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MCID: CRV039
MIFTS: 45

Cervicitis malady

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cervicitis

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Aliases & Descriptions for Cervicitis:

Name: Cervicitis 12 52 14
Uterine Cervicitis 42 69

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Cervicitis

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MalaCards based summary : Cervicitis, also known as uterine cervicitis, is related to tularemia and rheumatoid arthritis. An important gene associated with Cervicitis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and G beta-gamma signalling through PI3Kgamma. The drugs Tetracycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spinal cord and cervix, and related phenotype is hematopoietic system.

Wikipedia : 71 Cervicitis is inflammation of the uterine cervix. Cervicitis in women has many features in common with... more...

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Related Diseases for Cervicitis

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Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1177)
id Related Disease Score Top Affiliating Genes
1 tularemia 29.4 CD79A IL2
2 rheumatoid arthritis 29.3 CD79A HSPD1 IL2 IL2RA
3 histiocytosis 29.3 CD79A DEFB4A HSPD1
4 leiomyosarcoma 29.1 CD79A HSPD1
5 facial hemiatrophy 29.1 CDKN2A IL2
6 parametritis 29.0 IL2 IL2RA
7 fallopian tube carcinoma 29.0 CD79A IL2
8 basilar artery occlusion 28.4 CD79A DEFB4A HSPD1 MT-TG
9 cervical intraepithelial neoplasia 12.2
10 cervical incompetence 12.1
11 cervical dystonia 12.1
12 cervical cancer, somatic 12.1
13 cervical polyp 12.0
14 cervical adenosquamous carcinoma 12.0
15 midline cervical cleft 11.9
16 cervical adenosarcoma 11.9
17 mitral regurgitation, conductive deafness, and fusion of cervical vertebrae and of carpal and tarsal bones 11.9
18 cervical squamous cell carcinoma 11.9
19 cervical adenocarcinoma 11.9
20 cervical wilms' tumor 11.9
21 glassy cell variant cervical adenosquamous carcinoma 11.8
22 cervical alveolar soft part sarcoma 11.8
23 cervical carcinosarcoma 11.8
24 cervical adenitis 11.8
25 chronic cervicitis 11.8
26 klippel-feil syndrome 11.8
27 cervical adenoid cystic carcinoma 11.8
28 acute cervicitis 11.8
29 early invasive cervical adenocarcinoma 11.7
30 cervical adenoma malignum 11.7
31 cervical clear cell adenocarcinoma 11.7
32 cervical verrucous carcinoma 11.7
33 isolated anterior cervical hypertrichosis 11.7
34 microinvasive cervical squamous cell carcinoma 11.7
35 cervical neuroblastoma 11.7
36 cervical adenomyoma 11.7
37 cervical adenofibroma 11.7
38 cervical large cell neuroendocrine carcinoma 11.7
39 familial cervical artery dissection 11.7
40 cervical aortic arch 11.7
41 microcephaly with cervical spine fusion anomalies 11.7
42 central cervical cord syndrome 11.7
43 cervical dermoid cyst 11.7
44 cervical spina bifida cystica 11.7
45 acute gonococcal cervicitis 11.6
46 cervical mullerian papilloma 11.6
47 cervical mucinous adenocarcinoma 11.6
48 cervical keratinizing squamous cell carcinoma 11.6
49 hypertrichosis, anterior cervical 11.6
50 cervical basaloid squamous cell carcinoma 11.6

Graphical network of the top 20 diseases related to Cervicitis:



Diseases related to Cervicitis
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Symptoms & Phenotypes for Cervicitis

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MGI Mouse Phenotypes related to Cervicitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.17 CD79A CDKN2A FLNA GP6 IL2 IL2RA
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Drugs & Therapeutics for Cervicitis

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Drugs for Cervicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
2
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
3
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
4
Lymecycline Approved Phase 4 992-21-2 5280963
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6 Anti-Bacterial Agents Phase 4,Phase 3
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2
8 Antimalarials Phase 4
9 Antibiotics, Antitubercular Phase 4
10 Antiparasitic Agents Phase 4,Phase 2
11 Antiprotozoal Agents Phase 4,Phase 2
12
Cefixime Approved Phase 3 79350-37-1 54362 5362065
13
Metronidazole Approved Phase 2 443-48-1 4173
14
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:


id Name Status NCT ID Phase
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4
2 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4
3 Empiric Therapy of Mucopurulent Cervicitis (MPC) Terminated NCT01072136 Phase 3
4 Metronidazole for Pulmonary Tuberculosis (South Korea) Completed NCT00425113 Phase 2
5 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439
6 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747
7 "Performance of HPV DNA Test in Presence of Co-infection With Common RTIs" Not yet recruiting NCT02830230

Search NIH Clinical Center for Cervicitis

Cochrane evidence based reviews: uterine cervicitis

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Genetic Tests for Cervicitis

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Anatomical Context for Cervicitis

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MalaCards organs/tissues related to Cervicitis:

39
Lymph Node, Spinal Cord, Cervix, Testes, Thyroid, Bone, Endothelial
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Publications for Cervicitis

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Articles related to Cervicitis:

(show top 50) (show all 10890)
id Title Authors Year
1
Chondrosarcoma-like metastasis from a poorly differentiated uterine cervical squamous cell carcinoma. A unique morphology and diagnostic pitfall in cytology. ( 28411397 )
2017
2
Expression of Long Noncoding RNA Urothelial Cancer Associated 1 Promotes Cisplatin Resistance in Cervical Cancer. ( 28414550 )
2017
3
Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients. ( 27323894 )
2017
4
Epigenetic activation of WHSC1 functions as an oncogene and is associated with poor prognosis in cervical cancer. ( 28260054 )
2017
5
Aberrant TIMELESS expression is associated with poor clinical survival and lymph node metastasis in early-stage cervical carcinoma. ( 27909716 )
2017
6
Quadriplegia caused by an epidural abscess occurring at the same level of cervical destructive spondyloarthropathy: a case report. ( 28068970 )
2017
7
MicroRNA-543 acts as a prognostic marker and promotes the cell proliferation in cervical cancer by BRCA1-interacting protein 1. ( 28231728 )
2017
8
Frequency of Chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16/Ki-67 dual-staining. ( 28074107 )
2017
9
Cervical artery tortuosity is associated with intracranial aneurysm. ( 28073311 )
2017
10
Artificial cervical disc replacement with the Prestige-LP prosthesis for the treatment of non-contiguous 2-level cervical degenerative disc disease: A minimum 24-month follow-up. ( 27902945 )
2017
11
The occurrence of lateral shift in cervical dystonia. ( 28054172 )
2017
12
miR-25-3p reverses epithelial-mesenchymal transition via targeting Sema4C in cisplatin-resistance cervical cancer cells. ( 27743413 )
2017
13
Expression of Ezrin and Estrogen Receptors During Cervical Carcinogenesis. ( 27688241 )
2017
14
Immediate and lasting effects of a thoracic spine manipulation in a patient with signs of cervical radiculopathy and upper extremity hyperalgesia: A case report. ( 27911127 )
2017
15
Roles of immune inhibitory molecule B7-H4 in cervical cancer. ( 28260085 )
2017
16
Study protocol for a randomised controlled multicentre study: the Foraminotomy ACDF Cost-Effectiveness Trial (FACET) in patients with cervical radiculopathy. ( 28057652 )
2017
17
Prognostic value of cervical nodal tumor volume in nasopharyngeal carcinoma: Analysis of 1230 patients with positive cervical nodal metastasis. ( 28489930 )
2017
18
Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients. ( 28341818 )
2017
19
Type-Dependent Association between Risk of Cervical Intraepithelial Neoplasia and Viral Load of Oncogenic Human Papillomavirus Types Other than Types 16 and 18. ( 28052328 )
2017
20
Ultrasonography has a diagnostic value in the assessment of cervical radiculopathy: A prospective pilot study. ( 28050690 )
2017
21
Vaginal Hysterectomy for Treatment of Cervical Ectopic Pregnancy. ( 27926641 )
2017
22
Reply: Contributions of visual and motor signals in cervical dystonia. ( 27993889 )
2017
23
MicoRNA-425-5p is a potential prognostic biomarker for cervical cancer. ( 27166306 )
2017
24
MicroRNA-362 is downregulated in cervical cancer and inhibits cell proliferation, migration and invasion by directly targeting SIX1. ( 27878258 )
2017
25
Stomach Cancer Following Hodgkin Lymphoma, Testicular Cancer and Cervical Cancer: A Pooled Analysis of Three International Studies with a Focus on Radiation Effects. ( 28118119 )
2017
26
Cervical Osteochondroma Causing Myelopathy in Adults: Management Considerations and Literature Review. ( 27777159 )
2017
27
NHERF1 Enhances Cisplatin Sensitivity in Human Cervical Cancer Cells. ( 28085111 )
2017
28
Corpora amylacea and molluscum contagiosum on a cervical pap smear. ( 27863182 )
2017
29
High-mobility group box 1 is overexpressed in cervical carcinoma and promotes cell invasion and migration inA vitro. ( 28000879 )
2017
30
A rare association of dysphagia and cervical compressive myelopathy in diffuse idiopathic skeletal hyperostosis. ( 28084279 )
2017
31
Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. ( 28526810 )
2017
32
Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions. ( 28414756 )
2017
33
The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl terminus-1 function and is a risk factor for uterine cervical cancer. ( 27996172 )
2017
34
Modulation of the muscle activity during sleep in cervical dystonia. ( 28525628 )
2017
35
Intradural Dirofilariasis in a Dog with Chronic Cervical Pain. ( 27841685 )
2017
36
High VEGFR1/2 expression levels are predictors of poor survival in patients with cervical cancer. ( 28072723 )
2017
37
miR424-5p functions as an anti-oncogene in cervical cancer cell growth by targeting KDM5B via the Notch signaling pathway. ( 28082020 )
2017
38
Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy. ( 27995057 )
2017
39
Cervical spine involvement risk factors in rheumatoid arthritis: a meta-analysis. ( 28524646 )
2017
40
Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells. ( 27959427 )
2017
41
Sulfiredoxin may promote metastasis and invasion of cervical squamous cell carcinoma by epithelial-mesenchymal transition. ( 28351308 )
2017
42
Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis. ( 28261610 )
2017
43
Contributions of visual and motor signals in cervical dystonia. ( 27993890 )
2017
44
Neck and Occipital Pain Caused by Deep Cervical Intramuscular Lipoma: A Surgical Case. ( 28502967 )
2017
45
Collateral Assessment by CT Angiography as a Predictor of Outcome in Symptomatic Cervical Internal Carotid Artery Occlusion. ( 27765736 )
2017
46
Erratum to: Cytokeratin7 and cytokeratin19 expression in high grade cervical intraepithelial neoplasm and squamous cell carcinoma and their possible association in cervical carcinogenesis. ( 28532486 )
2017
47
HR-HPV E6/E7 mRNA In Situ Hybridization: Validation Against PCR, DNA In Situ Hybridization, and p16 Immunohistochemistry in 102 Samples of Cervical, Vulvar, Anal, and Head and Neck Neoplasia. ( 28403015 )
2017
48
Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis. ( 28144684 )
2017
49
Effects of Long-Term Vitamin D Supplementation on Regression and Metabolic Status of Cervical Intraepithelial Neoplasia: a Randomized, Double-Blind, Placebo-Controlled Trial. ( 28050798 )
2017
50
Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway. ( 28011380 )
2017
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Variations for Cervicitis

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Expression for Cervicitis

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Search GEO for disease gene expression data for Cervicitis.
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Pathways for Cervicitis

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Pathways related to Cervicitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 62
Show member pathways
 12.8 FLNA GP6 IL2 IL2RA SERPIND1
2
G beta-gamma signalling through PI3Kgamma 62
Show member pathways
 11.32 GP6 IL2 IL2RA
3
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 61
Show member pathways
 10.97 IL2 IL2RA
4
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 61
10.87 CD79A IL2 IL2RA
5
Inflammatory Response Pathway 1
10.78 IL2 IL2RA
6
IL12 signaling mediated by STAT4 1
10.6 IL2 IL2RA
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GO Terms for Cervicitis

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Biological processes related to Cervicitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of interferon-gamma production GO:0032729 9.43 HSPD1 IL2
2 B cell proliferation GO:0042100 9.4 CD79A HSPD1
3 B cell activation GO:0042113 9.37 CD79A HSPD1
4 positive regulation of activated T cell proliferation GO:0042104 9.32 IL2 IL2RA
5 apoptotic mitochondrial changes GO:0008637 9.26 CDKN2A HSPD1
6 positive regulation of T cell differentiation GO:0045582 9.16 IL2 IL2RA
7 negative regulation of lymphocyte proliferation GO:0050672 8.96 IL2 IL2RA
8 regulation of T cell homeostatic proliferation GO:0046013 8.62 IL2 IL2RA
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Sources for Cervicitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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