MCID: CRV025
MIFTS: 39

Cervical Incompetence

Categories: Reproductive diseases

Aliases & Classifications for Cervical Incompetence

MalaCards integrated aliases for Cervical Incompetence:

Name: Cervical Incompetence 12 14
Uterine Cervical Incompetence 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9681
ICD10 32 N88.3
ICD9CM 34 622.5
MeSH 41 D002581
NCIt 46 C50607
UMLS 69 C0007871

Summaries for Cervical Incompetence

Disease Ontology : 12 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards based summary : Cervical Incompetence, also known as uterine cervical incompetence, is related to vaginitis and ehlers-danlos syndrome. An important gene associated with Cervical Incompetence is IL6 (Interleukin 6), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Misoprostol and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and placenta, and related phenotypes are limbs/digits/tail and skeleton

Wikipedia : 72 Cervical incompetence (or cervical insufficiency) is a medical condition of pregnancy in which the... more...

Related Diseases for Cervical Incompetence

Graphical network of the top 20 diseases related to Cervical Incompetence:



Diseases related to Cervical Incompetence

Symptoms & Phenotypes for Cervical Incompetence

MGI Mouse Phenotypes related to Cervical Incompetence:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.26 HOXA11 P3H1 PLOD1 SERPINH1
2 skeleton MP:0005390 9.17 COL5A2 CRTAP HOXA11 IL6 P3H1 PLOD1

Drugs & Therapeutics for Cervical Incompetence

Drugs for Cervical Incompetence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Misoprostol Approved Phase 4,Phase 3 59122-46-2 5282381
2
Dinoprostone Approved Phase 4 363-24-6 5280360
3
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
4
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Chloroprocaine Approved Phase 4 133-16-4 8612
7 Gastrointestinal Agents Phase 4,Phase 3
8 Oxytocics Phase 4,Phase 3
9 Antacids Phase 4,Phase 3
10 Anti-Ulcer Agents Phase 4,Phase 3
11 Analgesics Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Central Nervous System Depressants Phase 4
14 Adjuvants, Anesthesia Phase 4
15 Narcotics Phase 4
16 Analgesics, Opioid Phase 4
17 Anesthetics Phase 4
18 Anesthetics, General Phase 4
19 Anesthetics, Intravenous Phase 4
20 Anesthetics, Local Phase 4
21 Pharmaceutical Solutions Phase 4
22
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
23
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
24
Silicon Approved, Investigational Phase 3 7440-21-3 4082203
25 Contraceptive Agents Phase 3
26 Contraceptives, Oral Phase 3
27 Contraceptives, Postcoital Phase 3
28 Hormone Antagonists Phase 3,Phase 2
29 Hormones Phase 3,Phase 2
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
31 Luteolytic Agents Phase 3
32 Progestins Phase 2, Phase 3
33
Menthol Approved 2216-51-5 16666
34
Indomethacin Approved, Investigational 53-86-1 3715
35
Cefazolin Approved 25953-19-9 33255 656510
36
Clindamycin Approved, Vet_approved 18323-44-9 29029
37
Acetylcysteine Approved, Investigational 616-91-1 12035
38
Lidocaine Approved, Vet_approved 137-58-6 3676
39 Respiratory System Agents
40 N-monoacetylcystine
41 Clindamycin palmitate
42 Clindamycin phosphate
43 Tocolytic Agents
44 Cyclooxygenase Inhibitors
45 Analgesics, Non-Narcotic
46 Anti-Bacterial Agents
47 Antidotes
48 Anti-Infective Agents
49 Expectorants
50 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 Intravaginal Misoprostol Versus Dinoprostone Before Diagnostik Hysteroscopy Unknown status NCT01620814 Phase 4 Dinoprostone;misoprostol;control
2 Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Recruiting NCT03305575 Phase 4 Chloroprocaine;Bupivacaine
3 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Recruiting NCT02862912 Phase 4 Chloroprocaine;Bupivacaine;Fentanyl;Saline
4 Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination Unknown status NCT01795599 Phase 3 Mifegyne ®;Gymiso®
5 Physical Examination-Indicated Pessary Recruiting NCT02967445 Phase 3
6 Cerclage for Twins With Short Cervix Withdrawn NCT03077633 Phase 2, Phase 3 Vaginal Progesterone
7 The Effect of Adjunctive Use of Vaginal Progesterone After Cerclage on Prevention of 2nd Trimester Miscarriage Recruiting NCT02846909 Phase 2 Progesterone
8 Patient Attitudes Toward Ultrasound Measurement of Cervical Length Unknown status NCT01482039
9 Preventing Preterm Birth With a Pessary Unknown status NCT01380158
10 Multifactorial Approach to Emergent Cerclage Completed NCT01114516 Indomethacin and antibiotics (cefazolin or clindamycin)
11 Dilapan-S Osmotic Dilator in Pre-induction of Labor Completed NCT02098382
12 N-Acetyl Cysteine After Cervical Cerclage Completed NCT00787813 N-Acetyl Cysteine;Placebo
13 The Biomarker Study Completed NCT01148654
14 Amniotic Fluid Sludge in Cerclage Patients as an Indicator for Increased Risk of Preterm Delivery and Neonatal Outcome. Completed NCT00722085
15 Cerclage vs Cervical Pessary in Women With Cervical Incompetence Recruiting NCT02405455
16 Use of Pessary in Case of Cervical Insufficiency and Short Cervix Recruiting NCT03096691
17 Prolene Versus Ethibond for Cervical Cerclage Recruiting NCT03311867
18 CellulaR Injury and Preterm Birth Recruiting NCT02441335
19 Prevention of Preterm Birth in Singletons Using Pessary After Resolutive Threatened Preterm Labor Recruiting NCT02484820
20 The Impact of Cervical Cerclage or Vaginal Progesterone on Vaginal Microbiome Distribution Recruiting NCT03253016
21 Maternal Gut Microbiome (MGM) Study of Diet, the Gut Microbiome and Preterm Birth Recruiting NCT02560246
22 Cervical Occlusion for the Prevention of Preterm Birth Terminated NCT01737788
23 Determination of ED90 of Intrathecal Lidocaine for Adequate Anesthesia for Elective Cervical Cerclage Surgery Terminated NCT02574832 Lidocaine Administration

Search NIH Clinical Center for Cervical Incompetence

Cochrane evidence based reviews: uterine cervical incompetence

Genetic Tests for Cervical Incompetence

Anatomical Context for Cervical Incompetence

MalaCards organs/tissues related to Cervical Incompetence:

38
Cervix, Uterus, Placenta, Testes

Publications for Cervical Incompetence

Articles related to Cervical Incompetence:

(show top 50) (show all 160)
# Title Authors Year
1
Don't be short-sighted: cervical incompetence in a pregnant patient with acute appendicitis. ( 29414522 )
2018
2
The place for prophylactic cerclage in the infertile patient with established cervical incompetence who conceived twins after septum reduction. ( 29209482 )
2017
3
Role of Cervical Cerclage and Vaginal Progesterone in the Treatment of Cervical Incompetence with/without Preterm Birth History. ( 27823998 )
2016
4
EP18.11: Prenatal diagnosis of caput succedaneum associated with cervical incompetence at 16 weeks. ( 27647484 )
2016
5
Co-morbidity of cervical incompetence with polycystic ovarian syndrome (PCOS) negatively impacts prognosis: A retrospective analysis of 178 patients. ( 27733131 )
2016
6
Laparoscopic Cerclage for Prevention of Recurrent Pregnancy Loss Due to Cervical Incompetence. ( 27679035 )
2015
7
Successful delivery after transabdominal cerclage of uterine cervix for cervical incompetence after radical trachelectomy. ( 25944172 )
2015
8
Effects of Maternal Cervical Incompetence on Morbidity and Mortality of Preterm Neonates with Birth weight Less than 2000g. ( 26019783 )
2014
9
Successful treatment of cervical incompetence using a modified laparoscopic cervical cerclage technique: a cohort study. ( 24965992 )
2014
10
Oxidative status shifts in uterine cervical incompetence patients. ( 24304328 )
2013
11
Use of cervical cerclage as a treatment option for cervical incompetence: patient characteristics, presentation and management over a 9 year period in a Kenyan centre. ( 24069746 )
2013
12
Effective treatment of cervical incompetence in a monochorionic monoamniotic twin pregnancy with a rescue cervical cerclage and pessary--a case report and review of literature. ( 23488300 )
2012
13
Cervical funneling after cerclage in cervical incompetence as a predictor of pregnancy outcome. ( 21463213 )
2012
14
Cervical incompetence associated with congenital uterine malformations. ( 23700889 )
2012
15
Pregnancy outcome after cerclage for cervical incompetence at the University of Port Harcourt Teaching Hospital, Port Harcourt. ( 23437511 )
2012
16
Laparoscopic cervicoisthmic cerclage for the treatment of cervical incompetence: case reports. ( 22519240 )
2011
17
Ambispective study on Mac Donald suturing in pregnant ladies with cervical incompetence in Dhulikhel Hospital. ( 22610738 )
2010
18
Effects of maternal cervical incompetence on morbidity and mortality of very low birthweight neonates. ( 20234141 )
2010
19
Association of very high Hungarian rate of preterm births with cervical incompetence in pregnant women. ( 20586224 )
2010
20
Pessary use for the treatment of cervical incompetence and prevention of preterm labour. ( 20334532 )
2010
21
Uterine Didelphys with Pregnancy and Cervical Incompetence. ( 27407898 )
2006
22
Noninvasive cerclage for the management of cervical incompetence: a prospective study. ( 16222537 )
2006
23
Laparoscopic cervico-uterine cerclage using polypropylene mesh for the treatment of cervical incompetence. ( 16026416 )
2005
24
Cervical incompetence and the role of emergency cerclage. ( 15937588 )
2005
25
Management of cervical incompetence in Aba, south-eastern Nigeria. ( 16353700 )
2005
26
A five century evolution of cervical incompetence as a clinical entity. ( 15777226 )
2005
27
Controversies regarding cervical incompetence, short cervix, and the need for cerclage. ( 15519424 )
2004
28
Interleukin-6, but not relaxin, predicts outcome of rescue cerclage in women with cervical incompetence. ( 15467541 )
2004
29
Preterm deliveries among women with MacDonald cerclage performed due to cervical incompetence. ( 15192297 )
2004
30
Cervical surveillance as an alternative to elective cervical cerclage for pregnancy management of suspected cervical incompetence. ( 15191447 )
2004
31
Cervical incompetence prevention randomized cerclage trial: emergency cerclage with bed rest versus bed rest alone. ( 14586323 )
2003
32
Complications of cervical cerclage in women with cervical incompetence. ( 14643041 )
2003
33
Elective and emergency transabdominal cervicoisthmic cerclage for cervical incompetence. ( 12971139 )
2003
34
Diagnostic features of cervical incompetence among women in Maiduguri. ( 12745553 )
2003
35
Vaginal sonography and cervical incompetence. ( 12592276 )
2003
36
Cervical incompetence: a reappraisal of an obstetric controversy. ( 12140372 )
2002
37
Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): effect of therapeutic cerclage with bed rest vs. bed rest only on cervical length. ( 12153667 )
2002
38
Hematometra after thermal balloon endometrial ablation in a patient with cervical incompetence. ( 11642669 )
2001
39
Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone. ( 11717642 )
2001
40
Cervical incompetence: the use of transvaginal sonography to provide an objective diagnosis. ( 11555448 )
2001
41
Cervical incompetence: the use of selective and emergency cerclage. ( 11234614 )
2001
42
The value of transvaginal ultrasonography in diagnosis and management of cervical incompetence. ( 11838756 )
2001
43
Cervical incompetence prevention randomized cerclage trial (CIPRACT): study design and preliminary results. ( 11035320 )
2000
44
Cervical incompetence: elective, emergent, or urgent cerclage. ( 10454663 )
1999
45
MRI appearance of cervical incompetence in a pregnant patient. ( 10576725 )
1999
46
The epidemiology of cervical incompetence in Ramathibodi Hospital between 1982-1997. ( 10511780 )
1999
47
Can examination of the cervix provide useful information for prediction of cervical incompetence and following preterm labour? ( 10554937 )
1999
48
Diagnostic imaging in cervical incompetence. ( 10191659 )
1998
49
A comparison of ultrasonographically detected cervical changes in response to transfundal pressure, coughing, and standing in predicting cervical incompetence. ( 9322639 )
1997
50
Transvaginal ultrasound in the management of women with suspected cervical incompetence. ( 9091023 )
1997

Variations for Cervical Incompetence

Expression for Cervical Incompetence

Search GEO for disease gene expression data for Cervical Incompetence.

Pathways for Cervical Incompetence

GO Terms for Cervical Incompetence

Cellular components related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.62 CRTAP P3H1 PLOD1 SERPINH1
2 proteinaceous extracellular matrix GO:0005578 9.33 COL5A2 CRTAP P3H1
3 collagen trimer GO:0005581 9.26 COL5A2 SERPINH1
4 endoplasmic reticulum lumen GO:0005788 9.02 COL5A2 CRTAP IL6 P3H1 SERPINH1
5 macromolecular complex GO:0032991 8.96 CRTAP P3H1

Biological processes related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bone development GO:0060348 9.26 HOXA11 P3H1
2 chaperone-mediated protein folding GO:0061077 9.16 CRTAP P3H1
3 collagen fibril organization GO:0030199 8.96 COL5A2 SERPINH1
4 negative regulation of post-translational protein modification GO:1901874 8.62 CRTAP P3H1

Molecular functions related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dioxygenase activity GO:0051213 9.26 P3H1 PLOD1
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.16 P3H1 PLOD1
3 collagen binding GO:0005518 8.96 P3H1 SERPINH1
4 L-ascorbic acid binding GO:0031418 8.62 P3H1 PLOD1

Sources for Cervical Incompetence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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