MCID: CRV025
MIFTS: 34

Cervical Incompetence malady

Summaries for Cervical Incompetence

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards: Cervical Incompetence, also known as uterine cervical incompetence, is related to infertility and vulvovaginal candidiasis. An important gene associated with Cervical Incompetence is LEPRE1 (leucine proline-enriched proteoglycan (leprecan) 1), and among its related pathways are NCAM signaling for neurite out-growth and Degradation of collagen. Affiliated tissues include placenta and cervix, and related mouse phenotypes are integument and skeleton.

Wikipedia:64 Cervical incompetence is a medical condition in which a pregnant woman\'s cervix begins to dilate... more...

Aliases & Classifications for Cervical Incompetence

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

cervical incompetence 8 10
uterine cervical incompetence 61


External Ids:

Disease Ontology8 DOID:9681
ICD9CM27 622.5
NCIt40 C50607
MeSH35 D002581

Related Diseases for Cervical Incompetence

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Cervical Incompetence:



Diseases related to cervical incompetence

Clinical Features for Cervical Incompetence

Drugs & Therapeutics for Cervical Incompetence

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cervical Incompetence

Drug clinical trials:

Search ClinicalTrials for Cervical Incompetence

Search NIH Clinical Center for Cervical Incompetence

Search CenterWatch for Cervical Incompetence

Genetic Tests for Cervical Incompetence

Anatomical Context for Cervical Incompetence

Sources:
33MalaCards
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MalaCards organs/tissues related to Cervical Incompetence:

33
Placenta, Cervix

Animal Models for Cervical Incompetence or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Cervical Incompetence:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.7LEPRE1, IL6, TNXB, COL5A2, COL5A1
2MP:00053907.6COL5A2, CRTAP, IL6, LEPRE1, SERPINH1, MFN2
3MP:00053787.3COL5A2, LEPRE1, IL6, CRTAP, MFN2, SERPINH1
4MP:00107687.2COL5A2, TNXB, MFN2, IL6, SERPINH1, COL5A1

Publications for Cervical Incompetence

Sources:
51PubMed
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Articles related to Cervical Incompetence:

(show top 50)    (show all 152)
idTitleAuthorsYear
1
Use of cervical cerclage as a treatment option for cervical incompetence: patient characteristics, presentation and management over a 9 year period in a Kenyan centre. (24069746)
2013
2
Ambispective study on Mac Donald suturing in pregnant ladies with cervical incompetence in Dhulikhel Hospital. (22610738)
2010
3
Laparoscopic cervico-uterine cerclage using polypropylene mesh for the treatment of cervical incompetence. (16026416)
2005
4
Interleukin-6, but not relaxin, predicts outcome of rescue cerclage in women with cervical incompetence. (15467541)
2004
5
Complications of cervical cerclage in women with cervical incompetence. (14643041)
2003
6
Vaginal sonography and cervical incompetence. (12592276)
2003
7
Diagnostic features of cervical incompetence among women in Maiduguri. (12745553)
2003
8
Hematometra after thermal balloon endometrial ablation in a patient with cervical incompetence. (11642669)
2001
9
Cervical incompetence: elective, emergent, or urgent cerclage. (10454663)
1999
10
Can examination of the cervix provide useful information for prediction of cervical incompetence and following preterm labour? (10554937)
1999
11
MRI appearance of cervical incompetence in a pregnant patient. (10576725)
1999
12
The epidemiology of cervical incompetence in Ramathibodi Hospital between 1982-1997. (10511780)
1999
13
Detection of pregnant women at risk of cervical incompetence by transvaginal sonography during straining. (9311176)
1997
14
Maternal postural challenge as a functional test for cervical incompetence. (9166812)
1997
15
Transvaginal ultrasound in the management of women with suspected cervical incompetence. (9091022)
1997
16
Outcome of second-trimester, emergency cervical cerclage in patients with no history of cervical incompetence. (8960611)
1996
17
Transvaginal ultrasound in the management of women with suspected cervical incompetence. (8813314)
1996
18
Cervical collagen in non-pregnant women with previous cervical incompetence. (8789748)
1996
19
Preterm labor, premature rupture of membranes, and cervical incompetence. (8425033)
1993
20
Interval evaluation of the cervix for predicting pregnancy outcome and diagnosing cervical incompetence. (8320673)
1993
21
Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance. (1415396)
1992
22
A simple scoring system for the treatment of cervical incompetence diagnosed during the second trimester. (2010110)
1991
23
Transabdominal cerclage for fetal wastage due to cervical incompetence. (3285265)
1988
24
Value of ultrasound in patients with cervical incompetence. (2821776)
1987
25
Ultrasonic evaluation of cervical incompetence. (3513849)
1986
26
Successful use of transabdominal isthmic cerclage in the management of cervical incompetence. (3533673)
1986
27
Negative sonographic findings followed by rapid cervical dilatation due to cervical incompetence. (3885104)
1985
28
The place of elective cerclage operation for cervical incompetence during pregnancy. (4087216)
1985
29
The management of cervical incompetence in late pregnancy. Report of 2 cases. (4012479)
1985
30
Negative sonographic findings followed by rapid cervical dilatation due to cervical incompetence. (6738939)
1984
31
The validity of real time scanning in detection of the cervical incompetence. (6400537)
1984
32
Detection of cervical incompetence by ultrasound. (6388222)
1984
33
Ultrasonography in the diagnosis of cervical incompetence in pregnancy-a new diagnostic approach. (7248221)
1981
34
Cervical incompetence, hourglass membranes, and amniocentesis. (514562)
1979
35
Surgical correction of cervical incompetence. (45094)
1979
36
The value of cervical cerclage in the treatment of cervical incompetence. (352990)
1978
37
Cervical incompetence. (567428)
1978
38
Letter: prostaglandin-induced abortion and cervical incompetence. (1148669)
1975
39
Letter: Cervical incompetence. (4419859)
1974
40
Shirodkar suture for cervical incompetence. (4574407)
1973
41
Temporary submucosal cerclage for cervical incompetence: report of forty-eight cases. (4673775)
1972
42
Triplet pregnancy and cervical incompetence. A case report. (4644559)
1972
43
The problem of cervical incompetence in Malaysian women. (4268034)
1972
44
Cervical incompetence: surgical treatment of twenty-four cases during pregnancy. (6079200)
1967
45
Cervical incompetence. (6046410)
1967
46
Congenital cervical incompetence; report of a case. (5979500)
1966
47
HABITUAL ABORTION CAUSED BY CERVICAL INCOMPETENCE: A SURGICAL STUDY. (14103494)
1964
48
The physiology and clinical significance of the uterine isthmus. I. The two-stage intrauterine ballon in the diagnosis and treatment of cervical incompetence. (13766197)
1961
49
The role of the uterine isthmus in cervical incompetence. (13766198)
1960
50
Cervical incompetence and habitual abortion. (13526031)
1958

Genetic Variations for Cervical Incompetence

Expression for genes affiliated with Cervical Incompetence

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Incompetence

Search GEO for disease gene expression data for Cervical Incompetence.

Pathways for genes affiliated with Cervical Incompetence

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN
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Compounds for genes affiliated with Cervical Incompetence

GO Terms for genes affiliated with Cervical Incompetence

Sources:
16Gene Ontology
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Cellular components related to Cervical Incompetence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.3TNXB, CRTAP, LEPRE1
2collagen type VGO:0055888.9COL5A2, COL5A1
3extracellular matrixGO:0310128.3COL5A2, TNXB, COL5A1
4endoplasmic reticulum lumenGO:0057887.7LEPRE1, SERPINH1, COL5A1, CRTAP, COL5A2

Biological processes related to Cervical Incompetence according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cell growthGO:0160499.5IL6, LEPRE1
2extracellular fibril organizationGO:0432069.3TNXB, COL5A1
3collagen biosynthetic processGO:0329649.2COL5A1, SERPINH1
4eye morphogenesisGO:0485929.2COL5A2, COL5A1
5skin developmentGO:0435889.0COL5A2, COL5A1
6extracellular matrix disassemblyGO:0226179.0COL5A2, COL5A1
7collagen catabolic processGO:0305748.7COL5A2, COL5A1
8collagen fibril organizationGO:0301998.0SERPINH1, LEPRE1, TNXB, COL5A2, COL5A1
9extracellular matrix organizationGO:0301987.9COL5A1, COL5A2, CRTAP, LEPRE1, SERPINH1

Molecular functions related to Cervical Incompetence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen bindingGO:0055189.4SERPINH1, TNXB
2integrin bindingGO:0051789.2TNXB, COL5A1
3extracellular matrix structural constituentGO:0052018.7COL5A2, COL5A1

Products for genes affiliated with Cervical Incompetence

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Sources for Cervical Incompetence

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet