MCID: CRV025
MIFTS: 37

Cervical Incompetence malady

Summaries for Cervical Incompetence

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards: Cervical Incompetence, also known as uterine cervical incompetence, is related to ehlers-danlos syndrome and cervicitis. An important gene associated with Cervical Incompetence is LEPRE1 (leucine proline-enriched proteoglycan (leprecan) 1), and among its related pathways are NCAM signaling for neurite out-growth and Degradation of collagen. Affiliated tissues include cervix, uterus and placenta, and related mouse phenotypes are integument and skeleton.

Wikipedia:63 Cervical incompetence is a medical condition in which a pregnant woman\'s cervix begins to dilate... more...

Aliases & Classifications for Cervical Incompetence

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

cervical incompetence 8 10
uterine cervical incompetence 60


External Ids:

Disease Ontology8 DOID:9681
ICD9CM27 622.5
NCIt39 C50607
MeSH34 D002581

Related Diseases for Cervical Incompetence

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Cervical Incompetence:



Diseases related to cervical incompetence

Clinical Features for Cervical Incompetence

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Drugs & Therapeutics for Cervical Incompetence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Cervical Incompetence

Search CenterWatch for Cervical Incompetence

Genetic Tests for Cervical Incompetence

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Anatomical Context for Cervical Incompetence

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32MalaCards
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MalaCards organs/tissues related to Cervical Incompetence:

32
Cervix, Uterus, Placenta, Testes

Animal Models for Cervical Incompetence or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cervical Incompetence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.7COL5A1, COL5A2, TNXB, IL6, LEPRE1
2MP:00053907.6SERPINH1, LEPRE1, IL6, CRTAP, MFN2, COL5A2
3MP:00053787.3COL5A2, MFN2, CRTAP, IL6, LEPRE1, SERPINH1
4MP:00107687.2SERPINH1, IL6, MFN2, TNXB, COL5A2, COL5A1

Publications for Cervical Incompetence

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50PubMed
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Articles related to Cervical Incompetence:

(show top 50)    (show all 151)
idTitleAuthorsYear
1
Oxidative status shifts in uterine cervical incompetence patients. (24304328)
2013
2
Use of cervical cerclage as a treatment option for cervical incompetence: patient characteristics, presentation and management over a 9 year period in a Kenyan centre. (24069746)
2013
3
Effects of maternal cervical incompetence on morbidity and mortality of very low birthweight neonates. (20234141)
2010
4
Pessary use for the treatment of cervical incompetence and prevention of preterm labour. (20334532)
2010
5
Ambispective study on Mac Donald suturing in pregnant ladies with cervical incompetence in Dhulikhel Hospital. (22610738)
2010
6
Management of cervical incompetence in Aba, south-eastern Nigeria. (16353700)
2005
7
A five century evolution of cervical incompetence as a clinical entity. (15777226)
2005
8
Preterm deliveries among women with MacDonald cerclage performed due to cervical incompetence. (15192297)
2004
9
Controversies regarding cervical incompetence, short cervix, and the need for cerclage. (15519424)
2004
10
Complications of cervical cerclage in women with cervical incompetence. (14643041)
2003
11
Diagnostic features of cervical incompetence among women in Maiduguri. (12745553)
2003
12
Cervical incompetence: a reappraisal of an obstetric controversy. (12140372)
2002
13
Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): effect of therapeutic cerclage with bed rest vs. bed rest only on cervical length. (12153667)
2002
14
Hematometra after thermal balloon endometrial ablation in a patient with cervical incompetence. (11642669)
2001
15
Cervical incompetence: elective, emergent, or urgent cerclage. (10454663)
1999
16
MRI appearance of cervical incompetence in a pregnant patient. (10576725)
1999
17
Emergency cervical cerclage for cervical incompetence. (15511978)
1997
18
Transabdominal cervico-isthmic cerclage in the management of cervical incompetence. (9134389)
1997
19
Transvaginal ultrasound in the management of women with suspected cervical incompetence. (9091022)
1997
20
Outcome of second-trimester, emergency cervical cerclage in patients with no history of cervical incompetence. (8960611)
1996
21
Cervical incompetence and cerclage in Denmark 1980-1990. A register based epidemiological survey. (8304022)
1994
22
Interval evaluation of the cervix for predicting pregnancy outcome and diagnosing cervical incompetence. (8320673)
1993
23
Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance. (1415396)
1992
24
Cervical incompetence. (2666173)
1989
25
Sonographic detection of cervical incompetence. (3282735)
1988
26
Cervical incompetence and preterm labor. (3224459)
1988
27
Transabdominal cerclage for fetal wastage due to cervical incompetence. (3285265)
1988
28
Cervical incompetence. A review. (3553584)
1987
29
Ultrasonic evaluation of cervical incompetence. (3513849)
1986
30
Successful use of transabdominal isthmic cerclage in the management of cervical incompetence. (3533673)
1986
31
Negative sonographic findings followed by rapid cervical dilatation due to cervical incompetence. (3885104)
1985
32
Negative sonographic findings followed by rapid cervical dilatation due to cervical incompetence. (6738939)
1984
33
Stress relaxation of the human cervix: a new tool for diagnosis of cervical incompetence. (6488727)
1984
34
Therapeutic abortion, premature labour and cervical incompetence. (6669117)
1983
35
The influence of progesterone treatment on the course and outcome of pregnancies following suture of the cervix for cervical incompetence. (7307264)
1981
36
Ultrasonography in the diagnosis of cervical incompetence in pregnancy-a new diagnostic approach. (7248221)
1981
37
Reproductive failure and cervical incompetence in women exposed to diethylstilbestrol. (7350691)
1980
38
Cervical incompetence. (567428)
1978
39
Cervical incompetence and premature delivery after bromocriptine therapy for infertility. (70705)
1977
40
Letter: prostaglandin-induced abortion and cervical incompetence. (1148669)
1975
41
Letter: Cervical incompetence. (4419859)
1974
42
Shirodkar suture for cervical incompetence. (4574407)
1973
43
Triplet pregnancy and cervical incompetence. A case report. (4644559)
1972
44
The problem of cervical incompetence in Malaysian women. (4268034)
1972
45
Cervical incompetence in multiple pregnancy. (5438149)
1970
46
Management of cervical incompetence. (5347310)
1969
47
Cervical incompetence: surgical treatment of twenty-four cases during pregnancy. (6079200)
1967
48
Cerclage for cervical incompetence. (5337684)
1967
49
Congenital cervical incompetence in primigravidas. (13973022)
1963
50
The Shirodkar procedure for cervical incompetence. (13917858)
1962

Genetic Variations for Cervical Incompetence

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Expression for genes affiliated with Cervical Incompetence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Incompetence

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Pathways for genes affiliated with Cervical Incompetence

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Cervical Incompetence

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GO Terms for genes affiliated with Cervical Incompetence

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16Gene Ontology
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Cellular components related to Cervical Incompetence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.3LEPRE1, CRTAP, TNXB
2collagen type VGO:0055888.9COL5A1, COL5A2
3extracellular matrixGO:0310128.3TNXB, COL5A2, COL5A1
4endoplasmic reticulum lumenGO:0057887.7SERPINH1, LEPRE1, CRTAP, COL5A2, COL5A1

Biological processes related to Cervical Incompetence according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cell growthGO:0160499.5IL6, LEPRE1
2extracellular fibril organizationGO:0432069.3TNXB, COL5A1
3collagen biosynthetic processGO:0329649.2COL5A1, SERPINH1
4eye morphogenesisGO:0485929.2COL5A2, COL5A1
5skin developmentGO:0435889.0COL5A2, COL5A1
6extracellular matrix disassemblyGO:0226179.0COL5A2, COL5A1
7collagen catabolic processGO:0305748.7COL5A2, COL5A1
8collagen fibril organizationGO:0301998.0SERPINH1, LEPRE1, TNXB, COL5A2, COL5A1
9extracellular matrix organizationGO:0301987.9COL5A1, COL5A2, CRTAP, LEPRE1, SERPINH1

Molecular functions related to Cervical Incompetence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen bindingGO:0055189.4SERPINH1, TNXB
2integrin bindingGO:0051789.2TNXB, COL5A1
3extracellular matrix structural constituentGO:0052018.7COL5A2, COL5A1

Products for genes affiliated with Cervical Incompetence

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Sources for Cervical Incompetence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet