MCID: CRV025
MIFTS: 36

Cervical Incompetence

Categories: Reproductive diseases

Aliases & Classifications for Cervical Incompetence

MalaCards integrated aliases for Cervical Incompetence:

Name: Cervical Incompetence 12 14
Uterine Cervical Incompetence 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9681
ICD10 33 N88.3
ICD9CM 35 622.5
MeSH 42 D002581
NCIt 47 C50607
UMLS 69 C0007871

Summaries for Cervical Incompetence

Disease Ontology : 12 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards based summary : Cervical Incompetence, also known as uterine cervical incompetence, is related to cervix disease and cervicitis. An important gene associated with Cervical Incompetence is IL6 (Interleukin 6), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Dinoprostone and Misoprostol have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and placenta, and related phenotypes are limbs/digits/tail and skeleton

Wikipedia : 72 N88.3... more...

Related Diseases for Cervical Incompetence

Graphical network of the top 20 diseases related to Cervical Incompetence:



Diseases related to Cervical Incompetence

Symptoms & Phenotypes for Cervical Incompetence

MGI Mouse Phenotypes related to Cervical Incompetence:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.26 HOXA11 P3H1 PLOD1 SERPINH1
2 skeleton MP:0005390 9.17 COL5A2 CRTAP HOXA11 IL6 P3H1 PLOD1

Drugs & Therapeutics for Cervical Incompetence

Drugs for Cervical Incompetence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Phase 4 363-24-6 5280360
2
Misoprostol Approved Phase 4,Phase 3 59122-46-2 5282381
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Chloroprocaine Approved Phase 4 133-16-4 8612
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
7 Antacids Phase 4,Phase 3
8 Anti-Ulcer Agents Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 Oxytocics Phase 4,Phase 3
11 Analgesics Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Anesthetics Phase 4
14 Adjuvants, Anesthesia Phase 4
15 Analgesics, Opioid Phase 4
16 Anesthetics, General Phase 4
17 Anesthetics, Intravenous Phase 4
18 Anesthetics, Local Phase 4
19 Central Nervous System Depressants Phase 4
20 Narcotics Phase 4
21 Pharmaceutical Solutions Phase 4
22
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
23
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
24
Silicon Investigational Phase 3 7440-21-3 4082203
25 Contraceptive Agents Phase 3
26 Contraceptives, Oral Phase 3
27 Contraceptives, Postcoital Phase 3
28 Hormone Antagonists Phase 3,Phase 2
29 Hormones Phase 3,Phase 2
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
31 Luteolytic Agents Phase 3
32 Progestins Phase 2, Phase 3
33
Menthol Approved 2216-51-5 16666
34
Cefazolin Approved 25953-19-9 656510 33255
35
Clindamycin Approved, Vet_approved 18323-44-9 29029
36
Indomethacin Approved, Investigational 53-86-1 3715
37
Acetylcysteine Approved, Investigational 616-91-1 12035
38
Lidocaine Approved, Vet_approved 137-58-6 3676
39 Analgesics, Non-Narcotic
40 Anti-Bacterial Agents
41 Antibiotics, Antitubercular
42 Anti-Infective Agents
43 Anti-Inflammatory Agents
44 Anti-Inflammatory Agents, Non-Steroidal
45 Antirheumatic Agents
46 Antitubercular Agents
47 Clindamycin palmitate
48 Clindamycin phosphate
49 Cyclooxygenase Inhibitors
50 Tocolytic Agents

Interventional clinical trials:

(show all 23)

id Name Status NCT ID Phase Drugs
1 Intravaginal Misoprostol Versus Dinoprostone Before Diagnostik Hysteroscopy Unknown status NCT01620814 Phase 4 Dinoprostone;misoprostol;control
2 Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Not yet recruiting NCT03305575 Phase 4 Chloroprocaine;Bupivacaine
3 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Not yet recruiting NCT02862912 Phase 4 Chloroprocaine;Bupivacaine;Fentanyl;Saline
4 Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination Unknown status NCT01795599 Phase 3 Mifegyne ®;Gymiso®
5 Physical Examination-Indicated Pessary Recruiting NCT02967445 Phase 3
6 Cerclage for Twins With Short Cervix Not yet recruiting NCT03077633 Phase 2, Phase 3 Vaginal Progesterone
7 The Effect of Adjunctive Use of Vaginal Progesterone After Cerclage on Prevention of 2nd Trimester Miscarriage Recruiting NCT02846909 Phase 2 Progesterone
8 Patient Attitudes Toward Ultrasound Measurement of Cervical Length Unknown status NCT01482039
9 Preventing Preterm Birth With a Pessary Unknown status NCT01380158
10 Multifactorial Approach to Emergent Cerclage Completed NCT01114516 Indomethacin and antibiotics (cefazolin or clindamycin)
11 Dilapan-S Osmotic Dilator in Pre-induction of Labor Completed NCT02098382
12 N-Acetyl Cysteine After Cervical Cerclage Completed NCT00787813 N-Acetyl Cysteine;Placebo
13 The Biomarker Study Completed NCT01148654
14 Amniotic Fluid Sludge in Cerclage Patients as an Indicator for Increased Risk of Preterm Delivery and Neonatal Outcome. Completed NCT00722085
15 Cerclage vs Cervical Pessary in Women With Cervical Incompetence Recruiting NCT02405455
16 Use of Pessary in Case of Cervical Insufficiency and Short Cervix Recruiting NCT03096691
17 Prolene Versus Ethibond for Cervical Cerclage Recruiting NCT03311867
18 CellulaR Injury and Preterm Birth Recruiting NCT02441335
19 Prevention of Preterm Birth in Singletons Using Pessary After Resolutive Threatened Preterm Labor Recruiting NCT02484820
20 The Impact of Cervical Cerclage or Vaginal Progesterone on Vaginal Microbiome Distribution Recruiting NCT03253016
21 Maternal Gut Microbiome (MGM) Study of Diet, the Gut Microbiome and Preterm Birth Recruiting NCT02560246
22 Cervical Occlusion for the Prevention of Preterm Birth Terminated NCT01737788
23 Determination of ED90 of Intrathecal Lidocaine for Adequate Anesthesia for Elective Cervical Cerclage Surgery Terminated NCT02574832 Lidocaine Administration

Search NIH Clinical Center for Cervical Incompetence

Cochrane evidence based reviews: uterine cervical incompetence

Genetic Tests for Cervical Incompetence

Anatomical Context for Cervical Incompetence

MalaCards organs/tissues related to Cervical Incompetence:

39
Cervix, Testes, Placenta

Publications for Cervical Incompetence

Articles related to Cervical Incompetence:

(show top 50) (show all 158)
id Title Authors Year
1
Co-morbidity of cervical incompetence with polycystic ovarian syndrome (PCOS) negatively impacts prognosis: A retrospective analysis of 178 patients. ( 27733131 )
2016
2
EP18.11: Prenatal diagnosis of caput succedaneum associated with cervical incompetence at 16 weeks. ( 27647484 )
2016
3
Role of Cervical Cerclage and Vaginal Progesterone in the Treatment of Cervical Incompetence with/without Preterm Birth History. ( 27823998 )
2016
4
Successful delivery after transabdominal cerclage of uterine cervix for cervical incompetence after radical trachelectomy. ( 25944172 )
2015
5
Laparoscopic Cerclage for Prevention of Recurrent Pregnancy Loss Due to Cervical Incompetence. ( 27679035 )
2015
6
Successful treatment of cervical incompetence using a modified laparoscopic cervical cerclage technique: a cohort study. ( 24965992 )
2014
7
Effects of Maternal Cervical Incompetence on Morbidity and Mortality of Preterm Neonates with Birth weight Less than 2000g. ( 26019783 )
2014
8
Use of cervical cerclage as a treatment option for cervical incompetence: patient characteristics, presentation and management over a 9 year period in a Kenyan centre. ( 24069746 )
2013
9
Oxidative status shifts in uterine cervical incompetence patients. ( 24304328 )
2013
10
Cervical funneling after cerclage in cervical incompetence as a predictor of pregnancy outcome. ( 21463213 )
2012
11
Pregnancy outcome after cerclage for cervical incompetence at the University of Port Harcourt Teaching Hospital, Port Harcourt. ( 23437511 )
2012
12
Cervical incompetence associated with congenital uterine malformations. ( 23700889 )
2012
13
Effective treatment of cervical incompetence in a monochorionic monoamniotic twin pregnancy with a rescue cervical cerclage and pessary--a case report and review of literature. ( 23488300 )
2012
14
Laparoscopic cervicoisthmic cerclage for the treatment of cervical incompetence: case reports. ( 22519240 )
2011
15
Effects of maternal cervical incompetence on morbidity and mortality of very low birthweight neonates. ( 20234141 )
2010
16
Pessary use for the treatment of cervical incompetence and prevention of preterm labour. ( 20334532 )
2010
17
Association of very high Hungarian rate of preterm births with cervical incompetence in pregnant women. ( 20586224 )
2010
18
Ambispective study on Mac Donald suturing in pregnant ladies with cervical incompetence in Dhulikhel Hospital. ( 22610738 )
2010
19
Uterine Didelphys with Pregnancy and Cervical Incompetence. ( 27407898 )
2006
20
Noninvasive cerclage for the management of cervical incompetence: a prospective study. ( 16222537 )
2006
21
Management of cervical incompetence in Aba, south-eastern Nigeria. ( 16353700 )
2005
22
Laparoscopic cervico-uterine cerclage using polypropylene mesh for the treatment of cervical incompetence. ( 16026416 )
2005
23
A five century evolution of cervical incompetence as a clinical entity. ( 15777226 )
2005
24
Cervical incompetence and the role of emergency cerclage. ( 15937588 )
2005
25
Controversies regarding cervical incompetence, short cervix, and the need for cerclage. ( 15519424 )
2004
26
Preterm deliveries among women with MacDonald cerclage performed due to cervical incompetence. ( 15192297 )
2004
27
Interleukin-6, but not relaxin, predicts outcome of rescue cerclage in women with cervical incompetence. ( 15467541 )
2004
28
Cervical surveillance as an alternative to elective cervical cerclage for pregnancy management of suspected cervical incompetence. ( 15191447 )
2004
29
Vaginal sonography and cervical incompetence. ( 12592276 )
2003
30
Elective and emergency transabdominal cervicoisthmic cerclage for cervical incompetence. ( 12971139 )
2003
31
Cervical incompetence prevention randomized cerclage trial: emergency cerclage with bed rest versus bed rest alone. ( 14586323 )
2003
32
Diagnostic features of cervical incompetence among women in Maiduguri. ( 12745553 )
2003
33
Complications of cervical cerclage in women with cervical incompetence. ( 14643041 )
2003
34
Cervical incompetence: a reappraisal of an obstetric controversy. ( 12140372 )
2002
35
Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): effect of therapeutic cerclage with bed rest vs. bed rest only on cervical length. ( 12153667 )
2002
36
Hematometra after thermal balloon endometrial ablation in a patient with cervical incompetence. ( 11642669 )
2001
37
Cervical incompetence: the use of transvaginal sonography to provide an objective diagnosis. ( 11555448 )
2001
38
The value of transvaginal ultrasonography in diagnosis and management of cervical incompetence. ( 11838756 )
2001
39
Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone. ( 11717642 )
2001
40
Cervical incompetence: the use of selective and emergency cerclage. ( 11234614 )
2001
41
Cervical incompetence prevention randomized cerclage trial (CIPRACT): study design and preliminary results. ( 11035320 )
2000
42
The epidemiology of cervical incompetence in Ramathibodi Hospital between 1982-1997. ( 10511780 )
1999
43
MRI appearance of cervical incompetence in a pregnant patient. ( 10576725 )
1999
44
Cervical incompetence: elective, emergent, or urgent cerclage. ( 10454663 )
1999
45
Can examination of the cervix provide useful information for prediction of cervical incompetence and following preterm labour? ( 10554937 )
1999
46
Diagnostic imaging in cervical incompetence. ( 10191659 )
1998
47
Transvaginal ultrasound in the management of women with suspected cervical incompetence. ( 9091022 )
1997
48
Transvaginal ultrasound in the management of women with suspected cervical incompetence. ( 9091023 )
1997
49
The natural history of a positive response to transfundal pressure in women at risk for cervical incompetence. ( 9077619 )
1997
50
Transabdominal cervico-isthmic cerclage in the management of cervical incompetence. ( 9134389 )
1997

Variations for Cervical Incompetence

Expression for Cervical Incompetence

Search GEO for disease gene expression data for Cervical Incompetence.

Pathways for Cervical Incompetence

GO Terms for Cervical Incompetence

Cellular components related to Cervical Incompetence according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.62 CRTAP P3H1 PLOD1 SERPINH1
2 proteinaceous extracellular matrix GO:0005578 9.33 COL5A2 CRTAP P3H1
3 collagen trimer GO:0005581 9.26 COL5A2 SERPINH1
4 endoplasmic reticulum lumen GO:0005788 9.02 COL5A2 CRTAP IL6 P3H1 SERPINH1
5 macromolecular complex GO:0032991 8.96 CRTAP P3H1

Biological processes related to Cervical Incompetence according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chaperone-mediated protein folding GO:0061077 9.16 CRTAP P3H1
2 bone development GO:0060348 8.96 P3H1
3 collagen fibril organization GO:0030199 8.96 COL5A2 SERPINH1
4 negative regulation of post-translational protein modification GO:1901874 8.62 CRTAP P3H1

Molecular functions related to Cervical Incompetence according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dioxygenase activity GO:0051213 9.26 P3H1 PLOD1
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.16 P3H1 PLOD1
3 collagen binding GO:0005518 8.96 P3H1 SERPINH1
4 L-ascorbic acid binding GO:0031418 8.62 P3H1 PLOD1

Sources for Cervical Incompetence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....