MCID: CRV039
MIFTS: 57

Cervicitis malady

Reproductive diseases category

Summaries for Cervicitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Cervicitis is inflammation of the uterine cervix. Cervicitis in women has many features in common with... more...

MalaCards: Cervicitis, also known as cervicitis and endocervicitis, is related to tuberculosis and multiple sclerosis. An important gene associated with Cervicitis is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are Validated targets of C-MYC transcriptional activation and Signaling by Interleukins. The compounds cdcl2 and amp-pnp have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spinal cord and cervix, and related mouse phenotype mortality/aging.

Aliases & Classifications for Cervicitis

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

cervicitis 9 46
cervicitis and endocervicitis 9
uterine cervicitis 63


Related Diseases for Cervicitis

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18GeneCards, 19GeneDecks
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Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Cervicitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1178)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.3HSPD1, HSPA4, IL2, IL2RA
2multiple sclerosis30.3IL2RA, IL2, HSPD1
3rheumatoid arthritis30.2HSPD1, IL2, IL2RA
4leukemia30.1HSPA4, IL2, IL2RA
5sarcoidosis30.0HSPA4, IL2, IL2RA
6leprosy30.0IL2
7diabetes mellitus29.9HSPA4, HSPD1
8melanoma29.9HSPD1, HSPA4, IL2
9vulvovaginitis29.8HSPA4, HSPD1
10severe combined immunodeficiency29.7IL2RA, IL2
11hodgkin's lymphoma29.7IL2RA, IL2, HSPA4
12cataract29.5HSPD1, HSPA4
13mycosis fungoides29.5IL2, IL2RA
14hepatitis b29.5HSPA4, IL2
15graft versus host disease29.5IL2, IL2RA
16diphtheria29.5IL2RA, IL2
17eosinophilia29.5IL2, IL2RA
18b-cell chronic lymphocytic leukemia29.5IL2, IL2RA
19behcet's disease29.5IL2RA, HSPD1
20chronic lymphocytic leukemia29.5IL2RA, IL2
21t-cell leukemia29.5IL2RA, IL2
22tetanus29.4HSPD1, IL2, IL2RA
23systemic lupus erythematosus29.4HSPD1, IL2, IL2RA
24cervical cancer11.3
25cervical intraepithelial neoplasia11.1
26dystonia11.0
27cervical dystonia11.0
28spondylosis11.0
29adenocarcinoma10.9
30cervical adenocarcinoma10.9
31radiculopathy10.8
32cervical squamous cell carcinoma10.8
33cervical incompetence10.8
34vaginitis10.7
35cervical adenitis10.7
36lymphadenitis10.7
37thyroiditis10.7
38papilloma10.6
39epidural abscess10.6
40dysphagia10.6
41quadriplegia10.6
42spinal cord injury10.6
43whiplash10.6
44chronic cervicitis10.5
45adenocarcinoma in situ10.5
46fasciitis10.5
47klippel-feil syndrome10.5
48degenerative disc disease10.5
49endotheliitis10.5
50midline cervical cleft10.5

Graphical network of the top 20 diseases related to Cervicitis:



Diseases related to cervicitis

Symptoms for Cervicitis

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Drugs & Therapeutics for Cervicitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cervicitis

Drug clinical trials:

Search ClinicalTrials for Cervicitis

Search NIH Clinical Center for Cervicitis

Search CenterWatch for Cervicitis

Genetic Tests for Cervicitis

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Anatomical Context for Cervicitis

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34MalaCards
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MalaCards organs/tissues related to Cervicitis:

34
Lymph node, Spinal cord, Cervix, Testes, Thyroid, Bone, Breast, Endothelial, Brain, T cells, Uterus, Tongue, Lung, Thymus, Colon, Tonsil, Placenta, Ovary, Prostate, Salivary gland, Monocytes, Skin, Liver, Globus pallidus, Cortex, B cells, Subthalamic nucleus, Pituitary, Pineal, Myeloid, Bone marrow, Smooth muscle, Nk cells, Trachea, Heart, Medulla oblongata, Small intestine, Kidney, Occipital lobe, Testis, Appendix, Cerebellum, Pons

Animal Models for Cervicitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Cervicitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0IL2RA, IL2, HSPA4, HSPD1

Publications for Cervicitis

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53PubMed
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Articles related to Cervicitis:

(show top 50)    (show all 8788)
idTitleAuthorsYear
1
Cytotoxic function of gamma delta (gamma/delta) T cells against pamidronate-treated cervical cancer cells. (24228383)
2013
2
Promoters of and barriers to cervical cancer screening in a rural setting in Tanzania. (24095307)
2013
3
The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling. (24145114)
2013
4
Women whose cervical intraepithelial neoplasia has been treated or resolved remain at continued high risk for cervical cancer. (23378629)
2013
5
Cervical rib resulting in amaurosis fugax and stroke. (24035686)
2013
6
Cellular retinol binding protein 1 could be a tumor suppressor gene in cervical cancer. (24040446)
2013
7
Multilevel anterior cervical discectomy and fusion with and without rhBMP-2: a comparison of dysphagia rates and outcomes in 150 patients. (23157278)
2013
8
Human papillomavirus detected in a colonic metastasis of cervical adenocarcinoma. (23549714)
2013
9
The optimized acupuncture treatment for neck pain caused by cervical spondylosis: a study protocol of a multicentre randomized controlled trial. (22776567)
2012
10
Neurofibroma of the cervix presenting as cervical stenosis in a patient with neurofibromatosis type 1: a case report. (22317879)
2012
11
Cervical metastasis of germ cell tumors: evaluation, management, complications, and outcomes. (22252920)
2012
12
Temporary endovascular balloon occlusion of the bilateral internal iliac arteries to control hemorrhage during laparoscopic-assisted vaginal hysterectomy for cervical myoma. (21658835)
2011
13
Somatosensory temporal discrimination tested in patients receiving botulinum toxin injection for cervical dystonia. (21506155)
2011
14
Quality of life among Thai women diagnosed with cervical cancer and cervical intraepithelial neoplasia at King Chulalongkorn Memorial Hospital. (21863670)
2011
15
Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis. (21223574)
2011
16
Cytokine serum levels in patients with cervical intraepithelial neoplasia grade II-III treated with intralesional interferon-I+ 2b. (22158487)
2011
17
Case report: Langerhans cell histiocytosis presenting as massive cervical adenopathy and retropharyngeal thickening: importance of chest radiography and coordinated airway and anesthetic management. (20145506)
2010
18
Increased serum progesterone and estradiol correlate to increased COX-2 tissue expression in cervical intraepithelial neoplasia. (20530431)
2010
19
Chinese herbal medicine for chronic neck pain due to cervical degenerative disc disease. (20091597)
2010
20
Postoperative adjuvant chemotherapy for node-positive cervical adenocarcinoma. (19396009)
2009
21
Ectopic thymus presenting as a right-side cervical mass in an infant. (18839165)
2009
22
Successfully conservative treatment of large cervical choriocarcinoma with profuse vaginal bleeding. (19260253)
2009
23
HPV16 E6-induced and E6AP-dependent inhibition of the transcriptional coactivator hADA3 in human cervical carcinoma cells. (19194825)
2009
24
Promoter methylation of DAPK gene in cervical carcinoma]. (18799028)
2008
25
Cervical radiculopathy secondary to Hodgkin's lymphoma. (17445629)
2007
26
Molecular profiling of cervical cancer progression. (17242701)
2007
27
Evaluation of matrix metalloproteinase 2 expression in cervical carcinogenesis using tissue array and integrated optical density for immunoreactivity. (18000234)
2007
28
Cervical interlaminar epidural steroid injection for neck pain and cervical radiculopathy: effect and prognostic factors. (17340166)
2007
29
Radiological grading of cervical destructive spondyloarthropathy in long-term hemodialysis patients. (16891979)
2006
30
Polymorphic amino acids at codons 9 and 37 of HLA-DQB1 alleles may confer susceptibility to cervical cancer among Chinese women. (16425277)
2006
31
A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions. (16189158)
2005
32
Pro-apoptotic efficiencies of three reconstructed human caspase-8 on cervical cancer cell line HeLa]. (15694025)
2005
33
Mental retardation in a boy with anterior cervical hypertrichosis. (15800907)
2005
34
Increased apoptosis in cervical intraepithelial neoplasia associated with HIV infection: implication of oncogenic human papillomavirus, caspases, and Langerhans cells. (15814619)
2005
35
Cervical epidural abscess associated with massively elevated erythrocyte sedimentation rate. (14751486)
2004
36
A recurrent intradural cervical neurenteric cyst operated on using an anterior approach: a case report. (12633954)
2003
37
Cervical lymphadenopathy caused by Kikuchi disease: positron emission tomographic appearance. (12642715)
2003
38
Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomes. (12359427)
2002
39
Diagnosis and treatment of intramedullary hemangioblastoma of cervical spinal cord. (12150732)
2002
40
Codon 72 polymorphism of p53 in Israeli Jewish cervical cancer patients and healthy women. (12445252)
2002
41
Neonatal cervical osteomyelitis with paraspinal abscess and Erb's palsy. A case report and brief review of the literature. (10965268)
2000
42
Adenocarcinoma in situ with a small cell (endometrioid) pattern in cervical smears: a test of the distinction from benign mimics using specific criteria. (10536349)
1999
43
Secretory leukocyte protease inhibitor (SLPI) concentrations in cervical mucus of women with normal menstrual cycle. (10381821)
1999
44
Prolapsed ovarian cyst through cervical stump: a rare complication of a subtotal hysterectomy. (15512157)
1998
45
Opportunistic screening for Chlamydia trachomatis cervicitis: the value of cytobrush specimens for detection by PCR compared with cell culture. (9674896)
1998
46
Aneurysm of the transverse cervical artery occurring in association with a cavernous hemangioma as a complication of Klippel-TrAcnaunay syndrome: report of a case. (8640026)
1995
47
Molecular biological study on the overexpression of c-myc gene in uterine cervical carcinomas]. (1619315)
1992
48
Cervical instability as an unusual manifestation of Hajdu-Cheney syndrome of acroosteolysis. (2347142)
1990
49
Oral lymphogranuloma venereum and cervical lymphadenopathy. Case report. (4204816)
1974
50
Management of cervical incompetence. (5347310)
1969

Variations for Cervicitis

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Expression for genes affiliated with Cervicitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cervicitis

Search GEO for disease gene expression data for Cervicitis.

Pathways for genes affiliated with Cervicitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 54QIAGEN, 62Tocris Bioscience, 5Cell Signaling Technology, 55R&D Systems, 31KEGG
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Pathways related to Cervicitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4HSPD1, HSPA4
2
Show member pathways
9.0IL2RA, IL2
3
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.0IL2RA, IL2
4
Show member pathways
9.0IL2RA, IL2
5
Show member pathways
9.0IL2, IL2RA
6
Show member pathways
9.0IL2RA, IL2
79.0IL2RA, IL2
8
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.0IL2RA, IL2
9
Show member pathways
Type III interferon signaling39
9.0IL2RA, IL2
10
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.0IL2, IL2RA
119.0IL2RA, IL2
129.0IL2RA, IL2
13
Show member pathways
9.0IL2, IL2RA
14
Show member pathways
IL2 signaling events mediated by STAT539
9.0IL2, IL2RA
15
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.0IL2RA, IL2
16
Show member pathways
Immune response IL 3 activation and signaling pathway61
9.0IL2RA, IL2
17
Show member pathways
IL-2 Signaling pathway39
9.0IL2, IL2RA
18
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.0IL2RA, IL2
19
Show member pathways
8.0IL2RA, IL2, HSPA4, HSPD1

Compounds for genes affiliated with Cervicitis

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Cervicitis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1cdcl2469.8HSPD1, HSPA4
2amp-pnp30 4610.8HSPA4, HSPD1
3tuberculin469.7HSPD1, IL2RA
4toxin-1469.5IL2, HSPD1
5nitrate469.5IL2RA, HSPD1
6rrna469.5IL2RA, HSPD1
7mizoribine469.5IL2, IL2RA
8denileukin diftitox46 52 1211.5IL2RA, IL2
9pentostatin46 62 30 1212.5IL2, IL2RA
10c-d4t469.5IL2RA, IL2
11git 27629.4IL2RA, IL2
124-ipp629.4IL2RA, IL2
13daclizumab46 1210.4IL2, IL2RA
14basiliximab46 1210.4IL2, IL2RA
15gold sodium thiomalate469.4IL2, IL2RA
16alemtuzumab46 1210.4IL2RA, IL2
17pirfenidone46 6210.4IL2, IL2RA
18levamisole46 1210.4IL2RA, IL2
19as 10146 6210.4IL2RA, IL2
20ranitidine46 30 25 1212.4IL2RA, IL2
21mycophenolic acid46 52 1211.4IL2RA, IL2
22okt3469.3IL2, IL2RA
232-chlorodeoxyadenosine469.3IL2RA, IL2
24con a469.3IL2RA, IL2
25sodium arsenite469.3IL2RA, HSPA4, HSPD1
26malondialdehyde469.3HSPD1, HSPA4, IL2RA
272,5-oligoadenylate469.3IL2, IL2RA
28n acetylcysteine469.2IL2RA, HSPA4, HSPD1
29doxorubicin46 52 1211.2HSPD1, HSPA4, IL2RA
30paraffin469.2IL2RA, HSPA4, HSPD1
31alpha-ketoglutarate469.1HSPA4, HSPD1
32il 10469.1IL2, IL2RA
33creatinine469.1IL2RA, HSPA4, HSPD1
34neomycin469.1IL2, HSPA4, HSPD1
35aspartate469.0IL2RA, HSPA4, HSPD1
36mycophenolate mofetil46 52 1211.0IL2, IL2RA
37pentoxifylline46 1210.0IL2RA, IL2
38adenylate469.0HSPD1, HSPA4, IL2RA
39chloroquine46 3 52 30 1213.0IL2RA, IL2, HSPA4
40herbimycin a46 629.9IL2RA, IL2, HSPA4
415fluorouracil468.9IL2RA, IL2, HSPA4
42rantes468.9HSPD1, IL2, IL2RA
43genistein46 30 62 3 25 1213.8HSPA4, IL2, IL2RA
44cyclosporin a46 30 6210.8IL2RA, IL2, HSPD1
45cisplatin46 52 62 1211.8HSPD1, IL2, IL2RA
46cycloheximide468.7IL2, HSPA4, HSPD1
47h2o2468.7IL2RA, HSPA4, HSPD1
48indomethacin46 30 62 1211.4IL2RA, IL2, HSPA4, HSPD1
49dexamethasone46 52 30 1211.4HSPD1, HSPA4, IL2, IL2RA
50vegf468.4IL2RA, IL2, HSPA4, HSPD1

GO Terms for genes affiliated with Cervicitis

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17Gene Ontology
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Biological processes related to Cervicitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chaperone-mediated protein complex assemblyGO:0511319.5HSPA4, HSPD1
2regulation of T cell homeostatic proliferationGO:0460139.1IL2RA, IL2
3response to unfolded proteinGO:0069869.1HSPA4, HSPD1
4positive regulation of activated T cell proliferationGO:0421049.0IL2RA, IL2
5positive regulation of interferon-gamma productionGO:0327299.0HSPD1, IL2
6negative regulation of inflammatory responseGO:0507289.0IL2RA, IL2

Products for genes affiliated with Cervicitis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Cervicitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet