MCID: CRV038
MIFTS: 49

Cervical Squamous Cell Carcinoma malady

Cancer diseases category

Summaries for Cervical Squamous Cell Carcinoma

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Disease Ontology:9 A cervix carcinoma that has material basis in squamous cells of the cervix.

MalaCards based summary: Cervical Squamous Cell Carcinoma, also known as squamous cell carcinoma of the cervix uteri, is related to cervical intraepithelial neoplasia and adenosquamous carcinoma. An important gene associated with Cervical Squamous Cell Carcinoma is SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Matrix Metalloproteinases. The compounds calcipotriol and ethylenediaminetetraacetic acid have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and ovary, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Aliases & Classifications for Cervical Squamous Cell Carcinoma

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Cervical Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Cervical Squamous Cell Carcinoma 31 9 11 44 61
Squamous Cell Carcinoma of the Cervix Uteri 9 61
 
Squamous Cell Carcinoma of Cervix 9 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:3744
SNOMED-CT56 254886006
NCIt39 C4028

Related Diseases for Cervical Squamous Cell Carcinoma

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Diseases related to Cervical Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia30.8TP73, KRT8, KRT10
2adenosquamous carcinoma30.8KRT8, TYMP
3cervical adenocarcinoma30.6KRT8, RASSF1
4papilloma30.0TP73, RASSF1, KRT10, KRT14
5adenocarcinoma28.9DAPK1, TYMP, KRT14, KRT10, KRT8, RASSF1
6cervicitis11.4
7microinvasive cervical squamous cell carcinoma10.5
8cardiac tamponade10.4
9neuroendocrine carcinoma10.4
10small cell neuroendocrine carcinoma10.4
11endometrial adenocarcinoma10.4
12keratoacanthoma10.4
13serous cystadenocarcinoma10.3TYMP, MMP14
14bowen syndrome10.3KRT14, KRT10
15keratinizing squamous cell carcinoma10.3
16fibrous histiocytoma10.3
17anal squamous cell carcinoma10.3
18histiocytoma10.3
19sarcoma10.3
20epidermolysis bullosa simplex10.3KRT10, KRT14
21nonepidermolytic palmoplantar keratoderma10.3KRT10, KRT14
22pancreatic ductal carcinoma10.3KRT8, TYMP
23laryngeal benign neoplasm10.2SERPINB3, MMP14
24cholesteatoma10.2KRT14, KRT10
25endocervicitis10.2
26breast adenocarcinoma10.2
27cervical carcinosarcoma10.2
28dermatomyositis10.2
29vaginitis10.2
30neuroendocrine carcinoma of the cervix10.2
31rare squamous cell carcinoma of the cervix uteri10.2
32craniopharyngioma10.2KRT8, KRT14
33chordoma10.2KRT14, KRT8
34angiosarcoma10.2KRT8, KRT14
35ameloblastoma10.2KRT14, KRT8
36skin disease10.2KRT10, KRT14, CD40
37bladder carcinoma in situ10.1RASSF1, SERPINB3
38abdominal aortic aneurysm10.1TIMP2, MMP14
39plasma cell leukemia10.1TP73, CD40
40breast ductal carcinoma10.1KRT8, TIMP2
41keloids10.1KRT14, TIMP2
42psoriasis10.1SERPINB3, KRT10, KRT14, CD40
43endometriosis10.1TYMP, TIMP2, MMP14
44gallbladder cancer10.1KRT8, TIMP2, TYMP
45kidney rhabdoid cancer10.1RASSF1, TYMP
46oxyphilic adenoma10.1RASSF1, KRT8, KRT14
47synovial sarcoma10.1KRT14, KRT8, RASSF1
48hepatitis b10.0TYMP, SERPINB3, MMP14, KRT8
49familial adenomatous polyposis10.0DAPK1, MMP14, RASSF1
50cholangiocarcinoma10.0KRT8, RASSF1, DAPK1

Graphical network of the top 20 diseases related to Cervical Squamous Cell Carcinoma:



Diseases related to cervical squamous cell carcinoma

Symptoms for Cervical Squamous Cell Carcinoma

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Drugs & Therapeutics for Cervical Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Cervical Squamous Cell Carcinoma

Search NIH Clinical Center for Cervical Squamous Cell Carcinoma

Genetic Tests for Cervical Squamous Cell Carcinoma

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Anatomical Context for Cervical Squamous Cell Carcinoma

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MalaCards organs/tissues related to Cervical Squamous Cell Carcinoma:

32
Cervix, Lymph node, Ovary, Placenta, Testes, Lung, Breast, Skin, Testis

Animal Models for Cervical Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Cervical Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.7TP73, MMP14, KRT10, KRT14
2MP:00053828.6KRT14, KRT10, MMP14, TP73
3MP:00020068.1TP73, RASSF1, KRT10, KRT14
4MP:00053977.5TP73, TIMP2, MMP14, KRT8, KRT14, CD40
5MP:00053847.5DAPK1, TYMP, TP73, MMP14, RASSF1, KRT14
6MP:00036317.4DAPK1, TYMP, TP73, TIMP2, MMP14, CD40
7MP:00053766.7DAPK1, TYMP, TP73, TIMP2, MMP14, RASSF1
8MP:00053876.5CD40, TYMP, TP73, TIMP2, MMP14, RASSF1

Publications for Cervical Squamous Cell Carcinoma

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Articles related to Cervical Squamous Cell Carcinoma:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
Cervical squamous cell carcinoma with isolated tibial metastasis: A case report and review of the literature. (25364422)
2014
2
Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma. (24659184)
2014
3
IMP3 expression is associated with poor survival in cervical squamous cell carcinoma. (25176620)
2014
4
Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery. (24405714)
2014
5
Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells. (24689999)
2014
6
Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics. (24385692)
2013
7
Case of metastatic uterine cervical squamous cell carcinoma in the right atrium. (23564576)
2013
8
Primary Squamous Cell Carcinoma of the Upper Genital Tract: Utility of p16(INK4a) Expression and HPV DNA Status in its Differential Diagnosis from Extended Cervical Squamous Cell Carcinoma. (24421848)
2013
9
Genetic variants in interleukin-18 gene and risk for cervical squamous cell carcinoma. (23603311)
2013
10
ERCC1 mRNA levels can predict the response to cisplatin-based concurrent chemoradiotherapy of locally advanced cervical squamous cell carcinoma. (23259415)
2012
11
Screening test results associated with cancer diagnoses in 287 women with cervical squamous cell carcinoma. (22900617)
2012
12
Recurrence during pregnancy of a conservatively treated early-stage cervical squamous cell carcinoma. (20655526)
2011
13
Laparoscopic adrenalectomy for isolated adrenal metastasis from cervical squamous cell carcinoma and endometrial adenocarcinoma. (21664660)
2011
14
Two novel unbalanced whole arm translocations are frequently detected in cervical squamous cell carcinoma. (22285016)
2011
15
Reduced expression of I9I9p63I+ inA cervical squamous cell carcinoma. (21631996)
2011
16
Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma. (21319225)
2011
17
Influence of lymph vascular space invasion on prognosis of patients with early-stage cervical squamous cell carcinoma. (20346220)
2010
18
Expression of PSCA, PIWIL1 and TBX2 and its correlation with HPV16 infection in formalin-fixed, paraffin-embedded cervical squamous cell carcinoma specimens. (20229117)
2010
19
Significant effects of lymph and blood vascular invasion on the prognosis of early-stage cervical squamous cell carcinoma. (20846259)
2010
20
Plasma proteome analysis of cervical intraepithelial neoplasia and cervical squamous cell carcinoma. (20093745)
2009
21
Cyclooxygenase-2 expression in cervical squamous cell carcinoma: the significance of expression in neoplastic cells within the lymphovascular space. (20192574)
2009
22
Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma. (19638983)
2009
23
Microarray profile of micro-ribonucleic acid in tumor tissue from cervical squamous cell carcinoma without human papillomavirus. (20149030)
2009
24
Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy. (19030960)
2008
25
Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. (17503414)
2007
26
Early determination of uterine cervical squamous cell carcinoma radioresponse identifies high- and low-response tumors. (16343805)
2006
27
Expression and clinical significance of autophagy gene Beclin 1 in cervical squamous cell carcinoma]. (17236580)
2006
28
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. (16425263)
2006
29
HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and meta-analysis. (16720214)
2006
30
Tumor lymphangiogenesis in cervical squamous cell carcinoma and its clinical significance]. (16179117)
2005
31
Cell proliferation of bulky cervical squamous cell carcinoma is strongly associated with a paracrine tissue-specific growth factor(s). (16211274)
2005
32
P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma. (14599865)
2003
33
Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma. (12798701)
2003
34
Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia. (12100520)
2002
35
Chlamydia trachomatis and cervical squamous cell carcinoma. (11277820)
2001
36
Karyometric features differentiate early invasive cervical squamous cell carcinoma from preinvasive carcinoma. (11915180)
2001
37
Increased carcinoembryonic antigen expression in cervical intraepithelial neoplasia grade 3 and in cervical squamous cell carcinoma. (11112209)
2000
38
Relative changes of MIB1 and PC10 labeling indexes in cell kinetics during radiotherapy for cervical squamous cell carcinoma. (9490095)
1997
39
Possible involvement of tumour-derived interleukin-6 in dermatomyositis associated with cervical squamous cell carcinoma. (9115948)
1997
40
Expression of retinoic acid receptor-beta 2 mRNA in normal cervical epithelium and cervical squamous cell carcinoma. (21528293)
1997
41
Cervical squamous cell carcinoma and its precursor lesions: cytodiagnostic criteria and pitfalls. (9390926)
1996
42
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study. (8697388)
1996
43
Angiogenesis in uterine cervical squamous cell carcinoma. (8601522)
1995
44
Age is prognostic variable in cervical squamous cell carcinoma. (8344321)
1993
45
Intrinsic resistance of cervical squamous cell carcinoma cell lines to methotrexate (MTX) as a result of decreased accumulation of intracellular MTX polyglutamates. (7694891)
1993
46
Expression of ras oncogene product and EGF receptor in cervical squamous cell carcinomas and its relationship to lymph node involvement. (1707025)
1991
47
Keratoacanthomas associated with cervical squamous cell carcinoma. (4004294)
1985
48
Tumor-antigen TA-4 in the detection of recurrence in cervical squamous cell carcinoma. (6478396)
1984
49
Tumor antigen of human cervical squamous cell carcinoma: correlation of circulating levels with disease progress. (421183)
1979
50
Biological properties and radiation responses of the hamster uterine cervical squamous cell carcinoma. (441259)
1979

Variations for Cervical Squamous Cell Carcinoma

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Expression for genes affiliated with Cervical Squamous Cell Carcinoma

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LifeMap Discovery
Genes differentially expressed in tissues of Cervical Squamous Cell Carcinoma patients vs. healthy controls: 31 (show all 339)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CRNNcornulinUterus-5.620.000
2KRT1keratin 1Uterus-5.320.000
3UPK1Auroplakin 1AUterus-4.790.000
4MALmal, T-cell differentiation proteinUterus-4.730.000
5KRT4keratin 4Uterus-4.450.000
6SPRR3small proline-rich protein 3Uterus-4.430.000
7DSG1desmoglein 1Uterus-4.270.000
8CDKN2Acyclin-dependent kinase inhibitor 2AUterus+4.210.000
9CRISP3cysteine-rich secretory protein 3Uterus-4.130.000
10CRCT1cysteine-rich C-terminal 1Uterus-3.920.000
11SPINK5serine peptidase inhibitor, Kazal type 5Uterus-3.670.000
12SLURP1secreted LY6/PLAUR domain containing 1Uterus-3.540.000
13APOC1apolipoprotein C-IUterus+3.530.000
14HOPXHOP homeoboxUterus-3.510.000
15EDN3endothelin 3Uterus-3.480.000
16FANCIFanconi anemia, complementation group IUterus+3.420.000
17SYNGR3synaptogyrin 3Uterus+3.410.000
18CRYABcrystallin, alpha BUterus-3.390.000
19KRT13keratin 13Uterus-3.350.004
20MCM5minichromosome maintenance complex component 5Uterus+3.310.000
21ALOX12arachidonate 12-lipoxygenaseUterus-3.260.000
22PPP1R3Cprotein phosphatase 1, regulatory subunit 3CUterus-3.230.000
23SCELsciellinUterus-3.190.000
24NTSneurotensinUterus+3.190.006
25NUSAP1nucleolar and spindle associated protein 1Uterus+3.170.000
26IVLinvolucrinUterus-3.140.000
27IL1R2interleukin 1 receptor, type IIUterus-3.140.000
28CFDcomplement factor D (adipsin)Uterus-3.130.000
29SOSTDC1sclerostin domain containing 1Uterus-3.080.000
30ESR1estrogen receptor 1Uterus-3.060.000
31PAMR1peptidase domain containing associated with muscle regeneration 1Uterus-3.060.000
32ENDOUendonuclease, polyU-specificUterus-3.040.000
33HOXC6homeobox C6Uterus+3.010.000
34APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BUterus+3.000.000
35OLFM4olfactomedin 4Uterus-2.920.002
36KLK11kallikrein-related peptidase 11Uterus-2.800.000
37LHX2LIM homeobox 2Uterus+2.790.001
38RHCGRh family, C glycoproteinUterus-2.760.002
39EREGepiregulinUterus-2.750.000
40BBOX1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1Uterus-2.710.000
41FAM107Afamily with sequence similarity 107, member AUterus-2.710.000
42AURKAaurora kinase AUterus+2.680.000
43ECT2epithelial cell transforming 2Uterus+2.650.000
44FN1fibronectin 1Uterus+2.610.012
45FOSBFBJ murine osteosarcoma viral oncogene homolog BUterus-2.560.019
46CXCL13chemokine (C-X-C motif) ligand 13Uterus+2.540.012
47ID4inhibitor of DNA binding 4, dominant negative helix-loop-helix proteinUterus-2.530.000
48MCM2minichromosome maintenance complex component 2Uterus+2.510.000
49MUC1mucin 1, cell surface associatedUterus+2.500.032
50CXCL12chemokine (C-X-C motif) ligand 12Uterus-2.480.003
51DTLdenticleless E3 ubiquitin protein ligase homolog (Drosophila)Uterus+2.470.000
52SPARCL1SPARC-like 1 (hevin)Uterus-2.470.002
53SPRR1Asmall proline-rich protein 1AUterus-2.450.041
54WHSC1Wolf-Hirschhorn syndrome candidate 1Uterus+2.430.000
55AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)Uterus-2.410.002
56SPP1secreted phosphoprotein 1Uterus+2.400.003
57ISG20interferon stimulated exonuclease gene 20kDaUterus+2.400.001
58KIF20Akinesin family member 20AUterus+2.380.000
59GREB1growth regulation by estrogen in breast cancer 1Uterus-2.380.001
60IL18interleukin 18 (interferon-gamma-inducing factor)Uterus-2.380.000
61CCL20chemokine (C-C motif) ligand 20Uterus+2.370.035
62RFC4replication factor C (activator 1) 4, 37kDaUterus+2.360.000
63NCAPHnon-SMC condensin I complex, subunit HUterus+2.350.000
64CRABP2cellular retinoic acid binding protein 2Uterus-2.330.000
65NASPnuclear autoantigenic sperm protein (histone-binding)Uterus+2.320.000
66KLK7kallikrein-related peptidase 7Uterus-2.300.006
67ZSCAN18zinc finger and SCAN domain containing 18Uterus-2.300.000
68OCA2oculocutaneous albinism IIUterus-2.300.000
69MAOBmonoamine oxidase BUterus-2.290.000
70PLOD2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2Uterus+2.290.000
71MYBL2v-myb avian myeloblastosis viral oncogene homolog-like 2Uterus+2.290.000
72ENO2enolase 2 (gamma, neuronal)Uterus+2.280.003
73HSPB8heat shock 22kDa protein 8Uterus-2.270.001
74RPL39Lribosomal protein L39-likeUterus+2.250.000
75CXCR2chemokine (C-X-C motif) receptor 2Uterus-2.250.000
76HPGDhydroxyprostaglandin dehydrogenase 15-(NAD)Uterus-2.240.000
77IFI44Linterferon-induced protein 44-likeUterus+2.220.024
78THSD4thrombospondin, type I, domain containing 4Uterus-2.220.000
79SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2Uterus-2.220.011
80CLDN8claudin 8Uterus-2.210.000
81TOP2Atopoisomerase (DNA) II alpha 170kDaUterus+2.210.000
82PTK6protein tyrosine kinase 6Uterus-2.200.002
83SLC16A7solute carrier family 16 (monocarboxylate transporter), member 7Uterus-2.180.000
84CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Uterus+2.160.005
85KNTC1kinetochore associated 1Uterus+2.160.000
86GYS2glycogen synthase 2 (liver)Uterus-2.150.001
87ALOX12Barachidonate 12-lipoxygenase, 12R typeUterus-2.150.001
88FGFR2fibroblast growth factor receptor 2Uterus-2.150.004
89WARStryptophanyl-tRNA synthetaseUterus+2.130.000
90TMPRSS11Dtransmembrane protease, serine 11DUterus-2.130.006
91CXCL14chemokine (C-X-C motif) ligand 14Uterus-2.130.046
92RRAGDRas-related GTP binding DUterus-2.130.031
93EPB42erythrocyte membrane protein band 4.2Uterus-2.120.000
94ISL1ISL LIM homeobox 1Uterus-2.120.002
95HMMRhyaluronan-mediated motility receptor (RHAMM)Uterus+2.120.000
96SPRR1Bsmall proline-rich protein 1BUterus-2.110.014
97ARCactivity-regulated cytoskeleton-associated proteinUterus-2.110.019
98PRSS3protease, serine, 3Uterus-2.100.000
99SCGB2A1secretoglobin, family 2A, member 1Uterus-2.100.027
100RIBC2RIB43A domain with coiled-coils 2Uterus+2.100.001
101GLTPglycolipid transfer proteinUterus-2.090.000
102CKS1BCDC28 protein kinase regulatory subunit 1BUterus+2.090.000
103CLCA4chloride channel accessory 4Uterus-2.090.048
104NEK2NIMA-related kinase 2Uterus+2.080.000
105GAD1glutamate decarboxylase 1 (brain, 67kDa)Uterus+2.080.032
106UCP2uncoupling protein 2 (mitochondrial, proton carrier)Uterus+2.080.002
107KLK10kallikrein-related peptidase 10Uterus-2.080.013
108NDNnecdin, melanoma antigen (MAGE) family memberUterus-2.070.001
109ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Uterus+2.060.001
110LAMP3lysosomal-associated membrane protein 3Uterus+2.050.004
111MLF1myeloid leukemia factor 1Uterus+2.050.002
112PITX1paired-like homeodomain 1Uterus-2.050.010
113TIPINTIMELESS interacting proteinUterus+2.050.000
114GSTA4glutathione S-transferase alpha 4Uterus-2.050.000
115PTGDSprostaglandin D2 synthase 21kDa (brain)Uterus-2.050.004
116TRIOtrio Rho guanine nucleotide exchange factorUterus+2.040.002
117TMPRSS11Etransmembrane protease, serine 11EUterus-2.040.003
118TK1thymidine kinase 1, solubleUterus+2.030.000
119LORloricrinUterus-2.020.019
120ARandrogen receptorUterus-2.010.000
121IGF1insulin-like growth factor 1 (somatomedin C)Uterus-2.010.038
122APOEapolipoprotein EUterus+2.000.032
123CDAcytidine deaminaseUterus-2.000.005
124COL9A1collagen, type IX, alpha 1Uterus-1.990.001
125AIM2absent in melanoma 2Uterus+1.990.007
126SPON1spondin 1, extracellular matrix proteinUterus-1.990.002
127TTC39Atetratricopeptide repeat domain 39AUterus-1.980.001
128E2F1E2F transcription factor 1Uterus+1.980.000
129UPP1uridine phosphorylase 1Uterus-1.970.006
130TP53I3tumor protein p53 inducible protein 3Uterus-1.970.001
131CENPNcentromere protein NUterus+1.970.001
132KCTD7potassium channel tetramerization domain containing 7Uterus+1.960.001
133FOXM1forkhead box M1Uterus+1.950.000
134ANKRD36Bankyrin repeat domain 36BUterus+1.950.003
135SLC24A3solute carrier family 24 (sodium/potassium/calcium exchanger), member 3Uterus-1.940.003
136DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 1Uterus-1.940.000
137DIO2deiodinase, iodothyronine, type IIUterus-1.930.031
138CD24CD24 moleculeUterus-1.920.012
139SPRR2Bsmall proline-rich protein 2BUterus-1.920.031
140TNFSF10tumor necrosis factor (ligand) superfamily, member 10Uterus+1.910.002
141ITGA6integrin, alpha 6Uterus+1.910.014
142SLC6A8solute carrier family 6 (neurotransmitter transporter), member 8Uterus+1.900.047
143GJA1gap junction protein, alpha 1, 43kDaUterus-1.900.039
144SYCP2synaptonemal complex protein 2Uterus+1.900.003
145CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 7Uterus-1.890.000
146SOX4SRY (sex determining region Y)-box 4Uterus+1.890.003
147MELKmaternal embryonic leucine zipper kinaseUterus+1.880.000
148GINS2GINS complex subunit 2 (Psf2 homolog)Uterus+1.880.002
149FCGBPFc fragment of IgG binding proteinUterus-1.870.017
150EPB41L3erythrocyte membrane protein band 4.1-like 3Uterus-1.870.001
151IFI16interferon, gamma-inducible protein 16Uterus+1.870.003
152PI3peptidase inhibitor 3, skin-derivedUterus-1.860.031
153PRC1protein regulator of cytokinesis 1Uterus+1.860.000
154IGF2BP2insulin-like growth factor 2 mRNA binding protein 2Uterus+1.860.010
155GPX3glutathione peroxidase 3 (plasma)Uterus-1.860.003
156KRT17keratin 17Uterus+1.860.039
157DCNdecorinUterus-1.860.013
158TAZtafazzinUterus+1.850.015
159LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homologUterus+1.850.009
160DKK3dickkopf WNT signaling pathway inhibitor 3Uterus-1.850.018
161CDK1cyclin-dependent kinase 1Uterus+1.840.001
162KRT6Bkeratin 6BUterus-1.840.028
163CENPFcentromere protein F, 350/400kDaUterus+1.840.000
164PDGFDplatelet derived growth factor DUterus-1.830.000
165MPZL2myelin protein zero-like 2Uterus-1.830.006
166KIAA0101KIAA0101Uterus+1.820.000
167SYT17synaptotagmin XVIIUterus+1.820.015
168DSC2desmocollin 2Uterus-1.820.007
169ACOT9acyl-CoA thioesterase 9Uterus+1.820.003
170SHARPINSHANK-associated RH domain interactorUterus+1.820.006
171ATP2C1ATPase, Ca++ transporting, type 2C, member 1Uterus+1.810.001
172EMP1epithelial membrane protein 1Uterus-1.810.008
173HJURPHolliday junction recognition proteinUterus+1.810.001
174SNAPC4small nuclear RNA activating complex, polypeptide 4, 190kDaUterus+1.810.015
175KIF4Akinesin family member 4AUterus+1.800.000
176PCNAproliferating cell nuclear antigenUterus+1.790.000
177GINS1GINS complex subunit 1 (Psf1 homolog)Uterus+1.790.003
178EPCAMepithelial cell adhesion moleculeUterus+1.790.011
179EIF1eukaryotic translation initiation factor 1Uterus-1.790.013
180SAT1spermidine/spermine N1-acetyltransferase 1Uterus+1.780.017
181MAGOHBmago-nashi homolog B (Drosophila)Uterus+1.780.005
182RECQL4RecQ protein-like 4Uterus+1.780.003
183RRM2ribonucleotide reductase M2Uterus+1.770.001
184SRSF10serine/arginine-rich splicing factor 10Uterus+1.770.001
185SAC3D1SAC3 domain containing 1Uterus+1.770.006
186HBBhemoglobin, betaUterus-1.770.022
187CWH43cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)Uterus-1.770.003
188CALML3calmodulin-like 3Uterus-1.760.027
189CCND1cyclin D1Uterus-1.760.000
190MALLmal, T-cell differentiation protein-likeUterus-1.760.048
191METmet proto-oncogeneUterus+1.760.010
192C1orf116chromosome 1 open reading frame 116Uterus-1.750.024
193ALCAMactivated leukocyte cell adhesion moleculeUterus+1.750.033
194TSTthiosulfate sulfurtransferase (rhodanese)Uterus-1.740.001
195FOXD1forkhead box D1Uterus+1.740.002
196LYPD3LY6/PLAUR domain containing 3Uterus-1.740.018
197SPAG5sperm associated antigen 5Uterus+1.730.000
198MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)Uterus+1.730.002
199NOD2nucleotide-binding oligomerization domain containing 2Uterus-1.730.013
200SMC4structural maintenance of chromosomes 4Uterus+1.730.001
201NSG1neuron specific gene family member 1Uterus-1.730.002
202E2F3E2F transcription factor 3Uterus+1.720.000
203SFTPDsurfactant protein DUterus-1.710.013
204CEP55centrosomal protein 55kDaUterus+1.710.001
205NUP210nucleoporin 210kDaUterus+1.710.001
206ZBED2zinc finger, BED-type containing 2Uterus-1.710.001
207PRSS2protease, serine, 2 (trypsin 2)Uterus-1.710.007
208TP53I11tumor protein p53 inducible protein 11Uterus+1.710.018
209DPP4dipeptidyl-peptidase 4Uterus-1.700.004
210WNT5Awingless-type MMTV integration site family, member 5AUterus-1.690.044
211MCM7minichromosome maintenance complex component 7Uterus+1.690.000
212WDHD1WD repeat and HMG-box DNA binding protein 1Uterus+1.690.000
213PTGER4prostaglandin E receptor 4 (subtype EP4)Uterus-1.690.035
214BIRC5baculoviral IAP repeat containing 5Uterus+1.690.001
215TYMSthymidylate synthetaseUterus+1.690.009
216CDKN2Ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)Uterus+1.690.031
217RAD51AP1RAD51 associated protein 1Uterus+1.680.000
218TMEM194Atransmembrane protein 194AUterus+1.670.000
219ADAM8ADAM metallopeptidase domain 8Uterus+1.670.014
220DTYMKdeoxythymidylate kinase (thymidylate kinase)Uterus+1.670.000
221CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 5Uterus-1.660.038
222KIF1Ckinesin family member 1CUterus-1.660.002
223TTKTTK protein kinaseUterus+1.660.000
224MAGOHmago-nashi homolog, proliferation-associated (Drosophila)Uterus+1.660.024
225VSNL1visinin-like 1Uterus-1.650.025
226BTN2A1butyrophilin, subfamily 2, member A1Uterus+1.650.045
227GAS7growth arrest-specific 7Uterus-1.640.034
228CCNFcyclin FUterus+1.640.004
229RSRC1arginine/serine-rich coiled-coil 1Uterus+1.640.005
230DSG2desmoglein 2Uterus+1.640.004
231NDC80NDC80 kinetochore complex componentUterus+1.630.013
232CDC45cell division cycle 45Uterus+1.630.001
233PPM1Aprotein phosphatase, Mg2+/Mn2+ dependent, 1AUterus+1.630.005
234FGFBP1fibroblast growth factor binding protein 1Uterus-1.630.018
235ANKRD36ankyrin repeat domain 36Uterus+1.620.018
236ECI1enoyl-CoA delta isomerase 1Uterus+1.620.008
237SERPINI1serpin peptidase inhibitor, clade I (neuroserpin), member 1Uterus-1.610.011
238KCNK7potassium channel, subfamily K, member 7Uterus-1.610.003
239SLC16A1solute carrier family 16 (monocarboxylate transporter), member 1Uterus+1.610.047
240STAT1signal transducer and activator of transcription 1, 91kDaUterus+1.600.042
241DEGS1delta(4)-desaturase, sphingolipid 1Uterus-1.600.021
242HP1BP3heterochromatin protein 1, binding protein 3Uterus+1.600.019
243BRCA1breast cancer 1, early onsetUterus+1.600.005
244KLK12kallikrein-related peptidase 12Uterus-1.600.013
245GNG11guanine nucleotide binding protein (G protein), gamma 11Uterus-1.600.016
246HIST2H2AA3histone cluster 2, H2aa3Uterus+1.590.018
247GOLIM4golgi integral membrane protein 4Uterus+1.590.017
248KLF4Kruppel-like factor 4 (gut)Uterus-1.580.008
249ECHDC3enoyl CoA hydratase domain containing 3Uterus-1.580.026
250EPB41L4Aerythrocyte membrane protein band 4.1 like 4AUterus-1.580.009
251NEBLnebuletteUterus-1.580.050
252TGM2transglutaminase 2Uterus+1.570.015
253FEN1flap structure-specific endonuclease 1Uterus+1.570.000
254DEPTORDEP domain containing MTOR-interacting proteinUterus-1.570.017
255MARCKSL1MARCKS-like 1Uterus+1.560.005
256MKI67marker of proliferation Ki-67Uterus+1.550.009
257SIVA1SIVA1, apoptosis-inducing factorUterus+1.550.015
258PLSCR1phospholipid scramblase 1Uterus+1.540.019
259C2orf54chromosome 2 open reading frame 54Uterus-1.540.010
260SULT2B1sulfotransferase family, cytosolic, 2B, member 1Uterus-1.530.006
261CCNE2cyclin E2Uterus+1.530.014
262EFNA5ephrin-A5Uterus-1.530.011
263MIR22HGMIR22 host gene (non-protein coding)Uterus-1.530.015
264CELSR3cadherin, EGF LAG seven-pass G-type receptor 3Uterus+1.520.009
265CERS4ceramide synthase 4Uterus-1.520.040
266ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Uterus-1.510.033
267MAGEF1melanoma antigen family F, 1Uterus+1.510.019
268LMNB1lamin B1Uterus+1.510.004
269DCLK1doublecortin-like kinase 1Uterus-1.500.017
270HIGD1AHIG1 hypoxia inducible domain family, member 1AUterus-1.500.028
271MIS18BP1MIS18 binding protein 1Uterus+1.490.008
272APEX2APEX nuclease (apurinic/apyrimidinic endonuclease) 2Uterus+1.490.028
273STMN1stathmin 1Uterus+1.490.011
274GMNNgeminin, DNA replication inhibitorUterus+1.490.004
275SERPINB1serpin peptidase inhibitor, clade B (ovalbumin), member 1Uterus-1.490.023
276CKS2CDC28 protein kinase regulatory subunit 2Uterus+1.490.016
277UPF3BUPF3 regulator of nonsense transcripts homolog B (yeast)Uterus+1.480.015
278HSPBAP1HSPB (heat shock 27kDa) associated protein 1Uterus+1.480.010
279TACC3transforming, acidic coiled-coil containing protein 3Uterus+1.480.020
280POLQpolymerase (DNA directed), thetaUterus+1.480.003
281ME1malic enzyme 1, NADP(+)-dependent, cytosolicUterus-1.480.036
282KRT2keratin 2Uterus-1.480.004
283MGLLmonoglyceride lipaseUterus-1.480.003
284ACPPacid phosphatase, prostateUterus-1.470.024
285EVPLenvoplakinUterus-1.470.011
286MPHOSPH9M-phase phosphoprotein 9Uterus+1.470.048
287PDLIM2PDZ and LIM domain 2 (mystique)Uterus-1.470.007
288POLA1polymerase (DNA directed), alpha 1, catalytic subunitUterus+1.460.005
289SPINK2serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)Uterus-1.460.023
290S100A14S100 calcium binding protein A14Uterus-1.460.044
291CDC25Acell division cycle 25AUterus+1.460.029
292H2BFSH2B histone family, member S (pseudogene)Uterus+1.460.006
293U2SURPU2 snRNP-associated SURP domain containingUterus+1.450.005
294CDC20cell division cycle 20Uterus+1.440.023
295TFDP2transcription factor Dp-2 (E2F dimerization partner 2)Uterus+1.440.036
296ATP13A3ATPase type 13A3Uterus+1.440.010
297LDLRlow density lipoprotein receptorUterus+1.440.050
298SLC16A3solute carrier family 16 (monocarboxylate transporter), member 3Uterus+1.440.046
299FANCAFanconi anemia, complementation group AUterus+1.430.005
300RPP25ribonuclease P/MRP 25kDa subunitUterus+1.430.010
301KANK1KN motif and ankyrin repeat domains 1Uterus-1.430.010
302SLC25A36solute carrier family 25 (pyrimidine nucleotide carrier ), member 36Uterus+1.430.010
303TOPBP1topoisomerase (DNA) II binding protein 1Uterus+1.430.007
304KIF23kinesin family member 23Uterus+1.420.045
305ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3Uterus-1.420.003
306NCAPGnon-SMC condensin I complex, subunit GUterus+1.420.021
307MCM6minichromosome maintenance complex component 6Uterus+1.410.003
308PLK4polo-like kinase 4Uterus+1.410.015
309EZH2enhancer of zeste homolog 2 (Drosophila)Uterus+1.410.014
310TFRCtransferrin receptorUterus+1.400.023
311LAPTM4Blysosomal protein transmembrane 4 betaUterus+1.400.044
312LIMK1LIM domain kinase 1Uterus+1.400.022
313HLTFhelicase-like transcription factorUterus+1.400.018
314DNMT1DNA (cytosine-5-)-methyltransferase 1Uterus+1.400.003
315PITPNAphosphatidylinositol transfer protein, alphaUterus-1.400.014
316ACYP1acylphosphatase 1, erythrocyte (common) typeUterus+1.390.039
317PEG3paternally expressed 3Uterus-1.390.041
318KIF20Bkinesin family member 20BUterus+1.390.017
319ZNF668zinc finger protein 668Uterus+1.390.022
320RMI1RecQ mediated genome instability 1Uterus+1.380.039
321HMGB2high mobility group box 2Uterus+1.380.012
322LANCL1LanC lantibiotic synthetase component C-like 1 (bacterial)Uterus-1.380.045
323TPP1tripeptidyl peptidase IUterus+1.380.033
324KIF14kinesin family member 14Uterus+1.360.011
325KIF18Bkinesin family member 18BUterus+1.360.006
326FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideUterus-1.360.017
327GULP1GULP, engulfment adaptor PTB domain containing 1Uterus-1.360.048
328GFOD2glucose-fructose oxidoreductase domain containing 2Uterus-1.360.049
329CENPMcentromere protein MUterus+1.360.034
330ITGB4integrin, beta 4Uterus+1.350.031
331VRK1vaccinia related kinase 1Uterus+1.350.029
332RANBP3RAN binding protein 3Uterus+1.350.035
333RAD51RAD51 recombinaseUterus+1.340.027
334PARP2poly (ADP-ribose) polymerase 2Uterus+1.340.022
335PSMC3IPPSMC3 interacting proteinUterus+1.320.023
336MADCAM1mucosal vascular addressin cell adhesion molecule 1Uterus-1.320.021
337TIMELESStimeless circadian clockUterus+1.270.016
338MTF2metal response element binding transcription factor 2Uterus+1.250.048
339MBD4methyl-CpG binding domain protein 4Uterus+1.250.018

Expression patterns in normal tissues for genes affiliated with Cervical Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Squamous Cell Carcinoma.

Pathways for genes affiliated with Cervical Squamous Cell Carcinoma

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Pathways related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6KRT14, KRT8
2
Show member pathways
9.5MMP14, TIMP2
3
Show member pathways
Signaling Pathways in Glioblastoma37
9.1RASSF1, TYMP, DAPK1

Compounds for genes affiliated with Cervical Squamous Cell Carcinoma

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Compounds related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1calcipotriol44 60 29 1212.9KRT14, KRT10
2ethylenediaminetetraacetic acid449.7MMP14, TIMP2
3cytochalasin449.7MMP14, TIMP2
4hematoxylin449.7KRT8, KRT10, KRT14
5sodium bisulfite449.6RASSF1, DAPK1
65-methylcytosine44 2510.6RASSF1, DAPK1
7p00001449.6MMP14, TIMP2, TYMP
8cytosine44 2510.5KRT14, RASSF1, TYMP
9crcs449.5DAPK1, TYMP, RASSF1
10herbimycin a44 6010.4TIMP2, MMP14, CD40
11bromodeoxyuridine449.4KRT14, KRT10, KRT8, MMP14
12retinoid449.3KRT14, KRT10, KRT8
13glyceraldehyde 3-phosphate449.2TYMP, TIMP2, MMP14, KRT10
14methotrexate50 44 1211.2CD40, TIMP2, TYMP
1512-o-tetradecanoylphorbol 13-acetate449.2CD40, MMP14, TIMP2, TYMP
16ly294002449.1TYMP, TIMP2, MMP14, CD40
17thymidine44 2510.1CD40, MMP14, TIMP2, TYMP
18matrigel449.1TYMP, TIMP2, MMP14, KRT8
19paclitaxel44 50 1211.1CD40, KRT8, TIMP2, TYMP
20o6-methylguanine449.0DAPK1, TP73, RASSF1
21tamoxifen44 50 29 1212.0KRT14, KRT8, TIMP2, TYMP
22creatinine449.0TYMP, TIMP2, KRT8, CD40
23butyrate449.0TIMP2, KRT8, KRT14, CD40
24genistein44 29 60 3 25 1214.0TIMP2, MMP14, KRT8, CD40
25chloramphenicol44 3 50 1211.9CD40, KRT14, MMP14, TP73
26cholesterol44 29 25 1211.9TIMP2, MMP14, KRT14, CD40
27doxorubicin44 50 1210.9CD40, KRT8, TP73, TYMP
28agar448.8KRT8, RASSF1, MMP14
29steroid448.8TIMP2, KRT8, KRT10, CD40
30azathioprine44 3 50 1211.8TP73, TIMP2, RASSF1
31p002448.8TYMP, TP73, TIMP2, MMP14
32cycloheximide448.7CD40, KRT8, MMP14, TIMP2, TYMP
335fluorouracil448.6TYMP, TP73, TIMP2
345-aza-2deoxycytidine448.4DAPK1, TP73, TIMP2, RASSF1
35cisplatin44 50 60 1211.4KRT14, KRT8, RASSF1, TP73, TYMP
36glucose448.4TYMP, TIMP2, MMP14, KRT8, KRT14, CD40
37p003448.3TYMP, TP73, TIMP2, RASSF1, CD40
38cysteine448.1TYMP, TIMP2, SERPINB3, MMP14, KRT8, KRT14
39actinomycin d448.0TYMP, TP73, TIMP2, MMP14, KRT8, CD40
40vegf448.0TYMP, TP73, TIMP2, MMP14, KRT8, CD40
41lipid447.8TP73, TIMP2, MMP14, KRT8, KRT14, CD40
42calcium44 50 25 1210.8DAPK1, TIMP2, MMP14, KRT8, KRT10, KRT14
43oligonucleotide447.8TP73, TIMP2, MMP14, RASSF1, KRT8, CD40
44paraffin447.3CD40, TYMP, TP73, TIMP2, MMP14, KRT8
45progesterone44 29 60 25 1211.3TYMP, TP73, TIMP2, MMP14, KRT8, KRT10
46tyrosine447.3TYMP, TP73, TIMP2, MMP14, KRT8, KRT10
47threonine447.2DAPK1, TP73, MMP14, RASSF1, KRT8, KRT10
48retinoic acid44 257.9DAPK1, TP73, TIMP2, RASSF1, KRT8, KRT10
49serine446.8DAPK1, TYMP, TIMP2, SERPINB3, MMP14, RASSF1
50estrogen446.6DAPK1, TYMP, TP73, TIMP2, MMP14, RASSF1

GO Terms for genes affiliated with Cervical Squamous Cell Carcinoma

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Cellular components related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.3KRT14, KRT10, KRT8
2intermediate filamentGO:0058829.2KRT8, KRT10, KRT14
3extracellular spaceGO:0056158.9CD40, KRT10, SERPINB3, TIMP2
4extracellular vesicular exosomeGO:0700628.4SERPINB3, KRT8, KRT10, KRT14, CD40
5cytoplasmGO:0057377.3CD40, DAPK1, SERPINB3, MMP14, RASSF1, KRT8

Biological processes related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of proteolysisGO:0458619.6SERPINB3, TIMP2

Molecular functions related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4CD40, KRT14, KRT8, RASSF1, MMP14, TIMP2

Products for genes affiliated with Cervical Squamous Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Cervical Squamous Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet