CIN
MCID: CRV045
MIFTS: 36

Cervical Intraepithelial Neoplasia (CIN) malady

Summaries for Cervical Intraepithelial Neoplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia and cervical interstitial... more...

MalaCards: Cervical Intraepithelial Neoplasia, also known as CIN, is related to cervical cancer and cervical squamous cell carcinoma. An important gene associated with Cervical Intraepithelial Neoplasia is TERC (telomerase RNA component), and among its related pathways are DNA Damage and E2F transcription factor network. The compounds retinoic acid and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include cervix, and related mouse phenotypes are mortality/aging and tumorigenesis.

Aliases & Classifications for Cervical Intraepithelial Neoplasia

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42NIH Rare Diseases, 44Novoseek, 60UMLS, 38NCBI Bookshelf
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Aliases & Descriptions:

cervical intraepithelial neoplasia 42 44 60
cin 38


Related Diseases for Cervical Intraepithelial Neoplasia

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17GeneCards, 18GeneDecks
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Diseases related to Cervical Intraepithelial Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1cervical cancer31.7TERC, TERT, KRT8, KRT10, CFLAR, NME1
2cervical squamous cell carcinoma31.3TP73, KRT8, KRT10, CDKN2A, MKI67, IVL
3squamous cell carcinoma31.3TP73, NME1, MKI67, ODC1
4papilloma31.0TP73, KRT10, CDKN2A, IVL, RBL1, IFI27
5adenocarcinoma30.9TP73, TERC, TERT, KRT17, KRT8, KRT10
6cervical adenocarcinoma30.9KRT8, NME1, CDKN2A, IFI27
7retinoblastoma30.6TP73, YY1, TERC, TERT, KRT10, NME1
8colorectal cancer29.9TP73, TERC, TERT, KRT8, CFLAR, NME1
9cervicitis11.6
10vaginitis10.6
11endocervicitis10.6
12adenocarcinoma in situ10.6
13bacterial vaginosis10.4
14cell type cancer10.4
15conjunctivitis10.4
16in situ carcinoma10.4
17vaginal cancer10.4
18squamous cell papilloma10.2
19cervix uteri carcinoma in situ10.2
20ovarian squamous cell carcinoma10.2
21epidermodysplasia verruciformis10.2
22obesity10.2
23ovarian cyst10.2
24papillary adenocarcinoma10.2
25peritonitis10.2
26uterine disease10.2
27vulvar squamous papilloma10.2
28breast cancer10.0TP73, YY1, TERC, TERT, KRT8, CFLAR
29hepatocellular carcinoma10.0TP73, TERC, TERT, KRT8, CFLAR, NME1
30prostate cancer10.0TP73, YY1, TERC, TERT, KRT8, CFLAR
31melanoma10.0TP73, TERC, TERT, KRT8, CFLAR, NME1
32leukemia10.0TP73, YY1, TERC, TERT, KRT10, CFLAR
33stomach cancer10.0TP73, TERC, TERT, CFLAR, NME1, CDKN2A
34adenoma10.0TP73, TERC, TERT, KRT8, NME1, CDKN2A
35pancreatic cancer10.0YY1, TERC, TERT, KRT8, CFLAR, CDKN2A
36osteosarcoma10.0TP73, YY1, TERT, CFLAR, NME1, CDKN2A
37leukoplakia10.0TERC, KRT8, NME1, MKI67, IVL, IFI27
38oral cancer10.0TP73, TERC, TERT, CDKN2A, VEGFC, IVL
39laryngeal squamous cell carcinoma10.0TP73, TERT, NME1, CDKN2A, MKI67, VEGFC
40keratoacanthoma10.0KRT17, KRT10, NME1, MKI67, IVL, GZMB
41basal cell carcinoma10.0KRT17, KRT8, KRT10, MKI67, IVL, GZMB
42bladder carcinoma10.0TERT, KRT8, KRT10, CDKN2A, MKI67, IFI27
43sarcoma10.0TERT, KRT8, CFLAR, MKI67, CCNG1, ODC1
44transitional cell carcinoma10.0TERC, KRT8, NME1, MKI67, VEGFC, IFI27
45gastric adenocarcinoma10.0TERC, KRT8, CFLAR, NME1, VEGFC, ODC1
46kidney cancer10.0TP73, KRT8, CFLAR, NME1, MKI67, VEGFC
47colon cancer10.0TP73, TERT, KRT8, CFLAR, NME1, GZMB
48non-small cell lung carcinoma10.0TP73, TERT, NME1, CDKN2A, VEGFC, IFI27
49psoriasis10.0KRT17, KRT10, IVL, GZMB, ODC1
50b-cell lymphomas10.0CFLAR, CDKN2A, MKI67, RBL1, GZMB, IFI27

Graphical network of the top 20 diseases related to Cervical Intraepithelial Neoplasia:



Diseases related to cervical intraepithelial neoplasia

Clinical Features for Cervical Intraepithelial Neoplasia

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Drugs & Therapeutics for Cervical Intraepithelial Neoplasia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Intraepithelial Neoplasia

Drug clinical trials:

Search ClinicalTrials for Cervical Intraepithelial Neoplasia

Search NIH Clinical Center for Cervical Intraepithelial Neoplasia

Search CenterWatch for Cervical Intraepithelial Neoplasia

Genetic Tests for Cervical Intraepithelial Neoplasia

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Anatomical Context for Cervical Intraepithelial Neoplasia

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32MalaCards
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MalaCards organs/tissues related to Cervical Intraepithelial Neoplasia:

32
Cervix

Animal Models for Cervical Intraepithelial Neoplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cervical Intraepithelial Neoplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.2TP73, ODC1, CCNG1, GZMB, RBL1, VEGFC
2MP:000200611.0CCNG1, GZMB, RBL1, CDKN2A, NME1, KRT10
3MP:000538410.9ODC1, CCNG1, GZMB, RBL1, CDKN2A, CFLAR
4MP:000538110.9CCNG1, RBL1, CDKN2A, KRT8, KRT17, TERT
5MP:000538710.8CDKN2A, VEGFC, RBL1, GZMB, CFLAR, KRT10
6MP:000538010.8ODC1, RBL1, KRT8, YY1
7MP:000539710.8GZMB, RBL1, CDKN2A, NME1, CFLAR, KRT8
8MP:000537810.7RBL1, CDKN2A, NME1, CFLAR, KRT10, KRT8
9MP:001077110.6TERC, KRT17, NME1, CDKN2A, RBL1
10MP:000537610.3RBL1, TERC, YY1

Publications for Cervical Intraepithelial Neoplasia

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Genetic Variations for Cervical Intraepithelial Neoplasia

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Expression for genes affiliated with Cervical Intraepithelial Neoplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Intraepithelial Neoplasia

Search GEO for disease gene expression data for Cervical Intraepithelial Neoplasia.

Pathways for genes affiliated with Cervical Intraepithelial Neoplasia

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4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6MKI67, CDKN2A, CDC6, YY1, TP73
210.6TP73, YY1, CDC6, RBL1
3
Hide members
10.6CFLAR, CDKN2A, GZMB
410.6ODC1, NME1, TERT
510.6TP73, CDKN2A, CCNG1

Compounds for genes affiliated with Cervical Intraepithelial Neoplasia

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.4ODC1, TERC, TERT, KRT8, KRT10, CFLAR
2oligonucleotide4411.4CDKN2A, CDC6, NME1, CFLAR, KRT8, TERT
3paraffin4411.4TERC, KRT10, TERT, KRT17, KRT8, NME1
4calcium44 49 11 2414.3NME1, IFI27, CCNG1, GZMB, RBL1, IVL
5tyrosine4411.3IFI27, CCNG1, CFLAR, KRT8, GZMB, IVL
6cisplatin44 49 59 1114.3CCNG1, TP73, IFI27, YY1, GZMB, MKI67
7thymidine44 2412.2NME1, IFI27, MKI67, TERT, YY1, CFLAR
8vegf4411.2MKI67, GZMB, IVL, VEGFC, TERT, CDKN2A
9doxorubicin44 49 1113.2IFI27, CCNG1, MKI67, ODC1, TERC, CFLAR
10lipid4411.2VEGFC, MKI67, IVL, GZMB, IFI27, KRT8
115fluorouracil4411.2NME1, TP73, TERC, TERT, CDKN2A, MKI67
12progesterone44 59 28 11 2415.2TERC, VEGFC, IFI27, MKI67, NME1, CDKN2A
13steroid4411.2YY1, MKI67, KRT10, KRT8, IFI27, GZMB
14serine4411.2CCNG1, KRT17, CFLAR, NME1, MKI67, IVL
15testosterone44 59 11 2414.1MKI67, VEGFC, IFI27, CCNG1, ODC1, CFLAR
16nitric oxide44 11 2413.1YY1, MKI67, NME1, CFLAR, VEGFC, CDKN2A
17adriamycin4411.1TP73, TERC, TERT, KRT8, CFLAR, CDKN2A
18arginine4411.1TP73, TERT, KRT10, CDKN2A, GZMB, RBL1
19threonine4411.1KRT10, IFI27, TERT, TP73, KRT8, CCNG1
20retinoid4411.1KRT10, IVL, IFI27, ODC1, KRT8, CCNG1
21dexamethasone44 49 28 1114.1CCNG1, SPRR1B, NME1, CDKN2A, IFI27, VEGFC
22glucose4411.1VEGFC, CFLAR, YY1, IVL, GZMB, CCNG1
23paclitaxel44 49 1113.0TERT, ODC1, IFI27, CDKN2A, CFLAR, KRT8
24bromodeoxyuridine4411.0MKI67, KRT10, IFI27, KRT8, ODC1, IVL
25etoposide44 49 59 1114.0GZMB, CFLAR, CDC6, TERT, KRT8
26lactate4411.0MKI67, IVL, IFI27, ODC1, KRT8, NME1
27atp44 2812.0YY1, KRT8, CDC6, KRT17, CDKN2A, RBL1
28fatty acid4411.0IFI27, IVL, CDKN2A, NME1, KRT10, TP73
29oxygen44 2412.0IFI27, GZMB, IVL, MKI67, CDKN2A, CFLAR
30cysteine4411.0CDKN2A, IVL, ODC1, GZMB, NME1, CFLAR
31hematoxylin4411.0KRT8, MKI67, IVL, CDKN2A, KRT10
32rapamycin4411.0CCNG1, ODC1, IFI27, CFLAR, TERT, GZMB
33actinomycin d4411.0CCNG1, CDKN2A, CFLAR, KRT8, TP73, ODC1
34estrogen4411.0IVL
35thymidylate4410.9TERT, CDKN2A, MKI67, IFI27, ODC1
36p0024410.9TP73, MKI67, IFI27, CFLAR, NME1
37vincristine44 49 1112.9TP73, CFLAR, ODC1, MKI67
38butyrate4410.9YY1
39calcitriol44 59 11 2413.9NME1, KRT10, TERT, IVL, IFI27
40chloramphenicol44 2 1112.8IVL, ODC1, CDKN2A, TP73, YY1
41agar4410.8KRT8, NME1, CDKN2A, ODC1, TERC
42hpvs4410.8RBL1, YY1, CDKN2A
43chi 24410.8MKI67, NME1, IFI27
44acitretin44 1111.7ODC1, IVL, KRT17
45adpribose4410.7TERT, YY1, TERC, IFI27
46ribonucleic acid4410.7TERT, VEGFC, GZMB, NME1, ODC1
47camptothecin44 59 1112.6CFLAR, TP73, TERT, CDKN2A
48isotretinoin44 1111.6MKI67, KRT10, ODC1
49p000014410.5VEGFC, CDKN2A, MKI67
50gold4410.2KRT8, IVL

GO Terms for genes affiliated with Cervical Intraepithelial Neoplasia

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16Gene Ontology
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Cellular components related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.6KRT17, KRT8, KRT10
2cytoplasmGO:00573710.5SPRR1B, GZMB, IVL, MKI67, CDKN2A, CDC6

Biological processes related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratinizationGO:03142410.6SPRR1B, KRT17, IVL
2response to organonitrogen compoundGO:01024310.5TP73, CCNG1
3keratinocyte differentiationGO:03021610.5IVL, KRT10, SPRR1B
4replicative senescenceGO:09039910.2TERT, CDKN2A

Molecular functions related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9TP73, GZMB, RBL1, VEGFC, MKI67, CDKN2A

Products for genes affiliated with Cervical Intraepithelial Neoplasia

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Sources for Cervical Intraepithelial Neoplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet