CIN
MCID: CRV045
MIFTS: 45

Cervical Intraepithelial Neoplasia (CIN) malady

Rare diseases category
Download this MalaCard

Summaries for Cervical Intraepithelial Neoplasia

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia and cervical interstitial... more...

MalaCards: Cervical Intraepithelial Neoplasia, also known as CIN, is related to cervical cancer and papilloma. An important gene associated with Cervical Intraepithelial Neoplasia is TERC (telomerase RNA component), and among its related pathways are Granzyme Pathway and Apoptosis. The compounds hematoxylin and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and t cells, and related mouse phenotypes are integument and embryogenesis.

Aliases & Classifications for Cervical Intraepithelial Neoplasia

About this section
Sources:
43NIH Rare Diseases, 45Novoseek, 62UMLS, 39NCBI Bookshelf
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

cervical intraepithelial neoplasia 43 45 62
cin 39


Related Diseases for Cervical Intraepithelial Neoplasia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cervical Intraepithelial Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1cervical cancer31.4CDKN2A, CDC6, TERT, TERC, VEGFC, YY1
2papilloma31.2ODC1, KRT10, CDKN2A
3cervical squamous cell carcinoma30.9CDKN2A, KRT10, MKI67
4adenocarcinoma30.6TERC, MKI67, CFLAR, VEGFC, ODC1, NME1
5retinoblastoma30.5TERT, TERC, MKI67, ODC1, YY1, NME1
6colorectal cancer29.6TERT, TERC, CFLAR, VEGFC, ODC1, NME1
7cervicitis11.6
8vaginitis10.7
9endocervicitis10.6
10adenocarcinoma in situ10.6
11hiv-110.5
12bacterial vaginosis10.5
13conjunctivitis10.4
14vaginal cancer10.4
15blindness10.4
16vulvar intraepithelial neoplasia10.4
17endotheliitis10.4
18cervix uteri carcinoma in situ10.2
19ovarian squamous cell carcinoma10.2
20epidermodysplasia verruciformis10.2
21obesity10.2
22ovarian cyst10.2
23papillary adenocarcinoma10.2
24peritonitis10.2
25bowenoid papulosis10.2
26drug addiction10.2
27steatocystoma multiplex10.1KRT10, KRT17
28palmoplantar keratosis10.1KRT17, KRT10
29epidermolysis bullosa simplex10.1KRT17, KRT10
30cervical adenocarcinoma10.1CDKN2A, NME1
31gestational trophoblastic neoplasm10.1NME1, TERC
32lung cancer10.1CDKN2A, VEGFC
33smooth muscle tumor10.1MKI67, NME1
34aplastic anemia10.1TERC
35bowen syndrome10.1KRT10, KRT17, MKI67
36endometrial carcinoma10.1NME1, CDKN2A
37pulmonary fibrosis, familial10.0TERT, TERC
38anaplastic astrocytoma10.0CDKN2A, ODC1, MKI67
39dyskeratosis congenita autosomal dominant10.0TERC, TERT
40ependymoma10.0MKI67, TERC
41lichen planus10.0KRT10, GZMB
42follicular thyroid carcinoma10.0VEGFC, NME1
43tongue squamous cell carcinoma10.0NME1, ODC1, MKI67
44bladder transitional cell carcinoma10.0MKI67, VEGFC
45dyskeratosis congenita10.0TERC, TERT
46gastritis10.0TERT, TERC
47peripheral t-cell lymphoma10.0GZMB, NME1
48seminoma10.0NME1, VEGFC, TERC
49intraocular melanoma10.0CDKN2A, NME1, VEGFC
50esophageal cancer10.0VEGFC, NME1, CDKN2A

Graphical network of the top 20 diseases related to Cervical Intraepithelial Neoplasia:



Diseases related to cervical intraepithelial neoplasia

Symptoms for Cervical Intraepithelial Neoplasia

About this section

Drugs & Therapeutics for Cervical Intraepithelial Neoplasia

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Cervical Intraepithelial Neoplasia

Search NIH Clinical Center for Cervical Intraepithelial Neoplasia

Genetic Tests for Cervical Intraepithelial Neoplasia

About this section

Anatomical Context for Cervical Intraepithelial Neoplasia

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cervical Intraepithelial Neoplasia:

33
Cervix, Testes, T cells, Endothelial, Monocytes

Animal Models for Cervical Intraepithelial Neoplasia or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Cervical Intraepithelial Neoplasia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5TERC, YY1, NME1, KRT17, KRT10, CDKN2A
2MP:00053808.2TERC, CFLAR, ODC1, YY1, NME1, CDKN2A
3MP:00020068.1TERT, TERC, NME1, GZMB, KRT10, CDKN2A
4MP:00053977.8CDKN2A, GZMB, NME1, CFLAR, TERC, TERT
5MP:00053787.2TERT, TERC, CFLAR, YY1, NME1, KRT10
6MP:00053877.1TERT, TERC, CFLAR, VEGFC, GZMB, KRT10
7MP:00053847.1TERT, TERC, CFLAR, ODC1, YY1, GZMB
8MP:00053766.8TERT, TERC, CFLAR, VEGFC, YY1, NME1
9MP:00107685.6CDKN2A, TERT, TERC, CFLAR, VEGFC, ODC1

Publications for Cervical Intraepithelial Neoplasia

About this section
Sources:
52PubMed
See all sources

Articles related to Cervical Intraepithelial Neoplasia:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Women whose cervical intraepithelial neoplasia has been treated or resolved remain at continued high risk for cervical cancer. (23378629)
2013
2
Stathmin-1 expression as a complement to p16 helps identify high-grade cervical intraepithelial neoplasia with increased specificity. (23211296)
2013
3
Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia across 5 countries in Asia. (23221730)
2013
4
Is vaccination with quadrivalent HPV vaccine after loop electrosurgical excision procedure effective in preventing recurrence in patients with high-grade cervical intraepithelial neoplasia (CIN2-3)? (23623831)
2013
5
Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study. (23095878)
2013
6
Use of the NucliSENS EasyQ HPV assay in the management of cervical intraepithelial neoplasia. (23918542)
2013
7
Results of pap smears and immunocytochemical detection of the p16 and Ki67 proteins in women with cervical intraepithelial neoplasia and cervical cancer]. (23379189)
2012
8
Overexpression of c-Met in cervical intraepithelial neoplasia. (23327059)
2012
9
Molecular mapping of high-grade cervical intraepithelial neoplasia shows etiological dominance of HPV16. (22419273)
2012
10
Inpatient and outpatient loop electrosurgery excision procedure for cervical intraepithelial neoplasia: a retrospective analysis. (22116315)
2012
11
Genomic amplification of hTERC in paraffin-embedded tissues of cervical intraepithelial neoplasia and invasive cancer. (22498947)
2012
12
Number of fragments, margin status and thermal artifacts of conized specimens from LLETZ surgery to treat cervical intraepithelial neoplasia. (22481754)
2012
13
The role of mRNA E6/E7 HPV high oncogenic risk expression in colposcopy of cervical intraepithelial neoplasia (CIN). (23401983)
2012
14
Factors affecting the clearance of high-risk human papillomavirus infection and the progression of cervical intraepithelial neoplasia. (22613409)
2012
15
Quality of life among Thai women diagnosed with cervical cancer and cervical intraepithelial neoplasia at King Chulalongkorn Memorial Hospital. (21863670)
2011
16
Cytokine serum levels in patients with cervical intraepithelial neoplasia grade II-III treated with intralesional interferon-I+ 2b. (22158487)
2011
17
Twelve-month follow-up detection of high-risk human papillomavirus (HPV) DNA for 93 cases with cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3) after a loop electrosurgical excisional procedure (LEEP). (21614905)
2011
18
A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia. (20945322)
2011
19
IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer. (21997684)
2011
20
Increased serum progesterone and estradiol correlate to increased COX-2 tissue expression in cervical intraepithelial neoplasia. (20530431)
2010
21
Prospective study of the association of serum gamma-glutamyltransferase with cervical intraepithelial neoplasia III and invasive cervical cancer. (20388786)
2010
22
Endocervicoscopy: a new technique for the diagnostic work-up of cervical intraepithelial neoplasia allowing a tailored excisional therapy in young fertile women. (20451182)
2010
23
p16INK4a and low-grade cervical intraepithelial neoplasia. Diagnostic and therapeutic implications. (20882883)
2010
24
Use of various contraceptives and human papillomavirus 16 and 18 infections in women with cervical intraepithelial neoplasia. (20606223)
2010
25
Incidence and costs of cervical intraepithelial neoplasia in a US commercially insured population. (20040833)
2010
26
Cervical intraepithelial neoplasia recurrence after conization in HIV-positive and HIV-negative women. (19062013)
2009
27
Plasma proteome analysis of cervical intraepithelial neoplasia and cervical squamous cell carcinoma. (20093745)
2009
28
Epithelial and stromal metabolite changes in the transition from cervical intraepithelial neoplasia to cervical cancer: an in vivo 1H magnetic resonance spectroscopic imaging study with ex vivo correlation. (19259678)
2009
29
IFNG (+874 T/A) polymorphism and cervical intraepithelial neoplasia in Brazilian women. (19232001)
2009
30
Recurrent rates with cervical intraepithelial neoplasia having a negative surgical margin after the loop electrosurgical excision procedure in Thailand. (19827874)
2009
31
The diagnostic accuracy of colposcopy in previously treated cervical intraepithelial neoplasia. (19098599)
2009
32
Medical treatment of cervical intraepithelial neoplasia II, III: an update review. (19225922)
2009
33
Follow-up after treatment of cervical intraepithelial neoplasia by human papillomavirus genotyping. (19344881)
2009
34
Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. (18482945)
2008
35
The utility of p16(Ink4a) in discriminating between cervical intraepithelial neoplasia 1 and nonneoplastic equivocal lesions of the cervix. (18466028)
2008
36
Neutralizing antibodies against human papillomavirus types 16, 18, 31, 52, and 58 in serum samples from women in Japan with low-grade cervical intraepithelial neoplasia. (18753335)
2008
37
Effectiveness, safety, and acceptability of cryotherapy by midwives for cervical intraepithelial neoplasia in Maharashtra, India. (18817909)
2008
38
Frequency of cervical intraepithelial neoplasia and infectious agents for vaginitis in menstrual cycle phase. (17966219)
2007
39
Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status. (17303386)
2007
40
Glutathione-S-transferase M1 and T1 and cytochrome P1A1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women. (18090121)
2007
41
The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix. (17581402)
2007
42
Increased apoptosis in cervical intraepithelial neoplasia associated with HIV infection: implication of oncogenic human papillomavirus, caspases, and Langerhans cells. (15814619)
2005
43
Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer. (15923164)
2005
44
Misdiagnosis of high-grade vulvar intraepithelial neoplasia (VIN III) as mild cervical intraepithelial neoplasia (CIN I) on Papanicolaou tests. (12521370)
2003
45
Expression of the cell cycle regulator p27(Kip1) in normal squamous epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma of the uterine cervix. Immunohistochemistry and functional aspects of p27(Kip1). (11753978)
2001
46
Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia. (10928104)
2000
47
Increased carcinoembryonic antigen expression in cervical intraepithelial neoplasia grade 3 and in cervical squamous cell carcinoma. (11112209)
2000
48
Progressing imbalance between proliferation and apoptosis with increasing severity of cervical intraepithelial neoplasia. (9421084)
1997
49
An immunohistochemical study of p53 protein in cervical intraepithelial neoplasia and squamous cell carcinoma. (8714263)
1996
50
Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia. (1637668)
1992

Variations for Cervical Intraepithelial Neoplasia

About this section

Expression for genes affiliated with Cervical Intraepithelial Neoplasia

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cervical Intraepithelial Neoplasia

Search GEO for disease gene expression data for Cervical Intraepithelial Neoplasia.

Pathways for genes affiliated with Cervical Intraepithelial Neoplasia

About this section
Sources:
50PathCards, 53QIAGEN, 55Reactome, 38NCBI BioSystems Database, 5Cell Signaling Technology, 60Thomson Reuters, 30KEGG
See all sources

Pathways related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GZMB, NME1
2
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.2CDKN2A, CFLAR, GZMB
3
Show member pathways
9.0YY1, MKI67, CDC6, CDKN2A
49.0CFLAR, GZMB, YY1
58.9TERT, NME1, ODC1
6
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.9CFLAR, ODC1, GZMB, CDC6
7
Show member pathways
8.3VEGFC, TERT, CDKN2A, CFLAR

Compounds for genes affiliated with Cervical Intraepithelial Neoplasia

About this section
Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1hematoxylin459.8MKI67, CDKN2A, KRT10
2isotretinoin45 1110.8KRT10, ODC1, MKI67
3dutp459.6KRT10, CFLAR, MKI67
4biotin45 24 1111.6CDKN2A, NME1, MKI67
5lipofectamine459.6TERC, TERT
6irinotecan45 51 1111.6MKI67, CDKN2A, CFLAR
7p00001459.5MKI67, CDKN2A, VEGFC
8agar459.5CDKN2A, NME1, ODC1, TERC
9p002459.4NME1, CFLAR, MKI67
10vincristine45 51 1111.3ODC1, CFLAR, CDKN2A, MKI67
11depsipeptide459.2CDKN2A, TERT, CFLAR
12fatty acid459.2CDKN2A, NME1, MKI67, KRT10
13glyceraldehyde 3-phosphate459.2NME1, KRT10, ODC1, VEGFC
14tin(2+)459.1TERC, TERT
15adpribose459.1TERC, TERT, YY1
16egcg459.0CDKN2A, ODC1, TERT
17thymidylate459.0ODC1, CDKN2A, TERT, MKI67
18lactate458.8MKI67, GZMB, NME1, ODC1
19camptothecin45 61 1110.8CFLAR, CDKN2A, TERT
20adriamycin458.7CFLAR, TERT, ODC1, CDKN2A, TERC
21dexamethasone45 51 29 1111.7KRT10, VEGFC, GZMB, NME1, CDKN2A
22progesterone45 29 61 24 1112.7TERC, CDKN2A, KRT10, MKI67, NME1, VEGFC
23butyrate458.6CDKN2A, ODC1, TERC, YY1, TERT
24rapamycin458.6CFLAR, ODC1, TERT, GZMB
25atp45 299.6CDKN2A, YY1, NME1, CDC6, KRT17, GZMB
26paclitaxel45 51 1110.5CDKN2A, ODC1, CFLAR, MKI67, TERT
27steroid458.5CDKN2A, NME1, GZMB, YY1, MKI67, KRT10
28threonine458.4MKI67, CFLAR, CDKN2A, TERT, KRT10
295fluorouracil458.3CDKN2A, TERT, TERC, MKI67, CFLAR, NME1
30ly294002458.3TERT, CFLAR, GZMB, VEGFC
31doxorubicin45 51 1110.3TERC, TERT, MKI67, CFLAR, ODC1, CDKN2A
32etoposide45 51 61 1111.2CFLAR, TERT, GZMB, TERC, CDC6, NME1
33ribonucleic acid458.2GZMB, NME1, ODC1, VEGFC, TERT
34arginine458.1CDKN2A, GZMB, KRT10, ODC1, MKI67, TERT
35cysteine458.0NME1, GZMB, CFLAR, CDKN2A, TERT, ODC1
36glucose458.0YY1, CFLAR, MKI67, VEGFC, GZMB, CDKN2A
37testosterone45 61 24 1110.9ODC1, CFLAR, VEGFC, MKI67, TERT, CDKN2A
38oxygen45 248.7VEGFC, CDKN2A, GZMB, CFLAR, MKI67, TERT
39lipid457.5GZMB, VEGFC, TERC, TERT, CDKN2A, CFLAR
40vegf457.4CDKN2A, TERT, VEGFC, CFLAR, MKI67, GZMB
41cisplatin45 51 61 1110.3GZMB, NME1, MKI67, CDKN2A, TERT, TERC
42thymidine45 248.1MKI67, NME1, YY1, ODC1, VEGFC, CFLAR
43serine457.1NME1, CDKN2A, KRT10, KRT17, GZMB, CFLAR
44tyrosine456.7GZMB, NME1, VEGFC, ODC1, CFLAR, MKI67
45paraffin456.7NME1, KRT17, CDKN2A, TERT, TERC, MKI67
46calcium45 51 24 119.6GZMB, CFLAR, VEGFC, NME1, TERT, YY1
47nitric oxide45 24 118.6CDKN2A, MKI67, TERT, CFLAR, GZMB, VEGFC
48oligonucleotide456.5TERT, CDKN2A, GZMB, KRT17, NME1, YY1
49estrogen456.5KRT10, CDKN2A, TERT, TERC, GZMB, NME1
50retinoic acid45 247.2TERC, CFLAR, VEGFC, ODC1, NME1, GZMB

GO Terms for genes affiliated with Cervical Intraepithelial Neoplasia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.2ODC1, NME1, GZMB, CDC6, CDKN2A, CFLAR
2cytoplasmGO:0057376.4CDKN2A, TERT, MKI67, CFLAR, NME1, GZMB

Biological processes related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.4CDKN2A, TERT

Molecular functions related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.9CDKN2A, MKI67, CFLAR, VEGFC, YY1, NME1

Products for genes affiliated with Cervical Intraepithelial Neoplasia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cervical Intraepithelial Neoplasia

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet