MCID: CRV038
MIFTS: 54

Cervical Squamous Cell Carcinoma malady

Cancer diseases category

Summaries for Cervical Squamous Cell Carcinoma

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MalaCards: Cervical Squamous Cell Carcinoma, also known as squamous cell carcinoma of the cervix uteri, is related to squamous cell carcinoma and cervical cancer. An important gene associated with Cervical Squamous Cell Carcinoma is SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3), and among its related pathways are Pathways in cancer and MicroRNAs in cancer. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and tongue, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Cervical Squamous Cell Carcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical squamous cell carcinoma 8 10 44 60
squamous cell carcinoma of the cervix uteri 8
squamous cell carcinoma of cervix 8


External Ids:

Disease Ontology8 DOID:3744
SNOMED-CT56 254886006
NCIt39 C4028

Related Diseases for Cervical Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Cervical Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma32.0TP73, SERPINB3, DAPK1, MKI67
2cervical cancer30.9TP63, SERPINB3, KRT8, KRT10, RASSF1, SKP2
3adenocarcinoma30.8TP73, TP63, CEACAM5, SERPINB3, KRT8, KRT10
4cervical adenocarcinoma30.8CEACAM5, KRT8, RASSF1, CDKN1B, CDKN2A
5keratoacanthoma30.5KRT10, MKI67, IVL, MLH1
6endometrial carcinoma30.5TP73, RASSF1, CDKN2A, TYMP, MLH1, TIMP2
7neuroendocrine carcinoma30.5TP63, CEACAM5, KRT8
8sarcoma30.4TP63, KRT8, MKI67, MLH1
9breast cancer30.3TP73, TP63, CEACAM5, KRT8, KRT14, RASSF1
10papilloma30.3TP73, TP63, KRT10, KRT14, RASSF1, CDKN1B
11cervical intraepithelial neoplasia30.3TP73, KRT8, KRT10, CDKN2A, MKI67, IVL
12cervicitis11.4
13small cell carcinoma10.4
14ovarian squamous cell carcinoma10.4
15microinvasive cervical squamous cell carcinoma10.4
16cardiac tamponade10.3
17endometrial squamous cell carcinoma10.3
18endometrial adenocarcinoma10.3
19in situ carcinoma10.3
20fibrous histiocytoma10.3
21anal carcinoma in situ10.3
22keratinizing squamous cell carcinoma10.3
23cervical keratinizing squamous cell carcinoma10.3
24anal squamous cell carcinoma10.3
25breast sarcoma10.3
26histiocytoma10.3
27squamous cell papilloma10.2
28endocervical carcinoma10.2
29endocervicitis10.2
30cervix small cell carcinoma10.2
31uterine carcinosarcoma10.2
32adrenal carcinoma10.2
33breast adenocarcinoma10.2
34breast squamous cell carcinoma10.2
35cell type cancer10.2
36cervical carcinosarcoma10.2
37dermatomyositis10.2
38lung squamous cell carcinoma10.2
39skin squamous cell carcinoma10.2
40vaginitis10.2
41rare squamous cell carcinoma of the cervix uteri10.2
42hepatocellular carcinoma10.0TP73, CEACAM5, SERPINB3, KRT8, KRT14, RASSF1
43retinoblastoma10.0TP73, KRT10, KRT14, RASSF1, SKP2, CDKN1B
44squamous cell carcinoma of the head and neck10.0TP73, TP63, KRT14, RASSF1, MMP14, CXCL14
45oral cancer10.0TP73, SERPINB3, KRT14, SKP2, CDKN1B, CDKN2A
46lung adenocarcinoma10.0TP73, TP63, CEACAM5, KRT8, RASSF1, SKP2
47kidney cancer10.0TP73, KRT8, KRT14, RASSF1, DAPK1, CDKN1B
48ovarian cancer10.0TP73, CEACAM5, RASSF1, SKP2, MMP14, CDKN1B
49colorectal cancer10.0TP73, CEACAM5, KRT8, KRT14, RASSF1, DAPK1
50melanoma10.0TP73, TP63, KRT8, KRT14, RASSF1, SKP2

Graphical network of the top 20 diseases related to Cervical Squamous Cell Carcinoma:



Diseases related to cervical squamous cell carcinoma

Clinical Features for Cervical Squamous Cell Carcinoma

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Drugs & Therapeutics for Cervical Squamous Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Cervical Squamous Cell Carcinoma

Search NIH Clinical Center for Cervical Squamous Cell Carcinoma

Search CenterWatch for Cervical Squamous Cell Carcinoma

Genetic Tests for Cervical Squamous Cell Carcinoma

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Anatomical Context for Cervical Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Cervical Squamous Cell Carcinoma:

32
Cervix, Lymph node, Tongue, Skin, Ovary, Placenta, Testes, T cells, Breast, Lung, Endothelial, Testis

Animal Models for Cervical Squamous Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cervical Squamous Cell Carcinoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8CDKN2A, TP63, KRT8, KRT10, KRT14, RASSF1
2MP:000537610.7CXCL14, CD40, MMP14, KRT14, DAPK1
3MP:000200610.7CDKN2A, MLH1, TP73, TP63, KRT10, RASSF1
4MP:000538410.7SKP2, TP63, TP73, KRT14, RASSF1, MMP14
5MP:000538910.7MLH1, CDKN2A, CDKN1B, CXCL14, SKP2, TP73
6MP:000538110.6TP73, CDKN2A, CDKN1B, MLH1, MMP14, KRT14
7MP:000536710.6MMP14, CXCL14
8MP:001076810.5KRT14, MMP14, CXCL14, KRT10, CDKN1B, TP73
9MP:000539710.5CXCL14, CDKN1B, CD40, CDKN2A, TIMP2, KRT8
10MP:000537910.4MLH1, CDKN2A, CDKN1B, SKP2, TP73
11MP:001077110.2MMP14, CDKN2A, CDKN1B, KRT14

Publications for Cervical Squamous Cell Carcinoma

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50PubMed
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Articles related to Cervical Squamous Cell Carcinoma:

(show top 50)    (show all 347)
idTitleAuthorsYear
1
Usefulness of 3.0Tesla diffusion-weighted MRI for discrimination of reactive and metastatic cervical lymph nodes in patients with oral squamous cell carcinoma: a pilot study. (24408820)
2014
2
Advanced composite of large cell neuroendocrine carcinoma and squamous cell carcinoma: a case report of uterine cervical cancer in a virgin woman. (24062959)
2013
3
Cervical lymph node metastasis in oral squamous cell carcinoma: A correlative study between histopathological malignancy grading and lymph node metastasis. (24355962)
2013
4
Genetic variants in interleukin-18 gene and risk for cervical squamous cell carcinoma. (23603311)
2013
5
Immune response in cervical lymph nodes from patients with primary oral squamous cell carcinoma. (23278174)
2013
6
Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma. (23483249)
2013
7
A population-based study of selected demographic characteristics of Israeli-Jewish women with cervical squamous cell carcinoma. (20623130)
2011
8
Polymorphism of HLA-DRB1 and -DQB1 alleles among young women with cervical squamous cell carcinoma and its relation with human papillomavirus type 16 infection]. (21029659)
2010
9
Use of serum squamous cell carcinoma antigen for follow-up monitoring of cervical cancer patients who were treated by concurrent chemoradiotherapy. (20840788)
2010
10
HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women. (20501960)
2010
11
Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma. (19638983)
2009
12
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. (19217043)
2009
13
Human papillomavirus DNA and e6/e7 mRNA status in relation to survival of patients treated for cervical squamous cell carcinoma. (19440467)
2008
14
Expression of p53, bcl-2 and Ki-67 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. (18561741)
2008
15
Molecular diagnosis of sentinel lymph node metastases in cervical cancer using squamous cell carcinoma antigen. (18765550)
2008
16
Chromosomal gain of 3q and loss of 11q often associated with nodal metastasis in early stage cervical squamous cell carcinoma. (18063510)
2007
17
Radiation reduces carboplatin sensitivity and enhances nedaplatin sensitivity in cervical squamous cell carcinoma in vitro. (17966212)
2007
18
The prognostic significance of human epidermal growth factor receptor correlations in squamous cell cervical carcinoma. (17465227)
2007
19
Gene expression profiles in squamous cell cervical carcinoma using array-based comparative genomic hybridization analysis. (17504382)
2007
20
Secondary small cell neuroendocrine carcinoma of the cervix after radiotherapy for cervical squamous cell carcinoma. (17884059)
2007
21
Expression of angiotensin II type 1 receptor in cervical squamous cell carcinoma and its clinical significance]. (17892132)
2007
22
Early determination of uterine cervical squamous cell carcinoma radioresponse identifies high- and low-response tumors. (16343805)
2006
23
Expression and clinical significance of autophagy gene Beclin 1 in cervical squamous cell carcinoma]. (17236580)
2006
24
HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and meta-analysis. (16720214)
2006
25
Effective chemoradiotherapy protocol with 5-fluorouracil for cervical squamous cell carcinoma in vitro. (16800250)
2006
26
Tumor lymphangiogenesis in cervical squamous cell carcinoma and its clinical significance]. (16179117)
2005
27
Cell proliferation of bulky cervical squamous cell carcinoma is strongly associated with a paracrine tissue-specific growth factor(s). (16211274)
2005
28
Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma. (15870923)
2005
29
Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000. (14983500)
2004
30
Utility of mean nuclear volume in predicting disease-free survival in locally advanced invasive cervical squamous cell carcinoma. (15457676)
2004
31
Expression of cancer/testis tumor associated antigens in cervical squamous cell carcinoma. (12759544)
2003
32
Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced, unresectable, nonmetastatic squamous cell carcinoma of the head and neck. (11710599)
2001
33
Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma. (11150108)
2001
34
Expression of p27 and p53 in cervical squamous cell carcinoma patients treated with radiotherapy alone: radiotherapeutic effect and prognosis. (10870059)
2000
35
Correlations between serum progesterone and smoking, and the growth fraction of cervical squamous cell carcinoma. (11268431)
2000
36
Clinical relevance of HPV 16/18 testing methods in cervical squamous cell carcinoma. (11127922)
2000
37
CD44 expression in uterine cervical intraepithelial neoplasia and squamous cell carcinoma: an immunohistochemical study. (9476059)
1998
38
Placenta growth factor is abundantly expressed in human cervical squamous cell carcinoma. (9443023)
1997
39
Analysis of response to radiation therapy of patients with cervical adenocarcinoma compared with squamous cell carcinoma. MIB-1 and PC10 labeling indices. (8635096)
1996
40
Bilateral primary ovarian squamous cell carcinoma associated with human papilloma virus infection and vulvar and cervical intraepithelial neoplasia. A case report with review of the literature. (8651358)
1996
41
Clinical value of pretreatment serum Cyfra 21-1, tissue polypeptide antigen, and squamous cell carcinoma antigen levels in patients with cervical cancer. (8625184)
1995
42
Implications of human papillomavirus type for survival in cervical squamous cell carcinoma. (11578501)
1995
43
Fine needle aspiration cytodiagnosis of basaloid-squamous cell carcinoma metastatic to a cervical lymph node. (8249523)
1993
44
Evaluation of carcinoembryonic antigen, tissue polypeptide antigen, and squamous cell carcinoma antigen in the detection of cervical cancers. (1326391)
1992
45
Squamous cell carcinoma antigen and carcinoembryonic antigen levels as prognostic factors for the response of cervical carcinoma to chemotherapy. (2191907)
1990
46
An evaluation of squamous cell carcinoma antigen in patients with cervical squamous cell carcinoma. (3475982)
1987
47
Keratoacanthomas associated with cervical squamous cell carcinoma. (4004294)
1985
48
Right ventricular metastasis of cervical squamous cell carcinoma. (6496298)
1984
49
Tumor antigen of human cervical squamous cell carcinoma: correlation of circulating levels with disease progress. (421183)
1979
50
Radioimmunoassay for tumor-antigen of human cervical squamous cell carcinoma. (533610)
1979

Genetic Variations for Cervical Squamous Cell Carcinoma

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Expression for genes affiliated with Cervical Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Squamous Cell Carcinoma.

Pathways for genes affiliated with Cervical Squamous Cell Carcinoma

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29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Cervical Squamous Cell Carcinoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.0SKP2, KRT14, KRT10, KRT8, CEACAM5, TP63
2paraffin4411.0MLH1, IVL, MKI67, TYMP, CDKN2A, CD40
3retinoic acid44 2412.0SKP2, DAPK1, KRT10, KRT8, TP63, TP73
4serine4411.0DAPK1, TIMP2, CDKN2A, CD40, MMP14, TYMP
5p0034411.0TP73, TP63, CEACAM5, RASSF1, CDKN1B, CD40
6threonine4411.0DAPK1, MKI67, TP73, KRT8, KRT10, KRT14
7vegf4411.0CDKN2A, MMP14, CDKN1B, CD40, TYMP, MKI67
8bromodeoxyuridine4411.0KRT14, TP63, KRT8, KRT10, MKI67, IVL
9cisplatin44 49 59 1114.0KRT8, CEACAM5, TP63, TP73, KRT14, CDKN2A
10tyrosine4410.9TYMP, MKI67, TP63, CEACAM5, KRT8, KRT10
11p000014410.9MLH1, MKI67, TYMP, CDKN2A, CDKN1B, MMP14
12hematoxylin4410.9TP63, CEACAM5, KRT8, KRT10, KRT14, CDKN2A
13doxorubicin44 49 1112.9CDKN1B, KRT8, MLH1, CEACAM5, CD40, TYMP
14p0024410.9TP73, CEACAM5, TIMP2, MLH1, MKI67, TYMP
15thymidine44 2411.9MKI67, TYMP, CD40, CDKN1B, TP63, MMP14
165fluorouracil4410.9CDKN2A, TIMP2, MLH1, IVL, MKI67, TYMP
17estrogen4410.9IVL
18oligonucleotide4410.9TIMP2, TP73, KRT8, RASSF1, SKP2, MMP14
19crcs4410.9RASSF1, CDKN2A, TYMP, MLH1, DAPK1, CEACAM5
20glucose4410.9TYMP, CDKN2A, IVL, KRT8, TIMP2, CDKN1B
21actinomycin d4410.9KRT8, TYMP, TP73, MMP14, CDKN1B, CD40
22steroid4410.9MKI67, CDKN2A, CD40, KRT10, KRT8
23paclitaxel44 49 1112.9TIMP2, TYMP, KRT8, CDKN2A, CDKN1B, MLH1
24cysteine4410.9SERPINB3, TIMP2, IVL, TYMP, CDKN2A, MMP14
25butyrate4410.9CD40
26o6-methylguanine4410.9MLH1, CDKN2A, DAPK1, RASSF1, TP73
27calcium44 49 11 2413.9TIMP2, DAPK1, MMP14, KRT14, KRT10, KRT8
28methotrexate44 49 1112.9CD40, TYMP, MKI67, IVL, TIMP2, CDKN2A
29cytosine44 2411.9MLH1, KRT14, CEACAM5, TYMP, CDKN2A, RASSF1
30sodium bisulfite4410.8RASSF1, DAPK1, CDKN2A, MLH1
315-aza-2deoxycytidine4410.8DAPK1, RASSF1, TP73, TIMP2, MLH1, CDKN2A
32cycloheximide4410.8KRT8, TYMP
33lipid4410.8IVL, KRT14, CEACAM5, TP73, MMP14, CD40
345-methylcytosine44 2411.8MLH1, RASSF1, DAPK1, CDKN2A
35oxygen44 2411.8CDKN2A, IVL, CD40, TYMP, MKI67, MLH1
36cholesterol44 28 11 2413.8TIMP2, IVL, CDKN2A, CD40, CDKN1B, MMP14
37irinotecan44 49 1112.8MKI67, MLH1, TYMP, CDKN2A, CEACAM5
38chloramphenicol44 2 1112.8KRT14, MMP14, CD40, IVL, CDKN2A, TP73
39agar4410.8MMP14, KRT8, CEACAM5, CDKN1B, CDKN2A, RASSF1
40fatty acid4410.7CDKN2A, CDKN1B, KRT10, TP73, IVL, MLH1
41mitomycin c4410.7CEACAM5, MKI67, TYMP, CD40, TP63
42azathioprine44 49 2 1113.7MLH1, TP73, RASSF1, TIMP2, CDKN2A
43arginine4410.7MLH1, MKI67, CDKN2A, CDKN1B, KRT14, KRT10
4412-o-tetradecanoylphorbol 13-acetate4410.7CDKN1B, TIMP2, IVL, TYMP, CD40, MMP14
45tamoxifen44 49 28 1113.6KRT14, TIMP2, MKI67, TYMP, KRT8, CDKN1B
46ly2940024410.6CD40, SKP2, MMP14, CDKN1B, TYMP, TIMP2
47glyceraldehyde 3-phosphate4410.5CEACAM5, KRT10, MMP14, TYMP, TIMP2
48folate4410.5RASSF1, TYMP, MLH1, MKI67, CDKN2A
49genistein44 28 59 2 11 2415.4CDKN2A, CDKN1B, CD40, MMP14, TIMP2, KRT8
50proline4410.2IVL, MKI67, KRT14, TP73, KRT10, MLH1

GO Terms for genes affiliated with Cervical Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.5KRT8, KRT10, KRT14
2cytoplasmGO:00573710.4TP63, IVL, MKI67, CDKN2A, CDKN1B, DAPK1
3keratin filamentGO:04509510.2KRT14, KRT10, KRT8

Biological processes related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell cycle arrestGO:00705010.5TP73, RASSF1, CDKN1B, CDKN2A
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5TP73, TP63
3keratinocyte differentiationGO:03021610.4IVL, KRT10, TP63
4mitotic G1 DNA damage checkpointGO:03157110.2TP73, TP63

Molecular functions related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.5DAPK1, SKP2, RASSF1, CEACAM5, TP63, TP73
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.5CDKN2A, CDKN1B
3p53 bindingGO:00203910.4TP73, TP63, CDKN2A
4protein bindingGO:00551510.2KRT8, TP73, MLH1, MKI67, CDKN2A, CD40

Products for genes affiliated with Cervical Squamous Cell Carcinoma

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Sources for Cervical Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet