immune system MP:0005387 9.8 PGR TP53 BCL2 BIRC5 ESR1 GP6
4 integument MP:0010771 9.63 BCL2 ESR1 GP6 MME PGR TP53
5 mortality/aging MP:0010768 9.56 BCL2 BIRC5 ESR1 GP6 MAPK8IP1 MAPK8IP2
6 reproductive system MP:0005389 9.17 BCL2 ESR1 GP6 MAPK8IP1 MAPK8IP2 PGR

Drugs & Therapeutics for Cervical Carcinosarcoma

Drugs for Cervical Carcinosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
2
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
3
nivolumab Approved Phase 2 946414-94-4
4
Doxil Approved June 1999 Phase 1, Phase 2 31703
5 Topoisomerase Inhibitors Phase 1, Phase 2
6 Anti-Bacterial Agents Phase 1, Phase 2
7 Immunoglobulins Phase 2,Phase 1
8 Antibodies, Monoclonal Phase 2,Phase 1
9 Antibiotics, Antitubercular Phase 1, Phase 2
10 Antibodies Phase 2,Phase 1
11 Fluorodeoxyglucose F18 Phase 1, Phase 2
12 Radiopharmaceuticals Phase 1, Phase 2
13
Fluorouracil Approved Phase 1 51-21-8 3385
14
Belinostat Approved, Investigational Phase 1 866323-14-0
15
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
16
Bevacizumab Approved, Investigational Phase 1 216974-75-3
17 Histone Deacetylase Inhibitors Phase 1
18 Androgens Phase 1
19 Immunosuppressive Agents Phase 1
20 Immunotoxins Phase 1
21 Antimetabolites Phase 1
22 Antimetabolites, Antineoplastic Phase 1
23 Mitogens Phase 1
24 Albumin-Bound Paclitaxel Phase 1
25 Angiogenesis Inhibitors Phase 1
26 Angiogenesis Modulating Agents Phase 1
27 Endothelial Growth Factors Phase 1
28 Immunoglobulin G Phase 1
29 Antimitotic Agents Phase 1
30 Antineoplastic Agents, Phytogenic Phase 1
31 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Liposomal Doxorubicin and Carboplatin in Treating Patients With Gynecologic Cancer Completed NCT00032162 Phase 1, Phase 2
2 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2
3 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
4 Fludeoxyglucose F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer Active, not recruiting NCT00416455 Phase 1, Phase 2
5 Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors Completed NCT00066651 Phase 1
6 Immunotoxin Therapy in Treating Patients With Advanced Cancer Completed NCT00006981 Phase 1
7 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1
8 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Recruiting NCT02020707 Phase 1
9 Suitability of DCE-MRI for Detection of Vascular Changes After VBT Recruiting NCT01991808 Phase 1
10 Study of Previously Collected and Stored Tissue Samples From Patients Previously Enrolled in a Completed National Cancer Institute Clinical Trial Completed NCT00904514

Search NIH Clinical Center for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

Anatomical Context for Cervical Carcinosarcoma

Publications for Cervical Carcinosarcoma

Articles related to Cervical Carcinosarcoma:

id Title Authors Year
1
Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study. ( 25400816 )
2014
2
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. ( 23651629 )
2013
3
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. ( 20668868 )
2011
4
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. ( 21446343 )
2011
5
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. ( 19263060 )
2009
6
Cervical carcinosarcoma: a case report. ( 18357808 )
2008
7
Case of uterine cervical carcinosarcoma. ( 16176508 )
2005
8
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. ( 9441782 )
1997
9
Cervical carcinosarcoma: a case report. ( 3957124 )
1986

Variations for Cervical Carcinosarcoma

Expression for Cervical Carcinosarcoma

Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for Cervical Carcinosarcoma

GO Terms for Cervical Carcinosarcoma

Cellular components related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 8.92 BCL2 ESR1 MAPK8IP2 TP53

Biological processes related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.67 BCL2 BIRC5 MAPK8IP1 TP53
2 cellular response to glucose starvation GO:0042149 9.51 BCL2 TP53
3 response to gamma radiation GO:0010332 9.49 BCL2 TP53
4 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.48 BCL2 TP53
5 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.46 BCL2 TP53
6 cell aging GO:0007569 9.43 BCL2 TP53
7 behavioral fear response GO:0001662 9.4 BCL2 MAPK8IP2
8 regulation of JNK cascade GO:0046328 9.32 MAPK8IP1 MAPK8IP2
9 negative regulation of intrinsic apoptotic signaling pathway GO:2001243 9.26 BCL2 MAPK8IP1
10 replicative senescence GO:0090399 9.16 MME TP53
11 regulation of mitochondrial membrane permeability GO:0046902 8.96 BCL2 TP53
12 regulation of apoptotic process GO:0042981 8.92 BCL2 BIRC5 ESR1 TP53

Molecular functions related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.46 ESR1 MAPK8IP1 MAPK8IP2 TP53
2 steroid binding GO:0005496 9.32 ESR1 PGR
3 protein phosphatase 2A binding GO:0051721 9.26 BCL2 TP53
4 enzyme binding GO:0019899 9.26 BIRC5 ESR1 PGR TP53
5 MAP-kinase scaffold activity GO:0005078 8.62 MAPK8IP1 MAPK8IP2
6 protein binding GO:0005515 10.07 BCL2 BIRC5 ESR1 GP5 GP6 MAPK8IP1

Sources for Cervical Carcinosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....