MCID: CRV025
MIFTS: 34

Cervical Incompetence malady

Reproductive diseases category
Download this MalaCard

Summaries for Cervical Incompetence

About this section
Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards: Cervical Incompetence, also known as uterine cervical incompetence, is related to cervicitis and infertility. An important gene associated with Cervical Incompetence is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)). The compounds nitric oxide and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and testes, and related mouse phenotypes are skeleton and respiratory system.

Wikipedia:65 Cervical incompetence is a medical condition in which a pregnant woman\'s cervix begins to dilate... more...

Aliases & Classifications for Cervical Incompetence

About this section
Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

cervical incompetence 8 10
uterine cervical incompetence 62


External Ids:

Disease Ontology8 DOID:9681
ICD9CM27 622.5
NCIt40 C50607
MeSH35 D002581

Related Diseases for Cervical Incompetence

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cervical Incompetence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis11.1
2infertility10.2
3vaginitis10.2
4vulvovaginal candidiasis10.1
5ehlers-danlos syndrome10.1
6arthritis10.1IL6
7funisitis10.0SERPINH1
8chorioamnionitis10.0IL6, SERPINH1
9systemic lupus erythematosus10.0SERPINH1, IL6
10rheumatoid arthritis10.0IL6, SERPINH1
11primary hyperoxaluria10.0IL6, SERPINH1
12hypersensitivity reaction type ii disease9.9SERPINH1, IL6

Graphical network of diseases related to Cervical Incompetence:



Diseases related to cervical incompetence

Symptoms for Cervical Incompetence

About this section

Drugs & Therapeutics for Cervical Incompetence

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Cervical Incompetence

Search NIH Clinical Center for Cervical Incompetence

Genetic Tests for Cervical Incompetence

About this section

Anatomical Context for Cervical Incompetence

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cervical Incompetence:

33
Cervix, Uterus, Testes, Placenta

Animal Models for Cervical Incompetence or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Cervical Incompetence:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.1IL6, SERPINH1
2MP:00053889.0IL6, SERPINH1
3MP:00053818.8IL6, SERPINH1

Publications for Cervical Incompetence

About this section
Sources:
52PubMed
See all sources

Articles related to Cervical Incompetence:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Oxidative status shifts in uterine cervical incompetence patients. (24304328)
2013
2
Effective treatment of cervical incompetence in a monochorionic monoamniotic twin pregnancy with a rescue cervical cerclage and pessary--a case report and review of literature. (23488300)
2012
3
Effects of maternal cervical incompetence on morbidity and mortality of very low birthweight neonates. (20234141)
2010
4
Laparoscopic cervico-uterine cerclage using polypropylene mesh for the treatment of cervical incompetence. (16026416)
2005
5
Cervical incompetence and the role of emergency cerclage. (15937588)
2005
6
Management of cervical incompetence in Aba, south-eastern Nigeria. (16353700)
2005
7
A five century evolution of cervical incompetence as a clinical entity. (15777226)
2005
8
Complications of cervical cerclage in women with cervical incompetence. (14643041)
2003
9
Elective and emergency transabdominal cervicoisthmic cerclage for cervical incompetence. (12971139)
2003
10
Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone. (11717642)
2001
11
Cervical incompetence: the use of transvaginal sonography to provide an objective diagnosis. (11555448)
2001
12
Cervical incompetence: elective, emergent, or urgent cerclage. (10454663)
1999
13
Emergency cervical circlage for cervical incompetence. (15511765)
1997
14
Treatment of cervical incompetence by transabdominal cervicoisthmic cerclage. (9429702)
1997
15
Emergency cervical cerclage for cervical incompetence. (15511978)
1997
16
Transabdominal cervico-isthmic cerclage in the management of cervical incompetence. (9134389)
1997
17
Transvaginal ultrasound in the management of women with suspected cervical incompetence. (8813314)
1996
18
Cervical cerclage in the treatment of cervical incompetence in Zambian women. (9001790)
1996
19
Validity of indications for transabdominal cervicoisthmic cerclage for cervical incompetence. (7778646)
1995
20
Transvaginal sonography in the diagnosis and management of cervical incompetence. (8349181)
1993
21
Cervical incompetence: assessment of a scoring system for patient selection for cervical cerclage. (1674480)
1991
22
Cervical incompetence: preliminary evaluation with MR imaging. (2305065)
1990
23
Value of ultrasound in patients with cervical incompetence. (2821776)
1987
24
Negative sonographic findings followed by rapid cervical dilatation due to cervical incompetence. (3885104)
1985
25
The place of elective cerclage operation for cervical incompetence during pregnancy. (4087216)
1985
26
Negative sonographic findings followed by rapid cervical dilatation due to cervical incompetence. (6738939)
1984
27
The validity of real time scanning in detection of the cervical incompetence. (6400537)
1984
28
Stress relaxation of the human cervix: a new tool for diagnosis of cervical incompetence. (6488727)
1984
29
Nonsurgical treatment of cervical incompetence. (6140772)
1983
30
The influence of progesterone treatment on the course and outcome of pregnancies following suture of the cervix for cervical incompetence. (7307264)
1981
31
Cervical incompetence, 1980: a time for reappraisal. (6994969)
1980
32
Cervical incompetence: diagnostic and therapeutic aspects. (838569)
1977
33
Management of cervical incompetence with cerclage according to Shirodkar. A report on 110 cases]. (961327)
1976
34
Cervical incompetence. A diagnostic and prognostic scoring system. (1250557)
1976
35
Letter: prostaglandin-induced abortion and cervical incompetence. (1148669)
1975
36
Cervical incompetence: aetiology and management. (4591301)
1973
37
Shirodkar suture for cervical incompetence. (4574407)
1973
38
Cervical incompetence in multiple pregnancy. (5438149)
1970
39
Surgical treatment of cervical incompetence during pregnancy. (5418097)
1970
40
Management of cervical incompetence. (5347310)
1969
41
Cervical incompetence: surgical treatment of twenty-four cases during pregnancy. (6079200)
1967
42
Cerclage for cervical incompetence. (5337684)
1967
43
Congenital cervical incompetence; report of a case. (5979500)
1966
44
HABITUAL ABORTION CAUSED BY CERVICAL INCOMPETENCE: A SURGICAL STUDY. (14103494)
1964
45
THE MANAGEMENT OF CERVICAL INCOMPETENCE BY PURSE-STRING SUTURE. (14072415)
1963
46
Cervical incompetence. Difficulties encountered in the management and maintenance of pregnancy. (14471726)
1962
47
Cervical incompetence. (14464010)
1962
48
Subsequent obstetrical performance of patients meeting the historical criteria for cervical incompetence. (13725052)
1961
49
Cervical incompetence and habitual abortion. (13526031)
1958
50
Occlusive trachelorrhaphy for repeated abortion due to cervical incompetence. (13282996)
1956

Variations for Cervical Incompetence

About this section

Expression for genes affiliated with Cervical Incompetence

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cervical Incompetence

Search GEO for disease gene expression data for Cervical Incompetence.

Pathways for genes affiliated with Cervical Incompetence

About this section

Compounds for genes affiliated with Cervical Incompetence

About this section
Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience
See all sources

Compounds related to Cervical Incompetence according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1nitric oxide45 24 1111.1IL6, SERPINH1
2cyclosporin a45 29 6111.0IL6, SERPINH1
3vegf458.8IL6, SERPINH1

GO Terms for genes affiliated with Cervical Incompetence

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cervical Incompetence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1IL6, SERPINH1

Products for genes affiliated with Cervical Incompetence

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cervical Incompetence

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet