MCID: CRV025
MIFTS: 34

Cervical Incompetence malady

Reproductive diseases category
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Summaries for Cervical Incompetence

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Disease Ontology:8 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards based summary: Cervical Incompetence, also known as uterine cervical incompetence, is related to cervicitis and arthritis. An important gene associated with Cervical Incompetence is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)). The compounds nitric oxide and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and placenta, and related mouse phenotypes are skeleton and respiratory system.

Wikipedia:65 Cervical incompetence or (cervical insufficiency) is a medical condition in which a pregnant woman\'s... more...

Aliases & Classifications for Cervical Incompetence

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Cervical Incompetence, Aliases & Descriptions:

Name: Cervical Incompetence 8 10
 
Uterine Cervical Incompetence 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:9681
MeSH34 D002581
NCIt39 C50607
ICD9CM27 622.5

Related Diseases for Cervical Incompetence

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Diseases related to Cervical Incompetence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis11.2
2arthritis10.2IL6
3infertility10.2
4vaginitis10.2
5funisitis10.2SERPINH1
6vulvovaginal candidiasis10.1
7ehlers-danlos syndrome10.1
8chorioamnionitis9.9IL6, SERPINH1
9systemic lupus erythematosus9.9SERPINH1, IL6
10rheumatoid arthritis9.9IL6, SERPINH1
11primary hyperoxaluria9.8IL6, SERPINH1
12hypersensitivity reaction type ii disease9.8SERPINH1, IL6

Graphical network of diseases related to Cervical Incompetence:



Diseases related to cervical incompetence

Symptoms for Cervical Incompetence

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Drugs & Therapeutics for Cervical Incompetence

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Drug clinical trials:

Search ClinicalTrials for Cervical Incompetence

Search NIH Clinical Center for Cervical Incompetence

Genetic Tests for Cervical Incompetence

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Anatomical Context for Cervical Incompetence

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MalaCards organs/tissues related to Cervical Incompetence:

32
Cervix, Uterus, Placenta, Testes

Animal Models for Cervical Incompetence or affiliated genes

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MGI Mouse Phenotypes related to Cervical Incompetence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.1IL6, SERPINH1
2MP:00053889.0IL6, SERPINH1
3MP:00053818.8IL6, SERPINH1

Publications for Cervical Incompetence

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Articles related to Cervical Incompetence:

(show top 50)    (show all 150)
idTitleAuthorsYear
1
Successful treatment of cervical incompetence using a modified laparoscopic cervical cerclage technique: a cohort study. (24965992)
2014
2
Oxidative status shifts in uterine cervical incompetence patients. (24304328)
2013
3
Effective treatment of cervical incompetence in a monochorionic monoamniotic twin pregnancy with a rescue cervical cerclage and pessary--a case report and review of literature. (23488300)
2012
4
Effects of maternal cervical incompetence on morbidity and mortality of very low birthweight neonates. (20234141)
2010
5
Laparoscopic cervico-uterine cerclage using polypropylene mesh for the treatment of cervical incompetence. (16026416)
2005
6
Cervical incompetence and the role of emergency cerclage. (15937588)
2005
7
Management of cervical incompetence in Aba, south-eastern Nigeria. (16353700)
2005
8
A five century evolution of cervical incompetence as a clinical entity. (15777226)
2005
9
Complications of cervical cerclage in women with cervical incompetence. (14643041)
2003
10
Elective and emergency transabdominal cervicoisthmic cerclage for cervical incompetence. (12971139)
2003
11
Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone. (11717642)
2001
12
Cervical incompetence: the use of transvaginal sonography to provide an objective diagnosis. (11555448)
2001
13
Cervical incompetence: elective, emergent, or urgent cerclage. (10454663)
1999
14
Emergency cervical circlage for cervical incompetence. (15511765)
1997
15
Treatment of cervical incompetence by transabdominal cervicoisthmic cerclage. (9429702)
1997
16
Emergency cervical cerclage for cervical incompetence. (15511978)
1997
17
Outcome of second-trimester, emergency cervical cerclage in patients with no history of cervical incompetence. (8960611)
1996
18
Transvaginal ultrasound in the management of women with suspected cervical incompetence. (8813314)
1996
19
Cervical cerclage in the treatment of cervical incompetence in Zambian women. (9001790)
1996
20
Validity of indications for transabdominal cervicoisthmic cerclage for cervical incompetence. (7778646)
1995
21
Transvaginal sonography in the diagnosis and management of cervical incompetence. (8349181)
1993
22
Cervical incompetence: assessment of a scoring system for patient selection for cervical cerclage. (1674480)
1991
23
Cervical incompetence: preliminary evaluation with MR imaging. (2305065)
1990
24
Value of ultrasound in patients with cervical incompetence. (2821776)
1987
25
Negative sonographic findings followed by rapid cervical dilatation due to cervical incompetence. (3885104)
1985
26
The place of elective cerclage operation for cervical incompetence during pregnancy. (4087216)
1985
27
Negative sonographic findings followed by rapid cervical dilatation due to cervical incompetence. (6738939)
1984
28
The validity of real time scanning in detection of the cervical incompetence. (6400537)
1984
29
Stress relaxation of the human cervix: a new tool for diagnosis of cervical incompetence. (6488727)
1984
30
Nonsurgical treatment of cervical incompetence. (6140772)
1983
31
The influence of progesterone treatment on the course and outcome of pregnancies following suture of the cervix for cervical incompetence. (7307264)
1981
32
Cervical incompetence, 1980: a time for reappraisal. (6994969)
1980
33
Cervical incompetence: diagnostic and therapeutic aspects. (838569)
1977
34
Management of cervical incompetence with cerclage according to Shirodkar. A report on 110 cases]. (961327)
1976
35
Cervical incompetence. A diagnostic and prognostic scoring system. (1250557)
1976
36
Letter: prostaglandin-induced abortion and cervical incompetence. (1148669)
1975
37
Cervical incompetence: aetiology and management. (4591301)
1973
38
Cervical incompetence in multiple pregnancy. (5438149)
1970
39
Surgical treatment of cervical incompetence during pregnancy. (5418097)
1970
40
Management of cervical incompetence. (5347310)
1969
41
Cervical incompetence: surgical treatment of twenty-four cases during pregnancy. (6079200)
1967
42
Cerclage for cervical incompetence. (5337684)
1967
43
Congenital cervical incompetence; report of a case. (5979500)
1966
44
HABITUAL ABORTION CAUSED BY CERVICAL INCOMPETENCE: A SURGICAL STUDY. (14103494)
1964
45
THE MANAGEMENT OF CERVICAL INCOMPETENCE BY PURSE-STRING SUTURE. (14072415)
1963
46
Cervical incompetence. Difficulties encountered in the management and maintenance of pregnancy. (14471726)
1962
47
Cervical incompetence. (14464010)
1962
48
Subsequent obstetrical performance of patients meeting the historical criteria for cervical incompetence. (13725052)
1961
49
Cervical incompetence and habitual abortion. (13526031)
1958
50
Occlusive trachelorrhaphy for repeated abortion due to cervical incompetence. (13282996)
1956

Variations for Cervical Incompetence

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Expression for genes affiliated with Cervical Incompetence

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Expression patterns in normal tissues for genes affiliated with Cervical Incompetence

Search GEO for disease gene expression data for Cervical Incompetence.

Pathways for genes affiliated with Cervical Incompetence

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Compounds for genes affiliated with Cervical Incompetence

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 61Tocris Bioscience
See all sources

Compounds related to Cervical Incompetence according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1nitric oxide44 24 1111.1IL6, SERPINH1
2cyclosporin a44 28 6111.0IL6, SERPINH1
3vegf448.8IL6, SERPINH1

GO Terms for genes affiliated with Cervical Incompetence

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Cellular components related to Cervical Incompetence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1IL6, SERPINH1

Products for genes affiliated with Cervical Incompetence

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Sources for Cervical Incompetence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet