Aliases & Classifications for Cervix Disease

MalaCards integrated aliases for Cervix Disease:

Name: Cervix Disease 12 14
Uterine Cervical Diseases 41
Cervix Disorders 40
Cervix Diseases 69


External Ids:

Disease Ontology 12 DOID:2253
MeSH 41 D002577
NCIt 46 C40241
UMLS 69 C0007867

Summaries for Cervix Disease

MedlinePlus : 40 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. The cervix has a small opening that expands during childbirth. It also allows menstrual blood to leave a woman's body. Your health care provider may perform a Pap test during your health checkup to look for changes to the cells of the cervix, including cervical cancer. Other problems with the cervix include: Cervicitis - inflammation of the cervix. This is usually from an infection. Cervical incompetence - This can happen during pregnancy. The opening of the cervix widens long before the baby is due. Cervical polyps and cysts - abnormal growths on the cervix

MalaCards based summary : Cervix Disease, also known as uterine cervical diseases, is related to cervicitis and cervical polyp, and has symptoms including pelvic pain An important gene associated with Cervix Disease is MT-TG (Mitochondrially Encoded TRNA Glycine), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and lymph node, and related phenotypes are cardiovascular system and mortality/aging

Wikipedia : 72 The cervix or cervix uteri (Latin: neck of the uterus) is the lower part of the uterus in the human... more...

Related Diseases for Cervix Disease

Diseases related to Cervix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 cervicitis 28.3 CD79A CDKN2A FLNA MRAP MT-TG SERPIND1
2 cervical polyp 10.8
3 cervical incompetence 10.8
4 mite infestation 10.4 CD79A FLNA
5 punctate palmoplantar keratoderma 10.4 FLNA MRAP
6 diffuse pulmonary fibrosis 10.3 MRAP SERPINH1
7 anterior scleritis 10.3 CD79A MRAP
8 chronic orbital inflammation 10.3 CD79A MRAP
9 balanoposthitis 10.3 CDKN2A GP6
10 anogenital venereal wart 10.3 CDKN2A GP6
11 oropharynx cancer 10.3 CDKN2A GP6
12 selective igg deficiency disease 10.3 CD40LG CD79A
13 c1q nephropathy 10.3 CD40LG CD79A
14 cicatricial pemphigoid 10.3 CD79A SERPINH1
15 meningovascular neurosyphilis 10.3 CD40LG CD79A
16 alpha chain disease 10.3 CD40LG CD79A
17 pre-malignant neoplasm 10.3 CDKN2A SERPIND1
18 brill-zinsser disease 10.3 CD40LG CD79A
19 exudative glomerulonephritis 10.3 CD40LG CD79A
20 cork-handlers' disease 10.3 CD40LG CD79A
21 salpingo-oophoritis 10.3 CD40LG CD79A
22 early yaws 10.3 CD40LG CD79A
23 ventilation pneumonitis 10.3 CD40LG CD79A
24 chronic interstitial cystitis 10.3 CD40LG CD79A
25 axillary adenitis 10.3 CD40LG CD79A
26 cryofibrinogenemia 10.3 CD40LG CD79A
27 trichostrongyloidiasis 10.3 CD40LG CD79A
28 subacute bacterial endocarditis 10.3 CD40LG CD79A
29 heterophyiasis 10.3 CD40LG CD79A
30 immunoglobulin g deficiency 10.3 CD40LG CD79A
31 myasthenic syndrome, congenital, 10 10.3 CD40LG MT-TG
32 orbital granuloma 10.3 CD40LG CD79A
33 transient hypogammaglobulinemia of infancy 10.3 CD40LG CD79A
34 hyperglobulinemic purpura 10.3 CD40LG CD79A
35 gastroduodenitis 10.3 CD40LG CD79A
36 bacterial conjunctivitis 10.3 CD40LG CD79A
37 heavy chain disease 10.3 CD40LG CD79A
38 ophthalmia neonatorum 10.3 CD40LG CD79A
39 immunoglobulin a deficiency 1 10.3 CD40LG CD79A
40 parotid disease 10.3 CD40LG CD79A
41 cerebral arteritis 10.3 CD40LG CD79A
42 selective immunoglobulin deficiency disease 10.3 CD40LG CD79A
43 geniculate herpes zoster 10.3 CD40LG CD79A
44 erythema elevatum diutinum 10.3 CD40LG CD79A
45 sporotrichosis 10.2 CD40LG CD79A
46 fallopian tube disease 10.2 CD40LG CD79A
47 hyperimmunoglobulin syndrome 10.2 CD40LG CD79A
48 congenital syphilis 10.2 CD40LG CD79A
49 polyclonal hypergammaglobulinemia 10.2 CD40LG CD79A
50 monoclonal paraproteinemia 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Cervix Disease:

Diseases related to Cervix Disease

Symptoms & Phenotypes for Cervix Disease

UMLS symptoms related to Cervix Disease:

pelvic pain

MGI Mouse Phenotypes related to Cervix Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CD40LG CDKN2A FLNA SERPIND1 SERPINH1 SLC12A4
2 mortality/aging MP:0010768 9.28 CD40LG CDKN2A FLNA GP6 MID1 SERPIND1

Drugs & Therapeutics for Cervix Disease

Drugs for Cervix Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 421)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
Cisplatin Approved Phase 4,Phase 2,Phase 3,Phase 1 15663-27-1 2767 441203 84093
Bupropion Approved Phase 4,Phase 2 34911-55-2, 34841-39-9 444
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
Nicotine Approved Phase 4 54-11-5 89594 942
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Iron Approved Phase 4,Phase 1,Phase 2 7439-89-6 23925
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
Chloroprocaine Approved Phase 4 133-16-4 8612
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
Vitamin C Approved, Nutraceutical Phase 4,Phase 2 50-81-7 54670067 5785
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
18 Antimalarials Phase 4,Phase 1
19 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
20 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
21 Liver Extracts Phase 4,Phase 2,Phase 1
22 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
24 Psychotropic Drugs Phase 4,Phase 3,Phase 2
25 Epoetin alfa Phase 4,Phase 3 113427-24-0
26 Hematinics Phase 4,Phase 3,Phase 2,Phase 1
27 Anesthetics Phase 4,Phase 3,Phase 2,Early Phase 1
28 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Early Phase 1
29 Fluorodeoxyglucose F18 Phase 4,Phase 3,Phase 2,Phase 1
30 Antidepressive Agents Phase 4,Phase 2
31 Antidepressive Agents, Second-Generation Phase 4,Phase 2
32 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 2
33 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
34 Dopamine Agents Phase 4,Phase 2
35 Dopamine Uptake Inhibitors Phase 4,Phase 2
36 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
37 Autonomic Agents Phase 4,Phase 3,Phase 2
38 Central Nervous System Stimulants Phase 4,Phase 2
39 Cholinergic Agents Phase 4
40 Nicotinic Agonists Phase 4
41 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
42 Anesthetics, Local Phase 4,Phase 3,Phase 2
43 Adjuvants, Anesthesia Phase 4
44 Analgesics Phase 4,Phase 2,Phase 1,Early Phase 1
45 Analgesics, Opioid Phase 4
46 Anesthetics, General Phase 4
47 Anesthetics, Intravenous Phase 4
48 Narcotics Phase 4,Early Phase 1
49 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
50 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1010)

# Name Status NCT ID Phase Drugs
1 Can Alternative Treatment Have an Impact on Cervical Dysplasia? Unknown status NCT00842738 Phase 4
2 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
3 Does the HPV Vaccine Cause the Same Response in Adolescent Kidney and Liver Transplant Patients as in Healthy Controls? Unknown status NCT01101750 Phase 4
4 Primary and Secondary Prevention of Human Papillomavirus (HPV) Disease in China Unknown status NCT01021904 Phase 4
5 The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies. Completed NCT03384511 Phase 4 Apatinib
6 Effect of HPV Vaccination on Women Aged 25 Years Completed NCT02296255 Phase 4
7 Alternate Dosing Schedules Study for HPV Vaccine (ADS) Completed NCT02280642 Phase 4
8 Comparing the Rate of Insufficient Cells for Diagnosis Between Surepath® and Conventional Smear in Women After Radiation Therapy for Cervical Cancer Completed NCT01988376 Phase 4
9 V501 Safety and Efficacy Study in Japanese Women Aged 16 to 26 Years (V501-110) Completed NCT01544478 Phase 4
10 Delivery, Uptake and Acceptability of HPV Vaccination in Tanzanian Girls Completed NCT01173900 Phase 4
11 Management of Cervical Intraepithelial Neoplasia Grade 2 Completed NCT00733109 Phase 4
12 Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease Completed NCT01034358 Phase 4
13 Alternate Dosing Schedules Study for HPV Vaccine Completed NCT00862810 Phase 4
14 Patient Navigation in the Safety Net:CONNECTeDD Completed NCT00613275 Phase 4
15 Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking Completed NCT00666978 Phase 4 bupropion hydrochloride
16 Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking Completed NCT00365508 Phase 4 nicotine lozenge;nicotine patch
17 Epoetin Beta in Treating Anemia in Patients With Cervical Cancer Completed NCT00046969 Phase 4 cisplatin
18 A Study of Korean Society of Spine Surgery on the Outcomes of Anterior Cervical Discectomy and Fusion Recruiting NCT01911013 Phase 4
19 Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Recruiting NCT03305575 Phase 4 Chloroprocaine;Bupivacaine
20 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Recruiting NCT02862912 Phase 4 Chloroprocaine;Bupivacaine;Fentanyl;Saline
21 Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines Recruiting NCT03180034 Phase 4
22 HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions Recruiting NCT03051516 Phase 4
23 Comparing Health Services Interventions for the Prevention of HPV-related Cancer Recruiting NCT02837926 Phase 4
24 Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates. Recruiting NCT01953107 Phase 4
25 The Efficacy of Tachosil® for Prevention of Hemorrhage After Loop Electrosurgical Excisional Procedure (LEEP) Active, not recruiting NCT02629510 Phase 4 Tachosil
26 CervIcal Cancer Screening Trial by Randomization of HPV Testing Intervention for Upcoming Screening (CITRUS Study) Active, not recruiting NCT01895517 Phase 4
27 Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India Active, not recruiting NCT00923702 Phase 4
28 Effectiveness of Cervical Screening in HPV Vaccinated Women Enrolling by invitation NCT02149030 Phase 4
29 Pilot Study to Assess the Potential Clinical Utility of 18F Fluciclovine PET for Cervical and Endometrial Cancer. Not yet recruiting NCT03423082 Phase 4 18F fluciclovine
30 Evaluation of Fluciclovine Uptake in Patients With Cervical, Ovarian Epithelial or Endometrial Cancers. Not yet recruiting NCT03349463 Phase 4 Fluciclovine F18
31 To Evaluate the Efficacy and Safety of PEG-rhG-CSF(Jinyouli®) in Reducing Neutropenia in Patients With Cervical Cancer Not yet recruiting NCT03206684 Phase 4 PEG-rhG-CSF;rhG-CSF
32 Dissemination of Cervical Cancer Screening to Primary Care Physicians in Underserved Communities Terminated NCT00629993 Phase 4
33 Study With Intensity Modulated Radiation Therapy With Cisplatin to Treat Stage I-IVA Cervical Cancer Unknown status NCT01554397 Phase 2, Phase 3 Cisplatin
34 Study on Paclitaxel Plus Topotecan in Comparison With Topotecan Plus Cisplatin in Recurrent or Persistent Cervical Carcinoma Unknown status NCT01405235 Phase 3 Paclitaxel;Cisplatin/Paclitaxel
35 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
36 Cisplatin Based Chemoradiation v.s Radiotherapy for Cervical Cancer and With Clinically Defined Good Prognosis Unknown status NCT00846508 Phase 3 Cisplatin
37 Radiotherapy With Single-Agent Cisplatin or Combination Chemotherapy in Defined Poor-Prognostic Cervical Cancer Unknown status NCT00842660 Phase 3 Gemzar (gemcitabine)
38 The Assessment of Preoperative Psychological Intervention on Stress in Women With Gynecological Malignancies Unknown status NCT00726635 Phase 3
39 Randomized Trial Between Weekly and 5 Day 3 Weekly Cisplatin for Cervical Cancer Unknown status NCT00548821 Phase 3 Cisplatin
40 Hydralazine Valproate for Cervical Cancer Unknown status NCT00532818 Phase 3 Hydralazine and magnesium valproate;Placebo
41 Partnership for Healthy Seniors Unknown status NCT00379743 Phase 3
42 Impact of Erythropoietin Administration During Definitive Cervix Cancer Radiotherapy on Treatment Outcome Unknown status NCT00348738 Phase 3 Erythropoietin
43 Usefulness of FDG-PET for Advanced Cervical Cancer Unknown status NCT00146458 Phase 3
44 Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients Unknown status NCT00122746 Phase 3
45 The IMAP Study Improving Management of Mildly Abnormal Pap Smears Unknown status NCT00119509 Phase 3
46 Immunogenicity Bridge Between an Investigational Monovalent Vaccine and the Equivalent Component of Gardasil (V501) a Quadrivalent Vaccine (V501-012)(COMPLETED) Completed NCT00092482 Phase 3
47 Clinical Evaluation of the APTIMA® HPV Assay Using the TIGRIS® System Completed NCT00973362 Phase 3
48 Noncarious Cervical Lesion Treatment Outcomes Completed NCT00867997 Phase 3
49 A Phase III Randomized Trial of Topical Vaginal Fluorouracil (5-Fluorouracil, 5-FU) Maintenance Therapy Versus Observation After Standard Treatment for High-Grade Cervical Dysplasia in HIV-Infected Women Completed NCT00000758 Phase 3 Fluorouracil
50 Safety and Effectiveness of Giving Isotretinoin to HIV-Infected Women to Treat Cervical Tumors Completed NCT00001073 Phase 3 Isotretinoin

Search NIH Clinical Center for Cervix Disease

Cochrane evidence based reviews: uterine cervical diseases

Genetic Tests for Cervix Disease

Anatomical Context for Cervix Disease

MalaCards organs/tissues related to Cervix Disease:

Cervix, Testes, Lymph Node, Uterus, Breast, T Cells, Prostate

Publications for Cervix Disease

Articles related to Cervix Disease:

# Title Authors Year
Association of KIR genes and HLA-C alleles with HPV-related uterine cervical disease in Korean women. ( 23398510 )

Variations for Cervix Disease

Expression for Cervix Disease

Search GEO for disease gene expression data for Cervix Disease.

Pathways for Cervix Disease

Pathways related to Cervix Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Cervix Disease

Biological processes related to Cervix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 9.16 CD40LG CD79A
2 protein localization to cell surface GO:0034394 8.96 FLNA MRAP
3 platelet activation GO:0030168 8.8 CD40LG FLNA GP6

Sources for Cervix Disease

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
51 Novoseek
54 OMIM via Orphanet
58 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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