Cervical Intraepithelial Neoplasia malady

Wikipedia: Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia and cervical interstitial...⁴⁴ more...

MalaCards: Cervical Intraepithelial Neoplasia, also known as CIN, is related to squamous cell carcinoma and breast cancer. An important gene associated with Cervical Intraepithelial Neoplasia is SPRR1B (small proline-rich protein 1B), and among its related pathways are Immune response Role of DAP12 receptors in NK cells and Cell cycle_Cell cycle (generic schema). The compounds egcg and roscovitine have been mentioned in the context of this disorder. Affiliated tissues include cervix, t cells and b cells, and related mouse phenotypes are respiratory system and craniofacial.

cervical intraepithelial neoplasia 30 32 43 cin 26

Diseases related to cervical intraepithelial neoplasia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 942)

id	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	36.7	RBP1, CD44, CDH1, MKI67, CCNA2, TP73
2	breast cancer	29.0	PIK3CA, RBP1, BMP6, CDK2, CDH1, ITGB4
3	vulvar cancer	28.2	VWF, CD44, IL2, IL6, MAPK1, TP53
4	hepatitis e	28.2	IFNA1, IFNG, EGFR, G6PD, STAT3, GGT1
5	hepatitis	28.0	GZMB, FASLG, FAS, IFNA1, IFNB1, HLA-A
6	papilloma	27.8	KIR3DL1, PCNA, RB1, RBL1, VEGFA, BIRC5
7	cervical squamous cell carcinoma	27.7	BIRC5, CLEC3B, BCL2, BAX, CEACAM7, CDKN1A
8	endocervicitis	26.8	BCL2, CEACAM7, CDKN1A, CDKN2A, MKI67, TP53
9	endometritis	26.4	VEGFA, CDKN2A, IL6, HLA-DQA1, HLA-DQB1
10	pancreatic cancer	25.8	VEGFA, BIRC5, CDKN1A, CDK2, ITGB4, FHIT
11	glucocorticoid resistance	25.6	BCL2, IL2, MAPK1, IFNA1, TNF
12	cervicitis	24.6	PIK3CA, KIAA0226L, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
13	conjunctivitis	24.6	RB1, VEGFA, BCL2, CDKN1A, CDKN2A, MMP9
14	cervical cancer	23.4	PIK3CA, PCNA, RB1, RBL1, VEGFA, VEGFC
15	cervical carcinoma	23.4	PIK3CA, PCNA, RB1, RBP1, RBL1, VEGFA
16	retinoblastoma	22.3	PIK3CA, PCNA, RB1, RBL1, VEGFA, VEGFC
17	carcinoma	21.8	PIK3CA, KIAA0226L, KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1
18	vaginitis	21.8	BCL2, BAX, S100B, MMP9, MKI67, IL2
19	neuroendocrine tumor	21.7	PIK3CA, RB1, VEGFA, BIRC5, BCL2, BAX
20	herpes simplex	21.6	PIK3CA, PCNA, VEGFA, BCL2, YY1, BAX
21	schizophrenia	20.8	PIK3CA, KIR3DL2, PCNA, VEGFA, BMP6, BCL2
22	pneumonia	17.6	VEGFA, VEGFC, BMP6, BCL2, LCN2, MTHFR
23	hypoxia	16.4	PIK3CA, VWF, PCNA, RB1, VEGFA, VEGFC
24	nephropathy	15.6	VWF, PCNA, RB1, VEGFA, VEGFC, BMP6
25	asthma	15.1	PIK3CA, PCNA, VEGFA, BMP6, BCL2, LCN2
26	colon cancer	14.4	PIK3CA, VWF, PCNA, RB1, RBL1, VEGFA
27	breast carcinoma	14.4	PIK3CA, VWF, PCNA, RB1, RBP1, VEGFA
28	epidermolysis bullosa simplex	14.1	IVL, ITGB4, KRT17, KRT1, KRT10, KRT15
29	bowen syndrome	14.0	PCNA, IVL, MKI67, KRT17, KRT1, KRT10
30	thyroid medullary carcinoma	14.0	VEGFC, MKI67, GZMB, FASLG, KRT8, KRT14
31	uterine sarcoma	14.0	CDK2, CDKN2A, MKI67, TERT, TYMP
32	neuronitis	14.0	PIK3CA, KIR2DS4, VWF, PCNA, RB1, RBL1
33	epidermolytic hyperkeratosis	14.0	IVL, SPRR1B, KRT1, KRT10
34	ovarian cancer	14.0	RB1, RBL1, CHEK2, CDKN1A, CDK2, CDKN2A
35	birdshot chorioretinopathy	13.9	KIR2DL1, KIR2DS4, KIR3DL1, HLA-A
36	trichoepithelioma	13.9	BCL2, CDH1, IVL, MKI67, KRT8, KRT17
37	adenocarcinoma in situ	13.9	CEACAM7, CDKN1A, CDKN2A, IFI27, TOP2A
38	acanthoma	13.8	PCNA, IVL, FGFR2, KRT1, KRT10
39	pancreatic ductal carcinoma	13.8	FASLG, KRT8, TYMP, TGM2
40	gestational trophoblastic neoplasm	13.8	PCNA, CGB5, HLA-G, TERC, NME1
41	anencephaly	13.8	MTRR, MTHFR, MTR, CGB5
42	primary cutaneous amyloidosis	13.8	BCL2, FAS, KRT17, KRT10
43	rectum sarcomatoid carcinoma	13.7	S100B, CDH1, MKI67, CYP1A1, KRT8, KRT1
44	parathyroid carcinoma	13.7	RB1, CGB5, MKI67, TP53, TERT, KRT14
45	pulmonary neuroendocrine tumor	13.7	RB1, CDKN2A, CDH1, MKI67, TP53, TERT
46	nodular melanoma	13.7	RB1, S100B, CDKN2A, MKI67, TP53
47	breast fibroadenoma	13.7	PCNA, VEGFC, MKI67, TP63, KRT8, KRT15
48	homocystinuria	13.7	MTRR, MTHFR, MTR, ABP1, G6PD
49	adenoameloblastoma	13.7	PCNA, MMP2, TERT, KRT8, KRT1, KRT14
50	recessive dystrophic epidermolysis bullosa	13.7	CDKN2A, IVL, TP53, KRT1, GGT1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cervical intraepithelial neoplasia:

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MGI Mouse Phenotypes related to cervical intraepithelial neoplasia:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	YY1, TP63, DLG1
2	craniofacial phenotype	MP:0005382	10.3	RBL1, FGFR2, TP73, DLG1, SMAD3, RPSA
3	embryogenesis phenotype	MP:0005380	9.7	RBL1, BIRC5, XRCC1, T, CFLAR, TP73
4	hematopoietic system phenotype	MP:0005397	9.6	PCNA, RBP1, RBL1, BCL2, CHEK2, LCN2
5	pigmentation phenotype	MP:0001186	9.4	RB1, RBP1, BCL2, CDKN2A, FGFR2, TP53
6	endocrine/exocrine gland phenotype	MP:0005379	9.2	IL2, FASLG, CCNA1, IFNG, TP63, DLG1
7	renal/urinary system phenotype	MP:0005367	9.2	BAX, LAMC2, CDKN1A, ITGB4, FGFR2, IFNAR1
8	other phenotype	MP:0005395	9.0	ST6GAL1, STAT3, NME1, TGIF1, HBB, PTGS2
9	limbs/digits/tail phenotype	MP:0005371	8.6	RB1, TERC, DLG1, SMAD3, CRABP1, KRT10
10	normal phenotype	MP:0002873	8.6	HLA-DQB1, STAT3, FASLG, ST6GAL1, IFNG, IFNB1
11	hearing/vestibular/ear phenotype	MP:0005377	8.5	CDKN1A, EGFR, KRT10, PLAU, E2F4, RB1
12	liver/biliary system phenotype	MP:0005370	8.4	RBP1, RBL1, VEGFA, IL2, IL6, CCNG1
13	integument phenotype	MP:0010771	8.3	RB1, RBL1, BCL2, YY1, KRT10, KRT14
14	no phenotypic analysis	MP:0003012	8.1	ST3GAL4, VEGFA, RBL1, PCNA, PTGS2, RB1
15	immune system phenotype	MP:0005387	7.0	TP53, TP63, TNF, TERC, TERT, SMAD2
16	digestive/alimentary phenotype	MP:0005381	7.0	DLG1, B2M, LAMC2, BCL2, VEGFA, RBL1
17	adipose tissue phenotype	MP:0005375	7.0	TP53, TNF, TERC, PTGS2, PLAU, EGFR
18	nervous system phenotype	MP:0003631	7.0	ITGB4, NME1, MMP2, FASLG, MAPK3, MAPK1
19	behavior/neurological phenotype	MP:0005386	6.6	RB1, SMAD3, TGM2, E2F4, IL6, IL2
20	skeleton phenotype	MP:0005390	6.3	RB1, RBL1, VEGFA, BMP6, CLEC3B, BAX
21	mortality/aging	MP:0010768	5.7	KRT17, KRT1, KRT10, KRT14, EGFR, G6PD
22	growth/size phenotype	MP:0005378	5.6	IL2, KRT8, KRT4, KRT10, EGFR, HBB
23	reproductive system phenotype	MP:0005389	5.4	MAPK1, CCNA1, IFNAR1, IFNG, CADM1, TP63
24	vision/eye phenotype	MP:0005391	4.8	IL6, GGT1, STAT3, TGFB1, FASLG, FAS
25	muscle phenotype	MP:0005369	4.5	EGFR, TGFB1, STAT3, VEGFA, MAPK1, PLAU
26	tumorigenesis	MP:0002006	4.4	PIK3CA, RB1, RBL1, BCL2, CHEK2, XRCC1
27	homeostasis/metabolism phenotype	MP:0005376	3.6	PIK3CA, VWF, RB1, RBP1, RBL1, VEGFA
28	cardiovascular system phenotype	MP:0005385	2.7	FGFR2, IL2, IL6, FASLG, FAS, MAPK3
29	cellular phenotype	MP:0005384	2.0	XRCC1, B2M, CFLAR, CDKN1A, CDK2, CDKN2A

Articles related to cervical intraepithelial neoplasia:

(show top 50)    (show all 132)

id	Title	Authors	Year	Affiliating Genes
1	Common polymorphisms in methylenetetrahydrofolate red uctase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. (21052817)	Tong S.Y.... Lee J.P.	2011	MTHFR
2	Decreased D2-40 and increased p16INK4A immunoreactivi ties correlate with higher grade of cervical intraepithelial neoplasia. (21729305)	Han H.... Lin Z.	2011	CDKN2A, PNMA2
3	Genetic variations of interleukin-1 and -6 genes and risk of cervical intraepithelial neoplasia. (21376376)	Grimm C.... Hefler L.	2011	IL6
4	High-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasia. (21309487)	Li Y.... Qiao Y.	2010	MIR218-1
5	Cervical intraepithelial neoplasia: Telomerase activi ty and splice pattern of hTERT mRNA. (20691751)	Petrenko A.A.... Kisseljov F.L.	2010	TERT
6	Up-regulation of lipocalin 2 is associated with high- risk human papillomavirus and grade of cervical lesion at baseline but does not predict outcomes of infections or incident cervical intraepithelial neoplasia. (20551266)	SyrjAonen S.... SyrjAonen K.	2010	LCN2
7	Expression of MMP-2, MMP-9, and urokinase-type plasmi nogen activator in cervical intraepithelial neoplasia. (19723042)	No J.H.... Song Y.S.	2009	MMP2, PLAU, MMP9
8	CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia. (18315605)	Smedts F.... Hopman A.H.	2008	CDKN2A
9	Extracellular regulated kinase-2 immunoreactivity increases in parallel with cervical intraepithelial neoplasia grade in cervical neoplasia. (17961162)	Kapetanios V.... Patsouris E.S.	2008	MAPK1, PSMC6
10	The utility of p16(Ink4a) in discriminating between cervical intraepithelial neoplasia 1 and nonneoplastic equivocal lesions of the cervix. (18466028)	Redman R.... Massoll N.A.	2008	CDKN2A
11	Chemiluminescent quantitative immunohistochemical p16 INK4A localization as a marker for cervical intraepithelial neoplasias. (18753961)	Venturoli S.... Musiani M.	2008	CDKN2A
12	Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia. (18223479)	Horn L.C.... Schmidt D.	2008	CDKN2A
13	Regulatory T cells in a spectrum of HPV-induced cervical lesions: cervicitis, cervical intraepithelial neoplasia and squamous cell carcinoma. (18593438)	Adurthi S.... Jayshree R.S.	2008	IL2RA, IL2
14	Glutathione-S-transferase M1 and T1 and cytochrome P1A1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women. (18090121)	Agorastos T.... Bontis J.N.	2007	CYP1A1, GSTT1, GSTM1
15	The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix. (17581402)	Hariri J.... A9ster A.	2007	CDKN2A
16	CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III). (17394499)	Regauer S.... Reich O.	2007	CDKN2A, TP63, KRT17
17	The expressions of the Rb pathway in cervical intraepithelial neoplasia; predictive and prognostic significance. (17046054)	Nam E.J.... Kim S.	2007	RB1
18	Relationship of up-regulation of 67-kd laminin receptor to grade of cervical intraepithelial neoplasia and to high-risk HPV types and prognosis in cervical cancer. (16514834)	Branca M.... Syrjanen K.	2006	RPSA
19	Methylation of p16INK4a is a non-rare event in cervical intraepithelial neoplasia. (16778587)	Kang S.... Cho N.H.	2006	CDKN2A
20	Relationship between cyclin G1 and human papilloma virus infection in cervical intraepithelial neoplasia and cervical carcinoma. (16845792)	Liang J.... Liu J.	2006	CCNG1
21	Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma. (16434060)	Zhou J.H.... Xie X.	2006	HLA-G
22	Expression of FasL in squamous cell carcinomas of the cervix and cervical intraepithelial neoplasia and its role in tumor escape mechanism. (16456813)	Ibrahim R.... Khleif S.N.	2006	FASLG
23	p14ARF and p16INK4A, two products of the same gene, are differently expressed in cervical intraepithelial neoplasia. (16406113)	Bulten J.... de Wilde P.C.	2006	CDKN2A
24	CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer. (16403567)	Taskiran C.... Ayhan A.	2006	CYP1A1
25	Aberrant expression of VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high risk HPV, but does not predict virus clearance after treatment of CIN or prognosis of cervical cancer. (16394279)	Branca M.... SyrjAonen K.	2006	VEGFC
26	Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers. (16679355)	Baak J.P.... Skaland I.	2006	KRT14
27	Expression of human papilloma virus (HPV) and P16ink4a in cervical intraepithelial neoplasia (CIN) and papilloma (16637315)	Vasilev I.... Stoianov S.	2006	CDKN2A
28	Over-expression of topoisomerase IIalpha is related to the grade of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HPV), but does not predict prognosis in cervical cancer or HPV clearance after cone treatment. (16990717)	Branca M.... Syrjanen K.	2006	TOP2A
29	Down-regulation of E-cadherin is closely associated with progression of cervical intraepithelial neoplasia (CIN), but not with high-risk human papillomavirus (HPV) or disease outcome in cervical cancer. (16800245)	Branca M.... SyrjAonen K.	2006	CDH1
30	A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia. (15730517)	Arnheim L.... Sanjeevi C.B.	2005	KIR3DL1, KIR2DL1, KIR2DL3
31	The p53 codon 72 polymorphism and risk of high-grade cervical intraepithelial neoplasia. (16122882)	Koushik A.... Franco E.L.	2005	TP53
32	Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3. (15514969)	Henao O.L.... Partridge E.E.	2005	MTR, MTHFR, MTRR
33	Granzyme B as a prognostic marker of cervical intraepithelial neoplasia. (15755009)	Kondo M.C.... Focchi J.	2005	GZMB
34	Functional attributes of mucosal immunity in cervical intraepithelial neoplasia and effects of HIV infection. (15374995)	Kobayashi A.... Smith-McCune K.K.	2004	T
35	FHIT (fragile histidine triad) gene analysis in cervical intraepithelial neoplasia. (11531281)	Liu F.S.... Lin A.J.	2001	FHIT
36	Tumor necrosis factor a-11 and DR15-DQ6 (B*0602) haplotype increase the risk for cervical intraepithelial neoplasia in human papillomavirus 16 seropositive women in Northern Sweden. (11045789)	Ghaderi M.... Sanjeevi C.B.	2000	TNF, HLA-B
37	Proliferative activity in cervical intraepithelial neoplasia and cervical carcinoma. (11593543)	Xue Y.... Zhang X.	1999	PCNA
38	Association between the HLA DQB1*0301 gene and human papillomavirus infection in high-grade cervical intraepithelial neoplasia. (12090587)	Lie A.K.... Ronningen K.S.	1999	HLA-DQB1
39	Decreased expression of retinoic acid receptors, transforming growth factor beta, involucrin, and cornifin in cervical intraepithelial neoplasia. (10389939)	Xu X.C.... Lotan R.	1999	BMP6, TGIF1, IVL
40	Epidermal growth factor receptor expression in cervical intraepithelial neoplasia and its modulation during an alpha-difluoromethylornithine chemoprevention trial. (9626454)	Boiko I.V.... Hittelman W.N.	1998	EGFR, ODC1
41	Phase I dose de-escalation trial of alpha-difluoromethylornithine in patients with grade 3 cervical intraepithelial neoplasia. (9516915)	Mitchell M.F.... Nishioka K.	1998	ODC1
42	CD44 expression in uterine cervical intraepithelial neoplasia and squamous cell carcinoma: an immunohistochemical study. (9476059)	Davidson B.... Kopolovic J.	1998	CD44
43	Induction of transforming growth factor beta-1 in cervical intraepithelial neoplasia in vivo after treatment with beta-carotene. (9815667)	Comerci J.T.... Goldberg G.L.	1997	TGFB1
44	Immunohistochemical study of thymidine phosphorylase in uterine cervical intraepithelial neoplasia (9170977)	Kaneoka A.... Takasu K.	1997	TYMP
45	p53 and human papilloma virus type 16 in cervical intraepithelial neoplasia and carcinoma. (8601524)	er Harmsel B.... Smedts F.	1995	TP53
46	Polyamines as biomarkers of cervical intraepithelial neoplasia. (8747382)	Nishioka K.... Mitchell M.F.	1995	ODC1
47	Intralesional beta-interferon treatment of cervical intraepithelial neoplasia associated with human papillomavirus infection. (8016908)	Penna C.... Marchionni M.	1994	IFNA1
48	Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia. (1372156)	Smedts F.... Vooijs P.	1992	KRT17
49	Human fibroblast interferon therapy alone and human fibroblast interferon combined with thymostimulin in genital papillomavirus infection associated with cervical intraepithelial neoplasia (1726446)	Grismondi G.L.... Rigoni I.	1991	IFNB1
50	Detection of a small molecular species of human chorionic gonadotropin in the urine of patients with carcinoma of the cervix and cervical intraepithelial neoplasia: comparison with other assays for human chorionic gonadotropin and its fragments. (2344970)	Norman R.J.... Moodley J.	1990	CGB5

Genes related to cervical intraepithelial neoplasia according to GeneCards:

(show top 50)    (show all 131)

id	Symbol	Description	Score	GeneCards Section Context
1	SPRR1B	small proline-rich protein 1B	11.0	Publications
2	CCNG1	cyclin G1	11.0	Publications
3	KRT17	keratin 17	11.0	Publications
4	CDC6	cell division cycle 6 homolog (S. cerevisiae)	11.0	Publications
5	KRT10	keratin 10	11.0	Publications
6	TERC	telomerase RNA component	11.0	Publications
7	RBL1	retinoblastoma-like 1 (p107)	11.0	Publications
8	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
9	ENPEP	glutamyl aminopeptidase (aminopeptidase A)	11.0
10	ODC1	ornithine decarboxylase 1	11.0	Publications
11	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
12	KRT8	keratin 8	11.0	Publications
13	YY1	YY1 transcription factor	11.0	Publications
14	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
15	IVL	involucrin	11.0	Publications
16	VEGFC	vascular endothelial growth factor C	11.0	Publications
17	CFLAR	CASP8 and FADD-like apoptosis regulator	11.0	Publications
18	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
19	TP73	tumor protein p73	11.0	Publications
20	TERT	telomerase reverse transcriptase	11.0	Publications
21	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
22	ITGB4	integrin, beta 4	11.0
23	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
24	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
25	MAPK3	mitogen-activated protein kinase 3	11.0	Publications
26	RB1	retinoblastoma 1	11.0	Publications
27	CHEK2	checkpoint kinase 2	11.0
28	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
29	CADM1	cell adhesion molecule 1	11.0
30	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0
31	CDK1	cyclin-dependent kinase 1	11.0
32	FHIT	fragile histidine triad	11.0	Publications
33	CDK2	cyclin-dependent kinase 2	11.0
34	MIR218-1	microRNA 218-1	11.0	Publications
35	HLA-S	major histocompatibility complex, class I, S (pseudogene)	11.0	Publications
36	TSPAN1	tetraspanin 1	11.0	Publications
37	PNMA2	paraneoplastic Ma antigen 2	11.0	Publications
38	FAM215A	family with sequence similarity 215, member A (non-protein coding)	11.0	Publications
39	CLEC3B	C-type lectin domain family 3, member B	11.0	Publications
40	KIR3DL3	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3	11.0	Publications
41	KRT15	keratin 15	11.0	Publications
42	KIR2DL4	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	11.0	Publications
43	CRABP1	cellular retinoic acid binding protein 1	11.0	Publications
44	CLDN2	claudin 2	11.0	Publications
45	T	T, brachyury homolog (mouse)	11.0	Publications
46	KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	11.0	Publications
47	KRT4	keratin 4	11.0	Publications
48	KIAA0226L	KIAA0226-like	11.0	Publications
49	PGD	phosphogluconate dehydrogenase	11.0	Publications
50	MCM5	minichromosome maintenance complex component 5	11.0	Publications

Pathways related to cervical intraepithelial neoplasia according to GeneDecks:

(show top 50)    (show all 200)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Role of DAP12 receptors in NK cells10	10.6	HLA-B, KIR2DL4, KIR2DL2, KIR2DL1
2	Cell cycle_Cell cycle (generic schema)41	10.4	CCNA2, CDK1, CDK2, RBL1, RB1, CCNA1
3	Cell cycle Cell cycle (generic schema)10	10.4	E2F4, CCNA1, CCNA2, CDK1, CDK2, RBL1
4	Breast Cancer Regulation by Stathmin136	10.3	E2F4, CCNG1, EGFR, FGFR2
5	Colorectal cancer20	10.3	SMAD3, TGFB1, SMAD2
6	Immune response_Role of DAP12 receptors in NK cells41	10.3	HLA-B, KIR2DL4, KIR2DL3, PIK3CA, KIR2DL1
7	Cell Cycle / Checkpoint Control3	10.2	CDK2, CDC6, CCNA2, TP73, TP63, CDK1
8	Glioma Invasiveness36	10.2	VEGFC, BMP6, CD44, ITGB4, PLAU
9	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.1	IL2, BCL2, GZMB, FASLG, IL2RA
10	p53 signaling pathway20	10.0	TP53, FAS, TP73, CDK1, CDKN2A, CDK2
11	G1-S Phase Transition36	9.9	CDKN1A, CDK2, CDKN2A, CCNA2, TP53, TGFB1
12	Antigen processing and presentation20	9.9	KIR3DL2, HLA-DQB1, HLA-DRB1, HLA-G, HLA-DQA1, HLA-DPB1
13	Cell cycle Regulation of G1/S transition (part 2)10	9.9	E2F4, CCNA1, CCNA2, MAPK1, MAPK3, CDK2
14	Cell cycle_Regulation of G1/S transition (part 2)41	9.9	RB1, RBL1, CDK2, MAPK3, MAPK1, CCNA2
15	Cyclins and Cell Cycle Regulation36	9.8	CDKN1A, E2F4, TGFB1, TP53, CCNA1, CCNA2
16	Cell cycle20	9.8	PCNA, RB1, RBL1, CHEK2, CDKN1A, SMAD3
17	Graft-versus-host disease20	9.7	KIR3DL2, HLA-DPB1, HLA-DQA1, HLA-G, KIR2DL1, KIR2DL3
18	Cell cycle Regulation of G1/S transition (part 1)10	9.7	CDKN2A, CDK2, CCNA2, TGFB1, SMAD3, SMAD2
19	Cell cycle_Regulation of G1/S transition (part 1)41	9.7	CHEK2, CDKN1A, CDK2, CDKN2A, CCNA2, CCNA1
20	Immune System38	9.5	KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR2DS4, KIR2DL2
21	Autoimmune thyroid disease20	9.1	HLA-B, HLA-DRB1, HLA-G, HLA-DQB1, HLA-DQA1, HLA-DPB1
22	Apoptosis Signaling Pathways37	8.9	BAX, BIRC5, TP53, HSPA4, FAS, CDKN1A
23	Immune response IL-22 signaling pathway10	8.7	MAPK1, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, MAPK3
24	Prostate cancer20	8.7	PIK3CA, EGFR, TP53, MAPK1, MAPK3, FGFR2
25	THC Differentiation Pathway36	8.6	HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNG, IFNAR2, IFNAR1
26	Immune response_IL-22 signaling pathway41	8.6	HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-DRB1, MAPK1, MAPK3
27	Measles20	8.5	IL2RA, STAT3, PIK3CA, IFNB1, IFNG, TP73
28	Mitochondrial Apoptosis36	8.4	IL6, TP53, VEGFC, BMP6, BCL2, EGFR
29	Melanoma20	8.3	PIK3CA, CDKN1A, CDKN2A, CDH1, MAPK3, MAPK1
30	Allograft rejection20	8.3	GZMB, HLA-G, HLA-DRB1, IL2, FASLG, FAS
31	Type I diabetes mellitus20	8.3	TNF, GZMB, FASLG, FAS, IFNG, HLA-A
32	p53 Mediated Apoptosis36	8.3	TP53, IL6, IL2RA, IL2, FGFR2, BAX
33	Bladder cancer20	8.3	TYMP, TP53, MMP2, RB1, VEGFA, EGFR
34	TGF-beta signaling pathway20	8.1	IFNG, BMP6, RBL1, MAPK3, MAPK1, TNF
35	Hepatitis C20	8.0	PIK3CA, CLDN2, CDKN1A, IFNA1, IFNAR1, IFNB1
36	Cellular Apoptosis Pathway36	8.0	CFLAR, CDKN2A, FGFR2, BMP6, BAX, CHEK2
37	Natural killer cell mediated cytotoxicity20	7.9	IFNA1, IFNAR1, IFNAR2, IFNB1, IFNG, HLA-B
38	Toxoplasmosis20	7.6	IFNG, BCL2, MAPK3, LAMC2, PIK3CA, MAPK1
39	Influenza A20	7.4	IFNG, IFNB1, IFNAR2, HLA-DPB1, HLA-DQA1, IFNAR1
40	Leishmaniasis20	7.4	HLA-DQA1, TGFB1, PTGS2, TNF, HLA-DPB1, IFNG
41	Molecular Mechanisms of Cancer36	7.3	RBL1, RB1, MAPK1, BMP6, CDK2, VEGFC
42	Immune response MIF-mediated glucocorticoid regulation10	7.2	IL6, IL2, PTGS2, TNF, IFNG, MAPK1
43	Tuberculosis20	7.2	HLA-DQA1, BCL2, TGFB1, TNF, BAX, IL6
44	Chagas disease (American trypanosomiasis)20	6.9	SMAD2, FAS, MAPK3, MAPK1, IFNG, TNF
45	Cytokine-cytokine receptor interaction20	6.9	IL2RA, IL6, VEGFA, VEGFC, IL2, IFNAR1
46	Immune response_MIF-mediated glucocorticoid regulation41	6.9	MAPK3, MAPK1, IL2, IFNG, TNF, PTGS2
47	Pathways in cancer20	6.7	STAT3, TGFB1, EGFR, SMAD2, TP53, CCNA1
48	JAK-STAT Pathway36	6.6	IFNAR2, PSMC6, STAT3, TGFB1, IL6, IL2RA
49	Pancreatic Adenocarcinoma36	6.4	CCNA2, CCNA1, CCNG1, TP53, PTGS2, EGFR
50	Colorectal Cancer Metastasis36	5.9	MAPK1, EGFR, TGFB1, STAT3, E2F4, IFNG

Compounds related to cervical intraepithelial neoplasia according to GeneDecks:

(show top 50)    (show all 410)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.6	CDK2, IVL, MAPK3, CAT, ODC1, RPSA
2	roscovitine32	10.5	PCNA, BIRC5, CDK1, MAPK3, CCNA2, IFI27
3	vincristine32 34 9 9	13.4	CGB5, MAPK3, IFNA1, IFNB1, ODC1, RPSA
4	dmso32	10.3	BMP6, CGB5, HSPA4, TP73, TERC, G6PD
5	h2o232	10.1	VWF, CGB5, FGFR2, IL2RA, CCNG1, IFNB1
6	camptothecin32 42 9 9	12.8	PCNA, RB1, BIRC5, BCL2, CHEK2, BAX
7	heparin32 9 18 9	12.7	PIK3CA, VWF, VEGFC, CLEC3B, CDK2, CDH1
8	p00232	9.6	RB1, BIRC5, MTHFR, XRCC1, CFLAR, CD44
9	atp32	9.3	PIK3CA, KIR3DL1, RB1, RBL1, BIRC5, CHEK2
10	rapamycin32 42	10.1	RB1, VEGFA, CHEK2, CFLAR, CDK2, CDK1
11	flavopiridol32 9 9	11.1	RB1, RBL1, VEGFA, BIRC5, BCL2, BAX
12	ascorbic acid32 18	10.0	PCNA, XRCC1, S100B, CGB5, MMP2, GSTM1
13	folate32	9.0	VWF, MTRR, MTHFR, MTR, XRCC1, B2M
14	indole-3-carbinol32	8.9	BIRC5, BCL2, BAX, CFLAR, CDKN1A, CDK2
15	bromodeoxyuridine32	8.8	PIK3CA, PCNA, RB1, BMP6, S100B, CDKN1A
16	trastuzumab32 34 9 9	11.8	PIK3CA, VEGFC, BIRC5, CDK2, FGFR2, FAS
17	progesterone32 42 9 18 9	12.6	PIK3CA, PCNA, RB1, RBP1, VEGFC, BIRC5
18	oxaliplatin32 34 9 9	11.5	VEGFA, BIRC5, MTHFR, XRCC1, CFLAR, CDKN1A
19	azathioprine32 34 9 9	11.5	PCNA, MTHFR, CDKN2A, CD44, CDH1, MMP2
20	etoposide32 42 9 9	11.4	PIK3CA, PCNA, RB1, BIRC5, BCL2, CHEK2
21	n acetylcysteine32	8.3	VWF, PCNA, BIRC5, CHEK2, CDKN1A, CDKN2A
22	mg 13232 42	9.3	PCNA, BIRC5, BAX, CFLAR, CDKN1A, CDK2
23	cysteine32	8.3	KIR2DS4, PCNA, MTHFR, MTR, S100B, CFLAR
24	irinotecan32 34 9 9	11.3	VEGFA, BAX, MTHFR, XRCC1, CFLAR, CDKN1A
25	temozolomide32 9 9	10.3	PCNA, VEGFA, CHEK2, XRCC1, CDKN1A, CDKN2A
26	cyclosporin a32 42	9.3	PIK3CA, VWF, MTHFR, S100B, B2M, CGB5
27	adpribose32	8.2	PIK3CA, PCNA, RB1, BIRC5, YY1, BAX
28	12-o-tetradecanoylphorbol 13-acetate32	8.1	RB1, BMP6, CDKN1A, CDK1, CD44, CDH1
29	docetaxel32 34 9 9	10.9	VEGFA, BIRC5, BCL2, BAX, CFLAR, CDKN1A
30	gemcitabine32 34 9 9	10.9	PCNA, VEGFA, BIRC5, BCL2, CHEK2, BAX
31	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	7.8	PCNA, BCL2, BAX, S100B, MMP2, MMP9
32	thymidylate32	7.8	PCNA, RB1, VEGFA, BIRC5, BCL2, BAX
33	alanine32	7.7	VWF, PCNA, RBL1, BMP6, BIRC5, CHEK2
34	glutamate32	7.6	PIK3CA, PCNA, BMP6, YY1, MTRR, MTHFR
35	gefitinib32 34 9 9	10.4	PIK3CA, VEGFA, BIRC5, CEACAM7, CDKN1A, CDK2
36	methotrexate32 34 42 9 9	11.4	PCNA, RB1, BMP6, BIRC5, MTRR, MTHFR
37	tgf beta132	7.3	RBL1, BMP6, CDKN1A, CDK2, CDH1, MMP2
38	phosphatidylinositol32	7.3	PIK3CA, RB1, RBL1, VEGFC, BMP6, BIRC5
39	thalidomide32 42 9 9	10.1	VEGFA, BIRC5, B2M, FGFR2, IL2, IL6
40	resveratrol32 9 18 9	9.8	PIK3CA, PCNA, RB1, VEGFA, BIRC5, BCL2
41	testosterone32 9 18 9	9.7	PIK3CA, VWF, PCNA, RB1, VEGFC, BIRC5
42	15-deoxy-delta-12,14-prostaglandin j232	6.6	VEGFA, BMP6, BIRC5, CDKN1A, CDK2, IL6
43	troglitazone32 42 9 9	9.5	RB1, BMP6, BIRC5, BCL2, BAX, CFLAR
44	creatinine32	6.5	VWF, PCNA, BMP6, LCN2, MTHFR, MTR
45	ly29400232	6.4	PIK3CA, VEGFA, CFLAR, CDK1, CD44, CDH1
46	vegf32	6.1	PIK3CA, VWF, PCNA, VEGFC, BCL2, S100B
47	pdtc32	5.9	PIK3CA, BIRC5, BCL2, CFLAR, CDKN1A, MMP2
48	curcumin32	5.2	VEGFA, BIRC5, BCL2, BAX, CDKN1A, CDK2
49	thymidine32 18	5.7	PIK3CA, PCNA, RB1, RBL1, VEGFC, BMP6
50	tyrosine32	3.8	PIK3CA, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1, VWF

Cellular components related to cervical intraepithelial neoplasia according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	10.7	KRT17, NME1, KRT14, KRT15, KRT10, KRT1
2	MHC class II protein complex	GO:042613	10.1	HLA-DRB1, HLA-DPB1, HLA-DQA1, HLA-DQB1
3	clathrin-coated endocytic vesicle membrane	GO:030669	10.0	HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-DRB1
4	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-A, HLA-G
5	Golgi membrane	GO:000139	9.9	HLA-DQA1, ST3GAL3, ST6GAL1, ST3GAL4, HLA-DPB1, HLA-DQB1
6	ER to Golgi transport vesicle membrane	GO:012507	9.9	HLA-DQA1, HLA-G, HLA-DRB1, HLA-DQB1, HLA-DPB1, HLA-B
7	MHC class I protein complex	GO:042612	9.8	B2M, HLA-G, HLA-B, HLA-A
8	nucleoplasm	GO:005654	8.8	PCNA, CCNA2, CCNA1, TP53, TERT, SMAD2
9	external side of plasma membrane	GO:009897	8.7	TNF, VWF, CD44, ENPEP, IFNG, FAS
10	cytosol	GO:005829	7.2	G6PD, BIRC5, BCL2, BAX, MTRR, MTHFR
11	cytoplasm	GO:005737	6.7	TP53, STAT3, POU2F3, NME1, VEGFA, RBP1
12	plasma membrane	GO:005886	6.6	HLA-DQB1, HLA-DRB1, HLA-DPB1, HLA-G, HLA-DQA1, STAT3
13	extracellular space	GO:005615	6.4	VEGFC, FASLG, IL6, IL2, MMP9, MMP2
14	extracellular region	GO:005576	6.4	B2M, S100B, LAMC2, LCN2, CLEC3B, VEGFA

Biological processes related to cervical intraepithelial neoplasia according to GeneDecks:

(show top 50)    (show all 57)

id	Name	GO ID	Score	Top Affiliating Genes
1	epidermis development	GO:008544	10.8	KRT1, KRT10, KRT15, KRT14, POU2F3, CDKN2A
2	regulation of transcription involved in G1/S phase of mitotic cell cycle	GO:000083	10.8	CDC6, RB1, CDK1, CCNA1, E2F4, PCNA
3	DNA replication	GO:006260	10.6	CDK2, CDC6, FHIT, CDK1, TOP2A, TYMP
4	mitotic cell cycle G2/M transition DNA damage checkpoint	GO:007095	10.6	CCNG1, CCNA2, CDK1
5	replicative senescence	GO:090399	10.5	TP53, CDKN2A, CDKN1A, CHEK2, TERT
6	cell cycle checkpoint	GO:000075	10.5	CDKN1A, CDK2, CDKN2A, CDC6, CDK1, MCM5
7	G1 phase of mitotic cell cycle	GO:000080	10.5	CDKN1A, CDKN2A, RB1, RBL1, E2F4
8	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.5	B2M, HLA-B, HLA-G, HLA-A
9	mitotic cell cycle	GO:000278	10.4	E2F4, PCNA, RB1, RBL1, PSMC6, TOP2A
10	G1/S transition of mitotic cell cycle	GO:000082	10.4	RB1, CDK1, CDC6, CDKN2A, CDK2, CDKN1A
11	type I interferon-mediated signaling pathway	GO:060337	10.4	IFI27, IFNAR1, IFNAR2, HLA-B, HLA-G, IFNB1
12	release of cytochrome c from mitochondria	GO:001836	10.3	TP53, TP73, SMAD3, BAX, BCL2
13	S phase of mitotic cell cycle	GO:000084	10.3	RB1, PSMC6, MCM5, CDC6, CDK2, CDKN1A
14	G2/M transition of mitotic cell cycle	GO:000086	10.3	CCNA2, CDK1, CDKN1A, CHEK2, CDK2, CCNA1
15	activation of pro-apoptotic gene products	GO:008633	10.2	BAX, SMAD3, IFI27, FAS, FASLG, GZMB
16	response to DNA damage stimulus	GO:006974	10.2	CDKN1A, CHEK2, BAX, TP53, BCL2, TP73
17	neuron apoptotic process	GO:051402	10.1	BAX, BCL2, TP53, TP63, FAS, RB1
18	negative regulation of mitotic cell cycle	GO:045930	10.0	TGFB1, SMAD3, DLG1, BCL2
19	regulation of binding	GO:051098	10.0	SMAD3, SMAD2, TGFB1
20	regulation of immune response	GO:050776	9.9	KIR3DL2, HLA-A, CDH1, KIR2DL2, KIR2DL4, KIR2DL3
21	transforming growth factor beta receptor signaling pathway	GO:007179	9.9	RBL1, TGIF1, TGFB1, SMAD3, SMAD2, E2F4
22	positive regulation of epithelial cell proliferation	GO:050679	9.8	VEGFC, EGFR, FGFR2, TGFB1, NME1, BMP6
23	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.7	BAX, IFI27, TNF, SMAD3, CDKN2A, FAS
24	negative regulation of cell growth	GO:030308	9.7	RB1, SMAD3, TP53, TGFB1, CDKN2A, CDKN1A
25	Ras protein signal transduction	GO:007265	9.7	RB1, TP53, CCNA2, MAPK1, MAPK3, CDK1
26	response to toxin	GO:009636	9.7	CDH1, CDK1, CDKN1A, BAX, BCL2, FAS
27	induction of apoptosis by intracellular signals	GO:008629	9.5	BAX, BCL2, GZMB, TP53, CDKN1A
28	transformed cell apoptotic process	GO:006927	9.5	FAS, TNF, BAX
29	positive regulation of cell division	GO:051781	9.5	CAT, FGFR2, TGFB1, VEGFC, VEGFA
30	interferon-gamma-mediated signaling pathway	GO:060333	9.5	HLA-DQB1, HLA-G, B2M, CD44, IFNG, HLA-A
31	cell cycle arrest	GO:007050	9.4	RB1, TP73, CDKN1A, CDKN2A, IFNG, TP53
32	humoral immune response	GO:006959	9.2	IL6, IFNG, IFNB1, TNF, BCL2, ST6GAL1
33	anti-apoptosis	GO:006916	9.1	CFLAR, TERT, TNF, FAS, IL2, CDK1
34	immune response	GO:006955	9.1	HLA-DQA1, HLA-DQB1, HLA-DRB1, IL2RA, KIR3DL1, BMP6
35	virus-host interaction	GO:019048	9.0	DLG1, TP53, HLA-A, MAPK3, CFLAR, BAX
36	positive regulation of peptidyl-serine phosphorylation	GO:033138	8.8	TGFB1, PIK3CA, TNF, VEGFA, BCL2, CD44
37	cytokine-mediated signaling pathway	GO:019221	8.8	HLA-B, STAT3, HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1
38	positive regulation of nitric oxide biosynthetic process	GO:045429	8.7	IFNG, PTGS2, EGFR, TNF, HBB
39	MAPK cascade	GO:000165	8.7	EGFR, MAPK3, TGFB1, TNF, MAPK1, CDK1
40	positive regulation of transcription, DNA-dependent	GO:045893	8.7	TP63, TP73, TP53, RB1, CCNA2, TNF
41	response to hypoxia	GO:001666	8.7	MMP9, FAS, TGFB1, ANG, CAT, VEGFA
42	positive regulation of cell proliferation	GO:008284	8.6	IL6, IL2, CDK2, FASLG, DLG1, EGFR
43	negative regulation of apoptotic process	GO:043066	8.5	BCL2, VEGFA, EGFR, SMAD3, TNF, TP53
44	positive regulation of apoptotic process	GO:043065	8.4	TOP2A, TNF, BAX, MMP9, FASLG, FAS
45	induction of apoptosis	GO:006917	8.3	TGM2, BAX, TGFB1, CDKN2A, FASLG, IFNB1
46	negative regulation of cell proliferation	GO:008285	8.2	CDKN1A, NME1, TGFB1, SMAD2, PTGS2, TNF
47	blood coagulation	GO:007596	7.8	TP53, PLAU, HBB, TGFB1, IFNB1, MAPK1
48	apoptotic process	GO:006915	7.5	FAS, MAPK3, MAPK1, IFNG, CADM1, TP53
49	response to drug	GO:042493	7.3	IFNG, NME1, PTGS2, ABP1, TOP2A, TGFB1
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.3	TNF, RB1, TOP2A, TGFB1, STAT3, E2F4

Molecular functions related to cervical intraepithelial neoplasia according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:032395	10.1	HLA-DQA1, HLA-DQB1, HLA-DRB1, KRT17
2	transcription factor binding	GO:008134	10.0	E2F4, SMAD3, SMAD2, TP73, TP53, CDKN2A
3	protein kinase binding	GO:019901	9.8	TP53, CHEK2, STAT3, SMAD3, DLG1, TP73
4	phosphatase binding	GO:019902	9.1	SMAD2, SMAD3, MAPK1, DLG1, MAPK3
5	identical protein binding	GO:042802	8.7	EGFR, PCNA, BIRC5, CLDN2, BCL2, BAX
6	protein homodimerization activity	GO:042803	8.1	S100B, CHEK2, BCL2, BIRC5, VEGFA, VWF
7	cytokine activity	GO:005125	7.9	VEGFA, TNF, IFNG, IFNB1, FASLG, IL6
8	protein binding	GO:005515	4.2	GGT1, CADM1, HLA-A, TP53, TP63, TP73