CIN
MCID: CRV045
MIFTS: 46

Cervical Intraepithelial Neoplasia (CIN) malady

Rare diseases category
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Summaries for Cervical Intraepithelial Neoplasia

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Wikipedia:65 Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia and cervical interstitial... more...

MalaCards based summary: Cervical Intraepithelial Neoplasia, also known as CIN, is related to papilloma and cervical squamous cell carcinoma. An important gene associated with Cervical Intraepithelial Neoplasia is TERC (telomerase RNA component), and among its related pathways are Granzyme Pathway and Apoptosis. The compounds hematoxylin and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and t cells, and related mouse phenotypes are integument and embryogenesis.

Aliases & Classifications for Cervical Intraepithelial Neoplasia

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Cervical Intraepithelial Neoplasia, Aliases & Descriptions:

Name: Cervical Intraepithelial Neoplasia 42 44 62
 
Cin 38


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Cervical Intraepithelial Neoplasia

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Diseases related to Cervical Intraepithelial Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma31.5ODC1, KRT10, CDKN2A
2cervical squamous cell carcinoma31.2CDKN2A, KRT10, MKI67
3cervical cancer30.3CDKN2A, CDC6, TERT, TERC, VEGFC, YY1
4retinoblastoma29.6TERT, TERC, MKI67, ODC1, YY1, NME1
5adenocarcinoma29.2TERC, MKI67, CFLAR, VEGFC, ODC1, NME1
6colorectal cancer28.6TERT, TERC, CFLAR, VEGFC, ODC1, NME1
7cervicitis11.7
8endocervicitis10.7
9vaginitis10.7
10adenocarcinoma in situ10.6
11hiv-110.6
12bacterial vaginosis10.5
13cervix uteri carcinoma in situ10.4
14conjunctivitis10.4
15vaginal cancer10.4
16blindness10.4
17vulvar intraepithelial neoplasia10.4
18endotheliitis10.4
19steatocystoma multiplex10.4KRT10, KRT17
20palmoplantar keratosis10.4KRT17, KRT10
21epidermolysis bullosa simplex10.3KRT17, KRT10
22cervical adenocarcinoma10.3CDKN2A, NME1
23gestational trophoblastic neoplasm10.3NME1, TERC
24lung cancer10.3CDKN2A, VEGFC
25obesity10.3
26epidermodysplasia verruciformis10.3
27ovarian cyst10.3
28papillary adenocarcinoma10.3
29peritonitis10.3
30bowenoid papulosis10.3
31drug addiction10.3
32smooth muscle tumor10.3MKI67, NME1
33aplastic anemia10.2TERC
34bowen syndrome10.2KRT10, KRT17, MKI67
35endometrial carcinoma10.2NME1, CDKN2A
36pulmonary fibrosis, familial10.2TERT, TERC
37grade iii astrocytoma10.2CDKN2A, ODC1, MKI67
38dyskeratosis congenita autosomal dominant10.2TERC, TERT
39ependymoma10.2MKI67, TERC
40lichen planus10.2KRT10, GZMB
41follicular thyroid carcinoma10.2VEGFC, NME1
42tongue squamous cell carcinoma10.2NME1, ODC1, MKI67
43bladder transitional cell carcinoma10.2MKI67, VEGFC
44dyskeratosis congenita10.2TERC, TERT
45gastritis10.1TERT, TERC
46peripheral t-cell lymphoma10.1GZMB, NME1
47seminoma10.1NME1, VEGFC, TERC
48uveal melanoma10.1CDKN2A, NME1, VEGFC
49esophageal cancer10.1VEGFC, NME1, CDKN2A
50barrett's esophagus10.1CDKN2A, ODC1, MKI67, TERC

Graphical network of the top 20 diseases related to Cervical Intraepithelial Neoplasia:



Diseases related to cervical intraepithelial neoplasia

Symptoms for Cervical Intraepithelial Neoplasia

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Drugs & Therapeutics for Cervical Intraepithelial Neoplasia

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Drug clinical trials:

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Search NIH Clinical Center for Cervical Intraepithelial Neoplasia

Genetic Tests for Cervical Intraepithelial Neoplasia

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Anatomical Context for Cervical Intraepithelial Neoplasia

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MalaCards organs/tissues related to Cervical Intraepithelial Neoplasia:

32
Cervix, Testes, T cells, Endothelial, Monocytes

Animal Models for Cervical Intraepithelial Neoplasia or affiliated genes

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MGI Mouse Phenotypes related to Cervical Intraepithelial Neoplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5TERC, YY1, NME1, KRT17, KRT10, CDKN2A
2MP:00053808.2TERC, CFLAR, ODC1, YY1, NME1, CDKN2A
3MP:00020068.1TERT, TERC, NME1, GZMB, KRT10, CDKN2A
4MP:00053977.8CDKN2A, GZMB, NME1, CFLAR, TERC, TERT
5MP:00053787.2TERT, TERC, CFLAR, YY1, NME1, KRT10
6MP:00053877.1TERT, TERC, CFLAR, VEGFC, GZMB, KRT10
7MP:00053847.1TERT, TERC, CFLAR, ODC1, YY1, GZMB
8MP:00053766.8TERT, TERC, CFLAR, VEGFC, YY1, NME1
9MP:00107685.6CDKN2A, TERT, TERC, CFLAR, VEGFC, ODC1

Publications for Cervical Intraepithelial Neoplasia

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Articles related to Cervical Intraepithelial Neoplasia:

(show top 50)    (show all 639)
idTitleAuthorsYear
1
Lineages of oncogenic human papillomavirus types other than type 16 and 18 and risk for cervical intraepithelial neoplasia. (25217779)
2014
2
Women whose cervical intraepithelial neoplasia has been treated or resolved remain at continued high risk for cervical cancer. (23378629)
2013
3
Stathmin-1 expression as a complement to p16 helps identify high-grade cervical intraepithelial neoplasia with increased specificity. (23211296)
2013
4
Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia across 5 countries in Asia. (23221730)
2013
5
Is vaccination with quadrivalent HPV vaccine after loop electrosurgical excision procedure effective in preventing recurrence in patients with high-grade cervical intraepithelial neoplasia (CIN2-3)? (23623831)
2013
6
Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study. (23095878)
2013
7
Use of the NucliSENS EasyQ HPV assay in the management of cervical intraepithelial neoplasia. (23918542)
2013
8
Results of pap smears and immunocytochemical detection of the p16 and Ki67 proteins in women with cervical intraepithelial neoplasia and cervical cancer]. (23379189)
2012
9
Overexpression of c-Met in cervical intraepithelial neoplasia. (23327059)
2012
10
Molecular mapping of high-grade cervical intraepithelial neoplasia shows etiological dominance of HPV16. (22419273)
2012
11
Inpatient and outpatient loop electrosurgery excision procedure for cervical intraepithelial neoplasia: a retrospective analysis. (22116315)
2012
12
Genomic amplification of hTERC in paraffin-embedded tissues of cervical intraepithelial neoplasia and invasive cancer. (22498947)
2012
13
Number of fragments, margin status and thermal artifacts of conized specimens from LLETZ surgery to treat cervical intraepithelial neoplasia. (22481754)
2012
14
The role of mRNA E6/E7 HPV high oncogenic risk expression in colposcopy of cervical intraepithelial neoplasia (CIN). (23401983)
2012
15
Factors affecting the clearance of high-risk human papillomavirus infection and the progression of cervical intraepithelial neoplasia. (22613409)
2012
16
Quality of life among Thai women diagnosed with cervical cancer and cervical intraepithelial neoplasia at King Chulalongkorn Memorial Hospital. (21863670)
2011
17
Cytokine serum levels in patients with cervical intraepithelial neoplasia grade II-III treated with intralesional interferon-I+ 2b. (22158487)
2011
18
Twelve-month follow-up detection of high-risk human papillomavirus (HPV) DNA for 93 cases with cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3) after a loop electrosurgical excisional procedure (LEEP). (21614905)
2011
19
IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer. (21997684)
2011
20
Increased serum progesterone and estradiol correlate to increased COX-2 tissue expression in cervical intraepithelial neoplasia. (20530431)
2010
21
Prospective study of the association of serum gamma-glutamyltransferase with cervical intraepithelial neoplasia III and invasive cervical cancer. (20388786)
2010
22
Endocervicoscopy: a new technique for the diagnostic work-up of cervical intraepithelial neoplasia allowing a tailored excisional therapy in young fertile women. (20451182)
2010
23
p16INK4a and low-grade cervical intraepithelial neoplasia. Diagnostic and therapeutic implications. (20882883)
2010
24
Use of various contraceptives and human papillomavirus 16 and 18 infections in women with cervical intraepithelial neoplasia. (20606223)
2010
25
Incidence and costs of cervical intraepithelial neoplasia in a US commercially insured population. (20040833)
2010
26
Cervical intraepithelial neoplasia recurrence after conization in HIV-positive and HIV-negative women. (19062013)
2009
27
Plasma proteome analysis of cervical intraepithelial neoplasia and cervical squamous cell carcinoma. (20093745)
2009
28
Epithelial and stromal metabolite changes in the transition from cervical intraepithelial neoplasia to cervical cancer: an in vivo 1H magnetic resonance spectroscopic imaging study with ex vivo correlation. (19259678)
2009
29
IFNG (+874 T/A) polymorphism and cervical intraepithelial neoplasia in Brazilian women. (19232001)
2009
30
Recurrent rates with cervical intraepithelial neoplasia having a negative surgical margin after the loop electrosurgical excision procedure in Thailand. (19827874)
2009
31
The diagnostic accuracy of colposcopy in previously treated cervical intraepithelial neoplasia. (19098599)
2009
32
Medical treatment of cervical intraepithelial neoplasia II, III: an update review. (19225922)
2009
33
Follow-up after treatment of cervical intraepithelial neoplasia by human papillomavirus genotyping. (19344881)
2009
34
Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. (18482945)
2008
35
The utility of p16(Ink4a) in discriminating between cervical intraepithelial neoplasia 1 and nonneoplastic equivocal lesions of the cervix. (18466028)
2008
36
Neutralizing antibodies against human papillomavirus types 16, 18, 31, 52, and 58 in serum samples from women in Japan with low-grade cervical intraepithelial neoplasia. (18753335)
2008
37
Effectiveness, safety, and acceptability of cryotherapy by midwives for cervical intraepithelial neoplasia in Maharashtra, India. (18817909)
2008
38
Frequency of cervical intraepithelial neoplasia and infectious agents for vaginitis in menstrual cycle phase. (17966219)
2007
39
Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status. (17303386)
2007
40
Glutathione-S-transferase M1 and T1 and cytochrome P1A1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women. (18090121)
2007
41
The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix. (17581402)
2007
42
Increased apoptosis in cervical intraepithelial neoplasia associated with HIV infection: implication of oncogenic human papillomavirus, caspases, and Langerhans cells. (15814619)
2005
43
Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer. (15923164)
2005
44
Misdiagnosis of high-grade vulvar intraepithelial neoplasia (VIN III) as mild cervical intraepithelial neoplasia (CIN I) on Papanicolaou tests. (12521370)
2003
45
Expression of the cell cycle regulator p27(Kip1) in normal squamous epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma of the uterine cervix. Immunohistochemistry and functional aspects of p27(Kip1). (11753978)
2001
46
Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia. (10928104)
2000
47
Increased carcinoembryonic antigen expression in cervical intraepithelial neoplasia grade 3 and in cervical squamous cell carcinoma. (11112209)
2000
48
Progressing imbalance between proliferation and apoptosis with increasing severity of cervical intraepithelial neoplasia. (9421084)
1997
49
An immunohistochemical study of p53 protein in cervical intraepithelial neoplasia and squamous cell carcinoma. (8714263)
1996
50
Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia. (1637668)
1992

Variations for Cervical Intraepithelial Neoplasia

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Expression for genes affiliated with Cervical Intraepithelial Neoplasia

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Expression patterns in normal tissues for genes affiliated with Cervical Intraepithelial Neoplasia

Search GEO for disease gene expression data for Cervical Intraepithelial Neoplasia.

Pathways for genes affiliated with Cervical Intraepithelial Neoplasia

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Pathways related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6NME1, GZMB
2
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.2CDKN2A, GZMB, CFLAR
3
Show member pathways
9.0CDKN2A, CDC6, YY1, MKI67
49.0GZMB, YY1, CFLAR
58.9TERT, ODC1, NME1
6
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.9CFLAR, ODC1, GZMB, CDC6
7
Show member pathways
8.3CDKN2A, VEGFC, CFLAR, TERT

Compounds for genes affiliated with Cervical Intraepithelial Neoplasia

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Compounds related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1hematoxylin449.8MKI67, KRT10, CDKN2A
2isotretinoin44 1110.8MKI67, ODC1, KRT10
3dutp449.6MKI67, CFLAR, KRT10
4biotin44 24 1111.6CDKN2A, NME1, MKI67
5lipofectamine449.6TERC, TERT
6irinotecan44 50 1111.6MKI67, CFLAR, CDKN2A
7p00001449.5CDKN2A, VEGFC, MKI67
8agar449.5CDKN2A, NME1, ODC1, TERC
9p002449.4MKI67, CFLAR, NME1
10vincristine44 50 1111.3MKI67, CFLAR, ODC1, CDKN2A
11depsipeptide449.2CDKN2A, CFLAR, TERT
12fatty acid449.2CDKN2A, KRT10, NME1, MKI67
13glyceraldehyde 3-phosphate449.2KRT10, NME1, ODC1, VEGFC
14tin(2+)449.1TERT, TERC
15adpribose449.1TERT, TERC, YY1
16egcg449.0CDKN2A, ODC1, TERT
17thymidylate449.0CDKN2A, ODC1, MKI67, TERT
18lactate448.8MKI67, ODC1, NME1, GZMB
19camptothecin44 61 1110.8CDKN2A, CFLAR, TERT
20adriamycin448.7TERT, TERC, CFLAR, ODC1, CDKN2A
21dexamethasone44 50 28 1111.7CDKN2A, KRT10, GZMB, NME1, VEGFC
22progesterone44 28 61 24 1112.7TERC, MKI67, VEGFC, NME1, KRT10, CDKN2A
23butyrate448.6TERT, TERC, ODC1, YY1, CDKN2A
24rapamycin448.6TERT, CFLAR, ODC1, GZMB
25atp44 289.6YY1, NME1, GZMB, KRT17, CDC6, CDKN2A
26paclitaxel44 50 1110.5TERT, MKI67, CFLAR, ODC1, CDKN2A
27steroid448.5MKI67, YY1, NME1, GZMB, KRT10, CDKN2A
28threonine448.4CDKN2A, KRT10, CFLAR, MKI67, TERT
295fluorouracil448.3TERT, TERC, MKI67, CFLAR, NME1, CDKN2A
30ly294002448.3GZMB, VEGFC, CFLAR, TERT
31doxorubicin44 50 1110.3TERT, TERC, MKI67, CFLAR, ODC1, CDKN2A
32etoposide44 50 61 1111.2TERT, TERC, CFLAR, NME1, GZMB, CDC6
33ribonucleic acid448.2TERT, VEGFC, ODC1, NME1, GZMB
34arginine448.1CDKN2A, KRT10, GZMB, ODC1, MKI67, TERT
35cysteine448.0TERT, CFLAR, ODC1, NME1, GZMB, CDKN2A
36glucose448.0MKI67, CFLAR, VEGFC, YY1, GZMB, CDKN2A
37testosterone44 61 24 1110.9TERT, MKI67, CFLAR, VEGFC, ODC1, CDKN2A
38oxygen44 248.7TERT, MKI67, CFLAR, VEGFC, GZMB, CDKN2A
39lipid447.5TERT, TERC, MKI67, CFLAR, VEGFC, GZMB
40vegf447.4TERT, MKI67, CFLAR, VEGFC, NME1, GZMB
41cisplatin44 50 61 1110.3TERT, TERC, MKI67, CFLAR, YY1, NME1
42thymidine44 248.1TERT, TERC, MKI67, CFLAR, VEGFC, ODC1
43serine447.1TERT, MKI67, CFLAR, ODC1, NME1, GZMB
44tyrosine446.7TERT, MKI67, CFLAR, VEGFC, ODC1, NME1
45paraffin446.7KRT10, KRT17, GZMB, NME1, ODC1, VEGFC
46calcium44 50 24 119.6TERT, MKI67, CFLAR, VEGFC, YY1, NME1
47nitric oxide44 24 118.6TERT, MKI67, CFLAR, VEGFC, ODC1, YY1
48oligonucleotide446.5TERT, TERC, CFLAR, VEGFC, YY1, NME1
49estrogen446.5VEGFC, MKI67, TERC, TERT, ODC1, YY1
50retinoic acid44 247.2CDKN2A, TERT, KRT10, KRT17, GZMB, NME1

GO Terms for genes affiliated with Cervical Intraepithelial Neoplasia

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Cellular components related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.2ODC1, NME1, GZMB, CDC6, CDKN2A, CFLAR
2cytoplasmGO:0057376.4CDKN2A, TERT, MKI67, CFLAR, NME1, GZMB

Biological processes related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.4CDKN2A, TERT

Molecular functions related to Cervical Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.9CDKN2A, MKI67, CFLAR, VEGFC, YY1, NME1

Products for genes affiliated with Cervical Intraepithelial Neoplasia

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Sources for Cervical Intraepithelial Neoplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet