MCID: CRV038
MIFTS: 49

Cervical Squamous Cell Carcinoma malady

Cancer diseases category

Summaries for Cervical Squamous Cell Carcinoma

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34MalaCards
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MalaCards: Cervical Squamous Cell Carcinoma, also known as squamous cell carcinoma of the cervix uteri, is related to cervical intraepithelial neoplasia and cervical adenocarcinoma. An important gene associated with Cervical Squamous Cell Carcinoma is SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Matrix Metalloproteinases. The compounds calcipotriol and ethylenediaminetetraacetic acid have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and ovary, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Aliases & Classifications for Cervical Squamous Cell Carcinoma

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical squamous cell carcinoma 9 11 46 63
squamous cell carcinoma of the cervix uteri 9
squamous cell carcinoma of cervix 9


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Disease Ontology9 DOID:3744
SNOMED-CT59 254886006
NCIt41 C4028

Related Diseases for Cervical Squamous Cell Carcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Cervical Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia30.8TP73, KRT8, KRT10
2cervical adenocarcinoma30.4KRT8, RASSF1
3adenocarcinoma30.4DAPK1, TYMP, KRT14, KRT10, KRT8, RASSF1
4papilloma30.2TP73, RASSF1, KRT10, KRT14
5cervicitis11.4
6microinvasive cervical squamous cell carcinoma10.5
7cardiac tamponade10.4
8neuroendocrine carcinoma10.4
9small cell neuroendocrine carcinoma10.4
10endometrial adenocarcinoma10.4
11keratoacanthoma10.4
12keratinizing squamous cell carcinoma10.3
13fibrous histiocytoma10.3
14anal squamous cell carcinoma10.3
15histiocytoma10.3
16sarcoma10.3
17endocervicitis10.2
18breast adenocarcinoma10.2
19cervical carcinosarcoma10.2
20dermatomyositis10.2
21vaginitis10.2
22neuroendocrine carcinoma of the cervix10.2
23rare squamous cell carcinoma of the cervix uteri10.2
24serous cystadenocarcinoma10.1TYMP, MMP14
25bowen syndrome10.1KRT14, KRT10
26epidermolysis bullosa simplex10.1KRT10, KRT14
27nonepidermolytic palmoplantar keratoderma10.1KRT10, KRT14
28pancreatic ductal carcinoma10.1KRT8, TYMP
29laryngeal benign neoplasm10.1SERPINB3, MMP14
30cholesteatoma10.1KRT14, KRT10
31adenosquamous carcinoma10.1KRT8, TYMP
32craniopharyngioma10.1KRT8, KRT14
33chordoma10.0KRT14, KRT8
34angiosarcoma10.0KRT8, KRT14
35adenoameloblastoma10.0KRT14, KRT8
36skin disease10.0KRT10, KRT14, CD40
37bladder carcinoma in situ10.0RASSF1, SERPINB3
38abdominal aortic aneurysm10.0TIMP2, MMP14
39plasma cell leukemia10.0TP73, CD40
40keloids10.0KRT14, TIMP2
41psoriasis10.0SERPINB3, KRT10, KRT14, CD40
42endometriosis10.0TYMP, TIMP2, MMP14
43kidney rhabdoid cancer10.0RASSF1, TYMP
44gallbladder cancer10.0KRT8, TIMP2, TYMP
45oxyphilic adenoma10.0RASSF1, KRT8, KRT14
46synovial sarcoma10.0KRT14, KRT8, RASSF1
47hepatitis b10.0TYMP, SERPINB3, MMP14, KRT8
48familial adenomatous polyposis10.0DAPK1, MMP14, RASSF1
49hepatitis10.0KRT8, TIMP2
50cholangiocarcinoma10.0KRT8, RASSF1, DAPK1

Graphical network of the top 20 diseases related to Cervical Squamous Cell Carcinoma:



Diseases related to cervical squamous cell carcinoma

Symptoms for Cervical Squamous Cell Carcinoma

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Drugs & Therapeutics for Cervical Squamous Cell Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Cervical Squamous Cell Carcinoma

Search NIH Clinical Center for Cervical Squamous Cell Carcinoma

Search CenterWatch for Cervical Squamous Cell Carcinoma

Genetic Tests for Cervical Squamous Cell Carcinoma

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Anatomical Context for Cervical Squamous Cell Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Cervical Squamous Cell Carcinoma:

34
Cervix, Lymph node, Ovary, Placenta, Testes, Lung, Breast, Skin, Testis

Animal Models for Cervical Squamous Cell Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Cervical Squamous Cell Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.7TP73, MMP14, KRT10, KRT14
2MP:00053828.6KRT14, KRT10, MMP14, TP73
3MP:00020068.1TP73, RASSF1, KRT10, KRT14
4MP:00053977.5TP73, TIMP2, MMP14, KRT8, KRT14, CD40
5MP:00053847.5DAPK1, TYMP, TP73, MMP14, RASSF1, KRT14
6MP:00036317.4DAPK1, TYMP, TP73, TIMP2, MMP14, CD40
7MP:00053766.7DAPK1, TYMP, TP73, TIMP2, MMP14, RASSF1
8MP:00053876.5CD40, TYMP, TP73, TIMP2, MMP14, RASSF1

Publications for Cervical Squamous Cell Carcinoma

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53PubMed
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Articles related to Cervical Squamous Cell Carcinoma:

(show top 50)    (show all 216)
idTitleAuthorsYear
1
Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery. (24405714)
2014
2
Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics. (24385692)
2013
3
Case of metastatic uterine cervical squamous cell carcinoma in the right atrium. (23564576)
2013
4
Primary Squamous Cell Carcinoma of the Upper Genital Tract: Utility of p16(INK4a) Expression and HPV DNA Status in its Differential Diagnosis from Extended Cervical Squamous Cell Carcinoma. (24421848)
2013
5
Genetic variants in interleukin-18 gene and risk for cervical squamous cell carcinoma. (23603311)
2013
6
ERCC1 mRNA levels can predict the response to cisplatin-based concurrent chemoradiotherapy of locally advanced cervical squamous cell carcinoma. (23259415)
2012
7
Screening test results associated with cancer diagnoses in 287 women with cervical squamous cell carcinoma. (22900617)
2012
8
Recurrence during pregnancy of a conservatively treated early-stage cervical squamous cell carcinoma. (20655526)
2011
9
Laparoscopic adrenalectomy for isolated adrenal metastasis from cervical squamous cell carcinoma and endometrial adenocarcinoma. (21664660)
2011
10
Two novel unbalanced whole arm translocations are frequently detected in cervical squamous cell carcinoma. (22285016)
2011
11
Reduced expression of I9I9p63I+ inA cervical squamous cell carcinoma. (21631996)
2011
12
Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma. (21319225)
2011
13
Expression of macrophage migration inhibitory factor and CD74 in cervical squamous cell carcinoma. (21792010)
2011
14
Influence of lymph vascular space invasion on prognosis of patients with early-stage cervical squamous cell carcinoma. (20346220)
2010
15
Expression of PSCA, PIWIL1 and TBX2 and its correlation with HPV16 infection in formalin-fixed, paraffin-embedded cervical squamous cell carcinoma specimens. (20229117)
2010
16
Significant effects of lymph and blood vascular invasion on the prognosis of early-stage cervical squamous cell carcinoma. (20846259)
2010
17
Plasma proteome analysis of cervical intraepithelial neoplasia and cervical squamous cell carcinoma. (20093745)
2009
18
Cyclooxygenase-2 expression in cervical squamous cell carcinoma: the significance of expression in neoplastic cells within the lymphovascular space. (20192574)
2009
19
Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma. (19638983)
2009
20
Microarray profile of micro-ribonucleic acid in tumor tissue from cervical squamous cell carcinoma without human papillomavirus. (20149030)
2009
21
Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy. (19030960)
2008
22
Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. (17503414)
2007
23
Early determination of uterine cervical squamous cell carcinoma radioresponse identifies high- and low-response tumors. (16343805)
2006
24
Expression and clinical significance of autophagy gene Beclin 1 in cervical squamous cell carcinoma]. (17236580)
2006
25
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. (16425263)
2006
26
HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and meta-analysis. (16720214)
2006
27
Tumor lymphangiogenesis in cervical squamous cell carcinoma and its clinical significance]. (16179117)
2005
28
Cell proliferation of bulky cervical squamous cell carcinoma is strongly associated with a paracrine tissue-specific growth factor(s). (16211274)
2005
29
Expression of metastasis suppressor gene KAI1/CD82 in cervical squamous cell carcinoma and its clinical significance]. (15642213)
2005
30
P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma. (14599865)
2003
31
Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma. (12798701)
2003
32
Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia. (12100520)
2002
33
Chlamydia trachomatis and cervical squamous cell carcinoma. (11277820)
2001
34
Karyometric features differentiate early invasive cervical squamous cell carcinoma from preinvasive carcinoma. (11915180)
2001
35
Increased carcinoembryonic antigen expression in cervical intraepithelial neoplasia grade 3 and in cervical squamous cell carcinoma. (11112209)
2000
36
Relative changes of MIB1 and PC10 labeling indexes in cell kinetics during radiotherapy for cervical squamous cell carcinoma. (9490095)
1997
37
Possible involvement of tumour-derived interleukin-6 in dermatomyositis associated with cervical squamous cell carcinoma. (9115948)
1997
38
Expression of retinoic acid receptor-beta 2 mRNA in normal cervical epithelium and cervical squamous cell carcinoma. (21528293)
1997
39
Cervical squamous cell carcinoma and its precursor lesions: cytodiagnostic criteria and pitfalls. (9390926)
1996
40
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study. (8697388)
1996
41
Angiogenesis in uterine cervical squamous cell carcinoma. (8601522)
1995
42
Age is prognostic variable in cervical squamous cell carcinoma. (8344321)
1993
43
Intrinsic resistance of cervical squamous cell carcinoma cell lines to methotrexate (MTX) as a result of decreased accumulation of intracellular MTX polyglutamates. (7694891)
1993
44
Expression of ras oncogene product and EGF receptor in cervical squamous cell carcinomas and its relationship to lymph node involvement. (1707025)
1991
45
Keratoacanthomas associated with cervical squamous cell carcinoma. (4004294)
1985
46
Tumor-antigen TA-4 in the detection of recurrence in cervical squamous cell carcinoma. (6478396)
1984
47
Keratoacanthomas associated with cervical squamous cell carcinoma. (6691710)
1984
48
Tumor antigen of human cervical squamous cell carcinoma: correlation of circulating levels with disease progress. (421183)
1979
49
Biological properties and radiation responses of the hamster uterine cervical squamous cell carcinoma. (441259)
1979
50
Decidual change in pelvic lymph nodes in the presence of cervical squamous cell carcinoma during pregnancy. (842598)
1977

Variations for Cervical Squamous Cell Carcinoma

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Expression for genes affiliated with Cervical Squamous Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Squamous Cell Carcinoma.

Pathways for genes affiliated with Cervical Squamous Cell Carcinoma

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 31KEGG
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Pathways related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6KRT14, KRT8
2
Show member pathways
9.5MMP14, TIMP2
3
Show member pathways
Signaling Pathways in Glioblastoma39
9.1RASSF1, TYMP, DAPK1

Compounds for genes affiliated with Cervical Squamous Cell Carcinoma

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1calcipotriol46 62 30 1212.9KRT14, KRT10
2ethylenediaminetetraacetic acid469.7MMP14, TIMP2
3cytochalasin469.7MMP14, TIMP2
4hematoxylin469.7KRT8, KRT10, KRT14
5sodium bisulfite469.6RASSF1, DAPK1
65-methylcytosine46 2510.6RASSF1, DAPK1
7p00001469.6MMP14, TIMP2, TYMP
8cytosine46 2510.5KRT14, RASSF1, TYMP
9crcs469.5DAPK1, TYMP, RASSF1
10herbimycin a46 6210.4TIMP2, MMP14, CD40
11bromodeoxyuridine469.4KRT14, KRT10, KRT8, MMP14
12retinoid469.3KRT14, KRT10, KRT8
13glyceraldehyde 3-phosphate469.2TYMP, TIMP2, MMP14, KRT10
14methotrexate52 46 1211.2CD40, TIMP2, TYMP
1512-o-tetradecanoylphorbol 13-acetate469.2CD40, MMP14, TIMP2, TYMP
16ly294002469.1TYMP, TIMP2, MMP14, CD40
17thymidine46 2510.1CD40, MMP14, TIMP2, TYMP
18matrigel469.1TYMP, TIMP2, MMP14, KRT8
19paclitaxel46 52 1211.1CD40, KRT8, TIMP2, TYMP
20o6-methylguanine469.0DAPK1, TP73, RASSF1
21tamoxifen46 52 30 1212.0KRT14, KRT8, TIMP2, TYMP
22creatinine469.0TYMP, TIMP2, KRT8, CD40
23butyrate469.0TIMP2, KRT8, KRT14, CD40
24genistein46 30 62 3 25 1214.0TIMP2, MMP14, KRT8, CD40
25chloramphenicol46 3 52 1211.9CD40, KRT14, MMP14, TP73
26cholesterol46 30 25 1211.9TIMP2, MMP14, KRT14, CD40
27doxorubicin46 52 1210.9CD40, KRT8, TP73, TYMP
28agar468.8KRT8, RASSF1, MMP14
29steroid468.8TIMP2, KRT8, KRT10, CD40
30azathioprine46 3 52 1211.8TP73, TIMP2, RASSF1
31p002468.8TYMP, TP73, TIMP2, MMP14
32cycloheximide468.7CD40, KRT8, MMP14, TIMP2, TYMP
335fluorouracil468.6TYMP, TP73, TIMP2
345-aza-2deoxycytidine468.4DAPK1, TP73, TIMP2, RASSF1
35cisplatin46 52 62 1211.4KRT14, KRT8, RASSF1, TP73, TYMP
36glucose468.4TYMP, TIMP2, MMP14, KRT8, KRT14, CD40
37p003468.3TYMP, TP73, TIMP2, RASSF1, CD40
38cysteine468.1TYMP, TIMP2, SERPINB3, MMP14, KRT8, KRT14
39actinomycin d468.0TYMP, TP73, TIMP2, MMP14, KRT8, CD40
40vegf468.0TYMP, TP73, TIMP2, MMP14, KRT8, CD40
41lipid467.8TP73, TIMP2, MMP14, KRT8, KRT14, CD40
42calcium46 52 25 1210.8DAPK1, TIMP2, MMP14, KRT8, KRT10, KRT14
43oligonucleotide467.8TP73, TIMP2, MMP14, RASSF1, KRT8, CD40
44paraffin467.3CD40, TYMP, TP73, TIMP2, MMP14, KRT8
45progesterone46 30 62 25 1211.3TYMP, TP73, TIMP2, MMP14, KRT8, KRT10
46tyrosine467.3TYMP, TP73, TIMP2, MMP14, KRT8, KRT10
47threonine467.2DAPK1, TP73, MMP14, RASSF1, KRT8, KRT10
48retinoic acid46 257.9DAPK1, TP73, TIMP2, RASSF1, KRT8, KRT10
49serine466.8DAPK1, TYMP, TIMP2, SERPINB3, MMP14, RASSF1
50estrogen466.6DAPK1, TYMP, TP73, TIMP2, MMP14, RASSF1

GO Terms for genes affiliated with Cervical Squamous Cell Carcinoma

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17Gene Ontology
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Cellular components related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.3KRT14, KRT10, KRT8
2intermediate filamentGO:0058829.2KRT8, KRT10, KRT14
3extracellular spaceGO:0056158.9CD40, KRT10, SERPINB3, TIMP2
4extracellular vesicular exosomeGO:0700628.4SERPINB3, KRT8, KRT10, KRT14, CD40
5cytoplasmGO:0057377.3CD40, DAPK1, SERPINB3, MMP14, RASSF1, KRT8

Biological processes related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of proteolysisGO:0458619.6SERPINB3, TIMP2

Molecular functions related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4CD40, KRT14, KRT8, RASSF1, MMP14, TIMP2

Products for genes affiliated with Cervical Squamous Cell Carcinoma

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  • Antibodies
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Sources for Cervical Squamous Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet