MCID: CRV038
MIFTS: 54

Cervical Squamous Cell Carcinoma malady

Cancer diseases category

Summaries for Cervical Squamous Cell Carcinoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Cervical Squamous Cell Carcinoma, also known as squamous cell carcinoma of the cervix uteri, is related to squamous cell carcinoma and cervical cancer. An important gene associated with Cervical Squamous Cell Carcinoma is SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3), and among its related pathways are Pathways in cancer and MicroRNAs in cancer. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and tongue, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Cervical Squamous Cell Carcinoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cervical squamous cell carcinoma 8 10 44 60
squamous cell carcinoma of the cervix uteri 8
squamous cell carcinoma of cervix 8


External Ids:

Disease Ontology8 DOID:3744
SNOMED-CT56 254886006
NCIt39 C4028

Related Diseases for Cervical Squamous Cell Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cervical Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma32.0TP73, SERPINB3, DAPK1, MKI67
2cervical cancer30.9TP63, SERPINB3, KRT8, KRT10, RASSF1, SKP2
3adenocarcinoma30.8TP73, TP63, CEACAM5, SERPINB3, KRT8, KRT10
4cervical adenocarcinoma30.8CEACAM5, KRT8, RASSF1, CDKN1B, CDKN2A
5keratoacanthoma30.5KRT10, MKI67, IVL, MLH1
6endometrial carcinoma30.5TP73, RASSF1, CDKN2A, TYMP, MLH1, TIMP2
7neuroendocrine carcinoma30.5TP63, CEACAM5, KRT8
8sarcoma30.4TP63, KRT8, MKI67, MLH1
9breast cancer30.3TP73, TP63, CEACAM5, KRT8, KRT14, RASSF1
10papilloma30.3TP73, TP63, KRT10, KRT14, RASSF1, CDKN1B
11cervical intraepithelial neoplasia30.3TP73, KRT8, KRT10, CDKN2A, MKI67, IVL
12cervicitis11.4
13small cell carcinoma10.4
14ovarian squamous cell carcinoma10.4
15microinvasive cervical squamous cell carcinoma10.4
16cardiac tamponade10.3
17endometrial squamous cell carcinoma10.3
18endometrial adenocarcinoma10.3
19in situ carcinoma10.3
20fibrous histiocytoma10.3
21anal carcinoma in situ10.3
22keratinizing squamous cell carcinoma10.3
23cervical keratinizing squamous cell carcinoma10.3
24anal squamous cell carcinoma10.3
25breast sarcoma10.3
26histiocytoma10.3
27squamous cell papilloma10.2
28endocervical carcinoma10.2
29endocervicitis10.2
30cervix small cell carcinoma10.2
31uterine carcinosarcoma10.2
32adrenal carcinoma10.2
33breast adenocarcinoma10.2
34breast squamous cell carcinoma10.2
35cell type cancer10.2
36cervical carcinosarcoma10.2
37dermatomyositis10.2
38lung squamous cell carcinoma10.2
39skin squamous cell carcinoma10.2
40vaginitis10.2
41rare squamous cell carcinoma of the cervix uteri10.2
42hepatocellular carcinoma10.0TP73, CEACAM5, SERPINB3, KRT8, KRT14, RASSF1
43retinoblastoma10.0TP73, KRT10, KRT14, RASSF1, SKP2, CDKN1B
44squamous cell carcinoma of the head and neck10.0TP73, TP63, KRT14, RASSF1, MMP14, CXCL14
45oral cancer10.0TP73, SERPINB3, KRT14, SKP2, CDKN1B, CDKN2A
46lung adenocarcinoma10.0TP73, TP63, CEACAM5, KRT8, RASSF1, SKP2
47kidney cancer10.0TP73, KRT8, KRT14, RASSF1, DAPK1, CDKN1B
48ovarian cancer10.0TP73, CEACAM5, RASSF1, SKP2, MMP14, CDKN1B
49colorectal cancer10.0TP73, CEACAM5, KRT8, KRT14, RASSF1, DAPK1
50melanoma10.0TP73, TP63, KRT8, KRT14, RASSF1, SKP2

Graphical network of the top 20 diseases related to Cervical Squamous Cell Carcinoma:



Diseases related to cervical squamous cell carcinoma

Clinical Features for Cervical Squamous Cell Carcinoma

About this section

Drugs & Therapeutics for Cervical Squamous Cell Carcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cervical Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Cervical Squamous Cell Carcinoma

Search NIH Clinical Center for Cervical Squamous Cell Carcinoma

Search CenterWatch for Cervical Squamous Cell Carcinoma

Genetic Tests for Cervical Squamous Cell Carcinoma

About this section

Anatomical Context for Cervical Squamous Cell Carcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Cervical Squamous Cell Carcinoma:

32
Cervix, Lymph node, Tongue, Skin, Ovary, Placenta, Testes, T cells, Breast, Lung, Endothelial, Testis

Animal Models for Cervical Squamous Cell Carcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Cervical Squamous Cell Carcinoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8TP73, TIMP2, TYMP, CDKN2A, CD40, CDKN1B
2MP:000537610.7CD40, CXCL14, DAPK1, MMP14, KRT14
3MP:000200610.7MLH1, CDKN2A, CDKN1B, RASSF1, KRT14, KRT10
4MP:000538410.7CDKN1B, CD40, CDKN2A, TYMP, MLH1, DAPK1
5MP:000538910.7MLH1, CDKN2A, CDKN1B, CXCL14, MMP14, SKP2
6MP:000538110.6MLH1, CDKN2A, CDKN1B, MMP14, KRT14, KRT8
7MP:000536710.6CXCL14, MMP14
8MP:001076810.5MLH1, CDKN2A, CDKN1B, CXCL14, MMP14, RASSF1
9MP:000539710.5CDKN2A, CD40, CDKN1B, CXCL14, SKP2, KRT8
10MP:000537910.4MLH1, CDKN2A, CDKN1B, SKP2, TP73
11MP:001077110.2CDKN2A, CDKN1B, MMP14, KRT14

Publications for Cervical Squamous Cell Carcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Cervical Squamous Cell Carcinoma:

(show top 50)    (show all 347)
idTitleAuthorsYear
1
Pre-operative contrast enhanced computer tomographic evaluation of cervical nodal metastatic disease in oral squamous cell carcinoma. (24369206)
2013
2
Is conization once following by simple hysterectomy sufficient for all clinical stage IA1 cervical squamous cell carcinoma? (24075378)
2013
3
HPV genotypes in paraffin sections of non-cervical squamous cell carcinoma in Qingdao of China. (23599766)
2013
4
Immunohistochemistry, a valuable tool in detection of cervical lymph node micrometastases in head and neck squamous cell carcinoma: a prospective study. (24427623)
2013
5
Expression and clinical significance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer. (24247658)
2013
6
ERCC1 mRNA levels can predict the response to cisplatin-based concurrent chemoradiotherapy of locally advanced cervical squamous cell carcinoma. (23259415)
2012
7
The poorer survival of patients with cervical adenocarcinoma and adenosquamous cell carcinoma compared to those with squamous cell carcinoma might be improved by a different treatment. (22735787)
2012
8
Direct skin involvement of cervical lymph node metastasis from mucosal squamous cell carcinoma of the head and neck. (23217250)
2012
9
Biological and clinical significance of NAC1 expression in cervical carcinomas: a comparative study between squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas. (21889186)
2012
10
Annexin A5 protein expression is associated with the histological differentiation of uterine cervical squamous cell carcinoma in patients with an increased serum concentration. (22971941)
2012
11
Expression of PSCA, PIWIL1 and TBX2 and its correlation with HPV16 infection in formalin-fixed, paraffin-embedded cervical squamous cell carcinoma specimens. (20229117)
2010
12
Relationship between NFKB1 -94 insertion/deletion ATTG polymorphism and susceptibility of cervical squamous cell carcinoma risk. (19892748)
2010
13
Cyclooxygenase-2 expression in cervical squamous cell carcinoma: the significance of expression in neoplastic cells within the lymphovascular space. (20192574)
2009
14
Antitumor Effects of Camptothecin Combined with Conventional Anticancer Drugs on the Cervical and Uterine Squamous Cell Carcinoma Cell Line SiHa. (19885006)
2009
15
Usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung. (19369633)
2009
16
Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. (18097581)
2008
17
Regulatory T cells in a spectrum of HPV-induced cervical lesions: cervicitis, cervical intraepithelial neoplasia and squamous cell carcinoma. (18593438)
2008
18
Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with adverse clinical outcome. (17516585)
2007
19
Increased expression level of squamous cell carcinoma antigen 2 and 1 ratio is associated with poor prognosis in early-stage uterine cervical cancer. (17291250)
2007
20
Expression of E-cadherin in cervical lymph nodes from primary oral squamous cell carcinoma patients. (17331461)
2007
21
Different expression patterns of intact forms of squamous cell carcinoma antigens between normal and malignant cervical squamous epithelial tissues: nondenaturing polyacrylamide gel electrophoretic analysis. (16820922)
2006
22
Expression of PTEN in the progression of cervical neoplasia and its relation to tumor behavior and angiogenesis in invasive squamous cell carcinoma. (16482604)
2006
23
Inactivation of Crk SH3 domain-binding guanine nucleotide-releasing factor (C3G) in cervical squamous cell carcinoma. (16681758)
2006
24
Preoperative chemotherapy with irinotecan and mitomycin for FIGO stage IIIb cervical squamous cell carcinoma: a pilot study. (16398218)
2005
25
E1AF/PEA3 reduces the invasiveness of SiHa cervical cancer cells by activating serine proteinase inhibitor squamous cell carcinoma antigen. (15350549)
2004
26
Expression of transforming growth factor-beta1 in cervical squamous carcinoma cell and stroma]. (16137003)
2004
27
Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma. (15167830)
2004
28
Prognostic significance of Bax, Bcl-2, and p53 expressions in cervical squamous cell carcinoma treated by radiotherapy. (15350352)
2004
29
Study on the relationship between angiogenesis and cervical lymphatic metastasis in head and neck squamous cell carcinomas]. (12916359)
2003
30
Absence of point mutation in codons 12 and 13 of K-RAS oncogene in HPV-associated high grade dysplasia and squamous cell cervical carcinoma. (14557015)
2003
31
Retinoids, cisplatin and interferon-alpha in recurrent or metastatic cervical squamous cell carcinoma: clinical results of 2 phase II trials. (11956030)
2002
32
Inhibition of cervical lymph node metastasis by marimastat (BB-2516) in an orthotopic oral squamous cell carcinoma implantation model. (12405288)
2002
33
Chlamydia trachomatis and cervical squamous cell carcinoma. (11277820)
2001
34
Chlamydia trachomatis and cervical squamous cell carcinoma. (11277819)
2001
35
Effects of docetaxel in combination with radiation on human head and neck cancer cells (ZMK-1) and cervical squamous cell carcinoma cells (CaSki ). (11275989)
2001
36
Expression of bcl-2 and bax in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. (11198041)
2000
37
Platelet-derived endothelial cell growth factor expression and angiogenesis in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix. (11073333)
2000
38
Clinicopathological study of recurrent uterine cervical squamous-cell carcinoma. (10680336)
1999
39
Relative changes of MIB1 and PC10 labeling indexes in cell kinetics during radiotherapy for cervical squamous cell carcinoma. (9490095)
1997
40
Cervical squamous cell carcinoma and its precursor lesions: cytodiagnostic criteria and pitfalls. (9390926)
1996
41
MIB1 growth fraction is not related to prognosis in cervical squamous cell carcinoma treated with radiotherapy. (8852442)
1996
42
Recurrent cervical squamous cell carcinoma presenting with cardiac tamponade. (8838161)
1995
43
Intrinsic resistance of cervical squamous cell carcinoma cell lines to methotrexate (MTX) as a result of decreased accumulation of intracellular MTX polyglutamates. (7694891)
1993
44
In vitro platinum drug chemosensitivity of human cervical squamous cell carcinoma cell lines with intrinsic and acquired resistance to cisplatin. (8347478)
1993
45
Induction of human cervical squamous cell carcinoma by sequential transfection with human papillomavirus 16 DNA and viral Harvey ras. (2541388)
1989
46
Keratoacanthomas associated with cervical squamous cell carcinoma. (6691710)
1984
47
Histological and ultrastructural pattern of cervical squamous cell carcinoma in a young woman. (6822370)
1983
48
Current views on the condylomatous lesions in uterine cervix and their possible relationship to cervical squamous cell carcinoma. (6258114)
1980
49
Biological properties and radiation responses of the hamster uterine cervical squamous cell carcinoma. (441259)
1979
50
Decidual change in pelvic lymph nodes in the presence of cervical squamous cell carcinoma during pregnancy. (842598)
1977

Genetic Variations for Cervical Squamous Cell Carcinoma

About this section

Expression for genes affiliated with Cervical Squamous Cell Carcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cervical Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Squamous Cell Carcinoma.

Pathways for genes affiliated with Cervical Squamous Cell Carcinoma

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore, 51QIAGEN, 53Reactome
See all sources

Compounds for genes affiliated with Cervical Squamous Cell Carcinoma

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.0SKP2, KRT14, KRT10, KRT8, CEACAM5, TP63
2paraffin4411.0MLH1, IVL, MKI67, TYMP, CDKN2A, CD40
3retinoic acid44 2412.0SKP2, DAPK1, KRT10, KRT8, TP63, TP73
4serine4411.0DAPK1, TIMP2, CDKN2A, CD40, MMP14, TYMP
5p0034411.0TP73, TP63, CEACAM5, RASSF1, CDKN1B, CD40
6threonine4411.0DAPK1, MKI67, TP73, KRT8, KRT10, KRT14
7vegf4411.0CDKN2A, MMP14, CDKN1B, CD40, TYMP, MKI67
8bromodeoxyuridine4411.0KRT14, TP63, KRT8, KRT10, MKI67, IVL
9cisplatin44 49 59 1114.0KRT8, CEACAM5, TP63, TP73, KRT14, CDKN2A
10tyrosine4410.9TYMP, MKI67, TP63, CEACAM5, KRT8, KRT10
11p000014410.9MLH1, MKI67, TYMP, CDKN2A, CDKN1B, MMP14
12hematoxylin4410.9TP63, CEACAM5, KRT8, KRT10, KRT14, CDKN2A
13doxorubicin44 49 1112.9CDKN1B, KRT8, MLH1, CEACAM5, CD40, TYMP
14p0024410.9TP73, CEACAM5, TIMP2, MLH1, MKI67, TYMP
15thymidine44 2411.9MKI67, TYMP, CD40, CDKN1B, TP63, MMP14
165fluorouracil4410.9CDKN2A, TIMP2, MLH1, IVL, MKI67, TYMP
17estrogen4410.9IVL
18oligonucleotide4410.9TIMP2, TP73, KRT8, RASSF1, SKP2, MMP14
19crcs4410.9RASSF1, CDKN2A, TYMP, MLH1, DAPK1, CEACAM5
20glucose4410.9TYMP, CDKN2A, IVL, KRT8, TIMP2, CDKN1B
21actinomycin d4410.9KRT8, TYMP, TP73, MMP14, CDKN1B, CD40
22steroid4410.9MKI67, CDKN2A, CD40, KRT10, KRT8
23paclitaxel44 49 1112.9TIMP2, TYMP, KRT8, CDKN2A, CDKN1B, MLH1
24cysteine4410.9SERPINB3, TIMP2, IVL, TYMP, CDKN2A, MMP14
25butyrate4410.9CD40
26o6-methylguanine4410.9MLH1, CDKN2A, DAPK1, RASSF1, TP73
27calcium44 49 11 2413.9TIMP2, DAPK1, MMP14, KRT14, KRT10, KRT8
28methotrexate44 49 1112.9CD40, TYMP, MKI67, IVL, TIMP2, CDKN2A
29cytosine44 2411.9MLH1, KRT14, CEACAM5, TYMP, CDKN2A, RASSF1
30sodium bisulfite4410.8RASSF1, DAPK1, CDKN2A, MLH1
315-aza-2deoxycytidine4410.8DAPK1, RASSF1, TP73, TIMP2, MLH1, CDKN2A
32cycloheximide4410.8KRT8, TYMP
33lipid4410.8IVL, KRT14, CEACAM5, TP73, MMP14, CD40
345-methylcytosine44 2411.8MLH1, RASSF1, DAPK1, CDKN2A
35oxygen44 2411.8CDKN2A, IVL, CD40, TYMP, MKI67, MLH1
36cholesterol44 28 11 2413.8TIMP2, IVL, CDKN2A, CD40, CDKN1B, MMP14
37irinotecan44 49 1112.8MKI67, MLH1, TYMP, CDKN2A, CEACAM5
38chloramphenicol44 2 1112.8KRT14, MMP14, CD40, IVL, CDKN2A, TP73
39agar4410.8MMP14, KRT8, CEACAM5, CDKN1B, CDKN2A, RASSF1
40fatty acid4410.7CDKN2A, CDKN1B, KRT10, TP73, IVL, MLH1
41mitomycin c4410.7CEACAM5, MKI67, TYMP, CD40, TP63
42azathioprine44 49 2 1113.7MLH1, TP73, RASSF1, TIMP2, CDKN2A
43arginine4410.7MLH1, MKI67, CDKN2A, CDKN1B, KRT14, KRT10
4412-o-tetradecanoylphorbol 13-acetate4410.7CDKN1B, TIMP2, IVL, TYMP, CD40, MMP14
45tamoxifen44 49 28 1113.6KRT14, TIMP2, MKI67, TYMP, KRT8, CDKN1B
46ly2940024410.6CD40, SKP2, MMP14, CDKN1B, TYMP, TIMP2
47glyceraldehyde 3-phosphate4410.5CEACAM5, KRT10, MMP14, TYMP, TIMP2
48folate4410.5RASSF1, TYMP, MLH1, MKI67, CDKN2A
49genistein44 28 59 2 11 2415.4CDKN2A, CDKN1B, CD40, MMP14, TIMP2, KRT8
50proline4410.2IVL, MKI67, KRT14, TP73, KRT10, MLH1

GO Terms for genes affiliated with Cervical Squamous Cell Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.5KRT8, KRT10, KRT14
2cytoplasmGO:00573710.4TP63, IVL, MKI67, CDKN2A, CDKN1B, DAPK1
3keratin filamentGO:04509510.2KRT14, KRT10, KRT8

Biological processes related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell cycle arrestGO:00705010.5TP73, RASSF1, CDKN1B, CDKN2A
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5TP73, TP63
3keratinocyte differentiationGO:03021610.4IVL, KRT10, TP63
4mitotic G1 DNA damage checkpointGO:03157110.2TP73, TP63

Molecular functions related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.5TP73, TP63, CEACAM5, RASSF1, SKP2, DAPK1
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.5CDKN1B, CDKN2A
3p53 bindingGO:00203910.4CDKN2A, TP63, TP73
4protein bindingGO:00551510.2MLH1, MKI67, CDKN2A, CD40, CDKN1B, DAPK1

Products for genes affiliated with Cervical Squamous Cell Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cervical Squamous Cell Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet