MCID: CRV038
MIFTS: 50

Cervical Squamous Cell Carcinoma malady

Cancer diseases category
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Summaries for Cervical Squamous Cell Carcinoma

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Disease Ontology:8 A cervix carcinoma that has material basis in squamous cells of the cervix.

MalaCards based summary: Cervical Squamous Cell Carcinoma, also known as squamous cell carcinoma of the cervix uteri, is related to cervical intraepithelial neoplasia and adenosquamous carcinoma. An important gene associated with Cervical Squamous Cell Carcinoma is SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Matrix Metalloproteinases. The compounds calcipotriol and ethylenediaminetetraacetic acid have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and ovary, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Aliases & Classifications for Cervical Squamous Cell Carcinoma

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Cervical Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Cervical Squamous Cell Carcinoma 30 8 10 44 62
Squamous Cell Carcinoma of the Cervix Uteri 8 62
 
Squamous Cell Carcinoma of Cervix 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3744
SNOMED-CT57 254886006
NCIt39 C4028

Related Diseases for Cervical Squamous Cell Carcinoma

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Diseases related to Cervical Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia30.8TP73, KRT8, KRT10
2adenosquamous carcinoma30.8TYMP, KRT8
3cervical adenocarcinoma30.6KRT8, RASSF1
4papilloma30.0RASSF1, KRT10, TP73, KRT14
5adenocarcinoma28.9KRT8, KRT14, TP73, KRT10, SERPINB3, TYMP
6cervicitis11.4
7microinvasive cervical squamous cell carcinoma10.5
8cardiac tamponade10.4
9neuroendocrine carcinoma10.4
10small cell neuroendocrine carcinoma10.4
11endometrial adenocarcinoma10.4
12keratoacanthoma10.4
13serous cystadenocarcinoma10.3TYMP, MMP14
14bowen syndrome10.3KRT14, KRT10
15keratinizing squamous cell carcinoma10.3
16fibrous histiocytoma10.3
17anal squamous cell carcinoma10.3
18histiocytoma10.3
19sarcoma10.3
20nonepidermolytic palmoplantar keratoderma10.3KRT14, KRT10
21epidermolysis bullosa simplex10.3KRT14, KRT10
22pancreatic ductal carcinoma10.3TYMP, KRT8
23laryngeal benign neoplasm10.2SERPINB3, MMP14
24cholesteatoma10.2KRT14, KRT10
25craniopharyngioma10.2KRT8, KRT14
26endocervicitis10.2
27breast adenocarcinoma10.2
28cervical carcinosarcoma10.2
29dermatomyositis10.2
30vaginitis10.2
31neuroendocrine carcinoma of the cervix10.2
32rare squamous cell carcinoma of the cervix uteri10.2
33chordoma10.2KRT14, KRT8
34angiosarcoma10.2KRT8, KRT14
35ameloblastoma10.2KRT8, KRT14
36skin disease10.2KRT10, KRT14, CD40
37bladder carcinoma in situ10.1SERPINB3, RASSF1
38abdominal aortic aneurysm10.1MMP14, TIMP2
39plasma cell leukemia10.1TP73, CD40
40breast ductal carcinoma10.1KRT8, TIMP2
41keloids10.1TIMP2, KRT14
42psoriasis10.1KRT14, CD40, KRT10, SERPINB3
43endometriosis10.1TIMP2, MMP14, TYMP
44gallbladder cancer10.1KRT8, TIMP2, TYMP
45kidney rhabdoid cancer10.1TYMP, RASSF1
46oxyphilic adenoma10.1KRT14, RASSF1, KRT8
47synovial sarcoma10.1KRT8, RASSF1, KRT14
48hepatitis b10.0SERPINB3, TYMP, MMP14, KRT8
49familial adenomatous polyposis10.0MMP14, DAPK1, RASSF1
50cholangiocarcinoma10.0RASSF1, DAPK1, KRT8

Graphical network of the top 20 diseases related to Cervical Squamous Cell Carcinoma:



Diseases related to cervical squamous cell carcinoma

Symptoms for Cervical Squamous Cell Carcinoma

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Drugs & Therapeutics for Cervical Squamous Cell Carcinoma

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Drug clinical trials:

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Search NIH Clinical Center for Cervical Squamous Cell Carcinoma

Genetic Tests for Cervical Squamous Cell Carcinoma

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Anatomical Context for Cervical Squamous Cell Carcinoma

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MalaCards organs/tissues related to Cervical Squamous Cell Carcinoma:

32
Cervix, Lymph node, Ovary, Placenta, Testes, Lung, Breast, Skin, Testis

Animal Models for Cervical Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Cervical Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.7TP73, MMP14, KRT10, KRT14
2MP:00053828.6KRT14, KRT10, MMP14, TP73
3MP:00020068.1TP73, RASSF1, KRT10, KRT14
4MP:00053977.5TP73, TIMP2, MMP14, KRT8, KRT14, CD40
5MP:00053847.5DAPK1, TYMP, TP73, MMP14, RASSF1, KRT14
6MP:00036317.4DAPK1, TYMP, TP73, TIMP2, MMP14, CD40
7MP:00053766.7DAPK1, TYMP, TP73, TIMP2, MMP14, RASSF1
8MP:00053876.5CD40, TYMP, TP73, TIMP2, MMP14, RASSF1

Publications for Cervical Squamous Cell Carcinoma

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Articles related to Cervical Squamous Cell Carcinoma:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
Cervical squamous cell carcinoma with isolated tibial metastasis: A case report and review of the literature. (25364422)
2014
2
Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma. (24659184)
2014
3
IMP3 expression is associated with poor survival in cervical squamous cell carcinoma. (25176620)
2014
4
Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery. (24405714)
2014
5
Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells. (24689999)
2014
6
Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics. (24385692)
2013
7
Case of metastatic uterine cervical squamous cell carcinoma in the right atrium. (23564576)
2013
8
Primary Squamous Cell Carcinoma of the Upper Genital Tract: Utility of p16(INK4a) Expression and HPV DNA Status in its Differential Diagnosis from Extended Cervical Squamous Cell Carcinoma. (24421848)
2013
9
Genetic variants in interleukin-18 gene and risk for cervical squamous cell carcinoma. (23603311)
2013
10
ERCC1 mRNA levels can predict the response to cisplatin-based concurrent chemoradiotherapy of locally advanced cervical squamous cell carcinoma. (23259415)
2012
11
Screening test results associated with cancer diagnoses in 287 women with cervical squamous cell carcinoma. (22900617)
2012
12
Recurrence during pregnancy of a conservatively treated early-stage cervical squamous cell carcinoma. (20655526)
2011
13
Laparoscopic adrenalectomy for isolated adrenal metastasis from cervical squamous cell carcinoma and endometrial adenocarcinoma. (21664660)
2011
14
Two novel unbalanced whole arm translocations are frequently detected in cervical squamous cell carcinoma. (22285016)
2011
15
Reduced expression of I9I9p63I+ inA cervical squamous cell carcinoma. (21631996)
2011
16
Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma. (21319225)
2011
17
Influence of lymph vascular space invasion on prognosis of patients with early-stage cervical squamous cell carcinoma. (20346220)
2010
18
Expression of PSCA, PIWIL1 and TBX2 and its correlation with HPV16 infection in formalin-fixed, paraffin-embedded cervical squamous cell carcinoma specimens. (20229117)
2010
19
Significant effects of lymph and blood vascular invasion on the prognosis of early-stage cervical squamous cell carcinoma. (20846259)
2010
20
Plasma proteome analysis of cervical intraepithelial neoplasia and cervical squamous cell carcinoma. (20093745)
2009
21
Cyclooxygenase-2 expression in cervical squamous cell carcinoma: the significance of expression in neoplastic cells within the lymphovascular space. (20192574)
2009
22
Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma. (19638983)
2009
23
Microarray profile of micro-ribonucleic acid in tumor tissue from cervical squamous cell carcinoma without human papillomavirus. (20149030)
2009
24
Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy. (19030960)
2008
25
Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. (17503414)
2007
26
Early determination of uterine cervical squamous cell carcinoma radioresponse identifies high- and low-response tumors. (16343805)
2006
27
Expression and clinical significance of autophagy gene Beclin 1 in cervical squamous cell carcinoma]. (17236580)
2006
28
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. (16425263)
2006
29
HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and meta-analysis. (16720214)
2006
30
Tumor lymphangiogenesis in cervical squamous cell carcinoma and its clinical significance]. (16179117)
2005
31
Cell proliferation of bulky cervical squamous cell carcinoma is strongly associated with a paracrine tissue-specific growth factor(s). (16211274)
2005
32
P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma. (14599865)
2003
33
Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma. (12798701)
2003
34
Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia. (12100520)
2002
35
Chlamydia trachomatis and cervical squamous cell carcinoma. (11277820)
2001
36
Karyometric features differentiate early invasive cervical squamous cell carcinoma from preinvasive carcinoma. (11915180)
2001
37
Increased carcinoembryonic antigen expression in cervical intraepithelial neoplasia grade 3 and in cervical squamous cell carcinoma. (11112209)
2000
38
Relative changes of MIB1 and PC10 labeling indexes in cell kinetics during radiotherapy for cervical squamous cell carcinoma. (9490095)
1997
39
Possible involvement of tumour-derived interleukin-6 in dermatomyositis associated with cervical squamous cell carcinoma. (9115948)
1997
40
Expression of retinoic acid receptor-beta 2 mRNA in normal cervical epithelium and cervical squamous cell carcinoma. (21528293)
1997
41
Cervical squamous cell carcinoma and its precursor lesions: cytodiagnostic criteria and pitfalls. (9390926)
1996
42
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study. (8697388)
1996
43
Angiogenesis in uterine cervical squamous cell carcinoma. (8601522)
1995
44
Age is prognostic variable in cervical squamous cell carcinoma. (8344321)
1993
45
Intrinsic resistance of cervical squamous cell carcinoma cell lines to methotrexate (MTX) as a result of decreased accumulation of intracellular MTX polyglutamates. (7694891)
1993
46
Expression of ras oncogene product and EGF receptor in cervical squamous cell carcinomas and its relationship to lymph node involvement. (1707025)
1991
47
Keratoacanthomas associated with cervical squamous cell carcinoma. (4004294)
1985
48
Tumor-antigen TA-4 in the detection of recurrence in cervical squamous cell carcinoma. (6478396)
1984
49
Tumor antigen of human cervical squamous cell carcinoma: correlation of circulating levels with disease progress. (421183)
1979
50
Biological properties and radiation responses of the hamster uterine cervical squamous cell carcinoma. (441259)
1979

Variations for Cervical Squamous Cell Carcinoma

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Expression for genes affiliated with Cervical Squamous Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Cervical Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Squamous Cell Carcinoma.

Pathways for genes affiliated with Cervical Squamous Cell Carcinoma

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Pathways related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6KRT14, KRT8
2
Show member pathways
9.5MMP14, TIMP2
3
Show member pathways
Signaling Pathways in Glioblastoma37
9.1RASSF1, TYMP, DAPK1

Compounds for genes affiliated with Cervical Squamous Cell Carcinoma

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Compounds related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1calcipotriol44 61 28 1112.9KRT14, KRT10
2ethylenediaminetetraacetic acid449.7MMP14, TIMP2
3cytochalasin449.7TIMP2, MMP14
4hematoxylin449.7KRT8, KRT10, KRT14
5sodium bisulfite449.6DAPK1, RASSF1
6p00001449.6MMP14, TIMP2, TYMP
75-methylcytosine44 2410.5DAPK1, RASSF1
8cytosine44 2410.5RASSF1, KRT14, TYMP
9crcs449.5TYMP, RASSF1, DAPK1
10herbimycin a44 6110.4CD40, TIMP2, MMP14
11bromodeoxyuridine449.4MMP14, KRT10, KRT14, KRT8
12retinoid449.3KRT8, KRT14, KRT10
13glyceraldehyde 3-phosphate449.2MMP14, TIMP2, TYMP, KRT10
14methotrexate50 44 1111.2CD40, TIMP2, TYMP
1512-o-tetradecanoylphorbol 13-acetate449.2MMP14, CD40, TIMP2, TYMP
16ly294002449.1TYMP, CD40, MMP14, TIMP2
17thymidine44 2410.1CD40, MMP14, TIMP2, TYMP
18matrigel449.1KRT8, TYMP, MMP14, TIMP2
19paclitaxel44 50 1111.1TIMP2, CD40, KRT8, TYMP
20o6-methylguanine449.0DAPK1, RASSF1, TP73
21tamoxifen44 50 28 1112.0KRT8, TIMP2, TYMP, KRT14
22creatinine449.0TYMP, TIMP2, KRT8, CD40
23butyrate449.0TIMP2, KRT8, KRT14, CD40
24genistein44 28 61 2 24 1114.0CD40, KRT8, MMP14, TIMP2
25chloramphenicol44 2 50 1111.9TP73, MMP14, KRT14, CD40
26cholesterol44 28 24 1111.9CD40, TIMP2, MMP14, KRT14
27doxorubicin44 50 1110.9TYMP, TP73, CD40, KRT8
28agar448.8RASSF1, MMP14, KRT8
29steroid448.8CD40, KRT10, KRT8, TIMP2
30azathioprine44 2 50 1111.8TP73, RASSF1, TIMP2
31p002448.8TP73, TYMP, TIMP2, MMP14
32cycloheximide448.7TIMP2, MMP14, CD40, TYMP, KRT8
335fluorouracil448.6TP73, TIMP2, TYMP
345-aza-2deoxycytidine448.4TIMP2, TP73, DAPK1, RASSF1
35cisplatin44 50 61 1111.4RASSF1, KRT8, KRT14, TP73, TYMP
36glucose448.4CD40, TYMP, TIMP2, KRT8, KRT14, MMP14
37p003448.3CD40, TIMP2, RASSF1, TP73, TYMP
38cysteine448.1KRT8, KRT14, SERPINB3, TYMP, MMP14, TIMP2
39actinomycin d448.0MMP14, KRT8, TYMP, CD40, TIMP2, TP73
40vegf448.0KRT8, MMP14, TYMP, TIMP2, CD40, TP73
41lipid447.8MMP14, TP73, TIMP2, KRT8, KRT14, CD40
42calcium44 50 24 1110.8MMP14, CD40, KRT8, KRT14, KRT10, TIMP2
43oligonucleotide447.8KRT8, TP73, RASSF1, MMP14, TIMP2, CD40
44paraffin447.3KRT10, KRT8, MMP14, CD40, TYMP, TP73
45progesterone44 28 61 24 1111.3TP73, TIMP2, MMP14, KRT10, KRT14, CD40
46tyrosine447.3TYMP, TP73, TIMP2, MMP14, KRT14, KRT10
47threonine447.2CD40, KRT14, KRT10, KRT8, MMP14, TP73
48retinoic acid44 247.9TIMP2, KRT8, KRT10, RASSF1, KRT14, CD40
49serine446.8KRT8, KRT10, KRT14, CD40, RASSF1, MMP14
50estrogen446.6KRT8, MMP14, TP73, KRT10, DAPK1, RASSF1

GO Terms for genes affiliated with Cervical Squamous Cell Carcinoma

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Cellular components related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.3KRT10, KRT14, KRT8
2intermediate filamentGO:0058829.2KRT10, KRT8, KRT14
3extracellular spaceGO:0056158.9TIMP2, SERPINB3, KRT10, CD40
4extracellular vesicular exosomeGO:0700628.4CD40, KRT8, KRT10, KRT14, SERPINB3
5cytoplasmGO:0057377.3DAPK1, SERPINB3, MMP14, RASSF1, KRT8, KRT10

Biological processes related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of proteolysisGO:0458619.6SERPINB3, TIMP2

Molecular functions related to Cervical Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4CD40, KRT14, KRT8, RASSF1, MMP14, TIMP2

Products for genes affiliated with Cervical Squamous Cell Carcinoma

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Sources for Cervical Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet