CIN
MCID: CRV045
MIFTS: 47

Cervical Intraepithelial Neoplasia (CIN) malady

Summaries for Cervical Intraepithelial Neoplasia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia and cervical interstitial... more...

MalaCards: Cervical Intraepithelial Neoplasia, also known as CIN, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Cervical Intraepithelial Neoplasia is TERC (telomerase RNA component), and among its related pathways are DNA Damage and E2F transcription factor network. The compounds retinoic acid and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include cervix, monocytes and t cells, and related mouse phenotypes are mortality/aging and tumorigenesis.

Aliases & Classifications for Cervical Intraepithelial Neoplasia

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS, 39NCBI Bookshelf
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Aliases & Descriptions:

cervical intraepithelial neoplasia 43 45 61
cin 39


Related Diseases for Cervical Intraepithelial Neoplasia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cervical Intraepithelial Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.3TP73, NME1, MKI67, ODC1
2adenocarcinoma31.0TP73, TERC, TERT, KRT17, KRT8, KRT10
3colorectal cancer29.9TP73, TERC, TERT, KRT8, CFLAR, NME1
4adenocarcinoma in situ10.6
5squamous cell papilloma10.5
6trachoma10.5
7vulvar intraepithelial neoplasia10.5
8bacterial vaginosis10.5
9anal squamous cell carcinoma10.4
10vaginal cancer10.4
11cervix uteri carcinoma in situ10.2
12ovarian squamous cell carcinoma10.2
13n syndrome10.2
14epidermodysplasia verruciformis10.2
15uterine disease10.2
16vaginitis10.2
17vulva cancer10.2
18vulva squamous cell carcinoma10.2
19vulvar squamous papilloma10.2
20bowenoid papulosis10.2
21drug addiction10.2
22invasive mole10.2
23breast cancer10.0TP73, YY1, TERC, TERT, KRT8, CFLAR
24hepatocellular carcinoma10.0TP73, TERC, TERT, KRT8, CFLAR, NME1
25prostate cancer10.0TP73, YY1, TERC, TERT, KRT8, CFLAR
26melanoma10.0TP73, TERC, TERT, KRT8, CFLAR, NME1
27leukemia10.0TP73, YY1, TERC, TERT, KRT10, CFLAR
28cervical cancer10.0TERC, TERT, KRT8, KRT10, CFLAR, NME1
29retinoblastoma10.0TP73, YY1, TERC, TERT, KRT10, NME1
30stomach cancer10.0TP73, TERC, TERT, CFLAR, NME1, CDKN2A
31adenoma10.0TP73, TERC, TERT, KRT8, NME1, CDKN2A
32pancreatic cancer10.0YY1, TERC, TERT, KRT8, CFLAR, CDKN2A
33osteosarcoma10.0TP73, YY1, TERT, CFLAR, NME1, CDKN2A
34papilloma10.0TP73, KRT10, CDKN2A, IVL, RBL1, IFI27
35leukoplakia10.0TERC, KRT8, NME1, MKI67, IVL, IFI27
36oral cancer10.0TP73, TERC, TERT, CDKN2A, VEGFC, IVL
37laryngeal squamous cell carcinoma10.0TP73, TERT, NME1, CDKN2A, MKI67, VEGFC
38keratoacanthoma10.0KRT17, KRT10, NME1, MKI67, IVL, GZMB
39basal cell carcinoma10.0KRT17, KRT8, KRT10, MKI67, IVL, GZMB
40bladder carcinoma10.0TERT, KRT8, KRT10, CDKN2A, MKI67, IFI27
41sarcoma10.0TERT, KRT8, CFLAR, MKI67, CCNG1, ODC1
42transitional cell carcinoma10.0TERC, KRT8, NME1, MKI67, VEGFC, IFI27
43cervical squamous cell carcinoma10.0TP73, KRT8, KRT10, CDKN2A, MKI67, IVL
44kidney cancer10.0TP73, KRT8, CFLAR, NME1, MKI67, VEGFC
45gastric adenocarcinoma10.0TERC, KRT8, CFLAR, NME1, VEGFC, ODC1
46colon cancer10.0TP73, TERT, KRT8, CFLAR, NME1, GZMB
47non-small cell lung carcinoma10.0TP73, TERT, NME1, CDKN2A, VEGFC, IFI27
48psoriasis10.0KRT17, KRT10, IVL, GZMB, ODC1
49b-cell lymphomas10.0CFLAR, CDKN2A, MKI67, RBL1, GZMB, IFI27
50gallbladder cancer10.0TERT, KRT8, NME1, MKI67, IFI27

Graphical network of the top 20 diseases related to Cervical Intraepithelial Neoplasia:



Diseases related to cervical intraepithelial neoplasia

Clinical Features for Cervical Intraepithelial Neoplasia

Drugs & Therapeutics for Cervical Intraepithelial Neoplasia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Intraepithelial Neoplasia

Drug clinical trials:

Search ClinicalTrials for Cervical Intraepithelial Neoplasia

Search NIH Clinical Center for Cervical Intraepithelial Neoplasia

Search CenterWatch for Cervical Intraepithelial Neoplasia

Genetic Tests for Cervical Intraepithelial Neoplasia

Anatomical Context for Cervical Intraepithelial Neoplasia

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33MalaCards
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MalaCards organs/tissues related to Cervical Intraepithelial Neoplasia:

33
Cervix, Monocytes, T cells, B cells, Endothelial, Appendix

Animal Models for Cervical Intraepithelial Neoplasia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Cervical Intraepithelial Neoplasia

Sources:
51PubMed
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Articles related to Cervical Intraepithelial Neoplasia:

(show top 50)    (show all 644)
idTitleAuthorsYear
1
Authors' reply: Impact of loop electrosurgical excision procedure for cervical intraepithelial neoplasia on HIV-1 genital shedding: a prospective cohort study: population and statistical queries. (24428454)
2014
2
Meta-analysis of the effectiveness of cryotherapy in the treatment of cervical intraepithelial neoplasia. (23265830)
2013
3
High-risk human papilloma virus management in pregnancy with cervical intraepithelial neoplasia during pregnancy and postpartum in China. (24125014)
2013
4
Adenocarcinoma arising from vaginal stump: unusual vaginal carcinogenesis 7 years after hysterectomy due to cervical intraepithelial neoplasia. (24071878)
2013
5
Umbilication is a strong predictor of high-grade cervical intraepithelial neoplasia. (23486068)
2013
6
Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intraepithelial neoplasia II/III and cervical cancer: a meta-analysis. (23864153)
2013
7
Clinical progression of high-grade cervical intraepithelial neoplasia: estimating the time to preclinical cervical cancer from doubly censored national registry data. (23897645)
2013
8
Plasma-free amino acid profiling of cervical cancer and cervical intraepithelial neoplasia patients and its application for early detection. (24068431)
2013
9
Prediction, based on resection margins, of long-term outcome of cervical intraepithelial neoplasia 3 treated by Shimodaira-Taniguchi conization. (22109382)
2012
10
Different amplification patterns of the human telomerase RNA gene in invasive cervical carcinomas and cervical intraepithelial neoplasia grade III. (21381227)
2012
11
Value-based medicine analysis on loop electrosurgical excision procedure and CO2 laser vaporization for the treatment of cervical intraepithelial neoplasia 2. (22568858)
2012
12
Interaction of epithelial biomarkers, local immune response and condom use in cervical intraepithelial neoplasia 2-3 regression. (23017821)
2012
13
Role of high-risk human papillomavirus (HPV) mRNA testing in the prediction of residual disease after conisation for high-grade cervical intraepithelial neoplasia. (21839500)
2011
14
Vaginal delivery and low immunity are strongly associated with high-grade cervical intraepithelial neoplasia in a high-risk population. (21436727)
2011
15
Re: Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection. (21115883)
2011
16
Risk factors for persistent cervical intraepithelial neoplasia grades 1 and 2: managed by watchful waiting. (21811178)
2011
17
Biomarker expression in cervical intraepithelial neoplasia: potential progression predictive factors for low-grade lesions. (21315414)
2011
18
A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia. (21463750)
2011
19
Obstetric outcomes after treatment for cervical intraepithelial neoplasia: six years of experience. (21959571)
2011
20
Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. (21052817)
2011
21
Cervical HIV-1 RNA shedding after cryotherapy among HIV-positive women with cervical intraepithelial neoplasia stage 2 or 3. (21716072)
2011
22
Usefulness of serum mass spectrometry to identify women diagnosed with higher grades of cervical intraepithelial neoplasia may differ by race. (21792340)
2011
23
Re: Consequences in women of participating in a study of the natural history of cervical intraepithelial neoplasia 3. (21466527)
2011
24
Prospective study of the association of serum gamma-glutamyltransferase with cervical intraepithelial neoplasia III and invasive cervical cancer. (20388786)
2010
25
Use of various contraceptives and human papillomavirus 16 and 18 infections in women with cervical intraepithelial neoplasia. (20606223)
2010
26
The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia. (19777358)
2010
27
Ki-67 quantitative evaluation as a marker of cervical intraepithelial neoplasia and human papillomavirus infection. (20130511)
2010
28
Recurrent rates with cervical intraepithelial neoplasia having a negative surgical margin after the loop electrosurgical excision procedure in Thailand. (19827874)
2009
29
Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status. (19407553)
2009
30
Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out. (20169277)
2009
31
Postpartum outcome of cervical intraepithelial neoplasia in pregnant women determined by route of delivery. (19564643)
2009
32
HPV in situ hybridization signal patterns as a marker for cervical intraepithelial neoplasia progression. (19007972)
2009
33
Value of p16(INK4a) as a marker of progression/regression in cervical intraepithelial neoplasia grade 1. (19683687)
2009
34
Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women. (19293802)
2009
35
Cervical intraepithelial neoplasia and aneusomy of TERC: assessment of liquid-based cytological preparations. (19191295)
2009
36
Epidemiological characteristics related to treatment failure of preinvasive cervical intraepithelial neoplasia among Brazilian women. (20009902)
2009
37
Pregnancy outcome after treatment for cervical intraepithelial neoplasia. (19888028)
2009
38
Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. (18482945)
2008
39
Role of cervicitis in the Raman-based optical diagnosis of cervical intraepithelial neoplasia. (19021409)
2008
40
Risks for cervical intraepithelial neoplasia 3 among adolescents and young women with abnormal cytology. (19037044)
2008
41
Natural history of cervical intraepithelial neoplasia during pregnancy. (18951206)
2008
42
Estimation of prognoses for cervical intraepithelial neoplasia 2 by p16INK4a immunoexpression and high-risk HPV in situ hybridization signal types. (17638654)
2007
43
p14ARF and p16INK4A, two products of the same gene, are differently expressed in cervical intraepithelial neoplasia. (16406113)
2006
44
Misdiagnosis of high-grade vulvar intraepithelial neoplasia (VIN III) as mild cervical intraepithelial neoplasia (CIN I) on Papanicolaou tests. (12521370)
2003
45
Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia. (10928104)
2000
46
Angiogenesis in histologically benign squamous mucosa is a sensitive marker for nearby cervical intraepithelial neoplasia. (14517469)
1998
47
p53 and human papilloma virus type 16 in cervical intraepithelial neoplasia and carcinoma. (8601524)
1995
48
Polyamines as biomarkers of cervical intraepithelial neoplasia. (8747382)
1995
49
Detection of a small molecular species of human chorionic gonadotropin in the urine of patients with carcinoma of the cervix and cervical intraepithelial neoplasia: comparison with other assays for human chorionic gonadotropin and its fragments. (2344970)
1990
50
Human papillomavirus DNA in adenocarcinoma in situ, microinvasive adenocarcinoma of the uterine cervix, and coexisting cervical squamous intraepithelial neoplasia. (2540102)
1989

Genetic Variations for Cervical Intraepithelial Neoplasia

Expression for genes affiliated with Cervical Intraepithelial Neoplasia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Intraepithelial Neoplasia

Search GEO for disease gene expression data for Cervical Intraepithelial Neoplasia.

Pathways for genes affiliated with Cervical Intraepithelial Neoplasia

Sources:
4Cell Signaling Technology, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6MKI67, CDKN2A, CDC6, YY1, TP73
210.6TP73, RBL1, CDC6, YY1
3
Hide members
10.6CFLAR, CDKN2A, GZMB
410.6TERT, ODC1, NME1
510.6TP73, CCNG1, CDKN2A

Compounds for genes affiliated with Cervical Intraepithelial Neoplasia

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
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Compounds related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2412.4IVL, VEGFC, MKI67, CDKN2A, NME1, CFLAR
2oligonucleotide4511.4IFI27, GZMB, RBL1, IVL, VEGFC, CDKN2A
3paraffin4511.3VEGFC, MKI67, CDKN2A, NME1, KRT10, KRT8
4calcium45 50 11 2414.3VEGFC, IVL, RBL1, GZMB, IFI27, CCNG1
5tyrosine4511.3VEGFC, IVL, GZMB, IFI27, CCNG1, ODC1
6cisplatin45 50 60 1114.3CCNG1, IFI27, GZMB, MKI67, CDKN2A, NME1
7thymidine45 2412.2ODC1, IFI27, RBL1, IVL, VEGFC, MKI67
8vegf4511.2IFI27, GZMB, IVL, VEGFC, MKI67, CDKN2A
9doxorubicin45 50 1113.2MKI67, IFI27, CCNG1, ODC1, CDKN2A, CFLAR
10lipid4511.2IFI27, GZMB, IVL, VEGFC, MKI67, CDKN2A
115fluorouracil4511.2RBL1, IVL, MKI67, CDKN2A, NME1, CFLAR
12progesterone45 60 29 11 2415.2IFI27, VEGFC, MKI67, CDKN2A, NME1, KRT10
13steroid4511.2CCNG1, IFI27, GZMB, MKI67, CDKN2A, NME1
14serine4511.2CCNG1, GZMB, RBL1, IVL, MKI67, NME1
15testosterone45 60 11 2414.1ODC1, CCNG1, IFI27, VEGFC, MKI67, CDKN2A
16nitric oxide45 11 2413.1ODC1, GZMB, VEGFC, MKI67, CDKN2A, NME1
17adriamycin4511.1ODC1, CDKN2A, CFLAR, KRT8, TERT, TERC
18arginine4511.1ODC1, IFI27, GZMB, RBL1, MKI67, CDKN2A
19threonine4511.1CCNG1, IFI27, MKI67, CDKN2A, CFLAR, KRT10
20retinoid4511.1ODC1, CCNG1, IFI27, IVL, KRT10, KRT8
21dexamethasone45 50 29 1114.1CCNG1, IFI27, GZMB, VEGFC, CDKN2A, NME1
22glucose4511.1CCNG1, GZMB, IVL, VEGFC, CDKN2A, CFLAR
23paclitaxel45 50 1113.0ODC1, IFI27, CDKN2A, CFLAR, KRT8, TERT
24bromodeoxyuridine4511.0ODC1, IFI27, IVL, MKI67, KRT10, KRT8
25etoposide45 50 60 1114.0GZMB, CDC6, CFLAR, KRT8, TERT
26lactate4511.0ODC1, IFI27, GZMB, IVL, MKI67, NME1
27atp45 2912.0GZMB, RBL1, CDKN2A, CDC6, NME1, KRT8
28fatty acid4511.0IFI27, IVL, CDKN2A, NME1, KRT10, TP73
29oxygen45 2412.0IFI27, GZMB, IVL, VEGFC, MKI67, CDKN2A
30cysteine4511.0ODC1, GZMB, IVL, CDKN2A, NME1, CFLAR
31hematoxylin4511.0IVL, MKI67, CDKN2A, KRT10, KRT8
32rapamycin4511.0ODC1, CCNG1, IFI27, GZMB, CFLAR, TERT
33actinomycin d4511.0ODC1, CCNG1, CDKN2A, CFLAR, KRT8, TP73
34thymidylate4510.9TERT, CDKN2A, MKI67, IFI27, ODC1
35estrogen4510.9IVL
36p0024510.9IFI27, MKI67, NME1, CFLAR, TP73
37vincristine45 50 1112.9ODC1, MKI67, CFLAR, TP73
38butyrate4510.9YY1
39calcitriol45 60 11 2413.9IFI27, IVL, NME1, KRT10, TERT
40chloramphenicol45 2 1112.8ODC1, IVL, CDKN2A, YY1, TP73
41agar4510.8ODC1, CDKN2A, NME1, KRT8, TERC
42hpvs4510.8RBL1, CDKN2A, YY1
43chi 24510.7IFI27, MKI67, NME1
44acitretin45 1111.7ODC1, IVL, KRT17
45adpribose4510.7YY1, TERC, TERT, IFI27
46ribonucleic acid4510.7ODC1, GZMB, VEGFC, NME1, TERT
47camptothecin45 60 1112.6TP73, TERT, CFLAR, CDKN2A
48isotretinoin45 1111.6KRT10, MKI67, ODC1
49p000014510.5VEGFC, MKI67, CDKN2A
50gold4510.2KRT8, IVL

GO Terms for genes affiliated with Cervical Intraepithelial Neoplasia

Sources:
16Gene Ontology
See all sources

Cellular components related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.6KRT17, KRT8, KRT10
2cytoplasmGO:00573710.5SPRR1B, GZMB, IVL, MKI67, CDKN2A, CDC6

Biological processes related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratinizationGO:03142410.6SPRR1B, KRT17, IVL
2response to organonitrogen compoundGO:01024310.5TP73, CCNG1
3keratinocyte differentiationGO:03021610.5IVL, KRT10, SPRR1B
4replicative senescenceGO:09039910.2TERT, CDKN2A

Molecular functions related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9TP73, GZMB, RBL1, VEGFC, MKI67, CDKN2A

Products for genes affiliated with Cervical Intraepithelial Neoplasia

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Sources for Cervical Intraepithelial Neoplasia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet