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MCID: CRV039
MIFTS: 49

Cervicitis

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cervicitis

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MalaCards integrated aliases for Cervicitis:

Name: Cervicitis 12 51 14
Uterine Cervicitis 41 69

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


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Summaries for Cervicitis

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MalaCards based summary : Cervicitis, also known as uterine cervicitis, is related to chronic cervicitis and cervix uteri carcinoma in situ. An important gene associated with Cervicitis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are HTLV-I infection and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spinal cord and testes, and related phenotypes are hematopoietic system and liver/biliary system

Wikipedia : 72 Cervices is inflammation of the uterine cervix. Cervicitis in women has many features in common with... more...

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Related Diseases for Cervicitis

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Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1454)
# Related Disease Score Top Affiliating Genes
1 chronic cervicitis 32.7 CDKN2A SERPIND1 SLC12A4
2 cervix uteri carcinoma in situ 32.4 CDKN2A SERPIND1
3 in situ carcinoma 31.4 CDKN2A SERPIND1
4 trichomoniasis 30.0 CD79A IL2
5 salpingitis 29.8 CD79A HSPD1
6 cervix disease 29.8 CD79A CDKN2A FLNA MRAP MT-TG SERPIND1
7 intermediate uveitis 29.4 IL2 IL2RA
8 acquired immunodeficiency syndrome 29.4 CD79A IL2 IL2RA
9 chronic graft versus host disease 29.3 CD79A IL2RA
10 leprosy 3 29.3 CD79A HSPD1 IL2
11 combined immunodeficiency, x-linked 29.3 CD79A IL2 IL2RA
12 erythema multiforme 29.2 CD79A IL2
13 periodontal disease 29.1 CD79A DEFB4A HSPD1
14 tetanus 29.0 CD79A IL2 IL2RA
15 vaginal disease 29.0 CD79A DEFB4A FLNA
16 acute salpingitis 29.0 CD79A MRAP
17 adult t-cell leukemia 29.0 CDKN2A IL2 IL2RA
18 urethritis 28.8 CD79A DEFB4A HSPD1 MRAP MT-TG
19 reactive arthritis 28.6 CD79A HSPD1
20 cervical cancer 12.4
21 cervical dystonia 12.2
22 cervical rib 12.2
23 cervical incompetence 12.2
24 cervical polyp 12.1
25 cervical adenosarcoma 12.1
26 cervical adenosquamous carcinoma 12.1
27 isolated anterior cervical hypertrichosis 12.1
28 microcephaly with cervical spine fusion anomalies 12.0
29 midline cervical cleft 12.0
30 cervical squamous cell carcinoma 12.0
31 cervical adenocarcinoma 12.0
32 cervical intraepithelial neoplasia 12.0
33 cervical wilms' tumor 12.0
34 cervical carcinosarcoma 11.9
35 cervical alveolar soft part sarcoma 11.9
36 glassy cell variant cervical adenosquamous carcinoma 11.9
37 cervical hypertrichosis peripheral neuropathy 11.9
38 cervical adenitis 11.9
39 acute gonococcal cervicitis 11.9
40 cervical adenoid cystic carcinoma 11.9
41 acute cervicitis 11.9
42 klippel-feil syndrome 11.9
43 cervical clear cell adenocarcinoma 11.9
44 cervical verrucous carcinoma 11.9
45 cervical adenoma malignum 11.9
46 early invasive cervical adenocarcinoma 11.9
47 congenital cervical spinal stenosis 11.9
48 hypertrichosis, anterior cervical 11.9
49 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 11.9
50 microinvasive cervical squamous cell carcinoma 11.9

Graphical network of the top 20 diseases related to Cervicitis:



Diseases related to Cervicitis
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Symptoms & Phenotypes for Cervicitis

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MGI Mouse Phenotypes related to Cervicitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CD79A CDKN2A FLNA IL2 IL2RA SERPIND1
2 liver/biliary system MP:0005370 9.02 CD79A CDKN2A FLNA IL2 SLC12A4
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Drugs & Therapeutics for Cervicitis

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Drugs for Cervicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6 Anti-Bacterial Agents Phase 4,Phase 3
7 Antibiotics, Antitubercular Phase 4
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2
9 Antimalarials Phase 4
10 Antiparasitic Agents Phase 4,Phase 2
11 Antiprotozoal Agents Phase 4,Phase 2
12
Cefixime Approved, Investigational Phase 3 79350-37-1 5362065 54362
13
Metronidazole Approved Phase 2 443-48-1 4173
14
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
3 Empiric Therapy of Mucopurulent Cervicitis (MPC) Terminated NCT01072136 Phase 3 Azithromycin;Cefixime
4 Metronidazole for Pulmonary Tuberculosis (South Korea) Completed NCT00425113 Phase 2 Metronidazole
5 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747 ceftriaxone;Azithromycin
6 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439
7 "Performance of HPV DNA Test in Presence of Co-infection With Common RTIs" Not yet recruiting NCT02830230 Tab cefixime,Tab Azithromycin

Search NIH Clinical Center for Cervicitis

Cochrane evidence based reviews: uterine cervicitis

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Genetic Tests for Cervicitis

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Anatomical Context for Cervicitis

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MalaCards organs/tissues related to Cervicitis:

38
Lymph Node, Spinal Cord, Testes, Cervix, Thyroid, Bone, Endothelial
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Publications for Cervicitis

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Articles related to Cervicitis:

(show top 50) (show all 11509)
# Title Authors Year
1
Characteristic findings of high-grade cervical intraepithelial neoplasia or more on magnifying endoscopy with narrow band imaging. ( 29446041 )
2018
2
Case of heterotopic cervical pregnancy and total placenta accreta after artificial cycle frozen-thawed embryo transfer. ( 29371827 )
2018
3
Efficacy and safety of DoceAqualip in a patient with locally advanced cervical cancer: A case report. ( 29435291 )
2018
4
A case report of cervical neurofibrosarcoma: Clinical presentation, treatment and outcome. ( 29253810 )
2018
5
A case of peritoneal malignant mesothelioma following radiation therapy for cervical cancer. ( 29435293 )
2018
6
Usefulness of the maximum standardized uptake value for the diagnosis and staging of patients with cervical cancer undergoing positron emission tomography/computed tomography. ( 29443749 )
2018
7
Risk factors for non-fusion segment disease after anterior cervical spondylosis surgery: a retrospective study with long-term follow-up of 171 patients. ( 29394936 )
2018
8
Physiological effects of subthalamic nucleus deep brain stimulation surgery in cervical dystonia. ( 29326293 )
2018
9
Radiation-induced leiomyosarcoma of the rectum after cervical cancer treatment. ( 29439826 )
2018
10
Biomechanics of coupled motion in the cervical spine during simulated whiplash in patients with pre-existing cervical or lumbar spinal fusion: A Finite Element Study. ( 29330341 )
2018
11
Distribution of cervical metastasis in tongue cancer: Are occult metastases predictable? A retrospective study of 117 oral tongue carcinomas. ( 29174473 )
2018
12
Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study. ( 29445289 )
2018
13
Early and late pregnancy outcomes in women treated with cold-coagulation versus LLETZ cervical treatment for cervical intraepithelial neoplasia; a retrospective cohort study. ( 29404740 )
2018
14
Depth of Cervical Intraepithelial Neoplasia Grade 3 in Peruvian Women: Implications for Therapeutic Depth of Necrosis. ( 29271853 )
2018
15
Investigation of the effectiveness of therapeutic ultrasound with high-resolution ultrasonographic cross-sectional area measurement of cervical nerve roots in patients with chronic cervical radiculopathy: a prospective, controlled, single-blind study. ( 29318418 )
2018
16
Clinical Validation of a Predictive Model for the Presence of Cervical Lymph Node Metastasis in Papillary Thyroid Cancer. ( 29449283 )
2018
17
Cervical disc arthroplasty with Prestige-LP for the treatment of contiguous 2-level cervical degenerative disc disease: 5-year follow-up results. ( 29369186 )
2018
18
Changes and significance of inflammatory cytokines in a rat model of cervical spondylosis. ( 29387194 )
2018
19
A risk prediction model to allow personalized screening for cervical cancer. ( 29450667 )
2018
20
Sertraline induced cervical dystonia in a patient of Obsessive Compulsive Disorder. ( 29447992 )
2018
21
Upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome. ( 29452216 )
2018
22
Cervical Cancer HeLa Cell Autocrine Apoptosis Induced by Co-immobilized TNF-I+ plus IFN-I^ Biomaterials. ( 29436216 )
2018
23
Prevalence and determinants in cytology testing for cervical cancer screening in Spain (2006-14). ( 29444273 )
2018
24
Don't be short-sighted: cervical incompetence in a pregnant patient with acute appendicitis. ( 29414522 )
2018
25
Congenital cervical kyphosis in an infant with Ehlers-Danlos syndrome. ( 29450629 )
2018
26
Comparison among perfect-CAr, zero-PAr, and plates with a cage in single-level cervical degenerative disc disease. ( 29368613 )
2018
27
Ovarian conservation is associated with better survival in young patients with T1N0M0 cervical adenocarcinoma: a population-based study. ( 29362924 )
2018
28
Postural control and the relation with cervical sensorimotor control in patients with idiopathic adult-onset cervical dystonia. ( 29340715 )
2018
29
Cervical radiculopathy and cervical myelopathy: diagnosis and management in primary care. ( 29284641 )
2018
30
Apparent C8-T1 radiculopathy with hand weakness due to mid-cervical spondylosis. ( 29097135 )
2018
31
Cervical Radiculopathy: Effectiveness of Adding Traction to Physical Therapy. A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( 29315428 )
2018
32
The effectiveness of anterior cervical decompression and fusion for the relief of dizziness in patients with cervical spondylosis: a multicentre prospective cohort study. ( 29305455 )
2018
33
Identification and validation of the role of matrix metalloproteinase-1 in cervical cancer. ( 29436615 )
2018
34
Diagnostic value of human papillomavirus (HPV) 16 and HPV18 viral loads for the detection of high-grade cervical intraepithelial neoplasia (CIN2+) in a cohort of African women living with HIV. ( 29353074 )
2018
35
Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease. ( 29286178 )
2018
36
Comprehensive knowledge on cervical cancer, attitude towards its screening and associated factors among women aged 30-49A years in Finote Selam town, northwest Ethiopia. ( 29444689 )
2018
37
Factors related to subjective satisfaction following microendoscopic foraminotomy for cervical radiculopathy. ( 29361919 )
2018
38
Identifying acute cervicitis in an era of less-frequent routine gynecologic examinations. ( 29369931 )
2018
39
Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (Protocol 1001). ( 29341491 )
2018
40
Insurance status and cancer treatment mediate the association between race/ethnicity and cervical cancer survival. ( 29447263 )
2018
41
Safety and tolerance of cidofovir as a 2% gel for local application in high-grade cervical intraepithelial neoplasia: A phase 1 investigation. ( 29319498 )
2018
42
MicroRNA-492 overexpression involves in cell proliferation, migration, and radiotherapy response of cervical squamous cell carcinomas. ( 28802022 )
2018
43
FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting I^-catenin through mRNA demethylation. ( 29315835 )
2018
44
A 500A U/2A mL dilution of abobotulinumtoxinA vs. placebo: randomized study in cervical dystonia. ( 29343142 )
2018
45
Comparison between cervical disc arthroplasty and conservative treatment for patients with single level cervical radiculopathy at C5/6. ( 29409935 )
2018
46
Unusual case of hemidiaphragmatic paralysis secondary to cervical herpes zoster. ( 29367364 )
2018
47
Anterior cervical arthrodesis for chronic hangman's fracture in a patient with osteopetrosis: a case report. ( 29429065 )
2018
48
Comparison of the clinical effects of zero-profile anchored spacer (ROI-C) and conventional cage-plate construct for the treatment of noncontiguous bilevel of cervical degenerative disc disease (CDDD): A minimum 2-year follow-up. ( 29384883 )
2018
49
Nuclear factor 90 promotes angiogenesis by regulating HIF-1I+/VEGF-A expression through the PI3K/Akt signaling pathway in human cervical cancer. ( 29449553 )
2018
50
Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia. ( 29431861 )
2018
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Variations for Cervicitis

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Expression for Cervicitis

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Search GEO for disease gene expression data for Cervicitis.
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Pathways for Cervicitis

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Pathways related to Cervicitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
HTLV-I infection 36
11.9 CDKN2A IL2 IL2RA
2
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 61
10.86 CD79A IL2 IL2RA
3
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 61
Show member pathways
 10.81 IL2 IL2RA
4
Inflammatory Response Pathway 1
10.67 IL2 IL2RA
5
IL12 signaling mediated by STAT4 1
10.4 IL2 IL2RA
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GO Terms for Cervicitis

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Biological processes related to Cervicitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 9.5 CDKN2A FLNA HSPD1
2 positive regulation of interferon-gamma production GO:0032729 9.49 HSPD1 IL2
3 B cell proliferation GO:0042100 9.48 CD79A HSPD1
4 B cell activation GO:0042113 9.46 CD79A HSPD1
5 positive regulation of activated T cell proliferation GO:0042104 9.43 IL2 IL2RA
6 protein localization to cell surface GO:0034394 9.4 FLNA MRAP
7 apoptotic mitochondrial changes GO:0008637 9.37 CDKN2A HSPD1
8 positive regulation of T cell differentiation GO:0045582 9.26 IL2 IL2RA
9 regulation of regulatory T cell differentiation GO:0045589 9.16 IL2 IL2RA
10 negative regulation of lymphocyte proliferation GO:0050672 8.96 IL2 IL2RA
11 regulation of T cell homeostatic proliferation GO:0046013 8.62 IL2 IL2RA
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Sources for Cervicitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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