MCID: CRV025
MIFTS: 37

Cervical Incompetence malady

Summaries for Cervical Incompetence

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards: Cervical Incompetence, also known as uterine cervical incompetence, is related to ehlers-danlos syndrome and cervicitis. An important gene associated with Cervical Incompetence is LEPRE1 (leucine proline-enriched proteoglycan (leprecan) 1), and among its related pathways are NCAM signaling for neurite out-growth and Degradation of collagen. Affiliated tissues include cervix, uterus and testes, and related mouse phenotypes are integument and skeleton.

Wikipedia:63 Cervical incompetence is a medical condition in which a pregnant woman\'s cervix begins to dilate... more...

Aliases & Classifications for Cervical Incompetence

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

cervical incompetence 8 10
uterine cervical incompetence 60


External Ids:

Disease Ontology8 DOID:9681
ICD9CM27 622.5
NCIt39 C50607
MeSH34 D002581

Related Diseases for Cervical Incompetence

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Cervical Incompetence:



Diseases related to cervical incompetence

Clinical Features for Cervical Incompetence

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Drugs & Therapeutics for Cervical Incompetence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Cervical Incompetence

Search CenterWatch for Cervical Incompetence

Genetic Tests for Cervical Incompetence

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Anatomical Context for Cervical Incompetence

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32MalaCards
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MalaCards organs/tissues related to Cervical Incompetence:

32
Cervix, Uterus, Testes, Placenta

Animal Models for Cervical Incompetence or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cervical Incompetence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.7COL5A1, COL5A2, TNXB, IL6, LEPRE1
2MP:00053907.6SERPINH1, LEPRE1, IL6, CRTAP, MFN2, COL5A2
3MP:00053787.3COL5A2, MFN2, CRTAP, IL6, LEPRE1, SERPINH1
4MP:00107687.2SERPINH1, IL6, MFN2, TNXB, COL5A2, COL5A1

Publications for Cervical Incompetence

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50PubMed
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Articles related to Cervical Incompetence:

(show top 50)    (show all 151)
idTitleAuthorsYear
1
Effective treatment of cervical incompetence in a monochorionic monoamniotic twin pregnancy with a rescue cervical cerclage and pessary--a case report and review of literature. (23488300)
2012
2
Cervical funneling after cerclage in cervical incompetence as a predictor of pregnancy outcome. (21463213)
2012
3
Cervical incompetence associated with congenital uterine malformations. (23700889)
2012
4
Association of very high Hungarian rate of preterm births with cervical incompetence in pregnant women. (20586224)
2010
5
Laparoscopic cervico-uterine cerclage using polypropylene mesh for the treatment of cervical incompetence. (16026416)
2005
6
Cervical incompetence and the role of emergency cerclage. (15937588)
2005
7
Interleukin-6, but not relaxin, predicts outcome of rescue cerclage in women with cervical incompetence. (15467541)
2004
8
Elective and emergency transabdominal cervicoisthmic cerclage for cervical incompetence. (12971139)
2003
9
Vaginal sonography and cervical incompetence. (12592276)
2003
10
Cervical incompetence prevention randomized cerclage trial: emergency cerclage with bed rest versus bed rest alone. (14586323)
2003
11
Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone. (11717642)
2001
12
Cervical incompetence: the use of selective and emergency cerclage. (11234614)
2001
13
Cervical incompetence prevention randomized cerclage trial (CIPRACT): study design and preliminary results. (11035320)
2000
14
Cervical epidural anesthesia for sub-total thyroidectomy in a patient with aortic incompetence. (10028799)
1998
15
Detection of pregnant women at risk of cervical incompetence by transvaginal sonography during straining. (9311176)
1997
16
The management of cervical incompetence with protruded membranes into the vagina by vaginal irrigation with granulocyte elastase inhibitor: ulinastatin and PVP-iodine solution. (15511764)
1997
17
Cervical collagen in non-pregnant women with previous cervical incompetence. (8789748)
1996
18
Cervical incompetence and cerclage: unresolved controversies. (7842551)
1994
19
Transvaginal sonography in the diagnosis and management of cervical incompetence. (8349181)
1993
20
Preterm labor, premature rupture of membranes, and cervical incompetence. (8425033)
1993
21
Preterm birth, premature rupture of membranes, and cervical incompetence. (1543827)
1992
22
Cervical incompetence: assessment of a scoring system for patient selection for cervical cerclage. (1674480)
1991
23
Cervical incompetence: preliminary evaluation with MR imaging. (2305065)
1990
24
Cervical incompetence: a 24-year review. (2898401)
1988
25
Value of ultrasound in patients with cervical incompetence. (2821776)
1987
26
The place of elective cerclage operation for cervical incompetence during pregnancy. (4087216)
1985
27
Cervical incompetence, hourglass membranes, and amniocentesis. (514562)
1979
28
Surgical correction of cervical incompetence. (45094)
1979
29
Relative cervical incompetence in twin pregnancy. Assessment and efficacy of cervical suture. (400212)
1979
30
The value of cervical cerclage in the treatment of cervical incompetence. (352990)
1978
31
Cervical incompetence: diagnostic and therapeutic aspects. (838569)
1977
32
Cervical incompetence and premature delivery after bromocriptine therapy for infertility. (69823)
1977
33
Cervical incompetence. A diagnostic and prognostic scoring system. (1250557)
1976
34
Editorial: Cervical incompetence. (4777549)
1973
35
Temporary submucosal cerclage for cervical incompetence: report of forty-eight cases. (4673775)
1972
36
Congenital cervical incompetence; report of a case. (5979500)
1966
37
Uterine rupture in labor following repair for cervical incompetence. (5916921)
1966
38
RESULTS OF SURGICAL TREATMENT IN 22 CASES OF CERVICAL INCOMPETENCE. (14288273)
1965
39
HABITUAL ABORTION CAUSED BY CERVICAL INCOMPETENCE: A SURGICAL STUDY. (14103494)
1964
40
Cervical incompetence. Difficulties encountered in the management and maintenance of pregnancy. (14471726)
1962
41
Cervical incompetence. (14464010)
1962
42
Cervical incompetence. A re-evaluation. (14024899)
1962
43
Cervical incompetence. (13750361)
1961
44
The physiology and clinical significance of the uterine isthmus. I. The two-stage intrauterine ballon in the diagnosis and treatment of cervical incompetence. (13766197)
1961
45
The role of the uterine isthmus in cervical incompetence. (13766198)
1960
46
Cervical incompetence: current therapy. (13795645)
1960
47
Cervical incompetence following high amputation. Report of a case of successful pregnancy following fascial repair. (14438387)
1960
48
The treatment of cervical incompetence. (13803541)
1959
49
Cervical incompetence and habitual abortion. (13526031)
1958
50
Occlusive trachelorrhaphy for repeated abortion due to cervical incompetence. (13282996)
1956

Genetic Variations for Cervical Incompetence

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Expression for genes affiliated with Cervical Incompetence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Incompetence

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Pathways for genes affiliated with Cervical Incompetence

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Cervical Incompetence

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GO Terms for genes affiliated with Cervical Incompetence

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16Gene Ontology
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Cellular components related to Cervical Incompetence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.3LEPRE1, CRTAP, TNXB
2collagen type VGO:0055888.9COL5A1, COL5A2
3extracellular matrixGO:0310128.3TNXB, COL5A2, COL5A1
4endoplasmic reticulum lumenGO:0057887.7SERPINH1, LEPRE1, CRTAP, COL5A2, COL5A1

Biological processes related to Cervical Incompetence according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cell growthGO:0160499.5IL6, LEPRE1
2extracellular fibril organizationGO:0432069.3TNXB, COL5A1
3collagen biosynthetic processGO:0329649.2COL5A1, SERPINH1
4eye morphogenesisGO:0485929.2COL5A2, COL5A1
5skin developmentGO:0435889.0COL5A2, COL5A1
6extracellular matrix disassemblyGO:0226179.0COL5A2, COL5A1
7collagen catabolic processGO:0305748.7COL5A2, COL5A1
8collagen fibril organizationGO:0301998.0SERPINH1, LEPRE1, TNXB, COL5A2, COL5A1
9extracellular matrix organizationGO:0301987.9COL5A1, COL5A2, CRTAP, LEPRE1, SERPINH1

Molecular functions related to Cervical Incompetence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen bindingGO:0055189.4SERPINH1, TNXB
2integrin bindingGO:0051789.2TNXB, COL5A1
3extracellular matrix structural constituentGO:0052018.7COL5A2, COL5A1

Products for genes affiliated with Cervical Incompetence

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Sources for Cervical Incompetence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet