MCID: CRV038
MIFTS: 46

Cervical Squamous Cell Carcinoma malady

Summaries for Cervical Squamous Cell Carcinoma

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33MalaCards
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MalaCards: Cervical Squamous Cell Carcinoma, also known as squamous cell carcinoma of the cervix uteri, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Cervical Squamous Cell Carcinoma is SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3), and among its related pathways are Pathways in cancer and MicroRNAs in cancer. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Cervical Squamous Cell Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

cervical squamous cell carcinoma 8 10 45 61
squamous cell carcinoma of the cervix uteri 8
squamous cell carcinoma of cervix 8


External Ids:

Disease Ontology8 DOID:3744
SNOMED-CT57 254886006
NCIt40 C4028

Related Diseases for Cervical Squamous Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cervical Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma32.0TP73, SERPINB3, DAPK1, MKI67
2adenocarcinoma30.8TP73, TP63, CEACAM5, SERPINB3, KRT8, KRT10
3cervical intraepithelial neoplasia30.8TP73, KRT8, KRT10, CDKN2A, MKI67, IVL
4neuroendocrine carcinoma30.5TP63, CEACAM5, KRT8
5squamous cell papilloma10.8
6anal squamous cell carcinoma10.7
7trachoma10.5
8small cell carcinoma10.4
9ovarian squamous cell carcinoma10.4
10microinvasive cervical squamous cell carcinoma10.4
11oral squamous cell carcinoma10.4
12cardiac tamponade10.4
13endometrial squamous cell carcinoma10.4
14fibrous histiocytoma10.3
15keratinizing squamous cell carcinoma10.3
16cervical keratinizing squamous cell carcinoma10.3
17endocervical carcinoma10.2
18anal carcinoma in situ10.2
19cervix small cell carcinoma10.2
20uterine carcinosarcoma10.2
21adrenal carcinoma10.2
22breast adenocarcinoma10.2
23skin squamous cell carcinoma10.2
24vulva squamous cell carcinoma10.2
25ectopic pregnancy10.2
26rare squamous cell carcinoma of the cervix uteri10.2
27hepatocellular carcinoma10.0TP73, CEACAM5, SERPINB3, KRT8, KRT14, RASSF1
28squamous cell carcinoma of the head and neck10.0TP73, TP63, KRT14, RASSF1, MMP14, CXCL14
29retinoblastoma10.0TP73, KRT10, KRT14, RASSF1, SKP2, CDKN1B
30breast cancer10.0TP73, TP63, CEACAM5, KRT8, KRT14, RASSF1
31lung adenocarcinoma10.0TP73, TP63, CEACAM5, KRT8, RASSF1, SKP2
32oral cancer10.0TP73, SERPINB3, KRT14, SKP2, CDKN1B, CDKN2A
33kidney cancer10.0TP73, KRT8, KRT14, RASSF1, DAPK1, CDKN1B
34ovarian cancer10.0TP73, CEACAM5, RASSF1, SKP2, MMP14, CDKN1B
35papilloma10.0TP73, TP63, KRT10, KRT14, RASSF1, CDKN1B
36colorectal cancer10.0TP73, CEACAM5, KRT8, KRT14, RASSF1, DAPK1
37melanoma10.0TP73, TP63, KRT8, KRT14, RASSF1, SKP2
38hepatitis b10.0SERPINB3, KRT8, MMP14, TYMP
39stomach cancer10.0TP73, CEACAM5, RASSF1, SKP2, MMP14, DAPK1
40lung cancer10.0TP73, TP63, CEACAM5, KRT14, MMP14, CD40
41transitional cell carcinoma10.0TP63, KRT8, KRT14, MMP14, DAPK1, TYMP
42keratosis10.0KRT10, IVL
43adenoma10.0TP73, TP63, CEACAM5, KRT8, KRT14, RASSF1
44meningioma10.0TP73, MKI67
45cholangiocarcinoma10.0CEACAM5, KRT8, RASSF1, DAPK1, CDKN1B
46leukoplakia10.0KRT8, MKI67, IVL
47breast fibroadenoma10.0TP63, KRT8, KRT14, RASSF1, MKI67, TIMP2
48leukemia10.0TP73, KRT10, KRT14, SKP2, DAPK1, CDKN1B
49bladder carcinoma10.0KRT8, KRT10, RASSF1, CDKN2A, TYMP, MKI67
50ductal carcinoma in situ10.0KRT14

Graphical network of the top 20 diseases related to Cervical Squamous Cell Carcinoma:



Diseases related to cervical squamous cell carcinoma

Clinical Features for Cervical Squamous Cell Carcinoma

Drugs & Therapeutics for Cervical Squamous Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Cervical Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Cervical Squamous Cell Carcinoma

Search NIH Clinical Center for Cervical Squamous Cell Carcinoma

Search CenterWatch for Cervical Squamous Cell Carcinoma

Genetic Tests for Cervical Squamous Cell Carcinoma

Anatomical Context for Cervical Squamous Cell Carcinoma

Animal Models for Cervical Squamous Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Cervical Squamous Cell Carcinoma

Sources:
51PubMed
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Articles related to Cervical Squamous Cell Carcinoma:

(show top 50)    (show all 349)
idTitleAuthorsYear
1
Primary Squamous Cell Carcinoma of the Upper Genital Tract: Utility of p16(INK4a) Expression and HPV DNA Status in its Differential Diagnosis from Extended Cervical Squamous Cell Carcinoma. (24421848)
2013
2
High TMPRSS4 expression is a predictor of poor prognosis in cervical squamous cell carcinoma. (24012692)
2013
3
Posttreatment cut-off levels of squamous cell carcinoma antigen as a prognostic factor in patients with locally advanced cervical cancer treated with radiotherapy. (24167666)
2013
4
Association between two genetic variants of CD226 gene and Cervical Squamous Cell Carcinoma: a case-control study. (23262348)
2013
5
Cervical squamous cell carcinoma metastatic to placenta. (23896714)
2013
6
A preliminary study of genes related to concomitant chemoradiotherapy resistance in advanced uterine cervical squamous cell carcinoma. (24229683)
2013
7
Oral squamous cell carcinoma presenting as a cervical lymphadenopathy. (24353817)
2013
8
Clinical implication of elevated human cervical cancer oncogene-1 expression in esophageal squamous cell carcinoma. (22511601)
2012
9
Screening test results associated with cancer diagnoses in 287 women with cervical squamous cell carcinoma. (22900617)
2012
10
Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma. (22484437)
2012
11
High expression of TGF-I^1 in the vaginal incisional margin predicts poor prognosis in patients with stage Ib-IIa cervical squamous cell carcinoma. (21773949)
2012
12
Laparoscopic adrenalectomy for isolated adrenal metastasis from cervical squamous cell carcinoma and endometrial adenocarcinoma. (21664660)
2011
13
Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness. (21952923)
2011
14
Small atypical cervical nodes detected on sonography in patients with squamous cell carcinoma of the head and neck: probability of metastasis. (20375372)
2010
15
Umbilical surgical scar and vulval metastasis secondary to advanced cervical squamous cell carcinoma: a report of two cases. (19789888)
2010
16
Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization. (20099975)
2010
17
CT, MR, US,18F-FDG PET/CT, and their combined use for the assessment of cervical lymph node metastases in squamous cell carcinoma of the head and neck. (18843493)
2009
18
Symmetric division and expression of its regulatory gene Numb in human cervical squamous carcinoma cells. (19468255)
2009
19
Cytology of metastatic cervical squamous cell carcinoma in pleural fluid: report of a case confirmed by human papillomavirus typing. (19217045)
2009
20
Phase I study of combination chemotherapy with irinotecan hydrochloride and nedaplatin for cervical squamous cell carcinoma: Japanese gynecologic oncology group study. (19288001)
2009
21
Molecular cytogenetic analysis of cervical squamous cell carcinoma cells demonstrates discordant levels of numerical and structural chromosomal instability and identifies 'selected' chromosome rearrangements. (20224276)
2009
22
Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy. (19030960)
2008
23
Expressions of EphA2 and EphrinA-1 in early squamous cell cervical carcinomas and their relation to prognosis. (18566674)
2008
24
Expression of Skp2 in cervical squamous cell carcinoma and precancerous lesions and its correlation with HPV16/18 infection]. (19094580)
2008
25
Loss of epithelium cadherin expression is associated with reduced overall survival and disease-free survival in early-stage squamous cell cervical carcinoma. (17343572)
2007
26
Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. (17503414)
2007
27
High-risk human papillomavirus E7 oncoprotein detection in cervical squamous cell carcinoma. (18056184)
2007
28
Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma. (17391312)
2007
29
Angiogenesis in cervical intraepithelial neoplasia and early-staged uterine cervical squamous cell carcinoma: clinical significance. (16681728)
2006
30
Cyclin D1 gene numerical aberration is a predictive marker for occult cervical lymph node metastasis in TNM Stage I and II squamous cell carcinoma of the oral cavity. (16265665)
2005
31
S100A2 expression as a predictive marker for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral cavity. (16273244)
2005
32
Preliminary estimation of treatment effect on uterine cervical squamous cell carcinoma in terms of tumor regression rate: comparison between chemoradiotherapy and radiotherapy alone. (15786748)
2005
33
Expression of VEGF-C and VEGFR-3 in human laryngeal squamous cell carcinomas and cervical metastatic lymph node tissues]. (15715411)
2004
34
Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas. (14662411)
2004
35
Expression of hypoxic-inducible factor 1alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma. (15380586)
2004
36
Transient increase in squamous cell carcinoma antigen expression in cultured cervical carcinoma CaSki cells in response to exposure to cis-diamminedichloroplatinum. (15001834)
2003
37
Is the human papillomavirus a mutual aetiological agent in oral and cervical squamous cell carcinoma? (12926099)
2003
38
Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma. (12883684)
2003
39
Neoadjuvant treatment with docetaxel and the effects of irradiation for human ovarian adenocarcinoma and cervical squamous cell carcinoma in vitro. (11873939)
2002
40
P53 expression as a predictor of recurrence in cervical squamous cell carcinoma. (12060452)
2002
41
Suppression of growth by all-trans retinoic acid requires prolonged induction of interferon regulatory factor 1 in cervical squamous carcinoma (SiHa) cells. (12204966)
2002
42
Immunohistochemical and DNA sequencing analysis on human mismatch repair gene MLH1 in cervical squamous cell carcinoma with LOH of this gene. (10769651)
2000
43
Predictive value of cathepsin-D for cervical lymph node metastasis in head and neck squamous cell carcinoma. (10562684)
1999
44
The evaluation of cytokeratin 18 expression in cervical squamous cell carcinoma. (10353000)
1999
45
Possible involvement of tumour-derived interleukin-6 in dermatomyositis associated with cervical squamous cell carcinoma. (9115948)
1997
46
Cyfra 21-1 in monitoring cervical cancer: a comparison with tissue polypeptide antigen and squamous cell carcinoma antigen. (9245246)
1997
47
Angiogenesis in uterine cervical squamous cell carcinoma. (8601522)
1995
48
Age is prognostic variable in cervical squamous cell carcinoma. (8344321)
1993
49
Recurrent cervical squamous cell carcinoma presenting with cardiac tamponade. Recurrent cervical carcinoma-tamponade. (1627330)
1992
50
Prognostic flow cytometric information in cervical squamous cell carcinoma: a multivariate analysis of 307 patients. (1959785)
1991

Genetic Variations for Cervical Squamous Cell Carcinoma

Expression for genes affiliated with Cervical Squamous Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervical Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Squamous Cell Carcinoma.

Pathways for genes affiliated with Cervical Squamous Cell Carcinoma

Sources:
30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore, 52QIAGEN, 54Reactome
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Compounds for genes affiliated with Cervical Squamous Cell Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1progesterone45 60 29 11 2415.0SKP2, KRT14, KRT10, KRT8, CEACAM5, TP63
2paraffin4511.0MLH1, IVL, MKI67, TYMP, CDKN2A, CD40
3retinoic acid45 2412.0SKP2, DAPK1, KRT10, KRT8, TP63, TP73
4serine4511.0DAPK1, TIMP2, CDKN2A, CD40, MMP14, TYMP
5p0034511.0TP73, TP63, CEACAM5, RASSF1, CDKN1B, CD40
6threonine4511.0DAPK1, MKI67, TP73, KRT8, KRT10, KRT14
7vegf4511.0CDKN2A, MMP14, CDKN1B, CD40, TYMP, MKI67
8bromodeoxyuridine4511.0KRT14, TP63, KRT8, KRT10, MKI67, IVL
9cisplatin45 50 60 1114.0KRT8, CEACAM5, TP63, TP73, KRT14, CDKN2A
10tyrosine4510.9TYMP, MKI67, TP63, CEACAM5, KRT8, KRT10
11p000014510.9MLH1, MKI67, TYMP, CDKN2A, CDKN1B, MMP14
12hematoxylin4510.9TP63, CEACAM5, KRT8, KRT10, KRT14, CDKN2A
13doxorubicin45 50 1112.9CDKN1B, KRT8, MLH1, CEACAM5, CD40, TYMP
14p0024510.9TP73, CEACAM5, TIMP2, MLH1, MKI67, TYMP
15thymidine45 2411.9MKI67, TYMP, CD40, CDKN1B, TP63, MMP14
165fluorouracil4510.9CDKN2A, TIMP2, MLH1, IVL, MKI67, TYMP
17estrogen4510.9IVL
18oligonucleotide4510.9TIMP2, TP73, KRT8, RASSF1, SKP2, MMP14
19crcs4510.9RASSF1, CDKN2A, TYMP, MLH1, DAPK1, CEACAM5
20glucose4510.9TYMP, CDKN2A, IVL, KRT8, TIMP2, CDKN1B
21actinomycin d4510.9KRT8, TYMP, TP73, MMP14, CDKN1B, CD40
22steroid4510.9MKI67, CDKN2A, CD40, KRT10, KRT8
23paclitaxel45 50 1112.9TIMP2, TYMP, KRT8, CDKN2A, CDKN1B, MLH1
24cysteine4510.9SERPINB3, TIMP2, IVL, TYMP, CDKN2A, MMP14
25butyrate4510.9CD40
26o6-methylguanine4510.9MLH1, CDKN2A, DAPK1, RASSF1, TP73
27calcium45 50 11 2413.9TIMP2, DAPK1, MMP14, KRT14, KRT10, KRT8
28methotrexate45 50 1112.9CD40, TYMP, MKI67, IVL, TIMP2, CDKN2A
29cytosine45 2411.9MLH1, KRT14, CEACAM5, TYMP, CDKN2A, RASSF1
30sodium bisulfite4510.8RASSF1, DAPK1, CDKN2A, MLH1
315-aza-2deoxycytidine4510.8DAPK1, RASSF1, TP73, TIMP2, MLH1, CDKN2A
32cycloheximide4510.8KRT8, TYMP
33lipid4510.8IVL, KRT14, CEACAM5, TP73, MMP14, CD40
345-methylcytosine45 2411.8MLH1, RASSF1, DAPK1, CDKN2A
35oxygen45 2411.8CDKN2A, IVL, CD40, TYMP, MKI67, MLH1
36cholesterol45 29 11 2413.8TIMP2, IVL, CDKN2A, CD40, CDKN1B, MMP14
37irinotecan45 50 1112.8MKI67, MLH1, TYMP, CDKN2A, CEACAM5
38chloramphenicol45 2 1112.8KRT14, MMP14, CD40, IVL, CDKN2A, TP73
39agar4510.8MMP14, KRT8, CEACAM5, CDKN1B, CDKN2A, RASSF1
40fatty acid4510.7CDKN2A, CDKN1B, KRT10, TP73, IVL, MLH1
41mitomycin c4510.7CEACAM5, MKI67, TYMP, CD40, TP63
42azathioprine45 50 2 1113.7MLH1, TP73, RASSF1, TIMP2, CDKN2A
43arginine4510.7MLH1, MKI67, CDKN2A, CDKN1B, KRT14, KRT10
4412-o-tetradecanoylphorbol 13-acetate4510.7CDKN1B, TIMP2, IVL, TYMP, CD40, MMP14
45tamoxifen45 50 29 1113.6KRT14, TIMP2, MKI67, TYMP, KRT8, CDKN1B
46ly2940024510.6CD40, SKP2, MMP14, CDKN1B, TYMP, TIMP2
47glyceraldehyde 3-phosphate4510.5CEACAM5, KRT10, MMP14, TYMP, TIMP2
48folate4510.5RASSF1, TYMP, MLH1, MKI67, CDKN2A
49genistein45 29 60 2 11 2415.4CDKN2A, CDKN1B, CD40, MMP14, TIMP2, KRT8
50proline4510.2IVL, MKI67, KRT14, TP73, KRT10, MLH1

GO Terms for genes affiliated with Cervical Squamous Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.5KRT8, KRT10, KRT14
2cytoplasmGO:00573710.4TP63, IVL, MKI67, CDKN2A, CDKN1B, DAPK1
3keratin filamentGO:04509510.2KRT14, KRT10, KRT8

Biological processes related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell cycle arrestGO:00705010.5CDKN2A, TP73, RASSF1, CDKN1B
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5TP63, TP73
3keratinocyte differentiationGO:03021610.4IVL, TP63, KRT10
4mitotic G1 DNA damage checkpointGO:03157110.2TP73, TP63

Molecular functions related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.5DAPK1, SKP2, RASSF1, CEACAM5, TP63, TP73
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.5CDKN2A, CDKN1B
3p53 bindingGO:00203910.4TP73, TP63, CDKN2A
4protein bindingGO:00551510.2KRT8, TP73, MLH1, MKI67, CDKN2A, CD40

Products for genes affiliated with Cervical Squamous Cell Carcinoma

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Sources for Cervical Squamous Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet