Cervical Squamous Cell Carcinoma malady

MalaCards: Cervical Squamous Cell Carcinoma, also known as squamous cell carcinoma of cervix (disorder), is related to squamous cell carcinoma and cervical cancer. An important gene associated with Cervical Squamous Cell Carcinoma is SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3), and among its related pathways are Colorectal cancer and Non-small cell lung cancer. The drugs bleomycin sulfate and bleomycin and the compounds threonine and glucose have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and testis, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

cervical squamous cell carcinoma 6 8 32 43 squamous cell carcinoma of cervix (disorder) 6

squamous cell carcinoma of the cervix uteri 6 squamous cell carcinoma 43

Diseases related to cervical squamous cell carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 769)

id	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	37.8	SERPINB3, SERPINB4, MMP7, MKI67, CCNA2, TP73
2	cervical cancer	36.0	TP63, SKP2, KRT14
3	basaloid squamous cell carcinoma	34.8	MYC, BIRC5, BAX, CEACAM7, CDKN1B, CDKN2A
4	keratoacanthoma	34.6	BCL2, MUC1, CDKN1A, IVL, MMP7, MLH1
5	basal cell carcinoma	34.2	BCL2, BAX, IVL, MKI67, FASLG, TP53
6	maxillary sinus squamous cell carcinoma	33.5	BAX, CDKN1A, TP53
7	squamous cell carcinoma of the head and neck	33.0	MYC, RASSF1, BIRC5, BCL2, CDKN1A, CDKN2A
8	actinic keratosis	32.9	MYC, BCL2, CEACAM5, CDKN1B, CDKN2A, MMP2
9	cystic teratoma	32.7	CDKN2A, TP53, PTGS2, KRT10
10	epidermolysis bullosa	32.5	MUC1, CDKN2A, IVL, HLA-DRB1, TP53, KRT10
11	adenoid cystic carcinoma	32.3	RASSF1, MUC1, MKI67, TP63, DAPK1, KRT8
12	teratoma	32.1	BCL2, BAX, CDKN2A, TP53, PTGS2, PDPN
13	keratosis	32.0	MYC, BCL2, CEACAM5, CDKN1A, CDKN1B, CDKN2A
14	tongue cancer	32.0	CDKN1A, MMP2, MMP9
15	leukoplakia	31.7	BCL2, BAX, CDKN1B, CDKN2A, IVL, MMP2
16	verrucous carcinoma	31.6	CDKN1A, CDKN2A, IFNA1, TP53, KRT10, EGFR
17	laryngeal squamous cell carcinoma	31.6	BSG, MYC, BIRC5, BCL2, BAX, CDKN1A
18	oral squamous cell carcinoma	31.5	SERPINB3, SERPINB4, BSG, MYC, BIRC5, BCL2
19	xeroderma pigmentosum	31.5	BCL2, BAX, CDKN2A, FAS, HMGB1, TP53
20	hidradenitis	31.5	MUC1, KRT8, KRT10, KRT14
21	adenosquamous carcinoma	31.3	MUC1, CEACAM5, CEACAM7, IVL, FHIT, TP63
22	lichen sclerosus	31.2	CDKN2A, IVL, FAS, HLA-DQB1, HLA-DRB1, TP53
23	dna topoisomerase ii	31.1	MYC, CDKN1A, MKI67, TP53, PTGS2
24	actinic cheilitis	30.7	BAX, CDKN1A, MMP9, MKI67, TP53, PTGS2
25	inverted papilloma	30.7	SERPINB3, BCL2, CDKN1A, CDKN1B, CDKN2A, MMP2
26	esophageal squamous cell carcinoma	30.7	SERPINB3, BSG, MYC, RASSF1, BIRC5, BECN1
27	hepatitis b	30.6	CD40, IFNA1, HLA-DQB1, HLA-DRB1, CTLA4, TGFB1
28	basaloid squamous cell skin carcinoma	30.5	IFNA1, TP53, TP63, EGF
29	cheilitis	30.3	BAX, CDKN1A, MMP9, MKI67, TP53, PTGS2
30	laryngitis	30.1	SERPINB3, BSG, MYC, RASSF1, BIRC5, BCL2
31	hepatitis	30.1	FASLG, FAS, IFNA1, HLA-A, HLA-DRB1, KRT8
32	trichoepithelioma	30.1	BCL2, IVL, MKI67, PDPN, KRT8, KRT10
33	neuroendocrine carcinoma	30.0	MUC1, CEACAM5, MMP7, FHIT, TP63, KRT8
34	anaplastic carcinoma	30.0	MUC1, FHIT, TP63, KRT8
35	bullous pemphigoid	29.9	CD40, IVL, HLA-DQA1, HLA-DQB1, HLA-DRB1, KRT14
36	skin melanoma	29.9	CDKN1A, CDKN2A, MMP2, MLH1, MKI67, TP53
37	lung occult squamous cell carcinoma	29.8	BCL2, CDKN1A, MKI67, FAS, HLA-DQA1, TP53
38	tonsillitis	29.6	BCL2, MUC1, CDKN1B, CDKN2A, CD40, FASLG
39	small cell carcinoma	29.6	RASSF1, BCL2, MUC1, BAX, CEACAM5, CDKN1B
40	superficial basal cell carcinoma	29.6	BCL2, JAG1, IFNA1
41	malignant pleural mesothelioma	29.5	BIRC5, MUC1, CEACAM5, CEACAM7, PDPN, TYMS
42	papilloma	29.4	SERPINB3, RASSF1, BIRC5, BCL2, MUC1, BAX
43	benign tumors	29.4	BSG, RASSF1, MUC1, MMP14, MKI67, TP73
44	large cell carcinoma	29.3	BCL2, BAX, TP53, TP63, EGFR
45	gastric cardia adenocarcinoma	29.2	MYC, RASSF1, MMP2, PTGS2, TGFB1, HLTF
46	papillary thyroid carcinoma	29.1	RAP1A, RASSF1, BAX, MMP7, TP63, STAT3
47	esophagitis	29.0	SERPINB3, SERPINB4, BSG, MYC, RASSF1, BIRC5
48	mucoepidermoid carcinoma	28.9	MUC1, CEACAM5, CDKN1B, IVL, MKI67, TP63
49	esophagus adenocarcinoma	28.9	BCL2, CDKN1A, CDKN2A, MKI67, TP53, PTGS2
50	merkel cell carcinoma	28.8	RASSF1, BIRC5, BCL2, MUC1, BAX, CDKN1A

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bleomycin, bleomycin sulfate

MalaCards organs/tissues related to cervical squamous cell carcinoma:

²²

MGI Mouse Phenotypes related to cervical squamous cell carcinoma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.8	TP63
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	KRAS, CTLA4, DDR1, TP63, FASLG, GRB10
3	craniofacial phenotype	MP:0005382	9.8	KRT10, DDR1, TP73, IGF1R, JAG1
4	reproductive system phenotype	MP:0005389	9.1	SKP2, KRT8, KRAS, KRT14, TIMP3, TGFB1
5	hematopoietic system phenotype	MP:0005397	9.0	CXCL14, OSMR, ST6GAL1, KRAS, KRT8, SKP2
6	renal/urinary system phenotype	MP:0005367	9.0	DDR1, DAPK1, SKP2, KRAS, EGFR, HIF1A
7	embryogenesis phenotype	MP:0005380	9.0	TP73, KRT8, KRAS, EGFR, DVL1, TP63
8	liver/biliary system phenotype	MP:0005370	8.7	CXCL14, HIF1A, ACADVL, EGFR, CTLA4, TP53
9	normal phenotype	MP:0002873	8.6	CTLA4, KRAS, HIF1A, DVL1, STAT3, ST6GAL1
10	behavior/neurological phenotype	MP:0005386	8.1	CTSD, NFKB1, PDPN, ACADVL, TIMP2, TIMP3
11	limbs/digits/tail phenotype	MP:0005371	8.0	KRT10, KRAS, EGFR, STAT1, TP63, HOXC10
12	hearing/vestibular/ear phenotype	MP:0005377	7.7	TP73, DDR1, NFKB1, KRT10, EGFR, DVL1
13	pigmentation phenotype	MP:0001186	7.7	TIMP3, EGFR, KRT14, KRAS, CTLA4, TP53
14	mortality/aging	MP:0010768	7.7	GRB10, FHIT, MMP14, CDKN1B, CDKN1A, JAG1
15	adipose tissue phenotype	MP:0005375	7.1	PTGS2, EGFR, ACADVL, TGFB1, STAT3, TP53
16	digestive/alimentary phenotype	MP:0005381	7.1	STAT1, ST6GAL1, TGFB1, HIF1A, EGFR, EGF
17	immune system phenotype	MP:0005387	7.0	DDR1, TEC, TP63, TP53, HLA-DQB1, HLA-DQA1
18	nervous system phenotype	MP:0003631	7.0	CTSD, KRAS, EGFR, HIF1A, TYMP, TIMP2
19	integument phenotype	MP:0010771	6.9	EGFR, MUC1, BCL2, BECN1, MYC, CEBPB
20	vision/eye phenotype	MP:0005391	5.5	TP73, TP63, TP53, HMGB1, FAS, FASLG
21	growth/size phenotype	MP:0005378	5.4	KRT10, KRT8, SKP2, PDPN, NFKB1, DDR1
22	skeleton phenotype	MP:0005390	5.2	TP63, TP73, PTGS2, DDR1, CTLA4, NFKB1
23	tumorigenesis	MP:0002006	5.1	FASLG, FHIT, MLH1, MMP9, MMP7, MMP2
24	muscle phenotype	MP:0005369	4.9	IGF1R, GRB10, MMP9, MMP2, MMP14, CDKN2A
25	cardiovascular system phenotype	MP:0005385	4.4	KRT8, PDPN, CTLA4, DDR1, PTGS2, TP73
26	cellular phenotype	MP:0005384	3.2	SKP2, NFKB1, CTLA4, CTSD, DAPK1, DDR1
27	homeostasis/metabolism phenotype	MP:0005376	2.7	KRAS, FASLG, GRB10, FHIT, MLH1, MMP9

Articles related to cervical squamous cell carcinoma:

(show top 50)    (show all 55)

id	Title	Authors	Year	Affiliating Genes
1	HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women. (20501960)	Hosono S.... Tanaka H.	2010	HLA-A
2	Influence of CTLA-4/CD28/ICOS gene polymorphisms on t he susceptibility to cervical squamous cell carcinoma and stage of differentiat ion in the Polish population. (19913589)	Pawlak E.... Frydecka I.	2010	CTLA4, CD28, ICOS
3	Differential gene expression identified in Uigur wome n cervical squamous cell carcinoma by suppression subtractive hybridization. (20099975)	Pan Z.... Shao R.	2010	ACADVL, CEBPB, IFITM1
4	Relationship between NFKB1 -94 insertion/deletion ATT G polymorphism and susceptibility of cervical squamous cell carcinoma risk. (19892748)	Zhou B.... Zhang L.	2010	NFKB1
5	Polymorphism of HLA-DRB1 and -DQB1 alleles among you ng women with cervical squamous cell carcinoma and its relation with human papi llomavirus type 16 infection]. (21029659)	Hu Y.... Shuai C.X.	2010	HLA-DQB1, HLA-DRB1
6	Plasma proteome analysis of cervical intraepithelial neoplasia and cervical squamous cell carcinoma. (20093745)	Looi M.L.... Yusof Y.A.	2009	CLEC3B
7	Cyclooxygenase-2 expression in cervical squamous cell carcinoma: the significance of expression in neoplastic cells within the lymph ovascular space. (20192574)	Settakorn J.... Siriaungkul S.	2009	PTGS2
8	Usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung. (19369633)	Wang C.W.... Chen T.C.	2009	CDKN2A
9	Methylation of the RASSF1A gene promoter in Uigur women with cervical squamous cell carcinoma. (19366060)	Pan Z.... Shao R.	2009	RASSF1
10	Gene expression changes in cervical squamous cell carcinoma after initiation of chemoradiation and correlation with clinical outcome. (18406887)	Klopp A.H.... Buchholz T.A.	2008	C19orf33
11	Expression of Skp2 in cervical squamous cell carcinoma and precancerous lesions and its correlation with HPV16/18 infection (19094580)	Pan B.J.... Chen J.W.	2008	SKP2
12	Expression and clinical significance of HMGB1 and RAGE in cervical squamous cell carcinoma (18788635)	Hao Q.... Tian J.	2008	HMGB1
13	Galectin-9 expression links to malignant potential of cervical squamous cell carcinoma. (18264727)	Liang M.... Hirashima M.	2008	LGALS9
14	Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. (17974957)	Zhai Y.... Cho K.R.	2007	HOXC10
15	Radiation reduces carboplatin sensitivity and enhance s nedaplatin sensitivity in cervical squamous cell carcinoma in vitro. (17966212)	Tanaka T.... Umesaki N.	2007	DDR1
16	Correlation between survivin expression and locoregio nal control in cervical squamous cell carcinomas treated with radiation therapy . (17141299)	Suzuki Y.... Nakano T.	2007	BIRC5
17	Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with adverse clinical outcome. (17516585)	Ng G.... Coleman N.	2007	STAT3, OSM, OSMR
18	CTLA-4 gene and susceptibility to human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese women. (17341658)	Su T.H.... Yang Y.C.	2007	CTLA4
19	Expression and clinical significance of autophagy gene Beclin 1 in cervical squamous cell carcinoma (17236580)	Wang Z.H.... Liu H.	2006	BECN1
20	EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. (16425263)	Sier C.F.... Gorter A.	2006	MMP2, MMP14, TIMP2
21	Expression of thymidine phosphorylase as an effect prediction factor for uterine cervical squamous cell carcinoma after radiotherapy: an immunohistochemical study. (16803522)	Nakashima M.... Kojima Y.	2006	TYMP
22	Inactivation of Crk SH3 domain-binding guanine nucleotide-releasing factor (C3G) in cervical squamous cell carcinoma. (16681758)	Okino K.... Takeshita T.	2006	RAP1A, RAPGEF1
23	Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma. (16331610)	Kang S.... Lee H.P.	2006	DAPK1, TIMP3, HLTF
24	Expression of ETV5 and MMP-7 in early stage cervical squamous cell carcinoma and its role in lymphatic metastasis (16536985)	Wu S.H.... Li J.M.	2006	MMP7
25	HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and meta-analysis. (16720214)	Yang Y.C.... Lin M.	2006	HLA-DRB1
26	Expression of deltaNp73 and TAp73alpha independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma. (16818688)	Liu S.S.... Ngan H.Y.	2006	TP73
27	Tumor lymphangiogenesis in cervical squamous cell carcinoma and its clinical significance (16179117)	Zhang J.P.... Xie X.	2005	PDPN
28	Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma. (15870923)	Okino K.... Takeshita T.	2005	IGF1R, TEC, GRB10
29	Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines. (16211231)	Sueoka K.... Sugino N.	2005	MMP9, SERPINB3, SERPINB4
30	Reduced radiosensitivity and increased CD40 expression in cyclophosphamide-resistant subclones established from human cervical squamous cell carcinoma cells. (16142355)	Tanaka T.... Umesaki N.	2005	CD40
31	Thymidine phosphorylase expression is preserved after radiotherapy in patients with cervical squamous cell carcinoma. (14614573)	Oguri H.... Fukaya T.	2004	DPYD, TYMP
32	Prognostic significance of Bax, Bcl-2, and p53 expressions in cervical squamous cell carcinoma treated by radiotherapy. (15350352)	Wootipoom V.... Thongsuksai P.	2004	BCL2, BAX
33	Prognostic significance of dysadherin expression in cervical squamous cell carcinoma. (15619642)	Wu D.... Suo Z.	2004	FXYD5
34	Expression of hypoxic-inducible factor 1alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma. (15380586)	Ishikawa H.... Nakano T.	2004	TP53, BCL2, BAX
35	P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma. (14599865)	Cho N.H.... Song K.J.	2003	EGFR, TP63
36	Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma. (12883684)	Okino K.... Emi M.	2003	DVL1
37	Expression of cancer/testis tumor associated antigens in cervical squamous cell carcinoma. (12759544)	Sarcevic B.... Juretic A.	2003	MAGEA4, PRAME, CTAG2
38	Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma. (12798701)	Wang P.H.... Yuan C.C.	2003	ST6GAL1
39	Retinoids, cisplatin and interferon-alpha in recurren t or metastatic cervical squamous cell carcinoma: clinical results of 2 phase I I trials. (11956030)	Braud A.C.... Viens P.	2002	IFNA1
40	HLA-DQBl alleles and susceptibility to cervical squamous cell carcinoma in Southern Iranian patients. (11994765)	Dehaghani A.S.... Ghaderi A.	2002	HLA-DQA1, HLA-DQB1, HLA-DRB1
41	c-Myc protein expression is not an independent prognostic predictor in cervical squamous cell carcinoma. (11960190)	Brenna S.M.... Syrjanen K.J.	2002	MYC
42	FHIT gene mutations and single nucleotide polymorphism in Indian oral and cervical squamous cell carcinomas. (10745171)	Kannan K.... Shanmugam G.	2000	FHIT
43	Immunohistochemical and DNA sequencing analysis on human mismatch repair gene MLH1 in cervical squamous cell carcinoma with LOH of this gene. (10769651)	Hu X.... Ponten J.	2000	MLH1
44	Increased carcinoembryonic antigen expression in cervical intraepithelial neoplasia grade 3 and in cervical squamous cell carcinoma. (11112209)	Tendler A.... Kadish A.S.	2000	CEACAM7
45	Alterations in exon 1 of c-myc and expression of p62c-myc in cervical squamous cell carcinoma. (9462237)	O'Leary J.J.... Doyle C.T.	1997	MYC
46	Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study. (8697388)	Kristensen G.B.... TropAc C.G.	1996	EGFR, CTSD
47	Expression of the proto-oncogene bcl-2 in uterine cervical squamous cell carcinoma: its relationship to clinical outcome. (8536760)	Uehara T.... Matsuzawa M.	1995	BCL2
48	Intrinsic resistance of cervical squamous cell carcinoma cell lines to methotrexate (MTX) as a result of decreased accumulation of intracellular MTX polyglutamates. (7694891)	Barakat R.R.... Bertino J.R.	1993	TYMS, DHFR
49	Expression of ras oncogene product and EGF receptor in cervical squamous cell carcinomas and its relationship to lymph node involvement. (1707025)	Hayashi Y.... Sugimori H.	1991	EGF, CDKN1A
50	Histological and immunohistochemical prediction for local control of cervical squamous cell carcinoma treated with radiotherapy alone. (2211239)	Nakano T.... Arai T.	1990	MUC1

Genes related to cervical squamous cell carcinoma according to GeneCards:

(show top 50)    (show all 93)

id	Symbol	Description	Score	GeneCards Section Context
1	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	11.0	Publications
2	CXCL14	chemokine (C-X-C motif) ligand 14	11.0
3	SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	11.0	Publications
4	KRT10	keratin 10	11.0
5	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
6	IVL	involucrin	11.0
7	KRT14	keratin 14	11.0
8	TYMP	thymidine phosphorylase	11.0	Publications
9	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications
10	KRT8	keratin 8	11.0
11	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	11.0
12	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
13	DAPK1	death-associated protein kinase 1	11.0	Publications
14	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
15	TP73	tumor protein p73	11.0	Publications
16	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0
17	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0
18	TP63	tumor protein p63	11.0	Publications
19	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
20	STAT1	signal transducer and activator of transcription 1, 91kDa	11.0
21	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
22	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications
23	EGF	epidermal growth factor	11.0	Publications
24	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
25	FHIT	fragile histidine triad	11.0	Publications
26	C19orf33	chromosome 19 open reading frame 33	11.0	Publications
27	CRCT1	cysteine-rich C-terminal 1	11.0
28	GAGE12G	G antigen 12G	11.0	Disorders
29	HOXC10	homeobox C10	11.0	Publications
30	DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9	11.0	Publications
31	IFITM1	interferon induced transmembrane protein 1	11.0	Publications
32	CTAG2	cancer/testis antigen 2	11.0	Publications
33	RPL39L	ribosomal protein L39-like	11.0
34	FXYD5	FXYD domain containing ion transport regulator 5	11.0	Publications
35	SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	11.0	Publications
36	CLEC3B	C-type lectin domain family 3, member B	11.0	Publications
37	TAAR6	trace amine associated receptor 6	11.0
38	MAGEA4	melanoma antigen family A, 4	11.0	Publications
39	LGALS9	lectin, galactoside-binding, soluble, 9	11.0	Publications
40	PRAME	preferentially expressed antigen in melanoma	11.0	Publications
41	ICOS	inducible T-cell co-stimulator	11.0	Publications
42	ACADVL	acyl-CoA dehydrogenase, very long chain	11.0	Publications
43	CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	11.0	Publications
44	BECN1	beclin 1, autophagy related	11.0	Publications
45	DVL1	dishevelled, dsh homolog 1 (Drosophila)	11.0	Publications
46	OSM	oncostatin M	11.0	Publications
47	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	11.0	Publications
48	DDR1	discoidin domain receptor tyrosine kinase 1	11.0	Publications
49	PDPN	podoplanin	11.0	Publications
50	JAG1	jagged 1	11.0	Expressions

Pathways related to cervical squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 158)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.6	TGFB1
2	Non-small cell lung cancer20	10.6	CDKN2A, EGF, FHIT, RASSF1, KRAS
3	EGFR Inhibitor Pathway, Pharmacodynamics34	10.5	KRAS
4	Graft-versus-host disease20	10.1	FASLG, HLA-A, HLA-DQA1, CD28
5	Development Thrombopoietin-regulated cell processes10	9.9	CDKN1A, CDKN1B, BIRC5, RAPGEF1, RAP1A, MYC
6	Development_Thrombopoietin-regulated cell processes41	9.9	CDKN1A, CCNA2, CDKN1B, BIRC5, RAPGEF1, RAP1A
7	Akt Signaling36	9.9	CXCL14, OSMR, OSM, DDR1, IGF1R, CD28
8	Neurotrophin signaling pathway20	9.9	NFKB1, TP73, FASLG, BAX, RAP1A, RAPGEF1
9	Intestinal immune network for IgA production20	9.7	CD28, CD40, HLA-DQA1, HLA-DQB1, HLA-DRB1, TGFB1
10	Inhibition of Matrix Metalloproteinases36	9.5	MMP14, MMP2, MMP7, MMP9, TIMP2, TIMP3
11	Cell Cycle / Checkpoint Control3	9.3	TP73, TP63, TP53, CCNA2, SKP2, CDKN2A
12	Immune response IL-22 signaling pathway10	9.3	MYC, CD28, HLA-DQA1, HLA-DQB1, HLA-DRB1, STAT3
13	Development Prolactin receptor signaling10	9.3	NFKB1, MYC, BCL2, CEBPB, TEC, STAT3
14	Measles20	9.3	STAT1, CDKN1B, CD28, FASLG, IFNA1, TP73
15	Allograft rejection20	9.3	FAS, FASLG, CD40, CD28, HLA-A, HLA-DQA1
16	Immune response_IL-22 signaling pathway41	9.3	BCL2, STAT3, HLA-DQB1, STAT1, HLA-DRB1, HLA-DQA1
17	Development_Prolactin receptor signaling41	9.3	STAT3, NFKB1, TEC, CEBPB, MYC, STAT1
18	Type I diabetes mellitus20	9.3	HLA-A, FAS, FASLG, CD28, HLA-DQA1, HLA-DQB1
19	Development_EGFR signaling pathway41	9.2	MMP9, EGF, EGFR, STAT1, MMP2, MYC
20	Toxoplasmosis20	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, CD40, BCL2, NFKB1
21	Apoptosis and Autophagy3	9.1	BIRC5, BECN1, BCL2, FASLG, BAX, FAS
22	Chronic myeloid leukemia20	9.0	CDKN1B, CDKN1A, CDKN2A, MYC, TP53, NFKB1
23	Angiogenesis3	8.9	JAG1, MMP2, TGFB1, TIMP3, TIMP2, TYMP
24	Cell adhesion ECM remodeling10	8.9	MMP14, MMP2, MMP7, IGF1R, MMP9, EGFR
25	Cell adhesion_ECM remodeling41	8.9	MMP9, MMP2, MMP14, TIMP2, MMP7, TIMP3
26	Small cell lung cancer20	8.8	NFKB1, MYC, BCL2, CDKN1B, TP53, PTGS2
27	Transcription_Androgen Receptor nuclear signaling41	8.8	EGFR, IGF1R, MMP2, CDKN1A, EGF, DVL1
28	Transcription Androgen Receptor nuclear signaling10	8.8	EGF, TGFB1, STAT3, CDKN1A, MMP2, DVL1
29	Glioblastoma Multiforme36	8.7	TP53, IGF1R, CDKN1A, EGFR, CDKN1B
30	ERK Signaling36	8.6	DDR1, EGF, EGFR, TIMP2, TGFB1, STAT1
31	Autoimmune thyroid disease20	8.6	HLA-DQB1, HLA-A, HLA-DQA1, IFNA1, FAS, FASLG
32	Apoptosis Signaling Pathways37	8.5	CDKN1A, FASLG, BIRC5, FAS, BCL2, TP53
33	Signal transduction_AKT signaling41	8.5	CDKN1B, IGF1R, TP53, FASLG, RPS6, CDKN1A
34	Tuberculosis20	8.5	BAX, STAT1, TGFB1, CTSD, HLA-DQA1, BCL2
35	Prostate cancer20	8.4	CDKN1B, BCL2, CDKN1A, EGFR, EGF, KRAS
36	Bladder cancer20	8.4	DAPK1, TP53, MMP9, MMP2, CDKN2A, CDKN1A
37	Glioma20	8.4	KRAS, CDKN1A, EGF, CDKN2A, IGF1R, TP53
38	NFAT in Immune Response36	8.3	TIMP2, TIMP3, TGFB1, EGFR, IGF1R, EGF
39	ILK Signaling36	8.2	IGF1R, DDR1, EGF, PTGS2, HIF1A, TIMP2
40	Tec Kinases Signaling36	8.1	EGF, STAT1, TIMP2, OSMR, NFKB1, TEC
41	Hepatitis C20	8.1	KRAS, EGF, EGFR, STAT3, STAT1, NFKB1
42	Mitochondrial Apoptosis36	8.0	BAX, CDKN2A, IGF1R, TP53, EGF, EGFR
43	Cellular Apoptosis Pathway36	7.8	BAX, BCL2, TIMP2, EGFR, EGF, TIMP3
44	p38 Signaling36	7.5	TGFB1, TIMP2, EGFR, BAX, TIMP3, BCL2
45	JAK-STAT Pathway36	7.5	IFNA1, STAT1, BCL2, BAX, IGF1R, MYC
46	MAPK Signaling36	7.2	TIMP2, TIMP3, TGFB1, STAT1, RAP1A, EGFR
47	Molecular Mechanisms of Cancer36	7.0	RAP1A, MYC, TP53, RAPGEF1, BCL2, TGFB1
48	Colorectal Cancer Metastasis36	6.9	MMP9, MMP7, MMP2, MMP14, BAX, BIRC5
49	Pancreatic Adenocarcinoma36	6.3	NFKB1, EGF, EGFR, TIMP2, TIMP3, TGFB1
50	Pathways in cancer20	5.9	STAT3, IGF1R, FAS, MMP2, CDKN1B, CDKN1A

Compounds related to cervical squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 289)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.5	RAP1A, CDKN1B, DAPK1, CTLA4, KRT8, KRT10
2	glucose32	10.5	MKI67, CCNA2, RPS6, KRT8, TYMP, TOLLIP
3	vincristine32 34 9 9	13.1	IFNA1
4	h2o232	10.0	CD40, IGF1R, DVL1, DHFR, STAT1
5	sp 60012532 42	10.9	CDKN1A, CD40, TP53
6	rapamycin32 42	10.6	BECN1, CCNA2, IGF1R, KRAS, EGF, EGFR
7	p00232	9.4	BIRC5, CEACAM5, MMP14, MMP7, MMP9, MLH1
8	bromodeoxyuridine32	9.2	MYC, CDKN1A, CDKN1B, IVL, MMP14, MLH1
9	agar32	9.2	RAP1A, RASSF1, BIRC5, MUC1, CEACAM5, CDKN1B
10	12-o-tetradecanoylphorbol 13-acetate32	9.0	MYC, RAP1A, CEBPB, CDKN1A, CDKN1B, IVL
11	crcs32	8.8	RASSF1, BIRC5, MUC1, CEACAM5, CDKN2A, MLH1
12	pge232	8.7	RAP1A, IVL, FASLG, IGF1R, CTSD, EGF
13	sb 20358032 42	9.6	BSG, BIRC5, BCL2, CDKN1A, CDKN1B, IVL
14	mg 13232 42	9.6	MYC, BIRC5, BAX, CEBPB, CDKN1A, CDKN1B
15	ly29400232	8.6	CDKN1B, MMP14, MMP2, MMP9, FASLG, CCNA2
16	agarose32	8.5	MYC, BCL2, MUC1, BAX, CDKN1A, CDKN2A
17	progesterone32 42 9 18 9	12.5	BSG, BIRC5, BCL2, CEACAM5, CEACAM7, CEBPB
18	camptothecin32 42 9 9	11.2	MYC, BIRC5, BCL2, BAX, CDKN1A, CDKN1B
19	mitomycin c32	8.0	BIRC5, CEACAM5, CD40, FASLG, FAS, IGF1R
20	gefitinib32 34 9 9	11.0	BIRC5, CEACAM5, CEACAM7, CDKN1A, CDKN1B, MMP2
21	estrogen32	7.8	BSG, RASSF1, CEACAM5, CEACAM7, IVL, MMP14
22	imatinib32 34 9 9	10.8	MYC, BIRC5, BCL2, CDKN1A, CDKN1B, FASLG
23	oxaliplatin32 34 9 9	10.7	BIRC5, CEACAM5, CDKN1A, MLH1, FAS, CCNA2
24	methotrexate32 34 42 9 9	11.6	BIRC5, MUC1, CDKN1B, CDKN2A, CD40, IVL
25	herbimycin a32 42	8.5	MYC, CD28, CD40, MMP14, MMP2, MMP9
26	cysteine32	7.3	SERPINB4, MUC1, CEACAM5, CDKN2A, CD40, IVL
27	n acetylcysteine32	7.1	BIRC5, CEBPB, CDKN1A, CDKN1B, CDKN2A, CD40
28	5-aza-2deoxycytidine32	7.1	MYC, RASSF1, CDKN1A, CDKN2A, MLH1, FHIT
29	cytarabine32 34 9 9	10.1	MYC, BCL2, MUC1, BAX, CDKN1A, CDKN1B
30	irinotecan32 34 9 9	10.0	BAX, CEACAM5, CDKN1A, CDKN2A, MLH1, MKI67
31	curcumin32	6.5	MYC, BIRC5, BCL2, BAX, CDKN1A, IVL
32	thymidylate32	6.3	BIRC5, BCL2, BAX, CDKN1A, CDKN2A, MLH1
33	retinoic acid32 42 18	8.3	MYC, RASSF1, BIRC5, BAX, CEBPB, CDKN1A
34	etoposide32 42 9 9	9.3	MYC, BIRC5, BCL2, BAX, CDKN1A, CDKN1B
35	arsenite32 18	7.2	MYC, BIRC5, BECN1, BCL2, BAX, CDKN1A
36	gemcitabine32 34 9 9	8.9	MYC, BIRC5, BCL2, MUC1, BAX, CDKN1A
37	butyrate32	5.8	MYC, BIRC5, BCL2, MUC1, BAX, CEACAM5
38	pd 98,05932	5.7	MYC, BIRC5, BCL2, BAX, CEBPB, CDKN1A
39	vegf32	5.7	BSG, MYC, RAP1A, BCL2, MUC1, CEACAM5
40	dexamethasone32 42 34 9 9	9.6	MYC, BIRC5, CLEC3B, BCL2, MUC1, CEBPB
41	adriamycin32	5.5	MYC, BIRC5, BCL2, MUC1, BAX, CEACAM5
42	phosphatidylinositol32	5.4	MYC, RAP1A, BIRC5, BCL2, LGALS9, BAX
43	actinomycin d32	5.3	MYC, BIRC5, BCL2, MUC1, BAX, CEACAM7
44	thymidine32 18	6.3	MYC, BIRC5, MUC1, CEACAM5, CEACAM7, CDKN1A
45	paclitaxel32 34 9 9	8.3	MYC, BIRC5, BCL2, BAX, CDKN1A, CDKN1B
46	tamoxifen32 34 9 9	8.2	MYC, BIRC5, BCL2, MUC1, BAX, CDKN1A
47	paraffin32	4.1	MYC, BIRC5, BCL2, MUC1, BAX, CEACAM5
48	cisplatin32 34 9 9	7.0	MYC, RASSF1, BIRC5, BCL2, MUC1, BAX
49	tyrosine32	3.4	BSG, MYC, RAP1A, BIRC5, MUC1, CEACAM5
50	serine32	3.0	SERPINB3, SERPINB4, BSG, MYC, RAP1A, RASSF1

Cellular components related to cervical squamous cell carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ER to Golgi transport vesicle membrane	GO:012507	9.7	HLA-A, HLA-DQA1, HLA-DQB1, HLA-DRB1
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.6	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-A
3	external side of plasma membrane	GO:009897	9.3	CTLA4, HLA-DRB1, ICOS, FAS, FASLG, CD40
4	integral to plasma membrane	GO:005887	8.4	ICOS, HLA-A, HLA-DQA1, HLA-DRB1, DDR1, CTLA4
5	nucleoplasm	GO:005654	7.9	SKP2, KRT8, HIF1A, TYMS, STAT3, STAT1
6	extracellular region	GO:005576	7.5	ICOS, HMGB1, DDR1, CTSD, EGF, TIMP2
7	cytosol	GO:005829	6.3	HIF1A, KRT14, SKP2, NFKB1, RPS6, TYMP
8	cytoplasm	GO:005737	4.6	STAT1, KRT10, KRT8, NFKB1, RPS6, DAPK1

Biological processes related to cervical squamous cell carcinoma according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of phosphorylation	GO:042326	10.6	GRB10, CDKN2A, CDKN1B, CDKN1A
2	cellular response to organic substance	GO:071310	10.3	TIMP3, TIMP2, BAX, BCL2, CLEC3B
3	apoptotic DNA fragmentation	GO:006309	10.1	HMGB1, CDKN2A, BAX, MYC
4	negative regulation of survival gene product expression	GO:008634	10.1	SKP2, BAX, MYC
5	extracellular matrix disassembly	GO:022617	10.0	TIMP2, MMP9, MMP7, MMP2, MMP14
6	positive regulation of MAP kinase activity	GO:043406	10.0	TGFB1, EGFR, EGF, KRAS, CD40
7	T cell costimulation	GO:031295	9.9	CTLA4, HLA-DRB1, HLA-DQB1, HLA-DQA1, ICOS, CD28
8	interferon-gamma-mediated signaling pathway	GO:060333	9.9	STAT1, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-A
9	mitotic cell cycle arrest	GO:071850	9.7	TP53, CDKN1B, CDKN1A
10	Ras protein signal transduction	GO:007265	9.7	KRAS, TP53, CCNA2, CDKN2A, CDKN1A, RASSF1
11	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.6	FAS, FASLG, CDKN2A, CDKN1B, BAX, MYC
12	cytokine-mediated signaling pathway	GO:019221	9.6	STAT1, STAT3, KRAS, HLA-DRB1, HLA-DQB1, HLA-DQA1
13	digestive tract morphogenesis	GO:048546	9.6	HIF1A, EGFR, TP73, BCL2
14	induction of apoptosis	GO:006917	9.6	STAT1, TGFB1, DAPK1, TP63, FAS, FASLG
15	activation of pro-apoptotic gene products	GO:008633	9.5	FAS, FASLG, BAX, BCL2, MYC
16	ossification	GO:001503	9.5	EGFR, IFITM1, MMP9, BCL2, CLEC3B
17	cell cycle arrest	GO:007050	9.4	TGFB1, TP73, TP53, CDKN2A, CDKN1B, CDKN1A
18	release of cytochrome c from mitochondria	GO:001836	9.3	TP73, TP53, BAX, BCL2, MYC
19	replicative senescence	GO:090399	9.3	TP53, CDKN2A, CDKN1A
20	negative regulation of cell growth	GO:030308	9.3	TGFB1, TP53, CDKN2A, CDKN1B, CDKN1A, BCL2
21	inflammatory response	GO:006954	9.3	TGFB1, TOLLIP, PDPN, NFKB1, PTGS2, TP73
22	induction of apoptosis by intracellular signals	GO:008629	9.2	TP53, CDKN1A, BAX, BCL2, MYC
23	protein tetramerization	GO:051262	9.2	TP73, TP53, HLA-DRB1, IGF1R
24	response to gamma radiation	GO:010332	9.2	MYC, BCL2, BAX, TP53
25	negative regulation of cell proliferation	GO:008285	9.1	OSM, TGFB1, TIMP2, PTGS2, TP53, IFITM1
26	response to DNA damage stimulus	GO:006974	9.1	CTLA4, TP73, TP53, CDKN1A, BAX, BCL2
27	neuron apoptotic process	GO:051402	9.1	TP63, TP53, FAS, BAX, BCL2
28	immune response	GO:006955	9.0	HLA-DQB1, HLA-DRB1, CTLA4, OSM, CXCL14, HLA-DQA1
29	anti-apoptosis	GO:006916	8.8	NFKB1, DAPK1, IGF1R, FAS, CEBPB, MUC1
30	positive regulation of cell proliferation	GO:008284	8.6	MYC, PRAME, OSMR, OSM, TGFB1, EGFR
31	response to drug	GO:042493	8.5	STAT3, TGFB1, PTGS2, FAS, MMP9, MMP7
32	positive regulation of apoptotic process	GO:043065	8.3	RPS6, CTLA4, PTGS2, TP53, HMGB1, FAS
33	positive regulation of transcription, DNA-dependent	GO:045893	8.2	STAT1, STAT3, TGFB1, DVL1, HIF1A, EGF
34	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.1	NFKB1, HIF1A, TGFB1, STAT3, STAT1, OSM
35	negative regulation of apoptotic process	GO:043066	8.0	PRAME, EGFR, TP53, IGF1R, CDKN1B, CDKN1A
36	apoptotic process	GO:006915	7.9	TP63, DAPK1, NFKB1, OSM, PRAME, TP53
37	signal transduction	GO:007165	7.6	STAT3, DVL1, TOLLIP, HIF1A, EGFR, EGF

Molecular functions related to cervical squamous cell carcinoma according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.1	CDKN2A, CDKN1B, CDKN1A
2	MHC class II receptor activity	GO:032395	9.9	HLA-DQA1, HLA-DQB1, HLA-DRB1
3	double-stranded DNA binding	GO:003690	9.3	STAT1, EGFR, C19orf33, NFKB1, HMGB1, MYC
4	signal transducer activity	GO:004871	9.1	STAT1, STAT3, DVL1, TOLLIP, HIF1A, FAS
5	protein kinase binding	GO:019901	8.5	STAT3, DVL1, HIF1A, RPS6, TP73, TP53
6	transcription factor binding	GO:008134	8.4	STAT3, HIF1A, TP73, TP53, HMGB1, CDKN2A
7	enzyme binding	GO:019899	8.1	STAT1, TGFB1, DVL1, HIF1A, EGFR, PTGS2
8	protein heterodimerization activity	GO:046982	7.6	TGFB1, HIF1A, EGFR, TP53, CEBPB, BAX
9	identical protein binding	GO:042802	7.5	TP63, TP73, SKP2, EGFR, DVL1, TP53
10	protein binding	GO:005515	2.6	HLTF, NFKB1, RPS6, CTLA4, DAPK1, DDR1